SUGEN INC
S-8, 1999-08-23
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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        As filed with the Securities and Exchange Commission on August 23, 1999

================================================================================

                                            Registration No. 333 - _____________

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                        ---------------------------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                        ---------------------------------


                                   SUGEN, Inc.
                        ---------------------------------
             (Exact name of registrant as specified in its charter)


        DELAWARE                                        13-3629196
- ------------------------                    ------------------------------------
(State of Incorporation)                    (I.R.S. Employer Identification No.)


                              230 East Grand Avenue
                      South San Francisco, California 94080
                                 (650) 553-8300
          -------------------------------------------------------------
          (Address and telephone number of principal executive offices)


                             1992 STOCK OPTION PLAN
                        1994 EMPLOYEE STOCK PURCHASE PLAN
                        ---------------------------------
                            (Full title of the plans)

                               Stephen Evans-Freke
                              Chairman of the Board
                                   SUGEN, Inc.
                              230 East Grand Avenue
                      South San Francisco, California 94080
                                 (650) 553-8300
- --------------------------------------------------------------------------------
           (Name, address, including zip code, and telephone number,
                   including area code, of agent for service)

                        ---------------------------------

                                   Copies to:
                          Suzanne Sawochka Hooper, Esq.
                               Cooley Godward LLP
                              Five Palo Alto Square
                               Palo Alto, CA 94306
                                 (650) 843-5000

                        ---------------------------------

<TABLE>
<CAPTION>
                                                  CALCULATION OF REGISTRATION FEE
====================================================================================================================================
       Title of Securities             Amount to be          Proposed Maximum          Proposed Maximum             Amount of
         to be Registered               Registered       Offering Price Per Share  Aggregate Offering Price     Registration Fee
                                                                    (1)                       (1)
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                                       <C>                <C>                          <C>                       <C>
Stock Options and Common Stock            950,000            $13.00 - $30.1875            $26,567,709               $7385.82
(par value $.01)
====================================================================================================================================
<FN>
(1)      Estimated  solely for the purpose of  calculating  the amount of the  registration  fee pursuant to Rule 457(c) and (h)(1)
         under the Securities Act of 1933, as amended (the " Securities Act"). The offering price per share and aggregate  offering
         price for the  unissued  stock  options  and  Common  Stock  are  based  upon the  average  of the high and low  prices of
         Registrant's  Common Stock as reported on the Nasdaq  National  Market System on August 19, 1999.  The offering  price per
         share and aggregate  offering price for the outstanding  stock options are based upon the exercise prices of such options.
         The following chart illustrates the calculation of the registration fee:
</FN>
====================================================================================================================================
</TABLE>

<PAGE>

<TABLE>
<CAPTION>
====================================================================================================================================

                         Title of Shares                             Number of Shares      Offering Price Per    Aggregate Offering
                                                                                                  Share                 Price
- ------------------------------------------------------------------------------------------------------------------------------------
<S>                                                                       <C>                <C>                     <C>
Shares issuable pursuant to outstanding stock options pursuant            190,148            $13.00 - $29.50         $ 3,629,677
to the 1992 Stock Option Plan

- ------------------------------------------------------------------------------------------------------------------------------------

Shares issuable pursuant to unissued stock options pursuant to            559,852               $30.1875             $16,900,532
the 1992 Stock Option Plan

- ------------------------------------------------------------------------------------------------------------------------------------

Shares issuable pursuant to unissued stock options pursuant to            200,000               $30.1875             $ 6,037,500
the 1994 Employee Stock Purchase Plan

- ------------------------------------------------------------------------------------------------------------------------------------

Proposed Maximum Aggregate Offering Price                                                                            $26,567,709

====================================================================================================================================


- ------------------------------------------------------------------------------------------------------------------------------------

         Approximate date of commencement of proposed sale to the public: As soon as practicable after this Registration  Statement
becomes effective.
</TABLE>



                                                                 2

<PAGE>

                                EXPLANATORY NOTE

This  Registration  Statement  on Form S-8 is being  filed  for the  purpose  of
registering an additional 750,000 shares of the Registrant's  Common Stock to be
issued  pursuant to the  Registrant's  1992 Stock Option  Plan,  as amended (the
"Option Plan") and an additional 200,000 shares of the Registrant's Common Stock
to be issued pursuant to the Registrant's  1994 Employee Stock Purchase Plan, as
amended  (the  "Purchase  Plan").  The  Registration   Statements  on  Form  S-8
previously  filed with the Commission  relating to the Option Plan, the Purchase
Plan and the 1994 Non-Employee Directors' Plan (File No. 33-89270 filed with the
Commission on February 8, 1995 and amended on August 1, 1995; File No. 333-09326
filed with the Commission on August 1, 1996,  File No.  333-30385 filed with the
Commission  on June 30, 1997 and File No.:  333-64439 on September 28, 1998) are
incorporated by reference herein.


                                    EXHIBITS

Exhibit
Number

5.1       Opinion of Cooley Godward LLP.

23.1      Consent of Ernst & Young LLP, Independent Auditors.

23.2      Consent of Cooley Godward LLP.  Reference is made to Exhibit 5.1.

24.1      Power of Attorney.  Reference is made to the signature pages.

99.1      1992 Stock Option Plan, as amended as of February 22, 1999.

99.2      1994 Employee Stock Purchase Plan, as amended as of February 22, 1999.


                                        3

<PAGE>

                                   SIGNATURES

Pursuant to the  requirements  of the  Securities  Act of 1933, as amended,  the
Registrant certifies that it has reasonable grounds to believe that it meets all
of the requirements for filing on Form S-8 and has duly caused this Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized,  in the City of South San Francisco,  County of San Mateo,  State of
California, on August 16, 1999.

                                         SUGEN, Inc.



                                         By  /s/  Stephen Evans-Freke
                                            -----------------------------------
                                                  Stephen Evans-Freke
                                                  Chief Executive Officer and
                                                  Chairman of the Board



                                POWER OF ATTORNEY


KNOW ALL PERSONS BY THESE  PRESENTS,  that each person whose  signature  appears
below  constitutes and appoints Stephen  Evans-Freke and James L. Knighton,  and
each or any one of them, his true and lawful  attorney-in-fact  and agent,  with
full power of substitution  and  resubstitution,  for him and in his name, place
and stead, in any and all capacities,  to sign any and all amendments (including
post-effective amendments) to this Registration Statement, and to file the same,
with all exhibits thereto, and other documents in connection therewith, with the
Securities and Exchange  Commission,  granting unto said  attorneys-in-fact  and
agents,  and each of them,  full power and  authority to do and perform each and
every act and thing requisite and necessary to be done in connection  therewith,
as fully to all intents and  purposes as he might or could do in person,  hereby
ratifying and confirming all that said  attorneys-in-fact  and agents, or any of
them, or their or his substitutes or substitute,  may lawfully do or cause to be
done by virtue hereof.
<TABLE>
Pursuant to the  requirements of the Securities Act of 1933,  this  Registration
Statement has been signed by the following  persons in the capacities and on the
dates indicated.
<CAPTION>

Signature                             Title                             Date
<S>                                   <C>                               <C>


/s/  Stephen Evans-Freke              Chief Executive Officer and       August 16, 1999
- -------------------------------       Chairman of the Board
(Stephen Evans-Freke)                 (Principal Executive Officer)


/s/ James L. Knighton                 Senior Vice President and         August 16, 1999
- -------------------------------       Chief Financial Officer
(James L. Knighton)                   (Principal Financial and
                                      Accounting Officer)


                                        4

<PAGE>

/s/ Jeremy L. Curnock Cook            Director                          August 16, 1999
- -------------------------------
(Jeremy L. Curnock Cook)



/s/ Samuel Hamad                      Director                          August 16, 1999
- -------------------------------
(Samuel Hamad)



