SUGEN INC
10-Q/A, 1999-06-01
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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================================================================================

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549
                          -----------------------------


                                   FORM 10-Q/A
(Mark one)


 X   Quarterly report pursuant to Section 13 or 15(d) of the Securities Exchange
- ---  Act of 1934. For the quarterly period ended March 31, 1999.

                                       or

     Transition  report  pursuant  to  Section  13 or  15(d)  of the  Securities
- ---  Exchange  Act of  1934.  For the  transition  period  from  ___________  to
     ___________.


                             Commission File Number:
                                     0-24814
                          -----------------------------


                                   SUGEN, Inc.
             (Exact name of registrant as specified in its charter)

                  Delaware                                   13-3629196
      (State or other jurisdiction of                    (I.R.S. Employer
      incorporation or organization)                    Identification No.)


          230 East Grand Avenue, South San Francisco, California 94080
                    (address of principal executive offices)

                                 (650) 553-8300
              (Registrant's telephone number, including area code)


                          -----------------------------

Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  registrant  was
required to file such reports),  and (2) has been subject to filing requirements
for the past 90 days. Yes X No


Indicate the number of shares  outstanding  of each of the  issuer's  classes of
common stock, as of the latest  practicable  date.  Common Stock $.01 par value;
16,880,775 shares outstanding at April 30, 1999.


================================================================================


<PAGE>


                                   SUGEN, Inc.

<TABLE>
                                      INDEX

<CAPTION>
                                                                                     PAGE NO.
PART I.  FINANCIAL INFORMATION

<S>              <C>                                                                   <C>
Item 1.          Financial Statements and Notes

                 Condensed Consolidated Balance Sheets - March 31, 1999
                 and December 31, 1998                                                 3

                 Condensed Consolidated Statements of Operations -
                 for the three months ended March 31, 1999 and 1998                    4

                 Condensed Consolidated Statements of Cash Flows - for the three
                 months ended March 31, 1999 and 1998                                  5

                 Notes to Condensed Consolidated Financial Statements                  6

Item 2.          Management's Discussion and Analysis of Financial
                 Condition and Results of Operations                                  10

Item 3.          Quantitative and Qualitative Disclosures About Market Risk           15

PART II. OTHER INFORMATION

Item 2.          Changes in Securities and Use of Proceeds                            16

Item 5.          Other Information                                                    18

Item 6.          Exhibits and Reports on Form 8-K                                     18

Signatures                                                                            20

Exhibit Index                                                                         21

</TABLE>


                                        2


<PAGE>


                                             PART I. FINANCIAL INFORMATION

Item 1.   FINANCIAL STATEMENTS AND NOTES

                                   SUGEN, Inc.

                      CONDENSED CONSOLIDATED BALANCE SHEETS
                                 (In thousands)



                                                         March 31,  December 31,
                                                           1999         1998
                                                         ---------    ---------
ASSETS                                                  (unaudited)
Current assets:
       Cash and cash equivalents                         $  37,392    $  23,901
       Short-term investments                               24,507       23,396
       Accounts receivable                                     507          373
       Prepaid expenses and other current assets             1,300        1,022
                                                         ---------    ---------
             Total current assets                           63,706       48,692


Property and equipment, net                                  7,712        7,863
Other assets                                                 3,107        2,778
                                                         ---------    ---------
                                                         $  74,525    $  59,333
                                                         =========    =========

LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
       Accounts payable                                  $   2,826    $   4,883
       Accrued liabilities                                  16,433       13,910
       Deferred contract revenue                             1,450        1,625
       Capital lease obligations - current portion           2,905        2,779
                                                         ---------    ---------
             Total current liabilities                      23,614       23,197

Long-term liabilities:
       Capital lease obligations - non-current portion       6,257        5,724
       Senior convertible notes                             31,293        5,694
                                                         ---------    ---------
             Total long-term liabilities                    37,550       11,418

Stockholders' equity:

       Common stock                                        160,609      157,171
       Deferred compensation                                  (823)        (971)
       Note receivable from stockholder                       (883)        (883)
       Accumulated deficit                                (145,542)    (130,599)
                                                         ---------    ---------
             Total stockholders' equity                     13,361       24,718
                                                         ---------    ---------
                                                         $  74,525    $  59,333
                                                         =========    =========


                             See accompanying notes.

                                        3



<PAGE>

                                   SUGEN, Inc.

                 CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                    (In thousands, except per share amounts)
                                   (unaudited)


                                                            Three Months Ended
                                                                 March 31,
                                                           ---------------------
                                                             1999        1998
                                                           --------    --------

Contract revenue (includes amounts from
   related party)                                          $  4,262    $  1,645

Costs and expenses:
    Research and development                                 16,528       9,432
    General and administrative                                2,673       1,845
                                                           --------    --------
       Total costs and expenses                              19,201      11,277
                                                           --------    --------

Operating loss                                              (14,939)     (9,632)

Other income and expenses:
    Interest income                                             521         979
    Interest expense                                           (487)       (468)
                                                           --------    --------
       Other income, net                                         34         511
                                                           --------    --------
Net loss                                                   $(14,905)   $ (9,121)
                                                           ========    ========


Basic and diluted net loss per share                       $  (0.89)   $  (0.59)
                                                           ========    ========

Shares used in computing basic and diluted net loss
  per share                                                  16,682      15,345
                                                           ========    ========

                             See accompanying notes.

                                        4

<PAGE>

<TABLE>
                                                         SUGEN, Inc.

                                       CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                      Increase (decrease) in cash and cash equivalents
                                                       (In thousands)
                                                         (unaudited)

<CAPTION>
                                                                                                             Three Months Ended
                                                                                                                 March 31,
                                                                                                      ------------------------------
                                                                                                        1999                 1998
                                                                                                      --------             --------
<S>                                                                                                   <C>                  <C>

Cash flows from operating activities
Net loss                                                                                              $(14,905)            $ (9,121)
Adjustments to reconcile net loss to net cash provided (used) by
      operating activities:
      Depreciation, amortization and other non-cash items                                                1,613                  958
        Prepaid expenses and other current assets                                                         (412)                 (98)
        Other assets                                                                                      (420)                   1
        Accounts payable                                                                                (2,057)                 536
        Accrued liabilities                                                                              2,526                  265
      Deferred revenue                                                                                    (175)                --
                                                                                                      --------             --------
Net cash used in operating activities                                                                  (13,830)              (7,459)
                                                                                                      --------             --------


Cash flows from investing activities
Sales/maturities (purchases) of short-term investments, net                                             (1,149)              (6,549)
Purchases of property and equipment, net                                                                  (459)                (454)
                                                                                                      --------             --------
Net cash used in investing activities                                                                   (1,608)              (7,003)
                                                                                                      --------             --------

Cash flows from financing activities
Proceeds from issuance of common stock, net                                                              2,162                  632
Proceeds from issuance of senior convertible notes, net                                                 26,108                 --
Proceeds from lease financing of property and equipment                                                  1,351                  856
Payments under capital lease obligations                                                                  (692)                (541)
                                                                                                      --------             --------
Net cash provided by financing activities                                                               28,929                  947
                                                                                                      --------             --------

Net increase (decrease) in cash and cash equivalents                                                    13,491              (13,515)
Cash and cash equivalents at beginning of period                                                        23,901               23,816
                                                                                                      --------             --------
Cash and cash equivalents at end of period                                                            $ 37,392             $ 10,301
                                                                                                      ========             ========

<FN>

                                                       See accompanying notes.
</FN>
</TABLE>

                                                                  5

<PAGE>

                                   SUGEN, Inc.

              NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

                                   (Unaudited)


1.       Summary of Organization and Significant Accounting Policies

         Basis of Presentation

         The accompanying  condensed  consolidated  financial statements include
         the  accounts  of  SUGEN,  Inc.  ("SUGEN"  or the  "Company")  and  its
         wholly-owned  subsidiaries.  All material intercompany transactions and
         balances  have  been   eliminated  in   consolidation.   The  condensed
         consolidated  financial  statements as of March 31, 1999, the condensed
         consolidated  statements of operations  and the condensed  consolidated
         statements  of cash flows for the three months ended March 31, 1999 and
         1998,  have been  prepared  by the Company  and are  unaudited.  In the
         opinion of management,  all necessary  adjustments  (consisting only of
         normal recurring adjustments) which the Company considers necessary for
         the fair  presentation  of the financial  position at such date and the
         operating  results and cash flows for those periods are  included.  The
         accompanying condensed consolidated financial statements should be read
         in conjunction with the financial  statements and notes thereto for the
         year ended  December 31, 1998 included in the Company's Form 10-K filed
         with the U.S.  Securities and Exchange  Commission.  The results of the
         Company's  operations  for  any  interim  period  are  not  necessarily
         indicative of the results of the Company's operations for a full fiscal
         year.

         Comprehensive Income (Loss)

         Statement  of  Financial   Accounting  Standards  No.  130,  "Reporting
         Comprehensive  Income,"  requires  companies  to report in their annual
         financial  statements  an additional  measure of income.  Comprehensive
         income (loss) includes  foreign currency  translation  gains and losses
         and  unrealized  gains and losses on equity  securities  that have been
         previously  excluded from net income and  reflected  instead in equity.
         Comprehensive  loss was not material  for the quarters  ended March 31,
         1999 and 1998.

         Derivative Financial Instruments

         Warrants  issued to purchase  convertible  debt  ("Warrant  Notes") are
         valued  up front  using  the fair  value  method  and  marked-to-market
         through  interest  expense over the remaining  warrant term, until such
         time as the warrant is exercised. Upon exercise, the difference between
         the then current  fair market  value of the warrant and the  beneficial
         conversion  feature  would be  recorded  as a premium or  discount  and
         amortized to interest  expense over the term of the Warrant Notes.  The
         derivative accounting has no impact on the Company's cash flows.

         Recent Accounting Pronouncement

         In June 1998, the Financial Accounting Standards Board issued Statement
         of Financial  Accounting  Standards No. 133, "Accounting for Derivative
         Instruments   and  Hedging   Activities."   SFAS  No.  133  establishes
         accounting and reporting standards requiring that every derivative


                                        6


<PAGE>


                                   SUGEN, Inc.

        NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (continued)

                                   (Unaudited)


Summary of Organization and Significant Accounting Policies (continued)

         instrument  be  recorded  in the  balance  sheet as  either an asset or
         liability  measured at its fair value.  It requires that changes in the
         derivative's  fair value be  recognized  currently  in earnings  unless
         specific  hedge  accounting  criteria  are met and that a company  must
         formally   document,   designate,   and  assess  the  effectiveness  of
         transactions that receive hedge  accounting.  SFAS No. 133 is effective
         for fiscal years beginning after June 15, 1999.

2.       Accrued Liabilities

         The components of accrued liabilities consist of the following:

                                                         March 31,  December 31,
                                                            1999        1998
                                                          -------      -------
                                                               (In thousands)
         Accrued research & development services          $ 9,577      $ 6,859
         Accrued compensation                               1,330        1,937
         Accrued professional fees                          1,325        1,118
         Other                                              4,201        3,996
                                                          -------      -------
                                                          $16,433      $13,910
                                                          =======      =======

3.       Research and Development Collaboration Agreements

         Laboratorios Del Dr. Esteve S.A.

         In March 1999,  the Company,  through its  affiliate,  SUGEN Europe AG,
         entered  into  an  agreement  with  Laboratorios  Del Dr.  Esteve  S.A.
         ("Esteve") to distribute,  market and sell SUGEN's  proprietary  cancer
         products  in Spain,  Portugal  and  Andorra.  In  connection  with this
         agreement, the Company recognized $1.4 million in net up-front fees and
         Esteve,  through its affiliate Laboratorios P.E.N., S.A. purchased $1.0
         million of SUGEN Common Stock at $31.50 per share.

         ASTA Medica Aktiengesellschaft

         In  March  1999,  the  Company  received  the  second  of two  $750,000
         installments  in  consideration  to extend  the  period of time for the
         screening and selection of active  compounds under the Pan-Her program;
         $375,000 was  recognized as contract  revenue for 1999 services and the
         remaining  $375,000 was in the form of the purchase of 10,964 shares of
         SUGEN Common Stock at $34.20 per share.

                                        7


<PAGE>


                                   SUGEN, Inc.

        NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (continued)

                                   (Unaudited)


4.       Senior Convertible Notes

         5% Senior Custom Convertible Notes due 2000

         For the quarter ended March 31, 1999, $537,717 of principal and accrued
         and unpaid  interest  relating to the Company's  outstanding  5% Senior
         Custom  Convertible  Notes due 2000 (the "1997  Notes") were  converted
         into  37,049  shares of Common  Stock at a  weighted  average  price of
         $14.50.  Through March 31, 1999, $12.4 million of principal and accrued
         and unpaid  interest  relating  to the 1997 Notes were  converted  into
         1,039,398  shares of Common Stock at a weighted average price of $12.07
         per share.

         12% Senior Convertible Notes due 2002

         In March 1999,  the Company  completed  the private  placement of $28.0
         million principal amount of 12% Senior  Convertible Notes due 2002 (the
         "Notes").  The Notes are convertible  into SUGEN Common Stock at $20.50
         per share.  Interest on the Notes may be paid in SUGEN  Common Stock or
         cash,  at  the  Company's  option.  As  part  of  the  Note  placement,
         purchasers  were issued  warrants (the  "Warrants") to acquire up to an
         additional  $21.0 million  principal  amount of 12% Senior  Convertible
         Notes which will mature on the third  anniversary date of issuance (the
         "Warrant  Notes").  The Warrant  Notes will have  principally  the same
         terms and  conditions as the original  Notes.  The Warrants to purchase
         the Warrant Notes are exercisable until March 2001. The Company has the
         right,  at its option,  to require the  exercise of the Warrants by the
         holders in the event that the  closing  price of the  Company's  Common
         Stock exceeds  certain levels during the term of the Warrants,  subject
         to  certain  limitations.  On  or  before  August  6,  1999,  the  then
         outstanding  balance  of the  1997  Notes  with a  floating  conversion
         mechanism will be converted into SUGEN Common Stock in accordance  with
         their  terms or, at a premium  of  approximately  125% to 132% of their
         principal amount,  exchanged for (i) an additional  principal amount of
         the 12% Senior  Convertible  Notes due 2002 (the "Exchange  Notes") and
         (ii) Warrants to acquire  Warrant Notes in a principal  amount equal to
         75% of the principal amount of the Exchange Notes.

         The estimated  fair value of the Warrants as of March 31, 1999 was $2.0
         million and is subject to quarterly adjustments for changes in the fair
         value during the period the warrants are outstanding  and  unexercised.
         The non cash fair value of the  Warrants,  together  with the costs and
         expenses  related  to  the  issuance  of  the  Notes  and  Warrants  of
         approximately  $1.9 million were  recorded as debt  issuance  costs and
         will be amortized to expense  over the term of the Notes.  Further,  if
         upon  exercise of the Warrants the fair value of the  Company's  Common
         Stock is more  than  $20.50  per  share  (the  conversion  price of the
         Warrant  Notes),  the Company may record an additional non cash expense
         for such  beneficial  conversion  feature (if such benefit  exceeds the
         previously recorded fair value of the Warrants).

                                        8


<PAGE>


                                   SUGEN, Inc.

        NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS (continued)

                                   (Unaudited)


5.       Subsequent Events

         5% Senior Custom Convertible Notes due 2000

         In April and May 1999,  $5.0  million of the 1997 Notes were  exchanged
         into 12% Senior Convertible Notes due 2002, at a premium of 125% - 132%
         of their principal amount, for approximately (i) $6.5 million principal
         amount of the Exchange Notes and (ii) $4.9 million  Warrants to acquire
         Warrant Notes.

