SUGEN INC
SC 13D/A, 1999-06-16
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549

                            ------------------------

                                  SCHEDULE 13D
                    Under the Securities Exchange Act of 1934
                                (Amendment No. 2)

                                   SUGEN, INC.
                                (Name of Issuer)

                            SUGEN, INC. COMMON STOCK
                         (Title of Class of Securities)

                            ------------------------

                                    865041107
                                 (Cusip Number)

                                 Glen Engelmann
                                   Zeneca Inc.
                                1800 Concord Pike
                              Wilmington, DE 19897
                               Tel. (302) 886-3000
                     (Name, Address and Telephone Number of
                      Person Authorized to Receive Notices
                               and Communications)

                                  June 15, 1999
             (Date of Event which Requires Filing of this Statement)

                            ------------------------

      If the filing person has previously filed a statement on Schedule 13G to
report the acquisition that is the subject of this Schedule 13D, and is filing
this schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the
following box: [ ]

================================================================================


<PAGE>

                                  SCHEDULE 13D

CUSIP No. 865041107                                     Page 2 of 8 Pages

    1    NAME OF REPORTING PERSON

         S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         Zeneca Limited           51-0353514


    2    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                         (a) [ ]
                                                                         (b) [x]

    3    SEC USE ONLY

    4    SOURCE OF FUNDS*

         WC

    5    CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) or 2(e)                                                  [ ]

         Not Applicable

    6    CITIZENSHIP OR PLACE OF ORGANIZATION

         United Kingdom

                                        7    SOLE VOTING POWER

                                             3,036,016

                                        8    SHARED VOTING POWER

             NUMBER OF SHARES                0
        BENEFICIALLY OWNED BY EACH
           REPORTING PERSON WITH        9    SOLE DISPOSITIVE POWER

                                             3,036,016

                                        10   SHARED DISPOSITIVE POWER

                                             0

   11    AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         3,036,016


   12    CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN
         SHARES*                                                             [ ]

   13    PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         18.0%

   14    TYPE OF REPORTING PERSON*

         CO


                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>


      Zeneca Limited, an English corporation ("Zeneca"), hereby amends and
supplements its Report on Schedule 13D, originally filed on October 21, 1994 (as
amended by Amendment No. 1 thereto filed on January 20, 1995, the "Schedule
13D") with respect to the purchase of shares of Common Stock (the "Common
Stock") of Sugen Inc. (the "Issuer"). Unless otherwise indicated, each
capitalized term used but not defined herein shall have the meaning assigned to
such term in the Schedule 13D.

      This Amendment No. 2 to the Schedule 13D is filed in accordance with Rule
13d-2 of the Securities Exchange Act of 1934, as amended (the "Exchange Act"),
by Zeneca. Pursuant to Rule 13d-2(c) of the Exchange Act, this Amendment No. 2
amends and restates the text of the entire Schedule 13D (other than the
previously filed paper exhibits).

     Item 1.  Security and Issuer.

      The title of the class of equity securities to which this statement
relates is "Sugen, Inc. Common Stock". The issuer of the securities is Sugen,
Inc. with principal executive offices at 230 East Grand Avenue, South San
Francisco, California 94080.

     Item 2.  Identity and Background.

      The person filing this statement is Zeneca, whose principal business and
office address is 15 Stanhope Gate, London, England W1Y 6LN. The ultimate parent
corporation of Zeneca is AstraZeneca PLC, an English corporation formerly known
as Zeneca Group PLC ("AstraZeneca"), with the same principal business and office
address. Each of Zeneca and AstraZeneca is principally engaged in the business
of research, development, manufacture and marketing of pharmaceuticals,
agricultural chemicals and specialty chemicals. The names, addresses,
occupations and citizenship of the executive officers and directors of each of
Zeneca and AstraZeneca are set forth on Annex A hereto.

      Neither Zeneca nor AstraZeneca, nor to the best of Zeneca's knowledge, any
of their respective executive officers and directors listed on Annex A hereto
has, during the past five years, been convicted in a criminal proceeding
(excluding traffic violations or similar misdemeanors) or been a party to a
civil proceeding of a judicial or administrative body of competent jurisdiction
and as a result of such proceeding was or is subject to a judgment, decree or
final order enjoining future violations of, or prohibiting or mandating
activities subject to, Federal or State securities laws or finding any violation
with respect to such laws.

