OXIGENE INC
NT 10-K, 1998-04-01
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                            March 31, 1998



VIA EDGAR
- ---------

Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, D.C.  20549


          Re:  OXiGENE, Inc. - Form 12b-25,  Notification of Late Filing of Form
               10-K for the period ended December 31, 1997
               -----------------------------------------------------------------

Ladies and Gentlemen:

     On behalf of OXiGENE,  Inc. (the "Company"),  we hereby file Form 12b-25 in
order to extend the time for filing of the Company's  Annual Report on Form 10-K
for the period ended December 31, 1997.

     Simultaneously  with this  filing,  we also are sending a copy of this Form
12b-25 to The Nasdaq Stock Market, Inc.

     Please  telephone  the  undersigned  at  (212)  504-6804  if you  have  any
questions or comments.

                                                      Very truly yours,


                                                        /s/ M. Andica Kunst
                                                      --------------------------
                                                      M. Andica Kunst


cc:      OXiGENE, Inc.
         The Nasdaq Stock Market, Inc.




                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549


                                   FORM 12b-25
                           NOTIFICATION OF LATE FILING


- ----------------------------
OMB APPROVAL
OMB Number:  3235-0058
Expires:     May 31, 1997
Estimated average burden
hours per response.....2.50
- ----------------------------


- -----------------
SEC FILE NUMBER
0-21990
- -----------------


- -----------------
CUSIP NUMBER
691828-10-7
- -----------------



(Check One): /X/Form 10-K  /_/Form 20-F /_/Form 11-K /_/Form 10-Q /_/Form N-SAR

          For Period Ended: December 31, 1997 
          [ ] Transition Report on Form 10-K 
          [ ] Transition  Report on Form 20-F 
          [ ] Transition Report on Form 11-K 
          [ ] Transition  Report on Form 10-Q 
          [ ] Transition  Report on Form N-SAR 
          For the  Transition  Period Ended:------------------------------------



- --------------------------------------------------------------------------------
 Read Attached Instruction Sheet Before Preparing Form. Please Print or Type.

          Nothing  in this form shall be  construed  to imply that the
          Commission has verified any  information  contained  herein.

- --------------------------------------------------------------------------------

If the notification  relates to a portion of the filing checked above,  identify
the Item(s) to which the notification relates:


- --------------------------------------------------------------------------------

PART I -- REGISTRANT INFORMATION


     OXiGENE, Inc.
- --------------------------------------------------------------------------------
Full Name of Registrant


- --------------------------------------------------------------------------------
Former Name if Applicable


One Copley Place, Suite 602
- --------------------------------------------------------------------------------
Address of Principal Executive Office (Street and Number)


Boston, MA 02116
- --------------------------------------------------------------------------------
City, State and Zip Code



PART II -- RULES 12b-25(b) AND (c)

If the subject report could not be filed without  unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be completed. (Check box if appropriate)

               (a)  the reasons described in reasonable detail in Part
                    III of this form could not be  eliminated  without
                    unreasonable effort or expense;


               (b)  The subject  annual  report,  semi-annual  report,
                    transition report on From 10-K, Form 20-F, 11-K or
                    Form N-SAR, or portion  thereof,  will be filed on
/X/                 or before the fifteenth calendar day following the
                    prescribed  due  date;  or the  subject  quarterly
                    report  of  transition  report  on Form  10-Q,  or
                    portion  thereof  will be filed on or  before  the
                    fifth  calendar day following the  prescribed  due
                    date; and


               (c)  The   accountant's   statement  or  other  exhibit
                    required by Rule  12b-25(c)  has been  attached if
                    applicable.

PART III -- NARRATIVE

State below in  reasonable  detail the  reasons  why Form 10-K and Form  10-KSB,
20-F,  11-K,  10-Q Form  10-QSB,  N-SAR,  or the  transition  report or  portion
thereof, could not be filed within the prescribed time period.

     All information necessary to complete the filing has not yet been compiled.


                                                 (Attach Extra Sheets if Needed)
                                                                SEC  1344 (6/94)


PART IV -- OTHER INFORMATION

(1)  Name  and  telephone  number  of  person  to  contact  in  regard  to  this
     notification


          Gerald A. Eppner                 (212)                  504-6286
     ----------------------------     ---------------       --------------------
               (Name)                   (Area Code)          (Telephone Number)



(2)  Have all other periodic  reports  required under Section 13 or 15(d) of the
     Securities Exchange Act of 1934 or Section 30 of the Investment Company Act
     of 1940 during the preceding 12 months or for such shorter  period that the
     registrant was required to file such report(s) been filed? If answer is no,
     identify report(s). 

     /X/ Yes        /_/ No




(3)  Is it anticipated that any significant change in results of operations from
     the corresponding  period for the last fiscal year will be reflected by the
     earnings  statements  to be  included  in the  subject  report  or  portion
     thereof? 

     /_/ Yes        /X/ No

     If so, attach an explanation of the anticipated  change,  both  narratively
     and quantitatively, and, if appropriate, state the reasons why a reasonable
     estimate of the results cannot be made.















- --------------------------------------------------------------------------------





                                  OXiGENE, Inc.
       -----------------------------------------------------------------
                  (Name of Registrant as Specified in Charter)


has  caused  this  notification  to be signed on its  behalf by the  undersigned
hereunto duly authorized.


Date    March 27, 1998                         By    /s/ Bo A. Haglund
      ---------------------------------------    -------------------------------
                                                 Title:  Chief Financial Officer




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