                                        9


<PAGE>


                                   SUGEN, Inc.

Item 2.         MANAGEMENT'S DISCUSSION AND ANALYSIS
                OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

         In addition to historical  information  contained herein, the following
discussion contains words such as "intends," "believes," "anticipates," "plans,"
"expects" and similar expressions which are intended to identify forward-looking
statements  within the meaning of Section 27A of the  Securities Act of 1933, as
amended,  and Section 21E of the  Securities  Exchange Act of 1934,  as amended,
which are subject to the "safe harbor" created by those sections.  The Company's
actual  results  could  differ  materially  from the results  discussed in these
forward-looking  statements.  Factors  that could  cause or  contribute  to such
differences include the factors discussed below as well as the factors discussed
in the  Company's  Form 10-K for the year ended  December 31, 1998.  Readers are
cautioned not to place undue reliance on these forward-looking statements, which
speak only as of the date  hereof.  The  Company  undertakes  no  obligation  to
release the results of any revision to these  forward-looking  statements  which
may be made to reflect events or  circumstances  occurring after the date hereof
or to reflect the occurrence of unanticipated events.

Overview

         SUGEN was founded in July 1991 to  discover  and develop new classes of
small  molecule  drugs  which  target  specific  cellular  signal   transduction
pathways.  These  signalling  pathways  are involved in a variety of chronic and
acute  pathological  diseases,  including  cancer  and  diabetes  as  well as in
dermatologic,  ophthalmic, neurologic and immune disorders. One of the Company's
drug candidates is SU101, a PDGF TK signalling antagonist. The Company initiated
a Phase  III  clinical  trial  for use of SU101 as a  treatment  for  refractory
glioblastoma during the first quarter of 1998. Additionally, SUGEN currently has
underway  multiple Phase II studies  including SU101 in combination with BCNU in
front-line  glioma,  mono-therapy in ovarian and non-small cell lung cancers and
mono-therapy and in combination with mitozantrone in hormone refractory prostate
cancer.  A Phase  II  study of SU101 as  single  agent  therapy  for  refractory
anaplastic  astrocytoma,  another type of malignant  brain tumor,  is also being
conducted  in parallel  with the Phase III trial,  and at the same  centers.  To
date,   approximately   460  patients   have  been  treated  with  SU101  in  14
Company-sponsored   clinical   trials.   The  Company's  second  cancer  product
candidate, SU5416, is a Flk-1/KDR TK antagonist which inhibits angiogenesis (the
process by which blood vessels are formed). Currently, the Company is conducting
multiple  Phase I clinical  trials for SU5416 in solid  tumors in Europe and the
U.S.  and a Phase  I/II  study of SU5416 in  Kaposi's  sarcoma  in the U.S.  The
Company  announced  plans to  accelerate  the  development  of  SU5416  with the
initiation of Phase III clinical  trials in non-small  cell lung and  colorectal
cancers,  and for Phase  II/III  studies in  Kaposi's  sarcoma.  Meanwhile,  the
Company  will  be  working  with  certain   investigators   on  National  Cancer
Institute-sponsored Phase II and Phase I/II studies in other cancer indications.
In December 1998, the Company filed an Investigational New Drug application with
the U.S. Food and Drug  Administration  for its third cancer product,  SU6668, a
novel  broad  spectrum  inhibitor  of  angiogenesis  and  tumor  growth,  and is
currently  initiating  Phase I  clinical  trials  in Europe  and the U.S.  using
intravenous  and  oral  formulations,  respectively.  Through  March  31,  1999,
substantially  all of the Company's  revenue apart from interest income has been
earned  pursuant  to  collaborations  with  Zeneca  Limited  ("Zeneca"),   Taiho
Pharmaceutical  Ltd.  ("Taiho"),  Vision  Pharmaceuticals  L.P., an affiliate of
Allergan,  Inc.,  Allergan,  Inc.  (collectively  "Allergan"),  and ASTA  Medica
Aktiengesellschaft ("ASTA Medica").

         In June 1998, the Company  established  SUGEN  International AG ("SUGEN
International"),  as a wholly owned subsidiary. SUGEN Europe AG ("SUGEN Europe")
was  established  in  August  1998,  as  a

                                       10

<PAGE>

wholly owned subsidiary of SUGEN  International.  Both entities are incorporated
in the Canton of Schaffhausen, Switzerland. SUGEN International and SUGEN Europe
will hold certain rights to the Company's  technology portfolio outside of North
America.  The  entities  were  formed  to  facilitate  commercialization  of the
Company's products outside the United States.

         The  Company has not been  profitable  since  inception  and expects to
incur  substantial  losses  for the  foreseeable  future,  primarily  due to the
acceleration of its three cancer products in clinical development along with the
manufacturing  scale-up  and  preparation  for  potential  New Drug  Application
filings  for SU101 and SU5416 in 2000.  The  Company  expects  that  losses will
fluctuate from quarter to quarter and that such fluctuations may be substantial.
As of March 31, 1999, the Company's accumulated deficit was $145.5 million.

Results of Operations

         The  Company's  consolidated  revenues for the three months ended March
31, 1999 and 1998 were $4.3 million and $1.6 million, respectively. Revenues for
the three months ended March 31, 1999 included  contract revenue from the Taiho,
Zeneca,  Allergan and ASTA Medica collaborations.  In addition,  $1.4 million in
non-recurring  net up front fees was recognized in connection  with SUGEN Europe
establishing a marketing and  distribution  agreement with  Laboratorios Del Dr.
Esteve S.A., Spain's second largest pharmaceutical  company. These up front fees
combined with Taiho related contract funding resulted in increased  revenue over
the prior year.

         Research and development  expenses for the three months ended March 31,
1999 and 1998 were $16.5 million and $9.4 million, respectively. The increase in
spending over the same period last year was primarily due to  advancements  made
in the Company's  clinical programs,  including  additional Phase II studies and
the  progression  of the Phase III  registrational  study of SU101 and  expanded
Phase I and Phase I/II studies of SU5416.  Also  contributing to higher expenses
in 1999 was moving the Company's  third cancer  product,  SU6668,  into clinical
development and higher  personnel  related costs  accompanying the growth in the
Company's  research  and  development  programs.  The Company  expects  that its
research and  development  expenses will continue to grow in future years due to
the clinical  advancement  of SU101,  SU5416 and SU6668,  including  the related
manufacturing  and  process  development   efforts,  the  hiring  of  personnel,
additional  preclinical  studies,  the  initiation  of new  clinical  trials  on
additional drug  candidates,  and pursuant to  requirements  under the Company's
anticipated future collaborations.

         General and  administrative  expenses  for the three months ended March
31, 1999 and 1998 were $2.7 million and $1.8 million, respectively. The increase
in 1999 was  primarily  due to  higher  headcount  related  expenses  and  costs
associated with the Company's international operations. The Company expects that
its general and  administrative  expenses  will continue to increase in order to
support  the  Company's  expanding  research  and  development  efforts  and the
anticipated establishment of a sales and marketing force.

         Interest income for the three months ended March 31, 1999 and 1998 were
$521,000  and  $979,000,  respectively.  The  decrease  in 1999 was due to lower
investment  balances  resulting  from the  timing of cash flows  generated  from
financing activities. Interest expense for the three months ended March 31, 1999
and 1998 were $487,000 and $468,000,  respectively.  Increased  interest expense
associated with the Company's  capital lease  financing was partially  offset by
lower interest expense on the senior custom  convertible  notes as a significant
amount of principal has since been  converted into equity.  The Company  expects
that  interest  expense  will  continue  to  increase  in future  periods due to
interest expenses  associated with the March 1999 convertible debt financing and
continued   use  of  capital   lease   financing   for  equipment  and  facility
improvements.

                                       11

<PAGE>

Liquidity and Capital Resources

          At March  31,  1999,  the  Company  had  cash,  cash  equivalents  and
short-term   investments   of   approximately   $61.9   million   compared  with
approximately  $47.3  million at December  31,  1998.  The  increase in cash and
investments during the three months ended March 31, 1999 was due to the issuance
of the March 1999 12% senior convertible notes partially offset by the operating
expenditure for the quarter.

         Through March 31, 1999,  the Company's  principal  sources of financing
have been its initial and follow-on  public  offerings of Common Stock,  private
placements  of the Company's  Preferred and Common Stock and senior  convertible
notes,  and funds received  under the Company's  corporate  collaborations.  The
Company's   current   principal  sources  of  liquidity  are  its  research  and
development  collaborations  with Taiho,  Zeneca,  Allergan and ASTA Medica, its
cash, cash  equivalents and short-term  investments and capital lease financing.
At March 31, 1999, the Company had capital lease lines of $3.6 million available
for the purchase of equipment and facility improvements.

         The Company has entered into license and  research  agreements  whereby
the Company funds research projects performed by others or in-licenses compounds
from third  parties.  Some of the  agreements  may  require  the Company to make
milestone and royalty payments.  Under these programs,  commitments for external
research funding are approximately  $1.5 million,  $1.4 million and $1.1 million
in 1999, 2000 and 2001,  respectively.  Most of these commitments are cancelable
within a three-to-six  month period and limit the amounts payable by the Company
for  sponsored  research  under the programs  after notice of  cancelation.  The
Company  anticipates  renewing certain contracts that expired in 1997 which will
increase future  commitments  beyond the levels indicated above for 1999 through
2001.

         Net  additions of equipment and  leasehold  improvements  for the three
months ended March 31, 1999 and 1998 were $459,000 and  $454,000,  respectively.
The Company expects that its capital  additions for 1999 will be lower than that
of the prior year as 1998 included costs  associated  with the completion of the
Company's new build-to-suit  facility. In April 1999, the Company entered into a
third amendment to its facility lease agreement thereby  exercising the first of
two available expansion options. The Company's  obligations and related interest
expense will  increase in future  periods due to the exercise of this  expansion
option,  however  this is not  expected to have a financial  impact  until early
2000, the targeted completion date of the expansion.

         The Company estimates that its existing capital resources together with
facility and equipment financing,  expected revenues from current collaborations
and net  income  from  investment  activities,  will be  sufficient  to fund its
planned  operations  into  2000.  However,  there can be no  assurance  that the
underlying assumed levels of revenue and expense will prove accurate. Whether or
not these  assumptions  prove to be  accurate,  the  Company  will need to raise
substantial  additional  capital to fund its operations.  The Company intends to
seek such  additional  funding  through  collaborative  arrangements,  public or
private equity or debt financings and capital lease transactions; however, there
can be no assurance  that  additional  financing will be available on acceptable
terms, or at all. If additional  funds are raised by issuing equity  securities,
further  dilution to  stockholders  may result.  In addition,  in the event that
additional funds are obtained through arrangements with collaborative  partners,
such arrangements may require the Company to relinquish rights to certain of its
technologies,  product  candidates or products that the Company would  otherwise
seek to develop or  commercialize  itself.  If adequate funds are not available,
the Company may be required to delay,  reduce the scope of or  eliminate  one or
more of its  research  or  development  programs,  which  could  have a material
adverse effect on the Company.

                                       12

<PAGE>

Risk Factors

         The Company is at an early stage of  development  and must be evaluated
in light of the  uncertainties  and  complications  present  in a  biotechnology
company.  The Company has been in existence  only since 1991,  and to date three
cancer drug candidates (SU101, SU5416, and SU6668) have entered clinical trials.
To achieve  profitable  operations on a continuing basis, the Company,  alone or
with collaborative partners, must successfully develop,  manufacture,  introduce
and market its proposed products. Products, if any, resulting from the Company's
research and development programs are not expected to be commercially  available
for a number of years, even if they are developed  successfully and proven to be
safe and effective.  The Company has experienced  significant  operating  losses
since its inception.  The Company expects to incur significant  operating losses
at least for the next several years and expects cumulative losses to increase as
the  Company's  research and  development  efforts,  including  preclinical  and
clinical testing,  are expanded.  Substantially all of the Company's revenues to
date have been  received  pursuant to the Company's  collaborations.  Should the
Company or its collaborators fail to perform in accordance with the terms of any
of their  agreements,  any consequent loss of revenue under the agreements could
have a material adverse effect on the Company's  results of operations.  Some of
the  Company's  currently  proposed  products  are  subject to  development  and
licensing arrangements with the Company's collaborators.  Therefore, the Company
is dependent on the research and development efforts of these collaborators with
respect to some of its proposed  products  and is entitled  only to a portion of
the revenues,  if any, realized from the commercial sale of any of the potential
products covered by the collaborations in many  jurisdictions.  Before obtaining
regulatory  clearance  for  the  commercial  sale of any of its  products  under
development,  the  Company  must  demonstrate  through  preclinical  studies and
clinical  trials that the potential  product is safe and  efficacious for use in
humans for each target  indication.  The failure to adequately  demonstrate  the
safety and  efficacy  of a product  under  clinical  development  could delay or
prevent regulatory  clearance of the potential product and could have a material
adverse effect on the Company.  The foregoing  risks reflect the Company's early
stage of  development  and the nature of the  Company's  industry and  potential
products.  Also inherent at the Company's  stage of  development  are a range of
additional risks,  including  uncertainties  regarding protection of patents and
proprietary  rights,  government  regulation,   competition,   employee  issues,
manufacturing   uncertainties,   the  Company's  lack  of  sales  and  marketing
capabilities,  uncertainty of market acceptance of the Company's  products,  and
uncertainties regarding pharmaceutical pricing and reimbursement.

Year 2000

         The Year 2000 Issue is the result of information technologies, computer
systems and  scientific  and  manufacturing  equipment  being  written using two
digits  rather  than four  digits to define the  applicable  year.  As a result,
time-sensitive   functions  of  those   software   programs  and  equipment  may
misinterpret  dates after  January 1, 2000,  to refer to the  twentieth  century
rather  than the  twenty-first  century.  This could cause  system or  equipment
shutdowns,  failures or  miscalculations  resulting in  inaccuracies in computer
output or disruptions of operations,  including,  among other things, inaccurate
processing  of  financial  information  and/or  temporary  inability  to process
transactions,  manufacture  products,  or  engage  in  similar  normal  business
activities.

         The Company has a Year 2000 Project ("Y2K Project") in place to address
the  potential  exposures  related to the  impact on its  computer  systems  and
scientific and manufacturing  equipment  containing  computer related components
for the Year 2000 ("Y2K") and beyond.  Approximately  half of the  Company's Y2K
scheduled  work is complete.  The remaining work is scheduled to be completed by
the end of the fourth  quarter of 1999.  The Y2K  Project  phases  include:  (1)
inventorying  and prioritizing  business  critical  systems;  (2) Y2K compliance
analysis; (3) remediation activities including repairing or replacing identified
systems; (4) testing; and (5) developing contingency plans.

         An  inventory  of  business  critical   financial,   informational  and
operational  systems has been completed.  This inventory has been prioritized to
reflect key items of  significance.  Compliance  analysis

                                       13

<PAGE>


is approximately 70% complete for these systems.  Remediation activities vary by
department;  however, on the average,  remediation  activities are approximately
50% complete.  Testing of the Company's information technology infrastructure is
70% complete.  Testing of business critical  application  programs will begin in
the second quarter of 1999 and is scheduled to be complete by the fourth quarter
of 1999.  Contingency  planning  will begin in the second  quarter of 1999.  The
Company believes that with the completed  modifications,  the Y2K issue will not
pose  significant   operational  problems  for  its  key  computer  systems  and
equipment.  However,  if such modifications and conversions are not made, or are
not  completed  in a timely  fashion,  the Year 2000 issue could have a material
impact on the  operations of the Company,  the precise degree of which cannot be
known at this time.

