SUGEN INC
8-K, 1999-03-29
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<TABLE>

                                           SECURITIES AND EXCHANGE COMMISSION

                                                 Washington, D.C. 20549

                                                        FORM 8-K
                                                     CURRENT REPORT
                                         Pursuant to Section 13 or 15(d) of the
                                            Securities Exchange Act of 1934

                            Date of Report (Date of earliest event reported): March 24, 1999

                                                      SUGEN, INC.
                                 (Exact name of registrant as specified in its charter)
<CAPTION>

                Delaware                                0-24814                             13-3629196
<S>  <C>                                         <C>                           <C>
     (State or other jurisdiction of             (Commission File No.)         (I.R.S. Employer Identification No.)
     incorporation or organization)


                                                 230 East Grand Avenue
                                         South San Francisco, California 94080
                                 (Address of principal executive offices and zip code)

                           Registrant's telephone number, including area code: (650) 553-8300


</TABLE>

<PAGE>


Item 5.  Other Events.

On March 22, 1999, SUGEN,  Inc. (the "Company")  announced the private placement
of $28,000,000  aggregate  principal amount of its 12% Senior  Convertible Notes
due 2002 (the  "Notes") and warrants  (the  "Warrants")  to acquire  $21,000,000
principal  amount of 12% Senior  Convertible  Notes (the "Warrant  Notes").  The
private  placement closed on March 24, 1999 (the "Closing  Date").  In addition,
the  holders of the  outstanding  balance  of  approximately  $5,700,000  of the
Company's 5% Senior Custom Convertible Notes issued in September 1997 (the "1997
Notes") have agreed,  subject to certain  conditions set forth in the Securities
Purchase and Exchange  Agreement  attached  hereto as Exhibit 4.1, that the 1997
Notes will be converted into common stock of the Company (the "Common Stock") in
accordance  with the terms of the 1997 Notes or exchanged for  additional  Notes
and Warrants at a premium of 125-132% of the outstanding principal amount of the
1997 Notes within 135 days of the Closing Date. The exchange of all  outstanding
1997 Notes would result in the issuance of an  additional  $7,368,073  principal
amount of Notes and  Warrants  to purchase an  additional  $5,526,055  principal
amount of Warrant Notes. The following summary of certain terms of the Notes and
Warrants does not purport to be a complete  description  and is qualified in its
entirety  by  reference  to  the  forms  of  Securities  Purchase  and  Exchange
Agreement,  Note and Warrant, each of which are incorporated by reference herein
and copies of which are filed as Exhibits 4.1, 4.2 and 4.3 to this Form 8-K.

The Notes were sold at par,  mature in March 2002 and bear  interest at the rate
of 12% per annum, payable in cash or, at the election of the Company,  shares of
Common  Stock.  The  principal  amount of the Notes,  together  with accrued and
unpaid  interest,  is  convertible  into shares of Common  Stock at a conversion
price of $20.50  (the  "Conversion  Price").  Among other  covenants,  the Notes
include  covenants  that  require  the  Company  to meet  certain  cash and cash
equivalent maintenance requirements.

The  Warrants  are  exercisable  at  any  time  until  March  2001,  subject  to
restrictions  on the  level  of  exercises  in any  period  as set  forth in the
Warrants.  During  the term of the  Warrants,  if the  closing  bid price of the
Company's  Common Stock exceeds 175% of the Conversion  Price for a period of 20
consecutive  trading  days,  the Company  may  require  the  Warrant  holders to
exercise the Warrants and purchase the Warrant Notes, subject to restrictions on
the level of  exercises  that the Company may require in any period as set forth
in the Warrants. However, if the closing bid price of the Company's Common Stock
exceeds 200% of the Conversion  Price for a period of 20  consecutive  days, the
Company,  without  limitation,  may require the Warrant  holders to exercise the
Warrants  and  purchase  the  Warrant   Notes.   The  Warrant  Notes  will  have
substantially  the same terms as the Notes with a term of three years from their
date of issuance and an interest rate of 12.0% per annum, payable in cash or, at
the election of the Company, shares of Common Stock.

The Company has the right, subject to certain conditions set forth in the Notes,
to redeem the Notes,  Warrants and Warrant Notes at any one time by delivering a
cash amount equal to the outstanding principal and accrued interest of the Notes
and Warrant Notes, plus a premium of 105%-110% depending on the redemption date,
and warrants to purchase shares of the Company's  Common Stock at the Conversion
Price (the "Common Stock  Warrants").  The Company also has the right to defease
the Notes in accordance with the terms set forth in the Notes.

The Company has agreed to prepare and, on or prior to April 23, 1999,  file with
the SEC a  Registration  Statement  on Form S-3 which  covers  the resale by the
holders of the Notes and Warrants  issued on the Closing Date of (i) a number of
shares of Common  Stock  equal to at least the number of shares of Common  Stock
issuable to the holders upon  conversion of the Notes issued on the Closing Date
and the Warrant  Notes  issuable  upon  exercise of the  Warrants  issued on the
Closing Date,  determined as if such Notes and the Warrant Notes,  together with
three months' accrued and unpaid interest thereon, were converted in full at the
Conversion  Price, and (ii) such additional  number of shares of Common Stock as
the Company in its  discretion  determines  to register in  connection  with the
issuance  of the  shares of Common  Stock in payment  of  interest  on the Notes
issued on the  Closing  Date and Warrant  Notes  issuable  upon  exercise of the
Warrants  issued on the Closing  Date and the issuance of shares of Common Stock
upon exercise of any Common Stock Warrants that may be issued upon redemption of
the  Notes,  Warrants  and  Warrant  Notes.  If the  Company  does  not file the
registration statement by April 23, 1999 or if the registration statement is not
declared  effective  within  90 days  of the  Closing  Date if the  registration
statement  is not  reviewed  by the staff of the SEC or  within  135 days of the
Closing Date if the registration  statement is reviewed by the staff of the SEC,
at the Noteholders' option the Company will be obligated to redeem the Notes for
100% of their outstanding face value plus accrued and unpaid interest.

Diaz & Altschul  Capital,  LLC of New York City was the  placement  agent in the
transaction.  In consideration  for its services as placement agent, the Company
paid Diaz &  Altschul  Capital,  LLC a fee of  $1,400,000  with  respect  to the
placement  of the  $28,000,000  principal  amount of Notes issued on the Closing
Date.  Diaz & Altschul  Capital,  LLC will be entitled to additional fees in the
event the Warrants are exercised.
<PAGE>


Item 7.  Financial Statements, Pro Forma Financial Information and Exhibits.

(c)      Exhibits.

4.1      Form of Securities Purchase and Exchange  Agreement,  dated as of March
         19, 1999, by and between the Company and the investors named therein.

4.2      Form of 12% Senior Convertible Note due 2002.

4.3      Form of 12% Senior Convertible Note Purchase Warrant.

99.1     Press Release, titled "SUGEN, Inc. Announces $28.0 Million Financing by
         Private Placement of Senior Convertible Notes," dated March 22, 1999.





<PAGE>


                                   SIGNATURES
<TABLE>
Pursuant  to the  requirements  of the  Securities  Exchange  Act of  1934,  the
Registrant  has duly  caused  this  report  to be  signed  on its  behalf by the
undersigned hereunto duly authorized.
<CAPTION>


                                                     SUGEN, Inc.
<S>       <C>                                        <C>
Dated:    March 29, 1999                             By:   /s/ James L. Knighton
          ---------------                            -------------------------------------------------
                                                     James L. Knighton
                                                     Senior Vice President and Chief Financial Officer
                                                     (Principal Financial and Accounting Officer)

</TABLE>



================================================================================

                   SECURITIES PURCHASE AND EXCHANGE AGREEMENT

                           dated as of March 19, 1999


                                 by and between


                                   SUGEN, INC.


                                       and


                                     [BUYER]





                       ----------------------------------





                      12% SENIOR CONVERTIBLE NOTES DUE 2002


                                       and


                         WARRANTS TO PURCHASE ADDITIONAL
                          12% SENIOR CONVERTIBLE NOTES


                       ----------------------------------


                                Placement Agent:


                          DIAZ & ALTSCHUL CAPITAL, LLC


================================================================================


<PAGE>


                                   SUGEN, INC.

                   SECURITIES PURCHASE AND EXCHANGE AGREEMENT

                      12% SENIOR CONVERTIBLE NOTES DUE 2002

                                       and

                         WARRANTS TO PURCHASE ADDITIONAL
                          12% SENIOR CONVERTIBLE NOTES

                                TABLE OF CONTENTS


                                                                            Page
                                                                            ----

1.  DEFINITIONS................................................................1

2.  PURCHASE AND SALE..........................................................6
    (a)      Purchase..........................................................6
    (b)      Form of Payment...................................................6
    (c)      Exchange of Notes.................................................6
    (d)      Closing...........................................................7

3.  REPRESENTATIONS, WARRANTIES, COVENANTS, ETC. OF
    THE BUYER..................................................................7
    (a)      Acquisition for Investment........................................7
    (b)      Accredited Investor...............................................7
    (c)      Reoffers and Resales..............................................7
    (d)      Company Reliance..................................................8
    (e)      Information Provided..............................................8
    (f)      Absence of Approvals..............................................8
    (g)      Securities Purchase and Exchange Agreement........................8
    (h)      Buyer Status......................................................9

4.  REPRESENTATIONS, WARRANTIES, COVENANTS, ETC. OF
    THE COMPANY................................................................9
    (a)      Organization and Authority........................................9
    (b)      Qualifications....................................................9
    (c)      Capitalization....................................................9
    (d)      Material Losses..................................................10
    (e)      Concerning the Shares and the Common Stock.......................10
    (f)      Corporate Authorization..........................................10
    (g)      Non-contravention................................................11
    (h)      Approvals, Filings, Etc..........................................11
    (i)      Information Provided.............................................11
    (j)      Conduct of Business..............................................11
    (k)      SEC Filings......................................................12
    (l)      Absence of Certain Proceedings...................................12
    (m)      Liabilities......................................................12

                                    -2-

<PAGE>

    (n)      Absence of Certain Changes.......................................12
    (o)      Intellectual Property............................................12
    (p)      Internal Accounting Controls.....................................13
    (q)      Compliance with Law..............................................13
    (r)      Properties.......................................................13
    (s)      Labor Relations..................................................13
    (t)      Insurance........................................................13
    (u)      Tax Matters......................................................13
    (v)      Investment Company...............................................14
    (w)      Absence of Brokers, Finders, Etc.................................14
    (x)      No Solicitation..................................................14
    (y)      Rights Agreement.................................................14
    (z)      Certain Securities Law Matters...................................14

5.  CERTAIN COVENANTS AND WAIVER..............................................14
    (a)      Transfer Restrictions............................................14
    (b)      Restrictive Legends..............................................15
    (c)      Nasdaq Listing...................................................16
    (d)      Form D...........................................................16
    (e)      State Securities Laws............................................16
    (f)      Limitation on Certain Actions....................................16
    (g)      Use of Proceeds..................................................16
    (h)      Best Efforts.....................................................17
    (i)      Debt Obligation..................................................17
    (j)      Buyer's Waiver...................................................17

6.  CONDITIONS TO THE COMPANY'S OBLIGATION TO SELL
    AND EXCHANGE..............................................................17

7.  CONDITIONS TO THE BUYER'S OBLIGATIONS TO
    PURCHASE AND EXCHANGE.....................................................18
    (a)      Closing Date.....................................................18
    (b)      Exchange Date....................................................19

8.  REGISTRATION RIGHTS.......................................................19
    (a)      Mandatory Registration...........................................19
    (b)      Obligations of the Company.......................................20
    (c)      Obligations of the Buyer and other Investors.....................23
    (d)      Rule 144.........................................................24

9.  INDEMNIFICATION AND CONTRIBUTION..........................................24
    (a)      Indemnification..................................................24
    (b)      Contribution.....................................................26
    (c)      Other Rights.....................................................26
    10.      MISCELLANEOUS....................................................26
    (a)      Governing Law....................................................26
    (b)      Headings.........................................................26
    (c)      Severability.....................................................26
    (d)      Notices..........................................................26

                                      -3-

<PAGE>

    (e)      Counterparts.....................................................26
    (f)      Entire Agreement.................................................27
    (g)      Waiver...........................................................27
    (h)      Amendment........................................................27
    (i)      Further Assurances...............................................27
    (j)      Assignment of Certain Rights and Obligations.....................27
    (k)      Expenses.........................................................28
    (l)      Termination......................................................28
    (m)      Survival.........................................................28
    (n)      Public Statements, Press Releases, Etc...........................28
    (o)      Construction.....................................................29


ANNEXES
- -------

ANNEX I    -  Form of 12% Senior Convertible Note due 2002
ANNEX II   -  Form of 12% Senior Convertible Note Purchase Warrant
ANNEX III  -  Form of Issuing Agent  Instruction  to Be Delivered on the Closing
              Date
ANNEX IV   -  Form of  Opinion  of Cooley  Godward  LLP to Be  Delivered  on the
              Closing Date
ANNEX V    -  Form of Opinion of Lyon & Lyon LLP to Be  Delivered on the Closing
              Date
ANNEX VI   -  Form  of   Instruction  to  Transfer  Agent  to  Be  Delivered  in
              Connection with Effectiveness of the Registration Statement
ANNEX VII  -  Form  of  Opinion  of  Cooley  Godward  LLP  to  Be  Delivered  in
              Connection with Effectiveness of the Registration Statement
ANNEX VIII -  Form of Opinion of Lyon & Lyon LLP to Be Delivered  in  Connection
              with Effectiveness of the Registration Statement

                                       -4-

<PAGE>

                   SECURITIES PURCHASE AND EXCHANGE AGREEMENT




         THIS SECURITIES PURCHASE AND EXCHANGE AGREEMENT,  dated as of March 19,
1999 (this  "Agreement"),  by and between SUGEN,  INC., a Delaware  corporation,
with  headquarters  located  at 230 East  Grand  Avenue,  South  San  Francisco,
California 94080 (the "Company"), and [_________________] (the "Buyer").

                              W I T N E S S E T H:

         WHEREAS,  the Buyer wishes to purchase from the Company and the Company
wishes to sell to the Buyer,  upon the terms and  subject to the  conditions  of
this  Agreement,  the  Purchase  Note  (such  capitalized  term  and  all  other
capitalized terms used in this Agreement having the meanings provided in Section
1) having the  aggregate  principal  amount,  if any, set forth on the signature
page of this  Agreement  and which  will be  convertible  into  shares of Common
Stock;

         WHEREAS,  upon  the  terms  and  subject  to  the  conditions  of  this
Agreement,  the Company  wishes to issue the Exchange Note, if any, to the Buyer
in exchange for the  Outstanding  Note, if any, and the Buyer wishes to exchange
the Outstanding Note, if any, for the Exchange Note; and

         WHEREAS,  in connection with the issuance of the Notes,  the Company is
issuing to the Buyer Warrants on the terms provided herein;

         NOW  THEREFORE,  in  consideration  of  the  premises  and  the  mutual
covenants  contained  herein  and other  good and  valuable  consideration,  the
receipt and sufficiency of which are hereby  acknowledged,  the parties agree as
follows:

         1. DEFINITIONS.

         (a) As used in this  Agreement,  the  terms  "Agreement",  "Buyer"  and
"Company"  shall  have the  respective  meanings  assigned  to such terms in the
introductory paragraph of this Agreement.

         (b) All the  agreements or  instruments  herein defined shall mean such
agreements or instruments as the same may from time to time be  supplemented  or
amended or the terms thereof waived or modified to the extent  permitted by, and
in accordance with, the terms thereof and of this Agreement.

         (c) The  following  terms  shall  have  the  following  meanings  (such
meanings to be equally  applicable  to both the singular and plural forms of the
terms defined):

         "Blackout Period" means the period of up to 20 consecutive Trading Days
commencing  on the day  immediately  after  the date the  Company  notifies  the
Investors that they are required, pursuant to Section 8(c)(4), to suspend offers
and sales of  Registrable  Securities  as a result  of an event or  circumstance
described  in  Section  8(b)(5)(A)  during  which  period,  by

                                      -5-

<PAGE>

reason  of  Section  8(b)(5)(B),  the  Company  is not  required  to  amend  the
Registration Statement or to supplement the Prospectus.

         "Business Day" means any day other than a Saturday,  Sunday or a day on
which commercial banks in The City of New York are authorized or required by law
or executive order to remain closed.

         "Claims"  means any losses,  claims,  damages,  liabilities or expenses
(joint or several), incurred by a Person.

         "Closing  Date" means 12:00 noon, New York City time, on March 24, 1999
or such other mutually agreed to time.

         "Common Stock" means the Common Stock, par value $.01 per share, of the
Company.

         "Common  Stock  Warrants"  means the  Common  Stock  Purchase  Warrants
issuable  or issued by the Company  upon  redemption  of the Notes,  the Warrant
Notes and the Warrants.

         "Common Stock Warrant  Expiration Date" means the "Expiration  Date" as
defined in the Common Stock Warrants.

         "Conversion Price" shall have the meaning to be provided or provided in
the Notes.

         "Conversion  Shares"  means the shares of Common  Stock and the related
Preferred  Share Purchase Rights issuable upon conversion of any Note or Warrant
Note.

         "Disclosure  Schedule"  means the Disclosure  Schedule  prepared by the
Company and  furnished to the Buyer prior to the date of execution  and delivery
of this Agreement by the Buyer.

         "Event of Default" shall have the meaning to be provided or provided in
the Notes or the Warrant Notes.

         "Exchange  Date" means the date that is 135 days after the Closing Date
or such earlier date specified by the Buyer in accordance with Section 2(c)(2).

         "Exchange Note" means the 12% Senior  Convertible  Note due 2002 in the
form of Annex I to this  Agreement to be issued to the Buyer in exchange for the
Outstanding Note, if any, pursuant to Section 2(c).

         "Indemnified Party" means the Company,  each of its directors,  each of
its officers,  each Person,  if any, who controls the Company within the meaning
of the 1933 Act or the 1934  Act,  any  underwriter  and any  other  stockholder
offering or selling securities pursuant to the Registration  Statement or any of
its  directors  or  officers  or any Person who  controls  such  stockholder  or
underwriter within the meaning of the 1933 Act or the 1934 Act.

                                      -6-

<PAGE>

         "Indemnified  Person"  means  the  Buyer and each  other  Investor  who
beneficially owns or holds Registrable  Securities  included in the Registration
Statement  and each other  Investor who offers or sells  Registrable  Securities
included  in the  Registration  Statement  in the  manner  permitted  under this
Agreement,  the directors,  if any, of the Buyer or such Investor, the officers,
if any, of the Buyer and any such  Investor,  each Person,  if any, who controls
the Buyer or any such  Investor  within the  meaning of the 1933 Act or the 1934
Act,  any  underwriter  (as  defined  in the 1933  Act)  acting  on behalf of an
Investor who  participates  in the offering of  Registrable  Securities  of such
Investor  in  accordance  with  the  plan  of  distribution   contained  in  the
Prospectus, the directors, if any, of such underwriter and the officers, if any,
of such underwriter,  and each Person, if any, who controls any such underwriter
within the meaning of the 1933 Act or the 1934 Act.

         "Inspector"  means any attorney,  accountant or other agent  reasonably
acceptable to the Company  retained by an Investor for the purposes  provided in
Section 8(b)(9).

         "Interest  Shares"  means the  shares of Common  Stock and the  related
Preferred  Share Purchase Rights issuable in payment of interest on the Notes or
the Warrant Notes.

         "Investor" means the Buyer and any permitted transferee or assignee who
agrees to become bound by the provisions of Sections 5(a), 5(b), 8, 9, and 10 of
this Agreement.

         "Issuing  Agent  Instruction"  means the letter from the Company to the
Transfer Agent in the form of Annex III to this Agreement.

         "Margin  Stock" shall have the meaning  provided in Regulation U of the
Board of Governors of the Federal Reserve System (12 C.F.R. Part 221).

         "Market Price" shall have the meaning to be provided or provided in the
Notes.

         "Maturity  Date"  shall have the  meaning to be provided or provided in
the Notes.

         "Nasdaq" means the Nasdaq National Market.

         "NASD" means the National Association of Securities Dealers, Inc.

         "1997  10-K"  means the  Company's  Annual  Report on Form 10-K for the
fiscal year ended  December 31, 1997  (including  any  information  or documents
incorporated therein by reference).

         "1934 Act" means the Securities Exchange Act of 1934, as amended.

         "1933 Act" means the Securities Act of 1933, as amended.

         "Non-Responsive  Investor"  means an Investor  who does not provide the
Required  Information  to the  Company  at least one  Business  Day prior to the
filing of the Registration Statement.

                                      -7-

<PAGE>

         "Note" means the Purchase Note or the Exchange Note and "Notes"  means,
collectively, the Purchase Note and the Exchange Note.

         "Other  Notes"  means the  "Other  Notes"  and the  "Warrant  Notes" as
defined in the Notes.

         "Other Securities  Purchase  Agreements"  means the several  Securities
Purchase and Exchange  Agreements,  dated as of the date hereof,  by and between
the Company and the buyers named therein relating to the Other Notes.

         "Outstanding  Note"  means  all  of  the  Company's  5%  Senior  Custom
Convertible Notes due 2000 registered in the name of the Buyer or its nominee.

         "Person" means any natural person,  corporation,  partnership,  limited
liability company, trust, incorporated organization, unincorporated association,
or  similar  entity  or  any  government,   governmental   agency  or  political
subdivision.

         "Placement Agent" means Diaz & Altschul Capital, LLC.

         "Preferred  Share Purchase  Rights" means the Preferred  Share Purchase
Rights  issued or  issuable  pursuant  to the Rights  Agreement  (or any similar
rights hereafter issued by the Company with respect to the Common Stock).

         "Prospectus"  means the  prospectus  forming  part of the  Registration
Statement at the time the Registration  Statement is declared  effective and any
amendment or  supplement  thereto and  including  any  documents or  information
incorporated therein by reference.

         "Purchase Note" means the 12% Senior  Convertible  Note due 2002 of the
Company in the form of Annex I to this  Agreement  to be  purchased by the Buyer
pursuant to Section 2(a).

         "Purchase  Price"  means the purchase  price for the Purchase  Note set
forth on the signature page of this Agreement.

         "Questionnaire" means the Prospective Purchaser Questionnaire completed
by the Buyer in connection with this Agreement.

         "QIB" means a "qualified institutional buyer" as defined in Rule 144A.

         "Record"  means all pertinent  financial and other  records,  pertinent
corporate  documents and properties of the Company subject to inspection for the
purposes provided in Section 8(b)(9).

         "Register,"  "registered," and  "registration"  refer to a registration
effected by preparing  and filing the  Registration  Statement or  Statements in
compliance  with the 1933 Act and pursuant to Rule 415, and the  declaration  or
ordering of effectiveness of such Registration Statement by the SEC.

         "Registrable  Securities"  means the Shares (other than the  Conversion
Shares  issuable upon conversion of, and the Interest Shares issuable in payment
of interest on, the

                                      -8-

<PAGE>

Exchange  Notes) and any stock or other  securities  into which or for which the
Common Stock may hereafter be changed,  converted or exchanged by the Company or
its successor, as the case may be, and any other securities issued to holders of
such Common Stock (or such stock or other securities into which or for which the
shares are so changed, converted or exchanged) upon any reclassification,  share
combination, share subdivision, share dividend, merger, consolidation or similar
transaction or event.

         "Registration  Period" means the period from the SEC Effective  Date to
the earlier of

         (i) the date  which is two years  after the later of (A) the end of the
Warrant Exercise Period and (B) the Common Stock Warrant Expiration Date (or, if
(x) the Notes and the Warrant Notes shall have been fully  converted into shares
of Common Stock and the Warrants and the Common Stock  Warrants  shall have been
fully exercised,  (y) the Maturity Date of the Notes and the Warrant Notes shall
have occurred,  the Common Stock Warrant Expiration Date shall have occurred and
the Warrant  Exercise  Period shall have  expired or (z) the Notes,  the Warrant
Notes,  the  Warrants  and the  Common  Stock  Warrants  shall no longer  remain
outstanding, such date after which each Investor may sell all of its Registrable
Securities without registration under the 1933 Act pursuant to Rule 144, free of
any  limitation  on the  volume  of  such  securities  which  may be sold in any
period), and

         (ii) the date on which the  Investors  no longer  beneficially  own any
Registrable Securities.

         "Registration Statement" means a registration statement on Form S-3 (or
the comparable form at the time of filing with the SEC) of the Company under the
1933 Act relating to the resale of the  Registrable  Securities  and which names
the Investors as selling stockholders.

         "Regulation D" means Regulation D under the 1933 Act.

         "Repurchase Event" shall have the meaning to be provided or provided in
the Notes or the Warrant Notes.

         "Required  Information"  means,  with  respect  to  any  Investor,  all
information  regarding such Investor,  the  Registrable  Securities held by such
Investor or which such Investor has the right to acquire and the intended method
of disposition of the Registrable Securities held by such Investor or which such
Investor has the right to acquire as shall be required by the 1933 Act to effect
the registration of the resale by such Investor of such Registrable Securities.

         "Rights  Agreement" means the Rights  Agreement,  dated as of August 1,
1995, by and between the Company and Boston EquiServe, as Rights Agent.

         "Rule  415"  means  Rule 415 under the 1933 Act or any  successor  rule
providing for offering securities on a delayed or continuous basis.

         "Rule 144" means Rule 144 under the 1933 Act or any other  similar rule
or regulation of the SEC that may at any time provide a "safe harbor"  exemption
from registration  under the 1933 Act so as to permit a holder of any securities
to sell securities of the Company to the public without  registration  under the
1933 Act.

                                      -9-

<PAGE>

         "Rule  144A" means Rule 144A under the 1933 Act or any  successor  rule
thereto.

         "SEC" means the Securities and Exchange Commission.

         "SEC  Effective  Date"  means the date the  Registration  Statement  is
declared effective by the SEC.

         "SEC Filing  Date" means the date the  Registration  Statement is first
filed with the SEC pursuant to Section 8.

         "SEC Reports"  means (1) the 1997 10-K,  (2) the  Company's  definitive
Proxy  Statement  for its  1998  Annual  Meeting  of  Stockholders,  and (3) the
Company's  Quarterly  Reports on Form 10-Q for the quarters ended March 31, June
30, and September 30, 1998, in each case as filed with the SEC and including the
information  and  documents  (other  than  exhibits)   incorporated  therein  by
reference.

         "Securities"  means,  collectively,  the Notes,  the Warrant Notes, the
Warrants, the Common Stock Warrants, and the Shares.

         "September 1998 10-Q" means the Company's Quarterly Report on Form 10-Q
for the quarter ended September 30, 1998, as filed with the SEC.

         "Shares"  means the  Conversion  Shares,  the  Interest  Shares and the
Warrant Shares.

         "Subsidiary"  means any corporation or other entity of which a majority
of the capital stock or other ownership  interests  having ordinary voting power
to elect a  majority  of the  board of  directors  or other  persons  performing
similar functions are at the time directly or indirectly owned by the Company.

         "Trading  Day" shall have the meaning to be provided or provided in the
Notes.

         "Transaction  Documents"  means,  collectively,   this  Agreement,  the
Securities  and the other  agreements,  instruments  and documents  contemplated
hereby and thereby.

         "Transfer  Agent" means  BankBoston,  N.A., or any  successor  thereof,
serving as transfer agent and registrar for the Common Stock.

         "Violation" means

         (i) any untrue statement or alleged untrue statement of a material fact
contained in the Registration Statement or any post-effective  amendment thereof
or the omission or alleged omission to state therein a material fact required to
be stated therein or necessary to make the statements therein not misleading,

         (ii) any untrue  statement  or alleged  untrue  statement of a material
fact  contained in the Prospectus  (as amended or  supplemented,  if the Company
files any amendment thereof or supplement  thereto with the SEC) or the omission
or alleged  omission to state  therein any material  fact  necessary to make the
statements  made  therein,  in  light  of  the  circumstances  under  which  the
statements therein were made, not misleading,

                                      -10-

<PAGE>

         (iii) any  violation  or alleged  violation  by the Company of the 1933
Act, the 1934 Act, any state  securities law or any rule or regulation under the
1933 Act, the 1934 Act or any state securities law, or

         (iv) any breach or alleged breach by any Person other than the Buyer of
any representation,  warranty,  covenant,  agreement or other term of any of the
Transaction Documents.

         "Warrant Exercise Period" means the "Exercise Period" as defined in the
Warrants.

         "Warrants" means the 12% Senior  Convertible Note Purchase  Warrants in
the form of Annex II to this Agreement.

         "Warrant  Note"  means any 12% Senior  Convertible  Note in the form of
Exhibit 3 to the  Warrants in the  aggregate  principal  amount set forth on the
signature  page of this  Agreement  that is  issuable  or  issued  to the  Buyer
pursuant to the Warrant.

         "Warrant  Shares"  means the  shares of  Common  Stock and the  related
Preferred  Share  Purchase  Rights  issuable  upon  exercise of the Common Stock
Warrants.

         2. PURCHASE AND SALE; PURCHASE PRICE; EXCHANGE.

         (a)  Purchase.  Upon the terms and  subject to the  conditions  of this
Agreement, the Buyer hereby agrees to purchase from the Company, and the Company
hereby agrees to sell to the Buyer,  on the Closing  Date,  the Purchase Note in
the  principal  amount set forth on the  signature  page of this  Agreement  and
having the terms and  conditions  as set forth in the form of the Note  attached
hereto as Annex I for the Purchase  Price.  In connection  with the purchase and
sale of the  Purchase  Note,  the  Company  will issue to the Buyer a Warrant to
purchase Warrants Notes having an aggregate principal amount equal to 75 percent
of the original principal amount the Purchase Note.

         (b) Form of Payment.  Payment by the Buyer of the  Purchase  Price,  if
any, to the Company on the Closing Date shall be made by wire  transfer of funds
to:

         Citibank, N.A.
         111 Wall Street
         New York, New York
         ABA No. 021000089

         For credit to the account of Morgan, Stanley & Co.
         Account No. 3889-0774
         For further credit to the account of SUGEN, Inc.
         Account No. 14-78177
         Reference:  NP

         (c) Exchange of Notes. (1) Upon the terms and subject to the conditions
of this  Agreement,  the Buyer  hereby  agrees to deliver to the  Company on the
Exchange  Date the  Outstanding  Note,  if any,  and the  Company  agrees (x) to
deliver to the Buyer or its  designee on the  Exchange  Date in exchange for the
Outstanding Note, if any, an Exchange Note in the

                                      -11-

<PAGE>

principal amount determined as stated opposite the heading Exchange Ratio on the
signature page of this Agreement and a Warrant to purchase  Warrant Notes having
an aggregate  principal  amount  equal to 75 percent of the  original  principal
amount of the  Exchange  Note and (y) to pay the Buyer on the  Exchange  Date by
wire transfer of  immediately  available  funds to the account  specified by the
Buyer an  amount  in cash  equal  to the  accrued  and  unpaid  interest  on the
Outstanding Note, if any, to the Exchange Date. The Company agrees to cancel the
Outstanding  Note in full  immediately  after  such  exchange.  Nothing  in this
Agreement shall limit the right of the Buyer to convert the Outstanding  Note in
accordance with the terms thereof at any time prior to the Exchange Date.

         (2) At any time on or after the Closing Date and prior to the date that
is 135 days after the Closing Date, the Buyer shall have the right,  exercisable
by notice  given to the Company,  to specify an Exchange  Date which is prior to
the date that is 135 days after the Closing  Date,  but not  earlier  than three
Trading  Days after the Buyer gives such  notice.  If the Buyer shall have given
such notice and stated in such  notice  that the Buyer is waiving the  condition
precedent in Section 7(b)(4),  then the Buyer may specify that the Exchange Date
shall be on the date that the Buyer gives such  notice,  in which case the Buyer
shall be deemed to have become the holder of the  Exchange  Note on the date the
Buyer gives such notice; provided, however, that the Buyer shall not be entitled
to exercise any of the rights of a holder of the  Exchange  Note until the Buyer
surrenders the Outstanding Note to the Company.

         (3) If the  conditions  precedent in Section 7(b) are not  satisfied or
waived by the Buyer on an Exchange Date that is on or prior to the date which is
135 days after the Closing  Date,  then neither the Buyer nor the Company  shall
have any further  obligation to exchange the  Outstanding  Note for the Exchange
Note but each of the Buyer and the Company shall remain liable for any breach of
its obligations under the Transaction Documents with respect thereto.

         (d)  Closing.  The  issuance  and  sale of the  Purchase  Note  and the
issuance of the Warrant  referred to in Section  2(a) shall occur on the Closing
Date at the Law Offices of Brian W Pusch,  Penthouse Suite, 29 West 57th Street,
New York, New York. At the closing, upon the terms and subject to the conditions
of this Agreement, the Company shall issue and deliver to the Buyer the Purchase
Note and such Warrant  against  payment by the Buyer to the Company of an amount
equal to the  Purchase  Price,  and the Buyer shall pay to the Company an amount
equal to the  Purchase  Price  against  delivery of the  Purchase  Note and such
Warrant to the Buyer.

         3. REPRESENTATIONS, WARRANTIES, COVENANTS, ETC. OF THE BUYER.

         The Buyer  represents  and warrants to, and  covenants and agrees with,
the Company as follows:

         (a) Acquisition  for  Investment.  The Buyer is acquiring the Notes and
the Warrant and will acquire the Warrant  Notes,  the Common Stock  Warrants and
the  Warrant  Shares  for its own  account  for  investment  and not with a view
towards the public sale or  distribution  thereof within the meaning of the 1933
Act;  the Buyer will  acquire  any Shares  issued to the Buyer  prior to the SEC
Effective Date of the Registration  Statement covering the resale of such Shares
by the Buyer for its own account for  investment and not with a view

                                      -12-

<PAGE>

towards the public sale or  distribution  thereof within the meaning of the 1933
Act prior to the SEC  Effective  Date;  and the Buyer has no intention of making
any  distribution,  within the meaning of the 1933 Act, of the Shares  except in
compliance with the registration  requirements of the 1933 Act or pursuant to an
exemption therefrom;  provided,  however, that by making this representation the
Buyer does not agree to hold the securities for any minimum or specified  period
of time  (unless  any such  holding  period is required by the terms of any such
exemption being relied on by the Buyer).

         (b) Accredited Investor.  The Buyer is an "accredited investor" as that
term is defined in Rule 501 of Regulation D under the 1933 Act by reason of Rule
501(a)(3) thereof;

         (c) Reoffers and Resales.  The Buyer will not,  directly or indirectly,
offer, sell, pledge,  transfer or otherwise dispose of (or solicit any offers to
buy,  purchase or otherwise  acquire or take a pledge of) any of the  Securities
unless registered under the 1933 Act, pursuant to an exemption from registration
under the 1933 Act or in a transaction not requiring registration under the 1933
Act;

         (d)  Company  Reliance.  The Buyer  understands  that (1) the Notes are
being  offered and sold and the Warrants are being issued to the Buyer,  (2) the
Shares, the Warrant Notes and the Common Stock Warrants are being offered to the
Buyer, (3) upon conversion of the Notes, the Conversion Shares will be issued to
the Buyer,  (4) upon exercise of the Warrants,  the Warrant Notes will be issued
to the Buyer, (5) upon any redemption of the Notes and the Warrants,  the Common
Stock  Warrants  will be issued to the Buyer,  (6) upon  exercise  of the Common
Stock  Warrants,  the Warrant  Shares  will be issued to the Buyer,  and (7) the
Interest  Shares  will be issued to the Buyer,  in each such case in reliance on
one or more  exemptions  from the  registration  requirements  of the 1933  Act,
including,   without  limitation,   Regulation  D,  and  exemptions  from  state
securities  laws and that the Company is relying upon the truth and accuracy of,
and the Buyer's compliance with, the  representations,  warranties,  agreements,
acknowledgments  and  understandings  of the Buyer set forth  herein  and in the
Questionnaire, a true and accurate copy of which has been delivered by the Buyer
to the Company,  in order to determine the  availability  of such exemptions and
the  eligibility  of the Buyer to acquire  or  receive  an offer to acquire  the
Securities;  and the  information  with  respect  to the  Buyer set forth in the
Questionnaire is accurate and complete in all material respects;

         (e)  Information  Provided.  The Buyer and its  advisors,  if any, have
requested,  received and  considered all  information  relating to the business,
properties, operations, condition (financial or other), results of operations or
prospects of the Company and  information  relating to the offer and sale of the
Notes and  issuance of the  Warrants,  and the offer of the Warrant  Notes,  the
Conversion  Shares,  the Common Stock  Warrants,  and the Warrant  Shares deemed
relevant by them (assuming the accuracy and  completeness of the SEC Reports and
of the Company's responses to the Buyer's requests); the Buyer and its advisors,
if any,  have been  afforded  the  opportunity  to ask  questions of the Company
concerning  the  terms  of the  offering  of the  Securities  and the  business,
properties,  operations,  condition (financial or other),  results of operations
and prospects of the Company and have received  satisfactory answers to any such
inquiries  (assuming  the accuracy and  completeness  of the SEC Reports and the
Company's responses to the Buyer's requests); without limiting the generality of
the foregoing, the Buyer has had the opportunity to obtain and to review the SEC
Reports and the Disclosure Schedule; in connection with its decision to purchase
the Notes and to acquire the Warrants,  the Buyer has relied solely upon the SEC
Reports, the Disclosure 

                                      -13-

<PAGE>

Schedule,  the  representations,  warranties,  covenants  and  agreements of the
Company set forth in this Agreement and to be contained in the other Transaction
Documents, as well as any investigation of the Company completed by the Buyer or
its  advisors,  if  any;  the  Buyer  understands  that  its  investment  in the
Securities  involves a high degree of risk; and the Buyer  understands  that the
offering of the Notes and the  Warrants is being made to the Buyer as part of an
offering  without  any  minimum  or  maximum  amount of the  offering  (subject,
however, to the right of the Company at any time prior to execution and delivery
of this Agreement by the Company, in its sole discretion, to accept or reject an
offer by the Buyer to purchase the Notes and to acquire the Warrants);

         (f) Absence of Approvals.  The Buyer  understands that no United States
federal  or state  agency or any other  government  or  governmental  agency has
passed on or made any recommendation or endorsement of the Securities;

         (g)  Securities  Purchase  and  Exchange  Agreement.  The Buyer has all
requisite power and authority,  corporate or otherwise, to execute,  deliver and
perform its obligations  under this Agreement and the other agreements  executed
by  the  Buyer  in  connection  herewith  and  to  consummate  the  transactions
contemplated  hereby and thereby;  and this  Agreement has been duly and validly
authorized, duly executed and delivered by the Buyer and, assuming due execution
and  delivery  by the  Company,  is a valid and binding  agreement  of the Buyer
enforceable in accordance with its terms,  except as the  enforceability  hereof
may be limited by bankruptcy, insolvency, reorganization, moratorium, fraudulent
conveyance  or other  similar  laws now or  hereafter  in effect  relating to or
affecting   creditors'  rights  generally  and  general  principles  of  equity,
regardless of whether  enforcement is considered in a proceeding in equity or at
law; and

         (h) Buyer  Status.  The Buyer is not a "broker"  or  "dealer"  as those
terms are defined in the 1934 Act which is required  to be  registered  with the
SEC pursuant to Section 15 of the 1934 Act.

         4. REPRESENTATIONS, WARRANTIES, COVENANTS, ETC. OF THE COMPANY.

         The Company  represents  and  warrants to the Buyer that the  following
matters  are true and  correct on the date of  execution  and  delivery  of this
Agreement,  will be true and  correct  on the  Closing  Date and,  to the extent
stated in Section  7(b) will be true and correct on the Exchange  Date,  and the
Company covenants and agrees with the Buyer as follows:

         (a)  Organization  and  Authority.  The Company is a  corporation  duly
organized,  validly existing and in good standing under the laws of the State of
Delaware,  and has all requisite corporate power and authority (i) to own, lease
and operate its  properties and to carry on its business as described in the SEC
Reports and as currently conducted, and (ii) to execute, deliver and perform its
obligations  under this  Agreement  and the other  Transaction  Documents  being
executed and delivered by the Company in connection herewith,  and to consummate
the  transactions   contemplated   hereby  and  thereby.   The  Company  has  no
Subsidiaries except as set forth on Schedule 4(a).

         (b)  Qualifications.  The Company is duly qualified to do business as a
foreign  corporation  and is in good  standing in all  jurisdictions  where such
qualification is

                                      -14-

<PAGE>

necessary and where failure so to qualify could have a material  adverse  effect
on the business, properties, operations, condition (financial or other), results
of operations or prospects of the Company.

         (c) Capitalization.  (1) The authorized capital of the Company consists
of (a)  30,000,000  shares of Common  Stock,  of which  16,734,113  shares  were
outstanding at the close of business on March 10, 1999 and (b) 20,000,000 shares
of Preferred Stock, $.01 par value, of which 300,000 shares have been designated
Series A Junior  Participating  Preferred  Stock,  none of which is outstanding;
from March 10, 1999 to the Closing  Date there will be (x) no material  increase
in the number of shares of Common Stock outstanding (except for shares of Common
Stock  issued  upon  exercise of options and  warrants  outstanding  on the date
hereof or options  or  similar  rights  granted  subsequent  to the date of this
Agreement  pursuant to the Company's stock option plans in effect on the date of
this  Agreement and except for shares of Common Stock issued upon  conversion or
in payment of interest on the Company's 5% Senior Custom  Convertible  Notes due
2002 that are  outstanding on the date of this Agreement) and (y) no issuance of
securities convertible into, exchangeable for, or otherwise entitling the holder
to acquire, shares of Common Stock (except for securities issued pursuant to the
Other  Securities  Purchase  Agreements and except for Preferred  Share Purchase
Rights issuable in connection with the issuance of shares of Common Stock issued
in  accordance  with the  immediately  preceding  clause  (x)).  The  1997  10-K
discloses  as of December 31, 1997 all  outstanding  options or warrants for the
purchase  of, or other  rights to  purchase  or  subscribe  for,  or  securities
convertible into or exchangeable for, Common Stock or other capital stock of the
Company,  or any contracts or commitments to issue or sell Common Stock or other
capital  stock of the  Company or any such  options,  warrants,  rights or other
securities; and from December 31, 1997 to the date hereof there has been, and to
the Closing Date there will be, no material change in the amount or terms of any
of the  foregoing  except for the grant of options to purchase  shares of Common
Stock pursuant to the Company's stock option plans in effect on the date of this
Agreement and except as disclosed in the SEC Reports.

         (2) The Company has duly  reserved  from its  authorized  and  unissued
shares of Common  Stock the full number of shares  required for (A) all options,
warrants,  convertible  securities  and other rights to acquire shares of Common
Stock which are  outstanding  and (B) all shares of Common Stock and options and
other  rights to acquire  shares of Common  Stock which may be issued or granted
under the stock option and similar  plans which have been adopted by the Company
or any Subsidiary;  and,  immediately  following the Closing Date,  after giving
effect to any antidilution or similar  adjustment  arising by reason of issuance
of the Notes and the Other Notes and the other transactions contemplated by this
Agreement,  the total number of shares of Common Stock  reserved and required to
be reserved from the authorized and unissued shares of Common Stock for purposes
of all such options,  warrants,  convertible securities,  other rights and stock
option and similar plans  (excluding the Notes and the Other Notes and the other
transactions  contemplated by this Agreement) will be 5,729,664. No antidilution
adjustment  will  occur  with  respect  to any  outstanding  class or  series of
securities  of the Company by reason of issuance,  conversion or exercise of the
Securities or the other  transactions  contemplated by this Agreement  except as
set forth on Schedule 4(c) of the Disclosure Schedule. The outstanding shares of
capital stock of the Company have been duly  authorized  and validly  issued and
are fully paid and  nonassessable  and all of such  options,  warrants and other
rights have been duly  authorized  by the  Company.  None of the holders of such
outstanding  shares of capital stock is subject to personal  liability solely by
reason of being such a holder.  None of the outstanding  shares of capital stock
and options,  warrants and other

                                      -15-

<PAGE>

rights to acquire  Common Stock has been issued in  violation of the  preemptive
rights  of any  security  holder of the  Company.  The  offers  and sales of the
outstanding  shares of capital  stock of the Company and  options,  warrants and
other  rights  to  acquire  Common  Stock  were  at all  relevant  times  either
registered  under the 1933 Act and applicable  state  securities  laws or exempt
from such  requirements.  No holder of any of the Company's  securities  has any
rights,  "demand," "piggy-back" or otherwise, to have such securities registered
by reason of the intention to file,  filing or effectiveness of the Registration
Statement.

         (d) Material Losses. Since the date as of which information is given in
the 1997 10-K or the September 1998 10-Q, neither the Company nor any Subsidiary
has sustained  any loss or  interference  with its business or  properties  from
fire, flood,  hurricane,  accident or other calamity,  whether or not covered by
insurance,  or from any labor dispute or court or governmental  action, order or
decree,   which  loss  or  interference  would  be  material  to  the  business,
properties, operations, condition (financial or other), results of operations or
prospects of the Company and the Subsidiaries, taken as a whole.

         (e)  Concerning  the Shares and the Common Stock.  The Shares have been
duly  authorized and the Conversion  Shares,  when issued upon conversion of the
Notes and the Warrant  Notes,  the  Interest  Shares,  when issued in payment of
interest on the Notes and the Warrant Notes, and the Warrant Shares, when issued
upon exercise of the Common Stock  Warrants,  in each such case will be duly and
validly issued,  fully paid and  non-assessable  and will not subject the holder
thereof to personal  liability  by reason of being such  holder.  The holders of
outstanding  shares  of  capital  stock  of the  Company  are  not  entitled  to
preemptive or other rights to subscribe for the Securities. The Company has duly
reserved  4,750,000  shares of Common Stock for issuance upon  conversion of the
Notes,  the Warrant  Notes and the Other Notes and  exercise of the Common Stock
Warrants,  and such shares shall remain so reserved,  and the Company shall from
time to time reserve such additional shares of Common Stock as shall be required
to be reserved  pursuant to the Notes, the Warrants,  the Warrant Notes, and the
Common  Stock  Warrants  as  long as the  Notes  and the  Warrant  Notes  may be
converted or the Warrants and the Common Stock  Warrants may be  exercised.  The
Common  Stock is listed for trading on Nasdaq and (1) the Company and the Common
Stock meet the criteria  for  continued  listing and trading on Nasdaq;  (2) the
Company has not been  notified  since  January 1, 1996 by the NASD or the Nasdaq
Stock  Market of any  failure  or  potential  failure to meet the  criteria  for
continued  listing and trading on Nasdaq and (3) no suspension of trading in the
Common Stock is in effect.  The Company  knows of no reason that the Shares will
not be eligible for listing on Nasdaq.

         (f) Corporate  Authorization.  This Agreement and the other Transaction
Documents have been duly and validly  authorized by the Company;  this Agreement
has been duly executed and delivered by the Company and,  assuming due execution
and delivery by the Buyer, this Agreement is, and the Notes, the Warrants,  each
Warrant Note and the Common Stock  Warrants will be, when executed and delivered
by the Company,  valid and binding  obligations  of the Company  enforceable  in
accordance with their respective terms, except as the enforceability thereof may
be limited by bankruptcy,  insolvency,  reorganization,  moratorium,  fraudulent
conveyance  or other  similar  laws now or  hereafter  in effect  relating to or
affecting   creditors'  rights  generally  and  general  principles  of  equity,
regardless of whether  enforcement is considered in a proceeding in equity or at
law.

                                      -16-
<PAGE>

         (g)  Non-contravention.  The execution and delivery of the  Transaction
Documents by the Company and the consummation by the Company of the transactions
contemplated by the  Transaction  Documents do not and will not, with or without
the giving of notice or the lapse of time, or both,  (i) result in any violation
of any  provision  of the  certificate  of  incorporation  or by-laws or similar
instruments of the Company or any Subsidiary,  (ii) conflict with or result in a
breach by the Company or any Subsidiary of any of the terms or provisions of, or
constitute a default under, or result in the  modification  of, or result in the
creation or imposition of any lien,  security  interest,  charge or  encumbrance
upon any of the properties or assets of the Company  pursuant to, any indenture,
mortgage, deed of trust or other agreement or instrument to which the Company or
any  Subsidiary  is a party or by which the Company or any  Subsidiary or any of
their  respective  properties or assets are bound or affected which would have a
material  adverse  effect on the  business,  properties,  operations,  condition
(financial or other),  results of operations or prospects of the Company and the
Subsidiaries,  taken as a whole, (iii) violate or contravene any applicable law,
rule or regulation  or any  applicable  decree,  judgment or order of any court,
United States federal or state regulatory body,  administrative  agency or other
governmental body having  jurisdiction over the Company or any Subsidiary or any
of their  respective  properties  or assets which would have a material  adverse
effect on the business, properties,  operations, condition (financial or other),
results of operations or prospects of the Company and the Subsidiaries, taken as
a whole, or (iv) have any material adverse effect on any permit,  certification,
registration,  approval, consent, license or franchise necessary for the Company
or any  Subsidiary  to own or lease and  operate  any of its  properties  and to
conduct any of its business or the ability of the Company or any  Subsidiary  to
make use thereof.

         (h) Approvals, Filings, Etc. No authorization,  approval or consent of,
or filing with, any court, governmental body, regulatory agency, self-regulatory
organization,  or stock exchange or market or the stockholders of the Company is
required to be obtained or made by the Company or any  Subsidiary  in connection
with the execution,  delivery and performance of the  Transaction  Documents and
the issuance  and sale of the  Securities  as  contemplated  by the  Transaction
Documents,  other than (1) listing of the Shares on Nasdaq,  (2) registration of
the resale of the Shares under the 1933 Act as contemplated by Section 8, (3) as
may be required under  applicable  state  securities or "blue sky" laws, and (4)
filing of one or more Forms D with respect to the  Securities as required  under
Regulation D.

