OXIGENE INC
DEF 14A, 1999-05-28
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                Proxy Statement Pursuant to Section 14(a) of the
                        Securities Exchange Act of 1934
                                (Amendment No. )

Filed by the Registrant [X]
Filed by a Party other than the Registrant [  ]
Check the appropriate box:
[ ] Preliminary Proxy Statement
[X] Definitive Proxy Statement
[ ] Definitive Additional Materials
[ ] Soliciting Material Pursuant to Rules 14a-11(c) or 14a-12

                                  OXiGENE, INC.
- --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)


Payment of Filing Fee (Check the appropriate box):

[X] No fee required
[ ] Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.

     1)   Title of each class of securities to which transaction applies:

                 Common Stock, $.01 par value, of OXiGENE, INC.
- --------------------------------------------------------------------------------
     2)   Aggregate number of securities to which transaction applies:

- --------------------------------------------------------------------------------
     3)   Per unit  price  or other  underlying  value of  transaction  computed
          pursuant to Exchange Act Rule 0-11: (Set forth the amount on which the
          filing fee is calculated and state how it was determined.)

- --------------------------------------------------------------------------------
     4)   Proposed maximum aggregate value of transaction:

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     5)   Total fee paid:

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[ ] Check box if any part of the fee is offset as provided by Exchange  Act Rule
0-11(a)(2)  and  identify  the  filing  for  which the  offsetting  fee was paid
previously.  Identify the previous filling by registration  statement number, or
the Form or Schedule and the date of its filing.

         1)       Amount Previously Paid:

                                       NA
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         3)       Filing Party:

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         4)       Date Filed:

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<PAGE>

[LOGO]

      ONE COPLEY PLACE, SUITE 602                  BLASIEHOLMSGATAN 2C
      BOSTON, MASSACHUSETTS 02116              STOCKHOLM, SE-111 48 SWEDEN

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON JUNE 29, 1999


TO OUR STOCKHOLDERS:

          Please take notice that the 1999 annual meeting of the stockholders of
OXiGENE, Inc., a Delaware corporation, will be held at 9:00 a.m., local time, on
Tuesday,  June 29, 1999,  at the Marriott  Hotel Copley  Place,  110  Huntington
Avenue, Boston, Massachusetts 02116, for the following purposes:

     1.   To elect seven directors to hold office until the 2000 annual meeting;

     2.   To approve and adopt  certain  amendments  to the  OXiGENE  1996 Stock
          Incentive  Plan,  including  an increase in the number of shares under
          that plan;

     3.   To ratify  the  appointment  of Ernst & Young  LLP as our  independent
          auditors for the fiscal year ending December 31, 1999; and

     4.   To transact such other business as may properly come before the annual
          meeting.

          Only  stockholders  of record at the close of  business  on the record
date,  May 7,  1999,  are  entitled  to notice  of,  and to vote at,  the annual
meeting.

                                    By Order of the Board of Directors

                                    Bo Haglund,
May 25, 1999                        Corporate Secretary

===============================================================================
YOUR VOTE IS IMPORTANT.  PLEASE  COMPLETE,  DATE, SIGN AND PROMPTLY RETURN THE
ENCLOSED  FORM OF PROXY IN THE  ENVELOPE  PROVIDED  WHETHER OR NOT YOU PLAN TO
ATTEND THE ANNUAL  MEETING.  NO POSTAGE IS REQUIRED  FOR MAILING IN THE UNITED
STATES OR  SWEDEN.  STOCKHOLDERS  WHO ATTEND  THE  ANNUAL  MEETING  MAY REVOKE
THEIR PROXIES AND VOTE THEIR SHARES IN PERSON.
===============================================================================


<PAGE>


                                TABLE OF CONTENTS

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS.................................Cover