/s/ Gerald Moller                     Director                          August 16, 1999
- -------------------------------
(Gerald Moller)



 /s/ Donald E. Nickelson              Director                          August 16, 1999
- -------------------------------
(Donald E. Nickelson)



/s/ Richard D. Spizzirri              Director                          August 16, 1999
- -------------------------------
(Richard D. Spizzirri)



/s/ Axel Ullrich                      Director                          August 16, 1999
- -------------------------------
(Axel Ullrich)

</TABLE>


                                        5
<PAGE>

<TABLE>
                                  EXHIBIT INDEX


<CAPTION>
Exhibit                                                                             Sequential
Number             Description                                                      Page Number

<S>       <C>                                                                                <C>
5.1       Opinion of Cooley Godward LLP.                                                      7

23.1      Consent of Ernst & Young LLP, Independent Auditors.                                 8

23.2      Consent of Cooley LLP.  Reference is made to Exhibit 5.1.                           7

24.1      Power of Attorney.  Reference is made to the signature pages.                       3

99.1      1992 Stock Option Plan, as amended as of February 22, 1999.                         9

99.2      1994 Employee Stock Purchase Plan, as amended as of February 22, 1999.             19

</TABLE>
                                        6




                                                                     Exhibit 5.1




August 16, 1999


SUGEN, Inc.
230 East Grand Avenue
South San Francisco, CA 94080

Ladies and Gentlemen:

You have  requested  our opinion with respect to certain  matters in  connection
with the filing by SUGEN,  Inc. (the "Company"),  a Delaware  corporation,  of a
Registration  Statement  on Form S-8  (the  "Registration  Statement")  with the
Securities  and  Exchange  Commission  covering  the offering of an aggregate of
950,000 shares (the "Shares") of the Company's  common stock, par value $.01 per
share (the "Common  Stock"),  which  includes (i) up to 750,000 shares of Common
Stock  pursuant to the Company's 1992 Stock Option Plan, as amended (the "Option
Plan") and (ii) up to 200,000  shares of Common Stock  pursuant to the Company's
Employee Stock Purchase Plan, as amended (the "Purchase Plan").

In connection with this opinion, we have examined the Registration Statement and
related Prospectus,  your Restated Certificate of Incorporation and By-laws, and
such other documents, records, certificates,  memoranda and other instruments as
we deem necessary as a basis for this opinion.  We have assumed the  genuineness
and authenticity of all documents  submitted to us as originals,  the conformity
to originals of all  documents  submitted to us as copies  thereof,  and the due
execution and delivery of all  documents  where due execution and delivery are a
prerequisite to the effectiveness thereof.

On the basis of the foregoing,  and in reliance  thereon,  we are of the opinion
that the Shares,  when sold and issued in accordance  with the Option Plan,  the
Purchase  Plan,  the  Registration  Statement  and related  Prospectus,  will be
validly  issued,  fully  paid,  and  nonassessable  (except as to shares  issued
pursuant to certain deferred payment arrangements,  which will be fully paid and
nonassessable when such deferred payments are made in full).

We  consent to the  filing of this  opinion  as an  exhibit to the  Registration
Statement.

Very truly yours,

COOLEY GODWARD LLP



By:      /s/ Suzanne Sawochka Hooper
         ---------------------------
         Suzanne Sawochka Hooper



                                        7




                                                                    Exhibit 23.1


               Consent of Ernst & Young LLP, Independent Auditors


We consent to the incorporation by reference in the Registration Statement (Form
S-8) of  SUGEN,  Inc.  pertaining  to the 1992  Stock  Option  Plan and the 1994
Employee Stock  Purchase Plan of our report dated  February 5, 1999,  except for
Note 13, as to which the date is March 24, 1999,  with respect to the  financial
statements of SUGEN, Inc. included in its Annual Report (Form 10-K), as amended,
for the year ended  December 31, 1998,  filed with the  Securities  and Exchange
Commission.



                                                               ERNST & YOUNG LLP

Palo Alto, California
August 19, 1999


                                        8




                                                                    Exhibit 99.1

                                   SUGEN, INC.

                             1992 STOCK OPTION PLAN

                            Adopted February 28, 1992
                       Termination Date: February 27, 2002


1.       PURPOSES.

         (a) The  purpose  of the Plan is to  provide a means by which  selected
Employees and Directors of and  Consultants to the Company,  and its Affiliates,
may be given an opportunity to purchase stock of the Company.

         (b) The Company,  by means of the Plan, seeks to retain the services of
persons who are now Employees or Directors of or Consultants to the Company,  to
secure and retain the services of new Employees,  Directors and Consultants, and
to provide  incentives for such persons to exert maximum efforts for the success
of the Company.

         (c) The Company  intends that the Options  issued under the Plan shall,
in the  discretion  of the Board or any  Committee to which  responsibility  for
administration  of the Plan has been delegated  pursuant to subsection  3(c), be
either Incentive Stock Options or Nonstatutory Stock Options.  All Options shall
be separately  designated  Incentive Stock Options or Nonstatutory Stock Options
at the time of grant,  and in such form as issued  pursuant  to Section 6, and a
separate  certificate  or  certificates  will be issued for shares  purchased on
exercise of each type of Option.

2.       DEFINITIONS.

         (a) "Affiliate" means any parent corporation or subsidiary corporation,
whether now or hereafter existing, as those terms are defined in Sections 424(e)
and (f) respectively, of the Code.

         (b) "Board" means the Board of Directors of the Company.

         (c) "Code" means the Internal Revenue Code of 1986, as amended.

         (d) "Committee" means a Committee  appointed by the Board in accordance
with subsection 3(c) of the Plan.

         (e) "Company" means SUGEN, Inc., a Delaware corporation.

         (f) "Consultant" means any person, including an advisor, engaged by the
Company or an Affiliate  to render  consulting  or advisory  services and who is
compensated  for such services,  provided that the term  "Consultant"  shall not
include  Directors who are paid only a director's  fee by the Company or who are
not compensated by the Company for their services as Directors.

         (g) "Continuous Service" (formerly,  "Continuous Status as an Employee,
Director or  Consultant")  means the employment or relationship as a Director or
Consultant is not interrupted or terminated by the Company or any Affiliate. The
Optionee's  Continuous  Service  shall not be deemed to have  terminated  merely
because of a change in the capacity in which the Optionee renders service to the
Company or an Affiliate as an  Employee,  Consultant  or Director or a change in
the entity for which the Optionee  renders such service,  provided that there is
no  interruption  or  termination  of the  Optionee's

<PAGE>

Continuous  Service.  For  example,  a change in status  from an Employee of the
Company to a  Consultant  of an  Affiliate or a Director of the Company will not
constitute  an  interruption  of  Continuous  Service.  The  Board or the  chief
executive officer of the Company, in that party's sole discretion, may determine
whether Continuous  Service shall be considered  interrupted in the case of: (i)
any leave of absence  approved by that  party,  including  sick leave,  military
leave,  or any other personal  leave;  provided,  however,  that for purposes of
Incentive Stock Options,  any such leave may not exceed ninety (90) days, unless
reemployment  upon the  expiration  of such  leave  is  guaranteed  by  contract
(including  certain  Company  policies) or statute;  or (ii)  transfers  between
locations of the Company or between the Company, Affiliates or its successor.

         (h) "Covered  Employee" means the chief executive  officer and the four
(4)  other  highest   compensated   officers  of  the  Company  for  whom  total
compensation is required to be reported to stockholders  under the Exchange Act,
as determined for purposes of Section 162(m) of the Code.

         (i)  "Director" means a member of the Board.

         (j)  "Disability"  means total and  permanent  disability as defined in
Section 22(e)(3) of the Code.