         (i) Information  Provided.  The written  information  provided by or on
behalf of the  Company  to the Buyer and  referred  to in  Section  3(e) of this
Agreement  does not contain any untrue  statement of a material  fact or omit to
state any material fact  necessary in order to make the statements  therein,  in
the light of the  circumstances  under which they are made, not  misleading,  it
being understood that for purposes of this Section 4(i), any statement contained
in such information shall be deemed to be modified or superseded for purposes of
this Section  4(i) to the extent that a statement  in any  document  included in
such  information  which  was  prepared  or filed  with the SEC on a later  date
modifies or replaces such statement, whether or not such later prepared or filed
statement so states.

         (j) Conduct of Business.  Except as set forth in the SEC Reports, since
December 31, 1997,  neither the Company nor any  Subsidiary has (i) incurred any
material  obligation  or liability  (absolute or  contingent)  other than in the
ordinary  course of  business;  (ii)  canceled,  without  payment  in full,  any
material notes,  loans or other obligations  receivable or other debts or claims
held by it other than in the ordinary course of business;  (iii) sold, 

                                      -17-
<PAGE>

assigned, transferred, abandoned, mortgaged, pledged or subjected to lien any of
its material  properties,  tangible or intangible,  or rights under any material
contract,  permit,  license,  franchise or other  agreement;  (iv) conducted its
business in a manner materially different from its business as conducted on such
date;  (v) declared,  made or paid or set aside for payment any cash or non-cash
distribution on any shares of its capital stock; or (vi) consummated, or entered
into any  agreement  with  respect  to, any  transaction  or event  which  would
constitute a  Repurchase  Event.  Except as  disclosed  in the SEC Reports,  the
Company and each Subsidiary  owns,  possesses or has obtained all  governmental,
administrative and third party licenses, permits,  certificates,  registrations,
approvals,  consents and other authorizations  necessary to own or lease (as the
case may be) and operate its properties,  whether tangible or intangible, and to
conduct its business or operations as currently conducted, except such licenses,
permits, certificates, registrations, approvals, consents and authorizations the
failure  of which to obtain  would  not have a  material  adverse  effect on the
business,  properties,  operations,  condition (financial or other),  results of
operations or prospects of the Company and the Subsidiaries, taken as a whole.

         (k) SEC Filings.  The Company has timely filed all reports  required to
be filed under the 1934 Act and any other material reports or documents required
to be filed  with  the SEC  since  January  1,  1997.  All of such  reports  and
documents  complied,  when filed, in all material respects,  with all applicable
requirements  of  the  1933  Act  and  the  1934  Act.  The  Company  meets  the
requirements  for the use of Form S-3 for the  registration of the resale of the
Registrable  Securities by the Buyer and any other Investor. The Company has not
filed any reports with the SEC under the 1934 Act since  December 31, 1997 other
than the SEC Reports.

         (l)  Absence of Certain  Proceedings.  Except as  disclosed  in the SEC
Reports, there is no action, suit,  proceeding,  inquiry or investigation before
or by any court, public board or body, or governmental agency pending or, to the
knowledge of the Company and the Subsidiaries,  threatened  against or affecting
the Company or any Subsidiary wherein an unfavorable decision, ruling or finding
would have a material  adverse effect on the business,  properties,  operations,
condition  (financial  or other),  results of  operations  or  prospects  of the
Company and the Subsidiaries, taken as a whole, or the transactions contemplated
by the  Transaction  Documents or which could  adversely  affect the validity or
enforceability  of, or the  authority  or ability of the  Company to perform its
obligations under, the Transaction Documents;  the Company does not have pending
before the SEC any request for confidential treatment of information and, to the
best of the  Company's  knowledge,  no such  request will be made by the Company
prior to the SEC  Effective  Date  except as set forth in  Schedule  4(l) of the
Disclosure  Schedule;  and to the best of the Company's  knowledge  there is not
pending or  contemplated  any, and there has been no,  investigation  by the SEC
involving the Company or any current director or officer of the Company.

         (m) Liabilities.  Except as and to the extent  disclosed,  reflected or
reserved  against  in the  financial  statements  of the  Company  and the notes
thereto included in the SEC Reports,  neither the Company nor any Subsidiary has
any material  (individually or in the aggregate) liability,  debt or obligation,
whether accrued, absolute, contingent or otherwise, and whether due or to become
due. Subsequent to December 31, 1997, neither the Company nor any Subsidiary has
incurred any  liabilities,  debts or obligations of any nature  whatsoever which
are  individually  or  in  the  aggregate   material  to  the  Company  and  the
Subsidiaries, taken as a

                                      -18-
<PAGE>

whole,  other than those incurred in the ordinary  course of its business and as
set forth in the SEC Reports.

         (n) Absence of Certain Changes. Since December 31, 1997, there has been
no material adverse change in the business,  properties,  operations,  condition
(financial  or other),  results of operations  or, to the best  knowledge of the
Company and the  Subsidiaries,  prospects  of the Company and the  Subsidiaries,
taken as a whole, except as disclosed in the SEC Reports.

         (o) Intellectual Property. Except as disclosed in the SEC Reports, each
of the Company and each  Subsidiary  (1) to the knowledge of the Company and the
Subsidiaries  after reasonable  investigation for the purposes hereof,  owns, or
possesses adequate rights to use, all patents, patent rights, inventions,  trade
secrets, know-how,  proprietary techniques,  including processes and substances,
trademarks,  service marks, trade names and copyrights  described or referred to
in the SEC Reports or owned or used by it or which are necessary for the conduct
of its  business,  except for failure to own or possess any such rights as would
not  individually  or in the  aggregate  have a material  adverse  effect on the
business,  properties,  operations,  condition (financial or other),  results of
operations or prospects of the Company and the  Subsidiaries,  taken as a whole,
and (2) has no  reason  to  believe,  and is not  aware of any  claim,  that the
conduct of its  business  will  conflict  with any such  rights of others  which
conflict or claim is material to the business, properties, operations, condition
(financial or other),  results of operations or prospects of the Company and the
Subsidiaries, taken as a whole.

         (p) Internal  Accounting  Controls.  The Company  maintains a system of
internal accounting controls meeting the requirements of Section 13(b)(2) of the
1934 Act in all material respects.

         (q)  Compliance  with Law. To the best knowledge of the Company and the
Subsidiaries,  neither the Company nor any  Subsidiary is in violation of or has
any liability under any statute, law, rule, regulation,  ordinance,  decision or
order of any  governmental  agency or body or any court,  domestic  or  foreign,
including, without limitation,  those relating to the use, operation,  handling,
transportation,  disposal or release of hazardous or toxic  substances or wastes
or  relating  to the  protection  or  restoration  of the  environment  or human
exposure to hazardous or toxic substances or wastes, except where such violation
or liability would not  individually or in the aggregate have a material adverse
effect on the business, properties,  operations, condition (financial or other),
results of operations or prospects of the Company and the Subsidiaries, taken as
a whole;  and the  Company  and the  Subsidiaries  are not aware of any  pending
investigation which would reasonably be expected to lead to such a claim.

         (r) Properties.  Except as disclosed in Schedule 4(r) of the Disclosure
Schedule,  the Company and each  Subsidiary  has good title to all property real
and personal  (tangible and  intangible)  and other assets owned by it which are
individually or in the aggregate  material to the Company and the  Subsidiaries,
taken as a whole, free and clear of all security interests,  charges, mortgages,
liens or other encumbrances,  except such as are described in the SEC Reports or
such as do not  materially  interfere  with the use of such  property  made,  or
proposed to be made, by the Company and the Subsidiaries.  To the best knowledge
of the Company and the Subsidiaries,  the leases, licenses or other contracts or
instruments  under  which the Company and each  Subsidiary  leases,  holds or is
entitled to use any property,  real or personal,  which  individually  or in the
aggregate  are material to the Company and the  

                                      -19-
<PAGE>

Subsidiaries,  taken as a whole, are valid, subsisting and enforceable with only
such  exceptions as do not  materially  interfere  with the use of such property
made,  or proposed to be made by the Company and the  Subsidiaries.  Neither the
Company nor any Subsidiary has received notice of any material  violation of any
applicable  law,  ordinance,  regulation,  order or requirement  relating to its
owned or leased properties.

         (s) Labor  Relations.  No  material  labor  problem  exists  or, to the
knowledge of the Company and the  Subsidiaries,  is imminent with respect to any
of the employees of the Company or any Subsidiary.

         (t)  Insurance.  The Company and each  Subsidiary  maintains  insurance
against  loss or  damage by fire or other  casualty  and such  other  insurance,
including but not limited to, product liability  insurance,  in such amounts and
covering  such risks as is  reasonably  adequate for the conduct of its business
and the value of its properties.

         (u) Tax Matters. The Company and each Subsidiary has filed all federal,
state and local income and  franchise  tax returns  required to be filed and has
paid all taxes shown by such returns to be due, and no tax  deficiency  has been
determined  adversely to the Company or any  Subsidiary  which has had (nor does
the Company or any Subsidiary have any knowledge of any tax deficiency which, if
determined  adversely to the Company or any  Subsidiary,  might have) a material
adverse effect on the business, properties,  operations, condition (financial or
other), results of operations, or prospects of the Company and the Subsidiaries,
taken as a whole.

         (v)  Investment  Company.  Neither the Company nor any Subsidiary is an
"investment  company"  within  the  meaning  of such term  under the  Investment
Company  Act of 1940,  as  amended,  and the  rules and  regulations  of the SEC
thereunder.

         (w) Absence of Brokers,  Finders,  Etc. No broker,  finder,  or similar
Person is entitled to any  commission,  fee, or other  compensation by reason of
the transactions  contemplated by this Agreement other than the Placement Agent,
and the Company shall pay, and  indemnify and hold harmless the Buyer from,  any
claim made  against  the Buyer by such  entity or any other  Person for any such
commission, fee or other compensation.

         (x) No  Solicitation.  No  form  of  general  solicitation  or  general
advertising was used by the Company or, to the best of its knowledge,  any other
Person  acting on behalf of the  Company,  in  respect of the  Securities  or in
connection with the offer and sale of the  Securities.  Neither the Company nor,
to its  knowledge,  any  Person  acting  on behalf of the  Company  has,  either
directly  or  indirectly,  sold or  offered  for sale to any  Person  any of the
Securities  (other than the Placement  Agent) or, within the six months prior to
the  date  hereof,   any  other  similar  security  of  the  Company  except  as
contemplated  by this  Agreement,  and the Company  represents  that neither the
Company  nor any Person  authorized  to act on its behalf will sell or offer for
sale any such security to, or solicit any offers to buy any such security  from,
or otherwise  approach or negotiate in respect  thereof  with,  any Person so as
thereby  to  cause  the  issuance  or  sale  of any of the  Securities  to be in
violation of any of the provisions of Section 5 of the 1933 Act.

         (y) Rights Agreement.  Assuming that the Buyer does not hold any shares
of Common  Stock  other than as  acquired  pursuant  to this  Agreement  or upon
conversion  of the 

                                      -20-
<PAGE>

Notes and the Warrant Notes or upon exercise of the Common Stock  Warrants,  and
subject to the  limitations  on the number of shares of Common Stock that may be
held  by the  Buyer  contained  therein,  the  execution  and  delivery  of this
Agreement by the Company,  the issuance of the Securities as contemplated by the
Transaction Documents and the other transactions contemplated by the Transaction
Documents  will not  result in the Buyer  becoming  an  "Acquiring  Person,"  as
defined in the Rights Agreement; and the holders of the Notes, the Warrant Notes
and the Common Stock Warrants will be entitled,  with respect to the Shares, and
the  holders  of the  Shares  will be  entitled,  in each  case to the  benefits
available to the holders of Common Stock under the Rights Agreement.

         (z) Certain Securities Law Matters. For purposes of Rule 144, the Buyer
will be  entitled  to tack the  holding  period of the  Outstanding  Note to the
holding  period of the  Exchange  Note issued to the Buyer in  exchange  for the
Outstanding  Note and, based on the law in effect on the date of this Agreement,
the Company will not take a contrary position on such matter.

         5. CERTAIN COVENANTS AND WAIVER.

         (a) Transfer  Restrictions.  The Buyer acknowledges and agrees that (1)
the Notes and the  Warrants to be issued and any Warrant  Notes and Common Stock
Warrants which may be issued to it hereunder are not being  registered under the
provisions of the 1933 Act or any state  securities laws and, except as provided
in Section 8, the Shares  have not been and are not being  registered  under the
1933 Act or any state  securities  laws, and that the Notes,  the Warrants,  the
Warrant Notes, and Common Stock Warrants may not be transferred unless the Buyer
shall  have  delivered  to  the  Company  an  opinion  of  counsel,   reasonably
satisfactory in form, scope and substance to the Company, to the effect that the
Note, the Warrant,  the Warrant Note, or the Common Stock Warrant or the portion
thereof to be transferred may be transferred without such registration or unless
transferred  in accordance  with Rule 144A to a QIB; (2) no sale,  assignment or
other  transfer of any Note,  Warrant,  Warrant Note, or Common Stock Warrant or
any interest  therein may be made except in accordance  with the terms  thereof;
(3) the Shares are not  transferable  in the absence of  registration  under the
1933  Act  and  applicable  state  securities  laws,  or  applicable  exemptions
therefrom;  (4) any sale of the  Securities  made in reliance on Rule 144 may be
made  only in  accordance  with the  terms  of said  Rule  and  further,  if the
exemption  provided by Rule 144 is not  available,  any resale of the Securities
under  circumstances in which the seller, or the Person through whom the sale is
made, may be deemed to be an underwriter,  as that term is used in the 1933 Act,
may require compliance with some other exemption under the 1933 Act or the rules
and  regulations  of the SEC  thereunder;  and  (5)  the  Company  is  under  no
obligation to register the Securities  (other than registration of the resale of
Registrable  Securities  in  accordance  with  Section 8) under the 1933 Act or,
except as  provided in Sections  5(d) and 8,  Section  3.12 of the Notes and the
Warrant  Notes,  Section 18 of the Warrants,  and Section 17 of the Common Stock
Warrants,  to comply with the terms and conditions of any exemption  thereunder.
Prior to the time  particular  Shares are eligible for resale under Rule 144(k),
the  Buyer  may not  transfer  such  Shares  in a  transaction  which  does  not
constitute a transfer thereof pursuant to the Registration Statement relating to
such Shares in accordance with the plan of distribution  set forth therein or in
any  supplement to the  Prospectus  unless the Buyer shall have delivered to the
Company  an opinion  of  counsel,  reasonably  satisfactory  in form,  scope and
substance  to  the  Company,   that  such  Shares  may  be  transferred  without
registration

                                      -21-
<PAGE>

under the 1933 Act. Nothing in any of the Transaction  Documents shall limit the
right of a holder of the  Securities  to make a bona fide  pledge  thereof to an
institutional lender.

         (b) Restrictive Legends. (1) The Buyer acknowledges and agrees that the
Notes and the Warrant Notes shall bear a restrictive legend in substantially the
following form (and a stop-transfer  order may be placed against transfer of the
Notes and the Warrant Notes):

     This Note has not been  registered  under the  Securities  Act of 1933,  as
     amended (the "1933 Act"), or any state securities laws. The issuance to the
     holder of this Note of the shares of Common Stock issuable upon  conversion
     of this Note,  in payment of  interest  on this Note and upon  exercise  of
     Common Stock Warrants issuable upon redemption of this Note are not covered
     by a registration  statement under the 1933 Act or registration under state
     securities  laws.  This Note has been acquired for investment  only and may
     not be sold,  transferred  or  assigned  unless  (1) the  resale  hereof is
     registered  under the 1933 Act,  (2) the Company has received an opinion of
     counsel reasonably satisfactory in form, scope and substance to the Company
     that such registration is not required or (3) sold, transferred or assigned
     to a QIB pursuant to Rule 144A.

         (2) The Buyer further  acknowledges  and agrees that each Warrant shall
bear  a  restrictive   legend  in  substantially   the  following  form  (and  a
stop-transfer order may be placed against each Warrant);

     This Warrant has not been  registered  under the Securities Act of 1933, as
     amended (the "1933 Act"), or applicable  state  securities laws and may not
     be sold, transferred or assigned unless (1) the resale hereof is registered
     under the 1933 Act,  (2) the  Company  has  received  an opinion of counsel
     reasonably  satisfactory  in form,  scope and substance to the Company that
     such registration is not required or (3) sold, transferred or assigned to a
     QIB pursuant to Rule 144A.

     This  Warrant is issued  pursuant to a  Securities  Purchase  and  Exchange
     Agreement,  dated as of March 19, 1999,  by and between the Company and the
     original  holder of this  Warrant,  as amended  from time to time,  and the
     holder of this Warrant and this Warrant are subject to certain of the terms
     of the Securities Purchase and Exchange Agreement.

         (3) The Buyer further  acknowledges  and agrees that until such time as
the Shares have been registered for resale under the 1933 Act as contemplated by
Section 8 or are  eligible  for resale under Rule 144(k) under the 1933 Act, the
certificates for the Shares,  may bear a restrictive legend in substantially the
following form (and a stop-transfer  order may be placed against transfer of the
certificates for the Shares):

     The securities  represented by this  certificate  have not been  registered
     under the  Securities  Act of 1933, as amended.  The  securities  have been
     acquired for investment  and may not be resold,  transferred or assigned in
     the absence of an effective registration statement for the securities under
     the Securities Act of 1933, as amended, or an opinion of counsel reasonably
     satisfactory in form, scope and substance to the Company that  registration
     is not required under said Act.

                                      -22-
<PAGE>

         (4) Once the  Registration  Statement has been declared  effective,  or
particular Shares are eligible for resale pursuant to Rule 144(k) under the 1933
Act,  thereafter  (A) upon  request  of the Buyer the  Company  will  substitute
certificates  without  restrictive  legend for  certificates for any such Shares
issued prior to the SEC Effective Date or the time of such  eligibility,  as the
case may be,  which bear such  restrictive  legend and remove any  stop-transfer
restriction  relating  thereto  promptly,  but in no event later than three days
after surrender of such  certificates by the Buyer and (B) the Company shall not
place any restrictive legend on certificates for such Shares subsequently issued
or impose any stop-transfer restriction thereon.

         (c) Nasdaq Listing;  Reporting Status.  Not later than the Business Day
following the Closing Date,  the Company will file with Nasdaq an application or
other document  required by Nasdaq for the listing of the Shares with Nasdaq and
shall  provide  evidence  of such  filing  to the  Buyer.  So long as the  Buyer
beneficially owns any portion of any of the Securities, the Company will use its
best  efforts to maintain  the listing of the Common  Stock on Nasdaq or another
national securities exchange.  During the Registration Period, the Company shall
timely file all reports required to be filed with the SEC pursuant to Section 13
or 15(d) of the 1934 Act, and the Company  shall not  terminate its status as an
issuer  required to file reports  under the 1934 Act even if the 1934 Act or the
rules and regulations  thereunder would permit such termination.  So long as the
Buyer beneficially owns any of the Securities,  the Company shall furnish to the
Buyer copies of all reports and other  information filed by the Company with the
SEC pursuant to Sections 13,  14(a),  14(c) and 15(d) of the 1934 Act  promptly,
but in no event later than ten days, after the same are filed with the SEC.

         (d) Form D. The Company agrees to file one or more Forms D with respect
to the Securities as required under Regulation D to claim the exemption provided
by Rule 506 of Regulation D and to provide a copy thereof to the Buyer  promptly
after such filing.

         (e) State  Securities  Laws. On or before the Closing Date, the Company
shall  take  such  action  as shall be  necessary  to  qualify,  or to obtain an
exemption for, the offer and sale of the Securities to the Buyer as contemplated
by the Transaction  Documents under such of the securities laws of jurisdictions
in the United States as shall be  applicable  thereto.  In  connection  with the
foregoing obligations of the Company in this Section 5(e), the Company shall not
be required (1) to qualify to do business in any jurisdiction where it would not
otherwise  be  required  to qualify but for this  Section  5(e),  (2) to subject
itself  to  general  taxation  in any such  jurisdiction,  (3) to file a general
consent  to service of  process  in any such  jurisdiction,  (4) to provide  any
undertakings  that cause more than  nominal  expense or burden to the Company or
(5) to make any change in its charter or by-laws which the Board of Directors of
the Company  determines to be contrary to the best  interests of the Company and
its  stockholders.  The  Company  shall  furnish  the Buyer  with  copies of all
filings, applications, orders and grants or confirmations of exemptions relating
to such securities laws on or before the Closing Date.

         (f)  Limitation  on Certain  Actions.  From the date of  execution  and
delivery of this  Agreement by the parties hereto to the date of issuance of the
Notes,  the  Company (1) shall  comply  with  Article III of the Notes as if the
Notes were  outstanding,  (2) shall not take any action which, if the Notes were
outstanding,  (A) would  constitute  an Event of Default  or, with the giving of
notice or the passage of time, or both,  would constitute an Event of Default or
(B)

                                      -23-
<PAGE>

would constitute a Repurchase Event or, with the giving of notice or the passage
of time, or both, would constitute a Repurchase Event.

         (g) Use of Proceeds.  The Company  represents  and agrees that:  (1) it
does not own or have any present  intention of acquiring any Margin  Stock;  (2)
the proceeds of sale of the Notes, the Warrant Notes and the Warrant Shares will
be used  for  general  working  capital  purposes  and in the  operation  of the
Company's  business;  (3)  none  of such  proceeds  will be  used,  directly  or
indirectly  (A) to make any loan to or investment in any other Person or (B) for
the purpose,  whether  immediate,  incidental  or  ultimate,  of  purchasing  or
carrying  any  Margin  Stock or for the  purpose  of  maintaining,  reducing  or
retiring any indebtedness which was originally incurred to purchase or carry any
stock that is  currently  a Margin  Stock or for any other  purpose  which might
constitute the  transactions  contemplated by this Agreement a "purpose  credit"
within the  meaning of  Regulation  U of the Board of  Governors  of the Federal
Reserve  System;  and (4) neither the Company nor any agent acting on its behalf
has taken or will take any  action  which  might  cause  this  Agreement  or the
transactions  contemplated  hereby to violate  Regulation T, Regulation U or any
other  regulation of the Board of Governors of the Federal  Reserve System or to
violate the 1934 Act, in each case as in effect now or as the same may hereafter
be in effect.

         (h) Best Efforts. Each of the parties shall use its best efforts timely
to satisfy each of the  conditions to the other party's  obligations to sell and
purchase  the Notes and issue and acquire the Warrants set forth in Section 6 or
7, as the case may be, of this  Agreement on or before the Closing  Date. If the
Buyer or the Company shall  exercise any of its rights under the Warrants,  each
of the  parties  shall  use its  best  efforts  timely  to  satisfy  each of the
applicable  conditions to the other party's obligations  thereunder on or before
the applicable date for closing the particular transaction.

         (i) Debt Obligation. So long as any portion of any Note or Warrant Note
is  outstanding,  the  Company  shall  cause its books,  records  and  financial
statements  to reflect the Notes and the Warrant Note as debts of the Company in
the unpaid principal amount thereof and, whenever  appropriate,  as valid senior
debt obligations of the Company for money borrowed.

         (j) Buyer's  Waiver.  The Buyer, on behalf of itself and any subsequent
holder of the Outstanding  Note,  hereby waives any requirements or restrictions
contained  in  the  Outstanding  Note  which  would  restrict  or  prohibit  the
transactions  contemplated by this Agreement and the Other  Securities  Purchase
Agreements  and any "Event of Default"  under and as defined in the  Outstanding
Note  (and the  consequences  thereof)  which  would  otherwise  arise  from the
execution  and  delivery of this  Agreement  and the Other  Securities  Purchase
Agreements and completion of the transactions contemplated hereby and thereby.

         6. CONDITIONS TO THE COMPANY'S OBLIGATION TO SELL AND EXCHANGE.

         The Buyer  understands  that the Company's  obligations  to sell to the
Buyer the  Purchase  Note and to issue to the Buyer the  Warrant to be issued to
the Buyer pursuant to Section 2(a) on the Closing Date and to issue to the Buyer
the Exchange Note, if any, and to issue to the Buyer the Warrant to be issued to
the Buyer pursuant to Section 2(c) in exchange for the Outstanding Note, if any,
on the  Exchange  Date  are  conditioned  upon  satisfaction  of  the

                                      -24-
<PAGE>

following  conditions  precedent  on or before the  Closing  Date (any or all of
which may be waived by the Company in its sole discretion):

         (a) On the Closing Date, no legal action,  suit or proceeding  shall be
pending or  threatened  which seeks to restrain  or  prohibit  the  transactions
contemplated by this Agreement;

         (b) The  representations  and warranties of the Buyer contained in this
Agreement and in the Questionnaire  shall have been true and correct on the date
of this  Agreement and on the Closing Date as if made on the Closing Date and on
or before the Closing  Date the Buyer shall have  performed  all  covenants  and
agreements  of the Buyer  required to be performed by the Buyer on or before the
Closing Date; and

         (c) No event which, if the Notes were  outstanding (1) would constitute
an Event of Default  under and as  defined  in the Notes or,  with the giving of
notice or the passage of time,  or both,  would  constitute  an Event of Default
under and as defined in the Notes shall have  occurred and be  continuing or (2)
would  constitute a Repurchase  Event under and as defined in the Notes or, with
the  giving  of notice or the  passage  of time,  or both,  would  constitute  a
Repurchase  Event under and as defined in the Notes shall have  occurred  and be
continuing  unless the Buyer shall have  waived in writing  such (and only such)
Event of Default or Repurchase  Event, as the case may be, and the rights of the
Buyer  under the Notes with  respect to such (and only such) Event of Default or
Repurchase Event, as the case may be.

         7. CONDITIONS TO THE BUYER'S OBLIGATIONS TO PURCHASE AND EXCHANGE.

(a)  Closing  Date.  The Company  understands  that the  Buyer's  obligation  to
purchase  from the Company the Purchase Note and to acquire from the Company the
Warrant to be acquired from the Company  pursuant to Section 2(a) on the Closing
Date and to exchange the  Outstanding  Note,  if any, for the Exchange  Note, if
any, on the Exchange Date are  conditioned  upon  satisfaction  of the following
conditions  precedent  on or before the Closing Date (any or all of which may be
waived by the Buyer in its sole discretion):

         (1) On the Closing Date, no legal action,  suit or proceeding  shall be
pending or  threatened  which seeks to restrain  or  prohibit  the  transactions
contemplated by this Agreement;

         (2) The representations and warranties of the Company contained in this
Agreement  shall have been true and  correct on the date of this  Agreement  and
shall  be true  and  correct  on the  Closing  Date as if given on and as of the
Closing  Date (except for  representations  given as of a specific  date,  which
representations  shall be true and  correct  as of such date and  except for the
approvals  referred  to in clause (3) of  Section  4(h),  which  shall have been
obtained on or before the Closing  Date),  and on or before the Closing Date the
Company  shall have  performed  all  covenants  and  agreements  of the  Company
contained  herein  required  to be  performed  by the  Company  on or before the
Closing Date;

         (3) No event which, if the Notes were  outstanding (1) would constitute
an Event of Default  under and as  defined  in the Notes or,  with the giving of
notice or the passage of time,  or both,  would  constitute  an Event of Default
under and as defined in the Notes shall

                                      -25-
<PAGE>

have occurred and be continuing or (2) would  constitute a Repurchase  Event or,
with the giving of notice or the passage of time,  or both,  would  constitute a
Repurchase  Event under and as defined in the Notes shall have  occurred  and be
continuing;

         (4) The Company shall have delivered to the Buyer a certificate,  dated
the  Closing  Date,  duly  executed  by its  Chief  Executive  Officer  or Chief
Financial Officer to the effect set forth in subparagraphs  (1), (2), and (3) of
this Section 7(a);

         (5) The Company shall have delivered to the Buyer a certificate,  dated
the Closing Date, of the Secretary of the Company certifying (A) the Certificate
of  Incorporation  and By-Laws of the Company as in effect on the Closing  Date,
(B) all  resolutions of the Board of Directors (and  committees  thereof) of the
Company relating to the Transaction Documents and the transactions  contemplated
hereby and (C) such other matters as reasonably requested by the Buyer;

         (6) The Transfer Agent shall have  acknowledged  receipt of the Issuing
Agent Instruction;

         (7) On the Closing  Date,  the Buyer shall have  received an opinion of
Cooley Godward LLP, counsel for the Company,  dated the Closing Date,  addressed
to the Buyer, in form, scope and substance reasonably satisfactory to the Buyer,
substantially in the form of Annex IV to this Agreement;

         (8) On the Closing  Date,  the Buyer shall have  received an opinion of
Lyon & Lyon LLP,  special  counsel  for the  Company,  dated the  Closing  Date,
addressed to the Buyer, in form, scope and substance reasonably  satisfactory to
the Buyer, substantially in the form of Annex V to this Agreement; and

         (9) On the Closing Date (i) trading in securities on the New York Stock
Exchange,  Inc., the American Stock Exchange, Inc. or Nasdaq shall not have been
suspended or  materially  limited and (ii) a general  moratorium  on  commercial
banking activities in the State of California or the State of New York shall not
have been declared by either federal or state authorities.

         (b) Exchange  Date.  The Company  understands  that, in addition to the
conditions  precedent in Section  7(a),  the Buyer's  obligation to exchange the
Outstanding Note, if any, for the Exchange Note, if any, on the Exchange Date is
conditioned  upon  satisfaction  of the  following  conditions  precedent on the
Exchange  Date  (any or all of  which  may be  waived  by the  Buyer in its sole
discretion):

         (1) On the Exchange Date, no legal action,  suit or proceeding shall be
pending or  threatened  which seeks to restrain  or  prohibit  the  transactions
contemplated by this Agreement;

         (2) The representations and warranties of the Company contained in this
Agreement  insofar as they relate to the Exchange Note and the Warrants issuable
pursuant  to Section  2(c) shall have been true and  correct on the date of this
Agreement  and shall be true and correct on the Exchange Date as if given on and
as of the Exchange Date (except for representations given as of a specific date,
which  representations  shall be true and correct as

                                      -26-
<PAGE>

of such date and except for the approvals referred to in clauses (1) through (4)
of Section 4(h), which shall have been obtained on or before the Exchange Date),
and on or  before  the  Exchange  Date the  Company  shall  have  performed  all
covenants  and  agreements  of  the  Company  contained  herein  required  to be
performed by the Company on or before the Exchange Date;

         (3) No Event of Default  under and as defined in the Notes and no event
which,  with the  giving  of  notice  or the  passage  of time,  or both,  would
constitute  an Event of Default  under and as  defined  in the Notes  shall have
occurred and be continuing and (2) no Repurchase Event and no event which,  with
the  giving  of notice or the  passage  of time,  or both,  would  constitute  a
Repurchase  Event under and as defined in the Notes shall have  occurred  and be
continuing;

         (4) The Company shall have delivered to the Buyer a certificate,  dated
the  Exchange  Date,  duly  executed  by its Chief  Executive  Officer  or Chief
Financial Officer to the effect set forth in subparagraphs  (1), (2), and (3) of
this Section 7(b);

         (5) The SEC  Effective  Date shall have  occurred and the  Registration
Statement  shall be effective  and  available  for use under the 1933 Act by the
Buyer for resale of the Registrable  Securities required to be included therein;
and

         (6) On the  Exchange  Date (i)  trading in  securities  on the New York
Stock Exchange, Inc., the American Stock Exchange, Inc. or Nasdaq shall not have
been suspended or materially limited and (ii) a general moratorium on commercial
banking activities in the State of California or the State of New York shall not
have been declared by either federal or state authorities.

         8. REGISTRATION RIGHTS.

         (a)  Mandatory  Registration.  (1) The Company shall prepare and, on or
prior to the date which is 30 days after the Closing  Date,  file with the SEC a
Registration Statement on Form S-3 which covers the resale by the Buyer of (A) a
number  of shares of Common  Stock  equal to at least the  number of  Conversion
Shares  issuable to the Buyer  under the  Purchase  Note and the Warrant  Notes,
determined  as if the Purchase Note and the Warrant  Notes,  together with three
months'  accrued and unpaid  interest  thereon,  were  converted  in full at the
Conversion  Price in  effect on the SEC  Filing  Date,  and (B) such  additional
number  of  shares  of  Common  Stock as the  Company  shall  in its  discretion
determine to register in connection with the issuance of the Interest Shares and
Warrant Shares,  as Registrable  Securities,  and which  Registration  Statement
shall  state  that,  in  accordance  with  Rule  416  under  the 1933  Act,  the
Registration  Statement  also covers  such  indeterminate  number of  additional
shares of Common Stock as may become  issuable upon  conversion of the Notes and
the Warrant Notes or exercise of the Common Stock  Warrants to prevent  dilution
resulting from stock splits, stock dividends or similar transactions.

         (2) Prior to the SEC Effective  Date the Company will not,  without the
prior written consent of the Majority  Holders,  request the acceleration of any
other registration  statement filed with the SEC, and during any time subsequent
to the SEC Effective Date when the Registration  Statement for any reason is not
available for use by any Investor for the resale of any Registrable  Securities,
the Company  shall not file any other  registration  statement or any

                                      -27-
<PAGE>

amendment thereto with the SEC under the 1933 Act or request the acceleration of
the effectiveness of any other registration  statement previously filed with the
SEC,  other  than  (A)  any  registration  statement  on  Form  S-8  and (B) any
registration  statement or amendment which the Company is required to file or as
to which the  Company  is  required  to  request  acceleration  pursuant  to any
obligation in effect on the date of execution and delivery of this Agreement.

         (3) The Company shall use its best efforts to maintain its  eligibility
to use Form S-3 for  registration  of the resale of shares of its  Common  Stock
under  the  1933  Act so long  as Form  S-3 is  generally  available  for use by
registrants for  registration of the resale of common stock,  and if Form S-3 is
rescinded by the SEC or, despite such efforts,  the Company is ineligible to use
Form S-3 then the Company  will use  commercially  reasonable  efforts to become
eligible and maintain its  eligibility to use "short form" for  registration  of
the resale of shares of its Common  Stock;  provided,  however,  that nothing in
this  Section  8(a)(3)  shall  require the Company to issue shares of its Common
Stock in order to meet any public "float" requirement for eligibility to use any
such  registration  form or to meet  any  asset,  net  worth or  tangible  asset
requirement for eligibility to use any such registration form.

         (b) Obligations of the Company.  In connection with the registration of
the Registrable Securities, the Company shall:

         (1) use its best efforts to cause the Registration  Statement to become
effective as promptly as possible after the Closing and to keep the Registration
Statement  effective  pursuant to Rule 415 at all times during the  Registration
Period.  The Company shall submit to the SEC,  within three  Business Days after
the Company learns that no review of the Registration  Statement will be made by
the staff of the SEC or that the staff of the SEC has no further comments on the
Registration  Statement,  as the case  may be, a  request  for  acceleration  of
effectiveness of the Registration Statement to a time and date not later than 48
hours after the submission of such request.  The Company represents and warrants
to the Investors that (a) the Registration  Statement  (including any amendments
or supplements thereto and prospectuses  contained  therein),  at the time it is
first filed with the SEC, at the time it is ordered  effective by the SEC and at
all times during which it is required to be effective  hereunder  (and each such
amendment  and  supplement at the time it is filed with the SEC and at all times
during which it is available  for use in  connection  with the offer and sale of
the Registrable Securities) shall not contain any untrue statement of a material
fact or omit to state a material fact required to be stated therein or necessary
to make the statements  therein not misleading  and (b) the  Prospectus,  at the
time the  Registration  Statement  is declared  effective  by the SEC and at all
times that the  Prospectus is required by this Agreement to be available for use
by any  Investor  and, in  accordance  with  Section  8(c)(4),  any  Investor is
entitled to sell Registrable  Securities  pursuant to the Prospectus,  shall not
contain any untrue statement of a material fact or omit to state a material fact
required to be stated therein,  or necessary to make the statements  therein, in
light of the circumstances in which they were made, not misleading;

         (2)  subject to  Section  8(b)(5),  prepare  and file with the SEC such
amendments  (including   post-effective   amendments)  and  supplements  to  the
Registration  Statement  and the  Prospectus  as may be  necessary  to keep  the
Registration  Statement  effective,  and the  Prospectus  current,  at all times
during the Registration Period, and, during the Registration Period, comply with
the  provisions of the 1933 Act applicable to the Company in order to permit the
disposition  by the  Investors  of all  Registrable  Securities  covered  by the
Registration Statement;

                                      -28-
<PAGE>

         (3) furnish to each Investor whose Registrable  Securities are included
in the Registration  Statement and its legal counsel (1) promptly after the same
is  prepared  and  publicly  distributed,  filed with the SEC or received by the
Company,  one copy of the Registration  Statement and any amendment  thereto and
the Prospectus and each  amendment or supplement  thereto,  (2) one copy of each
letter written by or on behalf of the Company to the SEC or the staff of the SEC
and each item of correspondence from the SEC or the staff of the SEC relating to
the Registration Statement (other than any portion of any thereof which contains
information for which the Company has sought  confidential  treatment),  each of
which the Company hereby determines to be confidential information and which the
Buyer hereby agrees to keep confidential as a confidential  Record in accordance
with  Section  8(b)(9) and (3) such number of copies of the  Prospectus  and all
amendments and supplements  thereto and such other  documents,  as such Investor
may reasonably request in order to facilitate the disposition of the Registrable
Securities owned by such Investor;

         (4) subject to Section  8(b)(5),  use its best  efforts (i) to register
and qualify the Registrable  Securities  covered by the  Registration  Statement
under the securities or blue sky laws of such jurisdictions as the Investors who
hold a majority in interest of the Registrable  Securities  reasonably  request,
(ii) to prepare and to file in those  jurisdictions  such amendments  (including
post-effective   amendments)   and   supplements  to  such   registrations   and
qualifications as may be necessary to maintain the effectiveness  thereof at all
times  during  the  Registration  Period  and  (iii) to take all  other  actions
reasonably necessary or advisable to qualify the Registrable Securities for sale
by the  Investors in such  jurisdictions;  provided,  however,  that the Company
shall not be required in connection  therewith or as a condition  thereto (I) to
qualify to do  business  in any  jurisdiction  where it would not  otherwise  be
required  to qualify but for this  Section  8(b)(4),  (II) to subject  itself to
general  taxation in any such  jurisdiction,  (III) to file a general consent to
service of process in any such  jurisdiction,  (IV) to provide any  undertakings
that cause more than nominal expense or burden to the Company or (V) to make any
change in its  charter or by-laws  which the Board of  Directors  of the Company
determines  to be  contrary  to the  best  interests  of  the  Company  and  its
stockholders;

         (5) (A) as promptly as  practicable  after becoming aware of such event
or  circumstance,  notify  each  Investor  of  the  occurrence  of an  event  or
circumstance  of which the  Company has  knowledge  (x) as a result of which the
Prospectus,  as then in effect,  includes an untrue statement of a material fact
or omits to state a material fact required to be stated  therein or necessary to
make the statements therein, in light of the circumstances under which they were
made,  not  misleading or (y) which  requires the Company to amend or supplement
the  Registration  Statement  due to the  receipt  from  an  Investor  of new or
additional  information about such Investor or its intended plan of distribution
of its Registrable  Securities,  and use its best efforts  promptly to prepare a
supplement or amendment to the Registration  Statement and Prospectus to correct
such untrue  statement or omission or to add any new or additional  information,
and deliver a number of copies of such  supplement or amendment to each Investor
as such Investor may reasonably request;

         (B)  notwithstanding  Section  8(b)(5)(A)  above,  if at any  time  the
Company  notifies the Investors as contemplated  by Section  8(b)(5)(A) that the
event giving rise to such notice relates to a development  involving the Company
which occurred subsequent to the later of (x) the SEC Effective Date and (y) the
latest  date  prior  to  such  notice  on  which  the  Company  has  amended  or
supplemented the Registration Statement,  then the Company shall not be required
to use best efforts to make such amendment during a Blackout  Period;  provided,

                                      -29-
<PAGE>

however,  that the aggregate number of Trading Days on which any Blackout Period
is in effect may not exceed 20 Trading Days (whether or not  consecutive) in any
period of 12 consecutive months; and provided further, however, that no Blackout
Period may commence within 40 Trading Days after the end of an earlier  Blackout
Period;

         (6) as  promptly as  practicable  after  becoming  aware of such event,
notify each  Investor who holds  Registrable  Securities  being  offered or sold
pursuant to the  Registration  Statement  of the issuance by the SEC of any stop
order or other suspension of effectiveness of the Registration  Statement at the
earliest possible time;

         (7) permit the Investors who hold Registrable Securities being included
in the Registration  Statement, at such Investors' sole cost and expense (except
as  otherwise  specifically  provided  in  Section  10(k)) to review  and have a
reasonable  opportunity  to  comment  on  the  Registration  Statement  and  all
amendments  and  supplements  thereto at least five Business Days prior to their
filing with the SEC and shall not file any such  document to which any  Investor
reasonably objects; provided, however, that all comments by such Investors shall
be  given  to the Law  Offices  of  Brian W Pusch  (or  such  other  counsel  as
designated  by  Investors  who hold a majority in  interest  of the  Registrable
Securities  proposed to be offered by the  Registration  Statement) to convey to
the Company;

         (8)  make  generally  available  to its  security  holders  as  soon as
practical,  but not later  than 90 days  after the close of the  period  covered
thereby, an earning statement (in form complying with the provisions of Rule 158
under the 1933 Act)  covering a  12-month  period  beginning  not later than the
first day of the Company's  fiscal quarter next following the SEC Effective Date
of the Registration Statement;

         (9) make  available  for  inspection  by any Investor and any Inspector
retained by such Investor at such Investor's sole expense,  all Records as shall
be  reasonably  necessary to enable such  Investor to exercise its due diligence
responsibility  with  respect to Section 11 of the 1933 Act as it relates to the
Registration  Statement  or any  amendment  thereof,  and  cause  the  Company's
officers to supply all  information  which any Inspector may reasonably  request
for purposes of such due diligence;  provided, however, that such Investor shall
hold in  confidence  and shall not make any  disclosure  of any  Record or other
information which the Company  determines in good faith to be confidential,  and
of which determination such Investor is so notified, unless (i)the disclosure of
such Record is necessary to avoid or correct a  misstatement  or omission in the
Registration Statement, (ii) the release of such Record is ordered pursuant to a
subpoena  or  other  order  from a  court  or  governmental  body  of  competent
jurisdiction  or (iii) the  information  in such Record has been made  generally
available  to the public  other than by  disclosure  in violation of this or any
other agreement;  provided further, however, that each Investor understands that
in the course of  exercising  the rights  provided in this Section  8(b)(9) such
Investor may come into possession of material  non-public  information about the
Company and that by reason of the requirements of the 1934 Act any such Investor
who possesses such material  non-public  information may be restricted in making
purchases  and  sales of the  Common  Stock  unless  such  information  has been
publicly  disclosed.   The  Company  shall  not  be  required  to  disclose  any
confidential  information in such Records to any Inspector until and unless such
Inspector shall have entered into a  confidentiality  agreement with the Company
with respect thereto,  substantially in the form of this Section 8(b)(9),  which
agreement  shall permit such  Inspector to disclose  Records to the Investor who
has retained such Inspector.  Each Investor agrees that it shall,  upon learning
that disclosure of such

                                      -30-
<PAGE>

Records  is  sought  in  or  by  a  court  or  governmental  body  of  competent
jurisdiction or through other means, give prompt notice to the Company and allow
the  Company,  at the  Company's  expense,  to undertake  appropriate  action to
prevent  disclosure of, or to obtain a protective  order for, the Records deemed
confidential.  The  Company  shall  hold in  confidence  and  shall not make any
disclosure  of  information  concerning  an  Investor  provided  to the  Company
pursuant  to  this  Agreement  unless  (i)  disclosure  of such  information  is
necessary to comply with federal or state  securities  laws,  (ii) disclosure of
such  information is necessary to avoid or correct a misstatement or omission in
the  Registration  Statement,  (iii)  release  of such  information  is  ordered
pursuant  to a  subpoena  or other  order from a court or  governmental  body of
competent  jurisdiction,  or (iv)  such  information  has  been  made  generally
available  to the public  other than by  disclosure  in violation of this or any
other agreement. The Company agrees that it shall, upon learning that disclosure
of such  information  concerning  an  Investor  is  sought  in or by a court  or
governmental body of competent  jurisdiction or through other means, give prompt
notice to such Investor and allow such Investor,  at such Investor's expense, to
undertake appropriate action to prevent disclosure of, or to obtain a protective
order for, such information;

         (10)  use its best  efforts  to cause  all the  Registrable  Securities
covered by the Registration  Statement as of the SEC Effective Date to be listed
on Nasdaq or such other principal  securities  market on which securities of the
same class or series issued by the Company are then listed or traded;

         (11)  provide a  transfer  agent and  registrar,  which may be a single
entity, for the Registrable Securities at all times;

         (12) cooperate with the Investors who hold Registrable Securities being
offered  pursuant  to  the  Registration  Statement  to  facilitate  the  timely
preparation and delivery of certificates  (not bearing any restrictive  legends)
representing  Registrable  Securities to be offered pursuant to the Registration
Statement and enable such certificates to be in such denominations or amounts as
the  Investors  may  reasonably  request  and  registered  in such  names as the
Investors may request;  and, not later than the SEC Effective  Date, the Company
shall  deliver (i) to the  Transfer  Agent (with copies to the  Investors  whose
Registrable   Securities  are  included  in  the   Registration   Statement)  an
instruction  substantially  in the form of Annex VI to this  Agreement  and (ii)
shall cause legal  counsel  selected by the Company to deliver to the  Investors
whose Registrable  Securities are included in the Registration Statement and, if
required by the Transfer  Agent,  to the Transfer Agent opinions of counsel,  in
the forms of Annex VII and Annex VIII to this Agreement; and

         (13) during the Registration  Period,  the Company shall not bid for or
purchase  any Common  Stock or any right to purchase  Common Stock or attempt to
induce any Person to purchase any such  security or right if such bid,  purchase
or attempt would in any way limit the right of the Investors to sell Registrable
Securities by reason of the limitations set forth in Regulation M under the 1934
Act.

         (c)  Obligations of the Buyer and other  Investors.  In connection with
the  registration  of the Registrable  Securities,  the Investors shall have the
following obligations:

         (1) It shall be a condition precedent to the obligations of the Company
to complete  the  registration  pursuant to this  Agreement  with respect to the
Registrable Securities

                                      -31-
<PAGE>

of a particular  Investor  that such  Investor  shall furnish to the Company the
Required  Information  and shall execute such documents in connection  with such
registration as the Company may reasonably  request. At least four Business Days
prior to the first anticipated  filing date of the Registration  Statement,  the
Company  shall notify each Investor of the Required  Information  if any of such
Investor's Registrable Securities are eligible for inclusion in the Registration
Statement. If at least one Business Day prior to the SEC Filing Date the Company
has not received the Required Information from an Investor, then the Company may
file the Registration Statement without including Registrable Securities of such
Non-Responsive  Investor;  provided,  however, that nothing herein shall relieve
the  Company  of its  obligation  to  register  the  resale  of such  Investor's
Registrable  Securities  promptly  after such  Investor  provides  the  Required
Information to the Company.

         (2) Each  Investor by such  Investor's  acceptance  of the  Registrable
Securities  agrees to cooperate with the Company as reasonably  requested by the
Company  in  connection  with the  preparation  and  filing of the  Registration
Statement  hereunder,  unless such  Investor  has  notified  the Company of such
Investor's  election to exclude all of such  Investor's  Registrable  Securities
from the Registration Statement;

         (3) Each Investor agrees that it will not effect any disposition of the
Registrable  Securities except as contemplated in the Registration  Statement or
as otherwise in  compliance  with  applicable  securities  laws and that it will
promptly notify the Company of any material changes in the information set forth
in  the  Registration   Statement   regarding  such  Investor  or  its  plan  of
distribution;  each Investor  agrees (a) to notify the Company in the event that
such Investor  enters into any material  agreement with a broker or a dealer for
the sale of the Registrable  Securities through a block trade, special offering,
exchange  distribution or a purchase by a broker or dealer and (b) in connection
with such  agreement,  to provide to the  Company  in  writing  the  information
necessary to prepare any supplemental  prospectus  pursuant to Rule 424(c) under
the 1933 Act which is required with respect to such transaction;

         (4) Each  Investor  acknowledges  that  during the times  specified  in
Section  8(b)(5) or 8(b)(6) the Company must  suspend the use of the  Prospectus
until such time as an amendment to the Registration  Statement has been filed by
the Company  and  declared  effective  by the SEC,  the  Company has  prepared a
supplement to the Prospectus or the Company has filed an appropriate report with
the SEC pursuant to the 1934 Act. Each Investor  hereby  covenants  that it will
not sell any  Registrable  Securities  pursuant to the  Prospectus in accordance
with  Section  8(b)(5) or 8(b)(6)  during the period  commencing  at the time at
which the Company gives such Investor notice of the suspension of the use of the
Prospectus  and ending at the time the Company gives such  Investor  notice that
such Investor may thereafter  effect sales pursuant to the Prospectus,  or until
the Company delivers to such Investor an amended or supplemented Prospectus;

         (5) In connection with any sale of Registrable Securities which is made
by an Investor  pursuant to the Registration  Statement (A) if such sale is made
through a broker,  such Investor shall instruct its broker or brokers to deliver
the  Prospectus to the  purchaser or  purchasers  in connection  with such sale,
shall  supply  copies of the  Prospectus  to such  broker or  brokers  and shall
instruct  such broker or brokers to deliver such  Prospectus to the purchaser in
such sale or such purchaser's  broker, (B) if such sale is made in a transaction
directly  with a  purchaser  and not through the  facilities  of any  securities
exchange or market, such Investor shall deliver,  or cause to be delivered,  the
Prospectus  to such  purchaser;  and (C) if such sale is

                                      -32-
<PAGE>

made by any means  other  than  those  described  in the  immediately  preceding
clauses (A) and (B),  such Investor  shall  otherwise  use its  reasonable  best
efforts to comply  with the  prospectus  delivery  requirements  of the 1933 Act
applicable to such sale; and

         (6) Each Investor agrees to notify the Company promptly after the event
of the completion of the sale by such Investor of all Registrable  Securities to
be sold by such Investor pursuant to the Registration Statement.