Defined Terms................................................................i

Information Relating to the Annual Meeting...................................1

Board of Directors Meetings..................................................2

Committees...................................................................2

Compensation of Directors....................................................3

Section 16(a) Beneficial Ownership Reporting.................................3

PROPOSAL 1 -ELECTION OF DIRECTORS............................................4

Report of Compensation Committee on Executive Compensation...................7

PROPOSAL 2 -APPROVAL OF CERTAIN AMENDMENTS

             TO THE OXiGENE 1996 STOCK INCENTIVE PLAN.......................11

PROPOSAL 3 -RATIFICATION OF APPOINTMENT OF AUDITORS.........................17

Security Ownership of Certain Beneficial Owners and Management..............18

Executive Compensation......................................................19

Certain Relationships and Related Transactions..............................21

Stockholder Return Performance Graph........................................22

Other Information...........................................................23

                                  DEFINED TERMS

"OXIGENE," "WE," "US," "OUR" or "COMPANY" means,  collectively,  OXiGENE, Inc.
and its Swedish subsidiary OXiGENE Europe AB.

"PLAN" or "1996 PLAN" means the OXiGENE 1996 Stock Incentive Plan.

"NAMED  EXECUTIVE  OFFICER"  means,  collectively,  Dr.  Bjorn  Nordenvall,  our
President and Chief  Executive  Officer,  our three next highest paid  executive
officers at the end of 1998 named in the "Summary  Compensation Table" and Claus
M0ller, a former executive who ceased to be our employee on April 30, 1998.


                                       i

<PAGE>


[LOGO]

      ONE COPLEY PLACE, SUITE 602                  BLASIEHOLMSGATAN 2C
      BOSTON, MASSACHUSETTS 02116              STOCKHOLM, SE-111 48 SWEDEN

                                 PROXY STATEMENT
                                     FOR THE
                       1999 ANNUAL MEETING OF STOCKHOLDERS
                      TO BE HELD ON TUESDAY, JUNE 29, 1999
                  INFORMATION RELATING TO THE ANNUAL MEETING

PROXY STATEMENT

          OXiGENE's  Board of Directors is soliciting  proxies to be used at the
1999 annual  meeting of  stockholders.  This proxy  statement and the proxy card
will be mailed to stockholders beginning May 25, 1999.

WHO CAN VOTE

          Record  holders of our common  stock at the close of  business  on the
record date,  May 7, 1999, may vote at the annual  meeting.  On the record date,
approximately  50 record holders held  10,257,049  shares of outstanding  common
stock.

HOW YOU CAN VOTE

          You can only vote your  shares if you are either  present in person or
represented  by  proxy  at the  annual  meeting.  You can  vote  your  proxy  by
completing  and  returning  the  enclosed  proxy  card by mail.  If you return a
properly  signed  proxy card,  we will vote your  shares as you direct.  IF YOUR
PROXY CARD DOES NOT SPECIFY HOW YOU WANT TO VOTE YOUR SHARES,  WE WILL VOTE YOUR
SHARES "FOR" THE ELECTION OF ALL NOMINEES FOR DIRECTOR AND "FOR" THE APPROVAL OF
THE OTHER PROPOSALS SET FORTH IN THE NOTICE OF ANNUAL MEETING OF STOCKHOLDERS.

REVOCATION OF PROXIES

          You can revoke your proxy at any time before it is exercised by any of
these three methods:

          o      by voting in person at the annual meeting;

          o      by delivering  a written  notice of revocation dated  after the
                 proxy to our Secretary; or

          o      by delivering another proxy dated after the previous proxy.


                                       -1-
<PAGE>


REQUIRED VOTES

            Each share of common stock receives one vote on all matters properly
brought before the annual  meeting.  In order to conduct  business at the annual
meeting, a quorum,  consisting of a majority of the outstanding shares of common
stock as of the record date,  must be present in person or  represented by proxy
at the meeting. The following is an explanation of the vote required for each of
the  matters  to be voted on at the  annual  meeting:

          o    DIRECTORS. The seven nominees for director receiving the highest
               number of votes will be elected.

          o    PROPOSAL 2. The amendment to our 1996 Stock  Incentive  Plan will
               require  the  affirmative  vote  of  a  majority  of  the  shares
               represented  in person or by proxy at the  annual  meeting.  This
               means  that,  so long as a quorum is  present,  a majority of the
               votes cast at the meeting will  determine the outcome of the vote
               on this proposal.  Therefore,  the amendment could be approved by
               the  vote  of  less  than a  majority  of all of the  outstanding
               shares.