     Item 3.  Source and Amount of Funds or other Consideration.

      The source of all funds used in purchasing the securities was the cash
resources of Zeneca.

     Item 4.  Purpose of Transaction.

      The acquisition of the securities was made for investment purposes. Except
as described below, there are no plans or proposals of Zeneca, AstraZeneca or
any other person listed on Annex A hereto which relate to or would result in any
of the actions identified in Item 4 (a) through (j).

      The Voting Agreement dated as of June 15, 1999 (the "Voting Agreement")
among Pharmacia & Upjohn, Inc. ("Parent"), Zeneca and the other stockholder set
forth on the signature page thereto was executed in connection with the
Agreement and Plan of Merger dated as of June 15, 1999 (the "Merger Agreement")
among the Issuer, Parent and a wholly owned subsidiary of Parent ("Merger Sub"),
which contemplates the merger of Merger Sub with and into the Issuer (the
"Merger"). Pursuant to the terms of the Voting Agreement, Zeneca has agreed to
vote for the Merger. Upon the consummation of the Merger, all Common Stock
(including shares owned by Zeneca) will be exchanged for shares of Parent and
the Issuer will become a wholly owned subsidiary of Parent.

                                   Page 3 of 8


<PAGE>



     Item 5.  Interest in Securities of the Issuer.

      (a) - (b)Zeneca beneficially owns an aggregate of 3,036,016 shares of
Common Stock representing 18.0% of the outstanding Common Stock based on the
Issuer's most recent filing with the Commission. To the best of Zeneca's
knowledge, none of the other persons named in Item 2 is the beneficial owner of
any shares of Common Stock, except to the extent that any such person may be
deemed to be the beneficial owner of the shares of Common Stock owned by Zeneca.

      (c) Neither Zeneca nor, to the best of Zeneca's knowledge, any of the
persons named in response to Item 2 or listed on Annex A, has effected any
transaction in Common Stock during the 60 days prior to the date hereof.

      (d) - (e)Not Applicable.

      Item 6.  Contracts, Arrangements, Understandings or Relationships with
Respect to Securities of the Issuer.

      The acquisition and disposition of shares of Common Stock by Zeneca and
its affiliates is restricted in certain respects by the standstill and lockup
covenants set forth in the Stock Purchase Agreement between Zeneca and the
Issuer dated as of January 6, 1995, a copy of which was previously filed with
Amendment No. 1 to Schedule 13D.

       Pursuant to the Voting Agreement, Zeneca has agreed (i) to vote all
shares of Common Stock owned by it in favor of the adoption of the Merger
Agreement and the consummation of the Merger and related transactions (and to
deliver to Parent a proxy with respect thereto), (ii) not to enter into certain
voting arrangements with respect to Common Stock (other than the Voting
Agreement) and (iii) not to take certain actions that would impede or interfere
with the Merger or that would encourage or solicit acquisition proposals by any
person other than Parent or Merger Sub. For the full text of the Voting
Agreement, see Exhibit 2 attached hereto and incorporated by reference.

     Item 7.  Exhibits.

      The following exhibit is incorporated by reference from Amendment No. 1 to
Schedule 13D filed on January 20, 1995:

      Exhibit 1: Common Stock Purchase Agreement dated as of January 6, 1995.

      The following exhibit is attached hereto:

      Exhibit 2: Voting Agreement dated as of June 15, 1999 among Parent,
                 Zeneca and the other stockholder set forth on the signature
                 page thereto.



                                   Page 4 of 8


<PAGE>



                                   SIGNATURES

      After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                 June 16, 1999
                                 ------------------------------------
                                 (Date)



                                 /s/  G.H.R. Musker
                                 ------------------------------------
                                 (Signature)



                                 Group Secretary and Solicitor
                                 ------------------------------------
                                 (Name/Title)



                                   Page 5 of 8


<PAGE>


                                     ANNEX A

                        EXECUTIVE OFFICERS AND DIRECTORS

               The names of the Executive Officers and Directors of Zeneca and
AstraZeneca and their present principal occupations are set forth below.
Unless otherwise indicated, each individual is a British citizen and the
business address of each person is 15 Stanhope Gate, London, W1Y 6LN, England.