         (d) Rule 144.  With a view to making  available  to each  Investor  the
benefits of Rule 144, the Company agrees:

         (1) to promptly  furnish to each Investor so long as such Investor owns
Registrable  Securities,  such  information  as may be  necessary to permit each
Investor  to  sell   Registrable   Securities   pursuant  to  Rule  144  without
registration; and

         (2) if at any time the  Company is not  required  to file such  reports
with the SEC under Sections 13 or 15(d) of the 1934 Act, to use its best efforts
to, upon the request of an Investor,  make publicly  available other information
so long as is  necessary  to  permit  publication  by  brokers  and  dealers  of
quotations  for the  Common  Stock and sales of the  Registrable  Securities  in
accordance with Rule 15c2-11 under the 1934 Act.

         9. INDEMNIFICATION AND CONTRIBUTION.

         (a)  Indemnification.  (1) To the extent not  prohibited  by applicable
law,  the Company will  indemnify  and hold  harmless  each  Indemnified  Person
against any Claims to which any of them may become  subject  under the 1933 Act,
the 1934 Act or  otherwise,  insofar as such Claims (or actions or  proceedings,
whether  commenced or threatened,  in respect thereof) arise out of or are based
upon any Violation or any of the  transactions  contemplated  by the Transaction
Documents. Subject to the restrictions set forth in Section 9(a)(3) with respect
to the number of legal  counsel,  the Company shall  reimburse the Investors and
each such controlling Person, promptly as such expenses are incurred and are due
and payable,  for any documented  reasonable  legal fees or other documented and
reasonable  expenses  incurred  by  them in  connection  with  investigating  or
defending  any such Claim.  Notwithstanding  anything to the contrary  contained
herein, the  indemnification  agreement  contained in this Section 9(a)(1) shall
not apply to: (I) a Claim arising out of or based upon a Violation  which occurs
in reliance upon and in conformity with  information  relating to an Indemnified
Person  furnished  in  writing  to the  Company  by such  Indemnified  Person or
underwriter for such Indemnified Person expressly for use in connection with the
preparation  of the  Registration  Statement  or any such  amendment  thereof or
supplement  thereto,  if the Prospectus was timely made available by the Company
pursuant to Section 8(b)(3) hereof; (II) amounts paid in settlement of any Claim
if such settlement is effected without the prior written consent of the Company,
which consent shall not be unreasonably  withheld;  (III) an Indemnified  Person
with respect to a Claim which arises solely from the failure of such Indemnified
Person to comply in any material  respect with Section  8(c)(4) or 8(c)(5);  and
(IV) any Investor  with respect to a Claim by the Company  against such Investor
to the extent and solely to the extent such Investor shall have been  determined
by final judgment of a court of competent  jurisdiction,  not subject to further
appeal (x) to have breached the  obligation of such Investor  under Section 1(b)
of the Warrants to purchase  Warrant Notes in accordance  with the terms of such
Warrants  and (y) to have  breached  such  obligation  principally  by reason of
conduct of such Investor involving gross negligence or willful

                                      -33-
<PAGE>

misconduct.  Such indemnity shall remain in full force and effect  regardless of
any  investigation  made by or on behalf  of the  Indemnified  Person  and shall
survive the transfer of the Registrable Securities by the Investors.

         (2) In connection with the Registration Statement,  each Investor whose
Registrable  Securities  are included in the  Registration  Statement  agrees to
indemnify and hold harmless, to the same extent and in the same manner set forth
in Section  9(a)(1),  each  Indemnified  Party against any Claim to which any of
them may become subject, under the 1933 Act, the 1934 Act or otherwise,  insofar
as such Claim arises out of or is based upon any Violation,  in each case to the
extent (and only to the extent) that such Violation  occurs in reliance upon and
in conformity with written information furnished to the Company by such Investor
expressly  for use in  connection  with  the  Registration  Statement;  and such
Investor will reimburse any legal or other expenses  reasonably incurred by them
in connection with investigating or defending any such Claim; provided, however,
that the indemnity  agreement  contained in this Section 9(a)(2) shall not apply
to  amounts  paid in  settlement  of any Claim if such  settlement  is  effected
without the prior written  consent of such Investor,  which consent shall not be
unreasonably withheld;  provided,  further,  however, that the Investor shall be
liable  under this  Section  9(a)(2)  for only that  amount of all Claims in the
aggregate as does not exceed the amount by which the  proceeds to such  Investor
as a result of the sale of Registrable  Securities  pursuant to the Registration
Statement  exceeds  the  amount  paid  by such  Investor  for  such  Registrable
Securities.  Such indemnity shall remain in full force and effect  regardless of
any  investigation  made by or on  behalf  of such  Indemnified  Party and shall
survive  the  transfer  of  the   Registrable   Securities  by  the   Investors.
Notwithstanding  anything to the contrary contained herein, the  indemnification
agreement  contained  in this Section  9(a)(2)  with respect to any  preliminary
prospectus shall not inure to the benefit of any Indemnified Party if the untrue
statement or omission of material fact contained in the  preliminary  prospectus
was  corrected  on a  timely  basis  in  the  Prospectus,  as  then  amended  or
supplemented.

         (3) Promptly  after  receipt by an  Indemnified  Person or  Indemnified
Party  under  this  Section  9(a) of notice of the  commencement  of any  action
(including any  governmental  action),  such  Indemnified  Person or Indemnified
Party  shall,  if a  Claim  in  respect  thereof  is  to  be  made  against  any
indemnifying  party under this Section 9(a), deliver to the indemnifying party a
notice of the  commencement  thereof and the  indemnifying  party shall have the
right to participate in, and, to the extent the  indemnifying  party so desires,
jointly with any other indemnifying  party similarly noticed,  to assume control
of the defense thereof with counsel  reasonably  satisfactory to the Indemnified
Person or the Indemnified Party, as the case may be; provided,  however, that an
Indemnified  Person or Indemnified  Party shall have the right to retain its own
counsel with the fees and expenses to be paid by the indemnifying  party, if, in
the  reasonable  opinion of counsel  retained  by the  indemnifying  party,  the
representation  by such counsel of the Indemnified  Person or Indemnified  Party
and the  indemnifying  party would be  inappropriate  due to actual or potential
differing interests between such Indemnified Person or Indemnified Party and any
other party  represented by such counsel in such proceeding;  provided  further,
however,  that no  indemnifying  person  shall be  responsible  for the fees and
expenses  of more than one  separate  counsel  for all  Indemnified  Persons  or
Indemnified  Parties,  as the case may be, hereunder and one separate counsel in
each  jurisdiction  in which a Claim is pending or  threatened.  The  failure to
deliver  notice  to the  indemnifying  party  within  a  reasonable  time of the
commencement of any such action shall not relieve such indemnifying party of any
liability  to the  Indemnified  Person or  Indemnified  Party under this Section
9(a),  except to the extent that the  indemnifying  party is  prejudiced  in its
ability to defend such action.

                                      -34-
<PAGE>

The  indemnification  required  by this  Section  9(a) shall be made by periodic
payments  of the  amount  thereof  during  the  course of the  investigation  or
defense,  as such expense,  loss, damage or liability is incurred and is due and
payable.

         (b) Contribution.  To the extent any indemnification by an indemnifying
party as set  forth in  Section  9(a)  above is  applicable  by its terms but is
prohibited or limited by law, the indemnifying  party agrees to make the maximum
contribution  with respect to any amounts for which it would otherwise be liable
under Section 9(a) to the fullest extent  permitted by law. In  determining  the
amount of contribution to which the respective parties are entitled, there shall
be considered the relative fault of each party, the parties' relative  knowledge
of and access to  information  concerning  the matter with  respect to which the
Claim was  asserted,  the  opportunity  to correct and prevent any  statement or
omission  and  any  other  equitable   considerations   appropriate   under  the
circumstances;  provided,  however, that (a) no contribution shall be made under
circumstances  where the maker  would not have been  liable for  indemnification
under the fault  standards  set forth in Section  9(a),  (b) no Person guilty of
fraudulent  misrepresentation  (within the meaning of Section  11(f) of the 1933
Act) shall be entitled to contribution  from any other Person who was not guilty
of such fraudulent  misrepresentation  and (c) the contribution by any seller of
Registrable  Securities  in  respect  of all  Claims in the  aggregate  shall be
limited to the amount by which the  proceeds  received  by such  seller from the
sale of such Registrable Securities exceeds the amount paid by such Investor for
such Registrable Securities.

         (c) Other Rights. The indemnification and contribution provided in this
Section  shall be in addition to any other rights and remedies  available at law
or in equity.

         10. MISCELLANEOUS.

         (a) Governing Law. THIS AGREEMENT  SHALL BE GOVERNED BY AND INTERPRETED
IN ACCORDANCE WITH THE LAWS OF THE STATE OF CALIFORNIA.

         (b) Headings. The headings,  captions and footers of this Agreement are
for  convenience  of  reference  and  shall  not form  part of,  or  affect  the
interpretation of, this Agreement.

         (c)  Severability.  If any provision of this Agreement shall be invalid
or unenforceable in any jurisdiction,  such invalidity or unenforceability shall
not affect the validity or  enforceability of the remainder of this Agreement or
the validity or enforceability of this Agreement in any other jurisdiction.

         (d)  Notices.  Any notices  required or permitted to be given under the
terms of this Agreement shall be in writing and shall be sent by mail,  personal
delivery,  by  telephone  line  facsimile  transmission  or courier and shall be
effective five days after being placed in the mail, if mailed,  or upon receipt,
if delivered personally, by telephone line facsimile transmission or by courier,
in each case  addressed to a party at such party's  address (or  telephone  line
facsimile  transmission  number) shown in the  introductory  paragraph or on the
signature  page of this  Agreement  or such other  address  (or  telephone  line
facsimile  transmission  number) as a party shall have provided by notice to the
other party in accordance with this provision.  In the case of any notice to the
Company,  such notice shall be addressed to the Company at its address  shown in
the introductory paragraph of this Agreement,  Attention:  Senior Vice 

                                      -35-
<PAGE>

President and Chief Financial  Officer  (telephone  line facsimile  number (650)
553-8310), and a copy shall also be given to: Cooley Godward LLP, 3000 El Camino
Real, Five Palo Alto Square,  Palo Alto,  California 94306,  Attention:  Alan C.
Mendelson,  Esq., and Suzanne  Sawochka Hooper,  Esq.  (telephone line facsimile
transmission number (650) 857-0663), and in the case of any notice to the Buyer,
a copy shall be given to: [__________________________] (telephone line facsimile
transmission  number  [____________]),  in  each  case  with a copy  to:  Diaz &
Altschul  Capital,  LLC, 745 Fifth Avenue,  Suite 1710, New York, New York 10151
(telephone line facsimile transmission number (212) 751-5757).

         (e) Counterparts. This Agreement may be executed in counterparts and by
the parties hereto on separate counterparts, each of which shall be deemed to be
an  original  but all of  which  together  shall  constitute  one  and the  same
instrument.  A telephone line facsimile transmission of this Agreement bearing a
signature  on behalf of a party hereto shall be legal and binding on such party.
Although  this  Agreement  is dated as of the date  first set forth  above,  the
actual date of  execution  and  delivery of this  Agreement by each party is the
date set forth below such party's  signature on the signature  page hereof.  Any
reference in this Agreement or in any of the documents executed and delivered by
the  parties  hereto in  connection  herewith to (1) the date of  execution  and
delivery of this  Agreement by the Buyer shall be deemed a reference to the date
set forth below the Buyer's signature on the signature page hereof, (2) the date
of  execution  and delivery of this  Agreement by the Company  shall be deemed a
reference to the date set forth below the  Company's  signature on the signature
page hereof and (3) the date of execution and delivery of this Agreement, or the
date of execution  and delivery of this  Agreement by the Buyer and the Company,
shall be deemed a  reference  to the  later of the  dates  set  forth  below the
signatures of the parties on the signature page hereof.

         (f) Entire Agreement;  Benefit. This Agreement,  including the Annexes,
Schedules and Disclosure Schedule,  constitutes the entire agreement between the
parties  hereto  with  respect  to  the  subject  matter  hereof.  There  are no
restrictions,  promises, warranties, or undertakings, other than those set forth
or  referred to herein and  therein.  This  Agreement,  including  the  Annexes,
Schedules  and  Disclosure   Schedule,   supersedes  all  prior  agreements  and
understandings, whether written or oral, between the parties hereto with respect
to the subject matter hereof. This Agreement and the terms and provisions hereof
are for the sole  benefit of only the  Company,  the Buyer and their  respective
successors  and  permitted  assigns  and in no event  shall the  Buyer  have any
liability  to any  stockholder  or creditor  of the Company or any other  Person
(other than the Company) in any way  relating to or arising from this  Agreement
or the transactions contemplated hereby.

         (g) Waiver.  Failure of any party to exercise any right or remedy under
this  Agreement or otherwise,  or delay by a party in  exercising  such right or
remedy, or course of dealing between the parties,  shall not operate as a waiver
thereof or an amendment hereof,  nor shall any single or partial exercise of any
such right or power,  or any abandonment or  discontinuance  of steps to enforce
such a right or  power,  preclude  any  other or  further  exercise  thereof  or
exercise of any other right or power.

         (h)  Amendment.  No  amendment,   modification,  waiver,  discharge  or
termination  of any provision of this  Agreement nor consent to any departure by
the Buyer or the Company  therefrom  shall in any event be effective  unless the
same shall be in writing and signed by the party to be charged with enforcement,
and then shall be effective  only in the

                                      -36-
<PAGE>

specific  instance  and for the  purpose for which  given.  No course of dealing
between the parties hereto shall operate as an amendment of this Agreement.

         (i) Further  Assurances.  Each party to this Agreement will perform any
and all acts and execute any and all  documents as may be  necessary  and proper
under the  circumstances in order to accomplish the intents and purposes of this
Agreement and to carry out its provisions.

         (j)  Assignment  of Certain  Rights and  Obligations.  The rights of an
Investor  under Sections  5(a),  5(b), 8, 9, and 10 of this  Agreement  shall be
automatically  assigned by such Investor to any transferee of all or any portion
of such  Investor's  Registrable  Securities (or all or any portion of any Note,
Warrant,  Warrant Note, or Common Stock Warrant) who is an "accredited investor"
as that term is defined in  Regulation  D under the 1933 Act,  only if: (1) such
Investor  agrees in writing with such  transferee  to assign such rights,  and a
copy of such  agreement  is furnished  to the Company  within a reasonable  time
after such  assignment,  (2) the Company is, within a reasonable time after such
assignment, furnished with notice of (A) the name and address of such transferee
and (B) the  Securities  with respect to which such rights and  obligations  are
being  transferred,  (3)  immediately  following such transfer or assignment the
further  disposition of Registrable  Securities by such transferee is restricted
under the 1933 Act and applicable  state  securities  laws, (4) at or before the
time the Company received the notice contemplated by clause (2) of this sentence
the  transferee  agrees in  writing  with the  Company to be bound by all of the
provisions  contained  in  Sections  5(a),  5(b),  8, 9, and 10  hereof  and (5)
immediately  after such transfer such transferee holds at least 25,000 shares of
Common  Stock or a  portion  (which,  if  applicable,  may be all) of any  Note,
Warrant,  Warrant  Note,  or  Common  Stock  Warrant  which  at the time of such
transfer is convertible  into or  exercisable  for 25,000 shares of Common Stock
(or any  combination  thereof)  or such lesser  amount of Common  Stock that any
Note,  Warrant,  Warrant Note, or Common Stock  Warrant is  convertible  into or
exercisable for at the time of such assignment.  Upon any such  assignment,  the
Company  shall be obligated to such  transferee  to perform all of its covenants
under Sections 5, 8, 9, and 10 of this Agreement as if such  transferee were the
Buyer.  In connection with any such transfer the Company shall, at its sole cost
and  expense,  promptly  after  such  assignment  take such  actions as shall be
reasonably acceptable to the transferring Investor and such transferee to assure
that the Registration  Statement relating to the Registrable Securities involved
in such transfer and the Prospectus are available for use by such transferee for
sales of the  Registrable  Securities  in  respect  of  which  such  rights  and
obligations have been so transferred.

         (k) Expenses.  All  reasonable  expenses  incurred in  connection  with
registrations,  filings or  qualifications  pursuant to this Agreement  shall be
paid by the Company,  including,  without limitation, all registration,  listing
and  qualifications  fees,  printers  fees,  accounting  fees,  and the fees and
disbursements  of counsel for the Company but excluding (a) fees and expenses of
investment bankers retained by any Investor,  (b) brokerage commissions incurred
by any Investor and (c) fees and disbursements of counsel for the Investors. The
Company  shall pay on demand  all  expenses  incurred  by the  Buyer,  including
reasonable  fees and  disbursements  of  counsel,  as a  consequence  of,  or in
connection  with (1) any default or breach of any of the  Company's  obligations
set forth in the Transaction  Documents and (2) the enforcement or restructuring
of any right of,  including the  collection of any payments due, the Buyer under
the Transaction  Documents,  including any action or proceeding relating to such
enforcement  or any order,  injunction or other process  seeking to restrain the
Company from

                                      -37-
<PAGE>

paying any amount due the Buyer.  Except as  otherwise  provided in this Section
10(k),  each of the  Company  and the  Buyer  shall  bear  its own  expenses  in
connection with this Agreement and the transactions contemplated hereby. Nothing
herein  shall  limit the  rights of the  Placement  Agent  under its  Engagement
Agreement with the Company.

         (l)  Termination.  The Buyer  shall  have the right to  terminate  this
Agreement by giving notice to the Company at any time at or prior to the Closing
Date if:

         (1) the Company shall have failed,  refused, or been unable at or prior
to the  date of  such  termination  of  this  Agreement  to  perform  any of its
obligations hereunder;

         (2) any other  condition  of the Buyer's  obligations  hereunder is not
fulfilled; or

         (3) the closing  shall not have occurred on a Closing Date on or before
March 31, 1999, other than solely by reason of a breach of this Agreement by the
Buyer.

Any such termination shall be effective upon the giving of notice thereof by the
Buyer. Upon such termination,  the Buyer shall have no further obligation to the
Company  hereunder  and the Company  shall remain  liable for any breach of this
Agreement or the other documents  contemplated hereby which occurred on or prior
to the date of such termination.

         (m) Survival. The respective representations, warranties, covenants and
agreements  of the Company and the Buyer  contained  in this  Agreement  and the
documents  delivered  in  connection  with  this  Agreement  shall  survive  the
execution and delivery of this Agreement and the closing  hereunder and delivery
of and payment  for the Notes and  issuance of the  Warrants,  and shall  remain
operative and in full force and effect regardless of any  investigation  made by
or on behalf of the Buyer or any Person  controlling  or acting on behalf of the
Buyer or by the  Company  or any Person  controlling  or acting on behalf of the
Company.

         (n) Public Statements,  Press Releases,  Etc. The Company and the Buyer
shall have the right to approve before  issuance any press releases or any other
public  statements  with  respect  to  the  transactions   contemplated  hereby;
provided,  however,  that the  Company  shall be  entitled,  without  the  prior
approval of the Buyer, to make any press release or other public disclosure with
respect to such  transactions as is required by applicable law and  regulations,
including  the 1933 Act and the rules  and  regulations  promulgated  thereunder
(although  the Buyer shall be  consulted by the Company in  connection  with any
such press release or other public  disclosure prior to its release and shall be
provided with a copy thereof).

         (o) Construction. The language used in this Agreement will be deemed to
be the language  chosen by the parties to express  their mutual  intent,  and no
rules of strict construction will be applied against any party.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]


                                      -38-
<PAGE>

                  IN WITNESS WHEREOF,  the parties have caused this Agreement to
be duly executed by their  respective  officers  thereunto duly authorized as of
the date first set forth above and on the dates set forth below their respective
signatures.



Principal Amount of Purchase Note:          $

Purchase Price of Purchase Note:            $

Exchange Ratio:   Exchange Note having a principal  amount equal to ________% of
                  the  principal   amount  of  the  Outstanding   Note  that  is
                  outstanding on the Exchange Date


                                  SUGEN, INC.


                                  By:___________________________________________
                                      Name:
                                      Title:

                                  Date:  March   19, 1999

                                  [BUYER]



                                  By:___________________________________________
                                      Name:
                                      Title:

                                  Address:

                                      Attention:

                                  Facsimile No:

                                  Date: March 19, 1999



                                      -39-


THIS NOTE HAS NOT BEEN  REGISTERED  UNDER THE SECURITIES ACT OF 1933, AS AMENDED
(THE "1933 ACT"),  OR ANY STATE  SECURITIES  LAWS. THE ISSUANCE TO THE HOLDER OF
THIS NOTE OF THE SHARES OF COMMON STOCK  ISSUABLE UPON  CONVERSION OF THIS NOTE,
IN PAYMENT OF INTEREST ON THIS NOTE AND UPON  EXERCISE OF COMMON STOCK  WARRANTS
ISSUABLE  UPON  REDEMPTION  OF THIS  NOTE  ARE  NOT  COVERED  BY A  REGISTRATION
STATEMENT UNDER THE 1933 ACT OR REGISTRATION  UNDER STATE  SECURITIES LAWS. THIS
NOTE HAS BEEN ACQUIRED FOR INVESTMENT  ONLY AND MAY NOT BE SOLD,  TRANSFERRED OR
ASSIGNED UNLESS (1) THE RESALE HEREOF IS REGISTERED  UNDER THE 1933 ACT, (2) THE
COMPANY HAS  RECEIVED  AN OPINION OF COUNSEL  REASONABLY  SATISFACTORY  IN FORM,
SCOPE AND SUBSTANCE TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED OR (3)
SOLD, TRANSFERRED OR ASSIGNED TO A QIB PURSUANT TO RULE 144A.

SUCH SHARES OF COMMON STOCK MAY NOT BE SOLD,  TRANSFERRED OR ASSIGNED UNLESS (1)
THE  RESALE  THEREOF IS  REGISTERED  UNDER THE 1933 ACT OR (2) THE  COMPANY  HAS
RECEIVED  AN OPINION  OF  COUNSEL  REASONABLY  SATISFACTORY  IN FORM,  SCOPE AND
SUBSTANCE TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED.

THIS NOTE IS ISSUED  PURSUANT TO A SECURITIES  PURCHASE AND EXCHANGE  AGREEMENT,
DATED AS OF MARCH 19, 1999,  BY AND BETWEEN THE COMPANY AND THE ORIGINAL  HOLDER
OF THIS NOTE, AS AMENDED FROM TIME TO TIME, AND THE HOLDER OF THIS NOTE AND THIS
NOTE ARE SUBJECT TO CERTAIN OF THE TERMS OF THE SECURITIES PURCHASE AND EXCHANGE
AGREEMENT.

THIS NOTE MAY NOT BE TRANSFERRED EXCEPT AS PROVIDED IN SECTION 8.7.


                                   SUGEN, INC.

                      12% SENIOR CONVERTIBLE NOTE DUE 2002

No. ___                                                          $______________
New York, New York
March       24, 1999

         FOR VALUE RECEIVED,  SUGEN, INC., a Delaware  corporation  (hereinafter
called   the   "Company"),   hereby   promises   to   pay   to   [HOLDER],   c/o
__________________________________,  or  registered  assigns  (the  "Holder") or
order,     the     sum    of     ___________________________________     Dollars
($________________),  on the  Maturity  Date,  and to pay interest on the unpaid
principal balance hereof at the Applicable Rate from the date hereof,  until the
same becomes due and  payable,  whether at maturity or upon  acceleration  or by
repurchase  in  accordance  with the terms  hereof or  otherwise.  Any amount of
principal  of or  interest  on this Note  which is not paid when due shall  bear
interest at the Default  Rate from the due date  thereof  until the same is paid
("Default  Interest").  Interest  shall be payable  in arrears on each  Interest
Payment Date, commencing on July 1, 1999, on the principal amount outstanding on
such date.  Interest  on this Note shall be  computed  on the basis of a 360-day
year of 12 30-day months and actual days elapsed.  No interest  shall be payable
on an Interest  Payment Date on any portion of the principal amount of this Note
which shall have

<PAGE>

been  converted or redeemed  prior to such Interest  Payment Date so long as the
Company  shall have complied in full with its  obligations  with respect to such
conversion or redemption.

         All payments of principal of and premium,  if any, and interest on this
Note shall be made in lawful money of the United  States of America,  or, at the
option of the  Company  and  subject to the  provisions  of this Note,  interest
payable on the Interest  Payment  Dates may be paid in whole or in part in fully
paid and  nonassessable  shares of Common Stock. All cash payments shall be made
by wire transfer of  immediately  available  funds to such account as the Holder
may from  time to time  designate  by  written  notice  in  accordance  with the
provisions of this Note. Whenever any amount expressed to be due by the terms of
this Note is due on any day which is not a Business  Day, the same shall instead
be due on the next  succeeding  day which is a Business  Day and, in the case of
any  Interest  Payment  Date which is not the date on which this Note is paid in
full,  the extension of the due date thereof shall not be taken into account for
purposes  of  determining  the  amount of  interest  due on such  date.  Certain
capitalized terms used in this Note are defined in Article VI.

         The  obligations  of the Company under this Note shall rank in right of
payment on a parity with all other unsubordinated obligations of the Company for
indebtedness for borrowed money or the purchase price of property.  This Note is
issued pursuant to the Securities Purchase Agreement and the Holder of this Note
and this Note are subject to the terms of the Securities Purchase Agreement.

         The following terms shall apply to this Note:

                                    ARTICLE I

                      INTEREST IN COMMON STOCK; REDEMPTION

         1.1  Issuance  of  Common  Stock in Lieu of Cash  Interest.  (a) If the
Company  exercises  its option to make a payment of interest on this Note wholly
or partly in shares of Common Stock (herein  sometimes called the "Stock Payment
Option"),  the  issuance  of  Interest  Shares  upon such  exercise of the Stock
Payment Option shall have been authorized by the Board of Directors.

                      (b)  The Company  shall not be  permitted  to exercise the
Stock Payment Option with respect to any payment of interest on this Note if:

                           (i) the number of shares of Common Stock  authorized,
unissued and  unreserved for all purposes other than payment of interest on this
Note, or held in the  Company's  treasury,  after taking into account  shares of
Common Stock  required to be reserved  for  conversion  of this Note,  the Other
Notes and the Warrant  Notes and  exercise  of the  Warrants,  the Common  Stock
Warrants and the Other Common Stock Warrants, is insufficient to pay the portion
of such interest to be paid in Common Stock;

                           (ii) the  issuance or delivery of Interest  Shares or
the  public  resale  of  such  Interest  Shares  by  the  Holder  would  require
registration or filing with or approval of any governmental  authority under any
law or  regulation,  and such  registration,  filing  or  approval  has not been
effected  or  obtained  or is not in effect  or the  Registration  Statement  is
unavailable  for  use by the  Holder  for the  resale  of the  Interest  Shares;
provided,  however,  that with respect to compliance with the securities or blue
sky laws of the states of the United  States,  the

                                      -2-
<PAGE>

requirements of this clause (ii) shall be deemed  satisfied if at the applicable
time the Company is in compliance  with Section 8(b) of the Securities  Purchase
Agreement;

                           (iii) the  Interest  Shares  shall not at the time of
issuance have been authorized for listing,  upon official notice of issuance, on
the principal  securities  exchange on which the Common Stock is then listed and
traded;

                           (iv) the Interest Share Price for the Interest Shares
is less than the par value of
the Common Stock;

                           (v)  an  Event  of  Default  has   occurred   and  is
continuing on the applicable  Interest Payment Date or at any time thereafter to
and including the date on which the Company delivers such Interest Shares to the
Holder; or

                           (vi)  the  Common  Stock is  neither  (i)  listed  or
admitted  for  trading  on a national  securities  exchange  nor (ii)  quoted on
Nasdaq.

                     (c)   (1)  The  Company  shall  have the right to elect the
Stock Payment Option for this Note with respect to a particular Interest Payment
Date only if (A) the Company  gives notice of such  election to the Holder on or
before such  Interest  Payment  Date and (B) the Company also elects the similar
option  which it has with  respect to the Other Notes and the Warrant  Notes for
the interest due thereon on the date which is such Interest  Payment Date and in
each such case  described in this clause (B) pro rata among this Note, the Other
Notes and the Warrant  Notes,  based on the amounts of interest due on such date
hereon and thereon.  If the Company elects the Stock Payment Option with respect
to a particular  Interest Payment Date, the Company shall issue to the Holder in
respect of such Interest  Payment Date the  aggregate  number of whole shares of
Common Stock  determined by dividing the per share  Interest  Share Price of the
Common Stock on the applicable Interest Payment Date into an amount equal to the
total  amount of lawful money of the United  States of America  which the Holder
would  receive if the  aggregate  amount of interest on this Note which is being
paid in Interest Shares were being paid in such lawful money.

                           (2) If the Company  elects the Stock  Payment  Option
with respect to an Interest  Payment Date, the Interest Shares for such Interest
Payment Date shall become issuable on such Interest Payment Date and the Company
shall  deliver,  or cause to be delivered,  the  appropriate  number of Interest
Shares to the Holder  within three  Trading Days after the  applicable  Interest
Payment  Date.  If in any case the Company  shall fail to deliver or cause to be
delivered such number of Interest  Shares to the Holder within five Trading Days
after such Interest Payment Date, then in addition to any other  liabilities the
Company may have hereunder and under applicable law (A) the Company shall pay or
reimburse  the  Holder  on demand  for all  out-of-pocket  expenses,  including,
without limitation,  reasonable fees and expenses of legal counsel,  incurred by
the Holder as a result of such  failure,  (B) if as a result of such failure the
Holder  shall  suffer  any  direct  damages  or  liabilities  from such  failure
(including,  without  limitation,  margin  interest  and the cost of  purchasing
securities  to cover a sale  (whether by the Holder or the  Holder's  securities
broker) or  borrowing  of shares of Common  Stock by the Holder for  purposes of
settling any trade involving a sale of shares of Common Stock made by the Holder
during the period  beginning on the applicable  Interest Payment Date and ending
on the date the  Company  delivers or causes to be  delivered  to the Holder the
Interest Shares issuable in respect thereof), then the Company shall upon demand
of the  Holder  pay  to the  Holder  an  amount  equal  to  the  actual  direct,
out-of-pocket  damages and liabilities  suffered by the Holder by reason thereof
which the Holder  documents to the reasonable  satisfaction of the 

                                      -3-
<PAGE>

Company,  and (C) the Holder may by written  notice (which may be given by mail,
courier,  personal  service or telephone  line facsimile  transmission)  or oral
notice (promptly  confirmed in writing),  given at any time prior to delivery to
the  Holder of the  shares of Common  Stock  issuable  in  connection  with such
exercise of the Stock Payment Option, require payment in cash of the interest in
respect of which the Company  exercised the Stock Payment Option,  in which case
the amount of such interest shall be immediately  due and payable,  with Default
Interest  thereon from the applicable  Interest  Payment Date until paid in full
and upon such cash  payment in full the Company  shall not be obligated to issue
such Interest  Shares to the Holder.  Notwithstanding  the foregoing the Company
shall not be liable to the Holder under clause (B) of the immediately  preceding
sentence  to the extent the  failure of the Company to deliver or to cause to be
delivered such Interest  Shares  results from fire,  flood,  storm,  earthquake,
shipwreck,  strike,  war, acts of  terrorism,  crash  involving  facilities of a
common  carrier,  acts of God, or any similar  event  outside the control of the
Company  (it being  understood  that the action or failure to act of the Issuing
Agent shall not be deemed an event outside the control of the Company  except to
the extent resulting from fire, flood,  storm,  earthquake,  shipwreck,  strike,
war, acts of terrorism,  crash involving facilities of a common carrier, acts of
God, the bankruptcy,  liquidation or  reorganization  of the Issuing Agent under
any bankruptcy, insolvency or other similar law or any similar event outside the
control of the Issuing  Agent).  The Holder  shall notify the Company in writing
(or by telephone conversation,  confirmed in writing) as promptly as practicable
following the third  Trading Day after such Interest  Payment Date if the Holder
becomes  aware  that  Interest  Shares so  issuable  have not been  received  as
provided  herein,  but any failure so to give such  notice  shall not affect the
Holder's rights under this Note or otherwise.

                           (3) No  fractional  shares of Common  Stock  shall be
issued in payment of interest on this Note. In lieu thereof, the Company may, at
its option,  issue a number of shares of Common Stock which  reflects a rounding
up to the next  whole  number of shares or may pay  lawful  money of the  United
States of America in payment of the amount of such  interest in lieu of issuance
of such fractional share.

                           (4) If the Company  elects the Stock  Payment  Option
with  respect to a payment of interest on this Note with respect to a particular
Interest  Payment  Date and the  arithmetic  average of the Market  Price of one
share of Common Stock during the Interest Shares Measurement Period with respect
to such  Interest  Payment Date is less than the  Interest  Share Price for such
Interest  Payment  Date,  then the Company  shall pay to the Holder an amount in
cash determined as follows:

                     PA   =   I   -   (IS   x   M)

where:

               PA    =    the  amount  payable  by the  Company to the Holder in
                          respect of such Interest Payment Date pursuant to this
                          Section 1.1(c)(4)

               I     =    the amount of  interest  payable to the Holder on such
                          Interest  Payment Date in respect of which the Company
                          elected the Stock Payment Option

               IS    =    the number of Interest  Shares issued to the Holder in
                          respect of such Interest Payment Date

                                      -4-
<PAGE>

               M     =    the  arithmetic  average  of the  Market  Price of one
                          share of  Common  Stock  during  the  Interest  Shares
                          Measurement  Period  with  respect  to  such  Interest
                          Payment Date

The amount,  if any, payable by the Company  pursuant to this Section  1.1(c)(4)
shall be deemed to be additional  interest on this Note and shall be paid to the
Holder in lawful money of the United  States of America  within  three  Business
Days after the end of the applicable  Interest Shares Measurement Period by wire
transfer of immediately available funds to such account as shall be specified by
notice from the Holder to the Company from time to time.

                      (d) If the Company  elects the Stock  Payment  Option with
respect  to a payment of  interest  on this Note with  respect  to a  particular
Interest  Payment Date, the Company shall deliver to the Holder,  on or prior to
the date on which Interest  Shares for such payment of interest on this Note are
required to be received by the Holder, a Company  Certificate  setting forth (i)
the total amount of the cash  interest  payment to which the Holder is entitled,
(ii) the portion of such interest payment being made in Interest  Shares,  (iii)
the  Interest  Share  Price and the  Market  Price on each  Trading  Day used in
computing the Interest Share Price, (iv) the number of Interest Shares allocable
to such payment,  as  calculated  pursuant to this Section 1.1, (v) any rounding
adjustment  to such  number or any  payment  necessary  to be made  pursuant  to
Section 1.1(c),  (vi) a brief statement of the facts requiring such  adjustment,
and (vii) a brief  statement  that none of the  conditions  set forth in Section
1.1(b) has  occurred and is existing  and that all of the  requirements  of this
Section 1.1 have been met. Such Company Certificate shall be conclusive evidence
of the correctness of the calculation of the number of Interest Shares allocable
to the payments to which such Company Certificate relates and of any adjustments
to such  number  made  pursuant  to this  Section 1.1 in the absence of manifest
error.  On or before the  pertinent  Interest  Payment  Date,  the Company shall
issue,  or cause the Issuing Agent to prepare and issue,  the Interest Shares in
the name of the Holder or its nominee  before  being so delivered by the Company
on such Interest Payment Date.

                      (e) The Interest  Shares,  when issued  pursuant to and in
compliance with this Section 1.1, shall be, and for all purposes shall be deemed
to be, validly issued,  fully paid and nonassessable shares of Common Stock; the
issuance  and  delivery  thereof  has  been in all  respects  authorized  by the
Company;  and the  issuance  thereof,  together  with lawful money of the United
States of  America,  if any,  paid in lieu of  fractional  shares of such Common
Stock and any amount  required  to be paid by the  Company  pursuant  to Section
1.1(c)(4) with respect to such interest  payment,  will be, and for all purposes
shall be deemed to be,  in full  discharge  and  satisfaction  of the  Company's
obligation  to pay the  interest  on this  Note to which  such  Interest  Shares
relate.

         1.2 Optional Redemption.  (a) At any time after the SEC Effective Date,
the  Company  shall have the right on one  occasion  only to redeem this Note in
full  pursuant to this Section 1.2 on the Optional  Redemption  Date, so long as
(x) on the  date the  Optional  Redemption  Notice  is  given  and at all  times
thereafter to and  including  the Optional  Redemption  Date,  the  Registration
Statement is effective  under the 1933 Act and  available  for use by the Holder
for the resale of all shares of Common  Stock  issuable or issued to the Holder,
including,  without limitation, all Interest Shares issued to the Holder, except
as may  otherwise  be agreed by the Holder at any time with  respect to any such
shares of Common Stock, (y) on the date the Optional  Redemption Notice is given
and at all times thereafter to and including the Optional Redemption Date one or
more  registration  statements  under the 1933 Act  covering  the  resale of the
shares of Common Stock  issuable to the Holder upon exercise of the Common Stock
Warrants  issuable  to the  Holder  in  payment  of a  portion  of the  Optional
Redemption 

                                      -5-
<PAGE>

Consideration shall be effective under the 1933 Act and available for use by the
Holder for the resale of such shares of Common Stock and each such  registration
statement shall be expected to remain available for such use for 30 Trading Days
after the Optional  Redemption Date, and (z) on the date the Optional Redemption
Notice is given,  the Company has funds available to pay the cash portion of the
Optional Redemption Consideration.  In order to exercise its right of redemption
under this Section 1.2, the Company shall give the Optional Redemption Notice to
the  Holder  not less  than 45 days or more than 90 days  prior to the  Optional
Redemption  Date.  The  Optional  Redemption  Notice  shall state that:  (1) the
Company is  exercising  its right to redeem  this Note in  accordance  with this
Section 1.2, (2) the amount of the Optional Redemption Consideration and (3) the
Optional  Redemption Date (which, in the case of a redemption in connection with
a proposed  transaction  that would not be  permitted by the terms of this Note,
may be stated as the date which coincides with  completion of such  transaction,
but in no  event  may be  sooner  than 45 days or more  than 90 days  after  the
Optional Redemption Notice is given). Nothing herein shall permit the Company to
exercise its right of redemption  on a basis that is  contingent or  conditioned
upon any event or other matter.  On the Optional  Redemption Date (or such later
date as the  Holder  surrenders  this  Note to the  Company  duly  endorsed  for
transfer) the Company shall (x) pay to or upon the order of the Holder,  by wire
transfer of  immediately  available  funds to such account as shall be specified
for such  purpose by the Holder at least one  Business Day prior to the Optional
Redemption Date, an amount equal to the cash portion of the Optional  Redemption
Consideration  of this Note and (y) issue and  deliver to the Holder the portion
of the Optional  Redemption  Consideration  consisting of Common Stock Warrants,
which will be deemed for all  purposes  to have been issued to the Holder on the
Optional Redemption Date, unless the Company shall have failed to pay the amount
specified in the immediately preceding clause (x) when due.

                      (b) The Company shall not be entitled to give the Optional
Redemption  Notice or to redeem any  portion of this Note with  respect to which
the Holder  has given a  Conversion  Notice on or prior to the date the  Company
gives the Optional Redemption Notice. Notwithstanding the giving of the Optional
Redemption  Notice,  the  Holder  shall be  entitled  to  convert  this  Note in
accordance with the terms of this Note by giving a Conversion Notice at any time
on or prior to the later of (1) the date which is one  Trading  Day prior to the
Optional  Redemption Date and (2) if the Company fails to pay and deliver to the
Holder or  deposit in  accordance  with  Section  8.10 the  Optional  Redemption
Consideration  on or before the Optional  Redemption Date, the date on which the
Company pays and delivers to the Holder or deposits in  accordance  with Section
8.10  the   Optional   Redemption   Consideration.   The   Optional   Redemption
Consideration  set forth in the Optional  Redemption Notice shall be adjusted to
reflect  the  reduced  outstanding  principal  amount of this  Note and  related
accrued interest and Default Interest on the Optional  Redemption Date resulting
from any permitted conversions of this Note after the Optional Redemption Notice
is given.

                      (c)  Redemption  of this Note pursuant to this Section 1.2
shall be made at the same time as a redemption by the Company of all Other Notes
and Warrant Notes that are  outstanding  on the Optional  Redemption  Date.  The
Company shall not redeem any of the Other Notes or Warrant Notes pursuant to the
provisions  thereof  similar to this  Section  1.2 or  repurchase  or  otherwise
acquire  any of the Other  Notes or the  Warrant  Notes  (other than a mandatory
repurchase  pursuant to  provisions  of the Other  Notes and the  Warrant  Notes
comparable  to Article V) unless the Company  offers  simultaneously  to redeem,
repurchase  or  otherwise  acquire  a pro rata  portion  (based  on  outstanding
principal  amount)  of this  Note for cash at the same  unit  price as the Other
Note(s) or Warrant Note(s).

                                      -6-
<PAGE>

         1.3 No Prepayment,  Etc.  Except as  specifically  provided in Sections
1.2, 5.2 and 5.3, this Note may not be prepaid,  redeemed or  repurchased at the
option  of the  Company  prior to the  Maturity  Date.  The  Company  shall  not
repurchase  or  otherwise  acquire any of the Other  Notes or the Warrant  Notes
unless the Company  offers  simultaneously  to redeem,  repurchase  or otherwise
acquire a pro rata  portion  of this Note for cash at the same price per unit of
outstanding principal amount as the Other Note(s) or Warrant Note(s). Nothing in
this Section 1.3 shall limit the Company's rights under Article VI.

                                   ARTICLE II

                                   CONVERSION

         2.1  Right  to  Convert.  Subject  to  and  upon  compliance  with  the
provisions  of this Note,  the Holder of this Note shall have the right,  at the
Holder's option, at any time prior to the close of business on the Maturity Date
(except that if the Holder shall have exercised repurchase rights under Sections
5.1 and 5.2 or Section 5.3 or the Company shall have  exercised  its  redemption
rights under  Section1.2 such  conversion  right shall terminate with respect to
the portion of this Note to be repurchased  or redeemed,  as the case may be, at
the close of business on the last Trading Day prior to the date the Company pays
or deposits in accordance  with Section 8.10 the  applicable  Repurchase  Price,
Registration  Repurchase Price or Optional Redemption  Consideration  unless the
Company  shall default in payment due upon  repurchase or redemption  hereof) to
convert the  principal  amount of this Note,  or any  portion of such  principal
amount which is at least $10,000 (or such lesser  principal  amount of this Note
as shall be outstanding at such time),  plus accrued and unpaid  interest,  into
that  number of fully paid and  non-assessable  shares of Common  Stock (as such
shares  shall then be  constituted)  obtained by dividing (1) the sum of (x) the
principal  amount of this  Note or  portion  thereof  being  converted  plus (y)
accrued and unpaid interest on the portion of the principal  amount of this Note
being  converted to the applicable  Conversion  Date plus (z) accrued and unpaid
Default Interest, if any, on the amount referred to in the immediately preceding
clause (y) to the  applicable  Conversion  Date by (2) the  Conversion  Price in
effect on the applicable  Conversion Date, by giving a Conversion  Notice in the
manner  provided in Section 2.2;  provided,  however,  that, if at any time this
Note is converted in whole or in part  pursuant to this Section 2.1, the Company
does not have  available  for issuance upon such  conversion  as authorized  and
unissued shares or in its treasury at least the number of shares of Common Stock
required to be issued pursuant hereto,  then, at the election of the Holder made
by notice from the Holder to the  Company,  this Note (or  portion  hereof as to
which  conversion has been requested),  to the extent that sufficient  shares of
Common Stock are not then  available  for  issuance  upon  conversion,  shall be
converted  into the right to receive from the Company,  in lieu of the shares of
Common  Stock into which this Note or such  portion  hereof  would  otherwise be
converted  and which the Company is unable to issue,  payment in an amount equal
to the product  obtained by multiplying (x) the number of shares of Common Stock
which the  Company is unable to issue  times (y) the  arithmetic  average of the
Market  Price for the Common  Stock  during the five  consecutive  Trading  Days
immediately prior to the applicable Conversion Date. Any such payment shall, for
all purposes of this Note, be deemed to be a payment of principal plus a premium
equal to the  total  amount  payable  less the  principal  portion  of this Note
converted  as to which such  payment is  required to be made  because  shares of
Common Stock are not then  available  for  issuance  upon such  conversion.  The
Holder is not  entitled  to any  rights of a holder  of Common  Stock  until the
Holder has converted this Note to Common Stock, and only to the extent this Note
is deemed to have been  converted  to Common  Stock  under this  Article II. For
purposes of Sections 2.5 and 2.6, whenever a provision  references the shares of
Common Stock into which this Note (or a portion  hereof) is  convertible  or the
shares of  Common  Stock  

                                      -7-
<PAGE>

issuable upon  conversion of this Note (or a portion hereof) or words of similar
import,  any  determination  required  by such  provision  shall be made as if a
sufficient  number of shares of Common  Stock were then  available  for issuance
upon conversion in full of this Note.

         2.2  Exercise of  Conversion  Privilege;  Issuance  of Common  Stock on
Conversion;  No Adjustment  for Interest or Dividends.  (a) In order to exercise
the  conversion  privilege  with  respect to this Note,  the Holder shall give a
Conversion  Notice (or such other notice which is  acceptable to the Company) to
the Company and the Issuing  Agent or to the office or agency  designated by the
Company  for such  purpose  by notice  to the  Holder.  The  Holder  shall  make
reasonable  efforts to deliver a copy of such Conversion Notice to the Company's
legal counsel when such notice is delivered to the Company and the Issuing Agent
or as soon as practical thereafter, provided that the failure to do so shall not
relieve the Company or the Issuing  Agent of its  obligations  or prejudice  the
Holder's  rights.  A Conversion  Notice may be given by telephone line facsimile
transmission to the numbers set forth on the form of Conversion Notice.

                  (b) As  promptly  as  practicable,  but in no event later than
three Trading Days, after a Conversion  Notice is given, the Company shall issue
and shall  deliver to the  Holder or the  Holder's  designee  the number of full
shares of Common Stock  issuable  upon such  conversion  of this Note or portion
hereof in accordance  with the provisions of this Article and deliver a check or
cash in respect of any fractional interest in respect of a share of Common Stock
arising upon such conversion,  as provided in Section 2.2(f) and, if applicable,
any cash  payment  required  pursuant  to the  proviso to the first  sentence of
Section 2.1 (which  payment,  if any,  shall be paid no later than three Trading
Days after the applicable Conversion Date).

                  (c) Each  conversion of this Note (or portion hereof) shall be
deemed to have been effected on the applicable  Conversion  Date, and the person
in whose name any certificate or  certificates  for shares of Common Stock shall
be  issuable  upon  such  conversion  shall be  deemed  to have  become  on such
Conversion  Date  the  holder  of  record  of the  shares  represented  thereby;
provided,  however,  that if a  Conversion  Date is a date on  which  the  stock
transfer books of the Company shall be closed such conversion  shall  constitute
the person in whose name the  certificates are to be issued as the record holder
thereof for all purposes on the next succeeding day on which such stock transfer
books are open, but such conversion  shall be at the Conversion  Price in effect
on the applicable  Conversion  Date. Upon conversion of this Note or any portion
hereof, the accrued and unpaid interest on this Note (or portion hereof) to (but
excluding)  the  applicable  Conversion  Date  shall be deemed to be paid to the
Holder of this Note  through  receipt of such  number of shares of Common  Stock
issued upon conversion of this Note or portion hereof as shall have an aggregate
Current  Fair  Market  Value  on the  Trading  Day  immediately  preceding  such
Conversion Date equal to the amount of such accrued and unpaid interest.

                  (d) The  Company  shall  notify the Holder of any claim by the
Company of manifest  error in a Conversion  Notice within two Trading Days after
the Holder gives such  Conversion  Notice and no such claim of error shall limit
or delay  performance of the Company's  obligation to issue upon such conversion
the number of shares of Common  Stock  which are not in  dispute.  A  Conversion
Notice  shall be deemed for all purposes to be in proper form unless the Company
notifies the Holder by telephone line facsimile  transmission within two Trading
Days after a  Conversion  Notice has been given  (which  notice from the Company
shall specify all defects in the Conversion  Notice) and any  Conversion  Notice
containing  any such defect shall  nonetheless be effective on the date given if
the Holder  promptly  undertakes to correct all such defects.  The Company shall
not be required  to pay any tax which may be payable in respect of

                                      -8-
<PAGE>

any transfer  involved in the issuance and delivery of shares of Common Stock or
other  securities  or property on  conversion  of this Note in a name other than
that of the Holder,  and the  Company  shall not be required to issue or deliver
any such shares or other  securities or property  unless and until the person or
persons  requesting  the  issuance  thereof  shall have paid to the  Company the
amount of any such tax or shall  have  established  to the  satisfaction  of the
Company  that such tax has been paid.  The Holder shall be  responsible  for the
amount of any  withholding tax payable in connection with any conversion of this
Note.

