OXIGENE INC
10-K/A, 1998-04-17
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                 FORM 10-K/A-1

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

- --------------------------------------------------------------------------------

                  Annual Report Pursuant to Section 13 or 15(d)
                     of the Securities Exchange Act of 1934


                   For the fiscal year ended December 31, 1997
                           Commission File No. 0-21990


                                  OXiGENE, INC.
             (Exact name of registrant as specified in its charter)
- --------------------------------------------------------------------------------


           Delaware                                         13-3679168
- ---------------------------------                -------------------------------
(State or other jurisdiction of                  (I.R.S. employer identification
incorporation or organization)                               number)

                  One Copley Place, Suite 602, Boston, MA 02116
                    (Address of principal executive offices)

                                 (617) 536-9500
                     (Telephone number, including area code)


Securities registered pursuant to Section 12(b) of the Act:  None


Securities registered pursuant to Section 12(g) of the Act:


                     Common Stock, par value $.01 per share
                  Warrant to purchase one share of Common Stock
                               Title of Each Class


Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days.   Yes X    No __

Indicate by check mark if disclosure of delinquent  filers  pursuant to Item 405
of Regulation  S-K is not contained  herein,  and will not be contained,  to the
best of registrant's  knowledge,  in definitive proxy or information  statements
incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K. [ X ]

The   approximate   aggregate   market   value  of  the  voting  stock  held  by
non-affiliates of the registrant as of March 19, 1998 was $160,791,403, based on
the closing price of $17.125 on that date.

As of March 19, 1998, the aggregate number of outstanding shares of Common Stock
of the registrant was 10,195,765 shares.

                       DOCUMENTS INCORPORATED BY REFERENCE

The  registrant's  Proxy  Statement  for the  Annual  Meeting  of  Stockholders,
scheduled to be held on June 5, 1998, is  incorporated  by reference to Part III
(Items 10, 11, 12 and 13) of this Form 10-K.


<PAGE>
                                  OXiGENE, Inc.
                          (A development stage company)





                    List of Consolidated Financial Statements

The following consolidated financial statements of OXiGENE, Inc. are included in
Item 8:

Report of Independent Auditors...........................................F-2
Consolidated Balance Sheets--December 31, 1997 and 1996..................F-3
Consolidated Statements of Operations--Years Ended December
   31, 1997, 1996 and 1995 and the Period from February 22,
   1988 (Inception) through December 31, 1997 (Unaudited)................F-4
Consolidated Statements of Stockholders' Equity
   (Deficit)--Years  Ended December 31, 1997, 1996, 1995, 1994, 1993,
   1992, 1991 and 1990  (Unaudited),  and the Period from February 22
   (Inception)  through December 31, 1989 (Unaudited)....................F-5
Consolidated Statements of Cash Flows--Years Ended December
   31, 1997, 1996 and 1995 and the Period from February 22,
   1989 (Inception) through December 31, 1997 (Unaudited)................F-15
Notes to Consolidated Financial Statements...............................F-16


Schedules for which provision is made in the applicable accounting regulation of
the  Securities  and  Exchange  Commission  are not  required  under the related
instructions or are inapplicable and, therefore, have been omitted.


<PAGE>


                         Report of Independent Auditors

The Board of Directors and Stockholders
OXiGENE, Inc.


     We have audited the  accompanying  consolidated  balance sheets of OXiGENE,
Inc. (the  "Company") (a development  stage company) as of December 31, 1997 and
1996,  and the related  consolidated  statements  of  operations,  stockholders'
equity (deficit), and cash flows for each of the three years in the period ended
December 31, 1997.  These  financial  statements are the  responsibility  of the
Company's  management.  Our  responsibility  is to  express  an opinion on these
financial statements based on our audits.


     We conducted  our audits in accordance  with  generally  accepted  auditing
standards. Those standards require that we plan and perform the audits to obtain
reasonable assurance about whether the financial statements are free of material
misstatement.  An audit includes examining, on a test basis, evidence supporting
the amounts and disclosures in the financial statements.  An audit also includes
assessing the  accounting  principles  used and  significant  estimates  made by
management,  as well as evaluating the overall financial statement presentation.
We believe that our audits provide a reasonable basis for our opinion.

     In our opinion,  the financial statements referred to above present fairly,
in all material respects,  the consolidated  financial position of OXiGENE, Inc.
(a  development   stage  company)  at  December  31,  1997  and  1996,  and  the
consolidated  results of its operations and its cash flows for each of the three
years in the  period  ended  December  31,  1997 in  conformity  with  generally
accepted accounting principles.




                                                              ERNST & YOUNG LLP

New York, New York
January 12, 1998


<PAGE>


                                  OXiGENE, Inc.
                          (A development stage company)

                           Consolidated Balance Sheets

                                                December 31
                                            1996              1997
                                    ----------------------------------
Assets
Current assets:
   Cash and cash equivalents          $  40,517,182    $  40,136,662
   Prepaid expenses                         194,628          341,912
   Interest receivable                      280,411          300,636
   Other                                     76,626           61,272
                                      -------------    -------------

Total current assets                     41,068,847       40,840,482

Furniture, fixtures and equipment,          143,652          357,876
   at cost
                                      -------------    -------------
Accumulated depreciation                    (53,340)        (125,601)
                                             90,312          232,275
Deposits                                      9,600           79,600

                                      -------------    -------------
Total assets                           $ 41,168,759    $  41,152,357
                                      -------------    -------------


Liabilities and stockholders'
   equity
Current liabilities:
   Accounts payable and accrued
     expenses:
     Accrued expenses                $      225,995    $     778,606
     Other payables                         424,006          172,482
                                      -------------    -------------
Total current liabilities                   650,001          951,088

Commitments (Note 4)

Stockholders' equity (Note 2):
 Common stock, $.01 par value:
     Authorized shares--
       60,000,000 shares at
       December 31, 1996
       60,000,000 shares at
       December 31, 1997
     Issued and outstanding shares--
       9,052,343 shares at
       December 31, 1996;                    90,523          101,858
       10,185,765 shares at
       December 31, 1997
   Additional paid-in capital            57,673,667       65,348,603
   Deficit accumulated during the       (17,358,307)     (25,468,828)
     development stage
   Foreign currency translation             112,875          219,636
     adjustment
                                      -------------    -------------
Total stockholders' equity               40,518,758       40,201,269
                                      -------------    -------------
Total liabilities and                 $  41,168,759    $  41,152,357
   stockholders' equity
                                      =============   ==============

See accompanying notes.


<PAGE>

<TABLE>
<CAPTION>

                                  OXiGENE, Inc.
                          (A development stage company)

                      Consolidated Statements of Operations


                                                                             Period from
                                                                          February 22, 1988
                                                                             (inception)
                                        Year ended December 31                 through
                                  1995           1996           1997      December 31, 1997
                                  ----           ----           ----      -----------------
                                                                             (Unaudited)

<S>                           <C>            <C>               <C>              <C>
Revenues
Research income               $          -   $          -     $         -       $    31,000
Interest income                    420,949        684,039       2,217,467          3,648,747
                                   -------        -------       ---------          ---------
                                   420,949        684,039       2,217,467          3,679,747

Operating expenses
 Research and development:
   CATO Research, Ltd.             739,994        318,210         166,640          2,950,073
     (Note 5)
   Other                         2,103,599      4,504,624       7,114,864         16,224,025
                                 ---------      ---------       ---------         ----------
Total research and               2,843,593      4,822,834       7,281,504         19,174,098
   development
General and administrative
   (including related party
   transactions of
   approximately $72,000,
   $336,000 and $494,000 in      1,295,191      1,819,638       3,046,484          9,974,477
   1995, 1996 and 1997)
   (Note 5)

Total operating expenses         4,138,784      6,642,472      10,327,988         29,148,575
                                 ---------      ---------      ----------         ----------
Net loss                       $(3,717,835)  $ (5,958,433)   $ (8,110,521)     $(25,468,828)
                               ===========   ============    ============      ============

Net loss per common share         $(.63)         $(.80)         $(.83)
Weighted average number of
   common shares outstanding     5,876,295      7,439,616       9,770,364

See accompanying notes.
</TABLE>



<PAGE>
                                  OXiGENE, Inc.
                          (a development stage company)
                  Statements of Stockholders' Equity (Deficit)
                                    (Note 2)
<TABLE>
<CAPTION>
                                                                                           Common Stock,
                                                                                          $.01 Par Value
                                                                                 ---------------------------
                                                                 Date                  Shares        Amounts
                                                            ------------------------------------------------------
<S>                                                      <C>                      <C>             <C>    
Issuance of common stock in exchange for
   transfer of patent application ownership
   to the Company by an officer/director                        May 1988           380,000         $  3,800
   recorded at no value, which reflects
   transferor's basis (unaudited)

Issuance of common stock at approximately                      June 1988           271,033            2,710
   $0.74 per share (unaudited)

Issuance of common stock in exchange for the
   outstanding common stock of Bio-Screen                    August 1988           100,000            1,000
   Inc. (unaudited)

Net loss for period from February 22, 1988
   (inception) through                                                                   -                -
   December 31, 1988 (unaudited)

                                                                             ----------------------------------------
Balance at December 31, 1988 (unaudited)                                           751,033            7,510

Issuance of common stock at approximately                   January 1989           271,033            2,710
   $0.74 per share (unaudited)

Net loss for 1989 (unaudited)                                                            -                -

                                                                             ----------------------------------------
Balance at December 31, 1989 (unaudited)                                         1,022,066           10,220

Issuance of common stock at approximately                  March 1990 to
   $0.74 per share                                         December 1990           257,487            2,575

Common stock subscribed                                    December 1990                 -                -

Net loss for 1990                                                                        -                -

                                                                             ----------------------------------------
Balance at December 31, 1990                                                     1,279,553           12,795

Issuance of common stock at approximately                   January 1991            13,547              136
   $0.74 per share

Issuance of common stock                                   February 1991           330,000            3,300
   at $0.71 per share

Issuance of common stock at approximately                    August 1991           100,000            1,000
   $1.50 per share

Issuance of common stock at                                December 1991           220,000            2,200
   $1.95 per share

Net loss for 1991                                                                        -                -
                                                                             ----------------------------------------
Balance at December 31, 1991                                                     1,943,100           19,431

Issuance of common stock at
   1.95 per share, net of issuance                         December 1992           985,000            9,850
   costs of approximately $121,000

Net loss for 1992                                                                        -                -
                                                                             ----------------------------------------
Balance at December 31, 1992                                                     2,928,100           29,281

</TABLE>
<PAGE>
<TABLE>
<CAPTION>
                                                                    Common Stock Subscribed             Additional
                                                              --------------------------------           Paid-In
                                                                Shares                   Amount          Capital
                                                              -------------------------------------------------------
<S>                                                      <C>                         <C>                <C> 
Issuance of common stock in exchange for
   transfer of patent application ownership
   to the Company by an officer/director                         -                    $      -           $ (3,800)
   recorded at no value, which reflects                   
   transferor's basis (unaudited)                         
                                                          
Issuance of common stock at approximately                        -                           -            197,290
   $0.74 per share (unaudited)                            
                                                          
Issuance of common stock in exchange for the              
   outstanding common stock of Bio-Screen                        -                           -             (1,000)
   Inc. (unaudited)                                       
                                                          
Net loss for period from February 22, 1988                
   (inception) through                                           -                           -                  -
   December 31, 1988 (unaudited)                          
                                                          
                                                          ------------------------------------------------------------
Balance at December 31, 1988 (unaudited)                         -                           -            192,490
                                                          
Issuance of common stock at approximately                        -                           -            197,290
   $0.74 per share (unaudited)                            
                                                          
Net loss for 1989 (unaudited)                                    -                           -                  -
                                                          ------------------------------------------------------------
                                                      
Balance at December 31, 1989 (unaudited)                         -                           -            389,780
                                                          
Issuance of common stock at approximately                 
   $0.74 per share                                               -                           -            187,425
                                                          
Common stock subscribed                                     13,547                      10,000                  -
                                                          
Net loss for 1990                                                -                           -                  -
                                                          
                                                          ------------------------------------------------------------
Balance at December 31, 1990                                13,547                      10,000            577,205
                                                          
Issuance of common stock at approximately                  (13,547)                    (10,000)             9,864
   $0.74 per share                                        
                                                          
Issuance of common stock at                                      -                           -            230,033
   $0.71 per share                                        
                                                          
Issuance of common stock at approximately                        -                           -            149,000
   $1.50 per share                                        
                                                          
Issuance of common stock at                                      -                           -            426,800
   $1.95 per share                                        
                                                          
Net loss for 1991                                                -                           -                  -
                                                          
Balance at December 31, 1991                                     -                           -          1,392,902
                                                          