<TABLE>
<S>                                        <C>
           Name                                   Principal Occupations and Business Address
- -----------------------------------------  ---------------------------------------------------------
Percy Barnevik (Swedish citizen)           Non-Executive Chairman of AstraZeneca; Chairman of
 ABB Limited                               Investor AB; ABB Asea Brown Boveri and Sandvik AB;
 PO Box 8131                               Director of General Motors
 CH-8050 Zurich
 Switzerland

Sir David Barnes                           Executive Deputy Chairman of AstraZeneca; Director of
                                           Zeneca; Non-Executive Director of Prudential Corporation
                                           Plc; Deputy Chairman of Business in the Community;
                                           Member of the Board of Trustees of the British Red Cross

Hakan Mogren (Swedish citizen)             Executive Deputy Chairman of AstraZeneca; Chairman of
                                           the Research Institute of Industrial Economics; Vice
                                           Chairman of the Social and Economic Council; Director of
                                           Investor AB, Incentive AB, the Federation of Swedish
                                           Industries, and the Carl Trygger Foundation

Tom McKillop                               Chief Executive of AstraZeneca; Director of Zeneca; Non-
                                           Executive Director of Nycomed Amersham plc; Non-
                                           Executive Director of Lloyds TSB Group plc

Ake Stavling (Swedish citizen)             Executive Director, Business Development & Integration of
                                           AstraZeneca

Jonathan Symonds                           Executive Director, Chief Financial Officer of AstraZeneca;
                                           Director of Zeneca

Claes Wilhelmsson (Swedish citizen)        Executive Director, Research & Development of
 AstraZeneca Plc                           AstraZeneca
 S-151 85 Sodertalje
 Sweden

Michael Pragnell                           Executive Director, Agrochemicals of AstraZeneca; Director
 Zeneca Agrochemicals                      of Zeneca; Non-Executive Director of David S Smith
 Fernhurst                                 (Holdings) PLC
 Haslemere
 Surrey GU27 3JE
 United Kingdom

Erna Moller (Swedish citizen)              Non-Executive Director of AstraZeneca; Member of the
 Huddinge Sjukhus                          Nobel Assembly, Karolinska Institute
 Avd. for Klinisk Immunologi
 S-141 86 Huddinge
 Sweden

                                   Page 6 of 8

<PAGE>


Lars Ramqvist (Swedish citizen)            Non-Executive Director of AstraZeneca; Chairman of L M
 c/o Skandia                               Ericsson; Director of SCA, Volvo AB, Skandia AB, EQT
 S44-62                                    Scandinavia II and the Federation of Swedish Industries
 S-103 50 Stockholm
 Sweden

Marcus Wallenberg (Swedish citizen)        Non-Executive Director of AstraZeneca; President and Chief
 Investor AB                               Executive officer of Investor AB; Vice Chairman of L M
 S-103 32 Stockholm                        Ericsson and Saab AB
 Sweden

Sir Peter Bonfield                         Non-Executive Director of AstraZeneca; Chief Executive of
 British Telecommunications PLC            British Telecommunications PLC; Non-Executive Deputy
 BT Centre                                 Chairman of ICL plc; Vice President of the British Quality
 81 Newgate Street                         Foundation
 London EC1A 7AJ
 United Kingdom

Karl von der Heyden (U.S. citizen)         Non-Executive Director of AstraZeneca; Vice Chairman,
 PepsiCo Inc.                              PepsiCo Inc.; Non-Executive Director of Federated
 700 Anderston Hill Road                   Department Stores Inc.
 Purchase, NY 10577-1444
 USA

Dame Bridget Ogilvie (Australian citizen)  Non-Executive Director of AstraZeneca; Non-Executive
 University College London                 Director of Lloyds TSB Group plc
 Gower Street
 London WC1E 6BT
 United Kingdom

Carl-Gustaf Johansson (Swedish citizen)    Executive officer, North America of AstraZeneca
 Astra Pharmaceuticals LP
 725 Chesterbrook Blvd.
 Wayne, PA 19087-5677
 USA

Michael O'Brien                            Executive officer, Europe and RoW of AstraZeneca
 AstraZeneca Plc
 Alderley House
 Alderley Park
 Macclesfield
 Cheshire   SK10 4TF
 United Kingdom

John Patterson                             Executive officer, Product Strategy and Licensing of
 AstraZeneca Plc                           AstraZeneca
 S-151 85 Sodertalje
 Sweden