                  (e) (1) If the Holder shall have given a Conversion  Notice in
accordance  with the terms of this Note,  the Company's  obligation to issue and
deliver the certificates  for Common Stock shall be absolute and  unconditional,
irrespective  of any action or inaction  by the Holder to enforce the same,  any
waiver or consent  with  respect to any  provision  hereof,  the recovery of any
judgment  against any person or any action to enforce  the same,  any failure or
delay in the  enforcement of any other  obligation of the Company to the Holder,
or any setoff,  counterclaim,  recoupment,  limitation  or  termination,  or any
breach or alleged  breach by the Holder or any other person of any obligation to
the Company or any  violation  or alleged  violation of law by the Holder or any
other person,  and irrespective of any other  circumstance which might otherwise
limit such  obligation  of the  Company to the  Holder in  connection  with such
conversion;  provided, however, that nothing herein shall limit or prejudice the
right of the Company to pursue any such claim in any other  manner  permitted by
applicable  law. The  occurrence of an event which requires an adjustment of the
Conversion  Price as  contemplated  by Section  2.3 shall in no way  restrict or
delay the right of the Holder to  receive  certificates  for  Common  Stock upon
conversion  of this Note and the Company shall use its best efforts to implement
such adjustment on terms reasonably  acceptable to the Holder within two Trading
Days of such occurrence.

                      (2) If the  Company  fails to issue and deliver the shares
of Common Stock to the Holder in connection with a particular conversion of this
Note within five Trading Days after the Holder gives the  Conversion  Notice for
such  conversion,  in  addition  to any other  liabilities  the Company may have
hereunder  and under  applicable  law (A) the Company shall pay or reimburse the
Holder on demand for all out-of-pocket expenses,  including, without limitation,
reasonable  fees and  expenses  of legal  counsel,  incurred  by the Holder as a
result of such  failure,  (B) if as a result of such  failure  the Holder  shall
suffer any direct damages or liabilities from such failure  (including,  without
limitation,  margin  interest and the cost of  purchasing  securities to cover a
sale (whether by the Holder or the Holder's  securities  broker) or borrowing of
shares  of  Common  Stock by the  Holder  for  purposes  of  settling  any trade
involving a sale of shares of Common Stock made by the Holder  during the period
beginning  on the Issuance  Date and ending on the date the Company  delivers or
causes to be  delivered  to the Holder  such  shares of Common  Stock,  then the
Company shall upon demand of the Holder pay to the Holder an amount equal to the
actual direct,  out-of-pocket  damages and liabilities suffered by the Holder by
reason thereof which the Holder documents to the reasonable  satisfaction of the
Company,  and (C) the Holder may by written  notice (which may be given by mail,
courier,  personal  service or telephone  line facsimile  transmission)  or oral
notice (promptly  confirmed in writing),  given at any time prior to delivery to
the  Holder of the  shares of Common  Stock  issuable  in  connection  with such
exercise  of the  Holder's  conversion  right,  rescind  such  exercise  and the
Conversion Notice relating thereto, in which case the Holder shall thereafter be
entitled to convert  that  portion of this Note as to which such  exercise is so
rescinded.  Notwithstanding the foregoing the Company shall not be liable to the
Holder under clause (B) of the immediately  preceding sentence to the extent the
failure of the  Company to deliver or to cause to be  delivered  such  shares of
Common Stock results from fire, flood,  storm,  earthquake,  shipwreck,  strike,
war, acts of terrorism,  crash involving facilities of a common carrier, acts of

                                      -9-
<PAGE>

God,  or any  similar  event  outside  the  control  of the  Company  (it  being
understood  that the action or failure to act of the Issuing  Agent shall not be
deemed  an event  outside  the  control  of the  Company  except  to the  extent
resulting from fire, flood, storm, earthquake,  shipwreck,  strike, war, acts of
terrorism,  crash  involving  facilities of a common  carrier,  acts of God, the
bankruptcy,  liquidation  or  reorganization  of the  Issuing  Agent  under  any
bankruptcy,  insolvency  or other  similar law or any similar  event outside the
control of the Issuing  Agent).  The Holder  shall notify the Company in writing
(or by telephone conversation,  confirmed in writing) as promptly as practicable
following  the third  Trading Day after the Holder gives a Conversion  Notice if
the Holder  becomes  aware that such shares of Common Stock so issuable have not
been received as provided  herein,  but any failure so to give such notice shall
not affect the Holder's rights under this Note or otherwise.

                  (f) No fractional  shares of Common Stock shall be issued upon
conversion  of this Note but, in lieu of any fraction of a share of Common Stock
which would otherwise be issuable in respect of such conversion, the Company may
round the number of shares of Common Stock issued on such  conversion  up to the
next highest whole share or may pay lawful money of the United States of America
for such fractional  share,  based on a value of one share of Common Stock being
equal to the Market Price of the Common Stock on the applicable Conversion Date.

         2.3  Adjustment  of Conversion  Price.  The  Conversion  Price shall be
adjusted from time to time by the Company as follows:

                  (a) In case the Company  shall on or after the  Issuance  Date
pay a dividend or make a distribution to all holders of the  outstanding  Common
Stock in shares of Common Stock,  the Conversion  Price in effect at the opening
of  business  on the date  following  the date  fixed for the  determination  of
stockholders  entitled to receive such dividend or other  distribution  shall be
reduced  by  multiplying  such  Conversion  Price by a  fraction  of  which  the
numerator shall be the number of shares of Common Stock outstanding at the close
of business on the Record Date fixed for such  determination and the denominator
shall be the sum of such  number  of  shares  and the  total  number  of  shares
constituting  such  dividend or other  distribution,  such  reduction  to become
effective  immediately  after the opening of business on the day  following  the
Record  Date.  If any  dividend or  distribution  of the type  described in this
Section 2.3(a) is declared but not so paid or made,  the Conversion  Price shall
again be adjusted to the Conversion  Price which would then be in effect if such
dividend or distribution had not been declared.

                  (b) In case the Company  shall on or after the  Issuance  Date
issue  rights or  warrants  (other than any rights or  warrants  (including  the
Preferred Share Purchase  Rights)  referred to in Section 2.3(d)) to all holders
of its outstanding  shares of Common Stock entitling them (for a period expiring
within  45 days  after  the date  fixed for the  determination  of  stockholders
entitled to receive such rights or warrants) to subscribe for or purchase shares
of Common  Stock at a price per share less than the Current  Market Price on the
Record Date fixed for the determination of stockholders entitled to receive such
rights or  warrants,  the  Conversion  Price  shall be adjusted so that the same
shall equal the price  determined by multiplying the Conversion  Price in effect
at the  opening of  business on the date after such Record Date by a fraction of
which the numerator shall be the number of shares of Common Stock outstanding at
the close of  business  on the Record  Date plus the number of shares  which the
aggregate offering price of the total number of shares so offered would purchase
at such Current Market Price, and the denominator  shall be the number of shares
of Common Stock outstanding on the close of business on the Record Date plus the
total number of additional shares of Common 

                                      -10-
<PAGE>

Stock so offered for  subscription  or purchase.  Such  adjustment  shall become
effective  immediately  after the opening of business on the day  following  the
Record Date fixed for  determination  of  stockholders  entitled to receive such
rights or warrants.  To the extent that shares of Common Stock are not delivered
pursuant to such rights or warrants,  upon the expiration or termination of such
rights or warrants,  the Conversion  Price shall be readjusted to the Conversion
Price which would then be in effect had the  adjustments  made upon the issuance
of such rights or warrants been made on the basis of delivery of only the number
of shares of Common Stock actually  delivered.  In the event that such rights or
warrants are not so issued,  the Conversion  Price shall again be adjusted to be
the  Conversion  Price  which would then be in effect if such date fixed for the
determination  of  stockholders  entitled to receive such rights or warrants had
not been fixed. In determining whether any rights or warrants entitle the holder
to  subscribe  for or purchase  shares of Common Stock at less than such Current
Market Price, and in determining the aggregate  offering price of such shares of
Common Stock,  there shall be taken into account any consideration  received for
such rights or warrants, the value of such consideration, if other than cash, to
be determined by the Board of Directors.

                  (c) In case the outstanding shares of Common Stock shall on or
after the Issuance Date be subdivided  into a greater number of shares of Common
Stock,  the Conversion Price in effect at the opening of business on the earlier
of the day following the day upon which such subdivision  becomes  effective and
the day on which "ex-"  trading of the Common  Stock begins with respect to such
subdivision  shall  be  proportionately   reduced,   and  conversely,   in  case
outstanding  shares of Common Stock shall be combined  into a smaller  number of
shares of Common  Stock,  the  Conversion  Price in  effect  at the  opening  of
business on the earlier of the day following the day upon which such combination
becomes  effective  and the day on which "ex-"  trading of the Common Stock with
respect to such  combination  begins shall be  proportionately  increased,  such
reduction or increase, as the case may be, to become effective immediately after
the opening of business on the earlier of the day  following  the day upon which
such  subdivision  or combination  becomes  effective and the day on which "ex-"
trading  of the  Common  Stock  begins  with  respect  to  such  subdivision  or
combination.

                  (d) In case the Company  shall on or after the Issuance  Date,
by dividend or  otherwise,  distribute to all holders of its Common Stock shares
of any class of  capital  stock of the  Company  (other  than any  dividends  or
distributions to which Section 2.3(a) applies) or evidences of its indebtedness,
cash or other assets (including securities, but excluding any rights or warrants
referred to in Section 2.3(b) and dividends and  distributions  paid exclusively
in cash and  excluding any capital  stock,  evidences of  indebtedness,  cash or
assets  distributed upon a merger or consolidation to which Section 2.4 applies)
(the foregoing  hereinafter  in this Section  2.3(d) called the  "Securities")),
then, in each such case, subject to the second paragraph of this Section 2.3(d),
the  Conversion  Price  shall be  reduced so that the same shall be equal to the
price determined by multiplying the Conversion Price in effect immediately prior
to the close of business on the Record Date with respect to such distribution by
a fraction of which the numerator shall be the Current Market Price on such date
less the fair  market  value (as  determined  by the Board of  Directors,  whose
determination  shall be conclusive and described in a Board  Resolution) on such
date of the portion of the Securities so distributed  applicable to one share of
Common  Stock and the  denominator  shall be such  Current  Market  Price,  such
reduction to become  effective  immediately  prior to the opening of business on
the day following the Record Date; provided, however, that in the event the then
fair  market  value (as so  determined)  of the  portion  of the  Securities  so
distributed  applicable to one share of Common Stock is equal to or greater than
the  Current  Market  Price  on the  Record  Date,  in  lieu  of  the  foregoing
adjustment,  adequate  provision shall be made so that the Holder shall have the
right to receive upon conversion of this Note (or any portion hereof) the amount
of  Securities

                                      -11-
<PAGE>

such holder would have received had such holder  converted this Note (or portion
hereof)  immediately  prior to such Record Date. In the event that such dividend
or  distribution  is not so paid or made,  the  Conversion  Price shall again be
adjusted  to be the  Conversion  Price  which  would  then be in  effect if such
dividend  or  distribution  had not been  declared.  If the  Board of  Directors
determines  the fair  market  value of any  distribution  for  purposes  of this
Section  2.3(d) by reference to the actual or when issued trading market for any
Securities  comprising  all or part of such  distribution,  it must in  doing so
consider  the prices in such market over the same period used in  computing  the
Current Market Price to the extent possible.

                  Rights or warrants  distributed  by the Company to all holders
of Common  Stock  entitling  the holders  thereof to  subscribe  for or purchase
shares  of the  Company's  capital  stock  (either  initially  or under  certain
circumstances),  which rights or warrants,  until the  occurrence of a specified
event or events (a "Trigger Event"):  (i) are deemed to be transferred with such
shares of Common Stock;  (ii) are not exercisable;  and (iii) are also issued in
respect of future  issuances of Common  Stock,  shall not be deemed to have been
distributed  for  purposes  of  this  Section  2.3  (and  no  adjustment  to the
Conversion  Price under this Section 2.3 will be required)  until the occurrence
of the earliest  Trigger  Event.  If any such rights or warrants,  including any
such  existing  rights  or  warrants  distributed  prior  to the  Issuance  Date
(including the Preferred Share Purchase Rights),  are subject to Trigger Events,
upon the  satisfaction  of each of which such  rights or warrants  shall  become
exercisable to purchase different securities, evidences of indebtedness or other
assets,  then the  occurrence  of each such Trigger  Event shall be deemed to be
such date of  issuance  and record  date with  respect to new rights or warrants
(and a  termination  or expiration  of the existing  rights or warrants  without
exercise  by the  holder  thereof)  (so  that,  by way of  illustration  and not
limitation,  the dates of issuance of any such rights  shall be deemed to be the
dates on which such rights become  exercisable to purchase  capital stock of the
Company,  and not the date on which such  rights  may be  issued,  or may become
evidenced by separate certificates, if such rights are not then so exercisable).
In addition,  in the event of any  distribution  of rights or  warrants,  or any
Trigger  Event with respect  thereto  (including  the Preferred  Share  Purchase
Rights),  that was counted for purposes of calculating a distribution amount for
which an adjustment to the Conversion  Price under this Section 2.3 was made (1)
in the case of any such rights or warrants which shall all have been redeemed or
repurchased without exercise by any holders thereof,  the Conversion Price shall
be  readjusted  upon such final  redemption or repurchase to give effect to such
distribution  or  Trigger  Event,  as the case may be,  as though it were a cash
distribution,  equal to the per share redemption or repurchase price received by
a holder or holders  of Common  Stock with  respect to such  rights or  warrants
(assuming such holder had retained such rights or warrants), made to all holders
of Common Stock as of the date of such redemption or repurchase,  and (2) in the
case of such rights or warrants  (including the Preferred Share Purchase Rights)
which  shall have  expired or been  terminated  without  exercise by any holders
thereof, the Conversion Price shall be readjusted as if such rights and warrants
had not been issued.

                  For  purposes of this Section  2.3(d) and Sections  2.3(a) and
(b), any dividend or  distribution  to which this Section  2.3(d) is  applicable
that also includes  shares of Common  Stock,  or rights or warrants to subscribe
for or  purchase  shares of Common  Stock to which  Section  2.3(b)  applies (or
both),  shall be deemed  instead to be (1) a  dividend  or  distribution  of the
evidences of indebtedness,  assets,  shares of capital stock, rights or warrants
other than such shares of Common  Stock or rights or  warrants to which  Section
2.3(b)  applies (and any  Conversion  Price  reduction  required by this Section
2.3(d)  with  respect  to such  dividend  or  distribution  shall  then be made)
immediately  followed by (2) a dividend or distribution of such shares of Common
Stock or such rights or warrants  (and any further  Conversion  Price  reduction
required  by  Sections   2.3(a)  and  (b)  with  respect  to  such  dividend  or
distribution shall then be 

                                      -12-
<PAGE>

made),  except (A) the Record  Date of such  dividend or  distribution  shall be
substituted as "the date fixed for the determination of stockholders entitled to
receive  such  dividend  or other  distribution",  "Record  Date  fixed for such
determination"  and "Record  Date"  within the meaning of Section  2.3(a) and as
"the date fixed for the  determination of stockholders  entitled to receive such
rights  or  warrants",  "the  Record  Date  fixed for the  determination  of the
stockholders entitled to receive such rights or warrants" and "such Record Date"
within the meaning of Section 2.3(b) and (B) any shares of Common Stock included
in such dividend or distribution  shall not be deemed  "outstanding at the close
of business on the Record Date fixed for such determination"  within the meaning
of Section 2.3(a).

                  (e) In case the Company  shall on or after the Issuance  Date,
by dividend or  otherwise,  distribute  to all holders of its Common  Stock cash
(excluding any cash that is distributed  upon a merger or consolidation to which
Section 2.4 applies or as part of a distribution  referred to in Section 2.3(d))
in an aggregate amount that, combined with (1) the aggregate amount of any other
such  distributions  to all holders of its Common Stock made exclusively in cash
within the 12 months preceding the date of payment of such distribution,  and in
respect of which no  adjustment  pursuant to this Section  2.3(e) has been made,
and (2) the  aggregate of any cash plus the fair market value (as  determined by
the Board of Directors, whose determination shall be conclusive and set forth in
a Board  Resolution) of consideration  payable in respect of any Tender Offer by
the  Company  or any  Subsidiary  for all or any  portion  of the  Common  Stock
concluded   within  the  12  months  preceding  the  date  of  payment  of  such
distribution,  and in respect of which no adjustment  pursuant to Section 2.3(f)
has been made, exceeds 10% of the product of (x) the Current Market Price on the
Record Date with respect to such distribution  times (y) the number of shares of
Common Stock outstanding on such date, then, and in each such case,  immediately
after the close of business on such date,  unless the Company  elects to reserve
such cash for  distribution  to the Holder upon the conversion of this Note (and
shall have made  adequate  provision)  so that the Holder will receive upon such
conversion,  in  addition  to the shares of Common  Stock to which the Holder is
entitled,  the amount of cash which the Holder would have received if the Holder
had,  immediately  prior  to the  Record  Date for  such  distribution  of cash,
converted this Note into Common Stock,  the Conversion Price shall be reduced so
that the same shall equal the price  determined by  multiplying  the  Conversion
Price in effect  immediately  prior to the close of business on such Record Date
by a fraction (i) the  numerator  of which shall be equal to the Current  Market
Price on the Record Date less an amount  equal to the quotient of (x) the excess
of such  combined  amount  over such 10% and (y) the  number of shares of Common
Stock  outstanding on the Record Date and (ii) the denominator of which shall be
equal to the Current Market Price on the Record Date; provided, however, that in
the event the  portion  of the cash so  distributed  applicable  to one share of
Common Stock is equal to or greater than the Current  Market Price of the Common
Stock  on the  Record  Date,  in  lieu  of the  foregoing  adjustment,  adequate
provision  shall be made so that the Holder shall have the right to receive upon
conversion  of this Note (or any  portion  hereof) the amount of cash the Holder
would have  received  had the Holder  converted  this Note (or  portion  hereof)
immediately  prior to such  Record  Date.  In the event  that such  dividend  or
distribution  is not so paid or  made,  the  Conversion  Price  shall  again  be
adjusted  to be the  Conversion  Price  which  would  then be in  effect if such
dividend or distribution had not been declared.

                  (f) In case a Tender Offer on or after the Issuance  Date made
by the  Company or any  Subsidiary  for all or any  portion of the Common  Stock
shall  expire and such Tender  Offer (as amended  upon the  expiration  thereof)
shall require the payment to  stockholders  (based on the  acceptance (up to any
maximum  specified  in the terms of the Tender  Offer) of  Purchased  Shares (as
defined  below)) of an  aggregate  consideration  having a 

                                      -13-
<PAGE>

fair market value (as determined by the Board of Directors,  whose determination
shall be conclusive and described in a Board  Resolution) that combined together
with (1) the aggregate of the cash plus the fair market value (as  determined by
the Board of Directors, whose determination shall be conclusive and described in
a Board Resolution), as of the expiration of such Tender Offer, of consideration
payable in respect of any other Tender Offers,  by the Company or any Subsidiary
for all or any  portion  of the  Common  Stock  expiring  within  the 12  months
preceding  the  expiration  of such  Tender  Offer  and in  respect  of which no
adjustment  pursuant to this Section  2.3(f) has been made and (2) the aggregate
amount of any  distributions  to all holders of the Company's  Common Stock made
exclusively  in cash within 12 months  preceding  the  expiration of such Tender
Offer and in respect of which no adjustment  pursuant to Section 2.3(e) has been
made, exceeds 10% of the product of the Current Market Price as of the last time
(the  "Expiration  Time")  tenders  could have been made pursuant to such Tender
Offer  (as it may be  amended)  times the  number  of  shares  of  Common  Stock
outstanding (including any tendered shares) at the Expiration Time, then, and in
each such case,  immediately  prior to the  opening of business on the day after
the date of the Expiration  Time, the Conversion Price shall be adjusted so that
the same shall equal the price determined by multiplying the Conversion Price in
effect immediately prior to close of business on the date of the Expiration Time
by a  fraction  of which the  numerator  shall be the number of shares of Common
Stock  outstanding  (including  any  tendered  shares)  at the  Expiration  Time
multiplied  by the Current  Market  Price of the Common Stock on the Trading Day
next succeeding the Expiration Time and the denominator  shall be the sum of (x)
the fair market value  (determined as aforesaid) of the aggregate  consideration
payable to stockholders  based on the acceptance (up to any maximum specified in
the terms of the Tender Offer) of all shares validly  tendered and not withdrawn
as of the  Expiration  Time  (the  shares  deemed  so  accepted,  up to any such
maximum, being referred to as the "Purchased Shares") and (y) the product of the
number of shares of Common Stock  outstanding (less any Purchased Shares) at the
Expiration  Time and the Current Market Price of the Common Stock on the Trading
Day next  succeeding  the  Expiration  Time,  such  reduction (if any) to become
effective  immediately prior to the opening of business on the day following the
Expiration  Time. In the event that the Company is obligated to purchase  shares
pursuant to any such Tender Offer,  but the Company is permanently  prevented by
applicable  law from  effecting  any such  purchases or all such  purchases  are
rescinded,  the  Conversion  Price shall again be adjusted to be the  Conversion
Price which would then be in effect if such Tender  Offer had not been made.  If
the  application  of this Section  2.3(f) to any Tender Offer would result in an
increase in the Conversion  Price,  no adjustment  shall be made for such Tender
Offer under this Section 2.3(f).

                  (g) (1) In case at any time on or after the Issuance  Date the
Company  shall  issue  shares of its Common  Stock or Common  Stock  Equivalents
(collectively,  the "Newly Issued  Shares"),  other than an issuance pro rata to
all holders of its  outstanding  Common Stock, at a price below the Current Fair
Market Value of the Common Stock at the time of such  issuance,  then  following
such issuance of Newly Issued Shares the  Conversion  Price shall be adjusted as
provided  in this  Section  2.3(g).  The  Conversion  Price  following  any such
adjustment shall be determined by multiplying the Conversion  Price  immediately
prior to such adjustment by a fraction,  of which the numerator shall be the sum
of (a) the number of shares of Common Stock outstanding immediately prior to the
issuance  of the  Newly  Issued  Shares  (calculated  on a  fully-diluted  basis
assuming the conversion of all options, warrants, purchase rights or convertible
securities which are exercisable at the time of the issuance of the Newly Issued
Shares)  plus (b) the  number  of shares of  Common  Stock  which the  aggregate
consideration,  if any,  received by the Company for the number of Newly  Issued
Shares  would  purchase at a price equal to the Current Fair Market Value of the
Common Stock at the time of such issuance,  and the denominator shall be the sum
of (X) the number of shares of Common Stock

                                      -14-
<PAGE>

outstanding  immediately  prior  to the  issuance  of the  Newly  Issued  Shares
(calculated on a fully-diluted  basis assuming the exercise or conversion of all
options,   warrants,   purchase  rights  or  convertible  securities  which  are
exercisable  or  convertible  at the time of the  issuance  of the Newly  Issued
Shares) plus (Y) the number of Newly Issued Shares. The adjustment  provided for
in this Section 2.3(g) may be expressed as the following mathematical formula:



     ----------------------------- ------------------------- --------------
                                        ( O +(C / FMV))           x CP
                                        ---------------
     ----------------------------- ------------------------- --------------
                            NCP  =        ( O + N )
     ----------------------------- ------------------------- --------------
where,

               C    =     aggregate  consideration  received  by the Company for
                          the Newly Issued Shares

               N    =     number of Newly Issued Shares

               O    =     number of shares of  Common  Stock  outstanding  (on a
                          fully diluted basis, as described  above)  immediately
                          prior to the issuance of the Newly Issued Shares

               FMV  =     Current  Fair Market  Value of the Common Stock at the
                          time of issuance of the Newly Issued Shares

               CP   =     Conversion Price  immediately prior to the issuance of
                          the Newly Issued Shares

               NCP  =     Conversion Price immediately after the issuance of the
                          Newly Issued Shares

                          (2) Notwithstanding the foregoing, no adjustment shall
be made under this Section 2.3(g) by reason of:

                              (A) the  issuance  by the  Company  of  shares  of
Common  Stock pro rata to all  holders  of the  Common  Stock so long as (i) any
adjustment to the  Conversion  Price that is required by Section  2.3(a) is made
and (ii) the Company  shall have given  notice of such  issuance  thereof to the
Holder pursuant to Section 2.6;

                              (B) the  issuance by the  Company of Newly  Issued
Shares  in an  offering  for  cash  for  the  account  of the  Company  that  is
underwritten on a firm commitment basis and is registered under the 1933 Act;

                              (C) the  issuance by the Company for cash of Newly
Issued  Shares in connection  with a strategic  alliance,  collaboration,  joint
venture,  partnership or similar  arrangement of the Company with another Person
which strategic alliance,  collaboration,  joint venture, partnership or similar
arrangement  relates to the Company's  business as conducted  immediately  prior
thereto  and which  Person is engaged  in a  business  similar or related to the
business of the Company so long as (x) the price per Newly  Issued  Share is not
less than 85 percent of the Current Fair Market Value of the Common Stock on the
date of issuance of such Newly  Issued  Shares and (y) the  consideration  other
than cash which the Company receives in connection with such strategic alliance,
collaboration, joint venture, partnership or similar 

                                      -15-
<PAGE>

arrangement  has a  value,  as  determined  by the  Board  of  Directors  in its
reasonable  judgment and set forth in a Board Resolution,  at least equal to the
amount by which (i) the product of the number of Newly  Issued  Shares so issued
times the Current  Fair Market  Value of the Common Stock on the date such Newly
Issued Shares are issued exceeds (ii) the aggregate cash consideration  received
by the Company for such Newly Issued Shares at the time of issuance thereof;

                              (D) the  issuance  by the  Company of the  Warrant
Notes, the Common Stock Warrants or the Other Common Stock Warrants or shares of
Common Stock upon  conversion of this Note, the Other Notes or the Warrant Notes
or upon exercise of the Common Stock Warrants or the Other Common Stock Warrants
in accordance with the terms hereof and thereof; and

                              (E) the  issuance  by the  Company  of  shares  of
Common  Stock in  payment of  interest  on this  Note,  the Other  Notes and the
Warrant Notes in accordance with the terms hereof and thereof.

                  (h) The Company  may make such  reductions  in the  Conversion
Price,  in addition to those  required by Sections  2.3(a),  (b), (c), (d), (e),
(f),  and (g), as the Board of  Directors  considers to be advisable to avoid or
diminish any income tax to holders of Common Stock or rights to purchase  Common
Stock resulting from any dividend or distribution of stock (or rights to acquire
stock) or from any event treated as such for income tax purposes.

                  (i) No  adjustment in the  Conversion  Price shall be required
unless such  adjustment  would require an increase or decrease of at least 1% in
such price;  provided,  however,  that any  adjustments  which by reason of this
Section  2.3(i) are not  required to be made shall be carried  forward and taken
into account in any subsequent  adjustment.  All calculations under this Article
II shall be made by the Company and shall be made to the nearest  cent or to the
nearest one hundredth of a share, as the case may be.

                  No  adjustment  need be made for a change  in the par value of
the  Common  Stock or from par value to no par value or from no par value to par
value.

                  (j)  Whenever  the  Conversion  Price is  adjusted  as  herein
provided,  the  Company  shall  promptly,  but in no event  later than five days
thereafter, give a notice to the Holder setting forth the Conversion Price after
such  adjustment and setting forth a brief statement of the facts requiring such
adjustment, but which statement shall not include any information which would be
material non-public information for purposes of the 1934 Act. Failure to deliver
such notice shall not affect the legality or validity of any such adjustment.

                  (k) In any case in which this  Section  2.3  provides  that an
adjustment shall become effective  immediately after a Record Date for an event,
the  Company  may defer  until the  occurrence  of such event (i) issuing to the
Holder in connection with any conversion of this Note after such Record Date and
before  the  occurrence  of such  event the  additional  shares of Common  Stock
issuable upon such conversion by reason of the adjustment required by such event
over and above the Common Stock  issuable  upon such  conversion  before  giving
effect to such  adjustment  and (ii) paying to such holder any amount in cash in
lieu of any fraction pursuant to Section 2.2(f).

                  (l) For  purposes of this Section 2.3, the number of shares of
Common  Stock at any time  outstanding  shall  not  include  shares  held in the
treasury of the Company but shall

                                      -16-
<PAGE>

include  shares  issuable  in  respect of scrip  certificates  issued in lieu of
fractions  of shares of Common  Stock.  The Company will not pay any dividend or
make any  distribution  on shares of Common  Stock held in the  treasury  of the
Company  other than (i)  dividends  or  distributions  payable only in shares of
Common Stock and (ii) the Preferred Share Purchase Rights.

         2.4 Effect of Reclassification,  Consolidation,  Merger or Sale. (a) If
any of the following events occur, namely (i) any  reclassification or change of
the  outstanding  shares of Common Stock  (other than a change in par value,  or
from par  value to no par  value,  or from no par  value to par  value,  or as a
result of a  subdivision  or  combination),  (ii) any  consolidation,  merger or
combination of the Company with another corporation as a result of which holders
of Common Stock shall be entitled to receive stock, securities or other property
or assets (including cash) with respect to or in exchange for such Common Stock,
or (iii) any sale or conveyance of the  properties and assets of the Company as,
or substantially  as, an entirety to any other  corporation as a result of which
holders of Common Stock shall be entitled to receive stock,  securities or other
property or assets  (including  cash) with  respect to or in  exchange  for such
Common Stock,  then the Company or the successor or purchasing  corporation,  as
the case may be,  shall  execute with the Holder a written  agreement  providing
that this Note shall be convertible  into the kind and amount of shares of stock
and other securities or property or assets (including cash) receivable upon such
reclassification, change, consolidation, merger, combination, sale or conveyance
by the holder of a number of shares of Common Stock issuable upon  conversion of
this Note immediately  prior to such  reclassification,  change,  consolidation,
merger, combination, sale or conveyance assuming such holder of Common Stock did
not exercise such holder's rights of election,  if any, as to the kind or amount
of  securities,  cash or other  property  receivable  upon  such  consolidation,
merger,  statutory exchange,  sale or conveyance  (provided that, if the kind or
amount of securities, cash or other property receivable upon such consolidation,
merger, statutory exchange, sale or conveyance is not the same for each share of
Common  Stock in respect of which such  rights of  election  shall not have been
exercised  ("non-electing share"), then for the purposes of this Section 2.4 the
kind and  amount of  securities,  cash or other  property  receivable  upon such
consolidation,   merger,   statutory  exchange,  sale  or  conveyance  for  each
non-electing  share shall be deemed to be the kind and amount so receivable  per
share by a plurality of the non-electing  shares).  Such written agreement shall
provide  for  adjustments  which  shall  be  as  nearly  equivalent  as  may  be
practicable to the adjustments  provided for in this Article. If, in the case of
any such reclassification,  change, consolidation,  merger, combination, sale or
conveyance,  the stock or other securities and assets receivable  thereupon by a
holder of shares of Common Stock  includes  shares of stock or other  securities
and assets of a corporation other than the successor or purchasing  corporation,
as the case may be, in such  reclassification,  change,  consolidation,  merger,
combination,  sale or  conveyance,  then such  written  agreement  shall also be
executed by such other corporation and shall contain such additional  provisions
to  protect  the  interests  of the  Holder  as the  Board  of  Directors  shall
reasonably  consider  necessary by reason of the  foregoing,  including,  to the
extent practicable, the provisions providing for the repurchase rights set forth
in Article V herein.

                  (b) The above provisions of this Section shall similarly apply
to successive reclassifications, changes, consolidations, mergers, combinations,
sales and conveyances.

                  (c) If this  Section 2.4  applies to any event or  occurrence,
Section 2.3 shall not apply.

         2.5 Reservation of Shares;  Shares to Be Fully Paid;  Listing of Common
Stock.

                                      -17-
<PAGE>

                  (a) The Company  shall reserve and keep  available,  free from
preemptive  rights, out of its authorized but unissued shares of Common Stock or
shares of Common Stock held in treasury,  solely for issuance upon conversion of
this Note and the Other  Notes,  and in addition  to the shares of Common  Stock
required to be reserved by the terms of the Warrant  Notes,  the  Warrants,  the
Common Stock Warrants, and the Other Common Stock Warrants, sufficient shares to
provide for the conversion of this Note and the Other Notes from time to time as
this Note and the Other Notes are converted.

                  (b) Before  taking any action which would cause an  adjustment
reducing the Conversion Price below the then par value, if any, of the shares of
Common Stock  issuable upon  conversion of this Note,  the Company will take all
corporate action which may, in the opinion of its counsel, be necessary in order
that the Company may validly and legally  issue  shares of such Common  Stock at
such adjusted Conversion Price.

                  (c) The  Company  covenants  that all  shares of Common  Stock
issued upon conversion of this Note will be fully paid and non-assessable by the
Company  and free from all taxes,  liens and charges  with  respect to the issue
thereof.

                  (d) The Company  covenants  that if any shares of Common Stock
to be provided  for the purpose of  conversion  of this Note  hereunder  require
registration with or approval of any governmental authority under any federal or
state law before such shares may be validly issued upon conversion,  the Company
will in good faith and as  expeditiously  as  possible  endeavor  to secure such
registration or approval, as the case may be.

                  (e) The Company  covenants  that,  so long as the Common Stock
shall be  listed  on the  Nasdaq,  the  NYSE or any  other  national  securities
exchange,  the Company shall obtain and, so long as the Common Stock shall be so
listed on such market or exchange,  maintain approval for listing thereon of all
Common Stock issuable upon conversion of or in payment of interest on this Note.

         2.6 Notice to Holder Prior to Certain Actions.  In case on or after the
Issuance Date:

                  (a) the  Company  shall  declare  a  dividend  (or  any  other
distribution) on its Common Stock (other than in cash out of retained earnings);
or

                  (b) the Company shall authorize the granting to the holders of
its Common Stock of rights or warrants to subscribe for or purchase any share of
any class or any other rights or warrants; or

                  (c)   the   Board   of   Directors    shall    authorize   any
reclassification of the Common Stock of the Company (other than a subdivision or
combination of its  outstanding  Common Stock, or a change in par value, or from
par  value  to no par  value,  or  from  no par  value  to  par  value),  or any
consolidation or merger or other business  combination  transaction to which the
Company is a party and for which approval of any  stockholders of the Company is
required,  or the sale or transfer of all or substantially  all of the assets of
the Company; or

                  (d)  there  shall be  pending  the  voluntary  or  involuntary
dissolution, liquidation or winding-up of the Company;

                                      -18-
<PAGE>

the Company  shall give the Holder,  as promptly as possible but in any event at
least ten Trading Days prior to the applicable  date  hereinafter  specified,  a
notice  stating (x) the date on which a record is to be taken for the purpose of
such dividend,  distribution or rights or warrants, or, if a record is not to be
taken, the date as of which the holders of Common Stock of record to be entitled
to such dividend,  distribution or rights are to be determined,  or (y) the date
on  which  such   reclassification,   consolidation,   merger,   other  business
combination transaction, sale, transfer, dissolution,  liquidation or winding-up
is  expected  to  become  effective  or  occur,  and the  date as of which it is
expected  that  holders  of Common  Stock of record  who  shall be  entitled  to
exchange their Common Stock for securities or other  property  deliverable  upon
such  reclassification,   consolidation,   merger,  other  business  combination
transaction,  sale,  transfer,  dissolution,  liquidation or winding-up shall be
determined.  Such  notice  shall not  include  any  information  which  would be
material  non-public  information for purposes of the 1934 Act.  Failure to give
such notice, or any defect therein, shall not affect the legality or validity of
such dividend,  distribution,  reclassification,  consolidation,  merger,  sale,
transfer, dissolution, liquidation or winding-up. In the case of any such action
of which the Company gives such notice to the Holder or is required to give such
notice to the Holder,  the Holder shall be entitled to give a Conversion  Notice
which is contingent on the completion of such action.

                                   ARTICLE III

                                CERTAIN COVENANTS

         So long as at least $3,750,000 aggregate principal amount of this Note,
the Other Notes and the Warrant Notes are  outstanding or issuable upon exercise
of  unexercised  Warrants,  unless the  Company  shall have  obtained  the prior
written consent of the Majority Holders:

         3.1 Limitations on Certain  Indebtedness.  The Company will not itself,
and will not permit any Subsidiary to,  create,  assume,  incur or in any manner
become liable in respect of,  including,  without  limitation,  by reason of any
business  combination  transaction  (all of which  are  referred  to  herein  as
"incurring"), any Indebtedness other than Permitted Indebtedness.

         3.2 Maintenance of Net Cash, Cash Equivalent and Short-Term  Investment
Balances.  The Company shall maintain Net Cash,  Cash  Equivalent and Short-Term
Investment  Balances  at all times at least equal to the  aggregate  outstanding
principal  amount of this  Note,  the  Other  Notes and the  Warrant  Notes.  In
computing Net Cash,  Cash Equivalent and Short-Term  Investment  Balances of the
Company,  such computation shall be made on the basis of the Company's Net Cash,
Cash Equivalent and Short-Term  Investment  Balances  standing alone except that
there shall be included therein the amount,  if any, by which the Net Cash, Cash
Equivalent and Short-Term  Investment Balances of each Subsidiary on the date of
determination  under this Section 3.2 exceed the sum of (x) the  liabilities  of
the type required to be reflected on a balance sheet prepared in accordance with
Generally Accepted  Accounting  Principles of such Subsidiary proposed as of the
date of  determination  under  this  Section  3.2 plus (y)  liabilities  of such
Subsidiary  under  agreements,   contracts  or  other   instruments   (excluding
liabilities  of such  Subsidiary to the Company under a  cost-sharing  agreement
that  meets the  requirements  of  Section  3.11 to the  extent  payment of such
liabilities is not yet due) which  liabilities  are not required to be reflected
on such a  balance  sheet on such  date of  determination,  to the  extent  such
liabilities  exceed  $500,000.  Within 30 days  after  the end of each  calendar
quarter,  the Company shall furnish to the Holder a Company  Certificate setting
forth the amount of the  Company's  Net Cash,  Cash  Equivalent  and  Short-Term
Investment Balances and the outstanding principal amount of this Note, the Other
Notes and the  Warrant  Notes as of the end of such  calendar  quarter but which
shall  not  contain  any  information   which  

                                      -19-
<PAGE>

would  be  material,  non-public  information  concerning  the  Company  for the
purposes of the 1934 Act.

         3.3 Payment of  Obligations.  The Company will pay and  discharge,  and
will  cause  each  Significant  Subsidiary  to  pay  and  discharge,  all  their
respective material obligations and liabilities,  including, without limitation,
tax  liabilities,  except  where  the same  may be  contested  in good  faith by
appropriate proceedings.

         3.4 Maintenance of Property;  Insurance. (a) The Company will keep, and
will  cause  each  Significant  Subsidiary  to keep,  all  property  useful  and
necessary in its business in good working order and condition, ordinary wear and
tear excepted.

                  (b) The Company will maintain, and will cause each Significant
Subsidiary  to  maintain,  with  financially  sound  and  responsible  insurance
companies,   insurance,   including,  without  limitation,   products  liability
insurance,  in at least such  amounts  and against  such risks as is  reasonably
adequate for the conduct of their  respective  businesses and the value of their
respective properties.

         3.5 Conduct of Business and Maintenance of Existence.  The Company will
continue,  and will cause each Subsidiary to continue,  to engage in business of
the same  general  type as now  conducted  by the Company and the  Subsidiaries,
taken as a whole.  The Company will  preserve,  renew and keep in full force and
effect, and will cause each Significant  Subsidiary to preserve,  renew and keep
in full  force  and  effect  their  respective  corporate  existence  and  their
respective  rights,  privileges  and  franchises  necessary  or desirable in the
normal  conduct of business  except  where the failure to do so would not have a
material adverse effect on the Company and the  Subsidiaries,  taken as a whole,
or on the  ability of the  Company to perform  and comply  with its  obligations
under the Transaction Documents.

         3.6 Compliance with Laws. The Company will comply,  and will cause each
Significant  Subsidiary to comply,  in all material respects with all applicable
laws,  ordinances,  rules,  regulations,  decisions,  orders and requirements of
governmental   authorities   and   courts   (including,    without   limitation,
environmental  laws) except (i) where compliance  therewith is contested in good
faith by appropriate  proceedings or (ii) where  non-compliance  therewith could
not  reasonably be expected to have a material  adverse  effect on the business,
condition  (financial  or  otherwise),  operations,  performance,  properties or
prospects of the Company and the Subsidiaries, taken as a whole.

         3.7  Investment  Company  Act.  The  Company  will not be or  become an
open-end  investment  trust,  unit investment  trust or face-amount  certificate
company  that  is or is  required  to  be  registered  under  Section  8 of  the
Investment Company Act of 1940, as amended.

         3.8 Limitations on Asset Sales,  Liquidations,  Etc.;  Certain Matters.
The Company shall not:

                  (a) sell,  convey or otherwise dispose of all or substantially
all of the assets of the Company as an entirety or  substantially as an entirety
in a single transaction or in a series of related transactions; or

                  (b)  liquidate,  dissolve or otherwise  wind up the affairs of
the Company.

                                      -20-
<PAGE>

For  purposes  of the  preceding  clause (b), a  consolidation  or merger of the
Company in and of itself shall not be considered a  liquidation,  dissolution or
winding up of the Company.

         3.9  Limitations  on Liens.  The Company will not itself,  and will not
permit any Subsidiary to, create, assume or suffer to exist any mortgage,  lien,
pledge,  security  interest or other charge or encumbrance  (including,  without
limitation, the lien or retained security title of a conditional vendor), all of
which are referred to below as "liens",  upon all or any part of its property of
any character, whether owned at the date hereof or thereafter acquired, except:

                  (a) liens upon any property of any Subsidiary or  Subsidiaries
as security for indebtedness owing to the Company;

                  (b)  purchase  money liens upon any  property  acquired by the
Company or any  Subsidiary  after the Issuance  Date, or liens  existing on such
property at the time of acquisition  after the Issuance Date;  provided that (i)
no such lien shall  extend to or cover any other  property of the Company or any
Subsidiary,  (ii) the principal amount of indebtedness secured by each such lien
on any such property shall not exceed the cost (including such principal  amount
of the  indebtedness  secured  thereby) to the Company or the  Subsidiary of the
property  subject  thereto,  and (iii)  the  aggregate  principal  amount of all
indebtedness of the Company and all Subsidiaries  secured by all liens described
in this subsection (b) and any extensions,  renewals or replacements thereof, at
any one time outstanding, shall not exceed $7,500,000.00 for the Company and the
Subsidiaries;  and the extending, renewing or replacing of any lien permitted by
this subsection (b) or of the indebtedness secured thereby;  provided,  however,
that in any  such  case  the lien by which  any  lien is  extended,  renewed  or
replaced  shall not extend to or cover any other  property of the Company or any
Subsidiary and the principal amount of such  indebtedness  extended,  renewed or
replaced shall not be increased;

                  (c) liens  securing this Note, the Other Notes and the Warrant
Notes ratably;

                  (d) liens for taxes or assessments or governmental  charges or
levies on its property if such taxes or  assessments  or charges or levies shall
not at the time be due and payable or if the amount, applicability,  or validity
of any such tax, assessment, charge or levy shall currently be contested in good
faith by appropriate  proceedings or necessary preliminary steps are being taken
to  contest,  compromise  or settle  the  amount  thereof  or to  determine  the
applicability or validity thereof and if the Company or such Subsidiary,  as the
case may be,  shall  have set aside on its  books  reserves  (segregated  to the
extent required by sound accounting practice) deemed by it adequate with respect
thereto;  deposits  or  pledges  to secure  payment  of  worker's  compensation,
unemployment insurance,  old age pensions or other social security;  deposits or
pledges to secure performance of bids, tenders,  contracts (other than contracts
for the  payment  of money  borrowed  or  credit  extended),  leases,  public or
statutory obligations,  surety or appeal bonds, or other deposits or pledges for
purposes of like general nature in the ordinary course of business;  mechanics',
carriers',  workers',  repairmen's  or other like liens  arising in the ordinary
course of business securing obligations which are not overdue for a period of 60
days, or which are in good faith being  contested or  litigated,  or deposits to
obtain the  release  of such  liens;  liens  created  by or  resulting  from any
litigation or legal  proceedings or proceedings being contested in good faith by
appropriate proceedings,  provided any execution levied thereon shall be stayed;
leases  made,  or existing  on  property  acquired,  in the  ordinary  course of
business;  landlords'  liens under leases to which the Company or any Subsidiary
is a party; and zoning restrictions,  easements, licenses or restrictions on the
use of real property or minor irregularities in title thereto; provided that all
such liens described in this subsection (d) do not, in the aggregate, materially
impair the use of such property in the operations of the 

                                      -21-
<PAGE>

business of the Company or any  Subsidiary or the value of such property for the
purpose of such business; and

                  (e)  liens   existing  on  the  Issuance   Date  securing  the
obligations  and covering the property listed in Schedule 4(r) to the Securities
Purchase Agreement and which liens constitute liens only on equipment, fixtures,
furnishings, furniture, and leasehold improvements and related computer software
the acquisition of which was financed with the proceeds of such obligations.

         3.10 Listing Eligibility Reporting. The Company shall notify the Holder
from time to time within five days after the Company  first  learns that it does
not meet any of the  applicable  requirements  for the continued  listing of the
Common Stock on the principal  securities market or exchange on which the Common
Stock is listed from time to time.

         3.11 Transactions  with Affiliates.  The Company will not, and will not
permit any  Subsidiary,  directly or indirectly,  to pay any funds to or for the
account  of,  make  any   investment   (whether  by   acquisition  of  stock  or
Indebtedness,  by  loan,  advance,  transfer  of  property,  guarantee  or other
agreement to pay, purchase or service, directly or indirectly, any Indebtedness,
or otherwise)  in,  lease,  sell,  transfer or otherwise  dispose of any assets,
tangible or  intangible,  to, or  participate  in, or effect any  transaction in
connection  with,  any joint  enterprise or other joint  arrangement  with,  any
Affiliate of the Company,  except, on terms to the Company or such Subsidiary no
less  favorable  than  terms  that  could be  obtained  by the  Company  or such
Subsidiary from a Person that is not an Affiliate of the Company,  as determined
in  good  faith  by  the  Board  of  Directors;   provided,  however,  that  any
cost-sharing  arrangement between the Company and any Subsidiary which meets the
requirements for a qualified cost sharing  arrangement under Treasury Regulation
Section 1.482-7 shall be deemed to meet the requirements of this Section 3.11.

         3.12 Rule 144A Information Requirement.  Within the period prior to the
expiration  of the holding  period  applicable to sales hereof under Rule 144(k)
under the 1933 Act (or any successor  provision),  the Company shall, during any
period in which it is not subject to Section13 or 15(d) under the 1934 Act, make
available  to the Holder or any  holder of shares of Common  Stock  issued  upon
conversion hereof which continue to be Restricted  Securities in connection with
any sale thereof and any prospective purchaser of this Note from the Holder, the
information  required  pursuant to Rule  144A(d)(4)  under the 1933 Act upon the
request  of the Holder  and it will take such  further  action as the Holder may
reasonably  request,  all to the extent required from time to time to enable the
Holder to sell this Note  without  registration  under the 1933 Act  within  the
limitation of the  exemption  provided by Rule 144A, as Rule 144A may be amended
from time to time.  Upon the request of the Holder,  the Company will deliver to
the  Holder  a  written  statement  as to  whether  it has  complied  with  such
requirements.