         (k)  "Employee"  means any person,  including  Officers and  Directors,
employed by the Company or any  Affiliate of the Company.  Neither  service as a
Director nor payment of a director's  fee by the Company  shall be sufficient to
constitute "employment" by the Company.

         (l)  "Exchange  Act"  means the  Securities  Exchange  Act of 1934,  as
amended.

         (m) "Fair Market Value" means,  as of any date, the value of the common
stock of the Company determined as follows:

                  (1) If the  common  stock is listed on any  established  stock
exchange or a national market system,  including without limitation the National
Market System of the National Association of Securities Dealers,  Inc. Automated
Quotation  ("Nasdaq")  System,  the Fair Market Value of a share of common stock
shall be the  closing  sales  price for such  stock as quoted on such  system or
exchange (or the exchange  with the greatest  volume of trading in common stock)
on the last market trading day prior to the day of determination, as reported in
the Wall Street Journal or such other source as the Board deems reliable;

                  (2) If the common  stock is quoted on the Nasdaq  System  (but
not  on  the  National  Market  System  thereof)  or is  regularly  quoted  by a
recognized  securities  dealer but  selling  prices are not  reported,  the Fair
Market  Value of a share of common  stock shall be the mean between the high bid
and high asked prices for the common stock on the last market  trading day prior
to the day of  determination,  as reported  in the Wall  Street  Journal or such
other source as the Board deems reliable;

                  (3) In the  absence  of an  established  market for the common
stock, the Fair Market Value shall be determined in good faith by the Board.

         (n) "Incentive  Stock Option" means an Option intended to qualify as an
incentive  stock  option  within the  meaning of Section 422 of the Code and the
regulations promulgated thereunder.

         (o) "Nonstatutory Stock Option" means an Option not intended to qualify
as an Incentive Stock Option.

         (p)  "Officer"  means a person who is an officer of the Company  within
the  meaning  of Section 16 of the  Exchange  Act and the rules and  regulations
promulgated thereunder.

<PAGE>

         (q) "Option" means a stock option granted pursuant to the Plan.

         (r) "Option  Agreement" means a written  agreement  between the Company
and an Optionee  evidencing  the terms and  conditions of an  individual  Option
grant. The Option Agreement is subject to the terms and conditions of the Plan.

         (s) "Optioned  Stock" means the common stock of the Company  subject to
an Option.

         (t) "Optionee"  means an Employee,  Director or Consultant who holds an
outstanding Option.

         (u) "Outside Director" means a Director who either (i) is not a current
employee of the Company or an  "affiliated  corporation"  (within the meaning of
the Treasury regulations promulgated under Section 162(m) of the Code), is not a
former  employee  of  the  Company  or  an  "affiliated  corporation"  receiving
compensation  for prior  services  (other than  benefits  under a tax  qualified
pension plan), was not an officer of the Company or an "affiliated  corporation"
at any time, and is not currently receiving direct or indirect remuneration from
the Company or an  "affiliated  corporation"  for services in any capacity other
than as a Director,  or (ii) is otherwise  considered an "outside  director" for
purposes of Section 162(m) of the Code.

         (v) "Plan" means this SUGEN, Inc. 1992 Stock Option Plan.

         (w) "Rule 16b-3" means Rule 16b-3 of the Exchange Act or any  successor
to Rule 16b-3,  as in effect when  discretion is being exercised with respect to
the Plan.

         (x) "Securities Act" means the Securities Act of 1933, as amended.


3.       ADMINISTRATION.

         (a) The Board  shall  administer  the Plan  unless  and until the Board
delegates administration to a Committee, as provided in subsection 3(c).

         (b) The  Board  shall  have the  power,  subject  to,  and  within  the
limitations of, the express provisions of the Plan:

                  (1) To  determine  from  time to  time  which  of the  persons
eligible under the Plan shall be granted Options;  when and how the Option shall
be  granted;  whether  the  Option  will  be  an  Incentive  Stock  Option  or a
Nonstatutory Stock Option; the provisions of each Option granted (which need not
be identical), including the time or times such Option may be exercised in whole
or in part;  and the  number of shares  for which an Option  shall be granted to
each such person.

                  (2) To construe  and  interpret  the Plan and Options  granted
under it, and to  establish,  amend and  revoke  rules and  regulations  for its
administration.  The Board,  in the  exercise  of this  power,  may  correct any
defect,  omission or inconsistency in the Plan or in any Option Agreement,  in a
manner and to the extent it shall deem  necessary  or expedient to make the Plan
fully effective.

                  (3) To amend the Plan as provided in Section 11.

                  (4)  Generally,  to exercise  such powers and to perform  such
acts as the Board deems  necessary or expedient to promote the best interests of
the Company.

<PAGE>

         (c) The Board may  delegate  administration  of the Plan to a committee
composed of not fewer than two (2) members (the "Committee"), all of the members
of which Committee may be, in the discretion of the Board, Outside Directors. If
administration  is  delegated  to a  Committee,  the  Committee  shall have,  in
connection with the administration of the Plan, the powers theretofore possessed
by the Board (and  references  in this Plan to the Board shall  thereafter be to
the Committee), subject, however, to such resolutions, not inconsistent with the
provisions  of the Plan,  as may be adopted from time to time by the Board.  The
Board  may  abolish  the  Committee  at any time and  revest  in the  Board  the
administration  of the Plan.  Notwithstanding  anything in this Section 3 to the
contrary,  the Board or the Committee may delegate to a committee of one or more
members of the Board the authority to grant Options to eligible  persons who (1)
are not then subject to Section 16 of the Exchange Act and/or (2) are either (i)
not then Covered  Employees and are not expected to be Covered  Employees at the
time of  recognition of income  resulting from such Option,  or (ii) not persons
with  respect to whom the Company  wishes to comply with  Section  162(m) of the
Code.

4.       SHARES SUBJECT TO THE PLAN.

         (a) Subject to the  provisions  of Section 10  relating to  adjustments
upon changes in stock,  the stock that may be sold pursuant to Options shall not
exceed in the  aggregate  four million two hundred  fifty  thousand  (4,250,000)
shares of the Company's  common stock. If any Option shall for any reason expire
or otherwise  terminate  without  having been  exercised in full,  the stock not
purchased under such Option shall again become available for the Plan.

         (b) The stock subject to the Plan may be unissued  shares or reacquired
shares, bought on the market or otherwise.

5.       ELIGIBILITY.

         (a)  Incentive   Stock  Options  may  be  granted  only  to  Employees.
Nonstatutory  Stock  Options  may be granted  only to  Employees,  Directors  or
Consultants.

         (b) No person  shall be eligible  for the grant of an Option if, at the
time of grant,  such person owns (or is deemed to own pursuant to Section 424(d)
of the Code) stock  possessing more than ten percent (10%) of the total combined
voting power of all classes of stock of the Company or of any of its  Affiliates
unless the  exercise  price of such  Option is at least one  hundred ten percent
(110%)  of the  Fair  Market  Value of such  stock at the date of grant  and the
Option is not  exercisable  after the expiration of five (5) years from the date
of grant.

         (c) Subject to the  provisions  of Section 10  relating to  adjustments
upon  changes  in stock,  no person  shall be  eligible  to be  granted  Options
covering  more than five percent  (5%) of the number of shares of the  Company's
common  stock that was  outstanding  on the record date for the  Company's  1995
Annual Stockholder Meeting (i.e., four hundred thirty-four thousand five hundred
twenty-seven (434,527) shares) in any calendar year.

6.       OPTION PROVISIONS.

         Each  Option  shall be in such form and shall  contain  such  terms and
conditions  as the Board  shall deem  appropriate.  The  provisions  of separate
Options  need  not  be  identical,   but  each  Option  shall  include  (through
incorporation of provisions  hereof by reference in the Option or otherwise) the
substance of each of the following provisions:

         (a) Term. No Option shall be  exercisable  after the  expiration of ten
(10) years from the date it was granted.