                                   Page 7 of 8


<PAGE>


Barrie Thorpe                              Executive officer, Operations of AstraZeneca
 AstraZeneca Plc
 Alderley House
 Alderley Park
 Macclesfield
 Cheshire   SK10 4TF
 United Kingdom

Gunnar Christiani (Swedish citizen)        Executive officer, Human Resources of AstraZeneca
 Astra Management Resources AG
 Kanalstrasse 6, GH-8955 Dietikon
 Switzerland

Graeme Musker                              Secretary of AstraZeneca and Zeneca

                                   Page 8 of 8

</TABLE>



                                VOTING AGREEMENT

                  VOTING AGREEMENT, dated as of June 15, 1999 (this
"Agreement"), among Pharmacia & Upjohn, Inc., a Delaware corporation ("Parent"),
and the individuals and entities whose names and addresses are set forth on the
signature pages hereto (collectively, the "Stockholders", and each,
individually, a "Stockholder").

                  WHEREAS, contemporaneously with the execution and delivery of
this Agreement, Parent and its wholly owned subsidiary, University Acquisition
Corp., a Delaware corporation ("Merger Sub"), have executed and delivered an
Agreement and Plan of Merger, dated as of the date hereof (the "Merger
Agreement"), a copy of which is annexed hereto as Annex A, with SUGEN, Inc., a
Delaware corporation (the "Company"), which provides, among other things, that
Merger Sub will merge with and into the Company pursuant to the merger
contemplated by the Merger Agreement (the "Merger"); and

                  WHEREAS, as of the date hereof, each Stockholder holds of
record and beneficially owns the number of shares of common stock, par value
$0.01 per share, of the Company (the "Company Common Stock") set forth opposite
his or its name on the signature pages hereto; and

                  WHEREAS, contemporaneously with the execution and delivery of
this Agreement, each Stockholder has executed and delivered to Parent a letter
agreement in substantially the form of Exhibit AZ-1 or A-1 to the Merger
Agreement; and

                  WHEREAS, Parent wishes each Stockholder to enter into this
Agreement governing the voting of all of the shares of Company Common Stock that
are now held of record or beneficially owned by such Stockholder (collectively,
the "Shares"); and all of the New Shares (as defined in Section 6) held or owned
by such Stockholder.

                  NOW, THEREFORE, in consideration of the premises, and of the
representations, warranties, and covenants and agreements contained herein, the
parties hereto hereby agree as follows:

                  1. Definitions. Capitalized terms used herein but not defined
herein have the respective meanings ascribed to such terms in the Merger
Agreement.



<PAGE>




                  2. Agreement to Vote Shares. During the term of this
Agreement, each Stockholder agrees that it consents to, approves, authorizes and
directs the voting of all Shares and any New Shares held or owned by such
Stockholder, and agrees to cause all Shares and any New Shares held or owned by
such Stockholder to be voted, at every meeting of the stockholders of the
Company at which such matters are con sidered and at every adjournment thereof
or in connection with any written consent of the stockholders of the Company
related to such matters, in favor of the adoption of the Merger Agreement and
the consummation of the Merger and the other transactions contemplated by the
Merger Agreement (collectively, the "Merger Transactions"). Each Stockholder
agrees to deliver to Parent promptly upon the request therefor a proxy in the
form attached hereto as Exhibit A, which proxy is coupled with an interest and
shall be irrevocable during the term of this Agreement to the fullest extent
permitted under Delaware law. The proxy granted by each Stockholder shall be
revoked upon the termination of this Agreement in accordance with its terms.

                  3. No Voting Trusts or Agreements. Each Stockholder agrees
that it will not, and will not permit any entity under its control to, deposit
any of the Shares or New Shares held or owned by such Stockholder in any voting
trust, grant any proxies or powers of attorney with respect to such Shares or
New Shares or, except as contemplated by this Agreement, subject any such Shares
or New Shares to any agreement, instrument or arrangement with respect to the
voting of such Shares or New Shares other than this Agreement.

                  4. No Proxy Solicitations. Each Stockholder agrees that it
will not, and will not permit any entity under its control to, (a) solicit
proxies in opposition to the consummation of the Merger Transactions or
otherwise knowingly encourage or assist any party in taking or planning any
action which would impede, interfere with or attempt to discourage the Merger
Transactions or inhibit the timely consummation of the Merger Transactions, (b)
directly or indirectly knowingly encourage, initiate or cooperate in a
stockholders' vote or action by consent of the Company's stockholders in
opposition to the consummation of the Merger Transactions, or (c) become a
member of a "group" (as such term is used in Section 13(d) of the Exchange Act)
with respect to any voting securities of the Company for the

                                       -2-



<PAGE>



purpose of opposing the consummation of the Merger Transactions.