         In addition to risks associated with the Company's own computer systems
and equipment,  the Company has  relationships  with, and is to varying  degrees
dependent upon, a large number of third parties that provide information,  goods
and services to the Company.  These include financial  institutions,  suppliers,
vendors and research and development associates. If significant numbers of these
third parties experience  failures in their computer systems or equipment due to
Y2K   noncompliance,   it  could  affect  the   Company's   ability  to  process
transactions,   manufacture  products  or  engage  in  similar  normal  business
activities.  While some of these risks are  outside the control of the  Company,
the Company has instituted  programs,  including internal records review and use
of external questionnaires, to identify key third parties, assess their level of
Y2K compliance, update contracts and address any noncompliance issues. The total
cost of the Y2K systems  assessments and conversions is funded through operating
cash flows and is not expected to exceed $200,000 of which approximately $50,000
has been spent to date. The actual financial impact could, however,  exceed this
estimate.

                                       14


<PAGE>


Item 3.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

         The Company is exposed to market  risk,  including  changes to interest
rates,  foreign currency exchange rates and the volatility of its stock price. A
discussion of the Company's  accounting  policies for financial  instruments and
further disclosures relating to financial instruments is included in the Summary
of Organization  and Significant  Accounting  Policies in the Notes to Condensed
Consolidated Financial Statements.

         The Company  monitors  the risks  associated  with  interest  rates and
foreign currency  exchange rate risks and has established  policies and business
practices to protect against these and other  exposures.  The Company places its
investments in instruments that meet high credit quality standards, as specified
in the Company's investment policy guidelines; the policy also limits the amount
of credit exposure to any one issue,  issuer, or type of instrument and does not
permit  derivative  financial  instruments in its investment  portfolio.  As the
result,  the  Company  does not expect  any  material  loss with  respect to its
investment portfolio.

<TABLE>
         The following table provides  information about the Company's financial
instruments  that are  sensitive to changes in interest  rates.  For  investment
securities, the table presents principal cash flows and related weighted-average
interest rates by expected maturity dates.

<CAPTION>

                                                                                                                             Fair
                                                                                                    There-                  Value At
(in millions)                          1999          2000          2001         2002      2003      after          Total    3/31/99
                                    ------------------------------------------------------------------------------------------------
<S>                                      <C>           <C>          <C>           <C>      <C>         <C>        <C>        <C>
Assets

Cash and cash equivalents                $ 37.5          --            --         --       --          --         $ 37.5     $ 37.4

 Weighted average interest rate           4.78%

Short-term investments                   $ 17.9        $  5.0       $  1.3        --       --          --         $ 24.2     $ 24.5

 Weighted average interest rate           5.40%         5.91%        5.04%

</TABLE>


         The Company's earnings are also affected by the volatility of its stock
price and  interest  rates as a result of its  issuance  of  warrants to acquire
additional 12% Senior  Convertible  Notes. The Company has attempted to mitigate
the  earnings  exposure  resulting  from these  stock  price and  interest  rate
fluctuations by establishing a ceiling on the amount of warrants exercisable per
calendar  quarter  during the first 15 months of the 2 year warrant  term.  Such
ceiling limits the amount of warrants exercisable to 33% of the then outstanding
balance.  For example, if the volatility of the Company's Common Stock increased
by 10%, the Company's  interest expense and net loss over the warrant term would
increase  by  approximately  $760,000.  Conversely,  if  the  volatility  of the
Company's Common Stock decreased by 10%, the Company's  interest expense and net
loss over the  warrant  term would  decrease  by  $700,000.  These  amounts  are
determined  by  considering  the impact of the  hypothetical  volatility  of the
Company's  Common  Stock  prices on the  estimated  fair value of the  warrants.
Although changes in the valuation of this derivative would impact earnings,  the
Company's cash flow would not be affected.


                                       15


<PAGE>


                           PART II. OTHER INFORMATION

Item 2.       CHANGES IN SECURITIES AND USE OF PROCEEDS

         On March 22, 1999,  SUGEN,  Inc. (the "Company")  announced the private
placement  of  $28,000,000   aggregate   principal  amount  of  its  12%  Senior
Convertible  Notes due 2002 (the  "Notes")  and  warrants  (the  "Warrants")  to
acquire  $21,000,000  principal  amount of 12%  Senior  Convertible  Notes  (the
"Warrant  Notes").  The private placement closed on March 24, 1999 (the "Closing
Date").  In addition,  the holders of the outstanding  balance of  approximately
$5,700,000  of the  Company's  5%  Senior  Custom  Convertible  Notes  issued in
September 1997 (the "1997 Notes") have agreed, subject to certain conditions set
forth in the  Securities  Purchase and Exchange  Agreement,  that the 1997 Notes
will be  converted  into common  stock of the Company  (the  "Common  Stock") in
accordance  with the terms of the 1997 Notes or exchanged for  additional  Notes
and Warrants at a premium of 125-132% of the outstanding principal amount of the
1997 Notes within 135 days of the Closing Date. The exchange of all  outstanding
1997 Notes would result in the issuance of an  additional  $7,368,073  principal
amount of Notes and  Warrants  to purchase an  additional  $5,526,055  principal
amount of Warrant Notes. The following summary of certain terms of the Notes and
Warrants does not purport to be a complete  description  and is qualified in its
entirety  by  reference  to  the  forms  of  Securities  Purchase  and  Exchange
Agreement,  Note and Warrant, each of which are incorporated by reference herein
and copies of which are filed as Exhibits 4.1, 4.2 and 4.3 to the Company's Form
8-K filed on March 24, 1999.

         The Notes were sold at par,  mature in March 2002 and bear  interest at
the rate of 12% per annum,  payable in cash or, at the  election of the Company,
shares of Common Stock. The principal amount of the Notes, together with accrued
and unpaid interest,  is convertible into shares of Common Stock at a conversion
price of $20.50  (the  "Conversion  Price").  Among other  covenants,  the Notes
include  covenants  that  require  the  Company  to meet  certain  cash and cash
equivalent  maintenance  requirements.  The Warrants are exercisable at any time
until March  2001,  subject to  restrictions  on the level of  exercises  in any
period as set forth in the  Warrants.  During the term of the  Warrants,  if the
closing bid price of the Company's  Common Stock exceeds 175% of the  Conversion
Price for a period of 20  consecutive  trading days, the Company may require the
Warrant holders to exercise the Warrants and purchase the Warrant Notes, subject
to  restrictions  on the level of exercises  that the Company may require in any
period as set forth in the  Warrants.  However,  if the closing bid price of the
Company's  Common Stock exceeds 200% of the Conversion  Price for a period of 20
consecutive  days,  the  Company,  without  limitation,  may require the Warrant
holders to exercise the Warrants  and  purchase the Warrant  Notes.  The Warrant
Notes will have  substantially  the same terms as the Notes with a term of three
years from  their  date of  issuance  and an  interest  rate of 12.0% per annum,
payable in cash or, at the election of the Company, shares of Common Stock.

         The Company has the right,  subject to certain  conditions set forth in
the Notes,  to redeem the Notes,  Warrants and Warrant  Notes at any one time by
delivering a cash amount equal to the outstanding principal and accrued interest
of the Notes and Warrant  Notes,  plus a premium of  105%-110%  depending on the
redemption  date, and warrants to purchase shares of the Company's  Common Stock
at the Conversion Price (the "Common Stock Warrants").


                                       16


<PAGE>


                           PART II. OTHER INFORMATION

Item 2.       CHANGES IN SECURITIES AND USE OF PROCEEDS (continued)

         The Company also has the right to defease the Notes in accordance  with
the terms set forth in the Notes.  On April 23, 1999, the Company filed with the
SEC a Registration  Statement on Form S-3 which covers the resale by the holders
of the Notes and  Warrants  issued on the Closing Date of (i) a number of shares
of Common Stock equal to at least the number of shares of Common Stock  issuable
to the holders upon  conversion  of the Notes issued on the Closing Date and the
Warrant Notes issuable upon exercise of the Warrants issued on the Closing Date,
determined as if such Notes and the Warrant  Notes,  together with three months'
accrued and unpaid  interest  thereon,  were converted in full at the Conversion
Price, and (ii) such additional  number of shares of Common Stock as the Company
in its discretion  determines to register in connection with the issuance of the
shares of Common Stock in payment of interest on the Notes issued on the Closing
Date and Warrant  Notes  issuable  upon  exercise of the Warrants  issued on the
Closing  Date and the  issuance of shares of Common  Stock upon  exercise of any
Common Stock Warrants that may be issued upon redemption of the Notes,  Warrants
and Warrant  Notes.  In the event the  registration  statement  is not  declared
effective  within 135 days of the  Closing,  at the Note  holders'  option,  the
Company will be obligated to redeem the Notes for 100% of their outstanding face
value plus accrued and unpaid interest.

         Diaz & Altschul  Capital,  LLC of New York City was the placement agent
in the transaction.  In  consideration  for its services as placement agent, the
Company paid Diaz & Altschul  Capital,  LLC a fee of $1,400,000  with respect to
the placement of the $28,000,000 principal amount of Notes issued on the Closing
Date.  Diaz & Altschul  Capital,  LLC will be entitled to additional fees in the
event the  Warrants  are  exercised.  Such sale of  securities  was exempt  from
registration  under the  Securities  Act of 1933,  as amended  (the  "Securities
Act"),  pursuant to Section 4(2)  thereof,  as a  transaction  not involving any
public offering.

         On March  31,  1999,  in  connection  with  the  existing  ASTA  Medica
collaboration,  the Company  issued and sold 10,964 shares of SUGEN Common Stock
at $34.20 per share for a total  purchase  price of $375,000  under an exemption
from registration pursuant to Section 4 (2) of the Securities Act.

         On February 16,  1999,  the Company and Esteve,  through its  affiliate
Laboratorios  P.E.N.,  S.A. entered into a Common Stock Purchase  Agreement and,
the Company  issued and sold 31,746  shares of SUGEN  Common Stock at $31.50 per
share  for a total  purchase  price  of  approximately  $1.0  million  under  an
exemption from registration pursuant to Section 4 (2) of the Securities Act.

                                       17


<PAGE>


                           PART II. OTHER INFORMATION

Item 5.       OTHER INFORMATION

                  Dr.  Heinrich  Kuhn  resigned  from  the  Company's  Board  of
              Directors effective April 22, 1999, coinciding with his retirement
              from the Max-Planck Society.

                  Effective  April 19, 1999,  the  Company's  Board of Directors
              appointed  Gerald H.  Moeller,  Ph.D.  and  Samuel A. Hamad to its
              Board of Directors.


Item 6.       EXHIBITS AND REPORTS ON FORM 8-K

(a)           Exhibits

          Exhibit Number                      Description
          --------------                      -----------

              3.1          Restated Certificate of Incorporation (2)
              3.2(ii)      Bylaws of the Registrant (1)
              3.3          Certificate   of   Designation  of  Series  A  Junior
                           Participating Preferred Stock of the Registrant (3)
             10.79         Common Stock Purchase  Agreement,  dated February 16,
                           1999, between the Registrant and Laboratorios P.E.N.,
                           S.A.
             10.80+        Second Amended and Restated  Master Lease  Agreement,
                           dated  February 26, 1999,  between the Registrant and
                           Transamerica Business Credit Corporation.
             10.81         Amended  Letter  Agreement,  dated February 22, 1999,
                           between the Registrant and Stephen Evans Freke.
             10.82         Form of Securities  Purchase and Exchange  Agreement,
                           dated  as of  March  19,  1999,  by and  between  the
                           Company and the investors named therein. (4)
             10.83         Form of 12% Senior Convertible Note due 2002. (4)
             10.84         Form of 12% Senior Convertible Note Purchase Warrant.
                           (4)

- ---------------------
             +             The Registrant has requested  confidential  treatment
                           with respect to portions of this Exhibit.

             (1)           Incorporated  by  reference to  identically  numbered
                           exhibits  filed in response to Item 16  "Exhibits" of
                           the Company's  Registration Statement on Form S-1, as
                           amended   (File   Number   33-77074),   which  became
                           effective October 4, 1994.

                                       18


<PAGE>


                           PART II. OTHER INFORMATION


Item 6.       EXHIBITS AND REPORTS ON FORM 8-K (continued)

             (2)           Incorporated  by  reference to  identically  numbered
                           exhibits  filed in response to Item 14  "Exhibits" of
                           the Company's Annual Report of Form 10-K for the year
                           ended December 31, 1994.
             (3)           Filed as an  exhibit to the Form 8-K  Current  Report
                           dated  July  26,  1995  and  incorporated  herein  by
                           reference.
             (4)           Filed as an  exhibit to the Form 8-K  Current  Report
                           dated  March  24,  1999 and  incorporated  herein  by
                           reference.


(b)           Reports on Form 8-K

              SUGEN,  Inc.  filed a Current  Report on Form 8-K, dated March 24,
              1999,  in  connection  with the private  placement of  $28,000,000
              aggregate principal amount of its 12% Senior Convertible Notes due
              2002.

                                       19


<PAGE>



                                   SIGNATURES


Pursuant to the  requirements  of the  Securities  and Exchange Act of 1934, the
Registrant has duly caused this amended report to be signed on its behalf by the
undersigned thereunto duly authorized.


Date:    May 28, 1999                          SUGEN, Inc.
         ----------------------------





By:    /s/ Stephen Evans-Freke                 By:   /s/ James L. Knighton
       -------------------------------               ---------------------------
       Stephen Evans-Freke                           James L. Knighton
       Chairman of the Board and                     Senior Vice President and
       Principal Executive Officer                   Principal Financial Officer

                                       20


<PAGE>


                                   SUGEN, Inc.

                                  EXHIBIT INDEX


          Exhibit Number                      Description
          --------------                      -----------

              3.1          Restated Certificate of Incorporation (2)
              3.2(ii)      Bylaws of the Registrant (1)
              3.3          Certificate   of   Designation  of  Series  A  Junior
                           Participating Preferred Stock of the Registrant (3)
             10.79         Common Stock Purchase  Agreement,  dated February 16,
                           1999, between the Registrant and Laboratorios P.E.N.,
                           S.A.
             10.80+        Second Amended and Restated  Master Lease  Agreement,
                           dated  February 26, 1999,  between the Registrant and
                           Transamerica Business Credit Corporation.
             10.81         Amended Letter  Agreement,  dated  February  22,1999,
                           between the Registrant and Stephen Evans Freke.
             10.82         Form of Securities  Purchase and Exchange  Agreement,
                           dated  as of  March  19,  1999,  by and  between  the
                           Company and the investors named therein. (4)
             10.83         Form of 12% Senior Convertible Note due 2002. (4)
             10.84         Form of 12% Senior Convertible Note Purchase Warrant.
                           (4)
             27            Financial Data Schedule

- ---------------------
             +             The Registrant has requested  confidential  treatment
                           with respect to portions of this Exhibit.

             (1)           Incorporated  by  reference to  identically  numbered
                           exhibits  filed in response to Item 16  "Exhibits" of
                           the Company's  Registration Statement on Form S-1, as
                           amended   (File   Number   33-77074),   which  became
                           effective October 4, 1994.

             (2)           Incorporated  by  reference to  identically  numbered
                           exhibits  filed in response to Item 14  "Exhibits" of
                           the Company's Annual Report of Form 10-K for the year
                           ended December 31, 1994.