<PAGE>

         (b) Price.  The exercise price of each Incentive  Stock Option shall be
not less than one hundred  percent  (100%) of the fair market value of the stock
subject to the Option on the date the Option is granted.  The exercise  price of
each Nonstatutory Stock Option shall be not less than eighty-five  percent (85%)
of the fair  market  value of the stock  subject  to the  Option on the date the
Option is granted.  Notwithstanding  the  foregoing,  the exercise price of each
Option shall be not less than one hundred ten percent  (110%) of the Fair Market
Value of the stock  subject  to the  Option on the date the Option is granted if
the  person to whom the Option is granted  owns stock  possessing  more than ten
percent  (10%) of the total  combined  voting power of all classes of stock,  as
described in subsection 5(b).

         (c) Consideration.  The purchase price of stock acquired pursuant to an
Option  shall be paid,  to the  extent  permitted  by  applicable  statutes  and
regulations,  either (i) in cash at the time the option is exercised, or (ii) at
the discretion of the Board or the Committee, either at the time of the grant or
exercise of the Option,  (A) by delivery to the Company of other common stock of
the Company, (B) according to a deferred payment or other arrangement (which may
include,  without  limiting the  generality of the  foregoing,  the use of other
common stock of the Company) with the person to whom the Option is granted or to
whom the Option is transferred  pursuant to subsection 6(d), or (C) in any other
form of legal  consideration  that may be  acceptable  to the  Board;  provided,
however, that at any time that the Company is incorporated in Delaware,  payment
of  the  Common  Stock's  "par  value,"  as  defined  in  the  Delaware  General
Corporation Law, shall not be made by deferred payment.

         In the case of any  deferred  payment  arrangement,  interest  shall be
compounded  at least  annually  and  shall be  charged  at the  minimum  rate of
interest  necessary to avoid the  treatment as  interest,  under any  applicable
provisions of the Code, of any amounts other than amounts  stated to be interest
under the deferred payment arrangement.

         (d)   Transferability.   An   Incentive   Stock  Option  shall  not  be
transferable  except by will or by the laws of  descent  and  distribution,  and
shall be  exercisable  during the  lifetime of the person to whom the  Incentive
Stock Option is granted only by such person.  A Nonstatutory  Stock Option shall
not be transferable except by will or by the laws of descent and distribution or
pursuant to a qualified domestic relations order as defined by the Code or Title
I of the Employee  Retirement  Income  Security  Act,  and shall be  exercisable
during the  lifetime  of the  person to whom the Option is granted  only by such
person or any  transferee  pursuant to a QDRO.  The person to whom the Option is
granted may, by delivering written notice to the Company, in a form satisfactory
to the  Company,  designate  a third party who, in the event of the death of the
Optionee, shall thereafter be entitled to exercise the Option.

         (e) Vesting.  The total number of shares of stock  subject to an Option
may,  but need not, be allotted in periodic  installments  (which may,  but need
not, be equal).  The Option  Agreement may provide that from time to time during
each of such installment  periods,  the Option may become  exercisable  ("vest")
with respect to some or all of the shares  allotted to that  period,  and may be
exercised  with  respect to some or all of the shares  allotted  to such  period
and/or any prior period as to which the Option  became  vested but was not fully
exercised.  During the  remainder of the term of the Option (if its term extends
beyond the end of the  installment  periods),  the option may be exercised  from
time to time with  respect to any shares then  remaining  subject to the Option.
The  provisions  of this  subsection  6(e) are subject to any Option  provisions
governing the minimum number of shares as to which an Option may be exercised.

         (f) Securities Law Compliance. The Company may require any Optionee, or
any  person  to whom an  Option  is  transferred  under  subsection  6(d),  as a
condition  of  exercising  any  such  Option,  (1) to  give  written  assurances
satisfactory  to the Company as to the  Optionee's  knowledge and  experience in
financial  and  business  matters  and/or to employ a  purchaser  representative
reasonably  satisfactory to the Company who is knowledgeable  and experienced in
financial  and business  matters,  and that he or she is capable of  evaluating,
alone or together  with the  purchaser  representative,  the merits and risks of
exercising the Option;  and (2) to give written  assurances  satisfactory to the
Company  stating that such person is acquiring  the stock  subject to the Option
for such  person's own account and not with any present

<PAGE>

intention of selling or otherwise  distributing the stock.  These  requirements,
and any assurances given pursuant to such requirements,  shall be inoperative if
(i) the  issuance  of the  shares  upon  the  exercise  of the  Option  has been
registered  under a then currently  effective  registration  statement under the
Securities Act, or (ii) as to any particular  requirement,  a  determination  is
made by counsel for the  Company  that such  requirement  need not be met in the
circumstances under the then applicable securities laws.

         (g)  Termination  of  Continuous  Service.  In the event an  Optionee's
Continuous   Service  terminates  (other  than  upon  the  Optionee's  death  or
Disability),  the Optionee may exercise his or her Option,  but only within such
period of time as is  determined  by the Board,  and only to the extent that the
Optionee was entitled to exercise it at the date of termination (but in no event
later than the  expiration of the term of such Option as set forth in the Option
Agreement).  In the case of an Incentive Stock Option, the Board shall determine
such period of time  (generally  not to exceed three (3) months from the date of
termination)  when the Option is granted.  If, at the date of  termination,  the
Optionee  is not  entitled  to  exercise  his or her entire  Option,  the shares
covered by the unexercisable portion of the Option shall revert to the Plan. If,
after  termination,  the Optionee does not exercise his or her Option within the
time  specified in the Option  Agreement,  the Option shall  terminate,  and the
shares covered by such Option shall revert to the Plan.

         (h)  Disability  of  Optionee.  In the event an  Optionee's  Continuous
Service  terminates as a result of the Optionee's  Disability,  the Optionee may
exercise his or her Option,  but only within twelve (12) months from the date of
such termination (or such shorter period specified in the Option Agreement), and
only to the extent that the  Optionee was entitled to exercise it at the date of
such  termination (but in no event later than the expiration of the term of such
Option as set forth in the Option  Agreement).  If, at the date of  termination,
the Optionee is not entitled to exercise  his or her entire  Option,  the shares
covered by the unexercisable portion of the Option shall revert to the Plan. If,
after  termination,  the Optionee does not exercise his or her Option within the
time specified  herein,  the Option shall  terminate,  and the shares covered by
such Option shall revert to the Plan.

         (i) Death of Optionee.  In the event of the death of an  Optionee,  the
Option may be  exercised,  at any time within  twelve (12) months  following the
date of death (or such shorter period specified in the Option Agreement) (but in
no event  later than the  expiration  of the term of such Option as set forth in
the Option Agreement),  by the Optionee's estate or by a person who acquired the
right to exercise the Option by bequest or  inheritance,  but only to the extent
the Optionee  was  entitled to exercise the Option at the date of death.  If, at
the time of death,  the  Optionee was not entitled to exercise his or her entire
Option,  the shares  covered by the  unexercisable  portion of the Option  shall
revert to the Plan.  If,  after  death,  the  Optionee's  estate or a person who
acquired  the right to exercise  the Option by bequest or  inheritance  does not
exercise  the  Option  within  the  time  specified  herein,  the  Option  shall
terminate, and the shares covered by such Option shall revert to the Plan.

         (j) Early Exercise.  The Option may, but need not,  include a provision
whereby  the  Optionee  may elect at any time  while an  Employee,  Director  or
Consultant to exercise the Option as to any part or all of the shares subject to
the Option  prior to the full  vesting of the  Option.  Any  unvested  shares so
purchased  shall be subject to a repurchase  right in favor of the Company or to
any other restriction the Board determines to be appropriate.  The Company shall
exercise its repurchase option to the extent permitted by applicable law.