                                                          ------------------------------------------------------------
Issuance of common stock at                               
   $1.95 per share, net of issuance costs of                     -                           -          1,789,866
   approximately $121,000                                 
                                                          
Net loss for 1992                                                -                           -                  -
                                                          
                                                          ------------------------------------------------------------
Balance at December 31, 1992                                     -                           -          3,182,768

</TABLE>
<PAGE>

                                  OXiGENE, Inc.
                          (a development stage company)

            Statements of Stockholders' Equity (Deficit) (continued)
                                    (Note 2)

<TABLE>
<CAPTION>
                                                   Deficit Accumulated During the                Foreign Currency 
                                                         Development Stage                    Translation Adjustment
                                                 --------------------------------------------------------------------
<S>                                                             <C>                                  <C>  
Issuance of common stock in exchange for
   transfer of patent application ownership
   to the Company by an officer/director                        $         -                      $     -
   recorded at no value, which reflects
   transferor's basis (unaudited)

Issuance of common stock at approximately                                 -                            -
   $0.74 per share (unaudited)

Issuance of common stock in exchange for the
   outstanding common stock of Bio-Screen                                 -                            -
   Inc. (unaudited)

Net loss for period from February 22, 1988
   (inception) through December 31, 1988                          (185,962)                            -
   (unaudited)
                                                 --------------------------------------------------------------------
Balance at December 31, 1988 (unaudited)                          (185,962)                            -

Issuance of common stock at approximately                                 -                            -
   $0.74 per share (unaudited)

Net loss for 1989 (unaudited)                                     (179,119)                            -
                                                 --------------------------------------------------------------------
Balance at December 31, 1989 (unaudited)                          (365,081)                            -

Issuance of common stock at approximately                                 -                            -
   $0.74 per share


Common stock subscribed                                                   -                            -

Net loss for 1990                                                 (326,648)                            -
                                                 --------------------------------------------------------------------
Balance at December 31, 1990                                      (691,729)                            -

Issuance of common stock at approximately                                 -                            -
   $0.74 per share

Issuance of common stock at                                               -                            -
   $0.71 per share

Issuance of common stock at approximately                                 -                            -
   $1.50 per share

Issuance of common stock at                                               -                            -
   $1.95 per share

Net loss for 1991                                                 (501,872)                            -
                                                 --------------------------------------------------------------------
Balance at December 31, 1991                                    (1,193,601)                            -

Issuance of common stock at
   $1.95 per share, net of issuance costs of                              -                            -
   approximately $121,000

Net loss for 1992                                               (1,628,667)                            -
                                                 --------------------------------------------------------------------
Balance at December 31, 1992                                    (2,822,268)                            -

</TABLE>
<PAGE>

<TABLE>
<CAPTION>



                                                                           Unrealized
                                                         Stock             Losses on                 Total
                                                      Subscription         Securities             Stockholders'
                                                        and Notes         Available for             Equity
                                                       Receivable             Sale                 (Deficit)
                                                    -----------------------------------------------------------
<S>                                                <C>                  <C>                     <C>

Issuance of common stock in exchange for
   transfer of patent application ownership
   to the Company by an officer/director            $      -             $       -              $         -
   recorded at no value, which reflects
   transferor's basis (unaudited)

Issuance of common stock at approximately                  -                     -                  200,000
   $0.74 per share (unaudited)

Issuance of common stock in exchange for
   the outstanding common stock of                         -                     -                        -
   Bio-Screen Inc. (unaudited)

Net loss for period from February 22, 1988
   (inception) through December 31, 1988                   -                     -                 (185,962)
   (unaudited)

Balance at December 31, 1988 (unaudited)                   -                     -                   14,038

Issuance of common stock at approximately                  -                     -                  200,000
   $0.74 per share (unaudited)

Net loss for 1989 (unaudited)                              -                     -                 (179,119)
Balance at December 31, 1989 (unaudited)                   -                     -                   34,919

Issuance of common stock at approximately                  -                     -                  190,000
   $0.74 per share


Common stock subscribed                              (10,000)                    -                        -

Net loss for 1990                                          -                     -                 (326,648)

Balance at December 31, 1990                         (10,000)                    -                 (101,729)

Issuance of common stock at approximately             10,000                     -                   10,000
   $0.74 per share

Issuance of common stock at $0.71 per share                -                     -                  233,333

Issuance of common stock at approximately                  -                     -                  150,000
   $1.50 per share

Issuance of common stock at $1.95 per share                -                     -                  429,000

Net loss for 1991                                          -                     -                 (501,872)

Balance at December 31, 1991                               -                     -                  218,732

Issuance of common stock at $1.95 per
   share, net of issuance costs of                  (360,750)                    -                1,438,966
   approximately $121,000

Net loss for 1992                                          -                     -               (1,628,667)
                                                   ---------------------------------------------------------
Balance at December 31, 1992                        (360,750)                    -                   29,031

</TABLE>
<PAGE>



                                  OXiGENE, Inc.
                          (a development stage company)

            Statements of Stockholders' Equity (Deficit) (continued)
                                    (Note 2)

<TABLE>
<CAPTION>
                                                                                       Common Stock,
                                                                                      $.01 Par Value
                                                                            -----------------------------------------
                                                       Date                  Shares                 Amounts
                                                   ------------------------------------------------------------------
<S>                                                <C>                    <C>                      <C> 

 Issuance of common stock at $1.95 per             January 1993 to
   share, net of issuance costs of                 February 1993             445,000                $     4,450
   approximately $136,500

 Repayment of notes receivable                     January 1993                    -                          -

 Issuance of warrants and options as
   compensation to certain directors to
   purchase 180,000 and 10,000 shares              May 1993                        -                          -
   of common stock, respectively, at
   $1.95 per share

 Issuance of common stock at $6.00 per
   share, net of issuance costs of                 September 1993          1,500,000                     15,000
   approximately $1,836,000

 Issuance of common stock at $6.00 per
   share, net of issuance costs of                 October 1993              105,000                      1,050
   approximately $82,000

 Net loss for 1993                                                                 -                          -
                                                                       ----------------------------------------------
 Balance at December 31, 1993                                              4,978,100                     49,781

 Issuance of common stock at $1.95 per             April 1994                 80,000                        800
   share

 Net loss for 1994                                                                 -                          -
                                                                       ----------------------------------------------
 Unrealized losses on securities                                                   -                          -
   available-for-sale
                                                                       ----------------------------------------------
 Balance at December 31, 1994                                              5,058,100                     50,581

 Issuance of options as compensation to
   consultants to purchase 165,000                 June 1995                       -                          -
   shares of common stock at $6.00 per
   share

 Issuance of common stock at $6.00 per
   share, net of issuance costs of                 July 1995               1,666,700                     16,667
   approximately $524,000

 Issuance of common stock at $1.50 per             July 1995 to
   share (12,500) and $1.95 per share              December 1995              98,500                        985
   (86,000)

 Subscriptions for 5,000 shares of                 December 1995                   -                          -
   common stock at $1.95 per share

 Foreign currency translation                                                      -                          -
   adjustment for 1995

 Net loss for 1995                                                                 -                          -

 Unrealized gain on securities                                                     -                          -
   available-for-sale
                                                                       ----------------------------------------------
 Balance at December 31, 1995                                              6,823,300                     68,233

</TABLE>
<PAGE>
<TABLE>
<CAPTION>
                                                         Common Stock Subscribed                  Additional
                                             -------------------------------------------           Paid-In
                                                       Shares                Amount                Capital
                                             ------------------------------------------------------------------------
<S>                                             <C>                        <C>                 <C>

 Issuance of common stock at $1.95 per
   share, net of issuance costs of                   -                      $  -                $    726,800
   approximately $136,500

 Repayment of notes receivable                       -                         -                           -

 Issuance of warrants and options as
   compensation to certain directors
   to purchase 180,000 and 10,000                    -                         -                     427,500
   shares of common stock,
   respectively, at $1.95 per share

 Issuance of common stock at $6.00 per
   share, net of issuance costs of                   -                         -                   7,149,247
   approximately $1,836,000

 Issuance of common stock at $6.00 per
   share, net of issuance costs of                   -                         -                     547,050
   approximately $82,000

 Net loss for 1993                                   -                         -                           -
                                             ------------------------------------------------------------------------
 Balance at December 31, 1993                        -                         -                  12,033,365

 Issuance of common stock at $1.95 per               -                         -                     155,200
   share

 Net loss for 1994                                   -                         -                           -

 Unrealized losses on securities                     -                         -                           -
   available-for-sale
                                             ------------------------------------------------------------------------
 Balance at December 31, 1994                        -                         -                  12,188,565

 Issuance of options as compensation
   to consultants to purchase 165,000                -                         -                      20,625
   shares of common stock at $6.00 per
   share

 Issuance of common stock at $6.00 per
   share, net of issuance costs of                   -                         -                   9,460,009
   approximately $524,000

 Issuance of common stock at $1.50 per
   share (12,500) and $1.95 per share                -                         -                     185,465
   (86,000)

 Subscriptions for 5,000 shares of               5,000                        50                       9,700
   common stock at $1.95 per share

 Foreign currency translation                        -                         -                           -
   adjustment for 1995

 Net loss for 1995                                   -                         -                           -

 Unrealized gain on securities                       -                         -                           -
   available-for-sale
                                             ------------------------------------------------------------------------
 Balance at December 31, 1995                    5,000                        50                  21,864,364

</TABLE>
<PAGE>
                                  OXiGENE, Inc.
                          (a development stage company)

            Statements of Stockholders' Equity (Deficit) (continued)
                                    (Note 2)
<TABLE>
<CAPTION>
                                                 Deficit 
                                               Accumulated                Foreign                   Stock and
                                                 During the               Currency                Subscription 
                                                Development             Translation                 and Notes
                                                   Stage                 Adjustment                 Receivable
                                         ----------------------------------------------------------------------------
<S>                                       <C>                      <C>                        <C>
 Issuance of common stock at $1.95
   per share, net of issuance costs        $          -             $        -                $       -
   of approximately $136,500

 Repayment of notes receivable                        -                      -                  360,750

 Issuance of warrants and options
   as compensation to certain
   directors to purchase 180,000                      -                      -                        -
   and 10,000 shares of common
   stock, respectively, at $1.95
   per share

 Issuance of common stock at $6.00
   per share, net of issuance costs                   -                      -                        -
   of  approximately $1,836,000

 Issuance of common stock at $6.00
   per share, net of issuance costs                   -                      -                        -
   of approximately $82,000

 Net loss for 1993                           (2,020,012)                     -                        -
                                         ----------------------------------------------------------------------------
 Balance at December 31, 1993                (4,842,280)                     -                        -

 Issuance of common stock at $1.95                    -                      -                        -
   per share

 Net loss for 1994                           (2,839,759)                     -                        -

 Unrealized losses on securities                      -                      -                        -
   available-for-sale

                                         ----------------------------------------------------------------------------
 Balance at December 31, 1994                (7,682,039)                     -                        -

 Issuance of options as
   compensation to consultants to                     -                      -                        -
   purchase 165,000 shares of
   common stock at $6.00 per share

 Issuance of common stock at $6.00
   per share, net of issuance costs                   -                      -                        -
   of approximately $524,000

 Issuance of common stock at $1.50
   per share (12,500) and $1.95 per                   -                      -                        -
   share (86,000)

 Subscriptions for 5,000 shares of                    -                      -                        -
   common stock at $1.95 per share

 Foreign currency translation                         -                 24,894                        -
   adjustment for 1995

 Net loss for 1995                           (3,717,835)                     -                        -

 Unrealized gain on securities                        -                      -                        -
   available-for-sale
                                         ----------------------------------------------------------------------------
 Balance at December 31, 1995               (11,399,874)                24,894                        -
</TABLE>
<PAGE>

<TABLE>
<CAPTION>

                                                  Unrealized Losses on Securities       Total Stockholders' Equity
                                                           Available for
                                                                Sale                             (Deficit)
                                                 -----------------------------------------------------------------
<S>                                              <C>                                     <C>  
 Issuance of common stock at $1.95 per
   share, net of issuance costs of                $      -                               $    731,250
   approximately $136,500

 Repayment of notes receivable                           -                                    360,750

 Issuance of warrants and options as
   compensation to certain directors to
   purchase 180,000 and 10,000 shares of                 -                                    427,500
   common stock, respectively, at $1.95
   per share

 Issuance of common stock at $6.00 per
   share, net of issuance costs of                       -                                  7,164,247
   approximately $1,836,000

 Issuance of common stock at $6.00 per
   share, net of issuance costs of                       -                                    548,100
   approximately $82,000

 Net loss for 1993                                       -                                 (2,020,012)
                                                   ---------------------------------------------------------------