             (3)           Filed as an  exhibit to the Form 8-K  Current  Report
                           dated  July  26,  1995  and  incorporated  herein  by
                           reference.

             (4)           Filed as an  exhibit to the Form 8-K  Current  Report
                           dated  March  24,  1999 and  incorporated  herein  by
                           reference.




                                       21



                                                                   EXHIBIT 10.79
                                    AGREEMENT

                       FOR THE PURCHASE OF COMMON STOCK OF

                                   SUGEN, INC.

                                       BY

                            LABORATORIOS P.E.N., S.A.


<PAGE>
<TABLE>

                                                    TABLE OF CONTENTS

<CAPTION>
                                                                                                               Page
                                                                                                               ----

<S>      <C>                                                                                                      <C>
1.       PURCHASE AND SALE OF COMMON STOCK........................................................................2

         1.1      Issue of Common Stock...........................................................................2

2.       CLOSING DATE; DELIVERY...................................................................................2

         2.1      Closing.........................................................................................2

         2.2      Payment and Delivery............................................................................2

3.       REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE COMPANY.................................................3

         3.1      Organization....................................................................................3

         3.2      Authority.......................................................................................3

         3.3      Issuance of the Shares..........................................................................3

         3.4      Registration Rights Covenant....................................................................3

4.       REPRESENTATIONS, WARRANTIES AND COVENANTS OF PURCHASER...................................................6

         4.1      Legal Power.....................................................................................6

         4.2      Due Execution...................................................................................6

         4.3      Investment Representations and Covenants........................................................6

         4.4      Standstill Covenant.............................................................................8

         4.5      Lockup Covenant.................................................................................8

5.       CONDITIONS TO CLOSING....................................................................................8

         5.1      Conditions to Obligations of Purchaser..........................................................8

         5.2      Conditions to Obligations of the Company........................................................9

6.       MISCELLANEOUS............................................................................................9

         6.1      Governing Law...................................................................................9

         6.2      Successors and Assigns..........................................................................9

         6.3      Entire Agreement................................................................................9

         6.4      Separability...................................................................................10

         6.5      Amendment and Waiver...........................................................................10

         6.6      Notices........................................................................................10

         6.7      Fees and Expenses..............................................................................10

         6.8      Titles and Subtitles...........................................................................10

         6.9      Counterparts...................................................................................10

         6.10     Consent to Jurisdiction and Venue..............................................................10

</TABLE>

<PAGE>


                         COMMON STOCK PURCHASE AGREEMENT


         THIS COMMON STOCK PURCHASE  AGREEMENT  (the  "Agreement") is made as of
February 16, 1999 (the "Effective Date"), by and between SUGEN, INC., a Delaware
corporation (the "Company"),  and LABORATORIOS  P.E.N.,  S.A., a Spanish company
("Purchaser").  In  consideration  of  the  mutual  promises,   representations,
warranties and conditions set forth in this Agreement, the Company and Purchaser
agree as follows:

1. PURCHASE AND SALE OF COMMON STOCK.

     1.1      Issue of Common Stock.

          (a) The  Company has  authorized  the  issuance  and sale of up to the
aggregate  number of shares of its common  stock,  $.01 par value  (the  "Common
Stock"), as set forth in Section 2.1 hereof (the "Shares").

          (b)  In  reliance  upon  Purchaser's  representations  and  warranties
contained in Section 4 hereof and subject to the terms and  conditions set forth
herein,  the Company  agrees to sell to Purchaser  the Shares,  to be issued and
sold at a price per share equal to two hundred percent (200%) of the Fair Market
Value thereof. For purposes of this Agreement, Fair Market Value shall equal the
closing  sales  price of a share of  Common  Stock as  reported  for the  Nasdaq
National Market on the last trading day preceding the Effective Date.

          (c) In reliance upon the representations and warranties of the Company
contained in Section 3 hereof and subject to the terms and  conditions set forth
herein, Purchaser hereby agrees to purchase the Shares at the per share purchase
price set forth above.

2. CLOSING DATE; DELIVERY.

     2.1 Closing.  The closing of the sale and purchase of the Shares under this
Agreement (the "Closing"), having a value of approximately $1,000,000 based on a
price per share equal to two  hundred  percent  (200%) of the Fair Market  Value
thereof,  shall be held on or about  10:00 a.m.  (Pacific  Standard  Time) on or
about February 16, 1999 (the "Closing  Date"),  at the offices of Cooley Godward
LLP, Five Palo Alto Square, 3000 El Camino Real, Palo Alto, California 94306, or
at such other time and place as the  Company  and  Purchaser  may agree.  At the
Closing,  the Company will issue and sell,  and  Purchaser  will  purchase,  the
Shares for an aggregate purchase price of approximately $1,000,000.

     2.2  Payment  and  Delivery.  At the  Closing,  subject  to the  terms  and
conditions  hereof,  the Company will deliver to Purchaser a stock  certificate,
registered in the name of Purchaser,  representing the Shares to be purchased by
Purchaser  from the  Company,  dated as of the Closing,  against  payment of the
purchase price  therefor by wire  transfer,  unless other means of payment shall
have been agreed upon by Purchaser and the Company.

                                       2

<PAGE>

3. REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE COMPANY.

         The Company  hereby  represents  and  warrants to  Purchaser  as of the
Closing Date as follows:

     3.1 Organization. The Company is a corporation, duly incorporated,  validly
existing  and in  good  standing  under  the  laws  of the  jurisdiction  of its
incorporation.

     3.2 Authority.  The Company has all requisite  power and authority to enter
into this Agreement, and to consummate the transactions contemplated hereby. The
execution  and  delivery  of  this  Agreement  and  the   consummation   of  the
transactions  contemplated  hereby have been duly  authorized  by all  necessary
corporate action on the part of the Company,  and upon execution and delivery by
the Company,  this Agreement will  constitute a valid and binding  obligation of
the  Company,  enforceable  against  the Company in  accordance  with its terms,
subject to applicable  bankruptcy,  insolvency,  reorganization,  moratorium and
similar  laws  relating to or affecting  creditor's  rights from time to time in
effect, and subject to general equity principles.

     3.3 Issuance of the Shares.  The Shares,  when issued pursuant to the terms
of this Agreement,  will be duly and validly  authorized and issued,  fully paid
and nonassessable.

     3.4 Registration Rights Covenant.

          (a) In the event  that the term of the Letter  Agreement,  dated as of
January 18, 1999 and signed by  Purchaser  on January 26,  1999,  by and between
Purchaser  and SUGEN Europe AG (the "Letter  Agreement"),  terminates or expires
and is not extended, and a definitive Distribution Agreement is not entered into
by the  parties  pursuant  to the terms of, and as  contemplated  by, the Letter
Agreement,  at any time  during  the 90-day  period  immediately  following  the
termination  or expiration  of the Letter  Agreement,  Purchaser  shall have the
right to cause the Company to file a registration statement under the Securities
Act of 1933, as amended (the "Securities Act") for a public offering of all, but
not part, of the Shares  beneficially  owned by Purchaser by delivering  written
notice  thereof  to the  Company  specifying  that all of the  Shares  are to be
included in such  registration  and the intended method of distribution  thereof
(the  "Registration  Request").  Upon receipt of the Registration  Request,  the
Company shall, as  expeditiously  as possible,  use its best efforts to promptly
effect the  registration  under the  Securities  Act, and all  applicable  state
securities laws, to the extent necessary to permit the sale or other disposition
by Purchaser of the Shares to be so registered in accordance with such notice.

          (b) The demand  registration  rights  granted  in  Section  3.4(a) are
subject to the following limitations:  (i) the Company shall not be obligated to
effect more than one registration  pursuant to Section 3.4(a),  (ii) the Company
shall not be  obligated  to  effect  such  registration  for a period of 60 days
following the closing of an underwritten public offering of the Company's equity
securities  that  is  in  registration  at  the  time  of  the  receipt  of  the
Registration Request (provided that the period within which Purchaser may demand
registration  hereunder  will be  extended  by the  number  of days by which the
registration  requested by Purchaser is delayed pursuant to this sentence);  and
(iii) if the Company  shall  furnish to  Purchaser a  certificate  signed

                                       3

<PAGE>

by the  Chairman of the Board of  Directors  of the Company  stating that in the
good  faith  judgment  of the Board of  Directors  of the  Company,  it would be
seriously  detrimental to the Company and its stockholders for such registration
to be effected at such time,  then the Company shall have the right to defer the
filing of the  registration for a period of not more than 180 days after receipt
of the Registration Request (provided that the period within which Purchaser may
demand  registration  hereunder  will be extended by the number of days by which
the registration requested by Purchaser is delayed pursuant to this sentence).

          (c) If and when the Company is required by the  provisions  of Section
3.4(a) to  include  the  Shares in a  registration  under  the  Securities  Act,
Purchaser will furnish in writing such information as is reasonably requested by
the  Company  for  inclusion  in the  registration  statement  relating  to such
offering  and such other  information  and  documentation  as the Company  shall
reasonably request, and the Company will, as expeditiously as possible:

               (i) Prepare and file with the Securities and Exchange  Commission
("SEC") a  registration  statement  with respect to such  securities and use its
best efforts to cause such  registration to become and remain effective for such
period as may be necessary to permit the successful marketing of such securities
but not exceeding 120 days (excluding any period during which a stop order is in
effect).

               (ii)  Prepare  and  file  with  the  SEC  such   amendments   and
supplements to such registration statement and the prospectus used in connection
therewith as may be necessary to comply with the  provisions  of the  Securities
Act and to keep such  registration  statement  effective for that period of time
specified in paragraph (i) of this section.

               (iii)  Furnish  to  Purchaser  such  number of  prospectuses  and
preliminary  prospectuses in conformity with the  requirements of the Securities
Act, and such other documents as such Purchaser may reasonably  request in order
to  facilitate  the public sale or other  disposition  of the Shares  registered
hereunder.

               (iv) Use its best  efforts  to  register  or  qualify  the Shares
covered by such  registration  statement under such other securities or blue sky
laws of such  jurisdictions as Purchaser shall reasonably request and do any and
all  other  acts and  things  which  may be  necessary  or  desirable  to enable
Purchaser  to  consummate   the  public  sale  or  other   disposition  in  such
jurisdictions  of the Shares covered by such  registration  statement,  provided
that the Company shall not be required in connection therewith or as a condition
thereto  to qualify to do  business  or to file a general  consent to service of
process in any such states or jurisdictions.

          (d) In the  event of a  registration  of any of the  Shares  under the
Securities  Act pursuant to Section  3.4(a) in connection  with an  underwritten
public offering,  the Company will enter into and perform its obligations  under
an  underwriting  agreement,  in usual and  customary  form,  with the  managing
underwriters of such offering,  including without limitation providing usual and
customary  indemnification.  In the event  Purchaser  proposes to sell Shares in
accordance with this Section pursuant to an underwritten  offering,  the Company
shall have the right to approve the  managing  underwriters  for such  offering;
provided,  however,  that  such  approval  shall not be  unreasonably  withheld.
Purchaser will also provide usual and customary  indemnification  to the Company
and its affiliates with respect to claims,  losses and damages



                                       4
<PAGE>

arising out of or based on any untrue statement (or alleged untrue statement) of
a material fact  contained in any  registration  statement,  prospectus or other
document, or any omission (or alleged omission) to state therein a material fact
required to be stated  therein or necessary to make the  statements  therein not
misleading;  provided,  however, that in no event shall any indemnity under this
Section  3.4(d)  exceed  the  gross  proceeds  from  the  offering  received  by
Purchaser.

          (e) At any time during the period set forth in Section 3.4(a),  if the
Company  shall  determine to register any of its  securities  either for its own
account  or the  account  of a  security  holder  or  holders  exercising  their
respective  demand  registration  rights (other than pursuant to Section  3.4(a)
hereof), other than a registration relating solely to employee benefit plans, or
a registration  relating solely to a Rule 145 transaction,  or a registration on
any registration  form that does not permit  secondary  sales,  then the Company
will:

               (i) promptly give to Purchaser a written notice thereof; and

               (ii) use its best  efforts to include in such  registration  (and
any related  qualification  under blue sky laws or other compliance),  except as
set forth in Section 3.4(f) below, and in any underwriting involved therein, all
the Shares  specified in a written  request or requests  made by  Purchaser  and
received by the Company  within  twenty (20) days after the written  notice from
the Company described in clause (i) above is mailed or delivered by the Company.
Such written request may specify all or a part of the Shares.

          (f) If the registration of which the Company gives notice to Purchaser
is for a registered public offering involving an underwriting, the Company shall
so advise  Purchaser as a part of the written  notice given  pursuant to Section
3.4(e)(i).  In such event,  the right of Purchaser to  registration  pursuant to
Section  3.4(e) shall be  conditioned  upon  Purchaser's  participation  in such
underwriting and the inclusion of Purchaser's  Shares in the underwriting to the
extent provided herein. Purchaser shall (together with the Company and the other
holders of securities  of the Company with  registration  rights to  participate
therein  distributing their securities through such underwriting)  enter into an
underwriting  agreement  in  customary  form  with  the  representative  of  the
underwriter or underwriters selected by the Company.

         Notwithstanding  any other  provision of Sections 3.4(e) or (f), if the
representative of the underwriters advises the Company in writing that marketing
factors  require a limitation  on the number of shares to be  underwritten,  the
representative  may (subject to the  limitations  set forth  below)  exclude all
Shares from,  or limit the number of Shares to be included in, the  registration
and  underwriting.  The Company  shall so advise  Purchaser and other holders of
securities requesting  registration,  and the number of shares that are entitled
to be included in the registration and underwriting  shall be allocated first to
the Company for  securities  being sold for its own account and  thereafter  the
number of shares that are entitled to be included in the  registration  shall be
allocated among Purchaser and other holders requesting  inclusion of shares on a
pro rata basis,  subject to any prior agreements among the Company and its other
stockholders,  but only to the extent  that such other  agreements  provide  for
additional  limitations on the number of shares such other  stockholders  or the
Company will be entitled to include in the registration, which agreements are in
effect as of the Effective Date. If Purchaser or any other person does not agree
to the terms of any such underwriting, Purchaser and any other such



                                       5
<PAGE>

person  shall be excluded  therefrom  by written  notice from the Company or the
underwriter.  Any Shares or other  securities  excluded or  withdrawn  from such
underwriting shall also be withdrawn from such registration.

          (g) As used herein,  "Registration  Expenses"  shall mean all expenses
incurred by the Company in complying with this Section 3.4,  including,  without
limitation, all registration,  qualification and filing fees; printing expenses;
fees  and   disbursements   of  counsel  for  the  Company  (and  the  fees  and
disbursements  of  counsel  for the  Company in its  capacity  as counsel to the
Purchaser hereunder;  if Company counsel does not make itself available for this
purpose,  the Company  will pay the  reasonable  fees and  disbursements  of one
counsel  for the  Purchaser  as  selected  by  Purchaser)  and of the  Company's
independent accounting firm; blue sky fees and expenses;  underwriting discounts
and commissions and the expense of any special audits incident to or required by
any such  registration  (but excluding the compensation of regular  employees of
the Company which shall be paid in any event by the Company). Purchaser will pay
all Registration  Expenses in connection with a registration pursuant to Section
3.4(a) hereof;  provided,  however,  that in the event of a registration  of the
Shares  pursuant  to Section  3.4(a)  either as a result of  termination  of the
Letter  Agreement by SUGEN Europe AG, or if Purchaser  withdraws  its demand for
registration after having learned of a material adverse change in the condition,
business,  or  prospects of the Company from that known to Purchaser at the time
of its demand (in which  case  Purchaser  shall  retain its rights  pursuant  to
Section 3.4(a)),  all Registration  Expenses shall be borne by the Company.  All
Registration  Expenses in connection with any  registration  pursuant to Section
3.4(e)  hereof  shall be  borne  by the  Company;  provided,  however,  that any
incremental  expenses  incurred by the Company  solely by reason of  Purchaser's
exercise of registration rights pursuant to Section 3.4(e) shall be borne by the
Purchaser.