                                   ARTICLE IV

                                EVENTS OF DEFAULT

         4.1 Events of Default. If any of the following events of default (each,
an "Event of Default") shall occur:

                  (a) Failure to Pay  Principal or Interest.  The Company  fails
         (1) to pay the principal, Optional Redemption Consideration, Repurchase
         Price or  Registration  Repurchase  Price  hereof when due,  whether at
         maturity,   upon  redemption,   upon

                                      -22-
<PAGE>

         acceleration or otherwise, as applicable, or (2) to pay any installment
         of interest hereon when due and, in the case of this clause (2) of this
         Section  4.1(a)  only,  such  failure  continues  for a period  of five
         Business Days after the due date thereof; or

                  (b) Conversion  and the Shares.  The Company fails to issue or
         cause to be issued  shares of Common Stock to the Holder upon  exercise
         by the Holder of the conversion or purchase rights of the Holder within
         two Trading  Days after the due date  therefor in  accordance  with the
         terms of this Note,  any Other Note, any Warrant Note, any Common Stock
         Warrant or any Other  Common  Stock  Warrant or fails to  transfer  any
         certificate  for  shares of Common  Stock  issued  to the  Holder  upon
         conversion  of this Note or in payment of  interest on this Note as and
         when required by this Note and the Securities Purchase Agreement; or

                  (c) Breach of  Covenant.  The Company (1) fails to comply with
         Section  3.1,  3.2,  3.8,  3.9,  or 3.10 or (2)  fails to comply in any
         material  respect with any provision of Article III of this Note (other
         than  Section  3.1,  3.2,  3.8,  3.9,  or 3.10) or  breaches  any other
         material  covenant or other  material  term or  condition  of this Note
         (other than as  specifically  provided in clauses (a), (b) or (c)(1) of
         this Section 4.1), the Securities Purchase Agreement,  the Warrants, or
         the Warrant  Notes,  and in the case of this clause (2) of this Section
         4.1(c)  only,  such  breach  continues  for a period  of 15 days  after
         written notice thereof to the Company from the Holder or within 30 days
         after  delivery  of such  notice  if,  and only  if,  such  default  is
         reasonably  capable of cure within 30 days after such notice and at all
         times during such 30-day period the Company has been diligently  taking
         action to cure such  default and such cure cannot be  completed  within
         such 15-day period; or

                  (d) Breach of  Representations  and  Warranties.  Any material
         representation  or  warranty  of  the  Company  made  herein  or in any
         agreement, statement or certificate given in writing pursuant hereto or
         in connection herewith (including,  without limitation,  the Securities
         Purchase  Agreement)  shall  be  false or  misleading  in any  material
         respect when made; or

                  (e)  Certain  Voluntary   Proceedings.   The  Company  or  any
         Significant  Subsidiary  shall  commence  a  voluntary  case  or  other
         proceeding  seeking  liquidation,  reorganization  or other relief with
         respect  to itself or its debts  under any  bankruptcy,  insolvency  or
         other similar law now or hereafter in effect or seeking the appointment
         of a trustee, receiver, liquidator, custodian or other similar official
         of it or any substantial part of its property,  or shall consent to any
         such relief or to the  appointment of or taking  possession by any such
         official in an involuntary case or other proceeding  commenced  against
         it, or shall make a general assignment for the benefit of creditors, or
         shall fail generally to pay its debts as they become due or shall admit
         in writing its inability generally to pay its debts as they become due;
         or

                  (f) Certain  Involuntary  Proceedings.  An involuntary case or
         other  proceeding  shall  be  commenced  against  the  Company  or  any
         Significant  Subsidiary  seeking  liquidation,  reorganization or other
         relief with respect to it or its debts under any bankruptcy, insolvency
         or  other  similar  law now or  hereafter  in  effect  or  seeking  the
         appointment  of a trustee,  receiver,  liquidator,  custodian  or other
         similar  official of it or any  substantial  part of its property,  and
         such involuntary case or other proceeding shall remain  undismissed and
         unstayed for a period of sixty consecutive days; or

                                      -23-
<PAGE>

                  (g) Judgments. Any court of competent jurisdiction shall enter
         one or more final  judgments  against the Company or any  Subsidiary or
         any of their  respective  properties  or other  assets in an  aggregate
         amount in excess of  $750,000,  which is not vacated,  bonded,  stayed,
         discharged,  satisfied  or waived  for a period  of thirty  consecutive
         days; or

                  (h) Default under Other  Agreements and  Instruments.  (1) The
         Company or any Subsidiary shall (i) default in any payment with respect
         to any  indebtedness  for  borrowed  money (other than this Note) which
         indebtedness   has  an  outstanding   principal  amount  in  excess  of
         $1,000,000  individually or $2,500,000 in the aggregate for the Company
         and its  Subsidiaries,  beyond the period of grace, if any, provided in
         the instrument or agreement under which such  indebtedness  was created
         or (ii) default in the  observance  or  performance  of any  agreement,
         covenant or condition relating to any such indebtedness or contained in
         any instrument or agreement  evidencing,  securing or relating thereto,
         or any other event shall occur or condition  exist, the effect of which
         default  or other  event or  condition  is to cause,  or to permit  the
         holder or holders of such indebtedness (or a trustee or agent on behalf
         of such holder or holders) to cause,  any such  indebtedness  to become
         due  prior to its  stated  maturity  and such  default  or event  shall
         continue beyond the period of grace, if any, provided in the instrument
         or agreement  under which such  indebtedness  was created (after giving
         effect  to  any  consent  or  waiver   obtained   and  then  in  effect
         thereunder);   provided,   however,  that  the  events  and  conditions
         described in the preceding clauses (i) and (ii) shall not constitute an
         Event of Default  unless and until the Company fails to take the action
         necessary to correct such event or condition  within five Business Days
         of becoming aware of such event or condition;  (2) any  indebtedness of
         the  Company  or any  of  its  Subsidiaries  which  has an  outstanding
         principal amount in excess of $1,500,000  individually or $3,500,000 in
         the aggregate  shall,  in accordance  with its terms, be declared to be
         due and  payable,  or required to be prepaid  other than by a regularly
         scheduled or required payment prior to the stated maturity thereof; or

                  (i) Delisting of Common Stock. The Common Stock shall cease to
         be  listed  on any of  Nasdaq,  the NYSE or the AMEX and  shall  remain
         unlisted for a period of three days;

then,  (X) upon the  occurrence  and  during  the  continuation  of any Event of
Default specified in clause (a), (b), (c), (d), (g), (h), or (i) of this Section
4.1 at the option of the Holder the Company  shall,  and upon the  occurrence of
any Event of Default  specified  in clause (e) or (f) of this  Section  4.1, the
Company  shall,  pay to the  Holder  an  amount  equal  to  the  sum of (A)  the
outstanding  principal  amount of this Note plus (B) accrued and unpaid interest
on such  principal  amount to the date of payment  plus (C)  accrued  and unpaid
Default Interest, if any, on the amount referred to in the immediately preceding
clause (B) at the rate provided in this Note to the date of payment, and (Y) all
other amounts payable  hereunder shall immediately  become due and payable,  all
without demand, presentment or notice, all of which hereby are expressly waived,
together with all costs,  including,  without limitation,  reasonable legal fees
and expenses,  of  collection,  and (Z) the Holder shall be entitled to exercise
all other rights and remedies available at law or in equity.

                                    ARTICLE V

                      REPURCHASE UPON A REPURCHASE EVENT OR
                          REGISTRATION REPURCHASE EVENT


                                      -24-
<PAGE>

         5.1 Repurchase Right upon Repurchase Event. If a Repurchase Event shall
occur,  then,  in addition to any other  rights of the Holder,  the Holder shall
have the right, at the Holder's option, to require the Company to repurchase all
of this Note, or any portion hereof (in a minimum  principal  amount of $100,000
or integral  multiples thereof (or such lesser remaining  outstanding  principal
amount of this Note)),  on the repurchase  date that is five Business Days after
the date of the Holder Notice  delivered with respect to such Repurchase  Event.
The Holder shall have the right to require the Company to repurchase  all or any
such  portion of this Note if a  Repurchase  Event  occurs at any time while any
portion of the principal  amount of this Note is outstanding at a price equal to
the  Repurchase  Price;  provided,  however,  that  if  such  right  to  require
repurchase  of this Note arises in  connection  with a  transaction  that (i) is
intended to qualify as a pooling of interests  under the Pooling  Standards  and
(ii) but for the exercise of  repurchase  rights under  Section 5.1 of this Note
and  Section  5.1 of the Other  Notes and the  Warrant  Notes,  may qualify as a
pooling of interests under the Pooling  Standards,  then,  without relieving the
Company of its other  obligations  under  this Note,  the  Company  may,  in the
reasonable  exercise of its  discretion,  elect not to  repurchase  such Note in
order to comply with the Pooling Standards.

         5.2 Notices;  Method of Exercising  Repurchase  Rights,  Etc. (a) On or
before the fifth  Business Day after the occurrence of a Repurchase  Event,  the
Company  shall  give to the  Holder a Company  Notice of the  occurrence  of the
Repurchase  Event and of the  repurchase  right set forth  herein  arising  as a
result thereof. Such Company Notice shall set forth:

                  (i) the date by which the repurchase  right must be exercised,
and

                  (ii) a description of the procedure (set forth in this Section
5.2) which the Holder must follow to exercise the repurchase right.

No failure of the Company to give a Company Notice or defect therein shall limit
the Holder's  right to exercise the  repurchase  right or affect the validity of
the proceedings for the repurchase of this Note or portion hereof.

                  (b) To exercise the repurchase right, the Holder shall deliver
to the  Company on or before the 30th day after a Company  Notice (or if no such
Company  Notice has been given,  within 40 days after the Holder first learns of
the  Repurchase  Event) a Holder Notice setting forth the name of the Holder and
the  principal  amount of this Note to be  repurchased.  A Holder  Notice may be
revoked  by the  Holder  at any time  prior to the  time  the  Company  pays the
applicable Repurchase Price to the Holder.

                  (c) If the Holder  shall have given a Holder  Notice,  then on
the repurchase date that is five Business Days after the date such Holder Notice
is given (or such later date as the Holder  surrenders  this Note duly  endorsed
for transfer) the Company shall repurchase this Note or the portion of this Note
as stated in such Holder Notice by making payment in immediately available funds
of the applicable Repurchase Price to such account as specified by the Holder by
notice given to the Company at least one  Business  Day prior to the  applicable
repurchase date.

         5.3  Repurchase  Right upon  Registration  Repurchase  Event.  (1) If a
Registration  Repurchase Event occurs,  then, in addition to any other rights of
the Holder,  the Holder shall have the right, at the Holder's option, to require
the Company to repurchase in accordance  with this Section 5.3 all of this Note,
or from  time to time any  portion  hereof  (in a

                                      -25-
<PAGE>

minimum  principal  amount of $100,000 or  integral  multiples  thereof (or such
lesser remaining principal amount of this Note), at the applicable  Registration
Repurchase Price.

                  (2) To exercise the repurchase  right pursuant to this Section
5.3, the Holder shall give a Holder  Registration  Repurchase Notice as follows:
(i) if the  Registration  Repurchase  Event  occurs by  reason of the  Company's
failure to timely  file the  Registration  Statement  with the SEC,  at any time
prior to the  earlier  of (x) the date which is 30 days after such event and (y)
the date the Company files the  Registration  Statement  with the SEC or (ii) if
the Registration  Repurchase Event occurs by reason of the non-occurrence of the
SEC  Effective  Date within 90 days or 135 days,  as the case may be,  after the
Issuance  Date,  at  any  time  prior  to  the  SEC  Effective  Date.  A  Holder
Registration Repurchase Notice may be revoked by the Holder at any time prior to
the time the Company pays the applicable Registration Repurchase Price.

                  (3) If the  Holder  shall  have  given a  Holder  Registration
Repurchase Notice,  then on the repurchase date that is five Business Days after
the date such Holder Registration Repurchase Notice is given (or such later date
as the Holder  surrenders  this Note to the Company duly  endorsed for transfer)
the Company shall  repurchase this Note or the portion of this Note as stated in
such Holder  Registration  Repurchase  Notice by making  payment in  immediately
funds on such repurchase date of the applicable Registration Repurchase Price to
such  account as specified by the Holder by notice given to the Company at least
one Business Day prior to the applicable repurchase date.

         5.4 Other.  (a) If the Company fails to  repurchase  on the  applicable
repurchase date this Note (or portion  hereof) as to which the repurchase  right
has been  properly  exercised  pursuant to this  Article V, then the  Repurchase
Price or the Registration  Repurchase Price, as the case may be, for the portion
(which,  if applicable,  may be all) of this Note which is required to have been
so  repurchased  shall bear interest to the extent not  prohibited by applicable
law from the applicable repurchase date until paid at the Default Rate.

                  (b) If a  portion  of  this  Note is to be  repurchased,  upon
surrender  of this  Note to the  Company  in  accordance  with the terms of this
Article V, the Company shall execute and deliver to the Holder  without  service
charge,  a new  Note or  Notes,  having  the same  date  hereof  and  containing
identical  terms  and  conditions,  in such  denomination  or  denominations  as
requested by the Holder in aggregate  principal amount equal to, and in exchange
for,  the  unrepurchased  portion  of  the  principal  amount  of  the  Note  so
surrendered.

                  (c) The  Company  shall  notify the Holder of any claim by the
Company of manifest error in a Holder Notice or a Holder Registration Repurchase
Notice within three Business Days after the Holder gives such notice and no such
claim of error shall limit or delay  performance of the Company's  obligation to
repurchase such portion of the Note which is not in dispute and (ii) such notice
shall be  deemed  for all  purposes  to be in proper  form  unless  the  Company
notifies  the Holder  within one  Business  Day after such notice has been given
(which notice from the Company shall specify all defects in such notice) and any
Holder  Notice or Holder  Registration  Repurchase  Notice  containing  any such
defect shall  nonetheless be effective on the date given if the Holder  promptly
undertakes in writing to correct all such defects.

                                   ARTICLE VI

                SATISFACTION AND DISCHARGE OF CERTAIN PROVISIONS


                                      -26-
<PAGE>

         6.1      Discharge of Certain Provisions.  (a) If

                  (i) the  Company  and the  Trustee  shall  have  executed  and
         delivered one to the other the Trust Agreement,  which Trustee shall be
         approved  and  which  Trust  Agreement  shall  be in  form,  scope  and
         substance  as shall have been  approved by the Majority  Holders,  such
         approval to be evidenced by the written approval of the Trustee and the
         Trust Agreement  given by the Majority  Holders prior to such execution
         and delivery;

                  (ii) the Company  shall have  deposited  with the Trustee,  in
         trust, funds or Government  Obligations,  the principal of and interest
         on which when due will,  together  with any funds set aside at the same
         time and without the necessity for investment or  reinvestment  of such
         funds or for further investment or reinvestment of the principal amount
         of or interest on such Government Obligations, provide funds sufficient
         to pay at maturity or upon redemption all of this Note, the Other Notes
         and the Warrant  Notes,  including  principal  and  interest  due or to
         become due to the Maturity Date or the maturity  date  thereof,  as the
         case may be, or earlier redemption;

                  (iii) if such  deposit  is being made in  connection  with the
         redemption of this Note, the Other Notes and the Warrant Notes pursuant
         to Section 1.2 and the comparable provisions of the Other Notes and the
         Warrant Notes prior to their maturity, all action other than the giving
         of notices of redemption necessary to redeem this Note, the Other Notes
         and the Warrant Notes as of the specified  redemption date or dates for
         this Note,  the Other Notes and the Warrant Notes shall have been taken
         and arrangements  reasonably satisfactory to the Majority Holders shall
         have been made for the giving of notices of such redemption; and

                  (iv)  notice of such  deposit  shall  have  been  given to the
         Holder and the holders of the Other Notes and the Warrant Notes, within
         ten days after the date of such deposit;

and the  Company  shall  also pay or cause to be paid  all  other  sums  payable
hereunder  by the  Company,  then on the date which is 92 days after the date of
such  deposit by the  Company  with the  Trustee,  so long as during such 92-day
period no Event of Default  specified  in clause  (e) or (f) of  Section  4.1 or
event which with notice or passage of time,  or both,  would  become an Event of
Default specified in clause (e) or (f) of Section 4.1 has occurred (x) this Note
shall  cease to be of further  effect  (except as  provided  herein) and (y) the
Holder,  on demand of the Company  accompanied by a Company  Certificate  and an
opinion of counsel and at the cost and  expense of the  Company,  shall  execute
proper instruments  acknowledging the satisfaction and discharge of this Note to
the extent set forth herein.

                  (b) So long as this Note shall remain  outstanding  after such
discharge,  this Note shall continue in effect following the discharge  provided
for above  solely  with  respect  to (1)  rights of  registration  of  transfer,
exchange  or  replacement  of this Note,  (2)  rights to receive  payment of the
principal and Optional  Redemption  Consideration  hereof and interest hereon in
accordance with the terms of this Note from such deposited funds or the proceeds
of or interest on such deposited  Government  Obligations,  (3) the rights under
Article  II, and (4) the  rights  under  Sections  3.5,  3.6 and 3.7;  provided,
however,  that,  following such discharge,  no claim for payment of principal or
the Optional Redemption  Consideration of or interest on this Note shall be made
against the Company.  Upon such  discharge,  any Event of Default which occurred
prior to such discharge  solely by reason of one or more provisions of this Note
with which the 

                                      -27-
<PAGE>

Company thereafter is no longer obligated to comply,  then such Event of Default
shall no longer exist.

         6.2  Deposited  Moneys  and  Government   Obligations  to  Be  Held  in
Accordance with Trust Agreement.  All funds and Government Obligations deposited
with the  Trustee  pursuant to Section 6.1 shall be held in trust and subject to
and in  accordance  with the terms of the  Trust  Agreement  and such  funds and
interest on such Government  Obligations  shall be applied by the Trustee to the
payment of this Note,  the Other Notes and the Warrant Notes in accordance  with
their terms and the Trust Agreement.

         6.3  Reinstatement.  If (i) the Trustee is unable to apply any funds in
accordance  with  Section 6.2 and the Trust  Agreement by reason of any order or
judgment  of any  court or  governmental  authority  enjoining,  restraining  or
otherwise  prohibiting such application and (ii) the Majority Holders so specify
by notice to the Company,  the Company's  obligations under this Note, the Other
Notes and the Warrant Notes shall be revived and reinstated as though no deposit
had occurred pursuant to Section 6.1 until such time as the Trustee is permitted
to apply all such funds in accordance with Section 6.2 and the Trust Agreement.

                                   ARTICLE VII

                                   DEFINITIONS

         7.1 Certain Defined Terms. (a) All the agreements or instruments herein
defined shall mean such  agreements or  instruments as the same may from time to
time be  supplemented  or amended or the terms thereof waived or modified to the
extent permitted by, and in accordance with, the terms thereof and of this Note.

                  (b) The  following  terms  shall have the  following  meanings
(such meanings to be equally applicable to both the singular and plural forms of
the terms defined):

                  "Affiliate"  means,  with  respect  to any  Person,  any other
Person  that  directly,  or  indirectly  through  one  or  more  intermediaries,
controls,  is controlled by or under common control with the subject Person. For
purposes  of the term  "Affiliate",  the term  "control"  (including  the  terms
"controlling",  "controlled  by" and  "under  common  control  with")  means the
possession, direct or indirect, of the power to direct or to cause the direction
of the  management  and policies of a Person,  whether  through the ownership of
securities, by contract or otherwise.

                  "AMEX" means the American Stock Exchange, Inc.

                  "Applicable Rate" means 12 percent (12%) per annum.

                  "Board  of  Directors"  means the  Board of  Directors  of the
Company.

                  "Board  Resolution" means a copy of a resolution  certified by
the Secretary or an Assistant Secretary of the Company to have been duly adopted
by the Board of Directors,  or duly authorized  committee thereof (to the extent
permitted by applicable  law), and to be in full force and effect on the date of
such certification, and delivered to the Holder.

                  "Business  Day"  shall  mean any day  other  than a  Saturday,
Sunday or a day on which commercial banks in The City of New York are authorized
or required by law or executive order to remain closed.

                                      -28-
<PAGE>

                  "Cash, Cash Equivalent and Short-Term  Investment Balances" of
any Person at any date shall be determined  from such Person's books  maintained
in accordance with Generally  Accepted  Accounting  Principles,  and shall mean,
without duplication,  the sum of (1) the cash owned by such Person on such date,
(2) all assets which would on a balance sheet of such Person prepared as of such
date in accordance with Generally Accepted  Accounting  Principles be classified
as cash or cash equivalents and (3) all assets which would on a balance sheet of
such  Person  prepared as of such date in  accordance  with  Generally  Accepted
Accounting Principles be classified as short-term investments.

                  "Common Stock" includes the Company's  Common Stock, par value
$.01 per share, and the related Preferred Share Purchase Rights (and any similar
rights  issued  with  respect to the  Common  Stock) as  authorized  on the date
hereof, and any other securities into which or for which the Common Stock or the
related  Preferred  Share  Purchase  Rights (and any similar  rights issued with
respect to the Common Stock) may be converted or exchanged pursuant to a plan of
recapitalization,  reorganization,  merger,  sale of assets or otherwise and any
stock (other than Common Stock) and other securities of the Company or any other
Person which the Holder at any time shall be entitled to receive,  or shall have
received,  on the  exercise  of this Note,  in lieu of or in  addition to Common
Stock.

                  "Common   Stock   Equivalent"   means  any  warrant,   option,
subscription  or  purchase  right with  respect to shares of Common  Stock,  any
security  convertible into,  exchangeable for, or otherwise entitling the holder
thereof to acquire, shares of Common Stock or any warrant, option,  subscription
or purchase right with respect to any such  convertible,  exchangeable  or other
security.

                  "Common  Stock  Warrants"  means  the  Common  Stock  Purchase
Warrants  issuable  or issued by the  Company  in the form of  Exhibit C to this
Note.

                  "Company"  shall  have  the  meaning  provided  in  the  first
paragraph of this Note.

                  "Company  Certificate"  means  a  certificate  of the  Company
signed by an Officer.

                  "Company Notice" means a Company Notice in the form of Exhibit
D to this Note.

                  "Conversion  Date" means the date on which a Conversion Notice
is given in accordance with Section 2.2(a).

                  "Conversion Notice" means a duly executed Notice of Conversion
of 12% Senior  Convertible Note due 2002  substantially in the form of Exhibit A
to this Note.

                  "Conversion  Price" means  $20.50,  subject to  adjustment  as
provided in Section 2.3.

                  "Current  Fair  Market  Value"  when used with  respect to the
Common  Stock as of a specified  date means with respect to each share of Common
Stock  the  average  of the  closing  prices  of the  Common  Stock  sold on all
securities  exchanges  (including  the  Nasdaq  National  Market  and the Nasdaq
SmallCap  Market)  on which the Common  Stock may at the time be listed,  or, if
there have been no sales on any such  exchange  on such day,  the average of the
highest bid and lowest  asked  prices on all such  exchanges  at the end of such
day,  or, if on such day the Common  Stock is not so listed,  the average of the
representative bid and asked prices 

                                      -29-
<PAGE>

quoted in the NASDAQ System as of 4:00 p.m.,  New York City time, or, if on such
day the  Common  Stock is not quoted in the NASDAQ  System,  the  average of the
highest bid and lowest asked price on such day in the domestic  over-the-counter
market as  reported  by the  National  Quotation  Bureau,  Incorporated,  or any
similar successor organization, in each such case averaged over a period of five
Trading Days  consisting of the day as of which the Current Fair Market Value of
Common  Stock is being  determined  (or if such day is not a  Trading  Day,  the
Trading Day next preceding such day) and the four consecutive Trading Days prior
to such  day.  If on the date  for  which  Current  Fair  Market  Value is to be
determined the Common Stock is not listed on any  securities  exchange or quoted
in the NASDAQ  System or the  over-the-counter  market,  the Current Fair Market
Value of Common Stock shall be the greater of (i) the highest price per share of
Common  Stock at which the  Company  has sold  shares of Common  Stock or Common
Stock  Equivalents  during the 365 days prior to the date of such  determination
and (ii) the highest  price per share which the Company could then obtain from a
willing  buyer  (not an  employee  or  director  of the  Company  at the time of
determination)  for shares of Common Stock sold by the Company,  from authorized
but unissued shares, as determined in good faith by the Board of Directors.

                  "Current  Market Price" shall mean the  arithmetic  average of
the  daily  Market  Prices  per share of  Common  Stock for the ten  consecutive
Trading Days immediately prior to the date in question;  provided, however, that
(1) if the "ex" date (as  hereinafter  defined)  for any event  (other  than the
issuance or distribution requiring such computation) that requires an adjustment
to the Conversion Price pursuant to Section 2.3(a),  (b), (c), (d), (e), (f), or
(g), occurs during such ten consecutive  Trading Days, the Market Price for each
Trading  Day prior to the "ex" date for such other  event  shall be  adjusted by
multiplying such Market Price by the same fraction by which the Conversion Price
is so required to be adjusted as a result of such other  event,  (2) if the "ex"
date for any event  (other than the  issuance  or  distribution  requiring  such
computation)  that requires an adjustment to the  Conversion  Price  pursuant to
Section  2.3(a),  (b), (c),  (d), (e), (f), or (g),  occurs on or after the "ex"
date for the issuance or  distribution  requiring such  computation and prior to
the day in question, the Market Price for each Trading Day on and after the "ex"
date for such other event shall be adjusted by multiplying  such Market Price by
the reciprocal of the fraction by which the  Conversion  Price is so required to
be  adjusted as a result of such other  event,  and (3) if the "ex" date for the
issuance  or  distribution  requiring  such  computation  is prior to the day in
question,  after taking into account any adjustment  required pursuant to clause
(1) or (2) of this  proviso,  the Market  Price for each Trading Day on or after
such "ex" date shall be  adjusted  by adding  thereto the amount of any cash and
the fair  market  value (as  determined  by the Board of  Directors  in a manner
consistent with any  determination  of such value for purposes of Section 2.3(d)
or (f),  whose  determination  shall  be  conclusive  and  described  in a Board
Resolution) of the evidences of indebtedness,  shares of capital stock or assets
being  distributed  applicable  to one share of Common  Stock as of the close of
business on the day before such "ex" date. For purposes of any computation under
Section  2.3(f),  the Current Market Price of the Common Stock on any date shall
be deemed to be the  arithmetic  average of the daily Market Prices per share of
Common Stock for such day and the next two  succeeding  Trading Days;  provided,
however,  that if the "ex"  date for any  event  (other  than the  Tender  Offer
requiring such  computation) that requires an adjustment to the Conversion Price
pursuant to Section 2.3(a),  (b), (c), (d), (e), (f), or (g), occurs on or after
the Expiration Time for the Tender Offer requiring such computation and prior to
the day in question, the Market Price for each Trading Day on and after the "ex"
date for such other event shall be adjusted by multiplying  such Market Price by
the reciprocal of the fraction by which the  Conversion  Price is so required to
be adjusted as a result of such other event. For purposes of this paragraph, the
term "ex" date,  (1) when used with  respect to any  issuance  or  distribution,
means the first date on which the  Common  Stock  trades,  regular  way,  on the
relevant  exchange

                                      -30-
<PAGE>

or in the relevant  market from which the Market Price was obtained  without the
right to receive such  issuance or  distribution,  (2) when used with respect to
any  subdivision or combination of shares of Common Stock,  means the first date
on which the Common  Stock  trades,  regular  way,  on such  exchange or in such
market  after  the  time  at  which  such  subdivision  or  combination  becomes
effective,  and (3) when used with  respect to any Tender  Offer means the first
date on which the Common Stock trades,  regular way, on such exchange or in such
market  after the  Expiration  Time of such Tender  Offer.  Notwithstanding  the
foregoing,  whenever  successive  adjustments to the Conversion Price are called
for  pursuant  to Section  2.3,  such  adjustments  shall be made to the Current
Market Price as may be  necessary or  appropriate  to  effectuate  the intent of
Section 2.3 and to avoid unjust or  inequitable  results as  determined  in good
faith by the Board of Directors.

                  "Default  Interest"  shall have the  meaning  provided  in the
first paragraph of this Note.

                  "Default Rate" means 20 percent per annum (or such lesser rate
equal to the highest rate permitted by applicable law).

                  "Depositary" means The Depository Trust Company.

                  "Eligible  Bank"  means a  corporation  organized  or existing
under the laws of the United States or any state,  having  combined  capital and
surplus of at least $100 million and subject to  supervision by federal or state
authority and which has a branch located in New York, New York or San Francisco,
California.

                  "Expiration  Time" shall have the meaning  provided in Section
2.3(f).

                  "Event of Default" shall have the meaning  provided in Article
IV.

                  "Fundamental Change" means

                  (a)  Any  consolidation  or  merger  of  the  Company  or  any
Subsidiary with or into another entity (other than a merger or  consolidation of
a  Subsidiary  into  the  Company  or  a  wholly-owned   Subsidiary)  where  the
stockholders  of the  Company  immediately  prior  to  such  transaction  do not
collectively  own at  least  51% of the  outstanding  voting  securities  of the
surviving corporation of such consolidation or merger immediately following such
transaction;  or the  sale  of all or  substantially  all of the  assets  of the
Company  and the  Subsidiaries  in a single  transaction  or a series of related
transactions; or

                  (b) The  occurrence of any  transaction or event in connection
with which all or  substantially  all the Common Stock shall be  exchanged  for,
converted  into,  acquired for or constitute the right to receive  consideration
(whether   by  means  of  an  exchange   offer,   liquidation,   tender   offer,
consolidation,  merger,  combination,   reclassification,   recapitalization  or
otherwise) which is not all or substantially all common stock which is (or will,
upon  consummation of or immediately  following such transaction or event,  will
be) listed on a national securities exchange or approved for quotation on Nasdaq
or any similar  United States system of automated  dissemination  of transaction
reporting of securities prices; or

                  (c) The  acquisition by a Person or entity or group of Persons
or entities acting in concert as a partnership,  limited partnership,  syndicate
or group,  as a result of a tender or exchange  offer,  open  market  purchases,
privately  negotiated  purchases  or  otherwise,   of

                                      -31-
<PAGE>

beneficial  ownership of securities of the Company  representing  50% or more of
the combined  voting power of the outstanding  voting  securities of the Company
ordinarily (and apart from rights accruing in special  circumstances) having the
right to vote in the election of directors.

                  "Generally  Accepted  Accounting  Principles"  for any  Person
means the generally accepted accounting principles and practices applied by such
Person from time to time in the preparation of its audited financial statements.

                  "Government  Obligations"  means  direct  obligations  of,  or
obligations the timely payment of the principal of and the interest on which are
unconditionally  guaranteed  by, the United States of America and which are not,
by their terms, callable.

                  "Holder"  shall  have  the  meaning   provided  in  the  first
paragraph of this Note.

                  "Holder Notice" means a Holder Notice in the form of Exhibit E
to this Note.

                  "Holder   Registration   Repurchase  Notice"  means  a  Holder
Registration Repurchase Notice in the form of as Exhibit F to this Note.

                  "Indebtedness"  as used in  reference  to any Person means all
indebtedness of such person for borrowed money,  the deferred  purchase price of
property,  goods and services and obligations under leases which are required to
be capitalized in accordance with Generally Accepted  Accounting  Principles and
shall include all such  indebtedness  guaranteed in any manner by such person or
in effect  guaranteed by such person through a contingent  agreement to purchase
and all  indebtedness  for the  payment or  purchase  of which  such  person has
contingently  agreed to advance or supply funds and all indebtedness  secured by
mortgage or other lien upon property owned by such person,  although such person
has not assumed or become liable for the payment of such indebtedness,  and, for
all purposes hereof,  such  indebtedness  shall be treated as though it has been
assumed by such person.

                  "Interest  Payment  Dates" shall mean each January 1, April 1,
July 1 and October 1 and the Maturity Date.

                  "Interest  Share  Price"  means,  with respect to any Interest
Payment  Date,  an amount equal to 95 percent of the  arithmetic  average of the
Market  Price  of one  share of  Common  Stock  for each of the ten  consecutive
Trading Days ending on and including the Trading Day immediately  preceding such
Interest Payment Date.

                  "Interest  Shares"  means the  shares of Common  Stock and the
related  Preferred Share Purchase Rights issuable in payment of interest on this
Note in accordance with Section 1.1.

                  "Interest  Shares  Measurement  Period" means with respect any
Interest  Payment Date the period of 15 consecutive  Trading Days  commencing on
and including the Trading Day immediately following such Interest Payment Date.

                  "Issuance  Date"  means the date  this Note was  issued to the
original Holder of this Note.

                  "Issuing Agent" means BankBoston,  N.A., its successor or such
other person who shall be serving as transfer agent and registrar for the Common
Stock and who shall have

                                      -32-
<PAGE>

been  authorized  by the  Company  to act as  conversion  agent for this Note in
accordance  with  the  Issuing  Agent  Instruction  and the  name,  address  and
telephone  number of whom shall have been given to the Holder by notice from the
Company.

                  "Issuing   Agent   Instruction"   means  the   Issuing   Agent
Instruction, dated March 24, 1999, from the Company to the Issuing Agent for the
benefit of the holders  from time to time of this Note,  the Other Notes and the
Warrant Notes.

                  "Majority Holders" means at any time the holders of this Note,
the Other  Notes and the  Warrant  Notes who hold this Note and Other  Notes and
Warrant  Notes  which,  based on the  outstanding  principal  amount  hereof and
thereof,  represent a majority of the aggregate  outstanding principal amount of
this Note, the Other Notes and the Warrant Notes.

                  "Market  Price" with  respect to any security on any day shall
mean the  closing  bid price of such  security  on such day on the Nasdaq or the
NYSE or the AMEX, as applicable,  or, if such security is not listed or admitted
to  trading  on the  Nasdaq,  the NYSE or the AMEX,  on the  principal  national
securities  exchange  or  quotation  system on which such  security is quoted or
listed or admitted to trading,  in any such case as reported by Bloomberg,  L.P.
or, if not quoted or listed or  admitted to trading on any  national  securities
exchange or quotation system, the average of the closing bid and asked prices of
such security on the over-the-counter market on the day in question, as reported
by the National Quotation Bureau  Incorporated,  or a similar generally accepted
reporting  service,  or if not so available,  in such manner as furnished by any
New York Stock  Exchange  member firm selected from time to time by the Board of
Directors for that purpose,  or a price determined in good faith by the Board of
Directors,  whose  determination  shall be  conclusive  and described in a Board
Resolution.

                  "Maturity Date" means March 24, 2002.

                  "Nasdaq" means the Nasdaq National Market.

                  "Net Cash, Cash Equivalent and Short-Term Investment Balances"
means  for any  Person at any time  such  Person's  Cash,  Cash  Equivalent  and
Short-Term Investment Balances less the sum of (1) the amount of any outstanding
Indebtedness of such Person's which is secured in whole or in part by Cash, Cash
Equivalent and Short-Term  Investment Balances plus (2) the maximum amount which
is not  outstanding and which may be borrowed  pursuant to any revolving  credit
facility or any  commitment to lend of or to such Person's  which at the time it
becomes outstanding will be secured in whole or in part by Cash, Cash Equivalent
and Short-Term Investment Balances.

                  "Newly  Issued  Shares"  shall have the  meaning  provided  in
Section 2.3(g).

                  "1934  Act"  means the  Securities  Exchange  Act of 1934,  as
amended.

                  "1933 Act" means the Securities Act of 1933, as amended.

                  "Note" means this  instrument  as originally  executed,  or if
later amended or supplemented, then as so amended or supplemented.

                  "NYSE" shall mean the New York Stock Exchange, Inc.

                                      -33-
<PAGE>

                  "Officer" means the Chairman of the Board, the Chief Executive
Officer, the President or the Chief Financial Officer of the Company.

                  "Optional Redemption Consideration" means (1)an amount in cash
equal to the sum of (A) the product  obtained by  multiplying  (i) the principal
amount of this Note that is  outstanding on the Optional  Redemption  Date times
(ii) the applicable Optional  Redemption  Percentage on such Optional Redemption
Date plus (B)  accrued  and  unpaid  interest  on such  principal  amount to the
Optional  Redemption Date plus (C) accrued and unpaid Default Interest,  if any,
on the amount  referred to in the immediately  preceding  clause (B) at the rate
provided in this Note to the  Optional  Redemption  Date and (2) a Common  Stock
Warrant that  initially (I) entitles the holder  thereof to purchase a number of
shares of Common  Stock  equal to the  quotient  obtained  by  dividing  (x) the
principal  amount of this Note  outstanding  immediately  prior to redemption of
this Note on the Optional  Redemption Date by (y)the  Conversion Price in effect
immediately prior to redemption of this Note on the Optional Redemption Date and
(II) has a Purchase  Price (as defined in the Common  Stock  Purchase  Warrants)
equal to the Conversion Price in effect  immediately prior to redemption of this
Note on the Optional  Redemption Date,  subject to adjustment as provided in the
Common Stock Warrants.

                  "Optional  Redemption  Date" means the  Business  Day on which
this Note is to be redeemed, but in no event later than the Maturity Date.

                  "Optional  Redemption  Notice"  means the Optional  Redemption
Notice in the form of Exhibit B to this Note.
<TABLE>
                  "Optional  Redemption  Percentage"  means with  respect to any
Optional  Redemption  Date during any period set forth below the  percentage set
forth below opposite such period:
<CAPTION>
                                                                                               Optional
                                                                                              Redemption
         Date                                                                                 Percentage
         ----                                                                                 ----------
<S>                                                                                               <C> 
         Issuance Date to date that is 365 days after Issuance Date                               110%

         From and after date that is 366 days after Issuance Date to Maturity Date                105%
</TABLE>

                  "Other Common Stock Warrants" means the Company's Common Stock
Purchase  Warrants  issuable  or  issued  pursuant  to the  Other  Notes and the
Warrants.

                  "Other Notes" means the several 12% Senior  Convertible  Notes
due 2002  issued  by the  Company  pursuant  to the  Other  Securities  Purchase
Agreements.

                  "Other Securities Purchase Agreements" means the several Other
Securities  Purchase  and  Exchange  Agreements,  dated  as of the  date  of the
Securities Purchase Agreement, by and between the Company and the several buyers
named therein.

                  "Permitted Indebtedness" means

                                      -34-
<PAGE>

                           (1)   Indebtedness   not  in  excess  of  $13,100,000
aggregate  principal amount which is either (x) outstanding on the Issuance Date
and which would be reflected on a  consolidated  balance sheet of the Company as
of the Issuance Date prepared in accordance with Generally  Accepted  Accounting
Principles  or (y)  Indebtedness  incurred  after the Issuance  Date pursuant to
commitments  available  to the Company or any  Subsidiary  under a lease line in
effect  on the  date  of  execution  and  delivery  of the  Securities  Purchase
Agreement;

                           (2) Indebtedness  incurred by SUGEN Europe A.G. after
the Issuance Date in the aggregate principal amount not in excess of $25,000,000
(or the foreign currency  equivalent  thereof based on the foreign exchange rate
in  effect on the date of  incurrence  of such  Indebtedness)  and for which the
Company  shall have no liability or  obligation  for payment of any amount which
may become due in respect of such Indebtedness;

                           (3) Indebtedness  incurred after the Issuance Date in
the  aggregate  principal  amount  outstanding  at any one time not in excess of
$7,500,000  and which is  incurred  for lease  lines and  equipment,  inventory,
receivable and other similar asset-backed financing arrangements;

                           (4) Indebtedness incurred after the Issuance Date not
in excess of $15,000,000  aggregate principal amount outstanding at any one time
in  connection  with  a  strategic  alliance,   collaboration,   joint  venture,
partnership or other similar  arrangement  with another Person,  which strategic
alliance, collaboration, joint venture, partnership or other similar arrangement
relates to the  Company's  business as conducted  immediately  prior thereto and
which Person is engaged in a business  similar or related to the business of the
Company  or any  Subsidiary  as  long as (A) no  payment  of  principal  of such
Indebtedness  is  scheduled to be due prior to the date which is two years after
the Maturity Date and (B) in each instance  such  Indebtedness  is incurred in a
strategic alliance,  collaboration,  joint venture, partnership or other similar
arrangement in which the original  principal amount of such  Indebtedness is not
in excess of 25 percent of the total amount of cash  (including  proceeds to the
Company  or such  Subsidiary  of such  Indebtedness)  which the  Company or such
Subsidiary  is  receiving  or is  entitled  to  receive  at or before the stated
maturity of such  Indebtedness  on a basis that is not subject to any condition,
contingency, milestone or other event (other than the passage of time); and

                           (5) Indebtedness  which is subordinated to this Note,
the Other Notes and the Warrant Notes as to payment on the  Subordination  Terms
or on such other terms as shall have been approved in advance of the  incurrence
of such  Indebtedness  by the  Majority  Holders  as  evidenced  by the  written
approval  of the  Majority  Holders  given  prior  to  the  incurrence  of  such
Indebtedness  and for which no  payment of  principal  of such  Indebtedness  is
scheduled to be due prior to the date that is one year after the Maturity Date.

so long as in the case of  Indebtedness  permitted by the preceding  clauses (2)
through (5), at the time of incurrence of such  Indebtedness no Event of Default
has occurred and is continuing or would result from such incurrence and no event
which, with notice or passage of time, or both, would become an Event of Default
has occurred and is continuing or would result from such incurrence.

                  "Person" means any natural person,  partnership,  corporation,
limited liability  company,  trust,  incorporated  organization,  unincorporated
association  or  similar  entity  or  any  government,  governmental  agency  or
political subdivision.

                                      -35-
<PAGE>

                  "Pooling  Standards"  means  Opinion No. 16 of the  Accounting
Principles  Board  (or  any  successor  accounting  standard  of  the  Financial
Accounting  Standards Board (or any successor or replacement Person or board the
accounting  pronouncements  of which are applicable to issuers having a class of
securities  registered  pursuant to Section 12(b) or 12(g) of the 1934 Act)) and
any  applicable  requirements  of the  SEC  relating  to  pooling  of  interests
accounting for business combination transactions, in each case as in effect from
time to time.

                  "Preferred  Share Purchase  Rights" means the Preferred  Share
Purchase  Rights  issued or issuable  pursuant to the Rights  Agreement  (or any
similar right hereafter issued by the Company with respect to the Common Stock).

                  "QIB" means a  "qualified  institutional  buyer" as defined in
Rule 144A.

                  "Record  Date"  shall  mean,  with  respect  to any  dividend,
distribution or other  transaction or event in which the holders of Common Stock
have the right to receive any cash, securities or other property or in which the
Common Stock (or other  applicable  security) is exchanged for or converted into
any  combination  of cash,  securities  or other  property,  the date  fixed for
determination of stockholders entitled to receive such cash, securities or other
property  (whether  such date is fixed by the Board of  Directors or by statute,
contract or otherwise).

                  "Registration Repurchase Event" means the occurrence of any of
the following events:

                            (a)  the  Company  fails  to file  the  Registration
Statement within the 30-day period provided in Section 8(a)(1) of the Securities
Purchase Agreement;

                            (b) the SEC  Effective  Date shall not have occurred
on or before the date which is (i) 90 days after the Issuance Date, if the staff
of the SEC determines not to review the Registration  Statement or determines to
make only a limited review of the Registration Statement, or (ii) 135 days after
the Issuance Date, if the staff of the SEC determines to review the Registration
Statement (other than a limited review); or

                            (c)  counsel to the Holder  shall in good faith have
advised the Holder that, based on a review of the Registration  Statement,  such
counsel is unable to furnish to the Holder a letter,  to the effect set forth in
the first  paragraph  following  paragraph  (3) of Annex  VII to the  Securities
Purchase Agreement,  at any time that the Company is required by the Transaction
Documents  to cause its  counsel to furnish to the Holder an opinion in the form
of such Annex VII, unless prior to such time the Company shall have notified the
Holder that the  provisions of this clause (c) shall no longer be of any further
force or effect.

                  "Registration  Repurchase Price" means an amount in cash equal
to the sum of (1) the principal  amount of this Note to be repurchased  plus (2)
accrued  and  unpaid  interest  on such  principal  amount  to the  date of such
repurchase plus (3) accrued and unpaid Default  Interest,  if any, on the amount
referred to in the immediately preceding clause (2) at the rate provided in this
Note to the date of repurchase in accordance with Article V.

                  "Registration  Statement"  means  the  Registration  Statement
required to be filed by the Company with the SEC pursuant to Section  8(a)(1) of
the Securities  Purchase  Agreement  covering the resale of the shares of Common
Stock issuable or issued upon conversion of this Note.

                                      -36-
<PAGE>

                  "Repurchase  Event" means the occurrence of any one or more of
the following events:

                            (a) For any period of five consecutive  Trading Days
following  the date hereof  there shall be no reported  sale price of the Common
Stock on any of Nasdaq, the NYSE or the AMEX;

                            (b) The Common Stock ceases to be listed for trading
on Nasdaq, the NYSE or the AMEX;

                            (c) Any Fundamental Change;

                            (d) The adoption of any  amendment to the  Company's
Certificate of Incorporation (other than any certificate designating a series of
preferred  stock of the Company)  which  materially  and  adversely  affects the
rights of the  Holder or the  taking of any other  action by the  Company  which
materially and adversely affects the rights of the Holder;

                            (e) The  inability of the Holder for 20 Trading Days
(whether or not consecutive) during any period of 365 consecutive days occurring
on or after the SEC  Effective  Date to sell  shares of Common  Stock  issued or
issuable upon conversion of this Note pursuant to the Registration Statement (1)
by reason of the  requirements of the 1933 Act, the 1934 Act or any of the rules
or  regulations  under either thereof or (2) due to the  Registration  Statement
containing any untrue statement of material fact or omitting to state a material
fact required to be stated therein or necessary to make the  statements  therein
not misleading or other failure of the Registration Statement to comply with the
rules and  regulations  of the SEC;  or 

                            (f) Any Event of Default  specified in Article IV of
this Note.

                  "Repurchase  Price"  means  with  respect  to  any  repurchase
pursuant to  Sections  5.1 and 5.2 an amount in cash equal to the sum of (1) the
product  obtained by multiplying  (x) the sum of (A) the  outstanding  principal
amount of this Note plus (B)  accrued  and  unpaid  interest  on such  principal
amount to the date of such repurchase times (y) 110% plus (2) accrued and unpaid
Default Interest, if any, on the amount referred to in the immediately preceding
clause  (1)(x)(B)  at the  rate  provided  in  this  Note  to the  date  of such
repurchase.

                  "Restricted Securities" means securities that are not eligible
for  resale  pursuant  to Rule  144(k)  under  the  1933  Act (or any  successor
provision).

                  "Rights  Agreement"  means the Rights  Agreement,  dated as of
August 1, 1995,  by and  between the  Company  and Boston  EquiServe,  as Rights
Agent.

                  "Rule 144A" means Rule 144A as promulgated under the 1933 Act.

                  "SEC" means the Securities and Exchange Commission.

                  "SEC Effective Date" means the date on which the  Registration
Statement is first declared effective by the SEC.

                  "Securities"  shall  have  the  meaning  provided  in  Section
2.3(d).

                                      -37-
<PAGE>

                  "Securities  Purchase Agreement" means the Securities Purchase
and Exchange  Agreement,  dated as of March 19, 1999, by and between the Company
and the original Holder of this Note.

                  "Significant   Subsidiary"  means  a  Subsidiary  which  is  a
"significant  subsidiary," as that term is defined in Rule 1-02(w) of Regulation
S-X of the SEC as in effect on the date of this Agreement.

                  "Stock  Payment  Option"  shall have the  meaning  provided in
Section 1.1(a).

                  "Subordination  Terms" means with respect to any  Indebtedness
the terms of  subordination  set forth in Exhibit G hereto and which terms shall
be set forth in the instrument evidencing or governing such Indebtedness.

                  "Subsidiary"  means any corporation or other entity of which a
majority of the  capital  stock or other  ownership  interests  having  ordinary
voting  power to elect a majority  of the board of  directors  or other  persons
performing similar functions are at the time directly or indirectly owned by the
Company.

                  "Tender Offer" means a tender offer or exchange offer.

                  "Trading  Day"  means  a day  on  which  either  the  national
securities  exchange or Nasdaq which then  constitutes the principal  securities
market for the Common Stock is open for general trading.

                  "Transaction   Documents"  means  this  Note,  the  Securities
Purchase Agreement,  the Warrant Notes, the Warrants,  and the other agreements,
instruments and documents contemplated hereby and thereby.

                  "Trigger  Event"  shall have the  meaning  provided in Section
2.3(d).

                  "Trust  Agreement"  means the  Trust  Agreement  entered  into
between the Company and the  Trustee,  as trustee for the benefit of the holders
from time to time of this Note, the Other Notes and the Warrant  Notes,  for the
purposes  and  otherwise  in  accordance  with  Article  VI of this Note and the
comparable provisions of the Other Notes and the Warrant Notes.

                  "Trustee"  means the trustee  appointed  and acting  under the
Trust Agreement, who shall be a Person approved by the Majority Holders.

                  "Warrant  Notes" means the  Company's  12% Senior  Convertible
Notes issuable or issued pursuant to the Warrants.

                  "Warrants"  means the  Company's 12% Senior  Convertible  Note
Purchase Warrants issued pursuant to the Securities  Purchase  Agreement and the
Other Securities Purchase Agreements.

                                  ARTICLE VIII

                                  MISCELLANEOUS


                                      -38-
<PAGE>

         8.1 Failure or Indulgency  Not Waiver.  No failure or delay on the part
of the Holder in the exercise of any power,  right or privilege  hereunder shall
operate as a waiver  thereof,  nor shall any single or partial  exercise  of any
such power,  right or privilege preclude other or further exercise thereof or of
any other right, power or privileges. All rights and remedies existing hereunder
are  cumulative  to, and not  exclusive  of, any  rights or  remedies  otherwise
available.

         8.2 Notices.  Except as otherwise  specifically  provided  herein,  any
notice  herein  required or permitted to be given shall be in writing and may be
personally served, sent by telephone line facsimile transmission or delivered by
courier and shall be deemed to have been given upon  receipt.  For the  purposes
hereof,  the address and facsimile line transmission  number of the Holder shall
be  furnished  by the Holder for such  purpose  and shown on the  records of the
Company;  and the address of the Company  shall be SUGEN,  Inc.,  230 East Grand
Avenue, South San Francisco,  California 94080, Attention: Senior Vice President
and Chief Financial Officer facsimile line transmission number (650) 553-8310. A
copy of any notice to the  Company  pursuant to this Note shall also be provided
to Cooley  Godward  LLP,  3000 El Camino  Real,  Palo  Alto,  California  94306,
Attention:  Alan C. Mendelson, Esq. and Suzanne Sawochka Hooper, Esq. (telephone
line facsimile  transmission  number (650) 857-0663).  The Holder or the Company
may change its address for service by service of written  notice to the other as
herein provided.

         8.3 Amendment Provision. Neither this Note or any Other Note or Warrant
Note nor any terms  hereof or thereof  may be  changed,  waived,  discharged  or
terminated  unless such change,  waiver,  discharge or termination is in writing
signed by the Majority Holders,  provided that no such change, waiver, discharge
or termination  shall,  without the consent of the Holder and the holders of the
Other Notes and Warrant Notes affected  thereby,  (i) extend the scheduled final
maturity of this Note or any Other Note or Warrant  Note,  or reduce the rate or
extend the time of payment of  interest  (other  than as a result of waiving the
applicability of any post-default  increase in interest rates) hereon or thereon
or reduce the  principal  amount  hereof or thereof or the  Optional  Redemption
Consideration,  Repurchase Price or Registration  Repurchase  Price, (ii) amend,
modify or waive any provision of this Section 8.3,  (iii) reduce any  percentage
specified in, or otherwise  modify,  the definition of Majority  Holders or (iv)
except as provided in this Note, change the method of calculating the Conversion
Price in a manner adverse to the Holder.