 Balance at December 31, 1993                            -                                  7,240,866

 Issuance of common stock at $1.95 per                   -                                    156,000
   share

 Net loss for 1994                                       -                                 (2,839,759)

 Unrealized losses on securities                   (77,125)                                   (77,125)
   available-for-sale

                                                   ----------------------------------------------------------------
 Balance at December 31, 1994                      (77,125)                                 4,479,982

 Issuance of options as compensation to
   consultants to purchase 165,000                       -                                     20,625
   shares of common stock at $6.00 per
   share

 Issuance of common stock at $6.00 per
   share, net of issuance costs of                       -                                  9,476,676
   approximately $524,000

 Issuance of common stock at $1.50 per
   share (12,500) and $1.95 per share                    -                                    186,450
   (86,000)

 Subscriptions for 5,000 shares of                       -                                      9,750
   common stock at $1.95 per share

 Foreign currency translation adjustment                 -                                     24,894
   for 1995

 Net loss for 1995                                       -                                 (3,717,835)

 Unrealized gain on securities                      76,632                                     76,632
   available-for-sale
                                                    -----------------------------------------------------------------
 Balance at December 31, 1995                         (493)                                10,557,174

</TABLE>
<PAGE>
                                  OXiGENE, Inc.
                          (a development stage company)
            Statements of Stockholders' Equity (Deficit) (continued)
                                    (Note 2)
<TABLE>
<CAPTION>
                                                                                          Common Stock,
                                                                                          $.01 Par Value
                                                                              ---------------------------------------
                                                                Date                Shares             Amounts
                                                       --------------------------------------------------------------
<S>                                                   <C>                         <C>            <C>
Issuance of common stock upon  
   exercise of options, warrants
   or stock appreciation rights (SAR):

     At $1.95 per share                                January 1996                   5,000       $     50

     At $1.95 per share                                January 1996                  50,000            500

     At $1.95 per share                                March 1996                    95,000            950

     At $1.95 per share                                April 1996                    50,000            500

     At $7.25 per share                                June 1996                      2,500             25

     At $9.67 per share                                June 1996                    120,482          1,206

     At $1.95 per share                                June 1996                     75,000            750

     At $1.95 per share                                July 1996                     50,000            500

     At $5.50 per share                                July 1996                      5,000             50

     At $10.35 per share                               July 1996                     49,755            498

     At $7.25 per share                                July 1996                     10,000            100

     At $1.95 per share                                August 1996                   31,500            315

     At $7.25 per share                                August 1996                    2,500             25

     At $22.00 per share (SAR)                         August 1996                    5,129             51

     At $9.67 per share                                August 1996                  270,342          2,702

     At $21.00 per share (SAR)                         September 1996                 1,910             19

     At $11.54 per share                               October 1996                   8,560             86

     At $1.95 per share                                November 1996                  5,000             50

     At $6.25 per share                                November 1996                 50,000            500

     At $8.95 per share                                November 1996                 27,250            272

     At $7.25 per share                                November 1996                 42,150            422

     At $11.54 per share                               November 1996                 52,965            529

     At $15.74 per share                               November 1996                 69,000            690

Capital contribution by officer                        June 1996                          -              -

Public offering of common stock
   at $25.2732 per share, net of issuance
   costs of approximately $2,217,000                   November 1996              1,150,000         11,500

Foreign currency translation                                                              -              -
   adjustment for 1996

Net loss for 1996                                                                         -              -

Accrued stock appreciation rights                                                         -              -

Unrealized gain on securities                                                             -              -
   available-for-sale
                                                                              ---------------------------------------
Balance at December 31, 1996                                                      9,052,343         90,523
</TABLE>
<PAGE>
<TABLE>
<CAPTION>


                                                                 Common Stock Subscribed             Additional
                                                       -----------------------------------------       Paid-In
                                                               Shares               Amount             Capital
                                                       -----------------------------------------------------------
<S>                                                      <C>                    <C>              <C>

Issuance of common stock upon
  exercise of options, warrants
  or stock appreciation rights (SAR):

     At $1.95 per share                                   (5,000)                $(50)                     $ -

     At $1.95 per share                                        -                    -                   97,000

     At $1.95 per share                                        -                    -                  184,300

     At $1.95 per share                                        -                    -                   97,000

     At $7.25 per share                                        -                    -                   18,100

     At $9.67 per share                                        -                    -                1,164,204

     At $1.95 per share                                        -                    -                  145,500

     At $1.95 per share                                        -                    -                   97,000

     At $5.50 per share                                        -                    -                   27,450

     At $10.35 per share                                       -                    -                  480,777

     At $7.25 per share                                        -                    -                   72,400

     At $1.95 per share                                        -                    -                   61,110

     At $7.25 per share                                        -                    -                   18,100

     At $22.00 per share (SAR)                                 -                    -                  112,789

     At $9.67 per share                                        -                    -                2,612,318

     At $21.00 per share (SAR)                                 -                    -                   40,091

     At $11.54 per share                                       -                    -                   98,714

     At $1.95 per share                                        -                    -                    9,700

     At $6.25 per share                                        -                    -                  312,000

     At $8.95 per share                                        -                    -                  243,615

     At $7.25 per share                                        -                    -                  370,021

     At $11.54 per share                                       -                    -                  610,796

     At $15.74 per share                                       -                    -                  943,710

Capital contribution by officer                                -                    -                   53,170

Public offering of common stock
   at $25.2732 per share, net of issuance
   costs of approximately $2,217,000                           -                    -               26,835,896

Foreign currency translation                                   -                    -                        -
   adjustment for 1996

Net loss for 1996                                              -                    -                        -

Accrued stock appreciation rights                              -                    -                1,103,542

Unrealized gain on securities                                  -                    -                        -
   available-for-sale
                                                       -----------------------------------------------------------
Balance at December 31, 1996                                   -                    -               57,673,667
</TABLE>
<PAGE>
                                  OXiGENE, Inc.
                          (a development stage company)
            Statements of Stockholders' Equity (Deficit) (continued)
                                    (Note 2)
<TABLE>
<CAPTION>

                                                       Deficit
                                                     Accumulated           Foreign                 Stock 
                                                      During the           Currency           Subscription and
                                                      Development         Translation              Notes
                                                        Stage              Adjustment            Receivable
                                              -----------------------------------------------------------------------
<S>                                            <C>                         <C>             <C>
Issuance of common stock upon
  exercise of options, warrants
  or stock appreciation rights (SAR):

     At $1.95 per share                         $          -               $        -       $     -
     At $1.95 per share                                    -                        -             -
     At $1.95 per share                                    -                        -             -
     At $1.95 per share                                    -                        -             -
     At $7.25 per share                                    -                        -             -
     At $9.67 per share                                    -                        -             -
     At $1.95 per share                                    -                        -             -
     At $1.95 per share                                    -                        -             -
     At $5.50 per share                                    -                        -             -
     At $10.35 per share                                   -                        -             -
     At $7.25 per share                                    -                        -             -
     At $1.95 per share                                    -                        -             -
     At $7.25 per share                                    -                        -             -
     At $22.00 per share (SAR)                             -                        -             -
     At $9.67 per share                                    -                        -             -
     At $21.00 per share (SAR)                             -                        -             -
     At $11.54 per share                                   -                        -             -
     At $1.95 per share                                    -                        -             -
     At $6.25 per share                                    -                        -             -
     At $8.95 per share                                    -                        -             -
     At $7.25 per share                                    -                        -             -
     At $11.54 per share                                   -                        -             -
     At $15.74 per share                                   -                        -             -

Capital contribution by officer                            -                        -             -

Public offering of common
   stock at $25.2732 per share,
   net of issuance costs of approximately                  -                        -             -
   $2,217,000

Foreign currency translation adjustment for                -                   87,981             -
   1996

Net loss for 1996                                 (5,958,433)                       -             -

Accrued stock appreciation rights                          -                        -             -

Unrealized gain on securities                              -                        -             -
   available-for-sale
                                              -----------------------------------------------------------------------
Balance at December 31, 1996                     (17,358,307)                 112,875             -
</TABLE>
<PAGE>

<TABLE>
<CAPTION>
                                              Unrealized Losses on Securities    Total Stockholders' 
                                                    Available for Sale            Equity (Deficit)
                                              ---------------------------------------------------------
<S>                                              <C>                             <C>    
Issuance of common stock upon
   exercise of options, warrants or
   stock appreciation rights (SAR):

     At $1.95 per share                           $    -                         $          -
     At $1.95 per share                                -                               97,500
     At $1.95 per share                                -                              185,250
     At $1.95 per share                                -                               97,500
     At $7.25 per share                                -                               18,125
     At $9.67 per share                                -                            1,165,410
     At $1.95 per share                                -                              146,250
     At $1.95 per share                                -                               97,500
     At $5.50 per share                                -                               27,500
     At $10.35 per share                               -                              481,275
     At $7.25 per share                                -                               72,500
     At $1.95 per share                                -                               61,425
     At $7.25 per share                                -                               18,125
     At $22.00 per share (SAR)                         -                              112,840
     At $9.67 per share                                -                            2,615,020
     At $21.00 per share (SAR)                         -                               40,110
     At $11.54 per share                               -                               98,800
     At $1.95 per share                                -                                9,750
     At $6.25 per share                                -                              312,500
     At $8.95 per share                                -                              243,887
     At $7.25 per share                                -                              370,443
     At $11.54 per share                               -                              611,325
     At $15.74 per share                               -                              944,400

Capital contribution by officer                        -                               53,170

Public offering of common
   stock at $25.2732 per share,
   net of issuance costs of approximately              -                           26,847,396
   $2,217,000

Foreign currency translation adjustment for            -                               87,981
   1996

Net loss for 1996                                      -                           (5,958,433)

Accrued stock appreciation rights                      -                            1,103,542

Unrealized gain on securities                        493                                  493
   available-for-sale
                                                   ------------------------------------------------------------------
Balance at December 31, 1996                           -                           40,518,758
</TABLE>
<PAGE>
                                  OXiGENE, Inc.
                          (a development stage company)

            Statements of Stockholders' Equity (Deficit) (continued)
                                    (Note 2)
<TABLE>
<CAPTION>
                                                                                          Common Stock,
                                                                                          $.01 Par Value
                                                                               --------------------------------------
                                                                Date                Shares             Amounts
                                                       --------------------------------------------------------------
<S>                                                     <C>                          <C>            <C> 
Issuance of common stock upon
   exercise of options, warrants or
   stock appreciation rights (SAR):

     At prices ranging from $25.50                     January 1997                   3,690       $     37
     to $32.25 (SAR)

     At $8.95 per share                                January 1997                  32,700            328

     At $11.54 per share                               January 1997                  34,240            343

     At $5.50 per share                                February 1997                 25,000            250

     At $7.25 per share                                February 1997                 45,000            450

     At $11.54 per share                               February 1997                 32,324            322

     At $34.50 per share (SAR)                         February 1997                    473              5

     At $5.50 per share                                March 1997                    15,000            150

     At $7.25 per share                                March 1997                     2,500             25

     At $11.54 per share                               March 1997                    52,930            529

     At $13.69 per share                               March 1997                    34,500            344

     At $33.50 per share (SAR)                         March 1997                       391              4

     At $1.95 per share                                April 1997                   285,000          2,850

     At $5.50 per share                                April 1997                    80,000            800

     At $7.25 per share                                April 1997                   100,000          1,000

     At $11.54 per share                               April 1997                    17,253            173

     At $5.50 per share                                May 1997                       5,000             50

     At $6.94 per share                                May 1997                       2,000             20

     At $7.00 per share                                May 1997                       5,000             50

     At $7.25 per share                                May 1997                       5,000             50

     At $11.54 per share                               May 1997                      13,979            140

     At $1.95 per share                                June 1997                     10,000            100

     At $5.50 per share                                June 1997                      5,000             50

     At $7.00 per share                                June 1997                      5,000             50
</TABLE>
<PAGE>

<TABLE>
<CAPTION>

                                                                                                     
                                                                Common Stock Subscribed               Additional
                                                       -----------------------------------------        Paid-In
                                                               Shares               Amount              Capital
                                                       ------------------------------------------------------------
<S>                                                        <C>                   <C>                   <C>

Issuance of common stock upon exercise
  of options, warrants or stock
  appreciation rights (SAR):

     At prices ranging from $25.50                             -                 $  -                 $ 98,023
     to $32.25 (SAR)

     At $8.95 per share                                        -                    -                  292,338

     At $11.54 per share                                       -                    -                  394,857

     At $5.50 per share                                        -                    -                  137,250

     At $7.25 per share                                        -                    -                  325,800

     At $11.54 per share                                       -                    -                  372,772