          (h) The rights  conferred upon Purchaser under this Section 3.4 may be
assigned by Purchaser to any permitted  transferee of the Shares,  provided that
each such transfer  complies with Section 4.5 and provided,  further,  that only
Purchaser  shall be  authorized to give notice to the Company of any request for
registration  under this Section 3.4(a) and only Purchaser  shall be entitled to
receive notice pursuant to Section 3.4 (a) hereof.

4. REPRESENTATIONS, WARRANTIES AND COVENANTS OF PURCHASER.

         Purchaser hereby represents, warrants and covenants with the Company as
follows:

     4.1  Legal  Power.  Purchaser  has the  requisite  corporate  power  and is
authorized to enter into this Agreement, to purchase the Shares hereunder and to
carry out and perform its obligations under the terms of this Agreement.

     4.2 Due  Execution.  This Agreement has been duly  authorized  executed and
delivered by Purchaser, and upon due execution and delivery by the Company, this
Agreement will be a valid and binding agreement of Purchaser.

     4.3 Investment  Representations  and Covenants.  Purchaser is acquiring the
Shares for its own account, not as nominee or agent, for investment and not with
a view to or for resale in connection  with, any distribution or public offering
thereof within the meaning of the



                                       6
<PAGE>

Securities Act.  Purchaser  understands that the Shares have not been registered
under the  Securities  Act, but are instead  being offered and sold to Purchaser
pursuant to an exemption from registration contained in the Securities Act based
in part upon the following representations and warranties:

     (a)  Purchaser  is  capable  of  evaluating  the  merits  and  risks of its
investment  in the  Company and has the  capacity to protect its own  interests.
Purchaser must bear the economic risk of this  investment  unless the Shares are
registered  pursuant to the Securities Act, or an exemption from registration is
available.  Purchaser  understands that the Company has no present  intention of
registering the Shares.  Purchaser also  understands  that there is no assurance
that any exemption from registration  under the Securities Act will be available
and that,  even if available,  such  exemption  may not allow such  Purchaser to
transfer  all or any  portion  of the  Shares  under the  circumstances,  in the
amounts or at the times Purchaser might propose.

     (b) Purchaser is acquiring the Shares for such  Purchaser's own account for
investment only, and not with a view towards their distribution.

     (c)  Purchaser  represents  that by reason of its, or of its  management's,
business or financial experience,  Purchaser has the capacity to protect its own
interests in connection with the transactions contemplated in this Agreement.

     (d) Purchaser  has had an  opportunity  to discuss the Company's  business,
management and financial affairs with directors,  officers and management of the
Company  and has had the  opportunity  to review the  Company's  operations  and
facilities.  Purchaser  has also had the  opportunity  to ask  questions  of and
receive  answers from,  the Company and its  management  regarding the terms and
conditions of this investment.

     (e)  Purchaser  acknowledges  and  agrees  that  the  Shares  must  be held
indefinitely unless they are subsequently registered under the Securities Act or
an exemption from such registration is available.  Purchaser has been advised or
is aware of the provisions of Rule 144  promulgated  under the  Securities  Act,
which permits limited resale of shares purchased in a private  placement subject
to the satisfaction of certain  conditions,  including,  among other things: the
availability of certain current public information about the Company, the resale
occurring  not less than two years after a party has  purchased and paid for the
security  to  be  sold,  the  sale  being  through  an   unsolicited   "broker's
transaction"  or in  transactions  directly with a market maker (as said term is
defined under the  Securities  Exchange Act of 1934,  as amended (the  "Exchange
Act")) and the number of shares  being sold  during any  three-month  period not
exceeding specified limitations.  Each certificate  representing Shares shall be
stamped  or  otherwise  imprinted  with a legend  substantially  similar  to the
following:

         THE SECURITIES  REPRESENTED  HEREBY HAVE NOT BEEN REGISTERED  UNDER THE
         SECURITIES  ACT OF 1933 (THE  "ACT")  AND MAY NOT BE  OFFERED,  SOLD OR
         OTHERWISE  TRANSFERRED,  ASSIGNED,  PLEDGED OR HYPOTHECATED  UNLESS AND
         UNTIL THEY ARE  REGISTERED  UNDER THE ACT OR UNLESS (A) THE COMPANY HAS
         RECEIVED  AN OPINION OF COUNSEL  SATISFACTORY  TO THE  COMPANY  AND ITS


                                       7
<PAGE>

         COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED OR (B) SUCH SALE IS MADE
         PURSUANT TO RULE 144 UNDER THE ACT.

     4.4 Standstill Covenant. Purchaser agrees that neither Purchaser nor any of
its  affiliates  will in any manner,  directly or indirectly  (i) effect,  seek,
offer or propose to effect any  acquisition  of any  securities or assets of the
Company,   any  tender  or  exchange  offer,   merger,   business   combination,
recapitalization or other extraordinary transaction involving the Company or any
solicitation  of  proxies  or  consents  to vote any  voting  securities  of the
Company,  (ii) form,  join or in any way participate in a "group" (as defined in
the Exchange Act) with respect to any voting  securities  of the Company,  (iii)
solicit or participate in any  solicitation of proxies  relating to the election
of  directors of the Company,  or (iv) enter into any  agreement  with any other
person with  respect to the  foregoing,  or assist any other person to do any of
the foregoing; provided that (A) Purchaser may purchase additional securities in
an  amount  sufficient  to  allow  Purchaser  to own  up to  4.9%  of  the  then
outstanding  shares of Common Stock of the Company  (excluding any shares issued
directly to Purchaser or its  Affiliates  by the  Company);  (B) the transfer of
Shares in accordance  with Section 4.5 and the voting  thereof by the transferee
shall not be deemed a prohibited group formation or proxy solicitation; (C) this
sentence  shall not  prohibit  the  acquisition  or  disposition  of shares  for
investment  purposes  only in the open  market  in the  ordinary  course  by any
pension  fund  or  trust  for the  benefit  of  employees  of  Purchaser  or its
affiliates;  and  (D) in the  event  that  the  term  of  the  Letter  Agreement
terminates  or  expires  and  is not  extended,  and a  definitive  Distribution
Agreement  is not entered  into by the parties  pursuant to the terms of, and as
contemplated  by,  the  Letter  Agreement,  the  restrictions  set forth in this
Section  4.4  shall  terminate  and  have  no  force  or  effect  following  the
termination or expiration of the Letter Agreement.

     4.5 Lockup  Covenant.  Purchaser  agrees that for three years from the date
hereof,  Purchaser will not,  without the prior written approval of the Company,
offer, sell or otherwise  dispose of, directly or indirectly,  any capital stock
of the Company which  Purchaser may own  directly,  indirectly or  beneficially;
provided  that  (i)  Purchaser  may  transfer  some  or all of the  Shares  to a
corporation,  partnership  or other legal entity of which  Purchaser  has actual
control or is controlled by or under common control with Purchaser,  but only if
such  transferee  agrees in  writing to hold such  Shares  subject to all of the
provisions  of this  Agreement  and to transfer such Shares to Purchaser if such
transferee  ceases to be controlled by Purchaser (all such Shares so transferred
shall be deemed to be shares held by Purchaser for all purposes hereunder), (ii)
the restrictions  contained in this sentence shall terminate  automatically upon
the  acquisition by any person or group (as defined in the Exchange Act),  other
than Purchaser and its affiliates,  of more than 21% of the  outstanding  voting
securities  of  the  Company,   (iii)  this  sentence  shall  not  prohibit  the
acquisition or  disposition  of shares for investment  purposes only in the open
market in the  ordinary  course by any pension  fund or trust for the benefit of
employees of Purchaser or its affiliates, and (iv) in the event that the term of
the Letter Agreement terminates or expires and is not extended, and a definitive
Distribution  Agreement is not entered into by the parties pursuant to the terms
of, and as contemplated by, the Letter Agreement,  the restrictions set forth in
this  Section  4.5 shall  terminate  and have no force or effect  following  the
termination or expiration of the Letter Agreement.



                                       8
<PAGE>

5. CONDITIONS TO CLOSING.

     5.1  Conditions  to  Obligations  of Purchaser.  Purchaser's  obligation to
purchase the Shares at the Closing is subject to the fulfillment, at or prior to
the Closing, of all of the following conditions:

          (a) Representations  and Warranties True;  Performance of Obligations.
The representations and warranties made by the Company in Section 3 hereof shall
be true and correct in all  material  respects on the Closing Date with the same
force and  effect as if they had been made on and as of said date.  The  Company
shall have  performed  all  obligations  and  conditions  herein  required to be
performed by it on or prior to the Closing Date.

          (b) Proceedings and Documents.  All corporate and other proceedings in
connection  with the  transactions  contemplated  at the Closing  hereby and all
documents  and  instruments  incident to such  transactions  shall be reasonably
satisfactory in substance and form to Purchaser.

     5.2 Conditions to Obligations of the Company.  The Company's  obligation to
issue and sell the Shares at the Closing is subject to the  fulfillment,  to the
Company's satisfaction, on or prior to the Closing, of the following conditions:

          (a)  Representations  and  Warranties  True. The  representations  and
warranties  made by  Purchaser  in Section 4 hereof shall be true and correct at
the Closing  Date with the same force and effect as if they had been made on and
as of the date of the Closing Date.

          (b)  Performance of  Obligations.  Purchaser  shall have performed and
complied with all agreements and conditions  herein  required to be performed or
complied  with by them on or before the Closing Date,  and Purchaser  shall have
delivered payment to the Company in respect of its purchase of Shares.

          (c) Qualifications,  Legal Investment. All authorizations,  approvals,
or permits,  if any, of any  governmental  authority or  regulatory  body of the
United  States or of any state that are required in  connection  with the lawful
sale and issuance of the Shares at the Closing  pursuant to this Agreement shall
have been duly obtained and shall be effective on and as of the Closing Date. No
stop  order or other  order  enjoining  the sale of the  Shares  shall have been
issued and no proceedings for such purpose shall be pending or, to the knowledge
of the Company,  threatened by the SEC or any  commissioner  of  corporations or
similar officer of any state having  jurisdiction over this transaction.  At the
time of the Closing,  the sale and  issuance of the Shares to be  purchased  and
sold at the Closing shall be legally  permitted by all laws and  regulations  to
which Purchaser and the Company are subject.

6. MISCELLANEOUS.

     6.1 Governing Law. This Agreement  shall be governed by and construed under
the laws of the State of California as applied to  agreements  among  California
residents,  made and to be performed  entirely  within the State of  California,
without regard to principles of conflict of laws.

                                       9
<PAGE>

     6.2 Successors and Assigns.  Except as otherwise expressly provided herein,
the  provisions  hereof shall inure to the benefit of, and be binding upon,  the
successors, assigns, heirs, executors, and administrators of the parties hereto.

     6.3 Entire Agreement. This Agreement and the Exhibits hereto, and the other
documents   delivered   pursuant   hereto,   constitute   the  full  and  entire
understanding and agreement among the parties with regard to the subjects hereof
and no party  shall be liable or bound to any other  party in any  manner by any
representations, warranties, covenants, or agreements except as specifically set
forth  herein or therein.  Nothing in this  Agreement,  express or  implied,  is
intended  to confer  upon any  party,  other than the  parties  hereto and their
respective  successors  and  assigns,  any  rights,  remedies,  obligations,  or
liabilities under or by reason of this Agreement,  except as expressly  provided
herein.

     6.4 Separability. In case any provision of this Agreement shall be invalid,
illegal, or unenforceable, it shall to the extent practicable, be modified so as
to make it valid,  legal and  enforceable and to retain as nearly as practicable
the intent of the parties, and the validity, legality, and enforceability of the
remaining provisions shall not in any way be affected or impaired thereby.

     6.5 Amendment and Waiver.  Except as otherwise provided herein, any term of
this Agreement may be amended,  and the observance of any term of this Agreement
may  be  waived  (either   generally  or  in  a  particular   instance,   either
retroactively  or  prospectively,  and either for a specified  period of time or
indefinitely),  with the  written  consent of the  Company  and  Purchaser.  Any
amendment or waiver  effected in  accordance  with this section shall be binding
upon any  holder of any  security  purchased  under  this  Agreement  (including
securities into which such securities have been  converted),  each future holder
of all such securities, and the Company.

     6.6  Notices.  All notices and other  communications  required or permitted
hereunder  shall be in  writing  and  shall be  deemed  effectively  given  upon
personal  delivery,  on the first  business day  following  mailing by overnight
courier,  or on the fifth day following mailing by registered or certified mail,
return  receipt  requested,  postage  prepaid,  addressed  to  the  Company  and
Purchaser at the addresses included herein.

     6.7 Fees and  Expenses.  The  Company  and  Purchaser  shall bear their own
expenses  and legal fees with  respect to this  Agreement  and the  transactions
contemplated hereby.

     6.8 Titles and Subtitles. The titles of the paragraphs and subparagraphs of
this  Agreement  are  for  convenience  of  reference  only  and  are  not to be
considered in construing this Agreement.

     6.9  Counterparts.  This  Agreement  may  be  executed  in  any  number  of
counterparts,  each of  which  shall be  deemed  an  original,  but all of which
together shall constitute one instrument.

     6.10 Consent to Jurisdiction  and Venue.  Any claim or controversy  arising
out of or related to this Agreement or any breach hereof shall be submitted to a
court of  applicable  jurisdiction  in the State of  California  and each  party
hereby consents to the jurisdiction and venue of such court.

                                       10
<PAGE>

         IN WITNESS WHEREOF,  the parties hereto have executed this Common Stock
Purchase Agreement as of the date set forth in the first paragraph hereof.

                                     SUGEN, INC.



                                    By: /s/ James L. Knighton
                                       -----------------------------------------
                                       James L. Knighton
                                       Senior Vice President and Chief Financial
                                       Officer


                                     LABORATORIOS P.E.N.,  S.A.



                                    By: /s/ Juan Andreu
                                       -----------------------------------------
                                       Name: Juan Andreu
                                       Title: General Manager



                                       11

                                                                   EXHIBIT 10.80

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                            UNDER 17 C.F.R. SS.SS. 200.80(B)(4),
                                                            200.83 AND 240.24B-2

                                                            Customer Number 1036

                           SECOND AMENDED AND RESTATED
                             MASTER LEASE AGREEMENT


Lessor:           TRANSAMERICA BUSINESS CREDIT CORPORATION
                  Riverway II
                  West Office Tower
                  9399 West Higgins Road
                  Rosemont, Illinois  60018


Lessee:           SUGEN, INC.
                  230 East Grand Avenue
                  South San Francisco, CA  94080-4811

This Second Amended and Restated Master Lease Agreement  ("Agreement")  dated as
of February 26, 1999 amends and restates a Master Lease Agreement ("Master Lease
Agreement")  dated March 28, 1997 and an Amended and  Restated  Lease  Agreement
("Amended  and  Restated  Lease")  dated as of November  12,  1997,  all between
Transamerica Business Credit Corporation  ("Lessor") and Sugen, Inc. ("Lessee").
Except as amended and restated by this Agreement,  the Master Lease Agreement as
amended by the Amended and Restated Lease and all other  documents and schedules
executed by Lessee in connection  with the Master Lease  Agreement,  the Amended
and Restated Lease and this Agreement are ratified and confirmed in all respects
and  shall  remain in full  force and  effect.  Upon the  effectiveness  of this
Agreement,  all references in any of the lease  documents  executed by Lessee in
connection  with the Master Lease  Agreement,  the Amended and Restated Lease to
the "Master Lease  Agreement",  "Master  Lease",  "this  Agreement",  or similar
terms,  shall  mean and refer to the  Master  Lease  Agreement  as  amended  and
restated by this Agreement.  The execution,  delivery and  effectiveness of this
Agreement  shall  not,  except  as  expressly  provided  herein,  operate  as an
amendment to or waiver of any right,  power or remedy of Lessor under any of the
lease documents, or constitute an amendment or waiver of any provision of any of
the lease documents.