         (k)  Withholding.  To the  extent  provided  by the  terms of an Option
Agreement,  the Optionee may satisfy any federal, state or local tax withholding
obligation relating to the exercise of such Option by any of the following means
or by a combination of such means: (1) tendering a cash payment; (2) authorizing
the Company to withhold  shares  from the shares of the common  stock  otherwise
issuable to the  participant  as a result of the exercise of the Option;  or (3)
delivering to the Company owned and  unencumbered  shares of the common stock of
the Company.

<PAGE>

7.       COVENANTS OF THE COMPANY.

         (a) During the terms of the Options,  the Company shall keep  available
at all times the number of shares of stock required to satisfy such Options.

         (b) The Company shall seek to obtain from each regulatory commission or
agency having  jurisdiction  over the Plan such  authority as may be required to
issue and sell shares of stock upon exercise of the Options; provided,  however,
that this  undertaking  shall not  require  the  Company to  register  under the
Securities  Act either  the Plan,  any  Option or any stock  issued or  issuable
pursuant to any such Option. If, after reasonable efforts, the Company is unable
to obtain from any such  regulatory  commission  or agency the  authority  which
counsel for the Company  deems  necessary  for the lawful  issuance  and sale of
stock under the Plan,  the  Company  shall be relieved  from any  liability  for
failure to issue and sell stock upon  exercise of such Options  unless and until
such authority is obtained.

8.       USE OF PROCEEDS FROM STOCK.

         Proceeds from the sale of stock  pursuant to Options  shall  constitute
general funds of the Company.

9.       MISCELLANEOUS.

         (a) The Board shall have the power to  accelerate  the time at which an
Option may first be  exercised  or the time  during  which an Option or any part
thereof will vest pursuant to subsection 6(e), notwithstanding the provisions in
the  Option  stating  the time at which it may  first be  exercised  or the time
during which it will vest.

         (b) Neither an Optionee nor any person to whom an Option is transferred
under subsection 6(d) shall be deemed to be the holder of, or to have any of the
rights of a holder with respect to, any shares subject to such Option unless and
until such person has  satisfied  all  requirements  for  exercise of the Option
pursuant to its terms.

         (c) Throughout the term of any Option, the Company shall deliver to the
holder of such  Option,  not later than one hundred  twenty (120) days after the
close of each of the  Company's  fiscal  years  during  the  Option  term,  such
financial  and other  information  regarding the Company as comprises the annual
report to the  stockholders  of the  Company  provided  for in the bylaws of the
Company.

         (d) Nothing in the Plan or any  instrument  executed or Option  granted
pursuant  thereto  shall  confer  upon any  Employee,  Director,  Consultant  or
Optionee any right to continue in the employ of the Company or any Affiliate (or
to continue acting as a Director or Consultant) or shall affect the right of the
Company or any  Affiliate to  terminate  the  employment  or  relationship  as a
Director or Consultant of any Employee, Director, Consultant or Optionee with or
without cause.

         (e) To the extent that the aggregate  Fair Market Value  (determined at
the time of  grant) of stock  with  respect  to which  Incentive  Stock  Options
granted after 1986 are exercisable for the first time by any Optionee during any
calendar  year under all plans of the  Company  and its  Affiliates  exceeds one
hundred  thousand  dollars  ($100,000),  the Options or portions  thereof  which
exceed such limit  (according to the order in which they were granted)  shall be
treated as Nonstatutory Stock Options.

         (f) If an Option is canceled, or deemed to be canceled, for purposes of
Section 162(m) of the Code and the regulations promulgated thereunder,  then the
number of shares subject to the canceled  Option shall continue to count towards
the  maximum  number of shares  which may be granted to any person  pursuant  to
subsection  5(c) of the Plan.  The provisions of this  subsection  9(f) shall be
applicable only to the extent required by Section 162(m) of the Code.

<PAGE>

10.      ADJUSTMENTS UPON CHANGES IN STOCK.

         (a) If any change is made in the stock  subject to the Plan, or subject
to any Option (through merger, consolidation, reorganization,  recapitalization,
stock dividend,  dividend in property other than cash, stock split,  liquidating
dividend,  combination  of  shares,  exchange  of  shares,  change in  corporate
structure or otherwise),  the Plan and outstanding Options will be appropriately
adjusted in the class(es) and maximum  number of shares  subject to the Plan and
the  class(es)  and  number of shares  and price per share of stock  subject  to
outstanding Options.

         (b) In the event of: (1) a merger or consolidation in which the Company
is not the surviving  corporation;  (2) a reverse merger in which the Company is
the  surviving  corporation  but  the  shares  of  the  Company's  common  stock
outstanding  immediately  preceding  the merger are  converted  by virtue of the
merger  into  other  property,  whether  in the  form  of  securities,  cash  or
otherwise; (3) any other capital reorganization in which more than fifty percent
(50%)  of the  shares  of the  Company  entitled  to vote are  exchanged;  (4) a
transaction  or  group  of  related  transactions  involving  the sale of all or
substantially  all of the Company's  assets;  (5) the acquisition by any person,
entity  or group  (excluding  any  employee  benefit  plan,  or  related  trust,
sponsored or maintained by the Company or any  subsidiary of the Company) of the
beneficial  ownership,  directly or  indirectly,  of  securities  of the Company
representing  more than fifty percent (50%) of the combined  voting power in the
election of directors; or (6) a change in the composition of the Company's Board
of Directors such that, during any period of two consecutive years,  individuals
who, at the  beginning  of such  period,  constitute  the Board,  together  with
individuals  who are Approved New  Directors (as defined  below),  cease for any
reason to have  authority  to cast at least a  majority  of the votes  which all
directors on the Board are entitled to vote;  then, to the extent not prohibited
by law,  the  time  during  which  Options  outstanding  under  the  Plan may be
exercised  shall  be  accelerated  prior to such  event.  For  purposes  of this
subsection  10(b),  an  Approved  New  Director  shall be a Board  member  whose
election,  or the  nomination  for election by the Company's  stockholders,  was
approved by a vote of a majority of the votes  entitled to be cast by  directors
then still in office who were directors at the beginning of the period.

11.      AMENDMENT OF THE PLAN AND OPTIONS.

         (a) The Board at any time,  and from time to time,  may amend the Plan.
However,  except as provided in Section 10 relating to adjustments  upon changes
in stock, no amendment shall be effective unless approved by the stockholders of
the  Company  within  twelve  (12)  months  before or after the  adoption of the
amendment, where the amendment will:

                  (1) Increase the number of shares  reserved for Options  under
the Plan;

                  (2)   Modify   the   requirements   as  to   eligibility   for
participation in the Plan (to the extent such modification  requires stockholder
approval in order for the Plan to satisfy the requirements of Section 422 of the
Code); or

                  (3)  Modify  the Plan in any  other  way if such  modification
requires  stockholder approval in order for the Plan to satisfy the requirements
of Section 422 of the Code or to comply with the  requirements  of Rule 16b-3 or
any Nasdaq or securities exchange listing requirements.

         (b) The Board may in its sole discretion  submit any other amendment to
the Plan for stockholder approval,  including, but not limited to, amendments to
the Plan intended to satisfy the  requirements of Section 162(m) of the Code and
the   regulations    promulgated   thereunder   regarding   the   exclusion   of
performance-based  compensation  from the limit on  corporate  deductibility  of
compensation paid to certain executive officers.

<PAGE>

         (c) It is expressly  contemplated  that the Board may amend the Plan in
any respect the Board deems necessary or advisable to provide Optionees with the
maximum benefits provided or to be provided under the provisions of the Code and
the  regulations  promulgated  thereunder  relating to Incentive  Stock  Options
and/or to bring the Plan and/or  Incentive  Stock Options  granted under it into
compliance therewith.