                  5. No Additional Purchases or Acquisitions. Each Stockholder
agrees that any shares of Common Stock or other capital stock of the Company of
which such Stockholder becomes the record holder or acquires beneficial
ownership following the execution and delivery of this Agreement ("New Shares")
acquired or purchased by it shall be subject to the terms of this Agreement to
the same extent as if they constituted Shares held or owned by such Stockholder
on the date of this Agreement.

                  6. Additional Shares. Each Stockholder agrees, while this
Agreement is in effect, to promptly notify Parent of the number of any New
Shares acquired by such Stockholder, if any, after the date hereof. In the event
that, between the date of this Agreement and the Closing, the Shares held or
owned by any Stockholder shall have been affected or changed into a different
number of shares or a different class of shares as a result of a share split,
reverse share split, share distribution, spin-off, recapitalization,
reclassification (other than a change in par value), or other similar
transaction, the term "Shares" shall be deemed to refer to and include the
Shares as well as any securities into which or for which any or all of the
Shares may be converted or exchanged and all such share distributions or, if
applicable, to such smaller number of securities replacing the Shares.

                  7. Non-Interference. Each Stockholder agrees not to knowingly
take any action that would make any representation or warranty of such
Stockholder contained herein untrue or incorrect or have the effect of
preventing or disabling any Stockholder from performing its obligations under
this Agreement.

                  8. Acquisition Proposals. Each Stockholder shall, and shall
use its commercially reasonable efforts to cause its affiliates and its and
their respective officers, directors, employees and representatives to,
immediately cease and terminate any existing activities, discussions or
negotiations, if any, with any parties conducted heretofore with respect to any
acquisition or exchange of all or any material portion of such Stockholder's
Shares (an "Acquisition Transaction"), other than the Merger. In its capacity as
a stockholder of the Company, each Stockholder

                                       -3-



<PAGE>



shall not, and shall use its commercially reasonable efforts to cause its
affiliates and its and their respective officers, directors, employees and
representatives not to, directly or indirectly, knowingly encourage, solicit,
participate in or initiate discussions or negotiations with, or provide any
information or data (other than the Company's standard public information
package) to, or have any discussions with, any corporation, partnership, person
or other entity or group (other than Parent and Merger Sub, any affiliate or
associate of Parent and Merger Sub or any designees of Parent and Merger Sub)
with respect to any inquiries or the making of any offer or proposal (including,
without limitation, any offer or proposal to the stockholders of the Company)
concerning an Acquisition Transaction (an "Acquisition Proposal") or otherwise
facilitate any effort or attempt to make or implement an Acquisition Proposal.

                  9. Representations and Warranties of the Stockholders. Each
Stockholder hereby severally represents and warrants to Parent as follows:

                  (a) Authority Relative to this Agreement. Such Stockholder has
all necessary power and authority to execute and deliver this Agreement, to
perform its obligations hereunder and to consummate the transactions
contemplated hereby. The execution and delivery of this Agreement by such
Stockholder and the consummation by such Stockholder of the transactions
contemplated hereby have been duly and validly authorized by all necessary
action on the part of the Stockholder. This Agreement has been duly and validly
executed and delivered by such Stockholder and constitutes a legal, valid and
binding obligation of such Stockholder, enforceable in accordance with its
terms.

                  (b) No Conflict. The execution and delivery of this Agreement
by such Stockholder does not, and the performance of this Agreement by such
Stockholder will not, (i) require any consent, approval, authorization or permit
of, or filing with or notification to (other than pursuant to the Exchange Act
and the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended), any
governmental or regulatory authority, domestic or foreign by or with respect to
such Stockholder, (ii) if applicable, conflict with or violate the memorandum of
association and articles of association or other organizational documents of
such Stockholder, (iii) conflict with or violate any law, rule,

                                       -4-



<PAGE>



regulation, order, judgment or decree applicable to such Stockholder or by which
such Stockholder's Shares or New Shares are bound, or (iv) result in any breach
of or constitute a default (or any event which with notice or lapse of time or
both would become a default) under, or give to others any right of termination,
amendment, acceleration or cancellation of, or result in the creation of a lien
or other encumbrance of any nature whatsoever on such Stockholder's Shares or
New Shares pursuant to, any note, bond, mortgage, indenture, contract,
agreement, lease, license, permit, franchise or other instrument or obligation
to which such Stockholder is a party or by which such Stockholder or such
Stockholder's Shares or New Shares may be bound, except, in the case of clauses
(iii) and (iv), for any such conflicts, violations, breaches, defaults or other
occurrences which would not prevent or materially delay the performance by such
Stockholder of its obligations hereunder.