         8.4 Assignability.  This Note shall be binding upon the Company and its
successors, and shall inure to the benefit of and be binding upon the Holder and
its successors and permitted  assigns.  The Company may not assign its rights or
obligations under this Note.

         8.5  Certain  Expenses.  The Company  shall pay on demand all  expenses
incurred by the Holder,  including reasonable attorneys' fees and expenses, as a
consequence  of, or in  connection  with (x) any default or breach of any of the
Company's  obligations  set  forth  in the  Transaction  Documents  and  (y) the
enforcement or  restructuring  of any right of,  including the collection of any
payments due, the Holder under the Transaction  Documents,  including any action
or proceeding  relating to such  enforcement  or any order,  injunction or other
process seeking to restrain the Company from paying any amount due the Holder.

         8.6 Governing  Law. This Note shall be governed by the internal laws of
the State of California, without regard to the principles of conflict of laws.

         8.7  Transfer  of  Note.  This  Note  has  not  been  and is not  being
registered under the provisions of the 1933 Act or any state securities laws and
this Note may not be transferred

                                      -39-
<PAGE>

prior to the date which is two years after the Issuance  Date unless (1) (A) the
transferee is an "accredited investor" as defined in Regulation D under the 1933
Act and (B) the  Holder  shall  have  delivered  to the  Company  an  opinion of
counsel, reasonably satisfactory in form, scope and substance to the Company, or
(2) this Note is  transferred  to a QIB in  accordance  with Rule  144A,  to the
effect that this Note may be sold or transferred without  registration under the
1933 Act.  Before any transfer of this Note prior to the date which is two years
after the Issuance Date, the transferee shall have represented in writing to the
Company that such  transferee  has  requested  and received from the Company all
information  relating  to  the  business,  properties,   operations,   condition
(financial or other),  results of operations or prospects of the Company  deemed
relevant  by such  transferee;  that  such  transferee  has  been  afforded  the
opportunity to ask questions of the Company concerning the foregoing and has had
the  opportunity  to  obtain  and  review  the  Registration  Statement  and the
prospectus  included  therein,  each as amended or  supplemented  to the date of
transfer to such transferee,  and the reports and other  information  concerning
the Company  which at the time of such  transfer  have been filed by the Company
with the SEC pursuant to the 1934 Act and which are incorporated by reference in
such prospectus as of the date of such transfer. If such transfer is intended to
assign the rights and obligations under Sections 5(a), 5(b), 8, 9, and 10 of the
Securities  Purchase  Agreement,  such  transfer  shall  otherwise  be  made  in
compliance with Section 10.7 of the Securities Purchase Agreement.

                  (b) Upon any  transfer  of a this Note to a QIB in  accordance
with Rule 144A,  and upon receipt of this Note,  together with a  certification,
substantially  in the form attached to this Note,  from the transferor  that the
transfer  is  being  made in  compliance  with  Rule  144A  (or  other  evidence
satisfactory to the Company), the Company shall permit the Note issued upon such
transfer to be held by the  Depositary,  and the Company shall cancel this Note;
provided however, that no such Note issued upon transfer of this Note in respect
of which the  Company  or an  Affiliate  of the  Company  holds  any  beneficial
interest shall be so held by the Depositary  until such Note is freely  tradable
in accordance  with Rule 144(k) under the 1933 Act;  provided  further  however,
that the Company shall issue a Note  registered in the name of the owner thereof
upon any transfer of a beneficial  interest in this Note while registered in the
name of the Depositary to the Company or any Affiliate of the Company.

         8.8 Enforceable Obligation. The Company represents and warrants that at
the time of the  original  issuance of this Note it received  the full  purchase
price  payable  pursuant to the  Securities  Purchase  Agreement in an amount at
least equal to the original principal amount of this Note, and that this Note is
an  enforceable  obligation  of the Company  which is not subject to any offset,
reduction, counterclaim or disallowance of any sort.

         8.9 Note Register;  Replacement of Notes.  The Company shall maintain a
register  showing the names,  addresses and telephone line facsimile  numbers of
the Holder and the registered holders of the Other Notes. The Company shall also
maintain a facility for the registration of transfers of this Note and the Other
Notes and at which this Note and the Other Notes may be surrendered for split up
into instruments of smaller denominations or for combination into instruments of
larger  denominations.  Upon  receipt  by the  Company  of  evidence  reasonably
satisfactory  to it of the  ownership  of and the loss,  theft,  destruction  or
mutilation of this Note and (a) in the case of loss,  theft or  destruction,  of
indemnity from the Holder  reasonably  satisfactory  in form to the Company (and
without the  requirement to post any bond or other  security) or (b) in the case
of mutilation,  upon surrender and  cancellation  of this Note, the Company will
execute and deliver to the Holder a new Note of like tenor.  In connection  with
the issuance of any such new Note, the Holder shall pay or reimburse the Company
for the

                                      -40-
<PAGE>

reasonable and documented  attorneys' fees and expenses  incurred by the Company
in connection therewith (but not in excess of $500.00 for each such issuance).

         8.10 Payment of Note on Redemption or Repurchase; Deposit of Redemption
or Repurchase  Price, Etc. If this Note is to be redeemed as provided in Section
1.2 or this Note or any portion of this Note is to be repurchased as provided in
Sections  5.1 and 5.2 or  Section  5.3 and any  notice  required  in  connection
therewith  shall have been given as provided  therein and the Company shall have
otherwise complied with the requirements of this Note with respect thereto, then
this Note or the portion of this Note to be so redeemed or repurchased  and with
respect to which any such notice has been given shall  become due and payable on
the  date  stated  in  such  notice  at  the  applicable   Optional   Redemption
Consideration,  Repurchase Price or Registration  Repurchase Price. On and after
the  Optional  Redemption  Date or  repurchase  date so stated  in such  notice,
provided that the Company shall have deposited with an Eligible Bank on or prior
to such Optional  Redemption Date or repurchase date, an amount and Common Stock
Warrants sufficient to pay the applicable  Optional Redemption  Consideration or
an amount  sufficient to pay the  applicable  Repurchase  Price or  Registration
Repurchase  Price,  as the case may be,  interest on this Note or the portion of
this Note to be so redeemed or repurchased shall cease to accrue,  and this Note
or such portion  hereof shall be deemed not to be  outstanding  and shall not be
entitled to any benefit  with respect to principal of or interest on the portion
to be so redeemed or repurchased  except to receive  payment and delivery of the
applicable Optional Redemption  Consideration,  Repurchase Price or Registration
Repurchase  Price.  On  presentation  and surrender of this Note or such portion
hereof,  this  Note  or the  specified  portion  hereof  shall  be  redeemed  or
repurchased  at the applicable  Optional  Redemption  Consideration,  Repurchase
Price or  Registration  Repurchase  Price.  If a  portion  of this Note is to be
repurchased,  upon surrender of this Note to the Company in accordance  with the
terms  hereof,  the Company  shall  execute  and  deliver to the Holder  without
service charge, a new Note or Notes,  having the same date hereof and containing
identical  terms  and  conditions,  in such  denomination  or  denominations  as
requested by the Holder in aggregate  principal amount equal to, and in exchange
for,  the  unrepurchased  portion  of the  principal  amount  of  this  Note  so
surrendered.



                [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]



                                      -41-
<PAGE>

                  IN WITNESS  WHEREOF,  the  Company  has caused this Note to be
signed  in its name by its duly  authorized  officer  on the day and in the year
first above written.

                                   SUGEN, INC.



                                   By:__________________________________________
                                                     James L. Knighton
                                                 Senior Vice President and
                                                  Chief Financial Officer




                                      -42-
<PAGE>

                                   ASSIGNMENT

         For value received  _________________________ hereby sell(s), assign(s)
and transfer(s) unto _________________________ (Please insert social security or
other       Taxpayer        Identification       Number       of       assignee:
______________________________)   the  within  Note,   and  hereby   irrevocably
constitutes and appoints _________________________ attorney to transfer the said
Note on the  books  of the  Company,  with  full  power of  substitution  in the
premises.

         In connection  with any transfer of the Note within the period prior to
the  expiration  of the holding  period  applicable  to sales thereof under Rule
144(k) under the 1933 Act (or any successor  provision) (other than any transfer
pursuant to a registration  statement that has been declared effective under the
1933 Act), the undersigned confirms that such Note is being transferred:

         [ ]   To SUGEN, Inc. or a subsidiary thereof; or

         [ ]   To a QIB pursuant to and in compliance with Rule 144A; or

         [ ]   To an "accredited  investor"  pursuant to and in compliance  with
               the 1933 Act; or

         [ ]   Pursuant to and in compliance with Rule 144 under the 1933 Act;

and unless the box below is  checked,  the  undersigned  confirms  that,  to the
knowledge  of  the  undersigned,  such  Note  is  not  being  transferred  to an
"affiliate"  of the  Company  as  defined  in Rule  144  under  the 1933 Act (an
"Affiliate").

         [ ]   The transferee is an Affiliate of the Company.

         Capitalized  terms  used in this  Assignment  and not  defined  in this
Assignment shall have the respective meanings provided in the Note.

Dated:_____________________________           NAME:_____________________________

                                              __________________________________
                                                          Signature(s)



                                      -43-
<PAGE>


                                                                       EXHIBIT A
                                                                         TO NOTE


                              NOTICE OF CONVERSION
                     OF 12% SENIOR CONVERTIBLE NOTE DUE 2002
                                 OF SUGEN, INC.
<TABLE>
<CAPTION>
- ---------------------------------------------------------------------------------------
<S>                                                <C>
To: SUGEN, Inc.                                    with a copy to:
    230 East Grand Avenue
    South San Francisco, California 94063-4720     Cooley Godward LLP
    Attention:  Senior Vice President and          5 Palo Alto Square
                 Chief Financial Officer           3000 El Camino Real
                                                   Palo Alto, California 94306
    Primary Facsimile No.:  (650) 553-8310         Attn:  Suzanne Sawochka Hooper, Esq.
    Alternate Facsimile No. (if primary not        Facsimile No.:  (650) 857-0663
    functioning): (650) 553-8301

    BankBoston N.A.,
    as Issuing Agent
    150 Royall Street
    Canton, Massachusetts 02021
    Attention:  Ms. Dawn Coe
                 Special Issuances
    Facsimile No.:  (781) 575-2393
- ---------------------------------------------------------------------------------------
</TABLE>
         1.  Pursuant to the terms of the 12% Senior  Convertible  Note due 2002
(the "Note"),  the undersigned hereby elects to convert  $_______________ of the
Note,  equal  to the  sum of  $_______________  principal  amount  of the  Note,
$_______________  of accrued and unpaid  interest on such  principal  amount and
$_______________  of Default  Interest  on such  interest  into shares of Common
Stock of SUGEN,  Inc., a Delaware  corporation (the "Company"),  at a Conversion
Price per share equal to $_______________. Capitalized terms used herein and not
otherwise defined herein have the respective meanings provided in the Note.

         2. The number of shares of Common Stock issuable upon the conversion of
the  Note to  which  this  Notice  relates  is  _______________(the  "Conversion
Shares").

         3. Please  issue a  certificate  or  certificates  for  _______________
shares  of  Common  Stock in the  name(s)  specified  immediately  below  or, if
additional space is necessary, on an attachment hereto:

_____________________________________  _________________________________________
Name                                   Name
_____________________________________  _________________________________________
Address                                Address
_____________________________________  _________________________________________
SS or Tax ID Number                    SS or Tax ID Number

Delivery Instructions
for Common Stock:_______________________________________________________________

         4. The Holder hereby  represents  and warrants that it has complied and
will comply with the applicable  requirements of Sections 8(c)(3) and 8(c)(5) of
the  Securities  Purchase


                                      A-44
<PAGE>

Agreement  with  respect  to the  shares  of  Common  Stock  issuable  upon  the
conversion of the Note to which this Notice relates.

         5. If the shares of Common Stock  issuable upon  conversion of the Note
have not been registered for resale under the Securities Act of 1933, as amended
(the  "Act"),  and  the  provisions  of  Rule  144(k)  under  the  1933  Act are
inapplicable to the undersigned  with respect to the Conversion  Shares relating
to this Notice,  the undersigned  represents and warrants that (i) the shares of
Common  Stock  issuable  upon the  conversion  of the Note to which this  Notice
relates are being acquired for the account of the  undersigned  for  investment,
and not with a view to,  or for  resale in  connection  with,  the  distribution
thereof,  and that the undersigned  has no present  intention of distributing or
reselling such shares and (ii) the  undersigned  is an "accredited  investor" as
defined in  Regulation  D under the 1933 Act. If the  provisions  of Rule 144(k)
under the 1933 Act are  inapplicable  to the  undersigned  with  respect  to the
Conversion Shares relating to this Notice,  the undersigned  further agrees that
(A) such  shares  shall not be sold or  transferred  unless (i) they first shall
have been registered  under the 1933 Act and applicable state securities laws or
(ii) the  Company  shall have been  furnished  with an opinion of legal  counsel
reasonably  satisfactory  in form,  scope and  substance  to the  Company to the
effect that such sale or transfer is exempt from the  registration  requirements
of the 1933 Act and (B) until such shares are registered under the 1933 Act, the
Company may place a legend on the  certificate(s)  for the shares to that effect
and place a stop-transfer restriction in its records relating to the shares.


                                        NAME:___________________________________

Date_________________________________   ________________________________________
                                              Signature of Registered Holder
                                              (Must be signed exactly as name
                                                   appears in the Note.)



                                      A-45
<PAGE>


                                                                       EXHIBIT B
                                                                         TO NOTE

                                   SUGEN, INC.

                           OPTIONAL REDEMPTION NOTICE
              (Section 1.2 of 12% Senior Convertible Note due 2002)

TO:________________________________________________________________
                                (Name of Holder)

         1.  Pursuant to the terms of the 12% Senior  Convertible  Note due 2002
(the  "Note"),  SUGEN,  Inc., a Delaware  corporation  (the  "Company"),  hereby
notifies  the  above-named  Holder that the Company is  exercising  its right to
redeem the Note in accordance with Section 1.2 of the Note as set forth below:

                  (i) The cash  portion  of  Optional  Redemption  Consideration
(based on the principal  amount of the Note  outstanding on the date this Notice
is given) is $_____________.

                  (ii) The Common Stock Warrant  issuable  upon such  redemption
(based on the principal  amount of the Note  outstanding on the date this notice
is given)  initially  will  entitle  the holder to purchase  ________  shares of
Common Stock at a price of $_________ per share.

                  (iii)    The Optional Redemption Date is _____________.

         2. Capitalized  terms used herein and not otherwise defined herein have
the respective meanings provided in the Note.

Date_________________________________    SUGEN, INC.



                                         By:____________________________________

                                         Title:_________________________________




                                      B-46

<PAGE>

                                                                       EXHIBIT C
                                                                         TO NOTE

THIS  WARRANT  HAS NOT  BEEN  REGISTERED  UNDER  THE  SECURITIES  ACT OF 1933 OR
APPLICABLE  STATE  SECURITIES  LAWS  AND  MAY NOT BE  SOLD,  OFFERED  FOR  SALE,
TRANSFERRED  OR OTHERWISE  DISPOSED OF UNLESS (1) IT HAS BEEN  REGISTERED  UNDER
THOSE  LAWS,  (2) THE  COMPANY  HAS  RECEIVED  AN OPINION OF COUNSEL  REASONABLY
SATISFACTORY TO IT THAT AN EXEMPTION FROM REGISTRATION  UNDER EACH OF THOSE LAWS
IS  AVAILABLE  OR (3)  SUCH  SALE,  TRANSFER  OR OTHER  DISPOSITION  IS TO A QIB
PURSUANT TO RULE 144A.

THIS  WARRANT IS ISSUED IN  CONNECTION  WITH  SECURITIES  ISSUED  PURSUANT  TO A
SECURITIES PURCHASE AND EXCHANGE  AGREEMENT,  DATED AS OF MARCH 19, 1999, BY AND
BETWEEN THE COMPANY AND THE  ORIGINAL  HOLDER OF THIS  WARRANT,  AS AMENDED FROM
TIME TO TIME,  AND THE HOLDER OF THIS WARRANT AND THIS WARRANT MAY BE SUBJECT TO
CERTAIN OF THE TERMS OF THE SECURITIES PURCHASE AND EXCHANGE AGREEMENT.

THIS WARRANT MAY NOT BE TRANSFERRED EXCEPT AS PROVIDED IN SECTION 16.

No. WB-1                            Right to Purchase [BEFORE  ISSUANCE,  INSERT
                                    NUMBER DETERMINED IN ACCORDANCE WITH SECTION
                                    5 OF 12% SENIOR  CONVERTIBLE  NOTE  PURCHASE
                                    WARRANT OR DEFINITION OF OPTIONAL REDEMPTION
                                    CONSIDERATION IN NOTE, AS APPLICABLE] Shares
                                    of Common Stock of SUGEN, Inc.

                                   SUGEN, INC.

                          Common Stock Purchase Warrant

         SUGEN, INC., a Delaware  corporation,  hereby certifies that, for value
received,  [INSERT  NAME OF HOLDER] or  registered  assigns (the  "Holder"),  is
entitled,  subject to the terms set forth below, to purchase from the Company at
any time or from time to time after the date hereof,  and before 5:00 p.m.,  New
York City time,  on the  Expiration  Date (such  capitalized  term and all other
capitalized  terms used herein having the respective  meanings provided herein),
[BEFORE  ISSUANCE,  INSERT NUMBER DETERMINED IN ACCORDANCE WITH SECTION 5 OF 12%
SENIOR  CONVERTIBLE NOTE PURCHASE  WARRANT OR DEFINITION OF OPTIONAL  REDEMPTION
CONSIDERATION  IN NOTE, AS APPLICABLE]  fully paid and  nonassessable  shares of
Common  Stock at a purchase  price per share equal to the  Purchase  Price.  The
number of such  shares of Common  Stock and the  Purchase  Price are  subject to
adjustment as provided in this Warrant.

         As used  herein the  following  capitalized  terms,  unless the context
otherwise requires, have the following respective meanings:



                                      C-47
<PAGE>

         "Aggregate  Purchase  Price"  means at any time an amount  equal to the
product  obtained by multiplying  (x) the Purchase Price times (y) the number of
shares of Common Stock for which this Warrant may be exercised at such time.

         "AMEX" means the American Stock Exchange, Inc.

         "Board of Directors" means the Board of Directors of the Company.

         "Board  Resolution"  means  a copy  of a  resolution  certified  by the
Secretary or an Assistant  Secretary of the Company to have been duly adopted by
the Board of  Directors,  or duly  authorized  committee  thereof (to the extent
permitted by applicable  law), and to be in full force and effect on the date of
such certification, and delivered to the Holder.

         "Business Day" means any day other than a Saturday,  Sunday or a day on
which commercial banks in The City of New York are authorized or required by law
or executive order to remain closed.

         "Common Stock" includes the Company's  Common Stock, par value $.01 per
share,  and the related  Preferred Share Purchase Rights (and any similar rights
issued with respect to the Common Stock) as  authorized on the date hereof,  and
any other  securities  into which or for which the Common  Stock or the  related
Preferred  Share Purchase  Rights (and any similar rights issued with respect to
the  Common  Stock)  may  be  converted  or  exchanged  pursuant  to a  plan  of
recapitalization,  reorganization,  merger,  sale of assets or otherwise and any
stock (other than Common Stock) and other securities of the Company or any other
Person which the Holder at any time shall be entitled to receive,  or shall have
received,  on the exercise of this Warrant,  in lieu of or in addition to Common
Stock.

         "Common Stock Equivalents" means any warrant,  option,  subscription or
purchase right with respect to shares of Common Stock, any security  convertible
into,  exchangeable  for, or otherwise  entitling the holder thereof to acquire,
shares of Common Stock or any warrant,  option,  subscription  or purchase right
with respect to any such convertible, exchangeable or other security.

         "Company"  shall include  SUGEN,  Inc. and any  corporation  that shall
succeed to or assume the obligation of SUGEN, Inc.  hereunder in accordance with
the terms hereof.

         "Current  Fair Market Value" means when used with respect to the Common
Stock as of a specified  date with  respect to each share of Common  Stock,  the
average  of the  closing  prices  of the  Common  Stock  sold on all  securities
exchanges  (including the Nasdaq National Market and the Nasdaq SmallCap Market)
on which the Common  Stock may at the time be listed,  or, if there have been no
sales on any such  exchange  on such day,  the  average of the  highest  bid and
lowest asked prices on all such exchanges at the end of such day, or, if on such
day the Common Stock is not so listed, the average of the representative bid and
asked prices  quoted in the NASDAQ  System as of 4:00 p.m.,  New York City time,
or, if on such day the  Common  Stock is not quoted in the  NASDAQ  System,  the
average of the  highest bid and lowest  asked price on such day in the  domestic
over-the-counter   market  as  reported  by  the  National   Quotation   Bureau,
Incorporated,  or any similar successor organization, in each such case averaged
over a period of five Trading Days consisting of the day as of which the Current
Fair Market Value of Common Stock is being  determined  (or if such day is not a
Trading Day, the Trading Day next preceding  such day) and the four  consecutive
Trading  Days prior to such day.  If on the date for which  Current  Fair Market
Value is to be  determined  the  Common  Stock is not  listed on any


                                      C-48
<PAGE>

securities  exchange  or quoted  in the  NASDAQ  System or the  over-the-counter
market,  the Current  Fair Market  Value of Common Stock shall be the greater of
(i) the  highest  price per share of Common  Stock at which the Company has sold
shares of Common Stock or Common Stock Equivalents  within 365 days prior to the
date of such  determination  and (ii) the  highest  price  per  share  which the
Company  could then obtain from a willing  buyer (not an employee or director of
the Company at the time of determination) for shares of Common Stock sold by the
Company, from authorized but unissued shares, as determined in good faith by the
Board of Directors.

         "Current  Market Price" shall mean the arithmetic  average of the daily
Market  Prices per share of Common  Stock for the ten  consecutive  Trading Days
immediately prior to the date in question;  provided,  however,  that (1) if the
"ex" date (as  hereinafter  defined)  for any event  (other than the issuance or
distribution  requiring  such  computation)  that  requires an adjustment to the
Purchase Price pursuant to Section 3(a),  (b), (c), (d), (e), (f), or (g) occurs
during such ten consecutive  Trading Days, the Market Price for each Trading Day
prior to the "ex" date for such other event  shall be  adjusted  by  multiplying
such  Market  Price  by the same  fraction  by which  the  Purchase  Price is so
required to be adjusted  as a result of such other  event,  (2) if the "ex" date
for  any  event  (other  than  the  issuance  or  distribution   requiring  such
computation)  that  requires an  adjustment  to the Purchase  Price  pursuant to
Section  3(a),  (b), (c), (d), (e), (f), or (g) occurs on or after the "ex" date
for the issuance or distribution requiring such computation and prior to the day
in  question,  the Market  Price for each Trading Day on and after the "ex" date
for such other event shall be adjusted by  multiplying  such Market Price by the
reciprocal  of the  fraction  by which the  Purchase  Price is so required to be
adjusted  as a result  of such  other  event,  and (3) if the "ex"  date for the
issuance  or  distribution  requiring  such  computation  is prior to the day in
question,  after taking into account any adjustment  required pursuant to clause
(1) or (2) of this  proviso,  the Market  Price for each Trading Day on or after
such "ex" date shall be  adjusted  by adding  thereto the amount of any cash and
the fair  market  value (as  determined  by the Board of  Directors  in a manner
consistent with any  determination of such value for purposes of Section 3(d) or
(f),  whose   determination  shall  be  conclusive  and  described  in  a  Board
Resolution) of the evidences of indebtedness,  shares of capital stock or assets
being  distributed  applicable  to one share of Common  Stock as of the close of
business on the day before such "ex" date. For purposes of any computation under
Section 3(f),  the Current Market Price of the Common Stock on any date shall be
deemed to be the  arithmetic  average  of the daily  Market  Prices per share of
Common Stock for such day and the next two  succeeding  Trading Days;  provided,
however,  that if the "ex"  date for any  event  (other  than the  Tender  Offer
requiring such  computation) that requires an adjustment to the Conversion Price
pursuant to Section 3(a), (b), (c), (d), (e), (f), or (g) occurs on or after the
Expiration Time for the Tender Offer requiring such computation and prior to the
day in  question,  the Market  Price for each  Trading Day on and after the "ex"
date for such other event shall be adjusted by multiplying  such Market Price by
the  reciprocal of the fraction by which the Purchase Price is so required to be
adjusted as a result of such other event.  For purposes of this  paragraph,  the
term "ex" date,  (1) when used with  respect to any  issuance  or  distribution,
means the first date on which the  Common  Stock  trades,  regular  way,  on the
relevant  exchange or in the  relevant  market  from which the Market  Price was
obtained  without the right to receive such issuance or  distribution,  (2) when
used with respect to any  subdivision  or combination of shares of Common Stock,
means the first date on which the Common  Stock  trades,  regular  way,  on such
exchange  or in  such  market  after  the  time at  which  such  subdivision  or
combination  becomes  effective,  and (3) when used with  respect  to any Tender
Offer means the first date on which the Common  Stock  trades,  regular  way, on
such exchange or in such market after the Expiration  Time of such Tender Offer.
Notwithstanding the foregoing,  whenever successive  adjustments to the Purchase
Price are called for  pursuant to Section 3, such  adjustments  shall be made to
the Current  Market Price as


                                      C-49
<PAGE>


may be necessary or  appropriate  to  effectuate  the intent of Section 3 and to
avoid unjust or inequitable  results as determined in good faith by the Board of
Directors.

         "Expiration Date" means March 31, 2004.

         "Expiration Time" shall have the meaning provided in Section 3(f).

         "Issuance  Date"  shall  mean the  date of  original  issuance  of this
Warrant.

         "Market  Price"  means  with  respect  to any  security  on any day the
closing bid price of such  security on such day on the Nasdaq or the NYSE or the
AMEX, as  applicable,  or, if such security is not listed or admitted to trading
on the  Nasdaq,  the NYSE or the  AMEX,  on the  principal  national  securities
exchange  or  quotation  system on which  such  security  is quoted or listed or
admitted to trading, in any such case as reported by Bloomberg,  L.P. or, if not
quoted or listed or admitted to trading on any national  securities  exchange or
quotation  system,  the  average  of the  closing  bid and asked  prices of such
security on the over-the-counter  market on the day in question,  as reported by
the National  Quotation Bureau  Incorporated,  or a similar  generally  accepted
reporting  service,  or if not so available,  in such manner as furnished by any
New York Stock  Exchange  member firm selected from time to time by the Board of
Directors for that purpose,  or a price determined in good faith by the Board of
Directors,  whose  determination  shall be  conclusive  and described in a Board
Resolution.

         "Newly Issued Shares" shall have the meaning provided in Section 3(g).

         "1934 Act" means the Securities Exchange Act of 1934, as amended.

         "1933 Act" means the Securities Act of 1933, as amended.

         "Notes"  shall  mean the 12% Senior  Convertible  Notes due 2002 of the
Company  issued  pursuant to the  Securities  Purchase  Agreement  and the Other
Securities Purchase Agreements.

         "Note Warrants" means the 12% Senior Convertible Note Purchase Warrants
issued by the Company  pursuant to the  Securities  Purchase  Agreement  and the
Other Securities Purchase Agreements.

         "NYSE" means the New York Stock Exchange, Inc.

         "Other Securities  Purchase  Agreements"  means the several  Securities
Purchase  and  Exchange  Agreements,  dated  as of the  date  of the  Securities
Purchase  Agreement,  by and between the  Company and the several  buyers  named
therein.

         "Other  Warrants" shall mean the Common Stock Purchase  Warrants (other
than  this  Warrant)  issued  or  issuable  pursuant  to the  Notes  or the Note
Warrants.

         "Person" means any natural person,  corporation,  partnership,  limited
liability company, trust, incorporated organization, unincorporated association,
or  similar  entity  or  any  government,   governmental   agency  or  political
subdivision.

         "Preferred  Share Purchase  Rights" means the Preferred  Share Purchase
Rights  issued or  issuable  pursuant  to the Rights  Agreement  (or any similar
rights hereafter issued by the Company with respect to the Common Stock).


                                      C-50
<PAGE>

         "Purchase Price" means $[PRIOR TO ISSUANCE,  INSERT CONVERSION PRICE OF
NOTES IN EFFECT  IMMEDIATELY  PRIOR TO ISSUANCE OR  CONVERSION  PRICE OF WARRANT
NOTES THAT WOULD BE IN EFFECT  IMMEDIATELY  PRIOR TO ISSUANCE,  AS  APPLICABLE],
subject to  adjustment  as provided in this  Warrant.

         "QIB" means a "qualified institutional buyer" as defined in Rule 144A.

         "Record Date" shall mean, with respect to any dividend, distribution or
other  transaction  or event in which the holders of Common Stock have the right
to receive any cash,  securities or other  property or in which the Common Stock
(or  other  applicable   security)  is  exchanged  for  or  converted  into  any
combination  of  cash,  securities  or  other  property,   the  date  fixed  for
determination of stockholders entitled to receive such cash, securities or other
property  (whether  such date is fixed by the Board of  Directors or by statute,
contract or otherwise).

         "Restricted  Securities"  means  securities  that are not  eligible for
resale pursuant to Rule 144(k) under the 1933 Act (or any successor provision).

         "Rights  Agreement" means the Rights  Agreement,  dated as of August 1,
1995,  by and  between the Company and Boston  EquiServe,  as Rights  Agent,  as
amended from time to time in accordance with its terms.

         "Rule 144A" means Rule 144A as promulgated under the 1933 Act.

         "SEC" means the Securities and Exchange Commission.

         "Securities" shall have the meaning provided in Section 3(d).

         "Securities  Purchase  Agreement"  means the  Securities  Purchase  and
Exchange  Agreement,  dated as of March 19, 1999, by and between the Company and
the original  Holder of the Note or Note Warrant  pursuant to which this Warrant
was issued.

         "Subsidiary"  means any corporation or other entity of which a majority
of the capital stock or other ownership  interests  having ordinary voting power
to elect a  majority  of the  board of  directors  or other  persons  performing
similar functions are at the time directly or indirectly owned by the Company.

         "Tender Offer" means a tender offer or exchange offer.

         "Trading  Day"  means a day on which  either  the  national  securities
exchange or Nasdaq which then  constitutes the principal  securities  market for
the Common Stock is open for general trading.

         "Trigger Event" shall have the meaning provided in Section 3(d).

         "Warrant  Notes"  means the  Company's  12%  Senior  Convertible  Notes
issuable or issued pursuant to the Note Warrants.

         1.       Exercise of Warrant.

         1.1 Exercise. This Warrant may be exercised by the Holder in full or in
part at any time or from time to time during the  exercise  period  specified in
the first paragraph  hereof until 


                                      C-51
<PAGE>

the Expiration Date by (x) surrendering this Warrant to the Company,  (y) giving
a subscription  form in the form annexed hereto (duly executed by the Holder) to
the Company,  and (z) making  payment,  in cash or by certified or official bank
check  payable to the order of the Company,  or by wire transfer of funds to the
account of the Company,  in either case, in the amount  obtained by  multiplying
(a) the  number  of  shares  of Common  Stock  designated  by the  Holder in the
subscription  form by (b) the  Purchase  Price  then in effect.  On any  partial
exercise  the Company will  forthwith  issue and deliver to or upon the order of
the Holder a new Warrant or Warrants of like tenor, in the name of the Holder or
as the Holder (upon payment by the Holder of any applicable  transfer taxes) may
request,  providing  in the  aggregate  on the  face or  faces  thereof  for the
purchase  of the  number of shares of Common  Stock for which  such  Warrant  or
Warrants may still be exercised.  The  subscription  form may be  surrendered by
telephone line facsimile  transmission to such telephone  number for the Company
as shall have been specified in writing to the Holder by the Company;  provided,
however, that if the subscription form is given to the Company by telephone line
facsimile  transmission  the Holder shall send an original of such  subscription
form to the Company within ten Business Days after such  subscription form is so
given to the Company;  provided further,  however,  that any failure or delay on
the part of the Holder in giving such  original of any  subscription  form shall
not affect the validity or the date on which such  subscription form is so given
by telephone line facsimile transmission.

         1.2 Net Issuance. Notwithstanding anything to the contrary contained in
Section 1.1, the Holder may elect to exercise this Warrant, in whole or in part,
by  receiving  shares  of  Common  Stock  equal to the net  issuance  value  (as
determined  below) of this Warrant,  or any part hereof,  upon  surrender of the
subscription  form annexed  hereto (duly  executed by the Holder) to the Company
(followed by surrender of this Warrant to the Company  within three Trading Days
after  surrender of such  subscription  form),  in which event the Company shall
issue to the  Holder a number  of  shares of  Common  Stock  computed  using the
following formula:

                                       X = Y x (A - B)
                                           -----------
                                             A
where,

             X = the number of shares of Common Stock to be issued to the Holder

             Y = the number of shares of Common Stock  as to which this  Warrant
                 is to be exercised

             A = the  Current  Fair  Market  Value of one share of Common  Stock
                 calculated as of the last Trading Day immediately preceding the
                 exercise of this Warrant

             B = the Purchase Price

         2.  Delivery  of Stock  Certificates,  etc.,  on  Exercise.  As soon as
practicable  after the  exercise of this  Warrant,  and in any event within five
Trading Days thereafter, the Company at its expense (including the payment by it
of any  applicable  issue or stamp taxes) will cause to be issued in the name of
and delivered to the Holder, or as the Holder (upon payment by the Holder of any
applicable  transfer taxes) may direct,  a certificate or  certificates  for the
number of fully  paid and  nonassessable  shares  of  Common  Stock to which the
Holder  shall be  entitled on such  exercise,  in such  denominations  as may be
requested  by the Holder,  plus,  in lieu of any  fractional  share to which the
Holder would  otherwise be entitled,  cash equal to such fraction  multiplied by
the Current Fair Market Value of one share of Common Stock  calculated as of the


                                      C-52
<PAGE>

last Trading Day immediately preceding the date of such exercise,  together with
any other stock or other  securities  or any  property  (including  cash,  where
applicable)  to which the Holder is  entitled  upon such  exercise  pursuant  to
Section 1 or otherwise.  Upon exercise of this Warrant as provided  herein,  the
Company's  obligation  to issue and deliver the  certificates  for Common  Stock
shall be absolute and  unconditional,  irrespective of the absence of any action
by the Holder to enforce  the same,  any waiver or consent  with  respect to any
provision hereof,  the recovery of any judgment against any Person or any action
to  enforce  the same,  any  failure  or delay in the  enforcement  of any other
obligation  of  the  Company  to  the  Holder,  or  any  setoff,   counterclaim,
recoupment,  limitation or  termination,  or any breach or alleged breach by the
Holder or any other Person of any  obligation to the Company or any violation or
alleged violation of law by the Holder or any other Person,  and irrespective of
any other  circumstance  which  might  otherwise  limit such  obligation  of the
Company to the Holder in connection with such exercise.  If the Company fails to
issue and deliver the  certificates  for the Common Stock to the Holder pursuant
to the  first  sentence  of this  paragraph  as and when  required  to do so, in
addition  to any other  liabilities  the Company  may have  hereunder  and under
applicable  law, the Company shall pay or reimburse the Holder on demand for all
out-of-pocket expenses including, without limitation, fees and expenses of legal
counsel incurred by the Holder as a result of such failure.

         3.  Adjustments to Purchase Price. The Purchase Price and the number of
shares of Common  Stock which may be  purchased  upon  exercise of this  Warrant
shall be adjusted from time to time by the Company as follows:

                  (a) In case the Company  shall on or after the  Issuance  Date
pay a dividend or make a distribution to all holders of the  outstanding  Common
Stock in shares of Common Stock, then

                  (1) the Purchase Price in effect at the opening of business on
         the date following the date fixed for the determination of stockholders
         entitled  to  receive  such  dividend  or other  distribution  shall be
         reduced by  multiplying  such Purchase Price by a fraction of which the
         numerator shall be the number of shares of Common Stock  outstanding at
         the close of business  on the Record Date fixed for such  determination
         and the  denominator  shall be the sum of such number of shares and the
         total   number  of  shares   constituting   such   dividend   or  other
         distribution,  such reduction to become effective immediately after the
         opening of business on the day following the Record Date; and

                  (2) the  number  of shares  of  Common  Stock  for which  this
         Warrant  may  thereafter  be  exercised  that shall be in effect at the
         opening  of  business  on the date  following  the date  fixed  for the
         determination  of  stockholders  entitled to receive  such  dividend or
         other distribution shall be increased to a number equal to the quotient
         obtained  by  dividing  (x) the  Aggregate  Purchase  Price  in  effect
         immediately  prior to such adjustment in the Purchase Price pursuant to
         clause  (1) of  this  Section  3(a) by the  Purchase  Price  in  effect
         immediately  after such  adjustment in the Purchase  Price  pursuant to
         clause (1) of this Section 3(a).

If any dividend or  distribution  of the type  described in this Section 3(a) is
declared but not so paid or made,  the Purchase Price shall again be adjusted to
the  Purchase  Price  which  would  then  be  in  effect  if  such  dividend  or
distribution  had not been declared and the number of shares of Common Stock for
which this Warrant may thereafter be exercised shall again be adjusted  

                                      C-53
<PAGE>

(subject to  proportionate  adjustment  for any  intervening  exercises  of this
Warrant)  to the  number  which  would  then be in  effect if such  dividend  or
distribution had not been declared.

                  (b) In case the Company  shall on or after the  Issuance  Date
issue  rights or  warrants  (other than any rights or  warrants  (including  the
Preferred Share Purchase  Rights) referred to in Section 3(d)) to all holders of
its  outstanding  shares of Common Stock  entitling them (for a period  expiring
within  45 days  after  the date  fixed for the  determination  of  stockholders
entitled to receive such rights or warrants) to subscribe for or purchase shares
of Common  Stock at a price per share less than the Current  Market Price on the
Record Date fixed for the determination of stockholders entitled to receive such
rights or warrants, then

                  (1) the  Purchase  Price  shall be  adjusted  so that the same
         shall equal the price  determined by multiplying  the Purchase Price in
         effect at the opening of business on the date after such Record Date by
         a  fraction  of which the  numerator  shall be the  number of shares of
         Common Stock  outstanding  at the close of business on such Record Date
         plus the number of shares  which the  aggregate  offering  price of the
         total number of shares so offered would purchase at such Current Market
         Price,  and the  denominator  shall be the  number  of shares of Common
         Stock outstanding on the close of business on such Record Date plus the
         total  number  of  additional  shares of Common  Stock so  offered  for
         subscription or purchase; and

                  (2) the number of shares of Common  Stock which the Holder may
         thereafter  purchase  upon  exercise of this  Warrant at the opening of
         business  on the date after such Record  Date shall be  increased  to a
         number  equal to the quotient  obtained by dividing  (x) the  Aggregate
         Purchase Price in effect  immediately  prior to such  adjustment in the
         Purchase  Price  pursuant to clause (1) of this Section 3(b) by (y) the
         Purchase  Price in effect  immediately  after  such  adjustment  in the
         Purchase Price pursuant to Section 3(a)(1).

Such adjustment shall become effective immediately after the opening of business
on the day following  the Record Date fixed for  determination  of  stockholders
entitled to receive such rights or warrants. To the extent that shares of Common
Stock are not delivered pursuant to such rights or warrants, upon the expiration
or  termination  of such  rights  or  warrants,  the  Purchase  Price  shall  be
readjusted  to the  Purchase  Price  which  would  then  be in  effect  had  the
adjustments  made upon the issuance of such rights or warrants  been made on the
basis of  delivery  of only the  number  of  shares  of  Common  Stock  actually
delivered  and the number of shares of Common  Stock for which this  Warrant may
thereafter be exercised shall be readjusted (subject to proportionate adjustment
for any intervening exercises of this Warrant) to the number which would then be
in effect had the adjustments  made upon the issuance of such rights or warrants
been made on the basis of delivery of only the number of shares of Common  Stock
actually delivered. In the event that such rights or warrants are not so issued,
the Purchase  Price shall again be adjusted to be the Purchase Price which would
then be in  effect if such  Record  Date had not been  fixed  and the  number of
shares of Common Stock for which this Warrant may thereafter be exercised  shall
again be  adjusted  (subject to  proportionate  adjustment  for any  intervening
exercises  of this  Warrant)  to be the number  which would then be in effect if
such  Record  Date had not been  fixed.  In  determining  whether  any rights or
warrants  entitle the holder to subscribe for or purchase shares of Common Stock
at less than  such  Current  Market  Price,  and in  determining  the  aggregate
offering price of such shares of Common Stock, there shall be taken into account
any  consideration  received  for such  rights  or  warrants,  the value of such
consideration, if other than cash, to be determined by the Board of Directors.

                                      C-54
<PAGE>

                  (c) In case the outstanding shares of Common Stock shall on or
after the Issuance Date be subdivided  into a greater number of shares of Common
Stock, the Purchase Price in effect at the opening of business on the earlier of
the day following the day upon which such subdivision  becomes effective and the
day on which  "ex-"  trading of the Common  Stock  begins  with  respect to such
subdivision  shall  be  proportionately   reduced,   and  conversely,   in  case
outstanding  shares of Common Stock shall be combined  into a smaller  number of
shares of Common Stock,  the Purchase Price in effect at the opening of business
on the earlier of the day following the day upon which such combination  becomes
effective and the day on which "ex-" trading of the Common Stock with respect to
such combination  begins shall be proportionately  increased,  such reduction or
increase,  as the case may be, to become effective immediately after the opening
of  business  on the  earlier  of the day  following  the day  upon  which  such
subdivision or combination  becomes effective and the day on which "ex-" trading
of the Common Stock begins with respect to such  subdivision or combination.  If
the Purchase Price shall be reduced or increased  pursuant to this Section 3(c),
then  commencing at the time of such  reduction or increase the number of shares
of Common Stock for which this  Warrant may  thereafter  be  exercised  shall be
adjusted  to a  number  equal  to the  quotient  obtained  by  dividing  (x) the
Aggregate  Purchase  Price in  effect  immediately  prior to such  reduction  or
increase in the Purchase Price pursuant to this Section 3(c) by (y) the Purchase
Price in effect  immediately  after such  reduction  or increase in the Purchase
Price pursuant to this Section 3(c).

                  (d) In case the Company  shall on or after the Issuance  Date,
by dividend or  otherwise,  distribute to all holders of its Common Stock shares
of any class of  capital  stock of the  Company  (other  than any  dividends  or
distributions  to which Section 3(a) applies) or evidences of its  indebtedness,
cash or other assets (including securities, but excluding any rights or warrants
referred to in Section 3(b) and dividends and distributions  paid exclusively in
cash and excluding any capital stock, evidences of indebtedness,  cash or assets
distributed  upon a merger or  consolidation  to which  Section 4 applies)  (the
foregoing  hereinafter in this Section 3(d) called the "Securities")),  then, in
each such case, subject to the second paragraph of this Section 3(d):

                  (1) the Purchase Price shall be reduced so that the same shall
         be equal to the price  determined by multiplying  the Purchase Price in
         effect  immediately  prior to the close of  business on the Record Date
         with respect to such  distribution by a fraction of which the numerator
         shall be the  Current  Market  Price on such date less the fair  market
         value (as  determined  by the Board of Directors,  whose  determination
         shall be conclusive  and described in a Board  Resolution) on such date
         of the portion of the Securities so distributed applicable to one share
         of Common Stock and the denominator shall be such Current Market Price,
         such reduction to become effective  immediately prior to the opening of
         business on the day following such Record Date; provided, however, that
         in the event  the then fair  market  value  (as so  determined)  of the
         portion of the  Securities  so  distributed  applicable to one share of
         Common  Stock is equal to or greater  than the Current  Market Price on
         the  Record  Date,  in  lieu  of  the  foregoing  adjustment,  adequate
         provision  shall be made so that the  Holder  shall  have the  right to
         receive  upon  exercise of this  Warrant  (or any  portion  hereof) the
         amount of  Securities  the Holder  would have  received  had the Holder
         exercised this Warrant (or portion  hereof)  immediately  prior to such
         Record Date; and

                  (2) if the Purchase Price is reduced as provided in clause (1)
         of this  Section 3(d) the number of shares of Common Stock which may be
         purchased  upon  exercise of this Warrant  commencing at the opening of
         business on the day following  such Record Date shall be increased to a
         number  equal to the quotient  obtained by dividing  (x) the 

                                      C-55
<PAGE>

         Aggregate  Purchase Price in effect immediately prior to such reduction
         in the Purchase Price  pursuant to Section  3(d)(1) by (y) the Purchase
         Price in effect  immediately after such reduction in the Purchase Price
         pursuant to clause (1) of this Section 3(d).

In the event that such  dividend  or  distribution  is not so paid or made,  the
Purchase Price shall again be adjusted to be the Purchase Price which would then
be in effect if such  dividend or  distribution  had not been  declared  and the
number of shares of Common  Stock for  which  this  Warrant  may  thereafter  be
exercised shall again be adjusted  (subject to proportionate  adjustment for any
intervening  exercises  of this  Warrant)  to the number  which would then be in
effect if such dividend or distribution  had not been declared.  If the Board of
Directors  determines the fair market value of any  distribution for purposes of
this Section 3(d) by reference to the actual or when issued  trading  market for
any Securities comprising all or part of such distribution,  it must in doing so
consider  the prices in such market over the same period used in  computing  the
Current Market Price to the extent possible.

                  Rights or warrants  distributed  by the Company to all holders
of Common  Stock  entitling  the holders  thereof to  subscribe  for or purchase
shares  of the  Company's  capital  stock  (either  initially  or under  certain
circumstances),  which rights or warrants,  until the  occurrence of a specified
event or events (a "Trigger Event"):  (i) are deemed to be transferred with such
shares of Common Stock;  (ii) are not exercisable;  and (iii) are also issued in
respect of future  issuances of Common  Stock,  shall not be deemed to have been
distributed  for purposes of this Section 3 (and no  adjustment  to the Purchase
Price or the  number  of  shares of Common  Stock  which may be  purchased  upon
exercise  of this  Warrant  under  this  Section 3 will be  required)  until the
occurrence  of the  earliest  Trigger  Event.  If any such  rights or  warrants,
including any such existing rights or warrants distributed prior to the Issuance
Date  (including the Preferred  Share Purchase  Rights),  are subject to Trigger
Events,  upon the  satisfaction  of each of which such rights or warrants  shall
become exercisable to purchase different  securities,  evidences of indebtedness
or other assets,  then the occurrence of each such Trigger Event shall be deemed
to be such date of  issuance  and  Record  Date with  respect  to new  rights or
warrants  (and a termination  or  expiration of the existing  rights or warrants
without exercise by the holder thereof) (so that, by way of illustration and not
limitation,  the dates of issuance of any such rights  shall be deemed to be the
dates on which such rights become  exercisable to purchase  capital stock of the
Company,  and not the date on which such  rights  may be  issued,  or may become
evidenced by separate certificates, if such rights are not then so exercisable).
In addition,  in the event of any  distribution  of rights or  warrants,  or any
Trigger  Event with respect  thereto  (including  the Preferred  Share  Purchase
Rights),  that was counted for purposes of calculating a distribution amount for
which adjustments to the Purchase Price and the number of shares of Common Stock
for which this  Warrant may be  exercised  under this Section 3 were made (1) in
the case of any such  rights or warrants  which shall all have been  redeemed or
repurchased without exercise by any holders thereof, the Purchase Price shall be
readjusted  (and the number of shares of Common Stock for which this Warrant may
thereafter be exercised shall be readjusted, subject to proportionate adjustment
for any  intervening  exercises of this Warrant)  upon such final  redemption or
repurchase to give effect to such distribution or Trigger Event, as the case may
be, as though it were a cash distribution,  equal to the per share redemption or
repurchase price received by a holder or holders of Common Stock with respect to
such  rights or  warrants  (assuming  such  holder had  retained  such rights or
warrants), made to all holders of Common Stock as of the date of such redemption
or  repurchase,  and (2) in the case of such rights or warrants  (including  the
Preferred  Share  Purchase  Rights) which shall have expired or been  terminated
without exercise by any holders thereof,  the Purchase Price shall be readjusted
as if such rights and  warrants  had not been issued and the number of shares of
Common  Stock for which  this  Warrant  may  thereafter  be  exercised  shall be
readjusted (subject to proportionate 

                                      C-56
<PAGE>

adjustment for any intervening  exercises of this Warrant) as if such rights and
warrants had not been issued.

                  For purposes of this  Section 3(d) and Sections  3(a) and (b),
any dividend or  distribution to which this Section 3(d) is applicable that also
includes  shares of Common  Stock,  or rights or  warrants to  subscribe  for or
purchase  shares of Common Stock to which Section 3(b) applies (or both),  shall
be deemed  instead to be (1) a dividend  or  distribution  of the  evidences  of
indebtedness,  assets,  shares of capital  stock,  rights or warrants other than
such shares of Common Stock or rights or warrants to which  Section 3(b) applies
(and any Purchase Price reduction and increase in the number of shares of Common
Stock for which this Warrant may  thereafter  be exercised  that are required by
this Section 3(d) with respect to such  dividend or  distribution  shall then be
made)  immediately  followed by (2) a dividend or distribution of such shares of
Common  Stock or such  rights  or  warrants  (and  any  further  Purchase  Price
reduction  and  increase in the number of shares of Common  Stock for which this
Warrant may  thereafter be exercised  that are required by Sections 3(a) and (b)
with respect to such dividend or  distribution  shall then be made),  except (A)
the Record Date of such dividend or  distribution  shall be  substituted as "the
date fixed for the  determination  of  stockholders  entitled  to  receive  such
dividend or other distribution",  "Record Date fixed for such determination" and
"Record  Date" within the meaning of Section 3(a) and as "the date fixed for the
determination of stockholders entitled to receive such rights or warrants", "the
Record Date fixed for the determination of the stockholders  entitled to receive
such rights or  warrants"  and "such  Record Date" within the meaning of Section
3(b)  and  (B)  any  shares  of  Common  Stock  included  in  such  dividend  or
distribution  shall not be deemed  "outstanding  at the close of business on the
Record Date fixed for such determination" within the meaning of Section 3(a).