     At $34.50 per share (SAR)                                 -                    -                   16,345

     At $5.50 per share                                        -                    -                   82,350

     At $7.25 per share                                        -                    -                   18,100

     At $11.54 per share                                       -                    -                  610,401

     At $13.69 per share                                       -                    -                  471,856

     At $33.50 per share (SAR)                                 -                    -                   13,121

     At $1.95 per share                                        -                    -                  552,900

     At $5.50 per share                                        -                    -                  439,200

     At $7.25 per share                                        -                    -                  724,000

     At $11.54 per share                                       -                    -                  198,972

     At $5.50 per share                                        -                    -                   27,450

     At $6.94 per share                                        -                    -                   13,860

     At $7.00 per share                                        -                    -                   34,950

     At $7.25 per share                                        -                    -                   36,200

     At $11.54 per share                                       -                    -                  161,213

     At $1.95 per share                                        -                    -                   19,400

     At $5.50 per share                                        -                    -                   27,450

     At $7.00 per share                                        -                    -                   34,950
</TABLE>
<PAGE>


                                  OXiGENE, Inc.
                          (a development stage company)

            Statements of Stockholders' Equity (Deficit) (continued)
                                    (Note 2)
<TABLE>
<CAPTION>
                                                        Deficit Accumulated
                                                            During the           Foreign Currency   Stock Subscription
                                                            Development            Translation           and Notes
                                                               Stage                Adjustment          Receivable
                                                       --------------------------------------------------------------
<S>                                                    <C>                   <C>                  <C>  
 Issuance of common stock upon exercise
   of options, warrants or stock
   appreciation rights (SAR):

     At prices ranging from $25.50 to                   $          -          $        -           $     -
     $32.25 (SAR)

     At $8.95 per share                                             -                   -                 -

     At $11.54 per share                                            -                   -                 -

     At $5.50 per share                                             -                   -                 -

     At $7.25 per share                                             -                   -                 -

     At $11.54 per share                                            -                   -                 -

     At $34.50 per share (SAR)                                      -                   -                 -

     At $5.50 per share                                             -                   -                 -

     At $7.25 per share                                             -                   -                 -

     At $11.54 per share                                            -                   -                 -

     At $13.69 per share                                            -                   -                 -

     At $33.50 per share (SAR)                                      -                   -                 -

     At $1.95 per share                                             -                   -                 -

     At $5.50 per share                                             -                   -                 -

     At $7.25 per share                                             -                   -                 -

     At $11.54 per share                                            -                   -                 -

     At $5.50 per share                                             -                   -                 -

     At $6.94 per share                                             -                   -                 -

     At $7.00 per share                                             -                   -                 -

     At $7.25 per share                                             -                   -                 -

     At $11.54 per share                                            -                   -                 -

     At $1.95 per share                                             -                   -                 -

     At $5.50 per share                                             -                   -                 -

     At $7.00 per share                                             -                   -                 -
</TABLE>
<PAGE>
<TABLE>
<CAPTION>

                                                        Unrealized Losses on
                                                        Securities Available      Total Stockholders' Equity
                                                              for Sale                    (Deficit)
                                                        ----------------------------------------------------------
<S>                                                      <C>                              <C>
Issuance of common stock upon exercise of
  options, warrants or stock appreciation
  rights (SAR):

     At prices ranging from $25.50 to                       $   -                            $
     $32.25 (SAR)                                                                                98,060

     At $8.95 per share                                         -                               292,666

     At $11.54 per share                                        -                               395,200

     At $5.50 per share                                         -                               137,500

     At $7.25 per share                                         -                               326,250

     At $11.54 per share                                        -                               373,094

     At $34.50 per share (SAR)                                  -                                16,350

     At $5.50 per share                                         -                                82,500

     At $7.25 per share                                         -                                18,125

     At $11.54 per share                                        -                               610,930

     At $13.69 per share                                        -                               472,200

     At $33.50 per share (SAR)                                  -                                13,125

     At $1.95 per share                                         -                               555,750

     At $5.50 per share                                         -                               440,000

     At $7.25 per share                                         -                               725,000

     At $11.54 per share                                        -                               199,145

     At $5.50 per share                                         -                                27,500

     At $6.94 per share                                         -                                13,880

     At $7.00 per share                                         -                                35,000

     At $7.25 per share                                         -                                36,250

     At $11.54 per share                                        -                               161,353

     At $1.95 per share                                         -                                19,500

     At $5.50 per share                                         -                                27,500

     At $7.00 per share                                         -                                35,000
</TABLE>
<PAGE>
                                  OXiGENE, Inc.
                          (a development stage company)

            Statements of Stockholders' Equity (Deficit) (continued)
                                    (Note 2)
<TABLE>
<CAPTION>

                                                                                    Common Stock,
                                                                                    $.01 Par Value
                                                                    -------------------------------------------------
                                                Date                     Shares                   Amounts
                                          ---------------------------------------------------------------------------
<S>                                       <C>                          <C>                        <C>
     At $7.25 per share                   June 1997                      15,000                   $      150

     At $11.54 per share                  June 1997                      32,782                          327

     At $8.95 per share                   July 1997                      16,350                          163

     At $11.54 per share                  July 1997                       2,033                           20

     At $15.74 per share                  July 1997                      17,250                          172

     At $11.54 per share                  August 1997                   120,801                        1,209

     At $5.38 per share                   September 1997                 10,000                          100

     At $7.25 per share                   September 1997                  1,000                           10

     At $13.41 per share                  September 1997                  1,070                           11

     At $5.38 per share                   October 1997                    5,000                           50

     At $7.25 per share                   October 1997                    5,000                           50

     At prices ranging from $25.75        October 1997                    7,437                           75
     to $27.00 (SAR)

     At $5.50 per share                   November 1997                  30,000                          300

     At $ 6.00 per share                  November 1997                   5,000                           50

     At $6.375 per share                  November 1997                  46,666                          467

     At $19.75 per share   (SAR)          November 1997                   1,053                           11

     At $5.38 per share                   December 1997                   5,000                           50

Foreign currency translation                                                  -                            -
   adjustment for 1997

Net loss for 1997                                                             -                            -

Accrued stock appreciation rights                                             -                            -
                                                                  ---------------------------------------------------
Balance at December 31, 1997                                         10,185,765         $            101,858
                                                                  ===================================================
</TABLE>
<PAGE>
<TABLE>
<CAPTION>


                                                Common Stock Subscribed                          Additional
                                    --------------------------------------------------            Paid-In
                                                 Shares                    Amount                 Capital
                                    -----------------------------------------------------------------------
<S>                                        <C>                         <C>                 <C> 
     At $7.25 per share                     -                           $   -               $      108,600

     At $11.54 per share                    -                               -                      378,052

     At $8.95 per share                     -                               -                      146,169

     At $11.54 per share                    -                               -                       23,445

     At $15.74 per share                    -                               -                      235,928

     At $11.54 per share                    -                               -                    1,393,106

     At $5.38 per share                     -                               -                       53,700

     At $7.25 per share                     -                               -                        7,240

     At $13.41 per share                    -                               -                       14,339

     At $5.38 per share                     -                               -                       26,850

     At $7.25 per share                     -                               -                       36,200

     At prices ranging from $25.75          -                               -                      200,141
     to $27.00 (SAR)

     At $5.50 per share                     -                               -                      164,700

     At $ 6.00 per share                    -                               -                       29,950

     At $6.375 per share                    -                               -                      297,029

     At $19.75 per share   (SAR)            -                               -                       20,794

     At $5.38 per share                     -                               -                       26,850

Foreign currency translation                -                               -                            -
   adjustment for 1997

Net loss for 1997                           -                               -                            -

Accrued stock appreciation rights           -                               -                     (591,915)
                                    -----------------------------------------------------------------------
Balance at December 31, 1997                -                            $  -                 $ 65,348,603
                                    =======================================================================
</TABLE>
See accompanying notes.
<PAGE>
                                  OXiGENE, Inc.
                          (a development stage company)

            Statements of Stockholders' Equity (Deficit) (continued)
                                    (Note 2)

<TABLE>
<CAPTION>
                                  Deficit Accumulated
                                      During the            Foreign Currency          Stock Subscription
                                      Development              Translation                 and Notes 
                                         Stage                  Adjustment                 Receivable
                                 -----------------------------------------------------------------------------
<S>                               <C>                       <C>                      <C>

At $7.25 per share                 $          -              $        -               $     -               

At $11.54 per share                           -                       -                     -               

At $8.95 per share                            -                       -                     -               

At $11.54 per share                           -                       -                     -               

At $15.74 per share                           -                       -                     -               

At $11.54 per share                           -                       -                     -               

At $5.38 per share                            -                       -                     -               

At $7.25 per share                            -                       -                     -               

At $13.41 per share                           -                       -                     -               

At $5.38 per share                            -                       -                     -               

At $7.25 per share                            -                       -                     -               

At prices ranging from
$25.75 to $27.00 (SAR)                        -                       -                     -               

At $5.50 per share                            -                       -                     -               

At $ 6.00 per share                           -                       -                     -               

At $6.375 per share                           -                       -                     -               

At $19.75 per share (SAR)                     -                       -                     -               

At $5.38 per share                            -                       -                     -               

Foreign currency translation                                    106,761                     -               
adjustment for 1997

Net loss for 1997                    (8,110,521)                      -                     -               

Accrued stock                                 -                       -                     -               
appreciation rights
                                ----------------------------------------------------------------------------
Balance at                         $(25,468,828)             $  219,636               $     -               
December 31, 1997
                                ============================================================================
</TABLE>
<PAGE>

                         Unrealized Losses on  for      Total Stockholders'
                           Securities Available              Equity
                                 for  Sale                  (Deficit)
                         -------------------------------------------------------

At $7.25 per share        $    -                        $    108,750

At $11.54 per share            -                             378,379

At $8.95 per share             -                             146,332

At $11.54 per share            -                              23,465

At $15.74 per share            -                             236,100

At $11.54 per share            -                           1,394,315

At $5.38 per share             -                              53,800

At $7.25 per share             -                               7,250

At $13.41 per share            -                              14,350

At $5.38 per share             -                              26,900

At $7.25 per share             -                              36,250

At prices ranging from         -                             200,216
$25.75 to $27.00 (SAR)

At $5.50 per share             -                             165,000

At $ 6.00 per share            -                              30,000

At $6.375 per share            -                             297,496

At $19.75 per share (SAR)      -                              20,805

At $5.38 per share             -                              26,900

Foreign currency               -                             106,761
translation adjustment
for 1997

Net loss for 1997              -                          (8,110,521)

Accrued stock                  -                            (591,915)
appreciation rights
                         ---------------------------------------------
Balance at                     -                        $ 40,201,269
December 31, 1997        =============================================

See accompanying notes.

<PAGE>

<TABLE>
<CAPTION>

                                  OXiGENE, Inc.
                          (A development stage company)

                      Consolidated Statements of Cash Flows

                                                                                Period from
                                                                             February 22, 1988
                                                                                (inception)
                                          Year ended December 31                  through
                                                                             December 31, 1997
                                    1995           1996            1997         (Unaudited)
                                    ----           ----            ----      -----------------
<S>                             <C>            <C>             <C>            <C>
Operating activities
Net loss                        $ (3,717,835)  $ (5,958,433)   $ (8,110,521)  $  (25,468,828)
Adjustments to reconcile net
   loss to net cash used in
   operating activities:
     Loss on  securities               9,460          2,513               -           11,973
       available-for-sale
     Depreciation                     13,773         37,153          79,244          140,466
     Abandonment of
       furniture, fixture and              -          9,041               -            9,041
       equipment
     Compensation related to
       issuance
       of warrants, options          243,720      1,035,270        (243,359)       1,463,131
       and stock appreciation
       rights
     Changes in operating
       assets and liabilities:
         Prepaid expenses and
           other                     (14,740)      (283,636)       (173,311)        (724,609)
           current assets
         Accounts payable and
           accrued expenses          146,248        185,457         370,986          993,660
                                     -------        -------         -------          -------
Net cash used in operating        (3,319,374)    (4,972,635)     (8,076,961)     (23,575,166)
   activities

Financing activities
Proceeds from investor                     -              -               -          100,000
Repayment to investor                      -              -               -         (100,000)
Proceeds from issuance and
   subscription of common          9,672,876     34,521,881       7,929,630       63,936,033
   stock, net
Other capital contributions                -         53,170               -           53,170
                                  ----------         ------       ---------           ------
 Net cash provided by              9,672,876     34,575,051       7,929,630       63,989,203
   financing activities

Investing activities
Purchases of securities                    -              -               -       (3,368,253)
   available-for-sale
Proceeds from sale of
   securities                      2,856,280        500,000               -        3,356,280
   available-for-sale
Deposits                                   -              -         (70,000)         (79,600)
Purchase of furniture,
   fixtures and equipment            (26,922)      (101,058)       (233,882)        (395,460)
                                  ----------         ------       ---------           ------
Net cash provided by (used
   in) investing activities        2,829,358        398,942        (303,882)        (487,033)
                                  ----------         ------       ---------           ------

Effect of exchange rate on            29,746        109,219          70,693          209,658
   changes in cash
                                  ----------         ------       ---------           ------

Net increase (decrease) in
   cash and cash equivalents       9,212,606     30,110,577        (380,520)      40,136,662
Cash and cash equivalents at
   beginning                       1,193,999     10,406,605      40,517,182                -
   of period
                                  ----------         ------       ---------           ------
Cash and cash equivalents at    $ 10,406,605   $ 40,517,182    $ 40,136,662      $40,136,662
                                ============   ============    ============      ===========
   end of period


See accompanying notes.
</TABLE>


<PAGE>


                                  OXiGENE, Inc.
                          (A development stage company)

                   Notes to Consolidated Financial Statements

                                December 31, 1997

1. Description of Business and Significant Accounting Policies

Description of Business


     OXiGENE,  Inc.  (the  "Company")  is  a  development  stage  pharmaceutical
company. The Company was originally  incorporated as Oxi-Gene, Inc. in the State
of New York on February 22, 1988 and subsequently recapitalized and incorporated
in the State of Delaware in December 1993.