                  (c) Title to the Shares. As of the date of this Agreement,
such Stockholder does not beneficially own any shares of capital stock of the
Company other than the number of Shares set forth opposite such Stockholder's
name on one of the signature pages hereto and does not have any options,
warrants or other rights to acquire any additional shares of capital stock of
the Company or any security exercisable for or convertible into shares of
capital stock of the Company, other than as set forth in a written schedule
referring to this Section 12(c) delivered by such Stockholder to Parent prior to
the date of this Agreement. Except as disclosed in any Schedule 13D filed by the
Stockholder with respect to its Shares prior to the date of this Agreement and
except pursuant to margin agreements between the Stockholder and any
broker-dealer, such Stockholder owns all such Shares free and clear of all
security interests, liens, claims, pledges, options, rights of first refusal,
agreements, limitations on such Stockholder's voting rights, charges, security
interests and other encumbrances of any nature whatsoever, and, except as
provided in this Agreement, such Stockholder has not appointed or granted any
proxy, which appointment or grant is still effective, with respect to the
Shares. Except as disclosed in any Schedule 13D filed by the Stockholder with
respect to its Shares prior to the date of this Agreement and except for
agreements providing registration rights with respect to the Shares and except
pursuant to margin agreements between the Stockholder and any broker-dealer,
there are no agreements, arrangements or

                                       -5-



<PAGE>



commitments of any character to which such Stockholder is a party relating to
the pledge or disposition of any Shares or any other shares of capital stock of
the Company and, except for this Agreement, there are no voting trusts or voting
agreements to which such Stockholder is a party with respect to any shares of
capital stock of the Company.

                  10. Representations, Warranties and Covenants of Parent.
Parent hereby represents and warrants to the Stockholders that Parent has all
necessary power and authority to execute and deliver this Agreement and the
Merger Agreement and to perform its obligations hereunder and thereunder, and to
consummate the transactions contemplated hereby and thereby. The execution,
delivery and performance of this Agreement and the Merger Agreement by Parent
have been duly authorized by all necessary corporate action on the part of
Parent. This Agreement and the Merger Agreement have each been duly and validly
executed and delivered by Parent and each constitutes a legal, valid and binding
obligation of Parent enforceable in accordance with its terms. The Merger
Agreement annexed hereto as Exhibit A is in the form executed by Parent and the
other parties thereto. Parent agrees to use commercially reasonable efforts to
take, or cause to be taken, all action, and to do, or cause to be done, all
things necessary, proper or advisable under applicable laws and regulations to
publicly release a report covering at least 30 days of combined operations of
Parent and the Company after the consummation of the Merger, at the earliest
date reasonably practicable. Parent agrees to use its commercially reasonable
efforts to take or cause to be taken all actions, and do or cause to be done all
things, necessary, proper or advisable under the Merger Agreement and applicable
laws to consummate and make effective the Merger and the other transactions
contemplated by the Merger Agreement as soon as practicable, including preparing
and filing as promptly as practicable all documentation to effect all necessary
applications, notices, petitions, filings and other documents and to obtain as
promptly as practicable all permits, consents, approvals and authorizations
necessary or advisable to be obtained from any third party and/or any
governmental entity in order to consummate the Merger or any of the other
transactions contemplated by the Merger Agreement.

                  11. Further Assurances. From time to time, at the other
party's request and without further consideration,

                                       -6-



<PAGE>



each party hereto shall execute and deliver, or cause to be executed and
delivered, such additional consents, documents and other instruments and take
all such further action as may be necessary or desirable to consummate and make
effective, in the most expeditious manner practicable, the Merger Transactions
and the other transactions contemplated by this Agreement.