                  (e) In case the Company  shall on or after the Issuance  Date,
by dividend or  otherwise,  distribute  to all holders of its Common  Stock cash
(excluding any cash that is distributed  upon a merger or consolidation to which
Section 4 applies or as part of a  distribution  referred to in Section 3(d)) in
an aggregate  amount that,  combined with (1) the aggregate  amount of any other
such  distributions  to all holders of its Common Stock made exclusively in cash
within the 12 months preceding the date of payment of such distribution,  and in
respect of which no adjustment  pursuant to this Section 3(e) has been made, and
(2) the  aggregate of any cash plus the fair market value (as  determined by the
Board of Directors,  whose  determination shall be conclusive and set forth in a
Board Resolution) of consideration payable in respect of any Tender Offer by the
Company or any Subsidiary  for all or any portion of the Common Stock  concluded
within the 12 months preceding the date of payment of such distribution,  and in
respect of which no adjustment  pursuant to Section 3(f) has been made,  exceeds
10% of the  product of (x) the  Current  Market  Price on the  Record  Date with
respect  to such  distribution  times (y) the  number of shares of Common  Stock
outstanding  on such date,  then, and in each such case,  immediately  after the
close of business on such date,  unless the Company  elects to reserve such cash
for distribution to the Holder upon the exercise of this Warrant (and shall have
made adequate provision) so that the Holder will receive upon such exercise,  in
addition  to the  shares of Common  Stock to which the Holder is  entitled,  the
amount  of cash  which  the  Holder  would  have  received  if the  Holder  had,
immediately  prior to the Record Date for such  distribution of cash,  exercised
this Warrant to purchase Common Stock:

                  (1) the Purchase Price shall be reduced so that the same shall
         equal the price  determined by multiplying the Purchase Price in effect
         immediately  prior to the close of  business  on such  Record Date by a
         fraction  (i) the  numerator  of which  shall  be equal to the  Current
         Market Price on the Record Date less an amount equal to the quotient of
         (x) the excess of such combined amount over such 10% and (y) the number

                                      C-57
<PAGE>

         of shares of Common Stock  outstanding  on the Record Date and (ii) the
         denominator  of which shall be equal to the Current Market Price on the
         Record Date;  provided,  however,  that in the event the portion of the
         cash so distributed applicable to one share of Common Stock is equal to
         or greater  than the Current  Market  Price of the Common  Stock on the
         Record Date, in lieu of the foregoing  adjustment,  adequate  provision
         shall be made so that the Holder  shall have the right to receive  upon
         exercise of this Warrant (or any portion hereof) the amount of cash the
         Holder would have  received had the Holder  exercised  this Warrant (or
         portion hereof) immediately prior to such Record Date; and

                  (2) if the Purchase Price is reduced as provided in clause (1)
         of this  Section  3(e),  then the number of shares of Common  Stock for
         which this Warrant may  thereafter  be exercised  shall be increased at
         the time of such  reduction in the Purchase  Price to a number equal to
         the quotient  obtained by dividing (x) the Aggregate  Purchase Price in
         effect  immediately  prior to the close of business on such Record Date
         by (y) the Purchase Price in effect immediately after such reduction in
         the Purchase Price pursuant to clause (1) of this Section 3(e).

In the event that such  dividend  or  distribution  is not so paid or made,  the
Purchase Price shall again be adjusted to be the Purchase Price which would then
be in effect if such  dividend or  distribution  had not been  declared  and the
number of shares of Common  Stock for  which  this  Warrant  may  thereafter  be
exercised shall again be adjusted  (subject to proportionate  adjustment for any
intervening  exercises  of this  Warrant)  to the number  which would then be in
effect if such dividend or distribution had not been declared.

                  (f) In case a Tender Offer on or after the Issuance  Date made
by the  Company or any  Subsidiary  for all or any  portion of the Common  Stock
shall  expire and such Tender  Offer (as amended  upon the  expiration  thereof)
shall require the payment to  stockholders  (based on the  acceptance (up to any
maximum  specified  in the terms of the Tender  Offer) of  Purchased  Shares (as
defined  below)) of an  aggregate  consideration  having a fair market value (as
determined by the Board of Directors,  whose  determination  shall be conclusive
and  described  in a Board  Resolution)  that  combined  together  with  (1) the
aggregate of the cash plus the fair market value (as  determined by the Board of
Directors,  whose  determination  shall be  conclusive  and described in a Board
Resolution), as of the expiration of such Tender Offer, of consideration payable
in respect of any other Tender Offers,  by the Company or any Subsidiary for all
or any portion of the Common Stock expiring  within the 12 months  preceding the
expiration of such Tender Offer and in respect of which no  adjustment  pursuant
to  this  Section  3(f)  has  been  made  and (2) the  aggregate  amount  of any
distributions  to all holders of the Company's  Common Stock made exclusively in
cash within 12 months  preceding  the  expiration  of such  Tender  Offer and in
respect of which no adjustment  pursuant to Section 3(e) has been made,  exceeds
10% of the  product  of the  Current  Market  Price  as of the  last  time  (the
"Expiration  Time")  tenders  could have been made pursuant to such Tender Offer
(as it may be amended)  times the number of shares of Common  Stock  outstanding
(including any tendered  shares) at the Expiration  Time, then, and in each such
case,  immediately prior to the opening of business on the day after the date of
the Expiration Time:

                  (1) the  Purchase  Price  shall be  adjusted  so that the same
         shall equal the price  determined by multiplying  the Purchase Price in
         effect  immediately  prior  to  close  of  business  on the date of the
         Expiration  Time by a  fraction  of which  the  numerator  shall be the
         number of shares of Common Stock  outstanding  (including  any tendered
         shares) at the Expiration  Time  multiplied by the Current Market Price
         of the Common Stock on the 

                                      C-58
<PAGE>

         Trading Day next  succeeding  the Expiration  Time and the  denominator
         shall be the sum of (x) the fair market value (determined as aforesaid)
         of the aggregate  consideration  payable to  stockholders  based on the
         acceptance  (up to any  maximum  specified  in the terms of the  Tender
         Offer) of all  shares  validly  tendered  and not  withdrawn  as of the
         Expiration Time (the shares deemed so accepted, up to any such maximum,
         being referred to as the "Purchased Shares") and (y) the product of the
         number  of  shares  of Common  Stock  outstanding  (less any  Purchased
         Shares) on the  Expiration  Time and the  Current  Market  Price of the
         Common Stock on the Trading Day next  succeeding the  Expiration  Time;
         and

                  (2) the  number  of shares  of  Common  Stock  for which  this
         Warrant may  thereafter  be exercised  shall be adjusted at the time of
         such  reduction (if any) in the Purchase Price to a number equal to the
         quotient  obtained  by dividing  (x) the  Aggregate  Purchase  Price in
         effect  immediately  prior to the close of  business on the date of the
         Expiration Time by (y) the Purchase Price in effect  immediately  after
         such  reduction  in the Purchase  Price  pursuant to clause (1) of this
         Section 3(f).

Such  reduction  (if any) in the  Purchase  Price and  increase in the number of
shares of Common Stock for which the Warrant may  thereafter be exercised  shall
become  effective  immediately  prior  to the  opening  of  business  on the day
following  the  Expiration  Time.  In the event that the Company is obligated to
purchase  shares  pursuant  to  any  such  Tender  Offer,  but  the  Company  is
permanently prevented by applicable law from effecting any such purchases or all
such purchases are  rescinded,  the Purchase Price shall again be adjusted to be
the  Purchase  Price which would then be in effect if such Tender  Offer had not
been made.  If the  application  of this  Section 3(f) to any Tender Offer would
result in an increase in the Purchase  Price,  no  adjustment  shall be made for
such Tender Offer under this Section 3(f).

                  (g) (1) In case at any time on or after the Issuance  Date the
Company  shall  issue  shares of its Common  Stock or Common  Stock  Equivalents
(collectively,  the "Newly Issued  Shares"),  other than an issuance pro rata to
all holders of its  outstanding  Common Stock, at a price below the Current Fair
Market Value of the Common Stock at the time of such  issuance,  then  following
such  issuance of Newly  Issued  Shares the  Purchase  Price shall be reduced as
provided in clause (2) of this  Section  3(g) and the number of shares of Common
Stock which may be issued upon  exercise of this  Warrant  shall be increased as
provided in clause (3) of this Section 3(g).

                      (2) The reduction in the Purchase Price following any such
adjustment  shall be determined by multiplying  the Purchase  Price  immediately
prior to such adjustment by a fraction,  of which the numerator shall be the sum
of (a) the number of shares of Common Stock outstanding immediately prior to the
issuance  of the  Newly  Issued  Shares  (calculated  on a  fully-diluted  basis
assuming the exercise or conversion of all options, warrants, purchase rights or
convertible  securities  which are exercisable or convertible at the time of the
issuance  of the Newly  Issued  Shares)  plus (b) the number of shares of Common
Stock which the aggregate consideration, if any, received by the Company for the
number of Newly  Issued  Shares  would  purchase at a price equal to the Current
Fair  Market  Value of the Common  Stock at the time of such  issuance,  and the
denominator  shall  be the sum of (X) the  number  of  shares  of  Common  Stock
outstanding  immediately  prior  to the  issuance  of the  Newly  Issued  Shares
(calculated on a fully-diluted  basis assuming the exercise or conversion of all
options,   warrants,   purchase  rights  or  convertible  securities  which  are
exercisable  or  convertible  at the time of the  issuance  of the Newly  Issued
Shares) plus (Y) the number of Newly Issued Shares. The 

                                      C-59
<PAGE>

adjustment  provided  for  in  this  Section  3(g)(2)  may be  expressed  as the
following mathematical formula:

    ------------------------ ---------------------------------- -----------
                                      ( O +(C / FMV))              x PP
                                    -------------------
    ------------------------ ---------------------------------- -----------
                       NPP =             ( O + N )
    ------------------------ ---------------------------------- -----------
where,

         C   =  aggregate  consideration  received  by the Company for the Newly
                Issued Shares

         N   =  number of Newly Issued Shares

         O   =  number of shares of Common Stock outstanding (on a fully diluted
                basis, as described above)  immediately prior to the issuance of
                the Newly Issued Shares

         FMV =  Current  Fair  Market  Value of the Common  Stock at the time of
                issuance of the Newly Issued Shares

         PP  =  Purchase  Price  immediately  prior to the issuance of the Newly
                Issued Shares

         NPP =  Purchase  Price  immediately  after  the  issuance  of the Newly
                Issued Shares

                      (3) If the Purchase  Price is reduced in  connection  with
the issuance of Newly  Issued  Shares as provided in Section  3(g)(2),  then the
number of shares of Common  Stock for  which  this  Warrant  may  thereafter  be
exercised shall be increased at the time of such reduction in the Purchase Price
to a  number  equal to the  quotient  obtained  by  dividing  (x) the  Aggregate
Purchase  Price in effect  immediately  prior to such  issuance of Newly  Issued
Shares by (y) the Purchase  Price in effect  immediately  after such issuance of
Newly Issued  Shares after such  reduction  in the  Purchase  Price  pursuant to
Section 3(g)(2).

                      (4) Notwithstanding the foregoing,  no adjustment shall be
made under this Section 3(g) by reason of:

                                    (A) the issuance by the Company of shares of
Common  Stock pro rata to all  holders  of the  Common  Stock so long as (i) any
adjustment  required  by Section  3(a) is made and (ii) the  Company  shall have
given notice thereof to the Holder pursuant to Section 6;

                                    (B) the  issuance  by the  Company  of Newly
Issued  Shares in an offering  for cash for the  account of the Company  that is
underwritten on a firm commitment basis and is registered under the 1933 Act;

                                    (C) the  issuance by the Company for cash of
Newly Issued  Shares in  connection  with a strategic  alliance,  collaboration,
joint venture,  partnership  or similar  arrangement of the Company with another
Person which strategic alliance,  collaboration,  joint venture,  partnership or
similar arrangement  relates to the Company's business as conducted  immediately
prior  thereto and which  Person is engaged in a business  similar or related to
the  business of the Company so long as (x) the price per Newly  Issued Share is
not less than 85

                                      C-60
<PAGE>

percent of the  Current  Fair  Market  Value of the Common  Stock on the date of
issuance of such Newly Issued Shares and (y) the  consideration  other than cash
which  the  Company  receives  in  connection  with  such  strategic   alliance,
collaboration, joint venture, partnership or similar arrangement has a value, as
determined by the Board of Directors in its reasonable judgment and set forth in
a Board Resolution, at least equal to the amount by which (i) the product of the
number of Newly  Issued  Shares so issued times the Current Fair Market Value of
the Common  Stock on the date such Newly Issued  Shares are issued  exceeds (ii)
the aggregate cash  consideration  received by the Company for such Newly Issued
Shares at the time of issuance thereof;

                                    (D)  the  issuance  by  the  Company  of the
Warrant Notes or the Other Warrants or shares of Common Stock upon conversion of
the Notes or the Warrant  Notes or upon  exercise  of this  Warrant or the Other
Warrants in accordance with the terms hereof and thereof; and

                                    (E) the issuance by the Company of shares of
Common  Stock in  payment  of  interest  on the Notes and the  Warrant  Notes in
accordance with the terms thereof.

                  (h) The  Company  may make  such  reductions  in the  Purchase
Price,  in addition to those required by Sections 3(a), (b), (c), (d), (e), (f),
and (g),  as the  Board  of  Directors  considers  to be  advisable  to avoid or
diminish any income tax to holders of Common Stock or rights to purchase  Common
Stock resulting from any dividend or distribution of stock (or rights to acquire
stock) or from any event treated as such for income tax purposes.

                  (i) No  adjustment  in the  Purchase  Price  (and  no  related
adjustment  in the  number of shares of Common  Stock  which may  thereafter  be
purchased  upon  exercise  of  this  Warrant)  shall  be  required  unless  such
adjustment  would require an increase or decrease of at least 1% in the Purchase
Price;  provided,  however, that any adjustments which by reason of this Section
3(i) are not required to be made shall be carried forward and taken into account
in any subsequent  adjustment.  All  calculations  under this Section 3 shall be
made by the Company and shall be made to the nearest  cent or to the nearest one
hundredth of a share, as the case may be.

                  No  adjustment  need be made for a change  in the par value of
the  Common  Stock or from par value to no par value or from no par value to par
value.

                  (j)  Whenever  the  Purchase   Price  is  adjusted  as  herein
provided,  the  Company  shall  promptly,  but in no event  later than five days
thereafter,  give a notice to the Holder  setting  forth the Purchase  Price and
number of shares of Common  Stock which may be purchased  upon  exercise of this
Warrant after such  adjustment and setting forth a brief  statement of the facts
requiring such adjustment, but which statement shall not include any information
which would be material  non-public  information  for  purposes of the 1934 Act.
Failure to deliver  such notice shall not affect the legality or validity of any
such adjustment.

                  (k) In any case in  which  this  Section  3  provides  that an
adjustment shall become effective  immediately after a Record Date for an event,
the  Company  may defer  until the  occurrence  of such event (i) issuing to the
Holder in  connection  with any exercise of this Warrant  after such Record Date
and before the  occurrence of such event the  additional  shares of Common Stock
issuable upon such exercise by reason of the  adjustment  required by such event
over and above the Common Stock issuable upon such exercise before giving effect
to 

                                      C-61
<PAGE>

such  adjustment and (ii) paying to the Holder any amount in cash in lieu of any
fraction pursuant to Section 2.

                  (l) For  purposes  of this  Section 3, the number of shares of
Common  Stock at any time  outstanding  shall  not  include  shares  held in the
treasury of the Company but shall  include  shares  issuable in respect of scrip
certificates  issued in lieu of fractions of shares of Common Stock. The Company
will not pay any  dividend or make any  distribution  on shares of Common  Stock
held in the treasury of the Company  other than (i)  dividends or  distributions
payable only in shares of Common  Stock and (ii) the  Preferred  Share  Purchase
Rights.

         4. Effect of  Reclassification,  Consolidation,  Merger or Sale. (a) If
any of the following events occur, namely (i) any  reclassification or change of
the  outstanding  shares of Common Stock  (other than a change in par value,  or
from par  value to no par  value,  or from no par  value to par  value,  or as a
result of a  subdivision  or  combination),  (ii) any  consolidation,  merger or
combination of the Company with another corporation as a result of which holders
of Common Stock shall be entitled to receive stock, securities or other property
or assets (including cash) with respect to or in exchange for such Common Stock,
or (iii) any sale or conveyance of the  properties and assets of the Company as,
or substantially  as, an entirety to any other  corporation as a result of which
holders of Common Stock shall be entitled to receive stock,  securities or other
property or assets  (including  cash) with  respect to or in  exchange  for such
Common Stock,  then the Company or the successor or purchasing  corporation,  as
the case may be,  shall  execute with the Holder a written  agreement  providing
that this Warrant shall  thereafter  entitle the Holder to purchase the kind and
amount of shares of stock and other securities or property or assets  (including
cash)  receivable upon such  reclassification,  change,  consolidation,  merger,
combination,  sale or  conveyance  by the holder of a number of shares of Common
Stock issuable upon exercise of this Warrant  (assuming,  for such  purposes,  a
sufficient number of authorized shares of Common Stock available to convert this
Note) immediately prior to such reclassification, change, consolidation, merger,
combination,  sale or  conveyance  assuming  such holder of Common Stock did not
exercise such holder's  rights of election,  if any, as to the kind or amount of
securities,  cash or other property receivable upon such consolidation,  merger,
statutory exchange,  sale or conveyance (provided that, if the kind or amount of
securities,  cash or other property receivable upon such consolidation,  merger,
statutory exchange,  sale or conveyance is not the same for each share of Common
Stock in respect of which such rights of election  shall not have been exercised
("non-electing  share"),  then for the  purposes of this  Section 4 the kind and
amount of securities, cash or other property receivable upon such consolidation,
merger, statutory exchange, sale or conveyance for each non-electing share shall
be deemed to be the kind and amount so  receivable  per share by a plurality  of
the non-electing  shares).  Such written agreement shall provide for adjustments
which shall be as nearly  equivalent as may be  practicable  to the  adjustments
provided  for in this  Warrant.  If,  in the case of any such  reclassification,
change,  consolidation,  merger,  combination,  sale or conveyance, the stock or
other securities and assets receivable thereupon by a holder of shares of Common
Stock includes  shares of stock or other  securities and assets of a corporation
other than the successor or purchasing corporation,  as the case may be, in such
reclassification,   change,   consolidation,   merger,   combination,   sale  or
conveyance,  then such  written  agreement  shall also be executed by such other
corporation  and  shall  contain  such  additional  provisions  to  protect  the
interests  of the Holder as the Board of  Directors  shall  reasonably  consider
necessary by reason of the foregoing.

                  (b) The above  provisions  of this  Section 4 shall  similarly
apply  to  successive  reclassifications,   changes,  consolidations,   mergers,
combinations, sales and conveyances.

                                      C-62
<PAGE>

                  (c) If this  Section  4 applies  to any  event or  occurrence,
Section 3 shall not apply.

         5.  Further  Assurances.  The Company  will take all action that may be
necessary or appropriate in order that the Company may validly and legally issue
fully paid and  nonassessable  shares of stock,  free from all taxes,  liens and
charges with respect to the issue thereof, on the exercise of all or any portion
of this Warrant from time to time outstanding.

         6. Notice to Holder Prior to Certain  Actions.  In case on or after the
Issuance Date:

                  (a) the  Company  shall  declare  a  dividend  (or  any  other
distribution) on its Common Stock (other than in cash out of retained earnings);
or

                  (b) the Company shall authorize the granting to the holders of
its Common Stock of rights or warrants to subscribe for or purchase any share of
any class or any other rights or warrants; or

                  (c)   the   Board   of   Directors    shall    authorize   any
reclassification of the Common Stock (other than a subdivision or combination of
its outstanding  Common Stock, or a change in par value, or from par value to no
par value, or from no par value to par value), or any consolidation or merger or
other business  combination  transaction to which the Company is a party and for
which approval of any  stockholders  of the Company is required,  or the sale or
transfer of all or substantially all of the assets of the Company; or

                  (d)  there  shall be  pending  the  voluntary  or  involuntary
dissolution, liquidation or winding-up of the Company;

the Company  shall give the Holder,  as promptly as possible but in any event at
least ten Trading Days prior to the applicable  date  hereinafter  specified,  a
notice  stating (x) the date on which a record is to be taken for the purpose of
such dividend,  distribution or rights or warrants, or, if a record is not to be
taken, the date as of which the holders of Common Stock of record to be entitled
to such dividend,  distribution or rights are to be determined,  or (y) the date
on  which  such   reclassification,   consolidation,   merger,   other  business
combination transaction, sale, transfer, dissolution,  liquidation or winding-up
is  expected  to  become  effective  or  occur,  and the  date as of which it is
expected  that  holders  of Common  Stock of record  who  shall be  entitled  to
exchange their Common Stock for securities or other  property  deliverable  upon
such  reclassification,   consolidation,   merger,  other  business  combination
transaction,  sale,  transfer,  dissolution,  liquidation or winding-up shall be
determined.  Such  notice  shall not  include  any  information  which  would be
material  non-public  information for purposes of the 1934 Act.  Failure to give
such notice, or any defect therein, shall not affect the legality or validity of
such dividend,  distribution,  reclassification,  consolidation,  merger,  sale,
transfer, dissolution, liquidation or winding-up. In the case of any such action
of which the Company gives such notice to the Holder or is required to give such
notice to the Holder,  the Holder shall be entitled to give a subscription  form
to  exercise  this  Warrant  in  whole  or in  part  that is  contingent  on the
completion of such action.

         7. Reservation of Stock,  etc.,  Issuable on Exercise of Warrants.  The
Company will at all times reserve and keep  available out of its  authorized but
unissued  shares of capital  stock,  solely for  issuance  and  delivery  on the
exercise of this  Warrant,  a  sufficient  number of shares of Common  Stock (or
Other  Securities) to effect the full exercise of this Warrant and the

                                      C-63
<PAGE>

exercise, conversion or exchange of any other warrant or security of the Company
exercisable for,  convertible into,  exchangeable for or otherwise entitling the
holder to acquire  shares of Common Stock (or Other  Securities),  and if at any
time the number of  authorized  but  unissued  shares of Common  Stock (or Other
Securities)  shall not be  sufficient  to effect such  exercise,  conversion  or
exchange, the Company shall take such action as may be necessary to increase its
authorized  but unissued  shares of Common Stock (or Other  Securities)  to such
number as shall be sufficient for such purposes.

         8. Transfer of Warrant.  This Warrant shall inure to the benefit of the
successors to and assigns of the Holder.  This Warrant and all rights hereunder,
in whole or in part,  are  registrable  at the  office or agency of the  Company
referred  to below by the Holder in person or by his duly  authorized  attorney,
upon surrender of this Warrant properly endorsed.

         9. Register of Warrants.  The Company shall maintain,  at the principal
office of the Company (or such other office as it may designate by notice to the
Holder),  a register in which the Company  shall  record the name and address of
the Person in whose name this Warrant has been  issued,  as well as the name and
address of each successor and prior owner of such Warrant.  The Company shall be
entitled to treat the Person in whose name this Warrant is so  registered as the
sole and absolute owner of this Warrant for all purposes.

         10.  Exchange  of  Warrant.  This  Warrant  is  exchangeable,  upon the
surrender  hereof by the Holder at the office or agency of the Company  referred
to in Section 9, for one or more new Warrants of like tenor  representing in the
aggregate the right to subscribe for and purchase the number of shares of Common
Stock (or other securities) which may be subscribed for and purchased hereunder,
each of such new Warrants to represent  the right to subscribe  for and purchase
such number of shares as shall be  designated  by the Holder at the time of such
surrender.

         11.  Replacement  of  Warrant.  On receipt by the  Company of  evidence
reasonably  satisfactory  to it  of  the  ownership  of  and  the  loss,  theft,
destruction or mutilation of this Warrant and (a) in the case of loss,  theft or
destruction, of indemnity from the Holder reasonably satisfactory in form to the
Company (and without the requirement to post any bond or other security), or (b)
in the case of mutilation,  upon surrender and cancellation of this Warrant, the
Company will  execute and deliver to the Holder a new Warrant of like tenor.  In
connection  with the issuance of any such new  Warrant,  the Holder shall pay or
reimburse the Company for the  reasonable  and  documented  attorneys'  fees and
expenses  incurred by the Company in connection  therewith (but not in excess of
$500.00 for each such issuance).

         12.  Warrant  Agent.  The Company may, by written notice to the Holder,
appoint the transfer  agent and  registrar for the Common Stock as the Company's
agent for the  purpose  of issuing  Common  Stock (or Other  Securities)  on the
exercise of this Warrant  pursuant to Section 1, and the Company may, by written
notice to the Holder,  appoint an agent having an office in the United States of
America for the purpose of exchanging  this Warrant  pursuant to Section 10, and
replacing  this  Warrant  pursuant to Section 11, or any of the  foregoing,  and
thereafter any such exchange or  replacement,  as the case may be, shall be made
at such office by such agent.

         13.  Remedies.  The Company  stipulates that the remedies at law of the
Holder in the event of any default or  threatened  default by the Company in the
performance  of or compliance  with any of the terms of this Warrant are not and
will not be  adequate,  and that such terms may

                                      C-64
<PAGE>

be  specifically  enforced  by a  decree  for the  specific  performance  of any
agreement contained herein or by an injunction against a violation of any of the
terms hereof or otherwise.

         14. No Rights or Liabilities  as a Stockholder.  This Warrant shall not
entitle the Holder to any voting rights or other rights as a stockholder  of the
Company. Nothing contained in this Warrant shall be construed as conferring upon
Holder  hereof  the  right  to vote or to  consent  or to  receive  notice  as a
stockholder  of the  Company  on any  matters  or  with  respect  to any  rights
whatsoever as a stockholder  of the Company.  No dividends or interest  shall be
payable or accrued in respect of this Warrant or the interest represented hereby
or the Common Stock  purchasable  hereunder  until, and only to the extent that,
this Warrant shall have been exercised in accordance with its terms.

         15. Notices, etc. All notices and other communications from the Company
to the Holder shall be mailed by first class certified mail, postage prepaid, at
such address as may have been  furnished to the Company in writing by the Holder
or at the address  shown for the Holder on the register of Warrants  referred to
in Section 9.

         16. Transfer  Restrictions.  This Warrant has not been and is not being
registered under the provisions of the 1933 Act or any state securities laws and
this Warrant may not be transferred  unless (1) the transferee is an "accredited
investor" (as defined in Regulation D under the 1933 Act) or a QIB in a transfer
that meets the requirements of Rule 144A and (2) the Holder shall have delivered
to the Company an opinion of counsel, reasonably satisfactory in form, scope and
substance  to the  Company,  to the  effect  that  this  Warrant  may be sold or
transferred without registration under the 1933 Act. Prior to any such transfer,
such  transferee  shall have  represented  in writing to the  Company  that such
transferee has requested and received from the Company all information  relating
to the business, properties, operations, condition (financial or other), results
of operations or prospects of the Company  deemed  relevant by such  transferee;
that such  transferee has been afforded the  opportunity to ask questions of the
Company  concerning  the  foregoing  and has had the  opportunity  to obtain and
review the Registration  Statement and the prospectus included therein,  each as
amended or  supplemented  to the date of  transfer to such  transferee,  and the
reports and other  information  concerning the Company which at the time of such
transfer  have been filed by the Company  with the SEC  pursuant to the 1934 Act
and which are  incorporated  by reference in such  prospectus  as of the date of
such transfer. If such transfer is intended to assign the rights and obligations
under  Sections  5, 8, 9,  and 10 of the  Securities  Purchase  Agreement,  such
transfer  shall  otherwise  be made in  compliance  with  Section  10(j)  of the
Securities Purchase Agreement.

         17. Rule 144A Information  Requirement.  Within the period prior to the
expiration  of the holding  period  applicable to sales hereof under Rule 144(k)
under the 1933 Act (or any  successor  provision),  the  Company  covenants  and
agrees that it shall, during any period in which it is not subject to Section 13
or 15(d) under the 1934 Act, make  available to the Holder and the holder of any
Common  Stock  issued  upon  exercise  of  this  Warrant  which  continue  to be
Restricted  Securities in connection  with any sale thereof and any  prospective
purchaser of this Warrant from the Holder, the information  required pursuant to
Rule  144A(d)(4)  under the 1933 Act upon the  request of the Holder and it will
take such further action as the Holder may reasonably request, all to the extent
required  from time to time to enable  the Holder to sell this  Warrant  without
registration  under the 1933 Act within the limitation of the exemption provided
by Rule 144A, as Rule 144A may be amended from time to time. Upon the request of
the Holder,  the Company  will  deliver to the Holder a written  statement as to
whether it has complied with such requirements.

                                      C-65
<PAGE>

         18.  Legend.  Unless  theretofore  registered for resale under the 1933
Act, each certificate for shares issued upon exercise of this Warrant shall bear
the following  legend:  The securities  represented by this certificate have not
been  registered  under the Securities  Act of 1933, as amended.  The securities
have been acquired for investment and may not be resold, transferred or assigned
in the absence of an effective  registration  statement for the securities under
the  Securities  Act of 1933,  as amended,  or an opinion of counsel  reasonably
satisfactory  in form,  scope and substance to the Company that  registration is
not required under said Act.

         19.  Miscellaneous.  This  Warrant and any terms hereof may be changed,
waived,  discharged or terminated only by an instrument in writing signed by the
party against whom enforcement of such change, waiver,  discharge or termination
is sought.  This Warrant shall be construed and enforced in accordance  with and
governed by the internal laws of the State of  California.  The headings in this
Warrant are for  purposes of  reference  only,  and shall not limit or otherwise
affect  any of the terms  hereof.  The  invalidity  or  unenforceability  of any
provision  hereof shall in no way affect the validity or  enforceability  of any
other provision.

         20. Attorneys' Fees. In any litigation, arbitration or court proceeding
between the Company and Holder relating  hereto,  the prevailing  party shall be
entitled to attorneys'  fees and expenses and all costs of proceedings  incurred
in enforcing this Warrant.

                                      C-66
<PAGE>

                  IN WITNESS WHEREOF,  the Company has caused this Warrant to be
executed on its behalf by one of its officers thereunto duly authorized.

Dated: ________________           SUGEN, INC.



                                  By:___________________________________________
                                     Name:
                                     Title:





                                      C-67
<PAGE>

                              FORM OF SUBSCRIPTION

                                   SUGEN, INC.

                   (To be signed only on exercise of Warrant)

TO:      SUGEN, Inc.
         230 East Grand Avenue
         South San Francisco, California   94080
         Attention:  Senior Vice President and Chief Financial Officer

         1. The undersigned  Holder of the attached  original,  executed Warrant
hereby elects to exercise its purchase  right under such Warrant with respect to
______________ shares (the "Exercise Shares") of Common Stock, as defined in the
Warrant, of SUGEN, Inc., a Delaware corporation (the "Company").

         2. The undersigned Holder (check one):

         [ ]      (a) elects to pay the aggregate purchase price for such shares
                  of Common Stock (i) in lawful money of the United States or by
                  the  enclosed  certified  or  official  bank check  payable in
                  United  States  dollars  to the  order of the  Company  in the
                  amount of  $___________,  or (ii) by wire  transfer  of United
                  States  funds to the  account of the  Company in the amount of
                  $____________,   which   transfer  has  been  made  before  or
                  simultaneously  with the delivery of this Form of Subscription
                  pursuant to the instructions of the Company;

                  or

         [ ]      (b) elects to receive  shares of Common  Stock  having a value
                  equal to the value of the  Warrant  calculated  in  accordance
                  with Section 1.2 of the Warrant.

         3. Please issue a stock  certificate or certificates  representing  the
appropriate  number of shares of Common Stock in the name of the  undersigned or
in such other names as is specified below:

         Name:    ___________________________________________

         Address: ___________________________________________

                  ___________________________________________

Dated:____________ ___, ____
                                    ____________________________________________
                                    (Signature must conform to name of Holder as
                                    specified on the face of the Warrant)

                                    ____________________________________________

                                    ____________________________________________
                                                    (Address)



                                      S-68
<PAGE>

                                                                       EXHIBIT D
                                                                         TO NOTE

                                 COMPANY NOTICE
            (Section 5.2(a) of 12% Senior Convertible Note due 2002)

TO:_______________________________________________________
                     (Name of Holder)

         1. A Repurchase Event described in the 12% Senior  Convertible Note due
2002 (the  "Note") of SUGEN,  Inc.,  a  Delaware  corporation  (the  "Company"),
occurred on ___________, _____. As a result of such Repurchase Event, the Holder
is entitled to exercise  its  repurchase  rights  pursuant to Section 5.2 of the
Note.

         2.  The  Holder's  repurchase  right  must be  exercised  on or  before
___________, _____.

         3. At or before the date set forth in the preceding  paragraph (2), the
Holder must:

                  (a)  deliver  to the  Company  a  Holder  Notice,  in the form
attached as Exhibit E to the Note; and

                  (b) the Note, duly endorsed for transfer to the Company of the
portion of the principal amount to be repurchased.

         4. Capitalized  terms used herein and not otherwise defined herein have
the respective meanings provided in the Note.

Date_________________________________   SUGEN, INC.



                                        By:_____________________________________

                                        Title:__________________________________



                                      D-69
<PAGE>

                                                                       EXHIBIT E
                                                                         TO NOTE

                                  HOLDER NOTICE
            (Section 5.2(b) of 12% Senior Convertible Note due 2002)

TO:      SUGEN, INC.

         1.  Pursuant to the terms of the 12% Senior  Convertible  Note due 2002
(the  "Note"),  the  undersigned  Holder  hereby elects to exercise its right to
require  repurchase  by the Company  pursuant  to Sections  5.2(a) and 5.2(b) of
$_______________  of the Note,  equal to the sum of  $_______________  principal
amount of the Note,  $_______________  of accrued  and unpaid  interest  on such
principal  amount and  $_______________  of Default Interest on such interest at
the Repurchase Price provided in the Note.

         2. Capitalized  terms used herein and not otherwise defined herein have
the respective meanings provided in the Note.

Date:________________________________   NAME OF HOLDER:

                                        ________________________________________



                                        By______________________________________
                                             Signature of Registered Holder
                                            (Must be signed exactly as name
                                                  appears in the Note.)



                                      E-70
<PAGE>

                                                                       EXHIBIT F
                                                                         TO NOTE

                      HOLDER REGISTRATION REPURCHASE NOTICE
              (Section 5.3 of 12% Senior Convertible Note due 2002)

TO:      SUGEN, INC.

         1.  Pursuant to the terms of the 12% Senior  Convertible  Note due 2002
(the  "Note"),  the  undersigned  Holder  hereby elects to exercise its right to
require repurchase by the Company pursuant to Section 5.3 of $_______________ of
the Note,  equal to the sum of  $_______________  principal  amount of the Note,
$_______________  of accrued and unpaid  interest on such  principal  amount and
$_______________  of  Default  Interest  on such  interest  at the  Registration
Repurchase Price provided in the Note.

         2. Capitalized  terms used herein and not otherwise defined herein have
the respective meanings provided in the Note.

Date:________________________________    NAME OF HOLDER:

                                         _______________________________________





                                         By_____________________________________
                                              Signature of Registered Holder
                                             (Must be signed exactly as name
                                                   appears in the Note.)



                                      F-71
<PAGE>

                                                                       Exhibit G
                                                                          to
                                                                         Note

                          SUBORDINATION OF INDEBTEDNESS

                  Any  Indebtedness  to be issued as  permitted by clause (5) of
the definition of Permitted Indebtedness in the Note shall contain the following
provisions and no provision inconsistent with the following provisions:

                           ARTICLE ____. SUBORDINATION

                  Section  __.1.   Agreement  of   Subordination.   The  Company
covenants  and  agrees,  and each  holder of the  indebtedness  created  by this
instrument (this  "Indebtedness")  by its acceptance hereof or thereof covenants
and agrees,  expressly for the benefit of holders of Senior  Indebtedness,  that
this Indebtedness shall be issued subject to the provisions of this Article; and
each person  holding  this  Indebtedness,  whether upon  original  issue or upon
transfer, assignment or exchange thereof, accepts and agrees to be bound by such
provisions.

                  The payment of the principal of, premium, if any, and interest
on this  Indebtedness  (including,  without  limitation,  upon any redemption or
repurchase  of  this  Indebtedness)  shall,  to the  extent  and  in the  manner
hereinafter set forth,  be  subordinated  and subject in right of payment to the
prior  payment  in full of all  Senior  Indebtedness  in cash or  other  payment
satisfactory to the holders of such Senior Indebtedness.

                  No provision of this Article shall  prevent the  occurrence of
any default or event of default with respect to this Indebtedness.

                  Section __.2. Payments to Holders of this Indebtedness. (a)(1)
No payment shall be made with respect to the principal of,  premium,  if any, or
interest on this Indebtedness  (including,  without  limitation,  the redemption
price with respect to any of this  Indebtedness  to be called for  redemption in
accordance with its terms or any repurchase of this Indebtedness) if:

                  (i) a default in the payment of  principal,  premium,  if any,
         interest  or other  obligations  in respect of the Senior  Indebtedness
         occurs and is continuing (a "Payment  Default"),  unless and until such
         Payment Default shall have been cured or waived or shall have ceased to
         exist; or

                  (ii) a default,  other than a Payment  Default,  on any Senior
         Indebtedness occurs and is continuing that then permits holders of such
         Senior  Indebtedness  to accelerate its maturity and the holder of this
         Indebtedness  (or indenture  trustee or other  representative  thereof)
         receives a notice of the default (a "Payment  Blockage  Notice") from a
         holder of Senior  Indebtedness,  a representative of the holder of such
         Senior Indebtedness or the Company (a "Non-Payment Default").

If the holder of this  Indebtedness  (or  indenture  trustee  or  representative
thereof)  receives  any Payment  Blockage  Notice  pursuant  to the  immediately
preceding clause (ii), no subsequent  Payment Blockage Notice shall be effective
for  purposes of this  Section __.2 unless and until (A) at least 365 days shall
have elapsed since the initial  effectiveness  of the immediately  prior Payment
Blockage Notice and (B) all scheduled  payments of principal,  premium,  if any,
and

                                      G-72
<PAGE>

interest on this Indebtedness that have become due and are required by the terms
of this  Indebtedness  to be paid in cash  have  been  paid in full in cash.  No
Non-Payment  Default that existed or was  continuing  on the date of delivery of
any Payment  Blockage  Notice to the holder of this  Indebtedness  (or indenture
trustee or other  representative  thereof) shall be, or be made, the basis for a
subsequent  Payment  Blockage Notice,  unless such Non-Payment  Default is based
upon facts or events arising after the date of delivery of such Payment Blockage
Notice.

                  (2)  The  Company  may  and  shall  resume   payments  on  and
distributions in respect of this Indebtedness upon:

                  (A) in the case of a Payment Default,  the date upon which any
         such Payment Default is cured or waived or ceases to exist, or

                  (B) in the case of a Non-Payment  Default,  the earlier of (a)
         the date upon which such  default is cured or waived or ceases to exist
         or (b) 179  days  after  the  applicable  Payment  Blockage  Notice  is
         received by the holder of this  Indebtedness  (or indenture  trustee or
         other   representative   thereof)  if  the   maturity  of  such  Senior
         Indebtedness  has not been  accelerated  and no  Payment  Default  with
         respect  to any Senior  Indebtedness  has  occurred  which has not been
         cured or waived (in which case clause (A) shall be applicable),

unless this Article __ otherwise  prohibits the payment or  distribution  at the
time of such payment or distribution.

                  (b) A "Reorganization" shall include and mean any dissolution,
winding up, total or partial  liquidation or reorganization  of the Company,  or
any  similar  transaction  resulting  in any  payment or  distribution  of cash,
securities or other property  ("Distributions") to creditors,  whether voluntary
or involuntary or in bankruptcy, insolvency, receivership or other proceedings.

                  (c) Upon any Reorganization,  all amounts due or to become due
upon  all  Senior  Indebtedness  shall  first  be paid in full in cash or  other
payment  satisfactory  to the  holders of such Senior  Indebtedness,  or payment
thereof  provided for in cash or other  payment  satisfactory  to the holders of
such Senior Indebtedness, before any Distribution is made to, for, or on account
of this Indebtedness or any portion thereof (including,  without limitation, any
Distribution in connection  with a payment of principal,  interest or premium or
the redemption or repurchase of all or any portion of this Indebtedness).

                  (d) Upon any  Reorganization,  all Distributions on account of
this  Indebtedness  shall be made by the Company or by any receiver,  trustee in
bankruptcy, liquidating trustee, agent, assignee for the benefit of creditors or
other  person  making  such  Distribution  directly  to the  holders  of  Senior
Indebtedness (pro rata to such holders on the basis of the respective amounts of
Senior  Indebtedness held by such holders,  or as otherwise required by law or a
court  order or the terms of any  subordination  as between or among such Senior
Indebtedness) or their respective  representative or  representatives,  as their
respective  interests  may  appear,  to the extent  necessary  to pay all Senior
Indebtedness  in full in cash or other  payment  satisfactory  to the holders of
such Senior  Indebtedness,  after  giving  effect to any  concurrent  payment or
distribution  to  or  for  the  holders  of  Senior  Indebtedness,   before  any
Distribution is made on account of this Indebtedness.

                  (e)  In the  event  that,  notwithstanding  the  foregoing,  a
Distribution on account of this Indebtedness is received by a holder thereof (or
indenture trustee or other representative

                                      G-73
<PAGE>

thereof) from the Company (including,  without limitation, by way of set-off) or
from the holder (or indenture  trustee or other  representative  thereof) of any
indebtedness subordinated to this Indebtedness,  such Distribution shall be held
by the recipient or recipients thereof in trust for the benefit of, and shall be
paid  over or  delivered  to,  the  holders  of  Senior  Indebtedness,  or their
respective representative or representatives,  in the same manner and fashion as
the Company is obligated to make the same under paragraphs (d) and (e) above.

                  (f) In the event  that,  notwithstanding  the  foregoing,  any
payment  or  distribution  of assets of the  Company  of any kind or  character,
whether in cash, property or securities (including,  without limitation,  by way
of set-off or otherwise),  prohibited by the foregoing, shall be received by any
holder  of this  Indebtedness  (or  indenture  trustee  or other  representative
thereof) before all Senior Indebtedness is paid in full in cash or other payment
satisfactory  to the holders of such Senior  Indebtedness,  or provision is made
for  such  payment  in  accordance  with  its  terms  in cash or  other  payment
satisfactory  to the  holders  of such  Senior  Indebtedness,  such  payment  or
distribution  shall be held by the  recipient  or  recipients  in trust  for the
benefit  of,  and shall be paid over or  delivered  to,  the  holders  of Senior
Indebtedness or their respective  representative  or  representatives,  as their
respective  interests may appear, as calculated by the Company,  for application
to the  payment  of all  Senior  Indebtedness  remaining  unpaid  to the  extent
necessary  to pay all  Senior  Indebtedness  in full  in cash or  other  payment
satisfactory to the holders of such Senior Indebtedness,  after giving effect to
any concurrent  payment or  distribution  (or provision  therefor) to or for the
holders of such Senior Indebtedness.

                  (g) In the  event  of the  acceleration  of this  Indebtedness
because of an event of default or any amount of  principal of or premium on this
Indebtedness  becomes due prior to the maturity  date of this  Indebtedness,  no
payment  or  distribution  shall be made any  holder  of this  Indebtedness  (or
indenture trustee or other  representative  thereof) in respect of the principal
of,  premium,  if any,  or  interest on this  Indebtedness  (including,  without
limitation,  any  redemption  or  repurchase  price of any of this  Indebtedness
called for  redemption in accordance  with its terms or submitted for redemption
or  repurchase  at the option of the holder of this  Indebtedness  in accordance
with its terms, as the case may be), until all Senior Indebtedness has been paid
in full in cash or other  payment  satisfactory  to the  holders of such  Senior
Indebtedness  or such  acceleration is rescinded in accordance with the terms of
this Indebtedness.  If payment of this Indebtedness is accelerated because of an
event of default,  the Company,  the holder of this  Indebtedness  (or indenture
trustee or other  representative  thereof) shall promptly  notify holders of the
Senior Indebtedness of such acceleration.

                  (h) Except as shall be specifically prohibited by this Section
_.2, nothing contained in this Article shall prevent the Company from making any
scheduled payment of principal or interest on this Indebtedness.

                  Section __.3. Subrogation of this Indebtedness. Subject to the
payment in full of all Senior Indebtedness in cash or other payment satisfactory
to the  holders of such Senior  Indebtedness,  the rights of the holders of this
Indebtedness  shall be subrogated to the extent of the payments or distributions
made to the holders of such Senior  Indebtedness  pursuant to the  provisions of
this Article  (equally and ratably with the holders of all  indebtedness  of the
Company which by its express terms is  subordinated  to Senior  Indebtedness  to
substantially  the same  extent  as this  Indebtedness  is  subordinated  and is
entitled to like rights of  subrogation)  to the rights of the holders of Senior
Indebtedness  to  receive  payments  or  distributions  of  cash,   property  or
securities  of the  Company  applicable  to the  Senior  Indebtedness  until the
principal of (and premium,  if any) and interest on this  Indebtedness  shall be
paid in  full;  and,  for the  purposes  of such  subrogation,  no  payments  or
distributions to the holders of the Senior

                                      G-74
<PAGE>

Indebtedness  of any cash,  property or  securities to which the holders of this
Indebtedness would be entitled except for the provisions of this Article, and no
payment over pursuant to the  provisions of this Article,  to or for the benefit
of the  holders  of Senior  Indebtedness  by holders  of this  Indebtedness  (or
indenture trustee or other representative thereof), shall, as among the Company,
its creditors other than holders of Senior Indebtedness, and the holders of this
Indebtedness,  be deemed to be a payment by the  Company to or on account of the
Senior  Indebtedness;  and no payments  or  distributions  of cash,  property or
securities to or for the benefit of the holders of this Indebtedness pursuant to
the subrogation provisions of this Article, which would otherwise have been paid
to the  holders of Senior  Indebtedness,  shall be deemed to be a payment by the
Company to or for the account of this Indebtedness.

                  Section __.4.  Provisions Solely to Define Relative Rights. It
is understood  that the  provisions of this Article are and are intended  solely
for the  purposes  of  defining  the  relative  rights  of the  holders  of this
Indebtedness,  on the one hand, and the holders of the Senior  Indebtedness,  on
the  other  hand.  Nothing  contained  in this  Article  or in the terms of this
Indebtedness is intended to or shall impair, as among the Company, its creditors
other  than  the  holders  of  Senior  Indebtedness,  and  the  holders  of this
Indebtedness,   the   obligation   of  the   Company,   which  is  absolute  and
unconditional,  to pay to the holders of this Indebtedness the principal of (and
premium,  if any) and interest on this  Indebtedness  as and when the same shall
become due and payable in accordance  with its terms, or is intended to or shall
affect the relative rights of the holders of this  Indebtedness and creditors of
the  Company  other  than the  holders  of the  Senior  Indebtedness,  nor shall
anything  herein  or  therein  prevent  any  holder  of this  Indebtedness  from
exercising all remedies otherwise permitted by applicable law upon default under
this  Indebtedness,  subject to the rights,  if any,  under this  Article of the
holders of Senior Indebtedness in respect of cash, property or securities of the
Company received upon the exercise of any such remedy.

                  Section __.5.  Reliance on Judicial  Order or  Certificate  of
Liquidating  Agent.  Upon any payment or  distribution  of assets of the Company
referred to in this Article,  the holders of this Indebtedness shall be entitled
to rely upon any order or decree made by any court of competent  jurisdiction in
which  such  insolvency,  bankruptcy,  receivership,   dissolution,  winding-up,
liquidation,  reorganization  or similar  case or  proceeding  is pending,  or a
certificate  of  the  receiver,  trustee  in  bankruptcy,  liquidating  trustee,
custodian,  agent, assignee for the benefit of creditors, or other person making
such payment or distribution,  delivered to the holders of this Indebtedness (or
indenture  trustee  or  other  representative   thereof),  for  the  purpose  of
ascertaining  the persons  entitled to  participate  in such  distribution,  the
holders of the Senior  Indebtedness and other  indebtedness of the Company,  the
amount  thereof or payable  thereon,  the amount or amounts paid or  distributed
thereon and all other facts pertinent thereto or to this Article.

                  Section __.6. No Impairment of Subordination.  No right of any
present or future holder of any Senior Indebtedness to enforce  subordination as
herein  provided  shall at any time in any way be  prejudiced or impaired by any
act or  failure  to act on the part of the  Company  or by any act or failure to
act, in good faith, by any such holder,  or by any  noncompliance by the Company
with  the  terms,  provisions  and  covenants  of the  Notes  or the  documents,
agreements and instruments relating thereto or to this Indebtedness,  regardless
of any knowledge  thereof which any such holder may have or otherwise be charged
with.

