OXIGENE INC
SC 13D/A, 1996-10-11
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  SCHEDULE 13D

                                 (RULE 13D-101)

Information  to be included in  statements  filed  pursuant to Rule 13d-1(a) and
amendments thereto filed pursuant to Rule 13d-2(a).

                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934
                               (Amendment No. 3 )

                                  Oxigene, Inc
- -------------------------------------------------------------------------------
                                (Name of Issuer)

                                  Common Stock
- -------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    691828107
- -------------------------------------------------------------------------------
                                 (CUSIP Number)

         Oxigene, Inc, 110 E.59th Street, New York 10022, United States
                              Phone #212 421 0001
- -------------------------------------------------------------------------------
                     (Name, Address, Telephone No of Person
                Authorised to Receive Notices & Communications)

                                 08 October 1996
- -------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of This Statement)

If the filing person has previously filed a statement on Schedule 13G to report
the acquisition which is the subject of this Schedule 13D, and is filing this
schedule because of Rule 13d-1(b) (3) or (4), check the following box [ ].

Check the following box if a fee is being paid with this statement [ ]. (A fee
is not required only if the reporting person: (1) has a previous statement on
file reporting beneficial ownership of more than five percent of the class of
securities described in Item 1; and (2) has filed no amendment subsequent
thereto reporting beneficial ownership of less than five percent of such class.
See Rule 13d-7).
<PAGE>

<TABLE>
<CAPTION>
CUSIP No.                                                                          691828107
- -------------------------------------------------------------------------------------------
<S>                                                                                <C>     

1)    Names of Reporting Persons/S. S. or I.R.S. Identification Nos. of Above 
      Persons Morgan Grenfell Asset Management Limited, [parent holding  
      company] on behalf of susbdiary companies: Morgan Grenfell International 
      Funds Management Limited

- --------------------------------------------------------------------------------------------

2)    Check the Appropriate Row if a Member of a Group
      (a) See 1) above
      (b) n/a

- --------------------------------------------------------------------------------------------

3)    SEC Use Only _________________________________________________________________________

- --------------------------------------------------------------------------------------------

4)    Source of Funds                 OO - Discretionary Funds under Management

- --------------------------------------------------------------------------------------------

5)    Check if Disclosure of Legal Porceedings is Required Pursuant to Item 2(d)
      or 2(e) n/a

- --------------------------------------------------------------------------------------------

6)    Place of Organisation                                                          England
- --------------------------------------------------------------------------------------------

      Number of            (7) Sole Voting Power                                     516,600
      Shares      Bene-
      ficially Owned by    (8) Shared Voting Power                                   n/a
      Each
      Reporting            (9) Sole Dispositive Power                                538,000
      Person With
                           (10) Shared Dispositive Power                             n/a

- --------------------------------------------------------------------------------------------

11)   Aggregate Amount Beneficially Owned by Each 
      Reporting Person

      Morgan Grenfell Investment Management Limited [ineligible institution]         538,000
      Aggregated holding                                                             538,000

- --------------------------------------------------------------------------------------------

12)   Check if the Aggregate Amount in Row (11) Excludes Certain Shares                n/a

- --------------------------------------------------------------------------------------------

13)   Percent of Class Represented by Amount in Row (11)
      Morgan Grenfell Investment Management Limited                                     7.40
      Aggregated                                                                        7.40

- --------------------------------------------------------------------------------------------

14) Type of Reporting Person                                                     HC [of IAs]

- --------------------------------------------------------------------------------------------
</TABLE>

<PAGE>

                                    SIGNATURE

After  reasonable  inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.



                                                                 09 October 1996
                                       -----------------------------------------
                                                                          (Date)
        

                                              /s/ LB Hacking
                                       -----------------------------------------
                                                                     (Signature)



                                                  LB Hacking, Compliance Officer
                                       -----------------------------------------
                                                                (Name and Title)


The  original  statement  shall be signed by each  person  on whose  behalf  the
statement is filed or his authorised representative.  If the statement is signed
on behalf of a person by his authorised  representative (other than an executive
officer  or  general   partner  of  this   filing   person),   evidence  of  the
representative's  authority to sign on behalf of such person shall be field with
the  statement;  provided,  however,  that a power of attorney  for this purpose
which is already on file with the Commission may be  incorporated  by reference.
The name and any title of each person who signs the statement  shall be typed or
printed beneath his signature.


            ATTENTION: INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT
          CONSTITUTE FEDERAL CRIMINAL VIOLATIONS (SEE 18 U.S.C. 1001).


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