All equipment, software ("Software"), items designated as tenant improvements on
the applicable  schedule ("Tenant  Improvements")  together with all present and
future  additions,  parts,  accessories,  attachments,  substitutions,  repairs,
improvements  and  replacements  thereof or thereto,  which are the subject of a
Lease (as defined in the next  sentence)  shall be  referred to as  "Equipment".
Simultaneous with the execution and delivery of this Agreement,  the parties are
entering  into  or have  entered  into  one or more  Lease  Schedules  (each,  a
"Schedule") which refer to and incorporate by reference this Agreement,  each of
which constitutes a lease (each, a "Lease") for the Equipment specified therein.
Additional  details  pertaining  to each Lease are  specified in the  applicable
Schedule. Each Schedule that the parties hereafter enter into shall constitute a
Lease.  Lessor has no  obligation to enter into any  additional  leases with, or
extend any future financing to, Lessee other than stated in Paragraph 1 below.

                  1. LEASE.  Subject to and upon all of the terms and conditions
of this Agreement and each Schedule, Lessor hereby agrees to lease to Lessee and
Lessee hereby agrees to lease from Lessor the Equipment for the Term (as defined
in  Paragraph  2 below)  thereof.  The timing and  financial  scope of  Lessor's
obligation  to enter  into  Leases  hereunder  are  limited  as set forth in the
Commitment  Letters  executed by Lessor and Lessee,  dated as of March 20, 1997,
November  5,  1997,  May 5, 1998 and  February  5, 1999 and  attached  hereto as
Exhibits  A, B, C and D,  respectively,  and any  Commitment  Letters  hereafter
executed by Lessor and Lessee and attached  hereto as Exhibits (the  "Commitment
Letters").

                  2. TERM.  Each Lease shall be  effective  and the term of each
Lease  ("Term")  shall  commence  on  the  commencement  date  specified  in the
applicable  Schedule  which date shall not be prior to delivery,



                                      -1-
<PAGE>

acceptance and funding and, unless sooner terminated (as hereinafter  provided),
shall  expire  at the end of the  term  specified  in such  Schedule;  provided,
however,  that  obligations  due to be performed by Lessee during the Term shall
continue until they have been performed in full. Schedules will only be executed
after the delivery of the  Equipment to Lessee or upon  completion of deliveries
of items of such Equipment with aggregate cost of not less than $[...***...].

                  3. RENT.  Lessee  shall pay as rent to Lessor,  for use of the
Equipment  during the Term or Renewal Term (as defined in Paragraph  8),  rental
payments equal to the sum of all rental payments including,  without limitation,
security deposits, advance rents and interim rents payable in the amounts and on
the dates specified in the applicable  Schedule  ("Rent").  If any Rent or other
amount  payable by Lessee is not paid  within ten days after the day on which it
becomes payable, Lessee will pay on demand, as a late charge, an amount equal to
[...***...] or other amount but only to the extent  permitted by applicable law.
All  payments  provided  for herein  shall be  payable to Lessor at its  address
specified above, or at any other place designated by Lessor. Lessee's commitment
fees paid pursuant to the Commitment Letters shall be applied towards the second
month's  rent (after  deductions  for  expenses  under  paragraph  23) under the
initial  Schedules  and each  monthly  rental  payment  thereafter  until  fully
applied.

                  4. LEASE NOT CANCELABLE;  LESSEE'S  OBLIGATIONS  ABSOLUTE.  No
Lease may be canceled or terminated except as expressly provided herein. So long
as Lessor has not wrongfully  interfered  with Lessee's  quiet  enjoyment of the
Equipment,  Lessee's  obligation  to pay all Rent due or to become due hereunder
shall be  absolute  and  unconditional  and shall not be  subject  to any delay,
reduction,   set-off,  defense,   counterclaim  or  recoupment  for  any  reason
whatsoever, including any failure of the Equipment or any representations by the
manufacturer or the vendor thereof.  If the Equipment is unsatisfactory  for any
reason,  Lessee  shall make any claim  solely  against the  manufacturer  or the
vendor thereof and shall, nevertheless, pay Lessor all Rent payable hereunder.

                  5. SELECTION AND USE OF EQUIPMENT. Lessee agrees that it shall
be  responsible  for the  selection,  use of, and  results  obtained  from,  the
Equipment and any other associated equipment or services.

                  6.  WARRANTIES.  LESSOR MAKES NO  REPRESENTATION  OR WARRANTY,
EXPRESS OR IMPLIED, AS TO ANY MATTER WHATSOEVER,  INCLUDING, WITHOUT LIMITATION,
THE DESIGN OR CONDITION OF THE  EQUIPMENT OR ITS  MERCHANTABILITY,  SUITABILITY,
QUALITY OR FITNESS  FOR A  PARTICULAR  PURPOSE,  AND HEREBY  DISCLAIMS  ANY SUCH
WARRANTY.  LESSEE  SPECIFICALLY WAIVES ALL RIGHTS TO MAKE A CLAIM AGAINST LESSOR
FOR BREACH OF ANY WARRANTY  WHATSOEVER.  ONCE ACCEPTED BY LESSEE,  LESSEE LEASES
THE  EQUIPMENT  "AS IS." IN NO EVENT SHALL  LESSOR HAVE ANY  LIABILITY  FOR, NOR
SHALL LESSEE HAVE ANY REMEDY  AGAINST LESSOR FOR, ANY  LIABILITY,  CLAIM,  LOSS,
DAMAGE  OR  EXPENSE  CAUSED  DIRECTLY  OR  INDIRECTLY  BY THE  EQUIPMENT  OR ANY
DEFICIENCY OR DEFECT THEREOF OR THE OPERATION,  MAINTENANCE OR REPAIR THEREOF OR
ANY CONSEQUENTIAL  DAMAGES AS THAT TERM IS USED IN SECTION 2-719(3) OF THE MODEL
UNIFORM COMMERCIAL CODE, AS AMENDED FROM TIME TO TIME ("UCC").  Lessor grants to
Lessee,  for the sole purpose of prosecuting a claim or receiving benefits under
the  warranty,  the  benefits of any and all  warranties  made  available by the
manufacturer or the vendor of the Equipment to the extent assignable.

                  7. DELIVERY.  Lessor hereby  appoints Lessee as Lessor's agent
for the sole and limited  purpose of accepting  delivery of the  Equipment  from
each vendor  thereof.  Lessee shall pay any and all  delivery  and  installation
charges.  Lessor  shall not be liable to Lessee for any delay in, or failure of,
delivery of the Equipment.

                  8.  RENEWAL.  So long as no Event of Default  or event  which,
with the giving of notice,  the passage of time,  or both,  would  constitute an
Event of Default, shall have occurred and be continuing, or the Lessee shall not
have exercised its purchase option under Paragraph 9 hereof, Lessee may elect to
renew upon 60 days prior  written  notice to Lessor  each Lease on the terms and
conditions  of this  Agreement or as set forth in the  applicable  Schedule (the
"Renewal Term"); provided,  however, that if Lessee elects to renew, obligations
due to be performed by the Lessee during the Renewal Term shall  continue  until
they have been performed in full.  The monthly  rental

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* CONFIDENTIAL TREATMENT REQUESTED



                                      -2-
<PAGE>

payments for the Renewal Term shall be as set forth in the applicable Schedule.

                  9.  PURCHASE  OPTION.  So long as no Event of Default or event
which, with the giving of notice, the passage of time, or both, would constitute
an Event of Default, shall have occurred and be continuing,  Lessee may purchase
all, but not less than all, the Equipment covered by the applicable Lease on the
date  specified  therefor in the  applicable  Schedule  ("Purchase  Date").  The
purchase price for such Equipment shall be set forth in the applicable Schedule.
So long as no Event of Default or event  which,  with the giving of notice,  the
passage of time,  or both,  would  constitute  an Event of  Default,  shall have
occurred and be continuing,  Lessee may purchase all, but not less than all, the
Equipment  covered by the  applicable  Schedule  by the last date of the Renewal
Term (the "Alternative Purchase Date") at a purchase price equal to [...***...].
On the Purchase Date or the  Alternative  Purchase Date, as the case may be, for
any Equipment,  Lessee shall pay to Lessor the purchase price, together with all
sales and other taxes  applicable to the transfer of the Equipment and any other
amount payable and arising hereunder,  in immediately available funds, whereupon
Lessor  shall  transfer  to Lessee,  without  recourse  or warranty of any kind,
express or implied,  all of Lessor's  right,  title and  interest in and to such
Equipment  on an "As Is, Where Is" basis and file UCC-3  termination  statements
upon reasonable request by Lessee.

                  10.  OWNERSHIP;  INSPECTION;  MARKING;  FINANCING  STATEMENTS.
Lessee shall affix to the  Equipment,  other than the Tenant  Improvements,  any
labels supplied by Lessor indicating ownership of such Equipment.  The Equipment
is and shall be the sole property of Lessor.  Lessee shall have no right,  title
or  interest  therein,  except  as  lessee  under a  Lease.  Other  than  Tenant
Improvements,  the  Equipment  is and shall at all times be and remain  personal
property  and shall not become a fixture.  Lessee  shall  obtain and record such
instruments  and take such steps as may be  necessary to prevent any person from
acquiring any rights in the Equipment, other than in the Tenant Improvements, by
reason of the  Equipment  being  claimed or deemed to be real  property.  Lessee
shall make the Equipment and its maintenance records available for inspection by
Lessor at reasonable times and upon reasonable notice.  Lessee shall execute and
deliver to Lessor for filing any UCC financing  statements or similar  documents
Lessor may reasonably request.

                  11.  EQUIPMENT  USE.  Lessee agrees that the Equipment will be
operated by competent,  qualified personnel in connection with Lessee's business
for the purpose for which the  Equipment  was  designed and in  accordance  with
applicable operating  instructions,  laws and government  regulations,  and that
Lessee  shall use all  reasonable  precautions  to prevent loss or damage to the
Equipment  from fire and other  hazards.  Lessee  shall  procure and maintain in
effect all orders,  licenses,  certificates,  permits,  approvals  and  consents
required by federal,  state or local laws or by any governmental body, agency or
authority in connection  with the delivery,  installation,  use and operation of
the Equipment.

                  12. MAINTENANCE.  Lessee, at its sole cost and expense,  shall
keep the Equipment in a suitable  environment as specified by the manufacturer's
guidelines or the  equivalent  and meet all  recertification  requirements,  and
shall  maintain  the  Equipment  in its original  condition  and working  order,
ordinary wear and tear  excepted.  At the reasonable  request of Lessor,  Lessee
shall furnish all proof of maintenance.

                  13.  ALTERATION;  MODIFICATIONS;  PARTS.  Lessee  may alter or
modify  the  Equipment  only with the  prior  written  consent  of  Lessor.  Any
alteration shall be removed and the Equipment restored to its normal,  unaltered
condition  at Lessee's  expense  (without  damaging the  Equipment's  originally
intended  function  or its  value)  prior  to its  return  to  Lessor.  Any part
installed in connection with warranty or maintenance  service or which cannot be
removed in  accordance  with the  preceding  sentence  shall be the  property of
Lessor.

                  14.  RETURN  OF  EQUIPMENT.  Except  for  Equipment  that  has
suffered a Casualty  Loss (as defined in Paragraph 15 below) and is not required
to be repaired  pursuant to Paragraph 15 below or Equipment  purchased by Lessee
pursuant to Paragraph 9 above,  upon  expiration of the Renewal Term of a Lease,
or upon demand by Lessor  pursuant to Paragraph 22 below,  Lessee shall  contact
Lessor for shipping  instructions and, at Lessee's own risk,  immediately return
the Equipment,  freight prepaid,  to a location in the continental United States
specified by Lessor.  At the time of such return to Lessor,  the Equipment shall
(i) be in the operating order,  repair

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* CONFIDENTIAL TREATMENT REQUESTED



                                      -3-
<PAGE>

and  condition as required by or specified  in the original  specifications  and
warranties  of each  manufacturer  and vendor  thereof,  ordinary  wear and tear
excepted, and meet all recertification requirements and (ii) be capable of being
promptly assembled and operated by a third party purchaser or third party lessee
without  further  repair,  replacement,  alterations  or  improvements,  and  in
accordance and compliance with any and all statutes, laws, ordinances, rules and
regulations of any governmental  authority or any political  subdivision thereof
applicable  to the use and  operation  of the  Equipment.  Except  as  otherwise
provided under Paragraph 9 hereof, at least thirty days before the expiration of
the Renewal  Term,  Lessee shall give Lessor  notice of its intent to return the
Equipment at the end of such Renewal Term. During the thirty-day period prior to
the end of the Renewal Term,  Lessor and its  prospective  purchasers or lessees
shall have,  upon not less than two  business  days' prior  notice to Lessee and
during normal  business  hours, or at any time and without prior notice upon the
occurrence and  continuance  of an Event of Default,  the right of access to the
premises on which the Equipment is located to inspect the Equipment,  and Lessee
shall  cooperate  in  all  other  respects  with  Lessor's  remarketing  of  the
Equipment.  The provisions of this Paragraph 14 are of the essence of the Lease,
and upon application to any court of equity having jurisdiction in the premises,
Lessor  shall  be  entitled  to  a  decree  against  Lessee  requiring  specific
performance of the covenants of Lessee set forth in this Paragraph 14. If Lessee
fails to return the Equipment  when  required,  the terms and  conditions of the
Lease shall  continue to be  applicable  and Lessee  shall  continue to pay Rent
until the Equipment is received by Lessor.

                  15. CASUALTY INSURANCE;  LOSS OR DAMAGE. Lessee will maintain,
at its own expense,  liability  and property  damage  insurance  relating to the
Equipment, insuring against such risks as are customarily insured against on the
type of equipment  leased  hereunder by businesses in which Lessee is engaged in
such amounts, in such form, and with insurers satisfactory to Lessor;  provided,
however,  that the amount of insurance  against damage or loss shall not be less
than the greater of (a) the [...***...] of the Equipment and (b) the [...***...]
of  the  Equipment  specified  in  the  applicable  Schedule  [...***...].  Each
liability   insurance   policy  shall  provide  coverage   (including,   without
limitation,  personal injury  coverage) of not less than  $[...***...]  for each
occurrence,  and shall name Lessor as an additional  insured;  and each property
damage  policy  shall  name  Lessor as sole loss  payee and all  policies  shall
contain a clause requiring the insurer to give Lessor at least thirty days prior
written  notice of any  alteration in the terms or  cancellation  of the policy.
Lessee shall furnish an insurance  certificate or other evidence satisfactory to
Lessor that the required  insurance  coverage is in effect;  provided,  however,
Lessor  shall have no duty to  ascertain  the  existence  of or to  examine  the
insurance  certificates  or policies to advise Lessee if the insurance  coverage
does not comply with the  requirements  of this  Paragraph.  If Lessee  fails to
insure  the  Equipment  as  required,  Lessor  shall  have the right but not the
obligation to obtain such insurance,  and the cost of the insurance shall be for
the  account  of Lessee  due as part of the next due Rent.  Lessee  consents  to
Lessor's release,  upon its failure to obtain appropriate insurance coverage, of
any and all  information  necessary  to obtain  insurance  with  respect  to the
Equipment or Lessor's interest therein.