     The Company is in the research phase of its operations.  Because operations
to-date have consisted of research  activities  only, no substantial  income has
been generated to-date and the losses sustained result  principally from outlays
for  research  and  administrative  expenses.  The  Company  may need to  obtain
additional  funding  from outside  sources to fund  operating  expenses,  pursue
regulatory approvals and build production, sales and marketing capabilities,  as
necessary.

Principles of Consolidation

     In December  1994,  the Company  established a  wholly-owned  subsidiary in
Sweden,  OXiGENE  (Europe) AB, to manage and control the Company's  research and
development  work, and monitor  European  clinical  trials.  The accounts of the
subsidiary  have  been  consolidated  from  the time  the  subsidiary  commenced
operations in January 1995. All material  intercompany balances and transactions
have been eliminated in consolidation.

Use of Estimates

     The  preparation  of financial  statements  in  conformity  with  generally
accepted  accounting  principles  requires  management  to  make  estimates  and
assumptions  that affect the amounts  reported in the financial  statements  and
accompanying notes. Actual results could differ from those estimates.



<PAGE>


1. Description of Business and Significant Accounting Policies (continued)

Depreciation

     Furniture,  fixtures and  equipment are recorded at cost.  Depreciation  is
provided using the  straight-line  method over the estimated useful lives of the
assets which is principally seven years.

Cash and Cash Equivalents

     The  Company  considers  all highly  liquid  financial  instruments  with a
maturity of three months or less when purchased to be cash equivalents.

     At  December  31,  1997,  approximately  73%  and  26%  of  cash  and  cash
equivalents were deposited in two financial institutions. Substantially all cash
and cash  equivalents  at December  31,  1996 were  deposited  in one  financial
institution.

Foreign Currency Translation

     Assets and  liabilities  of the subsidiary are translated at year-end rates
and income and expenses are  translated  at average  exchange  rates  prevailing
during the year.  Translation  adjustments  arising from differences in exchange
rates from period to period are  included in the  accumulated  foreign  currency
translation adjustments account in stockholders' equity.

Investments

     The Company  accounts for  marketable  securities  in  accordance  with the
provisions of Statement of Financial  Accounting  Standards No. 115,  Accounting
for Certain Investments in Debt and Equity Securities.



<PAGE>


1. Description of Business and Significant Accounting Policies (continued)

Patent and Patent Applications

     The  Company  has  filed   applications  for  patents  in  connection  with
technologies being developed.  The patent applications and any patents issued as
a result of these  applications are important to the protection of the Company's
technologies  that may result from its research  and  development  efforts.  The
pharmaceutical industry is highly competitive and patents may be challenged from
time to time.  The Company  intends to vigorously  defend its issued patents and
may therefore incur  significant costs in the defense of the patents and related
technologies.  Costs  associated  with the patent and  patent  applications  are
expensed as incurred.

Income Taxes

     The  Company  accounts  for  income  taxes  based  upon the  provisions  of
Statement of Financial Accounting Standards No. 109, Accounting for Income Taxes
("SFAS 109").  Under SFAS 109, the liability  method is used for  accounting for
income taxes,  and deferred tax assets and liabilities  are determined  based on
differences between financial reporting and tax bases of assets and liabilities.

Share Information

     All outstanding  share amounts  included in the  accompanying  consolidated
financial  statements have been adjusted to reflect the 10,000 for 1 stock split
disclosed in Note 2.

Unaudited Information

     Information  pertaining  to the period from  February 22, 1988  (inception)
through December 31, 1989 is unaudited.




<PAGE>


1. Description of Business and Significant Accounting Policies (continued)

Net Loss Per Share

     In 1997, the Financial Accounting Standards Board issued Statement No. 128,
Earnings per Share.  Statement 128 replaced the calculation of primary and fully
diluted  earnings per share with basic and diluted  earnings  per share.  Unlike
primary  earnings  per share,  basic  earnings  per share  excludes any dilutive
effects of options,  warrants and convertible securities.  The Company's primary
net loss per  share was  calculated  by  dividing  the net loss per share by the
weighted average number of shares  outstanding.  All options and warrants issued
by the Company were antidilutive and, accordingly, excluded from the calculation
of weighted  average  shares.  Accordingly,  Statement  128 had no effect on the
Company's net loss per share. All options and warrants were antidilutive in 1997
as well.

Stock-Based Compensation

     In October 1995, the Financial  Accounting  Standards Board ("FASB") issued
Statement of Financial  Accounting Standards No. 123, Accounting for Stock-Based
Compensation  ("SFAS  123").  SFAS 123 is effective  for fiscal years  beginning
after  December 31, 1995 and prescribes  accounting and reporting  standards for
all stock-based compensation plans, including employee stock options, restricted
stock,  employee stock purchase plans and stock  appreciation  rights.  SFAS 123
requires compensation expense to be recorded (i) using the new fair value method
or (ii) using  existing  accounting  rules  prescribed by Accounting  Principles
Board Opinion No. 25,  Accounting  for Stock Issued to Employees  ("APB 25") and
related  interpretations  with  pro  forma  disclosure  of what net  income  and
earnings  per share would have been had the  Company  adopted the new fair value
method.  The  Company  has  elected to  continue  to account for its stock based
compensation plans in accordance with the provisions of APB 25.



<PAGE>


2. Stockholders' Equity

Options and Warrants

     The following is a summary of the Company's stock option, warrant and stock
appreciation rights activity.

            Number of Options, Warrants and Stock Appreciation Rights
<TABLE>
<CAPTION>

                           Nonqualified      Stock          Stock
                          Stock Options    Incentive     Appreciation      Stock
                                            Options         Rights        Warrants
                               ------------------------------------------------------------

<S>                            <C>              <C>          <C>            <C>
Balance at December 31,        220,000          115,000       75,000        2,712,500
   1994
  Granted during 1995          664,000                -        2,000            5,000
  Exercised during 1995        (12,500)               -            -          (86,000)
  Canceled during 1995          (2,000)               -            -                -
                               -------          -------      -------       ----------
Balance at December 31,        869,500          115,000       77,000        2,631,500
   1995
  Granted during 1996          336,518           13,482            -          148,350
  Exercised during 1996        (74,000)               -      (10,000)        (998,004)
  Canceled during 1996         (20,000)               -            -                -
                               -------          -------      -------       ----------
Balance at December 31,      1,112,018          128,482       67,000        1,781,846
   1996
  Granted during 1997          316,120           19,880            -                -
  Exercised during 1997       (402,166)               -      (17,388)        (718,212)
  Canceled during 1997               -                -            -                -
                               -------          -------      -------       ----------
Balance at December 31,      1,025,972          148,362       49,612        1,063,634
1997                         =========          =======       ======        =========

</TABLE>

<TABLE>
<CAPTION>


                 Weighted Average Price of Options, Warrants and
                            Stock Appreciation Rights


                                 Nonqualified      Stock          Stock
                                Stock Options    Incentive     Appreciation      Stock
                                                  Options         Rights        Warrants
                               ------------------------------------------------------------

<S>                                 <C>          <C>                <C>         <C>         <C>
     Balance at December 31,        $  6.91      $  7.52            $6.99       $  7.11
        1994
       Granted during 1995             5.90            -             5.38          6.00
       Exercised during 1995           1.50            -                -          1.95
       Canceled during 1995            5.50            -                -             -
                                    -------      -------          -------       ----------
     Balance at December 31,           6.21         7.52             6.95          8.50
        1995
       Granted during 1996            27.69        22.13                -         10.73
       Exercised during 1996           6.46            -             6.41          7.22
       Canceled during 1996            6.00            -                -             -
                                    -------      -------          -------       ----------
     Balance at December 31,          12.75         8.95             7.03          9.60
        1996
       Granted during 1997            30.75        28.81                -             -
       Exercised during 1997           6.35            -             6.58          8.28
                                    -------      -------          -------       ----------
     Balance at December 31,
        1997                         $20.76       $11.43            $7.19        $12.63
                                     ======       ======            =====        ======
</TABLE>

<PAGE>


2. Stockholders' Equity (continued)

           Options, Warrants and Stock Appreciation Rights Exercisable

<TABLE>
<CAPTION>

                             Nonqualified    Stock          Stock
                             Stock Options  Incentive    Appreciation   Stock Warrants
                                             Options        Rights
                             ----------------------------------------------------------------

<S>                             <C>         <C>              <C>           <C>
December 31, 1994:
   Exercisable                  210,000     125,000          32,500        2,712,500
   Weighted average               $6.91       $7.52           $4.86            $7.11
    exercise price

December 31, 1995:
   Exercisable                  747,833     125,000          66,000        2,631,500
   Weighted average               $6.22       $7.52           $6.87            $8.50
    exercise price

December 31, 1996:
    Exercisable                 824,673     129,494          67,000        1,781,846
    Weighted average              $5.53       $7.01           $7.03            $9.60
   exercise price

December 31, 1997:
    Exercisable                 445,814     129,519          49,612        1,063,634
    Weighted average             $10.07       $7.01           $7.19           $12.63
   exercise price

</TABLE>

<PAGE>


2. Stockholders' Equity (continued)

           Options, Warrants and Stock Appreciation Rights Outstanding
<TABLE>
<CAPTION>

                                 Nonqualified      Stock          Stock
                                Stock Options    Incentive    Appreciation   Stock Warrants
                                                  Options        Rights
                               --------------------------------------------------------------
<S>                            <C>           <C>         <C>               <C>
December 31, 1997:
   Exercise price of
    $1.95 per share:
      Outstanding                     -      10,000               -           55,000
      Weighted average
       remaining                      -      1 year               -           1 year
       contractual life
      Exercisable                     -      10,000               -           55,000
   Exercise prices ranging
    from $5.38 per share to
    $13.69 per share:
      Outstanding               363,334     115,000          49,612        1,008,634
      Weighted average
       exercise price             $6.01       $8.00           $7.19           $13.21
      Weighted average
       remaining              7.4 years      1 year      6.78 years           1 year
       contractual life
      Exercisable               348,334     115,000          49,612        1,008,634
      Weighted average
       exercise price             $5.99       $8.00           $7.19           $13.21
   Exercise prices
    ranging from $22.00
    per share to $33.81                                           -                -
    per share:
      Outstanding               662,368      33,362               -                -
      Weighted average
       exercise price            $29.18      $26.15               -                -
      Weighted average
       remaining              9.5 years    9.7                    -                -
       contractual life                       years
      Exercisable                97,481       4,519               -                -
      Weighted average
       exercise price            $27.69      $22.25               -                -
</TABLE>

Nonqualified Stock Options

     In August  1991,  the  Company's  Board of Directors  granted  options to a
former officer of the Company to purchase 12,500 shares of the Company's  common
stock at $1.50 per share exercisable at any time prior to August 7, 2001. During
1995, such options to purchase 12,500 shares of the Company's  common stock were
exercised.



<PAGE>


2. Stockholders' Equity (continued)


     In December 1993,  under the Amended Plan, as defined below,  the Company's
Board of Directors granted options to certain directors of the Company and other
individuals to purchase  197,500  shares of the Company's  common stock at $7.25
per share.  Such options  vested at various dates over a period of one year from
the date of grant.