          Designated blank spaces are provided on the proxy card to mark, if you
wish either to abstain on one or more of the proposals or to withhold  authority
to vote for any nominee for  director.  Proxies  submitted by brokers who do not
indicate a vote for some or all of the items  voted on because  they do not have
discretionary  voting  authority and have not received voting  instructions  are
called  "broker  non-votes."  Abstentions  and broker  non-votes are counted for
purposes of determining  the presence or absence of a quorum.  Since our By-Laws
require the affirmative  vote of a majority of the shares present,  in person or
by proxy, an abstention on the proposals to ratify the selection of our auditors
and to increase  the number of shares under the 1996 stock  incentive  plan will
have the practical  effect of a negative vote since it represents  one less vote
for approval. With regard to the election of directors,  votes that are withheld
will be  excluded  entirely  from  the  vote and  will  have no  effect.  Broker
non-votes will not be counted for purposes of  determining  total votes cast and
thus  will  have no  effect  on the  outcome  of the  election  of the  Board of
Directors.

                           BOARD OF DIRECTORS MEETINGS

          During 1998,  the Board of Directors held seven  meetings.  Except for
Dr.  Caruthers,  attendance  by incumbent  directors at meetings of the Board of
Directors and its Committees was at least 75%.

                                   COMMITTEES

            The Board of Directors  has  established  the following two standing
committees to assist it in fulfilling its responsibilities:

AUDIT COMMITTEE

MEMBERS:                       Gerald A. Eppner (Chairman)
                               Arthur B. Laffer


                                       -2-
<PAGE>


NUMBER OF MEETINGS IN 1998:    2

FUNCTIONS:                     Reviews  the scope and timing of the  independent
                               auditors'   audit   and   other   services,   the
                               auditors'  report  on  the  Company's   financial
                               statements  following  completion  of their audit
                               and the Company's  policies and  procedures  with
                               respect  to  internal  accounting  and  financial
                               controls.

                               Makes annual recommendations to the Board of
                               Directors regarding the appointment of
                               independent auditors for the ensuing year.

COMPENSATION COMMITTEE

MEMBERS:                       Michael Ionata (Chairman)
                               Per-Olof Soderberg

NUMBER OF MEETINGS IN 1998:    6

FUNCTIONS:                     Please refer to the Report of Compensation
                               Committee on Executive Compensation below for a
                               description of the functions of the Compensation

                               Committee.

                            COMPENSATION OF DIRECTORS

          Fees.  Directors receive no cash compensation for serving on the Board
of  Directors,  other than  reimbursement  of  reasonable  expenses  incurred in
connection with meetings actually attended.

          Equity  Incentives.  Under the terms of the 1996 Stock Incentive Plan,
directors  also  receive,  upon first being  elected to the Board of  Directors,
options to purchase an  aggregate  of 55,000  shares.  The options  vest in five
equal,  annual,  cumulative  installments  of 11,000  shares each.  We intend to
change the way we  compensate  our  directors.  Please refer to Proposal 2 for a
discussion of the changes we intend to implement.

                  SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING

          Section  16(a) of the  Securities  Exchange  Act of 1934,  as amended,
requires our Directors and executive officers, and persons who own more than 10%
of our common stock,  to file with the Securities and Exchange  Commission  (the
"SEC"),  the Nasdaq  National  Market and the Company,  reports of ownership and
changes in ownership of common stock and other equity securities of the Company.
For these  purposes,  the term "other equity  securities"  would include options
granted  under our 1996 Stock  Incentive  Plan.  Based solely on a review of the
reports and representations  provided to us by the above-referenced  persons, we
believe that during 1998 all filing  requirements  applicable  to our  reporting
officers, directors and greater-than-ten percent beneficial owners were properly
and timely  satisfied,  except that Mr. Laffer and Dr. Sherris each filed late a
Form 3 (Initial Statement of Beneficial Ownership).  In making these statements,
we  have   relied   on   representations   of  our   directors,   officers   and
greater-than-ten percent beneficial owners and copies of reports they have filed
with the SEC.