                  Until the  Equipment  is returned to and received by Lessor as
provided in  Paragraph  14 above,  Lessee shall bear the entire risk of theft or
destruction of, or damage to, the Equipment including,  without limitation,  any
condemnation,  seizure or  requisition  of title or use  ("Casualty  Loss").  No
Casualty Loss shall relieve  Lessee from its  obligations  to pay Rent except as
provided  in clause (b) below.  When any  Casualty  Loss  occurs,  Lessee  shall
immediately notify Lessor and, at the option of Lessor, shall promptly (a) place
such  Equipment  in good repair and working  order;  or (b) pay Lessor an amount
equal to the  [...***...]  of such  Equipment and all other  amounts  (excluding
Rent) payable by Lessee  hereunder,  together with a late charge on such amounts
at a rate per annum equal to the [...***...] hereunder (as reasonably determined
by Lessor)  from the date of the  Casualty  Loss  through the date of payment of
such amounts,  whereupon  Lessor shall transfer to Lessee,  without  recourse or
warranty (express or implied),  all of Lessor's interest, if any, in and to such
Equipment on an "AS IS, WHERE IS" basis.  The proceeds of any insurance  payable
with respect to the  Equipment  shall be applied,  at the option of Lessee if no
Event of Default has occurred and is continuing  (and otherwise at the option of
Lessor),  either  towards (i) repair of the  Equipment or (ii) payment of any of
Lessee's  obligations  hereunder.  Lessee  hereby  appoints  Lessor as  Lessee's
attorney-in-fact  to make claim for, receive payment of, and execute and endorse
all  documents,  checks or drafts issued with respect to any Casualty Loss under
any insurance policy relating to the Equipment.

                  16.  TAXES.  Lessee shall pay when due, and indemnify and hold
Lessor harmless from, all sales, use, excise and other taxes,  charges, and fees
(including,  without  limitation,  income,  franchise,  business and

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* CONFIDENTIAL TREATMENT REQUESTED



                                      -4-
<PAGE>

occupation, gross receipts, licensing, registration, titling, personal property,
stamp and interest  equalization  taxes,  levies,  imposts,  duties,  charges or
withholdings of any nature), and if resulting from an act or omission of Lessee,
any fines, penalties or interest thereon,  imposed or levied by any governmental
body,  agency or tax authority  upon or in connection  with the  Equipment,  its
purchase,  ownership,  delivery,  leasing,  possession, use or relocation of the
Equipment or otherwise in connection with the transactions  contemplated by each
Lease or the Rent  thereunder,  excluding taxes on or measured by the net income
of Lessor.  Upon request,  Lessee will provide  proof of payment.  Unless Lessor
elects otherwise,  Lessor will pay all property taxes on the Equipment for which
Lessee shall reimburse Lessor promptly upon request and proof of payment. Lessee
shall timely  prepare and file all reports and returns  which are required to be
made with respect to any  obligation  of Lessee under this  Paragraph 16. Lessee
shall, to the extent  permitted by law, cause all billings of such fees,  taxes,
levies,  imposts,  duties,  withholdings and governmental  charges to be made to
Lessor in care of Lessee.  Upon request,  Lessee will provide Lessor with copies
of all such billings.  Lessee shall have the option to contest taxes  diligently
and in good faith as long as Lessee maintains  adequate  reserves for such taxes
measured in accordance with General Accepted Accounting Principles.

                  17.  LESSOR'S   PAYMENT.   If  Lessee  fails  to  perform  its
obligations under Paragraph 15 or 16 above, or Paragraph 23 below,  Lessor shall
have  the  right  to  substitute  performance,   in  which  case,  Lessee  shall
immediately reimburse Lessor therefor.

                  18. GENERAL INDEMNITY.  Each Lease is a net lease.  Therefore,
Lessee shall indemnify Lessor and its successors and assigns  against,  and hold
Lessor  and its  successors  and  assigns  harmless  from,  any and all  claims,
actions,  damages,   obligations,   liabilities  and  all  costs  and  expenses,
including, without limitation,  reasonable legal fees, incurred by Lessor or its
successors and assigns arising out of each Lease including,  without limitation,
the purchase, ownership,  delivery, lease, possession,  maintenance,  condition,
use or return of the  Equipment,  or arising by  operation  of law,  except that
Lessee shall not be liable for any claims,  actions,  damages,  obligations  and
costs and expenses  determined  by a  non-appealable,  final order of a court of
competent  jurisdiction  have  occurred as a result of the gross  negligence  or
willful  misconduct of Lessor or its successors and assigns.  Lessee agrees that
upon written  notice by Lessor of the  assertion of any claim,  action,  damage,
obligation,  liability or lien, Lessee shall assume full  responsibility for the
defense  thereof,  provided that Lessor's  failure to give such notice shall not
limit or  otherwise  affect its  rights  hereunder  except to the extent  Lessee
incurs a loss as a direct result of such failure.  Any payment  pursuant to this
Paragraph  (except  for any payment of Rent) shall be of such amount as shall be
necessary  so that,  after  payment of any taxes  required to be paid thereon by
Lessor,  including taxes on or measured by the net income of Lessor, the balance
will equal the amount due  hereunder.  The  provisions  of this  Paragraph  with
regard to  matters  arising  during a Lease  shall  survive  the  expiration  or
termination of such Lease.

                  19. ASSIGNMENT BY LESSEE.  Lessee shall not, without the prior
written consent of Lessor, (a) assign, transfer,  pledge or otherwise dispose of
any Lease or  Equipment,  or any  interest  therein;  (b)  sublease  or lend any
Equipment or permit it to be used by anyone other than Lessee and its  employees
agents, representatives, contractors and other authorized persons, provided that
Lessee shall  indemnify and hold Lessor and its successors and assigns  harmless
from any liability  arising  under,  or in connection  with such persons' use or
operation  of the  Equipment;  or (c)  move  any  Equipment  from  the  location
specified  for it in the  applicable  Schedule,  except  that  Lessee  may  move
Equipment to another  location within the United States provided that Lessee has
delivered  to Lessor (A) prior  written  notice  thereof  and (B) duly  executed
financing  statements  and other  agreements  and  instruments  (all in form and
substance  satisfactory  to Lessor)  necessary or, in the opinion of the Lessor,
desirable  to  protect  Lessor's  interest  in such  Equipment.  Notwithstanding
anything to the contrary in the immediately preceding sentence,  Lessee may keep
any Equipment  consisting of motor  vehicles or rolling stock at any location in
the United States.

                  20.  ASSIGNMENT  BY LESSOR.  Lessor may assign its interest or
grant a  security  interest  in any  Lease  and the  Equipment  individually  or
together,  in whole or in part.  If Lessee is given  written  notice of any such
assignment,  it shall  immediately  make all payments of Rent and other  amounts
hereunder  directly to such  assignee.  Each such assignee shall have all of the
rights of Lessor  under  each  Lease  assigned  to it.  Lessee  shall not assert
against any such assignee any set-off,  defense or counterclaim  that Lessee may
have against  Lessor or any other  person.  Notwithstanding  any  assignment  by
Lessor,  Lessor shall not be relieved of its obligations under any Lease, but in
no event shall Lessor be liable for any act or omission of its assignee.

                                      -5-
<PAGE>

                  21. DEFAULT; NO WAIVER.  Lessee or any guarantor of any or all
of the  obligations  of Lessee  hereunder  (together  with  Lessee,  the  "Lease
Parties") shall be in default under each Lease upon the occurrence of any of the
following  events (each, an "Event of Default"):  (a) Lessee fails to pay within
ten  days of when  due any  amount  required  to be paid by  Lessee  under or in
connection with any Lease;  (b) any of the Lease Parties fails to perform in any
material  respect any other  provision  under or in  connection  with a Lease or
violates in any  material  respect any of the  covenants or  agreements  of such
Lease Parties under or in connection with a Lease; (c) any  representation  made
or financial  information  delivered  or  furnished by any of the Lease  Parties
under or in connection  with a Lease shall prove to have been  inaccurate in any
material respect when made; (d) any of the Lease Parties makes an assignment for
the benefit of creditors,  whether voluntary or involuntary,  or consents to the
appointment of a trustee or receiver, or if either shall be appointed for any of
the Lease Parties or for a substantial  part of its property without its consent
and, in the case of any such  involuntary  proceeding,  such proceeding  remains
undismissed or unstayed for forty-five days following the commencement  thereof;
(e) any petition or  proceeding  is filed by or against any of the Lease Parties
under any Federal or State  bankruptcy or insolvency code or similar law and, in
the case of any such  involuntary  petition  or  proceeding,  such  petition  or
proceeding  remains  undismissed or unstayed for  forty-five  days following the
filing or  commencement  thereof,  or any of the Lease  Parties takes any action
authorizing any such petition or proceeding;  (f) any of the Lease Parties fails
to pay when due any indebtedness for borrowed money or under  conditional  sales
or  installment  sales  contracts or similar  agreements,  leases or obligations
evidenced by bonds, debentures, notes or other similar agreements or instruments
to any creditor  (including  Lessor under any other agreement) after any and all
applicable  cure  periods  therefor  shall have  elapsed if the amount  involved
exceeds  $[...***...]  in the  aggregate;  (g) any  judgment  shall be  rendered
against any of the Lease  Parties  which shall  remain  unpaid or unstayed for a
period of sixty days;  (h) any of the Lease Parties shall  dissolve,  liquidate,
wind up or cease its business, sell or otherwise dispose of all or substantially
all of its assets;  (i) any of the Lease Parties shall amend or modify its name,
unless  such  Lease  Party  delivers  to Lessor  thirty  days  prior to any such
proposed  amendment  or  modification   written  notice  of  such  amendment  or
modification and within ten days before such amendment or modification  delivers
executed financing statements (in form and substance satisfactory to the Lessor)
provided  that  Lessee  shall have 10  business  days  after  notice to cure any
default  under this  paragraph  (i); (j) any of the Lease Parties shall merge or
consolidate  with any other  entity or make any  material  change in its capital
structure,  in each case without Lessor's prior written consent, which shall not
be unreasonably  withheld; (k) any of the Lease Parties shall suffer any loss or
suspension  of any material  license,  permit or other right or asset which loss
has a material adverse effect on Lessee's ability to perform hereunder,  or fail
generally  to pay its debts as they  mature,  or call a meeting for  purposes of
compromising  its debts; or (l) any of the Lease Parties shall deny or disaffirm
its obligations  hereunder or under any of the documents delivered in connection
herewith.

                  22. REMEDIES. Upon the occurrence and continuation of an Event
of Default  for ten days after  notice  for a payment  Event of Default  and for
thirty days after notice for all other Events of Default,  Lessor shall have the
right,  in its sole  discretion,  to exercise  any one or more of the  following
remedies:  (a)  terminate  each  Lease;  (b)  declare any and all Rent and other
amounts then due and any and all Rent and other amounts to become due under each
Lease (collectively,  the "Lease Obligations")  immediately due and payable; (c)
take  possession of any or all items of  Equipment,  wherever  located,  without
demand,  notice,  court order or other process of law, and without liability for
entry to Lessee's  premises,  for damage to Lessee's property or otherwise;  (d)
demand  that  Lessee  immediately  return  any or all  Equipment  to  Lessor  in
accordance with Paragraph 14 above,  and, for each day that Lessee shall fail to
return any item of  Equipment,  Lessor  may  demand an amount  equal to the Rent
payable for such  Equipment in accordance  with  Paragraph 14 above;  (e) lease,
sell or otherwise dispose of the Equipment in a commercially  reasonable manner,
with or without  notice and on public or private bid; (f) recover the  following
amounts  from the  Lessee  (as  damages,  including  reimbursement  of costs and
expenses,  liquidated for all purposes and not as a penalty):  (i) all costs and
expenses of Lessor reimbursable to it hereunder,  including, without limitation,
expenses of disposition of the  Equipment,  reasonable  legal fees and all other
amounts  specified in Paragraph 23 below; (ii) an amount equal to the sum of (A)
any accrued and unpaid Rent through the later of (1) the date of the  applicable
default or (2) the date that Lessor has obtained  possession of the Equipment or
such other  date as Lessee has made an  effective  tender of  possession  of the
Equipment to Lessor (the  "Default  Date") and (B) if Lessor  resells or re-lets
the  Equipment,  Rent at the  periodic  rate  provided for in each Lease for the
additional period that it takes Lessor to resell or re-let all of the Equipment;
(iii) the present value of all future Rent reserved in the Leases and

- --------------------
* CONFIDENTIAL TREATMENT REQUESTED

                                      -6-
<PAGE>

contracted  to be paid  over the  unexpired  Term of the  Leases  discounted  at
[...***...]   simple  interest  per  annum;   (iv)  the  present  value  of  the
reversionary  value of the  Equipment  as of the  expiration  of the Term of the
applicable  Lease  as  set  forth  on  the  applicable  Schedule  discounted  at
[...***...]  simple interest;  and (v) any  indebtedness for Lessee's  indemnity
under Paragraph 18 above,  plus a late charge at the rate specified in Paragraph
3 above,  less the amount received by Lessor, if any, upon sale or re-let of the
Equipment;  and (g)  exercise  any other  right or remedy to recover  damages or
enforce the terms of the Leases. Upon the occurrence and continuance of an Event
of Default or an event  which with the giving of notice or the  passage of time,
or both,  would  result in an Event of  Default,  Lessor  shall  have the right,
whether or not Lessor has made any demand or the obligations of Lessee hereunder
have matured,  to  appropriate  and apply to the payment of the  obligations  of
Lessee hereunder all security  deposits and other deposits  (general or special,
time or  demand,  provisional  or  final)  now or  hereafter  held by and  other
indebtedness or property now or hereafter owing by Lessor to Lessee.  Lessor may
pursue any other rights or remedies  available  at law or in equity,  including,
without limitation, rights or remedies seeking damages, specific performance and
injunctive  relief.  Any  failure of Lessor to  require  strict  performance  by
Lessee,  or any  waiver  by  Lessor  of any  provision  hereunder  or under  any
Schedule,  shall not be  construed as a consent or waiver of any other breach of
the same or of any other  provision.  Any  amendment or waiver of any  provision
hereof or under any Schedule or consent to any  departure by Lessee  herefrom or
therefrom shall be in writing and signed by Lessor.

                  No right or remedy is exclusive of any other  provided  herein
or permitted by law or equity.  All such rights and remedies shall be cumulative
and may be enforced concurrently or individually from time to time.