     In November 1994,  under the Amended Plan, the Company's Board of Directors
granted options,  subsequently  approved by stockholders in May 1995, to certain
directors of the Company and other individuals to purchase 252,000 shares of the
Company's  common stock at market value ($5.50 per share).  Such options vest at
various dates over a period of 28 months from the date of grant.

     In 1995,  under the Amended Plan, the Company's Board of Directors  granted
to certain  directors of the Company and other  individuals  options to purchase
412,000  shares of the Company's  common stock at exercise  prices  ranging from
$5.375 per share to $7.00 per share.  Options to  purchase  247,000  shares were
granted at exercise  prices  equal to the market  value of the shares on date of
grant. The remaining 165,000 shares are exercisable at $6.00 per share.  Because
the market  price of the  Company's  shares  amounted to $6.125 per share on the
date these  options were  granted,  the Company  recorded a charge for financial
reporting purposes of approximately $20,625.

     In 1996,  the  Company's  stockholders  approved  the  OXiGENE  1996  Stock
Incentive Plan (the "1996 Plan").  Certain directors,  officers and employees of
the Company and its  subsidiary  and  consultants  and  advisors  thereto may be
granted  options to purchase  shares of common stock of the  Company.  Under the
terms of the 1996 Plan,  "incentive stock options" (ISO's) within the meaning of
Section 422 of the Internal Revenue Code,  "nonqualified stock options" (NQSO's)
and stock appreciation  rights may be granted. A maximum of 1,000,000 shares may
be the subject of ISOs, NQSOs and stock appreciation rights under the 1996 Plan.

     In 1996, the Company's  Board of Directors  granted to certain  officers of
the Company and other  individuals  options to purchase 336,443 shares of common
stock at  exercise  prices  ranging  from  $22.00 per share to $28.75 per share.
Options to purchase  110,000  shares of common stock vest in equal  installments
over five years.  The remaining  options vest in equal  installments  over three
years.

<PAGE>


2. Stockholders' Equity (continued)

     In 1997, the Company's  Board of Directors  granted to certain  officers of
the Company and other  individuals  options to purchase 316,120 shares of common
stock at  exercise  prices  ranging  from  $28.81 per share to $33.81 per share.
Options to purchase  90,000  shares of common  stock vest in equal  installments
over five years.  The  remaining  options vest in equal  installments  over four
years.

Stock Incentive Options

     During 1992, the Board of Directors  implemented an Stock Incentive  Option
Plan (the "Plan").  The Plan provided for the grant of options to purchase up to
250,000  shares of common  stock to any  officer,  director  and employee of the
Company upon the terms and conditions (including price, exercise date and number
of shares)  determined by the Board of Directors or a committee  selected by the
Board of Directors to administer the Plan.

     In April 1992,  under the Plan,  the Company's  Board of Directors  granted
stock options to an officer of the Company for the purchase of 240,000 shares of
the Company's  common stock at $1.95 per share.  Such options vest at 80,000 per
year for a three-year  period.  During 1995,  vested options to purchase  80,000
shares of the Company's  common stock were  exercised.  The remaining  nonvested
options to purchase  160,000 shares of the Company's common stock were cancelled
upon the termination of the officer's services in 1994.

     On May 15, 1993, under the Plan, the Board of Directors  granted options as
compensation to certain  directors of the Company,  to purchase 10,000 shares of
common  stock at $1.95 per share,  exercisable  at any time for a period of five
years.

     During May 1993, the Company  amended and restated its Stock Incentive Plan
(the  "Amended  Plan").  Under the Amended  Plan,  the Company has  reserved for
issuance an additional 916,900 shares of Common Stock. The Amended Plan provides
for the issuance of stock appreciation rights.


<PAGE>


2. Stockholders' Equity (continued)

     Under the Amended  Plan,  the  exercise  price  determined  by the Board of
Directors  or  committee  must be at least 100% of the fair market  value of the
Company's  common  stock  as of the  date  of the  grant.  Upon  termination  of
employment,  any granted  option,  vested or unvested,  shall, to the extent not
previously  exercised,  terminate except under certain conditions as outlined in
the Amended  Plan.  The options  granted  under the Amended  Plan are  generally
exercisable at specific dates over a ten-year period.

     In December 1993,  under the Amended Plan, the Company's Board of Directors
granted stock options to a certain  director of the Company to purchase  115,000
shares  of  common  stock at $8.00  per  share.  Such  options  vested  in equal
installments on December 14, 1993 and 1994.

     In July 1996, the Board of Directors  granted  options to an officer of the
Company to  purchase  13,557  shares of common  stock at $22.13 per share.  Such
options vest in equal installments over three years.

     In April 1997, the Board of Directors  granted options to an officer and an
employee to purchase  19,880  shares of common  stock at $28.81 per share.  Such
options vest in equal installments over four years.

Stock Appreciation Rights

     Under the Amended  Plan,  the  Company's  Board of Directors  granted stock
appreciation  rights to 22,500  shares of common  stock at an exercise  price of
$7.25 per share and stock  appreciation  rights to another  22,500  shares at an
exercise  price of $5.875  per share to an  employee,  certain  consultants  and
clinical  investigators  on December  14, 1993 and April 4, 1994,  respectively.
Such stock appreciation rights vested in equal installments on December 14, 1994
and 1995.

     In  September  1994,  under the Amended  Plan,  a member of the  scientific
advisory  board received  stock  appreciation  rights to 30,000 shares of common
stock at $7.63  per  share.  Such  stock  appreciation  rights  vested  in equal
installments in September 1994, 1995 and 1996.



<PAGE>


2. Stockholders' Equity (continued)

     In  July  1995,  under  the  Amended  Plan,  a  consultant  received  stock
appreciation  rights to 2,000  shares of common  stock at $5.38 per share.  Such
stock appreciation rights vested in equal installments on July 13, 1995 and July
13, 1996.

     During 1996, stock appreciation rights to 10,000 shares were exercised when
the market value of the Company's stock exceeded the exercise price of the stock
appreciation  rights.  The Company  issued 7,039 shares of common stock upon the
exercise of such stock appreciation rights.

     During 1997,  stock  appreciation  rights to 17,388 were exercised when the
market value of the  Company's  stock  exceeded the exercise  price of the stock
appreciation  rights.  The Company  issued 13,044 shares of common stock (market
value $348,000) upon the exercise of such stock appreciation rights.

     Because the market  value per share of common  stock  exceeded the exercise
price of the stock  appreciation  rights ($10.25 on December 31, 1995 and $23.50
on December  31,  1996) the Company  recorded a charge for  financial  reporting
purposes of approximately  $223,000 (1995) and $1,035,000 (1996).  Because stock
appreciation  rights are satisfied,  upon exercise,  only by the distribution of
shares of common stock of the Company,  the charge related to unexercised  stock
appreciation rights was credited to additional paid-in capital. The market value
of the Company's common stock at December 31, 1997 was $17.50 and,  accordingly,
the charge previously recorded for financial reporting purposes was reduced by a
credit of  approximately  $592,000  in 1997 to reflect  the market  value of the
unexercised stock appreciation rights at December 31, 1997.

     Stock appreciation rights expire ten years from the date of grant.



<PAGE>


     2. Stockholders' Equity (continued)

Stock Warrants

     In November 1991, and January and June 1992, the Board of Directors granted
warrants to  directors  of the Company to  purchase  50,000,  370,000 and 50,000
shares,  respectively,  of  the  Company's  common  stock  at  $1.95  per  share
exercisable at any time for a period of five years.  In connection with the sale
of stock during  December  1992, the placement  agents were granted  warrants to
purchase 36,000 shares of the Company's stock at $1.95 per share exercisable for
a five-year  period.  In March 1995, the Board of Directors  granted warrants to
purchase 5,000 shares of common stock at $6.00 per share.  During 1995, 1996 and
1997,  warrants to purchase 86,000,  356,500 and 310,000 shares of the Company's
common stock,  respectively,  were  exercised.  In addition,  as of December 31,
1995,  $9,750 was  subscribed to exercise  warrants to purchase  5,000 shares of
common stock. Such shares were issued in 1996.

     From  January 1, 1993 through  February 26, 1993,  the Company sold 445,000
shares of common  stock to  investors  for  approximately  $868,000  ($1.95  per
share).  In connection  with this issuance of stock,  the placement  agents were
granted warrants for the purchase of 66,500 shares of the Company's common stock
at $1.95 per share exercisable for a five-year period.

     In January 1993, the Board of Directors  granted  warrants to the Company's
scientific  advisory  board to purchase  45,000 shares of the  Company's  common
stock at $1.95 per share exercisable at any time for a period of five years.

     On May 15, 1993, the Board of Directors granted warrants as compensation to
certain directors of the Company,  to purchase 180,000 shares of common stock at
$1.95 per share  exercisable at any time for a period of five years. The Company
has recorded a charge of $427,500 for financial reporting purposes, representing
the estimated value of such options and warrants granted on May 15, 1993.



<PAGE>


2. Stockholders' Equity (continued)


     During 1993, the Company  completed an initial public offering of 1,500,000
units at $6.00 per unit and an over-allotment issuance of 105,000 units at $6.00
per unit. Each unit consists of one share of the Company's  common stock and one
warrant (the "Public  Warrant").  Each warrant was  exercisable for one share of
the  Company's  common stock at a price of $7 per share during the first year of
exercisability.  Thereafter,  the exercise  price  increased each year by $2. In
connection with this offering, the Company sold to the Underwriters, for nominal
consideration,    150,000   Warrants   (the   "Underwriters'   Warrants").   The
Underwriters'  Warrants were initially  exercisable at a price of $9.90 per Unit
for a period of four years,  commencing  August 26,  1994.  The shares of common
stock and warrants issuable upon the exercise of the Underwriters'  Warrants are
identical to those included in the Units offered hereby except that the Warrants
contained in the Underwriters'  Warrants were initially  exercisable to purchase
one  share  of  Common  Stock  at  $11.55.  In  January  1996,  to  comply  with
anti-dilution provisions, the number of shares issuable upon the exercise of the
Public  Warrants  and  Underwriters'  Warrants  were  revised to  1,717,350  and
163,500, respectively. The exercise prices of such warrants were also revised to
$10.35  (subsequently  increased  to $12.35 and $14.35 in August  1996 and 1997,
respectively) and $8.95 per share,  respectively.  In addition, the total shares
of common  stock  issuable  upon the  exercise of the warrant  contained  in the
Underwriters'  Warrants  was  increased  to 172,500 and the  exercise  price was
revised to $13.69 per share.

     During the year ended  December  31,  1996,  Public  Warrants  to  purchase
502,104  shares of common stock and  Underwriters'  Warrants to purchase  65,400
shares of common stock and warrants  contained in the Underwriters'  Warrants to
purchase 69,000 shares were exercised.

     During the year ended  December  31,  1997,  Public  Warrants  to  purchase
307,412  shares of common stock and  Underwriters'  Warrants to purchase  49,050
shares of common stock and warrants  contained in the Underwriters'  Warrants to
purchase 51,750 shares were exercised.

     On December 14, 1993,  the Board of Directors  granted  warrants to certain
individuals  of the Company to purchase  10,000  shares of common stock at $7.25
per share. Such warrants vested immediately.




<PAGE>


2. Stockholders' Equity (continued)

Private Placement

     In July 1995, the Company completed a private placement of 1,666,700 common
shares at $6.00 per share,  resulting in net proceeds (after deducting  issuance
costs) of approximately $9.5 million.

Public Offering

     In November  1996,  the Company  completed a public  offering of  1,150,000
common shares at $25.2732 per share,  resulting in net proceeds (after deducting
issuance costs) of approximately $26.8 million.

Common Stock Reserved for Issuance

     As of December 31, 1997, the Company has reserved  approximately  2,600,000
shares of its common stock for issuance in connection with stock options,  stock
appreciation rights and warrants.

Recapitalization

     During December 1992, in connection with the recapitalization (see Note 1),
the Company  changed its authorized  common stock from 1,000 shares at $1.00 par
value to 5,000,000 shares at $.01 par value. In addition, the Company declared a
10,000 for 1 stock split on the then issued and outstanding common shares.

     In April  1993,  the  Company  changed  its  authorized  common  stock from
5,000,000 shares at $.01 par value to 10,000,000 shares at $.01 par value.

     In  May  1995,  the  Company  changed  its  authorized  common  stock  from
10,000,000 shares at $.01 par value to 15,000,000 shares at $.01 par value.

     In November  1996,  the Company  changed it  authorized  common  stock from
15,000,000 shares of $.01 par value to 60,000,000 shares at $.01 par value.