                                       -3-
<PAGE>


                       PROPOSAL 1 - ELECTION OF DIRECTORS

          Information  concerning  the  nominees  for  election  to the Board of
Directors  is set  forth  below.  Each  nominee  for  election  to the  Board of
Directors  has  consented to being named as a nominee and has agreed to serve if
elected. If elected,  each Director would serve for a one-year term, expiring at
the 2000 annual meeting of stockholders. We will vote your shares as you specify
on your  proxy  card.  If you sign,  date and  return  the proxy card but do not
specify how you want your shares  voted,  we will vote them FOR the  election of
the  nominees  listed  below.  If  unforeseen  circumstances  (such  as death or
disability)  make it necessary for the Board of Directors to substitute  another
person for any of the nominees,  we will vote your shares FOR that other person.
If we do not name a substitute nominee,  the size of the Board of Directors will
be reduced.  We are not aware of any circumstances that would render any nominee
for director unavailable.

          Our Board of Directors currently consists of seven members,  including
five members who are  "non-employee  directors" within the meaning of Rule 16b-3
under the Securities Exchange Act of 1934, as amended. Each nominee for election
to the Board of Directors is currently serving as a director.

          The  following  information  with  respect  to each  nominee  has been
furnished  to the Company by that  nominee.  The ages of the  nominees are as of
March 31, 1999.

MARVIN H. CARUTHERS, PH.D.
Age:                      59

Director Since:           1996

Principal Occupation:     Professor  of  Chemistry  and   Biochemistry   at  the
                          University of Colorado, Boulder, Colorado.

Business Experience:      Scientific  co-founder  of, and a consultant to, Amgen
                          Inc.,   a   biotechnology   company   engaged  in  the
                          development  of products  derived from gene  synthesis
                          capabilities.   Scientific   co-founder   of   Applied
                          Biosystems  Inc., a  biotechnology  company engaged in
                          the  development  of  DNA   synthesizers  and  protein
                          sequencers,  which is a division  of The  Perkin-Elmer
                          Corporation.

Other Directorships:      BioStar, Inc., a biotechnology company.

GERALD A. EPPNER
Age:                      60

Director Since:           1997

Principal Occupation:     Partner, Cadwalader,  Wickersham &Taft, a New York law
                          firm  that  provides  certain  legal  services  to the
                          Company.

Business Experience:      Domestic and  international  corporate  and securities
                          law  matters.  In  private  practice  in New York City
                          since 1966, and for more than five years prior thereto
                          an employee of certain agencies and departments of the
                          United States government.

Other Directorships:      None.


                                       -4-
<PAGE>


MICHAEL IONATA
Age:                      47

Director Since:           1995
Principal Occupation:     Director  of  Corporate  Finance of  Nordberg  Capital
                          Inc.,  an  investment  banking  firm based in New York
                          City.

Business                  Experience:  Corporate  finance  and  venture  capital
                          management  at Den Norske Bank, a Norwegian  bank (May
                          1983  to  May  1991).   Specializing   in  valuations,
                          cost-benefit  analysis and restructurings at Coopers &
                          Lybrand LLP prior to May 1983.

Other Directorships:      C.E.L. Industries Poland, a restaurant company.

ARTHUR B. LAFFER
Age:                      58

Director Since:           1998

Principal Occupation:     Chairman  and  chief   executive   officer  of  Laffer
                          Associates,   an  economic   research  and   financial
                          consulting firm.