                  Section __.7.  Certain  Conversions  Deemed  Payment.  If this
Indebtedness is convertible into securities of the Company,  for the purposes of
this Article  only,  (1) the issuance  and  delivery of junior  securities  upon
conversion of this  Indebtedness in accordance with such 

                                      G-75
<PAGE>

conversion rights shall not be deemed to constitute a payment or distribution on
account  of  the  principal  of  (or  premium,  if  any)  or  interest  on  this
Indebtedness  or on  account  of the  purchase  or  other  acquisition  of  this
Indebtedness,  and (2) the  payment,  issuance or delivery of cash,  property or
securities  (other than junior  securities) upon conversion of this Indebtedness
shall be deemed to  constitute  payment  on  account  of the  principal  of (and
premium,  if any) and  interest on this  Indebtedness.  For the purposes of this
Section, the term "junior securities" means (a) shares of any stock of any class
of the Company,  (b) securities of the Company that are subordinated in right of
payment to all Senior  Indebtedness to substantially the same extent as, or to a
greater extent than,  this  Indebtedness  is so subordinated as provided in this
Article  and (c)  securities,  if any,  into  which  this  Indebtedness  becomes
convertible  in  connection  with any  business  combination  transaction  if so
provided in the terms of this Indebtedness. Nothing contained in this Article or
elsewhere in the terms of this  Indebtedness is intended to or shall impair,  as
among the Company,  its creditors other than holders of Senior  Indebtedness and
the holders of this  Indebtedness,  the right,  if any,  which is  absolute  and
unconditional,  of the  holder  of this  Indebtedness,  if by the  terms of this
Indebtedness this Indebtedness is convertible into securities of the Company, to
convert this Indebtedness in accordance with the terms of this Indebtedness.

                  Section __.8 Senior Indebtedness Entitled to Rely. The holders
of Senior  Indebtedness  shall have the right to rely upon this Article,  and no
amendment or modification of the provisions  contained herein shall diminish the
rights of such holders unless such holders shall have agreed in writing thereto.

                  Section  __.9  Definitions.  As  used  in  this  Article,  the
following terms shall have the following meanings:

                  Company:  The term  "Company"  means  SUGEN,  Inc., a Delaware
corporation, and shall include its successors and assigns.

                  Notes: The term "Notes" means the 12% Senior Convertible Notes
due 2002 at any one time  outstanding  not in excess of the  original  aggregate
authorized  amount  of  $40,000,000,  issued  by  the  Company  pursuant  to the
Securities  Purchase  Agreements  and the 12%  Senior  Convertible  Notes of the
Company in the original  aggregate  principal amount at any one time outstanding
not in excess of $30,000,000 that are issued or issuable by the Company pursuant
to the 12% Senior  Convertible  Note  Purchase  Warrants  issued by the  Company
pursuant to such Securities Purchase Agreements, including any such notes issued
upon  transfer  thereof  or in  lieu  of any  such  notes  that  are  mutilated,
destroyed, lost or stolen.

                  Securities Purchase Agreements:  The term "Securities Purchase
Agreements" means the several Securities Purchase and Exchange Agreements, dated
as of March 19,  1999,  by and between the Company and the several  buyers named
therein, as amended from time to time.

                  Senior Indebtedness:  The term "Senior Indebtedness" means the
principal of, premium,  if any, and interest on (including any interest accruing
after the filing of a petition by or against the  Company  under any  bankruptcy
law, whether or not allowed as a claim after such filing in any proceeding under
such bankruptcy law), and any other payment (including,  without limitation, the
Optional  Redemption  Consideration  (as defined in the Notes),  the  Repurchase
Price (as  defined  in the  Notes)  and the  Registration  Repurchase  Price (as
defined  in  the  Notes))  due  pursuant  to,  any  of  the  following,  whether
outstanding at the time of issuance of this Indebtedness or thereafter  incurred
or created:

                                      G-76
<PAGE>

                  (a) the Notes; and

                  (b)   all   renewals,   extensions,   refundings,   deferrals,
amendments or modifications of the Notes;

unless  in the  case  of any  such  renewal,  extension,  refunding,  amendment,
modification  or  supplement,  the  instrument  or other  document  creating  or
evidencing  the  same or the  assumption  or  guarantee  of the  same  expressly
provides that such renewal,  extension,  refunding,  amendment,  modification or
supplement  is not superior in right of payment to, or is pari passu with,  this
Indebtedness.


                                      G-77


THIS  WARRANT  HAS NOT BEEN  REGISTERED  UNDER THE  SECURITIES  ACT OF 1933,  AS
AMENDED (THE "1933 ACT"),  OR APPLICABLE  STATE  SECURITIES  LAWS AND MAY NOT BE
SOLD,  TRANSFERRED OR ASSIGNED UNLESS (1) THE RESALE HEREOF IS REGISTERED  UNDER
THE 1933 ACT,  (2) THE  COMPANY HAS  RECEIVED  AN OPINION OF COUNSEL  REASONABLY
SATISFACTORY IN FORM, SCOPE AND SUBSTANCE TO THE COMPANY THAT SUCH  REGISTRATION
IS NOT REQUIRED OR (3) SOLD,  TRANSFERRED  OR ASSIGNED TO A QIB PURSUANT TO RULE
144A.

THIS WARRANT IS ISSUED PURSUANT TO A SECURITIES PURCHASE AND EXCHANGE AGREEMENT,
DATED AS OF MARCH 19, 1999,  BY AND BETWEEN THE COMPANY AND THE ORIGINAL  HOLDER
OF THIS  WARRANT,  AS AMENDED FROM TIME TO TIME,  AND THE HOLDER OF THIS WARRANT
AND THIS WARRANT ARE SUBJECT TO CERTAIN OF THE TERMS OF THE SECURITIES  PURCHASE
AND EXCHANGE AGREEMENT.

THIS WARRANT MAY NOT BE TRANSFERRED EXCEPT AS PROVIDED IN SECTION 17.

No. WN-                               Right to Purchase $_________ Aggregate
                                      Principal Amount of 12% Senior Convertible
                                      Notes of SUGEN, Inc.


                                   SUGEN, INC.

                  12% Senior Convertible Note Purchase Warrant



                  SUGEN,  INC., a Delaware  corporation,  hereby certifies that,
for value received,  [HOLDER] or registered assigns (the "Holder"), is entitled,
subject  to the terms set forth  below,  to  purchase  from the  Company,  by an
Exercise  Notice (such  capitalized  term and all other  capitalized  terms used
herein having the respective  meanings provided herein) given in accordance with
this  Warrant  at any time or from  time to time  during  the  Exercise  Period,
$_____________ aggregated principal amount of Notes at a purchase price per Note
equal to the Purchase Price.

                  As used herein the  following  capitalized  terms,  unless the
context otherwise requires, have the following respective meanings:

                  "Board  of  Directors"  means the  Board of  Directors  of the
         Company.

                  "Board  Resolution" means a copy of a resolution  certified by
         the  Secretary  or an  Assistant  Secretary of the Company to have been
         duly adopted by the Board of Directors,  or duly  authorized  committee
         thereof (to the extent  permitted by applicable law), and to be in full
         force and effect on the date of such  certification,  and  delivered to
         the Holder.

                  "Business  Day"  shall  mean any day  other  than a  Saturday,
         Sunday or a day on which  commercial  banks in The City of New York are
         authorized or required by law or executive order to remain closed.

<PAGE>

                  "Common Stock" includes the Company's  Common Stock, par value
         $.01 per share,  and the related  Preferred  Share Purchase Rights (and
         any  similar  rights  issued  with  respect  to the  Common  Stock)  as
         authorized on the date hereof,  and any other  securities into which or
         for which the Common  Stock or the  related  Preferred  Share  Purchase
         Rights (and any similar rights issued with respect to the Common Stock)
         may be converted or exchanged  pursuant to a plan of  recapitalization,
         reorganization, merger, sale of assets or otherwise.

                  "Common Stock Warrants"  means Common Stock Purchase  Warrants
         in the form of Exhibit 4 to this  Warrant  issued by the Company  which
         entitle the holder to purchase shares of Common Stock.

                  "Company" shall include SUGEN,  Inc. and any corporation  that
         shall succeed to or assume the obligation of SUGEN,  Inc.  hereunder in
         accordance with the terms hereof.

                  "Company Put Closing Date" shall have the meaning  provided in
         Section 2(a).

                  "Company Put Notice"  means a Company Put Notice,  in the form
         of Exhibit 2 to this Warrant.

                  "Company Put Threshold Event" means a period of 20 consecutive
         Trading Days occurring  after the date of this Warrant during which the
         arithmetic average of the daily Market Prices of the Common Stock shall
         have been at least equal to 175 percent of the Conversion Price.

                  "Conversion Notice" has the meaning to be provided or provided
         in the Notes.

                  "Conversion  Price"  shall have the  meaning  provided  in the
         Initial Notes,  subject to adjustment as provided  therein,  whether or
         not any of the Initial Notes is  outstanding at the relevant time under
         this Warrant.

                  "Conversion Shares" has the meaning to be provided or provided
         in the Notes.

                  "Event of Default"  has the meaning to be provided or provided
         in the Notes.

                  "Exercise  Notice"  means an  Exercise  Notice  in the form of
         Exhibit 1 to this Warrant.

                  "Exercise  Period"  means  the  period  from  the date of this
         Warrant to the Expiration Date.

                  "Expiration Date" means March 31, 2001.

                  "Fundamental  Change" shall have the meaning to be provided or
         provided in the Notes.

                  "Initial  Notes"  shall  mean the  Notes  (as  defined  in the
         Securities  Purchase  Agreement) and the Other Notes (as defined in the
         Securities Purchase Agreement).

                  "Majority  Holders"  means  at any time  the  holders  of this
         Warrant and the Other Warrants who hold this Warrant and Other Warrants
         and Warrant  Notes which,  based on 

                                      -2-
<PAGE>

         the principal amount of Notes and Other Notes which at such time may be
         purchased upon exercise of the unexercised portions hereof and thereof,
         represent a majority  of the  aggregate  principal  amount of Notes and
         Other Notes which may at such time be  purchased  upon  exercise of the
         unexercised portions hereof and thereof.

                  "Market  Price" with  respect to any security on any day shall
         mean the closing  bid price of such  security on such day on the Nasdaq
         or the NYSE or the AMEX,  as  applicable,  or, if such  security is not
         listed or admitted to trading on the Nasdaq,  the NYSE or the AMEX,  on
         the principal national securities exchange or quotation system on which
         such  security is quoted or listed or admitted to trading,  in any such
         case as  reported  by  Bloomberg,  L.P.  or, if not quoted or listed or
         admitted to trading on any  national  securities  exchange or quotation
         system,  the  average  of the  closing  bid and  asked  prices  of such
         security  on the  over-the-counter  market on the day in  question,  as
         reported by the National  Quotation Bureau  Incorporated,  or a similar
         generally accepted reporting service,  or if not so available,  in such
         manner as furnished by any New York Stock Exchange member firm selected
         from  time to time by the Board of  Directors  for that  purpose,  or a
         price  determined  in good  faith  by the  Board  of  Directors,  whose
         determination shall be conclusive and described in a Board Resolution.

                  "1934  Act"  means the  Securities  Exchange  Act of 1934,  as
         amended.

                  "1933 Act" means the Securities Act of 1933, as amended.

                  "Note" means any of the several 12% Senior  Convertible  Notes
         in the form of Exhibit 3 to this  Warrant  issued by the  Company  upon
         exercise  of this  Warrant by the Holder or  exercise by the Company of
         its rights under Section 1(b).

                  "Other Notes" means the 12% Senior  Convertible Notes issuable
         or issued pursuant to the Other Warrants.

                  "Other  Securities  Purchase  Agreements"  means  the  several
         Securities  Purchase and Exchange  Agreements,  dated as of the date of
         the Securities Purchase  Agreement,  by and between the Company and the
         several buyers named therein.

                  "Other  Warrants"  means  the  12%  Senior   Convertible  Note
         Purchase  Warrants  issued  pursuant to the Other  Securities  Purchase
         Agreements.

                  "Person"  means  an  individual,   partnership,   corporation,
         limited liability company,  trust or incorporated  organization,  and a
         government or a governmental agency or political subdivision.

                  "Preferred  Share Purchase  Rights" means the Preferred  Share
         Purchase Rights issued or issuable pursuant to the Rights Agreement (or
         any similar rights  hereafter issued by the Company with respect to the
         Common Stock).

                  "Purchase  Price"  means  with  respect  to any Note an amount
         equal to the original principal amount of such Note.

                  "QIB" means a  "qualified  institutional  buyer" as defined in
         Rule 144A.

                  "Redemption Consideration" means:

                                      -3-
<PAGE>

                           (1) Common Stock Warrants which initially (x) entitle
                  the holder  thereof  to  purchase a number of shares of Common
                  Stock  equal to the  quotient  obtained  by  dividing  (i) the
                  principal  amount  of Notes  for which  this  Warrant  remains
                  unexercised immediately prior to redemption of this Warrant on
                  the  Redemption  Date by (ii) the  Conversion  Price in effect
                  immediately  prior  to  redemption  of  this  Warrant  on  the
                  Redemption  Date and (y) have a Purchase  Price (as defined in
                  the Common Stock  Warrant)  equal to the  Conversion  Price in
                  effect  immediately prior to redemption of this Warrant on the
                  Redemption  Date,  subject to  adjustment  as  provided in the
                  Common Stock Warrants; and

                           (2) an amount in cash equal to the product of (x) the
                  principal  amount  of Notes  for which  this  Warrant  remains
                  unexercised immediately prior to redemption of this Warrant on
                  the  Redemption  Date  times  (y)  the  applicable  Redemption
                  Percentage.

                  "Redemption  Date" shall have the meaning  provided in Section
         5.

                  "Redemption  Notice"  means a notice  from the  Company to the
         Holder which states:

                           (1) that this Warrant has been called for  redemption
                  pursuant to Section 5;

                           (2)  the   remaining   principal   amount   of  Notes
                  purchasable  upon exercise of the unexercised  portion of this
                  Warrant  (determined  on the date  the  Redemption  Notice  is
                  given);

                           (3) based on the unexercised  portion of this Warrant
                  on the date the  Redemption  Notice  is given,  the  number of
                  shares of Common Stock which may be purchased upon exercise of
                  the Common Stock Warrant to be issued to the Holder as part of
                  the  Redemption  Consideration,  stated  without regard to any
                  adjustment  therein  prior  to the  Redemption  Date,  and the
                  Purchase  Price (as  defined in the Common  Stock  Warrant) of
                  such  Common  Stock  Warrant,  stated  without  regard  to any
                  adjustment thereof prior to the Redemption Date;

                           (4) based on the unexercised  portion of this Warrant
                  on the date the Redemption  Notice is given, the amount of the
                  cash portion of the Redemption Consideration of this Warrant;

                           (5) the Redemption Date;

                           (6) the place where this  Warrant  shall be delivered
                  and the Redemption Consideration paid and delivered; and

                           (7) that the right to  exercise  any  portion of this
                  Warrant that is being  redeemed and which has not  theretofore
                  been exercised  shall  terminate at 12:00  midnight,  New York
                  City  time,  on the  Trading  Day  immediately  preceding  the
                  Redemption Date.

                  "Redemption  Percentage"  means with respect to any Redemption
         Date during any period set forth below the  percentage  set forth below
         opposite such period:

                                      -4-
<PAGE>

<TABLE>
<CAPTION>
                                                                                                    Redemption
                  Date                                                                              Percentage
                  ----                                                                              ----------
                  <S>                                                                                    <C>
                  Date of this Warrant to date that is 365 days after such date                          110%

                  From  and  after  date  that is 366  days  after  date of this  Warrant  to
                  Expiration Date                                                                        105%

</TABLE>

                  "Registration  Statement"  shall have the meaning  provided in
         the Securities Purchase Agreement.

                  "Repurchase  Event"  shall have the  meaning to be provided or
         provided in the Notes.

                  "Restricted Securities" means securities that are not eligible
         for resale pursuant to Rule 144(k) under the 1933 Act (or any successor
         provision).

                  "Rights  Agreement"  means the Rights  Agreement,  dated as of
         August 1, 1995,  by and between the  Company and Boston  EquiServe,  as
         Rights  Agent,  as  amended  from time to time in  accordance  with its
         terms.

                  "Rule 144A" means Rule 144A as promulgated under the 1933 Act.

                  "SEC" means the Securities and Exchange Commission.

                  "SEC  Effective  Date" shall have the meaning  provided in the
         Securities Purchase Agreement.

                  "Securities  Purchase Agreement" means the Securities Purchase
         and Exchange Agreement,  dated as of March 19, 1999, by and between the
         Company and the original Holder of this Warrant.

                  "Trading  Day"  means  a day  on  which  either  the  national
         securities  exchange or Nasdaq  which then  constitutes  the  principal
         securities market for the Common Stock is open for general trading.

                  "Transaction Documents" shall have the meaning provided in the
         Securities Purchase Agreement.

                  "Warrant  Closing  Date"  shall have the  meaning  provided in
         Section 2(a).

                  1. Exercise of Warrant; Company Put Right.

                  (a)  Exercise by Holder.  This Warrant may be exercised by the
Holder in full or in part at any time or from time to time  during the  Exercise
Period, in the following amounts during the following periods:

                  (1) during the period  from the date  hereof to  December  31,
         2000,  in any calendar  quarter,  this Warrant may be exercised for not
         more than one-third of the original  aggregate  principal amount of the
         Notes issuable upon exercise of this Warrant, 

                                      -5-
<PAGE>

         subject to the provisions of Section 1(c); provided,  however, that any
         such  amount  for  which  this  Warrant  is not  exercised  in any such
         calendar quarter may not be carried forward to any subsequent  calendar
         quarter in such period; and

                  (2) during the period  from  January 1, 2001 to the end of the
         Exercise Period this Warrant may be exercised in full.

                  To exercise this Warrant,  the Holder shall (x) surrender this
Warrant to the  Company,  (y) give an  Exercise  Notice  (duly  executed  by the
Holder) to the Company,  and (z) on the applicable  Warrant  Closing Date,  make
payment,  in cash or by certified or official bank check payable to the order of
the Company, or by wire transfer of funds to the account of the Company, in each
such case,  in an amount equal to the Purchase  Price of the Note  designated by
the Holder in the Exercise  Notice for such Note. On any partial  exercise,  the
Company  will  forthwith  issue and deliver to or upon the order of the Holder a
new  Warrant  or  Warrants  of like  tenor,  in the name of the Holder or as the
Holder  (upon  payment  by the  Holder of any  applicable  transfer  taxes)  may
request,  providing  in the  aggregate  on the  face or  faces  thereof  for the
purchase of the  aggregate  principal  amount of Notes for which such Warrant or
Warrants  may still be  exercised.  An  Exercise  Notice may be  surrendered  by
telephone line facsimile  transmission to the telephone numbers shown thereon or
such other  numbers for the Company as shall have been  specified  in writing to
the Holder by the  Company;  provided,  however,  that if an Exercise  Notice is
given to the Company by telephone line facsimile  transmission  the Holder shall
send an original of such Exercise Notice to the Company within ten Business Days
after  such  Exercise  Notice  is so given  to the  Company;  provided  further,
however,  that any  failure  or delay on the part of the  Holder in giving  such
original of any Exercise  Notice shall not affect the validity of or the date on
which such Exercise Notice is so given by telephone line facsimile transmission.

                  (b)  Exercise  of  Company  Put  Right.  (1) If a Company  Put
Threshold Event occurs during the Exercise  Period,  then at any time within ten
Business Days after such Company Put Threshold Event, the Company shall have the
right on one occasion only with respect to such Company Put  Threshold  Event to
require the Holder to purchase  Notes that are subject to this  Warrant and that
the Holder has not  previously  purchased,  in the following  amounts during the
following periods:

                  (A) during the period  from the date  hereof to  December  31,
         2000,  in any  calendar  quarter  the Company may require the Holder to
         purchase a principal amount of Notes that is not more than one-third of
         the original  principal  amount issuable upon exercise of this Warrant;
         provided,  however, that any such amount for which the Company does not
         exercise  its rights in any such  calendar  quarter  may not be carried
         forward to any subsequent calendar quarter;  provided further, however,
         that if a Company Put Threshold Event occurs and the arithmetic average
         of the  Market  Price of the  Common  Stock  during  the  period  of 20
         consecutive  Trading  Days used to  determine  the  occurrence  of such
         Company Put Threshold Event shall have been at least 200 percent of the
         Conversion  Price,  then the  limitation  of this  clause  (A) shall be
         inapplicable to such Company Put Threshold Event; and

                  (B) during the period  from  January 1, 2000 to the end of the
         Exercise Period,  the Company may require the Holder to purchase all or
         any part of the Notes for which this Warrant is unexercised.

                                      -6-
<PAGE>

To exercise its right to require the Holder to purchase Notes, the Company shall
give the  Holder a Company  Put  Notice and the  Holder  shall be  obligated  to
purchase Notes as specified in such Notice if the  requirements  of this Section
1(b) are satisfied.

                  (2) The  Company  shall be  entitled  to give the  Company Put
Notice only if the following requirements are met:

                  (A) On the date the  Company  Put  Notice  is given and at all
         times  thereafter  to and  including  the Company Put Closing  Date, no
         event which, if a Note were  outstanding,  would constitute an Event of
         Default  under  and as  defined  in the Notes or which  with  notice or
         passage of time,  or both,  would become an Event of Default shall have
         occurred and be continuing;

                  (B) On the date the  Company  Put  Notice  is given and at all
         times  thereafter  to and  including  the Company Put Closing  Date, no
         event which, if a Note were outstanding,  would constitute a Repurchase
         Event or event  which with  notice or passage of time,  or both,  would
         become a Repurchase Event shall have occurred and be continuing;

                  (C) The SEC  Effective  Date  for the  Registration  Statement
         shall have  occurred  on or before the date the  Company  Put Notice is
         given and on the date the  Company Put Notice is given and at all times
         thereafter   to  and   including  the  Company  Put  Closing  Date  the
         Registration Statement shall be effective and available for use for the
         resale of the Conversion  Shares issuable upon conversion of the Notes;
         and

                  (D) On the date the Company gives the Company Put Notice,  the
         Company  shall have  exercised its rights under Section 1(b) of each of
         the Other  Warrants  to require  the  holders of the Other  Warrants to
         purchase  Other  Notes in an amount  which is pro rata among the Holder
         and the holders of the Other Warrants,  based on the original principal
         amount of Notes for which this Warrant was  exercisable  and respective
         original  principal  amounts  of the  Other  Notes  for which the Other
         Warrants were exercisable.

                  (c)  Acceleration of Exercise By Holder.  Notwithstanding  any
limitation on exercise of this Warrant contained in Section 1(a), if the Company
shall have given or been  required to give to the Holder a notice in  accordance
with Section 7 or if a  Fundamental  Change  shall have  occurred or there shall
have been any public  announcement  of any event or transaction  that would be a
Fundamental  Change,  then  thereafter  the  limitations  in Section 1(a) on the
amount of this Warrant  which may be exercised by the Holder shall not be of any
further force or effect and the Holder may exercise this Warrant in whole at any
time or in part from time to time.

                  2.  Delivery of and Payment for each Note,  etc., on Exercise.
(a) The date  and  time of each  issuance  and  sale of a Note  pursuant  to the
exercise  by the Holder of its rights  under  Section  1(a) shall be not earlier
than  three  Business  Days  or  more  than 90 days  after  the  Holder  gives a
particular  Exercise  Notice (unless a later date is agreed to by the Holder) as
specified by the Holder in such Exercise Notice (each a "Warrant Closing Date").
The date and time of issuance and sale of a Note pursuant to the exercise of the
Company's rights under Section 1(b) shall be the date which is 60 days after the
Company gives the Company Put Notice, or such earlier date (not sooner than five
Business  Days after the date the  Company  gives such  Company  Put  Notice) as
specified  by the Holder by notice to the  Company  

                                      -7-
<PAGE>

(the "Company Put Closing Date").  The closing of such exercise shall occur at a
location and time of day as mutually agreed by the Holder and the Company.

                  (b) At the  closing  on each  Warrant  Closing  Date or on the
Company Put Closing  Date, as the case may be, upon the terms and subject to the
conditions of this Warrant, the Company at its expense (including the payment by
it of any  applicable  issue or stamp taxes) will cause to be issued in the name
of and delivered to the Holder,  or as the Holder (upon payment by the Holder of
any applicable  transfer  taxes) may direct,  one or more Notes in the aggregate
principal amount stated in the applicable Exercise Notice or Company Put Notice,
as the case may be, in such denominations as may be requested by the Holder, and
the Holder shall pay to the Company an amount  equal to the  Purchase  Price for
the Note or Notes issuable by the Company to the Holder on such Warrant  Closing
Date or on the Company Put Closing Date, as the case may be.

                  (c) Except as  otherwise  specifically  provided in Section 3,
upon  exercise  of this  Warrant by the Holder or exercise by the Company of its
rights under Section 1(b) as provided herein, the Company's  obligation to issue
and deliver the Note or Notes shall be absolute and unconditional,  irrespective
of the  absence of any action by the Holder to enforce  the same,  any waiver or
consent  with  respect to any  provision  hereof,  the  recovery of any judgment
against  any Person or any action to enforce  the same,  any failure or delay in
the  enforcement  of any other  obligation of the Company to the Holder,  or any
setoff,  counterclaim,  recoupment,  limitation or termination, or any breach or
alleged  breach  by the  Holder or any other  Person  of any  obligation  to the
Company or any violation or alleged  violation of law by the Holder or any other
Person,  and irrespective of any other  circumstance which might otherwise limit
such  obligation of the Company to the Holder in connection  with such exercise.
An Exercise  Notice shall be deemed for all purposes to be in proper form unless
the Company notifies the Holder by telephone line facsimile  transmission within
two Business Days after an Exercise Notice has been given (which notice from the
Company  shall  specify all defects in such  Exercise  Notice) and any  Exercise
Notice  containing  any such defect shall  nonetheless  be effective on the date
given if the Holder promptly undertakes to correct all such defects.

                  3. Company Conditions.  The obligation of the Company to issue
a Note on a particular  Warrant Closing Date or on the Company Put Closing Date,
as the case may be, is subject to the  satisfaction  of the condition  precedent
that on such  Warrant  Closing Date or on the Company Put Closing  Date,  as the
case may be, the  representations and warranties of the Holder made in Section 3
of the Securities  Purchase Agreement (insofar as they relate to the Notes to be
issued on such  Warrant  Closing Date or the Company Put Closing  Date),  as the
case may be, or made by the Holder  pursuant  to Section 17, as the case may be,
shall be true and  correct  as if made on such  Warrant  Closing  Date or on the
Company Put Closing  Date,  as the case may be (unless  waived by the Company in
its sole discretion).

                  4. Holder Conditions. The obligation of the Holder to purchase
a Note on a particular  Warrant Closing Date or on the Company Put Closing Date,
as the case may be, is subject to the  satisfaction of the following  conditions
precedent  (any  or all of  which  may be  waived  by  the  Holder  in its  sole
discretion):

                  (a) On such Warrant Closing Date or on the Company Put Closing
Date, as the case may be, no legal action,  suit or proceeding  shall be pending
or threatened which seeks to restrain or prohibit the transactions  contemplated
by this Warrant or the other Transaction Documents;

                                      -8-
<PAGE>

                  (b)  The   representations   and  warranties  of  the  Company
contained in the  Transaction  Documents shall have been true and correct on the
respective  dates of the Transaction  Documents and shall be true and correct on
such Warrant  Closing Date or the Company Put Closing  Date, as the case may be,
as if made on and as of such  Warrant  Closing  Date or the  Company Put Closing
Date, as the case may be (except for representations made as of a specific date,
which  representations  shall be true and correct as of such date and except for
the  approvals  referred to in clauses  (1)  through (4) of Section  4(h) of the
Securities  Purchase  Agreement,  which shall have been  obtained on or prior to
such  date),  and on or before  such  Warrant  Closing  Date or the  Company Put
Closing Date, as the case may be, the Company shall have performed all covenants
and agreements of the Company contained in the Transaction Documents required to
be  performed  by the Company on or before such  Warrant  Closing Date or on the
Company Put Closing Date, as the case may be;

                  (c) On such Warrant Closing Date or on the Company Put Closing
Date,  as the case may be, no event  which,  if such Note were  outstanding  (1)
would  constitute an Event of Default under and as defined in such Note or, with
the giving of notice or the passage of time, or both,  would constitute an Event
of  Default  under  and as  defined  in such Note  shall  have  occurred  and be
continuing  or (2) would  constitute a Repurchase  Event under and as defined in
such Note or, with the giving of notice or the passage of time,  or both,  would
constitute  a  Repurchase  Event  under and as  defined  in such Note shall have
occurred and be continuing;

                  (d)  The  Company  shall  have  delivered  to the  Holder  its
certificate,  dated such Warrant  Closing Date, or the Company Put Closing Date,
as the case may be, duly executed by its Chief  Executive  Officer to the effect
set forth in subparagraphs (a), (b), and (c) of this Section 4;

                  (e) On such  Warrant  Closing  Date or the Company Put Closing
Date,  as the case may be,  (i)  trading  in  securities  on the New York  Stock
Exchange,  Inc., the American Stock Exchange, Inc. or Nasdaq shall not have been
suspended or  materially  limited and (ii) a general  moratorium  on  commercial
banking activities in the State of California or the State of New York shall not
have been declared by either federal or state authorities; and

                  (f) In the case of the  exercise  by the Company of its rights
under Section 1(b), the requirements and conditions precedent of Section 1(b)(2)
shall have been satisfied.

                  5. Redemption. (a) If (x) the Company shall exercise its right
to  redeem  all  outstanding  Initial  Notes,  all  outstanding  Notes  and  all
outstanding  Other Notes, in each such case pursuant to Section 1.2 thereof,  or
(y) the Company shall have  satisfied and  discharged  all  outstanding  Initial
Notes, all outstanding  Notes and all outstanding Other Notes, in each such case
in accordance with Article VI thereof,  then in the case of either the preceding
clause  (x) or (y) the  Company  shall  have the right on one  occasion  only to
redeem all of this  Warrant in  accordance  with this  Section 5 by issuance and
delivery  and  payment  to the  Holder  of  the  Redemption  Consideration.  The
Company's right to redeem this Warrant shall be exercised by a Redemption Notice
from the Company to the Holder given not less than 45 or more than 60 days prior
to the date on which such  redemption is to occur (the  "Redemption  Date").  If
this  Warrant is called for  redemption  pursuant to this Section 5, the Company
shall simultaneously  therewith call for redemption all of the Other Warrants in
accordance with their terms that are similar to this Section 5.

                  (b) If the Company  shall have  exercised  its right to redeem
this Warrant,  then (1) the Company shall thereafter no longer have the right to
exercise  its rights under  Section 

                                      -9-
<PAGE>

1(b) and (2) the  Holder's  right to exercise  this Warrant  shall  terminate at
12:00 midnight,  New York City time, on the Trading Day preceding the applicable
Redemption Date unless, in the case of this clause (2),  otherwise agreed by the
Company or the Company  shall fail to issue and  deliver and pay the  Redemption
Consideration  in full to the Holder as and when due.  If this  Warrant is being
redeemed in  connection  with a  redemption  described  in clause (x) of Section
5(a),  then the  Redemption  Notice  given to the Holder shall be deemed for all
purposes of any Notes issued to the Holder after such Redemption Notice is given
which  Notes  are  outstanding  on  the  Redemption  Date  to be the  notice  of
redemption  required  by  Section  1.2 of such  Notes to  redeem  such  Notes in
accordance with the terms thereof on the Redemption Date.

                  (c) From and after the Redemption  Date, the Company shall, at
the place specified in the Redemption Notice,  upon presentation or surrender to
the Company of this  Warrant by or on behalf of the Holder,  deliver or cause to
be  delivered,  and pay or  cause  to be paid by wire  transfer  of funds to the
account specified for such purpose by the Holder to or upon the written order of
the Holder the Redemption Consideration.  From and after the Redemption Date and
upon the delivery  and payment of the  Redemption  Consideration  in full to the
Holder,  this Warrant shall  terminate and become void and all rights  hereunder
shall cease.

                  6. Further  Assurances.  The Company will take all action that
may be  necessary  or  appropriate  in order that the  Company  may  validly and
legally issue fully paid and nonassessable shares of stock, free from all taxes,
liens and charges with respect to the issue  thereof,  on the exercise of all or
any portion of this Warrant from time to time outstanding.

                  7.  Notices to Holder  Prior to Certain  Actions.  The Company
shall give notice to the Holder of the actions  specified  in Section 2.6 of the
Notes as and when required by the Notes, whether or not any Note is outstanding,
and Section 2.6 of the Notes (and any related  definitions of capitalized  terms
used  therein) are hereby  incorporated  herein as if set forth in full.  In the
case of any such action of which the Company  gives such notice to the Holder or
is required to give such notice to the Holder,  the Holder  shall be entitled to
give an Exercise  Notice for this Warrant and a  Conversion  Notice for the Note
issuable upon exercise of this Warrant by reason of such Exercise Notice,  which
Exercise  Notice and Conversion  Notice are contingent on the completion of such
action.

                  8.  Reservation  of Stock,  etc.,  Issuable on  Conversion  of
Notes.  The  Company  will at all times  comply  with  Section 2.5 of the Notes,
whether or not any Note is  outstanding,  and  Section 2.5 of the Notes (and any
related  definitions of capitalized terms used therein) are hereby  incorporated
herein as if set forth in full.

                  9.  Transfer  of  Warrant.  This  Warrant  shall  inure to the
benefit of the  successors  to and assigns of the Holder.  This  Warrant and all
rights  hereunder,  in whole or in part, are registrable at the office or agency
of the Company referred to below by the Holder in Person or by the Holder's duly
authorized attorney,  upon surrender of this Warrant properly endorsed.  If this
Warrant or any predecessor  instrument  shall have been exercised in part by the
Holder or the  Holder's  predecessor  in  interest  within 90 days  prior to the
transfer of this Warrant and by reason of such  exercise  any Warrant  issued on
such transfer  shall,  pursuant to Section 1(a), be exercisable  for a principal
amount of Notes that is less than one-third of the aggregate principal amount of
Notes  shown on the face of the  Warrant  so issued on such  transfer,  then the
Company  shall  place a notation  on the  Warrant so issued as to the  remaining
portion less than such one-third  that is so  exercisable  and the period during
which such limitation shall apply.

                                      -10-
<PAGE>

                  10. Register of Warrants.  The Company shall maintain,  at the
principal  office of the Company (or such other  office as it may  designate  by
notice to the Holder), a register in which the Company shall record the name and
address of the Person in whose name this Warrant has been issued, as well as the
name and address of each successor and prior owner of such Warrant.  The Company
shall  be  entitled  to treat  the  Person  in whose  name  this  Warrant  is so
registered as the sole and absolute owner of this Warrant for all purposes.

                  11. Exchange of Warrant.  This Warrant is  exchangeable,  upon
the  surrender  hereof  by the  Holder at the  office  or agency of the  Company
referred  to in  Section  10,  for  one or  more  new  Warrants  of  like  tenor
representing in the aggregate the right to purchase the principal  amount of the
Notes which may be purchased  hereunder,  each of such new Warrants to represent
the right to purchase such principal  amount of the Notes as shall be designated
by the Holder at the time of such surrender.

                  12.  Replacement  of  Warrant.  On receipt  by the  Company of
evidence reasonably  satisfactory to it of the ownership of and the loss, theft,
destruction or mutilation of this Warrant and (a) in the case of loss,  theft or
destruction, of indemnity from the Holder reasonably satisfactory in form to the
Company (and without the requirement to post any bond or other security), or (b)
in the case of mutilation,  upon surrender and cancellation of this Warrant, the
Company will  execute and deliver to the Holder a new Warrant of like tenor.  In
connection  with the issuance of any such new  Warrant,  the Holder shall pay or
reimburse the Company for the  reasonable  and  documented  attorneys'  fees and
expenses  incurred by the Company in connection  therewith (but not in excess of
$500.00 for each such issuance).

                  13. Warrant  Agent.  The Company may, by written notice to the
Holder,  appoint the transfer  agent and  registrar  for the Common Stock or any
institution that would be qualified pursuant to the Trust Indenture Act of 1939,
as amended,  to serve as indenture  trustee for the Notes as the Company's agent
for the purpose of issuing  Notes on the  exercise of this Warrant by the Holder
pursuant to Section  1(a) or the  exercise  by the  Company of its rights  under
Section 1(b), and the Company may, by written  notice to the Holder,  appoint an
agent  having an office in the  United  States of  America  for the  purpose  of
exchanging  this  Warrant  pursuant to Section 11, and  replacing  this  Warrant
pursuant  to  Section  12,  or any of the  foregoing,  and  thereafter  any such
exercise,  exchange or  replacement,  as the case may be,  shall be made at such
office by such agent.

                  14. Remedies.  The Company stipulates that the remedies at law
of the Holder in the event of any default or  threatened  default by the Company
in the  performance  of or compliance  with any of the terms of this Warrant are
not and will not be adequate,  and that such terms may be specifically  enforced
by a decree for the specific performance of any agreement contained herein or by
an injunction against a violation of any of the terms hereof or otherwise.

                  15.  No  Rights  or  Liabilities  as  Holder  of  Note or as a
Stockholder.  This Warrant  shall not entitle the Holder to any voting rights or
other rights as a stockholder of the Company.  Except as otherwise  specifically
provided  in this  Warrant,  this  Warrant  shall not  entitle the Holder to any
rights  as a  holder  of a Note.  Nothing  contained  in this  Warrant  shall be
construed  as  conferring  upon the Holder the right to vote or to consent or to
receive notice as a stockholder of the Company on any matters or with respect to
any rights whatsoever as a stockholder of the Company.  No dividends or interest
shall  be  payable  or  accrued  in  respect  of this  Warrant  or the  interest
represented  hereby or the  Notes  purchasable  hereunder  or the  Common  Stock
issuable  upon  exercise of the Notes until,  and only to the extent that,  this

                                      -11-
<PAGE>

Warrant shall have been exercised in accordance  with its terms or any such Note
shall have been converted in accordance with its terms, as the case may be.

                  16. Notices,  etc. All notices and other  communications  from
the Company to the Holder shall be mailed by first class certified mail, postage
prepaid, at such address as may have been furnished to the Company in writing by
the Holder or at the  address  shown for the Holder on the  register of Warrants
referred to in Section 10.

                  17.  Transfer  Restrictions.  This Warrant has not been and is
not  being  registered  under  the  provisions  of the  1933  Act  or any  state
securities  laws  and  this  Warrant  may  not be  transferred  unless  (1)  the
transferee  is an  "accredited  investor"  (as defined in Regulation D under the
1933 Act) or a QIB in a transfer  that meets the  requirements  of Rule 144A and
(2) in the  case  of a  transfer  to any  Person  described  in the  immediately
preceding  clause (1) who is not a QIB, the Holder  shall have  delivered to the
Company  an opinion  of  counsel,  reasonably  satisfactory  in form,  scope and
substance  to the  Company,  to the  effect  that  this  Warrant  may be sold or
transferred without  registration under the 1933 Act. Prior to any such transfer
to a transferee  who is not a QIB, such  transferee  shall have  represented  in
writing to the Company that such  transferee has requested and received from the
Company  all  information  relating  to the  business,  properties,  operations,
condition  (financial  or other),  results of  operations  or  prospects  of the
Company  deemed  relevant  by such  transferee;  that such  transferee  has been
afforded  the  opportunity  to ask  questions  of  the  Company  concerning  the
foregoing  and has had the  opportunity  to obtain and  review the  Registration
Statement and the prospectus  relating thereto,  each as amended or supplemented
to the  date  of  transfer  to  such  transferee,  and  the  reports  and  other
information  concerning the Company which at the time of such transfer have been
filed by the  Company  with the SEC  pursuant  to the  1934  Act and  which  are
incorporated by reference in such prospectus as of the date of such transfer. If
such transfer is intended to assign the rights and  obligations  under  Sections
5(a),  5(b), 8, 9 and 10 of the  Securities  Purchase  Agreement,  such transfer
shall  otherwise  be made in  compliance  with Section  10(j) of the  Securities
Purchase Agreement.

                  18. Rule 144A Information Requirement. Within the period prior
to the  expiration of the holding  period  applicable to sales hereof under Rule
144(k) under the 1933 Act (or any successor  provision),  the Company  covenants
and  agrees  that it shall,  during  any  period in which it is not  subject  to
Section  13 or 15(d)  under the 1934 Act,  make  available  to the Holder or the
holder of any Note issued pursuant to this Warrant,  Common Stock Warrant issued
upon redemption of this Warrant or shares of Common Stock issued upon conversion
or exercise  thereof which  continue to be  Restricted  Securities in connection
with any sale hereof or thereof and any  prospective  purchaser  of this Warrant
from the Holder, the information  required pursuant to Rule 144A(d)(4) under the
1933 Act upon the  request  of the  Holder or such  holder and it will take such
further action as the Holder may reasonably request,  all to the extent required
from time to time to enable the Holder to sell this Warrant without registration
under the 1933 Act within the limitation of the exemption provided by Rule 144A,
as Rule 144A may be amended  from time to time.  Upon the request of the Holder,
the Company will deliver to the Holder a written  statement as to whether it has
complied with such requirements.

                  19. Legend. Unless theretofore registered for resale under the
1933 Act,  each Note issued upon  exercise of this Warrant shall bear the legend
appearing on the first page of the Note.

                  20. Limitation of Holder's  Liability.  In connection with any
exercise by the Company of its rights under Section  1(b),  the Holder (a) shall
be liable for damages from breach

                                      -12-
<PAGE>

of the Holder's  obligations relating to such exercise only if and to the extent
such breach shall have been determined by final judgment, not subject to further
appeal,  of a court of competent  jurisdiction  to have resulted from conduct of
the Holder which constitutes gross negligence or willful  misconduct,  (b) shall
have no liability  in  connection  with any dispute or legal action  relating to
such  exercise  if at any time  prior  to a final  judgment  referred  to in the
immediately  preceding  clause (a) the Holder  shall have  tendered the Purchase
Price of all Notes  the  purchase  of which is in  dispute  (in  which  case the
Company  shall issue such Notes to the Holder in  accordance  with this Warrant)
and (c) if the immediately  preceding clause (b) is  inapplicable,  shall not in
any event be liable for damages or liability arising from or in any way relating
to any breach or  alleged  breach by the  Holder of its  obligations  under this
Warrant or otherwise in  connection  with this Warrant in an amount in excess of
the principal amount of Notes issuable upon exercise of the unexercised  portion
of this Warrant.  This Warrant and the terms and  provisions  hereof are for the
sole and exclusive benefit of the Holder, the Company and the Holder's permitted
assigns and in no event shall the Holder have any  liability to any  stockholder
or creditor of the Company or any other Person (other than the Company,  subject
to the  limitations  on  liability to the Company  contained  herein) in any way
relating  to or  arising  from this  Warrant  or the  transactions  contemplated
hereby.

                  21.  Miscellaneous.  (a) This Warrant and any terms hereof may
be changed,  waived,  discharged or terminated  only by an instrument in writing
signed by the party against whom enforcement of such change,  waiver,  discharge
or  termination  is sought.  This  Warrant  shall be  construed  and enforced in
accordance  with and governed by the internal  laws of the State of  California.
The headings in this Warrant are for purposes of reference  only,  and shall not
limit  or  otherwise  affect  any  of  the  terms  hereof.   The  invalidity  or
unenforceability  of any provision hereof shall in no way affect the validity or
enforceability of any other provision.

                  (b) Prior to issuance of any Note or Other Note upon  exercise
of this Warrant or any Other Warrant,  the terms and provisions of the Notes and
Other  Notes  which may be so  issued  upon such  exercise  may not be  changed,
waived,  discharged  or  terminated  unless such  change,  waiver,  discharge or
termination is in writing signed by the Majority Holders,  provided that no such
change, waiver, discharge or termination shall, prior to issuance of any Note or
Other  Note,  without  the  consent of the  Holder and the  holders of the Other
Warrants affected  thereby,  (i) extend the scheduled final maturity of any such
Note or Other Note, or reduce the rate or extend the time of payment of interest
(other  than as a  result  of  waiving  the  applicability  of any  post-default
increase in interest  rates)  thereon or reduce the principal  amount thereof or
the Optional Redemption Consideration (as defined therein), Repurchase Price (as
defined  therein) or Registration  Repurchase Price (as defined  therein),  (ii)
amend,  modify or waive any  provision of Section 8.3 thereof,  (iii) reduce any
percentage  specified  in, or  otherwise  modify,  the  definition  of "Majority
Holders" in any such Note or Other Note,  or (iv) except as provided in any such
Note or other Note, change the method of calculating the "Conversion  Price" (as
defined therein) in a manner adverse to the Holder.

                  22.  Attorneys' Fees. In any litigation,  arbitration or court
proceeding  between the Company and Holder relating hereto, the prevailing party
shall be entitled to attorneys'  fees and expenses and all costs of  proceedings
incurred in enforcing this Warrant.

                                      -13-
<PAGE>

                  IN WITNESS WHEREOF,  the Company has caused this Warrant to be
executed on its behalf by one of its officers thereunto duly authorized.

Dated: March 24, 1999               SUGEN, INC.



                                    By:  ________________________________
                                                    James L. Knighton
                                                Senior Vice President and
                                                 Chief Financial Officer



                                      -14-


Contacts:         SUGEN, Inc.                          Burns McClellan, Inc.
                  James L. Knighton                    Stephanie Diaz (media)
                  Senior Vice President and                   (415) 352-6262
                  Chief Financial Officer
                  (650) 553-8300
                  [email protected]
 


For Immediate Release:
- ----------------------

            SUGEN, INC. ANNOUNCES $28.0 MILLION FINANCING BY PRIVATE
                      PLACEMENT OF SENIOR CONVERTIBLE NOTES

South San Francisco,  CA, March 22, 1999 - SUGEN, Inc. (NASDAQ:  SUGN) announced
today the execution of purchase  agreements  for the private  placement of $28.0
million  principal amount of 12% Senior  Convertible  Notes due 2002. The Notes,
which are 144A  eligible,  are  convertible  into SUGEN  Common Stock at a fixed
price equal to $20.50 per share,  representing  an approximate  20% premium over
recent average market prices.  Interest on the Notes may be paid in SUGEN Common
Stock or cash at the Company's option.

As part of the Note placement,  purchasers will be issued Warrants to acquire up
to an additional $21.0 million  principal  amount of the 12% Senior  Convertible
Notes  which  will  mature  on the third  anniversary  date of  issuance.  These
"Warrant  Notes"  will have  principally  the same terms and  conditions  as the
original  Notes.  The Warrants to purchase the Warrant Notes will be exercisable
for a period of two years  following  the  closing  date of the  issuance of the
Notes.  The Company will have the right, at its option,  to require the exercise
of the  Warrants  by the  holders  in the event  that the  closing  price of the
Company's Common Stock exceeds certain levels during the term of the Warrants.

An  important  element  to this  financing  is that the  outstanding  balance of
approximately  $5.6 million of the 5% Senior  Custom  Convertible  issued by the
company in September 1997 with a floating conversion mechanism will be converted
into SUGEN Common Stock or exchanged for additional 12% Senior Convertible Notes
due 2002 and  Warrants.  "We believe the  retirement  of the 1997 Notes to be an
important  step  toward  continued  stock  appreciation.  This is the first of a
number  of  financing  opportunities  we are  currently  examining  and our goal
remains  to  avoid  doing a  large  publicly  registered  offering  this  year",
commented Stephen Evans-Freke, Chairman and Chief Executive Officer.

"This financing  provides for a considerable  amount of the cash we will need in
order to bring our two lead compounds through late stage clinical  development,"
commented James L. Knighton,  Senior Vice President and Chief Financial  Officer
of  SUGEN.  "The  structure  of the  Note  and  Warrant  placement  has  several
advantages.  First, it provides for

<PAGE>

the conversion of the Notes at a significant premium to today's prices;  second,
the Warrants  offer the potential for SUGEN to receive  significantly  more cash
over the next two years; and third, it permits us, at our option,  to redeem the
Notes and Warrants at any time prior to their maturity or exercise."

The closing of the placement of the Notes and Warrant Notes is expected to occur
on March 24, 1999, subject to the satisfaction of closing  conditions  customary
for transactions of this type. Diaz & Altschul Capital, LLC, New York, New York,
was the placement agent in the transaction.  Delta Opportunity Fund, Ltd., which
is  advised  by  Diaz  &  Altschul  Advisors,  LLC,  is  lead  investor  in  the
transaction. SUGEN has agreed to file a registration statement for the resale of
the shares of Common Stock  acquired on  conversion of the Notes and the Warrant
Notes  within 30 days  after the  closing  date.  The  summary  of the terms and
conditions  of the Notes,  Warrant  Notes and  Warrants  included  in this press
release is not intended to be a a complete  summary of the terms and  conditions
of such  securities.  Copies of the Notes,  Warrant Notes,  Warrants and related
documents will be filed with the SEC on a Form 8-K after the closing date.

SUGEN,  Inc.  is a  biopharmaceutical  company  focused  on  the  discovery  and
development  of small  molecule  drugs which  target  specific  cellular  signal
transduction  pathways.  SUGEN  currently has two cancer  products in late stage
clinical  trials:  SU101 (a PDGF  receptor  inhibitor) is in Phase III trials in
refractory  brain  cancer,  will be entering  Phase III in  refractory  prostate
cancer this year, and is in Phase II in ovarian and non-small cell lung cancers;
SU5416  (a  Flk-1/KDR   angiogenesis   inhibitor)  is  now  entering  Phase  III
registrational  studies for the treatment of non-small  cell lung and colorectal
cancer and will be entering Phase II/III in Kaposi's sarcoma.  A third compound,
SU6668,  (a novel broad spectrum  inhibitor of angiogenesis and tumor growth) is
in Phase I for the  treatment  of solid  tumor  cancers.  The  Company has major
research and development  collaborations with Zeneca, ASTA Medica,  Allergan and
Taiho.

Additional  written  materials and press releases  regarding SUGEN are available
through the SUGEN FAX-On-Demand Information Service by dialing 1-888-329-4699 or
at www.sugen.com.







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