<PAGE>


2. Stockholders' Equity (continued)

Merger


     During February 1991, the Company issued 100,000 shares of its common stock
to an  officer/director  and a director for all the outstanding  common stock of
Bio-Screen,  Inc. The balance sheet and the cumulative  results of operations of
Bio-Screen,  Inc.  were not  material  to the  Company  and,  consequently,  the
statements of operations of the Company have not been restated.  The issuance of
the 100,000 shares, which have been recorded at par value, has been reflected as
of  August  1988,  the  date  of  inception  of  Bio-Screen,  Inc.  (see  Note 4
"Commitments").

Stock Based Compensation


     Pro forma  information  regarding  net  income  and  earnings  per share is
required by SFAS 123, and has been  determined  as if the Company had  accounted
for its  employee  stock  options and stock  appreciation  rights under the fair
value  method  of  SFAS  123.  The  fair  value  for  these  options  and  stock
appreciation  rights was  estimated  at the date of grant using a  Black-Scholes
option pricing model with the following  weighted-average  assumptions for 1995,
1996 and 1997:

          Assumption              1995        1996       1997
- ------------------------------------------------------------------

Risk-free rate                    5.8%        5.9%       5.5%
Dividend yield                     0%          0%         0%
Volatility factor of the
    expected market price of      .744        .717       .649
    the Company's common stock
Average life                     3 years    3 years     3 years


     The  Black-Scholes   option  valuation  model  was  developed  for  use  in
estimating the fair value of traded  options which have no vesting  restrictions
and are fully  transferable.  In addition,  option  valuation models require the
input of highly  subjective  assumptions  including  the  expected  stock  price
volatility.  Because the Company's employee stock options and stock appreciation
rights  have  characteristics  significantly  different  from  those  of  traded
options,  and because changes in the subjective input assumptions can materially
affect the fair value estimate,  in management's opinion, the existing models do
not  necessarily  provide a  reliable  single  measure  of the fair value of its
employee stock options and stock appreciation rights.


<PAGE>


2. Stockholders' Equity (continued)


     For  purposes of pro forma  disclosures,  the  estimated  fair value of the
options and stock  appreciation  rights is amortized to expense over the vesting
period of the options and stock  appreciation  rights.  The  Company's pro forma
information follows:

                                  1995             1996              1997
                             ---------------- ---------------- -----------------

Pro forma net loss             $(4,685,000)     $(6,836,000)     $(10,500,000)
Pro forma net loss per share         $(.80)           $(.92)           $(1.07)


     The weighted  average fair value of options  granted during the years ended
December 31, 1995, 1996 and 1997 were $3.28, $11.96 and $14.47, respectively.

3. Income Taxes

     At December 31, 1997, the Company had net operating loss  carryforwards  of
approximately  $49,800,000  for US and foreign income tax purposes,  $36,000,000
expiring for U.S.  purposes  through  2012.  The  utilization  of  approximately
$2,500,000 of such US net operating  losses are subject to an annual  limitation
pursuant to Section 382 of the Internal Revenue Code of approximately $350,000.

     Components  of the  Company's  deferred  tax asset at December 31, 1996 and
1997 are as follows:

                                               1996              1997
                                               ----              ----

     Net operating loss carryforwards    $  8,200,000       $ 18,400,000
     Compensatory stock options,
        warrants and stock appreciation
        rights                                550,000            450,000
                                           ----------        -----------
     Total deferred tax asset               8,750,000         18,850,000
     Valuation allowance                   (8,750,000)       (18,850,000)
                                           ----------        -----------
     Net deferred tax asset              $          -       $          -
                                         ============       ============


     The change in valuation allowance amounted to approximately  $1,174,000 and
$4,525,000, respectively, for the years ended December 31, 1995 and 1996.


<PAGE>


4. Commitments and Contingencies

     The Company leases premises in facilities in New York, Boston and Stockholm
and Lund, Sweden.  Rent expense for years ended December 31, 1995, 1996 and 1997
was approximately $50,000, $80,000 and $185,000, respectively.

     The minimum annual rent commitments for the above leases are as follows:

                       1998                  $156,000
                       1999                   142,000
                       2000                    81,000
                       2001                    60,000
                       2002                    15,000
                                         ===============
                                             $454,000
                                         ===============

     In  connection  with the merger  with  Bio-Screen,  Inc.  (see Note 2), the
Company obtained a license agreement to patent rights to a certain product.  The
agreement requires the Company to pay royalties,  as defined,  based on revenues
received by the Company in respect to the specified product. The license expires
in October 2011. The product has not yet been commercially developed.

     From  time-to-time the Company may be a party to litigation  arising out of
the  normal  course  of its  business.  The  Company  is and  will  continue  to
vigorously  defend  the  actions  and  claims  against  it.  In the  opinion  of
management,  these claims are either without merit or, based in part on opinions
from legal  counsel,  will not have a material  adverse  effect on the Company's
financial position.

5. Related Party Transactions

     In  September  1991,  the  Company  entered  into an  agreement  with  CATO
Research,  Ltd. ("CATO"), a North Carolina corporation,  which is majority-owned
by Dr. Cato, a consultant to the  Company's  Scientific  Advisory  Board through
January 1998 pursuant to which CATO performed preclinical and clinical planning,
development and regulatory  services in connection with the Company's efforts to
obtain FDA approval for its technology. CATO is compensated by the Company on an
hourly basis for services  actually  rendered.  For the years ended December 31,
1995, 1996, and 1997, the Company  incurred costs under this agreement  totaling
$739,994, $318,210 and $166,640, respectively.


<PAGE>


5. Related Party Transactions (continued)

     The Company has  consulting  agreements  with certain  organizations  whose
principal stockholders are officers of the Company. Consulting fees paid to such
organizations amounted to approximately  $72,000,  $336,000 and $494,000 for the
years ended December 31, 1995, 1996 and 1997.

6. Foreign Operations

     Summary financial information for assets,  liabilities at December 31, 1996
and 1997 and  expenses  for the years ended  December  31,  1995,  1996 and 1997
related to foreign operations are as follows:

                                         December 31
                            1995           1996             1997
                        ------------- --------------- -----------------

         Assets            $  240,000    $40,414,000      $40,264,417
         Liabilities          178,000        478,000          728,000
         Expenses           1,853,000      4,208,000        7,899,000
         Net loss           1,835,000      4,162,000        7,822,000


     Foreign exchange gains for the years ended December 31, 1995, 1996 and 1997
were not significant.
<PAGE>

                                   SIGNATURES

     Pursuant  to the  requirements  of  Section  13 or 15(d) of the  Securities
Exchange Act of 1934, the Registrant has duly caused this report to be signed on
its behalf by the undersigned, thereunto duly authorized.

                                             OXiGENE, INC.


                                             By:/S/ BJORN NORDENVALL
                                                      Bjorn Nordenvall
                                                      President and 
                                                        Chief Executive Officer
                                                      April 14, 1998

     Pursuant to the  requirements of the Securities  Exchange Act of 1934, this
report has been signed by the following  persons on behalf of the registrant and
in the capacities and on the dates indicated.

<TABLE>
<CAPTION>

         Signature                                  Title                                      Date
         ---------                                  -----                                      ----
<S>                                  <C>                                               <C>

/S/ BJORN NORDENVALL                  President, Chief Executive Officer               April 14, 1998
- ---------------------------           and Director (principal executive  
Bjorn Nordenvall                                    officer)
                                                   officer)

/S/ BO HAGLUND                             Chief Financial Officer                     April 14, 1998
- ---------------------------
Bo Haglund


/s/ MARVIN H. CARUTHERS                            Director                             April 14, 1998
- ---------------------------
Marvin H. Caruthers


                                                   Director                            April   , 1998
- ---------------------------
Michael Ionata


/S/ CLAUS MOLLER                                   Director                            April 14, 1998
- ---------------------------
Claus Moller


/S/ RONALD W. PERO                                 Director                            April 14, 1998
- ---------------------------
Ronald W. Pero


/S/ PER-OLOF SODERBERG                             Director                            April 14, 1998
- ---------------------------
Per-Olof Soderberg


/S/ GERALD A. EPPNER                               Director                            April 14, 1998
- ---------------------------
Gerald A. Eppner
</TABLE>
<PAGE>

                              EMPLOYMENT AGREEMENT


     This Employment  Agreement (the "Agreement") is entered into as of March 1,
1997, between OXiGENE Inc., a Delaware corporation ("OXiGENE"), and Dr. Claus J.
M0ller (the "Executive"). OXiGENE together with its subsidiary OXiGENE Europe AB
shall be referred to as the "Company."


                              W I T N E S S E T H:

     WHEREAS,  Executive  is  currently  employed by OXiGENE in the  capacity of
Executive Vice President, Marketing, Medical and Regulatory Affairs; and

     WHEREAS,  OXiGENE and Executive desire to enter into an agreement  relating
to the  continued  employment  of the  Executive  by OXiGENE for an  approximate
four-year period ending June 15, 2001.

     NOW,  THEREFORE,  for good and  valuable  consideration,  the  receipt  and
sufficiency  of which are hereby  mutually  acknowledged,  OXiGENE and Executive
hereby agree as follows:

     1. Employment

     1.1  Executive  shall  continue to serve in the capacity of Executive  Vice
President,  Marketing, Medical and Regulatory Affairs of OXiGENE, and shall have
the duties, responsibilities and authority assigned to Executive by the Board of
Directors of OXiGENE, ("Board") consistent with such position including, but not
limited to:

          (A)  responsibility with respect to the Company's clinical trials;

          (B)  responsibility  to prepare  and  present to the Board a plan with
               respect to the marketing of the Company's  products in compliance
               with government regulations;

          (C)  responsibility   to  manage  and  monitor  the  regulatory   work
               regarding  the  Company's  products,  including  maintaining  the
               contact to organizations such as FDA; and

          (D)  responsibility  to ensure proper  manufacturing  of the Company's
               product according to cGMP.

Executive  shall report  directly to  OXiGENE's  President  and Chief  Executive
Officer.

     1.2 Executive,  so long as he is employed  hereunder,  (i) shall devote his
full  professional  time and  attention  to the  services  required of him as an
employee  of  OXiGENE,  except as  otherwise  agreed  and  except  permitted  in
accordance  with paid  vacation  time  subject to  OXiGENE's  existing  vacation
policy,  and subject to OXiGENE's  existing  policies  pertaining  to reasonable
periods of absence due to sickness,  personal injury or other  disability,  (ii)
shall use his best efforts to promote the interests of OXiGENE,  and (iii) shall
discharge his  responsibilities  in a diligent and faithful  manner,  consistent
with sound business  practices.  Notwithstanding  the  foregoing,  Executive may
serve as a director of, and a  consultant  to,  IPC-Nordic  A/S,  provided  such
activity does not interfere with  Executive's  ability to perform his duties and
responsibilities hereunder.

     1.3 Executive  represents that he has resigned from his position of General
Manager of IPC-Nordic  A/S and that he holds no position  with,  and provides no
services to,  IPC-Nordic A/S other than as a director and  consultant,  it being
understood  that  such  resignation  is  a  condition   precedent  to  OXiGENE's
obligations under this Agreement.

     2. Term

     The term of Executive's  employment  under this Agreement shall commence as
of April 1,  1997,  and shall end June 15,  2001,  unless  terminated  sooner as
hereinafter provided (the "Employment Term").

     3. Base Salary; Stock Options

     3.1 OXiGENE shall pay Executive a monthly base salary during the Employment
Term of $10,000  US,  inclusive  of all income and  employment  taxes and social
costs, taxes or insurance (such amount as adjusted, from time to time, the "Base
Salary").  Executive's Base Salary shall be reviewed  annually by the Board. The
Base  Salary may be paid  deposited  directly  to an  account  in a Danish  bank
designated by Executive.

     3.2  OXiGENE  shall  grant  to  Executive,   subject  to  approval  by  the
Compensation  Committee of the Board,  pursuant to the OXiGENE  Inc.  1996 Stock
Incentive  Plan (the  "Stock  Plan"),  an option  (tegningsretter)  to  purchase
100,000 shares of common stock of OXiGENE,  $.01 par value per share,  as of the
date hereof.  Such option shall have an exercise  price equal to the Fair Market
Value (as  defined in the Stock Plan) on the date of grant of such  option,  and
shall vest and become  exercisable in four (4) equal installments of 25,000 each
on the first,  second, third and fourth anniversary of the date of grant of such
option.  The option shall be evidenced  by, and subject to, an option  agreement
having  terms  described  in the  Stock  Plan,  except to the  extent  otherwise
specified in this Agreement, including Section 6 hereof.

     3.3 Executive is solely  responsible  for the payment of any and all taxes,
costs or insurance arising in connection with Executive's employment hereunder.

     4. Benefits

     Executive shall be entitled to participate in or receive benefits under any
employee  benefit plan,  arrangement  or perquisite  generally made available by
OXiGENE  during  the  Employment  Term  to its  executives  and  key  management
employees.