Business Experience:      Co-founder  and chairman of Calport Asset  Management,
                          an  institutional  money  management  firm.  Member of
                          President  Reagan's  Economic  Policy  Advisory  Board
                          (1980 to 1988).  Member of the  Policy  Committee  and
                          the board of  directors  of the  American  Council for
                          Capital  Formation in Washington,  D.C.  Distinguished
                          University Professor at Pepperdine  University,  and a
                          member of  Pepperdine's  board of  directors.  Charles
                          B.  Thornton  Professor  of Business  Economics at the
                          University  of  Southern  California  (1976 to  1984).
                          Associate  Professor  of  Business  Economics  at  the
                          University  of Chicago  (1970 to 1976).  Consultant to
                          the  Secretaries  of Treasury  and Defense  during the
                          years  1972-1977.  First chief economist at the Office
                          of Management and Budget under George Shultz  (October
                          1970 to July  1972,  on  leave  of  absence  from  the
                          University of Chicago).

Other Directorships:      Nicholas-Applegate  Mutual  Funds;  Nicholas-Applegate
                          Growth Equity Fund;  United States Filter Corp., a New
                          York Stock  Exchange-listed  manufacturer and operator
                          of  sewage  and  water  treatment  facilities,  MasTec
                          Inc.,  a  New  York  Stock   Exchange-listed   company
                          specializing  in  telecommunications   infrastructure,
                          and Coinmach  Corp., a Nasdaq  National  Market-listed
                          company engaged in coin-operated laundry equipment.

BJORN NORDENVALL, M.D., PH.D.

Age:                      47

Director Since:           1995

Principal Occupation:     OXiGENE's  President and Chief  Executive  Officer and
                          Chairman of the Board of Directors.

Business Experience:      General  surgeon.  President  of  Sophiahemmet  AB,  a
                          Stockholm-


                                        -5-
<PAGE>


                         based hospital (1987 to September 1996).  President  of
                         Carnegie  Medicine AB, a biotechnology  company (during
                         1983 and 1984). Practiced surgery at Danderyd Hospital,
                         Stockholm  (1977 through 1985).  Consultant to Carnegie
                         AB, a Swedish  investment banking company (1984 through
                         1986).  Consultant  to  Skandia  Insurance  Company,  a
                         Swedish insurance company, since 1984.

Other Directorships:      None.

RONALD W. PERO, PH.D.
Age:                      58
Director Since:           1988

Principal Occupation:     OXiGENE's Chief Scientific Officer.

Business Experience:      Research  with  specialty  in the field of DNA  repair
                          and  its  relation  to  cancer  treatment.   Associate
                          research  professor  (1989-1994) and adjunct professor
                          (since 1994) at New York  University  Medical  Center,
                          Department  of  Environmental  Medicine.  Professor of
                          Molecular  Ecogenetics  at the  University  of Lund in
                          Lund,  Sweden.  Member of the American  Association of
                          Science,  New York Academy of Sciences,  International
                          Preventive  Oncology  Society,  European  Society  for
                          Therapeutic    Radiation   Oncology,    The   American
                          Association   of  Cancer   Research,   and  Scientific
                          Director  of the  Board  of  Trustees  of the  Swedish
                          American Research Foundation.

Other Directorships:      None.

PER-OLOF SODERBERG

Age:                      44

Director Since:           1997

Principal Occupation:     Chief executive  officer of Dahl  International  AB, a
                          publicly-traded,   wholesale  sanitation  and  heating
                          products   company   in   Stockholm,    Sweden,    and
                          Copenhagen, Denmark.

Business Experience:      Masters  degree from  Stockholm's  School of economics
                          and  MBA  from  INSEAD,   France.  Over  twenty  years
                          business   experience,   mainly  with   wholesale  and
                          trading companies  located in Scandinavia,  including:
                          President of Dahl  International for the past 9 years,
                          a company  which has grown from a local  wholesaler to
                          the  leading  wholesaler  in its  area  with  over 250
                          affiliates  in  Denmark,   Norway,   Poland,   Sweden,
                          Estonia and Finland.