                  12. Termination. This Agreement shall terminate upon the
earliest to occur of (i) the termination of the Merger Agreement, (ii) the
Effective Time (as defined in the Merger Agreement) and (iii) the first
anniversary of the date of this Agreement.

                  13. Assignment; Third Party Beneficiaries. This Agreement and
all of the provisions hereof shall be binding and inure to the benefit of the
parties hereto and their respective successors and permitted assigns, but
neither this Agreement nor any of the rights, interests and obligations
hereunder shall be assigned by any of the parties hereto without the prior
written consent of the other parties. Any purported assignment made in violation
of this Agreement shall be null and void. This Agreement is not intended to
confer any rights or remedies hereunder upon any other Person except the parties
hereto.

                  14. Modification or Amendment. Subject to the provisions of
the applicable law, the parties hereto may modify or amend this Agreement, by
written agreement executed and delivered by duly authorized officers of the
respective parties.

                  15. Waiver of Conditions. The conditions to each of the
parties' obligations to consummate the Merger are for the sole benefit of such
party and may be waived by such party in whole or in part to the extent
permitted by applicable law.

                  16. Counterparts. This Agreement may be executed in any number
of counterparts, each such counterpart being deemed to be an original
instrument, and all such counterparts shall together constitute the same
agreement.

                  17. GOVERNING LAW AND VENUE; WAIVER OF JURY TRIAL. (a) THIS
AGREEMENT SHALL BE DEEMED TO BE MADE IN AND IN ALL RESPECTS SHALL BE
INTERPRETED, CONSTRUED AND GOVERNED BY AND IN ACCORDANCE WITH THE LAWS OF THE
STATE OF

                                       -7-



<PAGE>



NEW YORK WITHOUT REGARD TO THE CONFLICT OF LAW PRINCIPLES THEREOF. The parties
hereby irrevocably submit to the jurisdiction of the courts of the State of New
York and the Federal courts of the United States of America located in the
Borough of Manhattan, The City of New York solely in respect of the
interpretation and enforcement of the provisions of this Agreement and of the
proxies referred to in Section 2 and in respect of the transactions contemplated
hereby and thereby, and hereby waive, and agree not to assert, as a defense in
any action, suit or proceeding for the interpretation or enforcement hereof or
of any such document, that it is not subject thereto or that such action, suit
or proceeding may not be brought or is not maintainable in said courts or that
the venue thereof may not be appropriate or that this Agreement or any such
proxy may not be enforced in or by such courts, and the parties hereto
irrevocably agree that all claims with respect to such action or proceeding
shall be heard and determined in such a New York State or Federal court. The
parties hereby consent to and grant any such court jurisdiction over the person
of such parties and over the subject matter of such dispute and agree that
mailing of process or other papers in connection with any such action or
proceeding in the manner provided in Section 18 or in such other manner as may
be permitted by law, shall be valid and sufficient service thereof.

                  (b) EACH PARTY ACKNOWLEDGES AND AGREES THAT ANY CONTROVERSY
WHICH MAY ARISE UNDER THIS AGREEMENT OR THE PROXIES REFERRED TO IN SECTION 2 IS
LIKELY TO INVOLVE COMPLICATED AND DIFFICULT ISSUES, AND THEREFORE EACH SUCH
PARTY HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES ANY RIGHT SUCH PARTY MAY
HAVE TO A TRIAL BY JURY IN RESPECT OF ANY LITIGATION ARISING DIRECTLY OR
INDIRECTLY OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED
HEREBY OR THEREBY. EACH PARTY CERTIFIES AND ACKNOWLEDGES THAT (I) NO
REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY
OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK
TO ENFORCE THE FOREGOING WAIVER, (II) EACH SUCH PARTY UNDERSTANDS AND HAS
CONSIDERED THE IMPLICATIONS OF THIS WAIVER, (III) EACH SUCH PARTY MAKES THIS
WAIVER VOLUNTARILY, AND (IV) EACH SUCH PARTY HAS BEEN INDUCED TO ENTER INTO THIS
AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS
SECTION 17.