     5. Business Expenses

     Executive  shall  be  entitled  to  receive  prompt  reimbursement  for all
reasonable  and  customary  expenses  incurred  by  him in  performing  services
hereunder during the Employment  Term;  provided that such expenses are incurred
and accounted for in accordance with the policies and procedures  established by
OXiGENE and approved by the Board.

     6. Termination

     6.1 OXiGENE may,  upon giving  Executive  six (6) months'  written  notice,
terminate  Executive's  employment  subject to all provisions of this Agreement.
Notwithstanding the foregoing,  OXiGENE may terminate Executive's employment for
Cause without prior notice.  Executive  may, upon giving OXiGENE six (6) months'
written  notice,   terminate  Executive's  employment  hereunder.  If  Executive
terminates  his  employment  following  a material  breach of the  Agreement  by
OXiGENE, which breach remains uncured ten (10) days after written notice thereof
is received by OXiGENE (a  "Termination  with Good Reason"),  Executive shall be
treated as if his employment was terminated by OXiGENE without Cause.

     6.2 If Executive's employment is terminated by OXiGENE other than for Cause
(as defined  below) or is a  Termination  with Good Reason,  then OXiGENE  shall
provide the following to Executive:

     (a) as  soon  as  practicable  after  the  effective  date  of  Executive's
termination of employment  ("Termination Date") a lump sum cash payment equal to
the aggregate of the following:

          (1)  the portion of  Executive's  then current Base Salary  accrued to
               the Termination  Date but unpaid as of the Termination  Date (the
               "Unpaid Salary"); plus

          (2)  an amount equal to three (3) months' Base Salary; plus

          (3)  if Executive's  termination is a Termination with Good Reason, an
               amount equal to six (6) month's Base Salary.

     (b) All stock options,  stock  appreciation  rights,  restricted stock, and
other incentive  compensation  granted to the Executive by OXiGENE shall, to the
extent vested, remain exercisable in accordance with the terms of the Stock Plan
(or prior  applicable  plan) and the agreement  entered pursuant thereto and the
Executive  may exercise all such vested  options and rights,  and shall  receive
payments and distributions accordingly.

     6.3 Except as  otherwise  set forth in this Section 6, all  obligations  of
OXiGENE under this Agreement shall cease if, during the Employment Term, OXiGENE
terminates  Executive for Cause or the Executive  resigns his  employment  other
than in a Termination with Good Reason.  Upon such termination,  Executive shall
be entitled to receive in a lump sum cash payment as soon as  practicable  after
the Termination Date an amount equal to the Unpaid Salary.

     6.4 The foregoing  payments upon Executive's  termination  shall constitute
the exclusive  payments due Executive upon  termination from his employment with
OXiGENE under this  Agreement or otherwise,  provided,  however,  that except as
stated above,  such payments  shall have no effect on any benefits  which may be
payable to Executive  under any plan of OXiGENE which  provides  benefits  after
termination  of  employment,  other than  severance  pay or salary  continuation
pursuant to an OXiGENE  plan which  amount shall be reduced by the amount of the
Severance Amount received by Executive pursuant to this Agreement.

     6.5 For the purposes of this Agreement,  the term "Cause" shall mean any of
the following:

     (a) the continued failure by Executive to perform  substantially his duties
on behalf of OXiGENE if  Executive  fails to remedy that breach  within ten (10)
days of OXiGENE's  written notice to Executive of such breach;  or (ii) material
breach  of any  other  provision  of this  Agreement  by the  Executive,  if the
Executive fails to remedy that breach within ten (10) days of OXiGENE's  written
notice to Executive of such breach; or


     (b) any act of fraud,  material  misrepresentation  or  material  omission,
misappropriation, dishonesty, embezzlement or similar conduct against OXiGENE or
any  affiliate,  or conviction of Executive for a felony or any crime  involving
moral turpitude.

     6.6 Upon  termination of Executive's  employment for any reason,  Executive
shall resign from the Board of OXiGENE, and any of its affiliates of which he is
then a  director;  such  resignations  shall be  effective  not  later  than the
effective date of termination of his employment unless otherwise mutually agreed
by Executive and the Board.

     7. No Solicitation; Confidentiality; Work for Hire

     7.1 During the Restricted Period (defined below), neither Executive nor any
Executive-Controlled  Person  (defined  below) will,  without the prior  written
consent of the Board, directly or indirectly,  solicit for employment, employ in
any capacity or make an unsolicited  recommendation  to any other person that it
employ or solicit  for  employment  any person who is or was, at any time during
the nine (9) month period prior to the Termination  Date, an officer,  executive
or key  employee  of OXiGENE or of any  affiliate  of  OXiGENE.  As used in this
Agreement,  the term  "Executive-Controlled  Person"  shall  mean  any  company,
partnership,  firm or other entity as to which Executive possesses,  directly or
indirectly,  the power to direct or cause the  direction of the  management  and
policies of such entity, whether through the ownership of voting securities,  by
contract or otherwise.

     7.2 (a) Executive  acknowledges  that, through his status as Executive Vice
President,  Marketing, Medical and Regulatory Affairs of OXiGENE and as a member
of the Board,  he has,  and will have,  possession  of  important,  confidential
information  and  knowledge  as to the  business of OXiGENE and its  affiliates,
including,  but not  limited  to,  information  related  to drugs and  compounds
developed  or  under   development  by  the  Company,   financial   results  and
projections,  future plans, the provisions of other important  contracts entered
into  by  OXiGENE  and  its  affiliates,   possible   acquisitions  and  similar
information.   Executive   agrees  that  all  such  knowledge  and   information
constitutes a vital part of the business of OXiGENE and its affiliates and is by
its nature trade secrets and confidential information proprietary to OXiGENE and
its affiliates (collectively, "Confidential Information"). Executive agrees that
he shall not, so long as the Company remains in existence, divulge, communicate,
furnish or make accessible  (whether orally or in writing or in books,  articles
or any other medium) to any individual,  firm,  partnership or corporation,  any
knowledge or information  with respect to Confidential  Information  directly or
indirectly  useful  in any  aspect  of the  business  of  OXiGENE  or any of its
affiliates. As used in the preceding sentence,  "Confidential Information" shall
not include any knowledge or information  that:  (i) is or becomes  available to
others,  other than as a result of breach by Executive of this Section 7.2; (ii)
was available to Executive on a nonconfidential basis prior to its disclosure to
Executive  through  his  status as an  officer  or  employee  of  OXiGENE or any
affiliate;  or (iii) becomes available to Executive on a  nonconfidential  basis
from a third party  (other than  OXiGENE,  any  affiliate or any of its or their
representatives)  who is not bound by any confidentiality  obligation to OXiGENE
or any affiliate.

     (b) All memoranda, notes, lists, records and other documents or papers (and
all copies  thereof),  including  such items  stored in  computer  memories,  on
microfiche or by any other means,  made or compiled by or on behalf of Executive
or made available to him relating to OXiGENE are and shall be OXiGENE's property
and shall be delivered to OXiGENE  promptly upon the  termination of Executive's
employment  with  OXiGENE or at any other time on request  and such  information
shall be held  confidential by Executive after the termination of his employment
with OXiGENE.

     7.3 As used in this  Agreement,  "Restricted  Period" shall mean the twelve
(12) months following Executive's termination of employment.

     7.4 The Executive grants the Company and each affiliate of the Company,  as
appropriate,  all rights in and to the contribution made by the Executive to any
projects or matters on which the Executive  works during the Term. The Executive
acknowledges  that each such matter and the  contribution  made by the Executive
thereto  shall  constitute a work made for hire within the meaning of the United
States copyright law and other applicable laws. The Company reserve's all rights
with respect to information relating to the Company's products,  including,  but
not limited to, the right to apply for patents.

     7.5 The  provisions  contained  in this  Section 7 as to the time  periods,
scope of activities,  persons or entities affected,  and territories  restricted
shall be deemed divisible so that, if any provision  contained in this Section 7
is determined to be invalid or  unenforceable,  such provisions  shall be deemed
modified  so as to  be  valid  and  enforceable  to  the  full  extent  lawfully
permitted.

     7.6 Executive  agrees that the  provisions of this Section 7 are reasonable
and necessary for the  protection of OXiGENE and that they may not be adequately
enforced by an action for damages and that, in the event of a breach  thereof by
Executive or any Executive-Controlled Person, OXiGENE shall be entitled to apply
for and  obtain  injunctive  relief in any court of  competent  jurisdiction  to
restrain  the breach or  threatened  breach of such  violation  or  otherwise to
enforce  specifically  such  provisions  against  such  violation,  without  the
necessity of the posting of any bond by OXiGENE. Executive further covenants and
agrees  that if he shall  violate  any of his  covenants  under this  Section 7,
OXiGENE  shall be  entitled  to an  accounting  and  repayment  of all  profits,
compensation,   commissions,  remuneration  or  other  benefits  that  Executive
directly or indirectly  has realized  and/or may realize as a result of, growing
out of or in connection with any such violation.  Such a remedy shall,  however,
be  cumulative  and not  exclusive  and shall be in addition  to any  injunctive
relief  or other  legal  or  equitable  remedy  to  which  OXiGENE  is or may be
entitled. Accordingly,  Executive agrees that he shall reimburse OXiGENE for any
reasonable  attorneys'  fees and expenses  that OXiGENE might incur in enforcing
this Section 7 if it is judicially  determined  that Executive has breached this
Section 7.

     8. Amendments

     This Agreement may not be altered,  modified or amended except by a written
instrument signed by each of the parties hereto.

     9. Assignment

     Neither this Agreement nor any of the rights or obligations hereunder shall
be assigned or delegated by any party hereto  without the prior written  consent
of the other parties; provided,  however, that any payments and benefits owed to
Executive  under  this  Agreement  shall  inure to the  benefit of his heirs and
personal representatives.

     10. Waiver

     Waiver by any party  hereto of any breach or default by any other  party of
any of the terms of this  Agreement  shall not  operate as a waiver of any other
breach or default,  whether  similar to or different  from the breach or default
waived.

     11. Severability

     In the event that any one or more of the provisions of this Agreement shall
be or become invalid,  illegal or  unenforceable  in any respect,  the validity,
legality and enforceability of the remaining  provisions  contained herein shall
not be affected thereby.

     12. Notices

     All notices and other  communications  provided for in this Agreement shall
be in  writing  and shall be deemed to have  been  duly  given  when  personally
delivered  or when  mailed by United  States  registered  mail,  return  receipt
requested, postage prepaid, addressed as follows:

                  If to Executive, to him as follows:

                  Dr. Claus J. M0ller
                  Lykkesholms Alle 31
                  DK-1902 Frederiksberg, Denmark

                  With a copy to:

                  If to OXiGENE, to it as follows:

                  OXiGENE Inc.
                  110 East 59th Street
                  New York, New York 10022
                  Attention:  M. Andica Kunst, Esq.

                  With a copy to:

                  Battle Fowler LLP
                  75 East 55th Street
                  New York, New York 10022
                  Attention:  Gerald A. Eppner, Esq.

or to such other  address or such other  person as  Executive  or OXiGENE  shall
designate in writing in  accordance  with this  Section 12,  except that notices
regarding changes in notices shall be effective only upon receipt.

     13. Headings

     Headings to  Sections  in this  Agreement  are for the  convenience  of the
parties  only and are not  intended to be a part of, or to affect the meaning or
interpretation of, this Agreement.

     14. Governing Law

     This  Agreement  shall be  governed  by the  laws of the  State of New York
without  reference to the  principles  of conflict of laws.  Each of the parties
hereto consents to the jurisdiction of the federal and state courts of the State
of New  Yorkin  connection  with any  claim  or  controversy  arising  out of or
connected with this Agreement.  Service of process in any such proceeding may be
made upon each of the parties  hereto at the address of such party as determined
in accordance with Section 12 of this Agreement, subject to the applicable rules
of the  court  in which  such  action  is  brought.  

     15. All Other Agreements Superseded

     This Agreement  contains the entire agreement between Executive and OXiGENE
with respect to all matters relating to Executive's employment with OXiGENE and,
as of the date hereof, will supersede and replace any other agreements,  written
or oral,  between the parties relating to the terms or conditions of Executive's
employment   with   OXiGENE   other   than   agreements   relating   to  options
(tegningsretter)  entered into pursuant to the Stock Plan or a predecessor  plan
of OXiGENE.

     IN WITNESS WHEREOF,  OXiGENE and Executive have caused this Agreement to be
executed as of the date first above written.



                                  _______________________________
                                  Claus J. Moller



                                  OXiGENE Inc.


                                  By: ___________________________
                                         Name:
                                         Title:



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