Other Directorships:      Bergman & Beving AB, a publicly-traded trading company
                          in Scandinavia; Martin Olsson, a food wholesaler based
                          in  Sweden;  and  Skandia  Investment  Management,  an
                          insurance investment company.

 UNLESS INDIVIDUAL STOCKHOLDERS INDICATE OTHERWISE, EACH RETURNED PROXY WILL BE
     VOTED "FOR" THE ELECTION TO THE BOARD OF DIRECTORS OF EACH OF THE SEVEN
                              NOMINEES NAMED ABOVE.


                                       -6-
<PAGE>


          REPORT OF COMPENSATION COMMITTEE ON EXECUTIVE COMPENSATION

INTRODUCTION

          Two  of  our  directors,   Mr.  Ionata  (Chairman)  and  Mr.  Per-Olof
Soderberg, each of whom is a non-employee director,  constitute the Compensation
Committee.  The Compensation  Committee,  among other things, is responsible for
making  recommendations  to the Board of  Directors  with  respect  to:

          (1)  the compensation  philosophy and compensation  guidelines for our
               executives;

          (2)  the  role  and  performance  of each of our  executive  officers,
               especially as these affect compensation;

          (3)  appropriate  compensation  levels for our Chief Executive Officer
               and  other   executives   based  on  a   comparative   review  of
               compensation practices of similarly situated businesses; and

          (4)  the design and  implementation of our compensation  plans and the
               establishment of criteria and the approval of performance results
               relative to our incentive  plans. An important  consideration  in
               respect of all these criteria is our overriding  desire to retain
               cash and to compensate our managers in stock,  which also has the
               effect of  aligning  their  interests  with the  interest  of the
               stockholders.

          As  a  practical  matter,  the  Committee  sets  and  administers  all
compensation of our management  directors,  Drs.  Nordenvall and Pero, since the
management  directors do not participate in  deliberations  regarding or vote on
compensation  matters  affecting  them. The Board of Directors did not modify or
reject any action or  recommendation  of the  Compensation  Committee  regarding
compensation for the 1998 fiscal year.

          This report sets out the Company's executive  compensation  philosophy
and objectives,  describes the components of our executive  compensation program
and describes the bases on which 1998 executive compensation determinations were
made with  respect  to our  executive  officers,  including  those  named in the
Summary Compensation Table following this report.

EXECUTIVE COMPENSATION PHILOSOPHY AND OBJECTIVES

          It is our policy to maintain a flexible  managerial  and  compensation
structure so that we may continue to meet our evolving and changing  supervisory
needs,  while  tightly  controlling  our  overhead  expenses,  as  our  business
progresses.  As part of this policy,  we provide a compensation  package that is
intended to focus executive  behavior on the fulfillment of annual and long-term
business  objectives,  and to create a sense of  ownership  in the Company  that
causes  executive  decisions  to be  aligned  with  the  best  interests  of our
stockholders.  We also recognize that  competition in our markets is strong both
for obtaining and retaining high quality executives and key employees,  and that
we  must  meet  the  standards  of the  marketplace  if we are  to  fulfill  our
managerial and employee goals.


                                       -7-
<PAGE>


          In 1998,  total  cash  remuneration  arrangements  with the  Company's
executive officers serving from time to time amounted to approximately $950,000.
Unlike advisory board members and directors,  the Company traditionally has paid
remuneration  to  certain  consultants  largely  in cash,  even  those who often
perform  functions  that  are  customarily  associated  with  executive  officer
positions.  The amount of cash remuneration  payable to consultants is likely to
vary from time to time  depending on our  activities,  including the progress of
our clinical trials.  As our clinical trials continue to progress and expand and
we prepare to file one or more new drug applications with the United States Food
and Drug  Administration and similar government  authorities in other countries,
we will evaluate the need to hire more full-time executives and key employees.

COMPENSATION PROGRAM COMPONENTS

          Consistent with our executive  compensation  objectives,  compensation
for the senior  managers  consists  of two  elements:  an annual base salary and
long-term incentive compensation.