         (d) Rights and obligations under any Option granted before amendment of
the Plan  shall not be  impaired  by any  amendment  of the Plan  unless (i) the
Company  requests  the  consent of the person to whom the Option was granted and
(ii) such person consents in writing.

         (e) The Board at any time,  and from time to time,  may amend the terms
of any one or more Options;  provided,  however, that the rights and obligations
under any Option  shall not be  impaired  by any such  amendment  unless (i) the
Company  requests  the  consent of the person to whom the Option was granted and
(ii) such person consents in writing.

12.      TERMINATION OR SUSPENSION OF THE PLAN.

         (a) The Board may  suspend or  terminate  the Plan at any time.  Unless
sooner terminated,  the Plan shall terminate on February 27, 2002 which shall be
within ten (10) years from the date the Plan is adopted by the Board or approved
by the  stockholders  of the Company,  whichever  is earlier.  No Options may be
granted under the Plan while the Plan is suspended or after it is terminated.

         (b) Rights and  obligations  under any Option granted while the Plan is
in effect shall not be impaired by suspension or termination of the Plan, except
with the consent of the person to whom the Option was granted.

13.      EFFECTIVE DATE OF PLAN.

         The Plan shall become  effective  as  determined  by the Board,  but no
Options  granted to acquire shares of the Company's  common stock under the Plan
shall be  exercised  unless and until the issuance of such shares under the Plan
has been approved by the stockholders of the Company.

<PAGE>

                                  PLAN HISTORY

Adopted February 28, 1992
Amended effective as of February 5, 1993
Amended by the Board of Directors on January 7, 1994 and April 12, 1994
Amended by the Board of Directors on February 24, 1995 and May 1, 1995
Approved by Stockholders on June 6, 1995
Amended by the Board of Directors on December 19, 1995
Approved by the Stockholders on May 23, 1996
Amended by the Board of Directors on December 10, 1996
Approved by the Stockholders on May 21, 1997
Amended by the Board of Directors on February 19, 1998
Approved by Stockholders on May 20, 1998
Amended by the Board of Directors on February 22, 1999
Approved by the Stockholders on May 19, 1999
Amended by the Board of Directors on June 15, 1999
Stockholder Approval Not Required



                                                                    Exhibit 99.2

                                   SUGEN, INC.

                          EMPLOYEE STOCK PURCHASE PLAN

                             Adopted April 12, 1994
                             Effective April 1, 1995
                         Termination Date April 12, 2004


1.       PURPOSE.

         (a) The purpose of the Employee  Stock Purchase Plan (the "Plan") is to
provide a means by which employees of Sugen,  Inc., a Delaware  corporation (the
"Company"),  and its  Affiliates,  as defined in  subparagraph  1(b),  which are
designated as provided in  subparagraph  2(b),  may be given an  opportunity  to
purchase stock of the Company.

         (b)  The  word  "Affiliate"  as  used  in the  Plan  means  any  parent
corporation or subsidiary corporation of the Company, as those terms are defined
in Sections 424(e) and (f), respectively,  of the Internal Revenue Code of 1986,
as amended (the "Code").

         (c) The Company,  by means of the Plan, seeks to retain the services of
its  employees,  to secure and  retain the  services  of new  employees,  and to
provide  incentives for such persons to exert maximum efforts for the success of
the Company.

         (d) The  Company  intends  that the  rights  to  purchase  stock of the
Company  granted under the Plan be considered  options issued under an "employee
stock purchase plan" as that term is defined in Section 423(b) of the Code.

2.       ADMINISTRATION.

         (a) The Plan  shall be  administered  by the  Board of  Directors  (the
"Board") of the Company unless and until the Board delegates administration to a
Committee,  as  provided  in  subparagraph  2(c).  Whether  or not the Board has
delegated administration,  the Board shall have the final power to determine all
questions of policy and expediency that may arise in the  administration  of the
Plan.

         (b) The  Board  shall  have the  power,  subject  to,  and  within  the
limitations of, the express provisions of the Plan:

                  (i) To determine  when and how rights to purchase stock of the
Company  shall be granted  and the  provisions  of each  offering of such rights
(which need not be identical).

<PAGE>

                  (ii) To designate  from time to time which  Affiliates  of the
Company shall be eligible to participate in the Plan.

                  (iii) To construe and  interpret  the Plan and rights  granted
under it, and to  establish,  amend and  revoke  rules and  regulations  for its
administration.  The Board,  in the  exercise  of this  power,  may  correct any
defect,  omission or inconsistency in the Plan, in a manner and to the extent it
shall deem necessary or expedient to make the Plan fully effective.

                  (iv) To amend the Plan as provided in paragraph 13.

                  (v)  Generally,  to exercise  such powers and to perform  such
acts as the Board deems  necessary or expedient to promote the best interests of
the Company.

         (c) The Board may  delegate  administration  of the Plan to a Committee
composed  of not fewer than two (2) members of the Board (the  "Committee").  If
administration  is  delegated  to a  Committee,  the  Committee  shall have,  in
connection with the administration of the Plan, the powers theretofore possessed
by the Board, subject,  however, to such resolutions,  not inconsistent with the
provisions  of the Plan,  as may be adopted from time to time by the Board.  The
Board  may  abolish  the  Committee  at any time and  revest  in the  Board  the
administration of the Plan.

3.       SHARES SUBJECT TO THE PLAN.

         (a) Subject to the  provisions of paragraph 12 relating to  adjustments
upon  changes in stock,  the stock that may be sold  pursuant to rights  granted
under the Plan shall not exceed in the aggregate four hundred  (400,000)  shares
of the Company's common stock (the "Common  Stock").  If any right granted under
the Plan shall for any reason  terminate  without  having  been  exercised,  the
Common Stock not purchased under such right shall again become available for the
Plan.

         (b) The stock subject to the Plan may be unissued  shares or reacquired
shares, bought on the market or otherwise.

4.       GRANT OF RIGHTS; OFFERING.

         The Board or the  Committee  may from time to time grant or provide for
the grant of rights to purchase  Common  Stock of the Company  under the Plan to
eligible  employees (an "Offering") on a date or dates (the "Offering  Date(s)")
selected by the Board or the Committee.  Each Offering shall be in such form and
shall contain such terms and conditions as the Board or the Committee shall deem
appropriate.  The provisions of separate  Offerings  need not be identical,  but
each Offering  shall include  (through  incorporation  of the provisions of this
Plan by reference in the Offering or otherwise)  the substance of the provisions
contained in paragraphs 5 through 8, inclusive.

<PAGE>

5.       ELIGIBILITY.

         (a) Rights may be granted  only to  employees of the Company or, as the
Board or the  Committee  may  designate  as provided in  subparagraph  2(b),  to
employees of any  Affiliate of the Company.  Except as provided in  subparagraph
5(b),  an employee of the Company or any  Affiliate  shall not be eligible to be
granted rights under the Plan,  unless,  on the Offering Date, such employee has
been in the employ of the Company or any  Affiliate for such  continuous  period
preceding such grant as the Board or the Committee may require,  but in no event
shall the required  period of continuous  employment be equal to or greater than
two (2) years.  In addition,  unless  otherwise  determined  by the Board or the
Committee and set forth in the terms of the applicable Offering,  no employee of
the Company or any  Affiliate  shall be eligible to be granted  rights under the
Plan,  unless, on the Offering Date, such employee's  customary  employment with
the  Company or such  Affiliate  is at least  twenty  (20) hours per week and at
least five (5) months per calendar year.