                                       -8-



<PAGE>



                  18. Notices. Any notice, request, instruction or other
document to be given hereunder by any party to the others shall be in writing
and delivered personally or sent by registered or certified mail, postage
prepaid, or by facsimile:

                  if to Parent, to:

                  Richard T. Collier
                  Pharmacia & Upjohn, Inc.
                  95 Corporate Drive
                  Bridgewater, NJ 08807
                  fax:  (908) 306-4489

                  with copies to:
                  Neil T. Anderson
                  Matthew G. Hurd
                  and Martin J. Travers
                  Sullivan & Cromwell
                  125 Broad Street
                  New York, New York 10004
                  fax:  (212) 558-3588.

                  if to any Stockholder, to:
                  the individual and to the address set forth
                  opposite such Stockholder's name on one of the
                  signature pages of this Agreement.

or to such other persons or addresses as may be designated in writing by the
party to receive such notice as provided above.

                  19. Entire Agreement. This Agreement (including the proxies
granted pursuant hereto) constitutes the entire agreement, and supersedes all
other prior agreements, understandings, representations and warranties both
written and oral, among the parties, with respect to the subject matter hereof.

                  20. Severability. The provisions of this Agree ment shall be
deemed severable and the invalidity or unenforceability of any provision shall
not affect the validity or enforceability or the other provisions hereof. If any
provision of this Agreement, or the application thereof to any Person or any
circumstance, is invalid or unenforceable, (a) a suitable and equitable
provision shall be substituted therefor in order to carry out, so far as may

                                       -9-



<PAGE>



be valid and enforceable, the intent and purpose of such invalid or
unenforceable provision and (b) the remainder of this Agreement and the
application of such provision to other Persons or circumstances shall not be
affected by such invalidity or unenforceability, nor shall such invalidity or
unenforceability affect the validity or enforceability of such provision, or the
application thereof, in any other jurisdiction.

                  21. Specific Performance. The parties hereto each acknowledge
that, in view of the uniqueness of the subject matter hereof, the parties hereto
would not have an adequate remedy at law for money damages if this Agreement
were not performed in accordance with its terms, and therefore agree that the
parties hereto shall be entitled to specific enforcement of the terms hereof in
addition to any other remedy to which the parties hereto may be entitled at law
or in equity.

                  22. No Reference to Stockholders. Parent shall not make any
reference, directly or indirectly, to AstraZeneca plc or its affiliates or the
Company's relationship with AstraZeneca plc or its affiliates without the prior
consent of AstraZeneca plc.

                                      -10-


<PAGE>



                  IN WITNESS WHEREOF, this Agreement has been duly executed and
delivered by duly authorized officers of the parties hereto as of the date
hereof.

                                         PHARMACIA & UPJOHN, INC.




                                         By:
                                             -----------------------------------
                                             Name:
                                             Title:

                                      -11-


<PAGE>



                      (Signature Page to Voting Agreement)

Stockholder:                                          NUMBER OF SHARES OWNED

                                                              864,469

- ----------------------------
Name:  Stephen Evans-Freke
Address:  c/o SUGEN, Inc.
          230 East Grand Avenue
          South San Francisco, CA  94080

ZENECA LIMITED

                                                            3,036,016

By:
    ------------------------------
    Name:
    Title:
    Address:  Attention: Company Secretary of
              Zeneca Limited
              15 Stanhope Gate
              London W1Y 6LN
              United Kingdom
              fax: 44(171)304-5196

                                      -12-


<PAGE>


                                                                     (EXHIBIT A)

                                  FORM OF PROXY

                  The undersigned, for consideration received, hereby appoints o
and o and each of them [my][its] proxies, with power of substitution and
resubstitution, to vote all shares of Common Stock of SUGEN, Inc., a Delaware
corporation (the "Company"), [and [insert any New Shares (as defined in the
Voting Agreement) or other shares of capital stock of the Company owned by the
Stockholder (as defined in the Voting Agreement)]] owned by the undersigned at
the Special Meeting of Stockholders of the Company to be held [insert date, time
and place] and at any adjournment thereof IN FAVOR OF adoption of the Agreement
and Plan of Merger, dated as of June 15, 1999 (the "Merger Agreement"), among
the Company, Pharmacia & Upjohn, Inc. ("Parent") and University Acquisition
Corp. and IN FAVOR OF consummation of the Merger Transactions. This proxy is
coupled with an interest, revokes all prior proxies granted by the undersigned
and is irrevocable until such time as the Voting Agreement, dated as of June 15,
1999 among the undersigned, the Company and Parent terminates in accordance with
its terms. This proxy shall be revoked upon termination of such Voting
Agreement.

Dated o, 1999


                                            ------------------------------------
                                            [STOCKHOLDER]



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