                  23.  LESSOR'S  EXPENSE.  Lessee shall pay Lessor on demand all
its  reasonable  expenses  which  shall not exceed the amounts set forth in each
Commitment  Letter without the written consent of Lessee  (including  reasonable
legal fees and expenses) incurred in connection with the preparation,  execution
and  delivery  of  this  Agreement  and  any  other  agreement  and  transaction
contemplated  hereby and all costs and  expenses  in  protecting  and  enforcing
Lessor's  rights  and  interests  in each  Lease and the  Equipment,  including,
without limitation, legal, collection and remarketing fees and expenses incurred
by Lessor in enforcing  the terms,  conditions  or  provisions of each Lease or,
upon the occurrence and continuation of an Event of Default.

                  24. LESSEE'S  WAIVERS.  To the extent  permitted by applicable
law,  Lessee  hereby  waives any and all rights and  remedies  conferred  upon a
lessee by Sections  2A-508 through 2A-522 of the UCC;  provided,  however,  that
Lessee  shall have the right to recover  damages  from  Lessor for any breach by
Lessor of its  obligations  under this  Agreement.  To the extent  permitted  by
applicable law, Lessee also hereby waives any rights now or hereafter  conferred
by statute or otherwise which may require Lessor to sell, lease or otherwise use
any  Equipment in  mitigation  of Lessor's  damages as set forth in Paragraph 22
above or which may otherwise  limit or modify any of Lessor's rights or remedies
under Paragraph 22, except that Lessee shall have the right to require Lessor to
convey to Lessee, without representation,  warranty or recourse, all of Lessor's
rights,  title and  interest  in and to the  Equipment  upon  Lessor's  receipt,
following an event of default and the exercise of the Lessor's remedies,  of the
amounts  specified in Paragraph  22(f).  Any action by Lessee against Lessor for
any default by Lessor under any Lease shall be  commenced  within one year after
any such cause of action accrues.

                  25.  NOTICES;  ADMINISTRATION.  Except as  otherwise  provided
herein, all notices, approvals, consents, correspondence or other communications
required or desired to be given hereunder shall be given in writing and shall be
delivered by overnight  courier,  hand delivery or certified or registered mail,
postage prepaid, if to Lessor, then to Technology Finance Division, 76 Batterson
Park Road, Farmington,  Connecticut 06032, Attention:  Assistant Vice President,
Lease  Administration,  with a copy to Lessor at Riverway II, West Office Tower,
9399 West Higgins Road, Rosemont,  Illinois 60018, Attention:  Legal Department,
if to Lessee, then to Sugen, Inc., 351 Galveston Drive, Redwood City, California
94063-4720,  Attention: Vice President Finance or such other address as shall be
designated  by  Lessee  or  Lessor to the  other  party.  All such  notices  and
correspondence shall be effective when received.

                  26. REPRESENTATIONS.  Lessee represents and warrants to Lessor
that (a) Lessee is duly organized,  validly  existing and in good standing under
the laws of the State of its  incorporation;  (b) the  execution,  delivery  and
performance by Lessee of this Agreement are within  Lessee's  powers,  have been
duly authorized by all

- --------------------
* CONFIDENTIAL TREATMENT REQUESTED


                                      -7-
<PAGE>

necessary action, and do not and will not contravene (i) Lessee's organizational
documents  or (ii) any law or  contractual  restriction  binding on or affecting
Lessee; (c) no authorization or approval or other action by, and no notice to or
filing with, any  governmental  authority or regulatory body is required for the
due execution,  delivery and performance by Lessee of this  Agreement;  (d) each
Lease constitutes the legal, valid and binding obligations of Lessee enforceable
against  Lessee  in  accordance  with its  terms  except  as may be  limited  by
bankruptcy, reorganization, receivership, insolvency or other laws affecting the
enforcement of creditor's rights  generally;  (e) to the knowledge of Lessee the
cost of each item of Equipment does not exceed the fair and usual price for such
type of  equipment  purchased  in like  quantity  and  reflects  all  discounts,
rebates,  and  allowances  for the  Equipment  (including,  without  limitation,
discounts for advertising,  prompt payment,  testing or other services) given to
the  Lessee  by the  manufacturer,  supplier  or any other  person;  and (f) all
information  supplied by Lessee to Lessor in connection  herewith is correct and
does not omit any material  statement  necessary to insure that the  information
supplied is not misleading.

                  27. FURTHER  ASSURANCES.  Lessee,  upon the request of Lessor,
will  execute,  acknowledge,  record or file,  as the case may be, such  further
documents and do such further acts as may be reasonably necessary,  desirable or
proper to carry out more  effectively  the  purposes of this  Agreement.  Lessee
hereby appoints Lessor as its limited  attorney-in-fact  to execute on behalf of
Lessee  and  authorizes  Lessor  to  file  without  Lessee's  signature  any UCC
financing statements and amendments Lessor deems advisable.

                  28. FINANCIAL STATEMENTS.  Lessee shall deliver to Lessor: (a)
as soon as  available,  but not later than 120 days after the end of each fiscal
year of Lessee  and its  consolidated  subsidiaries,  the  consolidated  balance
sheet, income statement and statements of cash flows and shareholders equity for
Lessee and its consolidated  subsidiaries (the "Financial  Statements") for such
year, reported on by independent certified public accountants without an adverse
qualification;  and (b) as soon as  available,  but not later than 60 days after
the end of each of the first three fiscal  quarters in any fiscal year of Lessee
and its  consolidated  subsidiaries,  the Financial  Statements  for such fiscal
quarter,  as filed with the SEC.  Lessee shall also deliver to Lessor as soon as
available copies of all press releases and other similar  communications  issued
by Lessee and upon request of Lessor.

                  29. CONSENT TO JURISDICTION. Lessee irrevocably submits to the
jurisdiction  of any Illinois state or federal court sitting in Illinois for any
action  or  proceeding  arising  out of or  relating  to this  Agreement  or the
transactions  contemplated hereby, and Lessee irrevocably agrees that all claims
in respect of any such action or proceeding  may be heard and determined in such
Illinois state or federal court.

                  30. WAIVER OF JURY TRIAL.  LESSEE AND LESSOR IRREVOCABLY WAIVE
ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM ARISING OUT
OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY.

                  31. FINANCE LEASE.  Lessee and Lessor agree that each Lease is
a  "Finance  Lease"  as  defined  by  Section   2A-103(g)  of  the  UCC.  Lessee
acknowledges  that Lessee has reviewed and approved each written Supply Contract
(as defined by UCC 2A-103(y))  covering Equipment purchased from each "Supplier"
(as defined by UCC 2A-103(x)) thereof.

                  32. NO AGENCY. Lessee acknowledges and agrees that neither the
manufacturer nor supplier,  nor any salesman,  representative  or other agent of
the manufacturer or supplier, is an agent of Lessor. No salesman, representative
or agent of the  manufacturer  or supplier is  authorized  to waive or alter any
term or condition of this Agreement or any Schedule and no  representation as to
the Equipment or any other matter by the  manufacturer  or supplier shall in any
way affect  Lessee's duty to pay Rent and perform its other  obligations  as set
forth in this Agreement or any Schedule.

                  33.  SPECIAL TAX  INDEMNIFICATION.  Lessee  acknowledges  that
Lessor,  in  determining  the Rent due  hereunder,  has assumed that certain tax
benefits as are provided to an owner of property under the Internal Revenue Code
of 1986, as amended (the "Code"), and under applicable state tax law, including,
without  limitation,  depreciation  deductions under Section 168(b) of the Code,
and deductions  under Section 163 of the Code in an amount at least equal to the
amount of interest  paid or accrued by Lessor with  respect to any  indebtedness
incurred by Lessor in financing its purchase of the Equipment,  are available to
Lessor as a result of the lease of the



                                      -8-
<PAGE>

Equipment. In the event Lessor is unable to obtain such tax benefits as a result
of an act or omission  of Lessee of which  Lessee has prior  written  notice and
opportunity  of comply,  is required to include in income any amount  other than
the Rent or is required to recognize  income in respect of the Rent earlier than
anticipated pursuant to this Agreement,  Lessee shall pay Lessor additional rent
("Additional Rent") in a lump sum in an amount needed to provide Lessor with the
same  after-tax  yield and  after-tax  cash flow as would have been  realized by
Lessor had Lessor (i) been able to obtain such tax  benefits,  and (ii) not been
required to recognize  income in respect of the Rent  earlier  than  anticipated
pursuant to this  Agreement.  The  Additional  Rent shall be computed by Lessor,
which  computation  shall be binding  on Lessee  absent  good  faith  contest by
Lessee.  The  Additional  Rent shall be due  immediately  upon written notice by
Lessor to Lessee of Lessor's inability to obtain tax benefits,  the inclusion of
any amount in income other than the Rent or the recognition of income in respect
of the Rent earlier than anticipated pursuant to this Agreement.  The provisions
of this Paragraph 33 shall survive the termination of this Agreement.

                  34. GOVERNING LAW; SEVERABILITY.  EACH LEASE SHALL BE GOVERNED
BY THE LAWS OF THE STATE OF ILLINOIS  WITHOUT  GIVING  EFFECT TO THE CONFLICT OF
LAW  PRINCIPLES  THEREOF.  IF ANY  PROVISION  SHALL  BE  HELD TO BE  INVALID  OR
UNENFORCEABLE, THE VALIDITY AND ENFORCEABILITY OF THE REMAINING PROVISIONS SHALL
NOT IN ANY WAY BE AFFECTED OR IMPAIRED.

LESSEE  ACKNOWLEDGES  THAT  LESSEE  HAS READ THIS  AGREEMENT  AND THE  SCHEDULES
HERETO,  UNDERSTANDS THEM, AND AGREES TO BE BOUND BY THEIR TERMS AND CONDITIONS.
FURTHER, LESSEE AND LESSOR AGREE THAT THIS AGREEMENT AND THE SCHEDULES DELIVERED
AND SIGNED BY LESSEE AND LESSOR IN CONNECTION HEREWITH FROM TIME TO TIME AND THE
COMMITMENT  LETTERS,  ARE THE COMPLETE AND EXCLUSIVE  STATEMENT OF THE AGREEMENT
BETWEEN THE PARTIES,  SUPERSEDING  ALL  PROPOSALS OR PRIOR  AGREEMENTS,  ORAL OR
WRITTEN,  AND ALL OTHER  COMMUNICATIONS  BETWEEN  THE  PARTIES  RELATING  TO THE
SUBJECT MATTER HEREOF.


                                      -9-
<PAGE>


                  IN WITNESS WHEREOF, the parties hereto have executed or caused
this Agreement to be duly executed by their duly authorized  officers as of this
26th day of February, 1999.




                     SUGEN, INC.


                     By: /s/ James Knighton
                        --------------------------------------------------------
                        Name: James Knighton
                        Title: Senior Vice President and Chief Financial Officer
                        Hereunto Duly Authorized
                        Federal Identification Number 13-3629196


                     TRANSAMERICA BUSINESS CREDIT CORPORATION



                     By: /s/ Gary P. Moro
                        --------------------------------------------------------
                        Name: Gary P. Moro
                        Title: Vice President


                                      -10-




                                                                   EXHIBIT 10.81

CONFIDENTIAL


Date:             February 22, 1999

To:               Stephen Evans-Freke
                  Chairman and Chief Executive Officer

cc:               Susan Kanaya, Treasurer, SUGEN, Inc.
                  Suzanne Hooper, Cooley Godward LLP

From:             Donald E. Nickelson
                  Chairman of the Compensation Committee
                  SUGEN, Inc. Board of Directors

Reference:        Modification of July 21, 1998 Letter Agreement


Dear Stephen:

At its meeting on February 22, 1999, the Compensation  Committee of SUGEN Inc.'s
Board of Directors agreed to modify the second paragraph of its letter agreement
with you dated July 21,  1998.  As  modified,  such  paragraph  will read in its
entirety as follows:

         "In  consideration  for your  commitment  to  serve as Chief  Executive
         Officer for up to one further year,  SUGEN  promises to transfer to you
         up to  100,000  shares of fully  paid-up  common  stock of SUGEN,  Inc.
         ("Shares"),  provided the following conditions are satisfied.  If SUGEN
         appoints a new Chief Executive  Officer prior to January 1, 2000, SUGEN
         will  transfer  50,000  shares  to you  within 10 days  following  such
         appointment,  but not earlier than January 4, 1999. If SUGEN (including
         its affiliated  entities)  raises at least an additional $30 million in
         new money  prior to July 1,  1999,  SUGEN will  transfer  to you 50,000
         Shares within 10 days following the completion of such transaction, but
         not earlier than January 4, 1999. Both  contingencies may be met by any
         means in order to count for these purposes.  Until the time of transfer
         under the foregoing  conditions,  you are not a shareholder of SUGEN in
         respect of any of the 100,000  Shares.  Notwithstanding  the foregoing,
         should a Change of Control  (as  hereinafter  defined)  occur  prior to
         January 1, 2000, SUGEN will transfer to you, not later than the date of
         such Change of Control,  such number of the 100,000  shares as have not
         already been transferred to you. For this purpose,  "Change of Control"
         means  any  consolidation  or  merger  of  SUGEN,  Inc.  with any other
         corporation  (other than a wholly-owned  subsidiary of SUGEN,  Inc.) in
         which  the  stockholders  of  SUGEN,  Inc.  immediately  prior  to such
         consolidation  or merger do not own in excess of fifty percent (50%) of
         the equity interests in the surviving corporation in such consolidation
         or

                                       1.


<PAGE>

         merger  immediately after consummation of such consolidation or merger,
         any sale or  transfer  of all or  substantially  all of the  assets  of
         SUGEN,  Inc.,  or any  share  exchange  pursuant  to  which  all of the
         outstanding  shares of SUGEN,  Inc.'s Common Stock are  exchanged  into
         other  securities   (except  securities  of  an  entity  in  which  the
         stockholders  of SUGEN,  Inc.  immediately  prior to such  exchange own
         greater than fifty  percent (50%) of the equity  interests  immediately
         after such exchange) or property."

In all other respects,  the letter agreement dated July 21, 1998 remains in full
force and effect.

If this proposal is acceptable to you,  please  confirm this by signing below in
the indicated space on each copy of this letter, returning one to me with copies
to Susan Kanaya and Suzanne Hooper, and retaining the other for your records.

                                   Sincerely,


                                   Donald E. Nickelson


Agreed:



______________________________________        Date: ____________________________
Stephen Evans-Freke
Chairman and Chief Executive Officer

                                       2.

<TABLE> <S> <C>


<ARTICLE>                     5
<LEGEND>
     The schedule  contains  summary  financial  information  extracted from the
     Company's  Form  10-Q for the three  months  ended  March  31,  1999 and is
     qualified in its entirety by reference to such financial statements.
</LEGEND>
<MULTIPLIER>                                   1,000

<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                              DEC-31-1999
<PERIOD-START>                                 JAN-01-1999
<PERIOD-END>                                   MAR-31-1999
<CASH>                                          37,392
<SECURITIES>                                    24,507
<RECEIVABLES>                                        0
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                                63,706
<PP&E>                                          14,279
<DEPRECIATION>                                   6,567
<TOTAL-ASSETS>                                  74,525
<CURRENT-LIABILITIES>                           23,614
<BONDS>                                              0
                                0
                                          0
<COMMON>                                       160,609
<OTHER-SE>                                    (147,248)
<TOTAL-LIABILITY-AND-EQUITY>                    74,525
<SALES>                                              0
<TOTAL-REVENUES>                                 4,262
<CGS>                                                0
<TOTAL-COSTS>                                        0
<OTHER-EXPENSES>                                16,528
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 487
<INCOME-PRETAX>                                (14,905)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                            (14,905)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   (14,905)
<EPS-BASIC>                                     (.89)
<EPS-DILUTED>                                     (.89)



</TABLE>


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