         (b) The Board or the Committee may provide that each person who, during
the course of an Offering,  first becomes an eligible employee of the Company or
designated  Affiliate  will, on a date or dates  specified in the Offering which
coincides  with the day on which such  person  becomes an  eligible  employee or
occurs  thereafter,  receive a right  under that  Offering,  which  right  shall
thereafter  be deemed to be a part of that  Offering.  Such right shall have the
same  characteristics as any rights originally  granted under that Offering,  as
described herein, except that:

                  (i) the  date on which  such  right  is  granted  shall be the
"Offering Date" of such right for all purposes,  including  determination of the
exercise price of such right;

                  (ii) the  Offering  Period for such right  shall  begin on its
Offering Date and end coincident with the end of such Offering; and

                  (iii)  the Board or the  Committee  may  provide  that if such
person  first  becomes an eligible  employee  within a specified  period of time
before  the end of the  Offering  Period for such  Offering,  he or she will not
receive any right under that Offering.

         (c) No employee shall be eligible for the grant of any rights under the
Plan if, immediately after any such rights are granted, such employee owns stock
possessing five percent (5%) or more of the total combined voting power or value
of all classes of stock of the Company or of any Affiliate. For purposes of this
subparagraph  5(c),  the  rules of  Section  424(d) of the Code  shall  apply in
determining the stock  ownership of any employee,  and stock which such employee
may purchase under all outstanding  rights and options shall be treated as stock
owned by such employee.

         (d) An eligible  employee may be granted  rights under the Plan only if
such  rights,  together  with any other rights  granted  under  "employee  stock
purchase  plans" of the  Company and any  Affiliates,  as  specified  by Section
423(b)(8) of the Code, do not permit such employee's

<PAGE>

rights to  purchase  stock of the Company or any  Affiliate  to accrue at a rate
which exceeds  twenty-five  thousand  dollars  ($25,000) of fair market value of
such stock  (determined  at the time such rights are granted) for each  calendar
year in which such rights are outstanding at any time.

         (e)  Officers  of the  Company and any  designated  Affiliate  shall be
eligible to participate in Offerings under the Plan, provided, however, that the
Board  may  provide  in an  Offering  that  certain  employees  who  are  highly
compensated  employees  within the meaning of Section  423(b)(4)(D)  of the Code
shall not be eligible to participate.

6.       RIGHTS; PURCHASE PRICE.

         (a) On each  Offering  Date,  each  eligible  employee,  pursuant to an
Offering  made under the Plan,  shall be granted the right to purchase up to the
number of shares of Common  Stock of the Company  purchasable  with a percentage
designated by the Board or the Committee not exceeding  fifteen percent (15%) of
such  employee's  Earnings (as defined in Section  7(a)) during the period which
begins on the  Offering  Date (or such later date as the Board or the  Committee
determines  for a  particular  Offering)  and  ends on the  date  stated  in the
Offering,  which date shall be no more than  twenty-seven  (27) months after the
Offering Date (the  "Offering  Period").  In connection  with each Offering made
under this Plan,  the Board or the Committee  shall specify a maximum  number of
shares which may be  purchased  by any  employee as well as a maximum  aggregate
number of shares which may be purchased  by all eligible  employees  pursuant to
such Offering. In addition, in connection with each Offering which contains more
than one Purchase Date (as defined in the Offering),  the Board or the Committee
may specify a maximum  aggregate  number of shares which may be purchased by all
eligible  employees  on any  given  Purchase  Date  under the  Offering.  If the
aggregate  purchase of shares upon exercise of rights granted under the Offering
would exceed any such maximum aggregate number, the Board or the Committee shall
make a pro rata allocation of the shares available in as nearly a uniform manner
as shall be practicable and as it shall deem to be equitable.

         (b) The purchase  price of stock  acquired  pursuant to rights  granted
under the Plan shall be not less than the lesser of:

                  (i) an amount equal to  eighty-five  percent (85%) of the fair
market value of the stock on the Offering Date; or

                  (ii) an amount equal to eighty-five  percent (85%) of the fair
market value of the stock on the Purchase Date.

7.       PARTICIPATION; WITHDRAWAL; TERMINATION.

         (a) An eligible  employee  may become a  participant  in an Offering by
delivering a participation agreement to the Company within the time specified in
the Offering,  in such form as the Company  provides.  Each such agreement shall
authorize payroll  deductions of up to the

<PAGE>

maximum  percentage  specified by the Board or the Committee of such  employee's
Earnings  during  the  Offering  Period.  "Earnings"  is  defined  as the  total
compensation paid to an employee, including all salary, wages (including amounts
elected to be deferred by the  employee,  that would  otherwise  have been paid,
under any cash or deferred  arrangement  established  by the Company),  overtime
pay,  commissions,  and other  remuneration  paid directly to the employee,  but
excluding bonuses, profit sharing, the cost of employee benefits paid for by the
Company,  education or tuition reimbursements,  imputed income arising under any
Company group insurance or benefit  program,  traveling  expenses,  business and
moving expense reimbursements, income received in connection with stock options,
contributions  made by the Company under any employee  benefit plan, and similar
items of compensation. The payroll deductions made for each participant shall be
credited  to an  account  for such  participant  under  the  Plan  and  shall be
deposited  with the  general  funds of the  Company.  A  participant  may reduce
(including  to  zero),  increase  or begin  such  payroll  deductions  after the
beginning of any Offering only as provided for in the Offering.

         (b) At any time during an Offering  Period a participant  may terminate
his or her payroll  deductions  under the Plan and withdraw from the Offering by
delivering  to the  Company a notice of  withdrawal  in such form as the Company
provides.  Such  withdrawal  may be  elected at any time prior to the end of the
Offering  Period  except  as  provided  by the  Board  or the  Committee  in the
Offering.  Upon such withdrawal from the Offering by a participant,  the Company
shall  distribute  to such  participant  all of his or her  accumulated  payroll
deductions  (reduced to the extent,  if any, such  deductions  have been used to
acquire stock for the participant)  under the Offering,  without  interest,  and
such participant's interest in that Offering shall be automatically  terminated.
A  participant's  withdrawal  from an  Offering  will have no  effect  upon such
participant's  eligibility to participate in any other  Offerings under the Plan
but such participant will be required to deliver a new  participation  agreement
in order to participate in subsequent Offerings under the Plan.

         (c)  Rights  granted  pursuant  to any  Offering  under the Plan  shall
terminate immediately upon cessation of any participating  employee's employment
with the Company and any designated  Affiliate,  for any reason, and the Company
shall  distribute  to such  terminated  employee  all of his or her  accumulated
payroll  deductions  (reduced to the extent,  if any, such  deductions have been
used to acquire stock for the terminated employee),  under the Offering, without
interest.

         (d)  Rights  granted  under the Plan  shall not be  transferable,  and,
except as  provided in Section 14,  shall be  exercisable  only by the person to
whom such rights are granted.

8.       EXERCISE.

         (a) On each  purchase  date,  as defined in the  relevant  Offering  (a
"Purchase Date"),  each participant's  accumulated  payroll deductions and other
additional  payments  specifically  provided  for in the  Offering  (without any
increase for interest)  will be applied to the purchase of whole shares of stock
of the Company,  up to the maximum  number of shares  permitted  pursuant

<PAGE>

to the terms of the Plan and the  applicable  Offering,  at the  purchase  price
specified  in the  Offering.  No  fractional  shares  shall be  issued  upon the
exercise of rights  granted under the Plan.  The amount,  if any, of accumulated
payroll deductions remaining in each participant's account after the purchase of
shares which is less than the amount  required to purchase one share of stock on
the final Purchase Date of an Offering shall be held in each such  participant's
account  for the  purchase  of shares  under the next  Offering  under the Plan,
unless  such  participant  withdraws  from such next  Offering,  as  provided in
subparagraph 7(b), or is no longer eligible to be granted rights under the Plan,
as provided in paragraph 5, in which case such amount  shall be  distributed  to
the participant after the final Purchase Date of the Offering, without interest.
The  amount,  if  any,  of  accumulated  payroll  deductions  remaining  in  any
participant's  account after the purchase of shares which is equal to the amount
required  to purchase  whole  shares of stock on the final  Purchase  Date of an
Offering  shall be distributed  in full to the  participant  after such Purchase
Date, without interest.

         (b) No rights  granted  under the Plan may be  exercised  to any extent
unless the Plan (including rights granted thereunder) is covered by an effective
registration  statement  pursuant to the Securities Act of 1933, as amended (the
"Securities  Act"). If on a Purchase Date of any Offering  hereunder the Plan is
not so  registered,  no rights  granted under the Plan or any Offering  shall be
exercised on said Purchase Date and the Purchase Date shall be delayed until the
Plan is subject to such an  effective  registration  statement,  except that the
Purchase  Date  shall not be delayed  more than two (2) months and the  Purchase
Date shall in no event be more than  twenty-seven  (27) months from the Offering
Date.  If on the  Purchase  Date of any  Offering  hereunder,  as delayed to the
maximum extent permissible,  the Plan is not registered, no rights granted under
the  Plan  or any  Offering  shall  be  exercised  and  all  payroll  deductions
accumulated  during the Offering  Period  (reduced to the extent,  if any,  such
deductions  have  been  used to  acquire  stock)  shall  be  distributed  to the
participants, without interest.

9.       COVENANTS OF THE COMPANY.

         (a) During the terms of the rights  granted under the Plan, the Company
shall  keep  available  at all times the number of shares of stock  required  to
satisfy such rights.

         (b) The Company shall seek to obtain from each regulatory commission or
agency having  jurisdiction  over the Plan such  authority as may be required to
issue and sell  shares of stock upon  exercise of the rights  granted  under the
Plan.  If, after  reasonable  efforts,  the Company is unable to obtain from any
such regulatory commission or agency the authority which counsel for the Company
deems  necessary for the lawful  issuance and sale of stock under the Plan,  the
Company shall be relieved from any liability for failure to issue and sell stock
upon exercise of such rights unless and until such authority is obtained.

10.      USE OF PROCEEDS FROM STOCK.

         Proceeds  from the sale of stock  pursuant to rights  granted under the
Plan shall constitute general funds of the Company.

<PAGE>

11.      RIGHTS AS A STOCKHOLDER.

         A  participant  shall not be deemed to be the holder of, or to have any
of the rights of a holder with respect to, any shares  subject to rights granted
under the Plan unless and until the  participant's  shareholdings  acquired upon
exercise of rights hereunder are recorded in the books of the Company.

12.      ADJUSTMENTS UPON CHANGES IN STOCK.

         (a) If any change is made in the stock  subject to the Plan, or subject
to  any  rights   granted  under  the  Plan  (through   merger,   consolidation,
reorganization,  recapitalization,  stock  dividend,  dividend in property other
than cash, stock split, liquidating dividend, combination of shares, exchange of
shares,  change in corporate  structure or otherwise),  the Plan and outstanding
rights will be  appropriately  adjusted in the class(es)  and maximum  number of
shares  subject to the Plan and the class(es) and number of shares and price per
share of stock subject to outstanding rights.

          (b) In the event of: (1) a dissolution  or liquidation of the Company;
(2) a  merger  or  consolidation  in  which  the  Company  is not the  surviving
corporation;  (3) a  reverse  merger  in  which  the  Company  is the  surviving
corporation but the shares of the Company's Common Stock outstanding immediately
preceding the merger are converted by virtue of the merger into other  property,
whether in the form of securities,  cash or otherwise;  or (4) any other capital
reorganization  in which  more than  fifty  percent  (50%) of the  shares of the
Company entitled to vote are exchanged,  then, as determined by the Board in its
sole discretion (i) any surviving  corporation may assume  outstanding rights or
substitute  similar  rights  for  those  under the Plan,  (ii) such  rights  may
continue in full force and effect, or (iii)  participants'  accumulated  payroll
deductions  may be  used to  purchase  Common  Stock  immediately  prior  to the
transaction  described  above and the  participants'  rights  under the  ongoing
Offering terminated.

13.      AMENDMENT OF THE PLAN.

         (a) The Board at any time,  and from time to time,  may amend the Plan.
However, except as provided in paragraph 12 relating to adjustments upon changes
in stock, no amendment shall be effective unless approved by the stockholders of
the  Company  within  twelve  (12)  months  before or after the  adoption of the
amendment, where the amendment will:

                  (i)  Increase  the number of shares  reserved for rights under
         the Plan;

                  (ii) Modify the provisions as to eligibility for participation
         in the Plan  (to the  extent  such  modification  requires  stockholder
         approval in order for the Plan to obtain  employee  stock purchase plan
         treatment  under  Section  423  of  the  Code  or to  comply  with  the
         requirements of Rule 16b-3  promulgated  under the Securities  Exchange
         Act of 1934, as amended ("Rule 16b-3")); or

<PAGE>

                  (iii)  Modify  the Plan in any other way if such  modification
         requires  stockholder approval in order for the Plan to obtain employee
         stock  purchase  plan  treatment  under  Section  423 of the Code or to
         comply with the requirements of Rule 16b-3.

It is  expressly  contemplated  that the Board may amend the Plan in any respect
the Board deems  necessary or advisable to provide  eligible  employees with the
maximum benefits provided or to be provided under the provisions of the Code and
the regulations promulgated thereunder relating to employee stock purchase plans
and/or  to bring  the  Plan  and/or  rights  granted  under  it into  compliance
therewith.

         (b) Rights and obligations under any rights granted before amendment of
the Plan shall not be altered or impaired by any  amendment of the Plan,  except
with the  consent of the person to whom such  rights  were  granted or except as
necessary to comply with any laws or governmental regulation.

14.      DESIGNATION OF BENEFICIARY.

         (a) A participant  may file a written  designation of a beneficiary who
is to receive any shares and cash, if any, from the participant's  account under
the Plan in the event of such  participant's  death  subsequent to the end of an
Offering but prior to delivery to him of such shares and cash.  In  addition,  a
participant  may file a written  designation of a beneficiary  who is to receive
any cash  from the  participant's  account  under  the Plan in the event of such
participant's death during an Offering Period.

         (b) Such  designation of beneficiary  may be changed by the participant
at any time by written notice. In the event of the death of a participant and in
the absence of a beneficiary  validly designated under the Plan who is living at
the time of such  participant's  death,  the Company  shall  deliver such shares
and/or cash to the executor or  administrator  of the estate of the participant,
or if no such executor or administrator  has been appointed (to the knowledge of
the Company),  the Company,  in its  discretion,  may deliver such shares and/or
cash  to the  spouse  or to any  one or  more  dependents  or  relatives  of the
participant,  or if no spouse,  dependent  or relative is known to the  Company,
then to such other person as the Company may designate.

15.      TERMINATION OR SUSPENSION OF THE PLAN.

         (a) The Board may  suspend or  terminate  the Plan at any time.  Unless
sooner terminated,  the Plan shall terminate on April 12, 2004. No rights may be
granted under the Plan while the Plan is suspended or after it is terminated.

         (b) Rights and  obligations  under any rights granted while the Plan is
in effect shall not be altered or impaired by suspension or  termination  of the
Plan, except with the consent of

<PAGE>

the person to whom such rights  were  granted or except as  necessary  to comply
with any laws or governmental regulation.

16.      EFFECTIVE DATE OF PLAN.

         The Plan shall become  effective  as  determined  by the Board,  but no
rights  granted under the Plan shall be exercised  unless and until the Plan has
been approved by the stockholders of the Company.

<PAGE>

                                  PLAN HISTORY


Adopted April 12, 1994 to be effective upon the Initial Public Offering of
SUGEN, Inc.
Common Stock (October 4, 1994)
Approved by the Stockholders on May 20, 1994

Amended by the Board of Directors on February 23, 1995

Amended by the Board of Directors on February 22, 1999



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