          Annual  Base  Salary.   Base  salaries  for  executive   officers  are
determined with reference to a salary range for each position. Salary ranges are
determined by evaluating a particular  employee's position and comparing it with
what are believed to be representative prevailing norms for similar positions in
similarly-sized  companies.  Within this salary range,  an  executive's  initial
salary level is determined largely through Compensation Committee judgment based
on our experience.  Salaries are determined at a level to attract,  motivate and
retain superior executives.  We determine annual salary adjustments based on the
Company's  performance,   the  individual   executive's   contribution  to  that
performance, prevailing norms and our knowledge and experience.

          Long-Term Incentive Compensation.  Long-term incentive compensation is
provided  by the grant of options to purchase  shares of common  stock under the
Company's stock incentive  plans(s).  In considering  awards,  the  Compensation
Committee  takes into account such factors as prevailing  norms for the ratio of
options  outstanding to total shares  outstanding,  the relative  influence each
position will have on the building of stockholder  value over the long term, and
the  amount,  vesting  and  expiration  dates  of each  executive's  outstanding
options. We look at each executive's total compensation package and, taking into
account  our desire to  minimize  cash  outlays  as a matter of policy  based on
fiscal  prudence,  we expect our  executives  and key  employees  to look at the
incentive  compensation  component  as being the  predominant  feature  of their
overall compensation  package. This policy is in contrast to that of a number of
other biopharmaceutical companies.

          Consultant's  Compensation.  The Company  continues to rely to a great
extent on consultants,  including,  among others,  the members of our Scientific
Advisory Board and the  newly-established  Clinical Trial Advisory Board, in the
areas of research and development, clinical trials and clinical trial management
and  marketing.  We believe that, at least  presently,  it is less expensive and
more  efficient  to  engage  consultants  rather  than to expand  the  Company's
overhead by hiring  individuals  for these  positions.  In order to retain their
motivation and long-term commitment, and in order to conserve cash, from time to
time  these  consultants  will be  granted  options  under the  Company's  stock
incentive plan(s). Indeed, as a matter of policy, we


                                       -8-
<PAGE>


currently are moving in the direction of increasing the relative  portion of our
consultants'  compensation that is comprised of equity  interests,  particularly
stock options.

          Other.  Based on currently  prevailing  authority,  including proposed
Treasury regulations, and in consultation with outside tax and legal experts, we
have determined that it is unlikely that we would require the Company to pay any
amounts in 1999 that would result in the loss of a federal  income tax deduction
under  Section  162(m) of the  Internal  Revenue Code of 1986,  as amended,  and
accordingly we have not  recommended  that any special actions be taken or plans
or programs be revised at this time in light of such tax provisions.

REPRICING OF OPTIONS

          Equity  incentives  have always been a significant  component  and, in
some cases, the sole component, of our compensation package for a broad range of
our  employees,  directors  and  consultants.  This  practice  has enabled us to
attract, retain and motivate experienced and dedicated employees,  directors and
consultants  to achieve and continue our  long-term  objectives.  By linking key
parts of their compensation to corporate performance, an employee's,  director's
or consultant's reward is directly related to our success. We believe the use of
equity incentives increases motivation to improve stockholder value.

          Some  consultants,  including some members of our Scientific  Advisory
and Clinical Trial Advisory Boards,  and our non-employee  directors,  including
the  undersigned  members  of  the  Compensation  Committee,   receive  no  cash
compensation at all. Their compensation has consisted entirely of stock options.
As we approached  year-end 1998, however, we recognized that, as a result of the
decline in our stock price,  the  effectiveness  of our  equity-based  incentive
program had diminished.  We concluded that previously  granted options no longer
had any retention  value and that we were at risk of losing persons  critical to
our success. We believed this situation was particularly serious in light of the
time and resources  expended  over the past three years in putting  together our
current  management  team and  both  the  experience  they  had  gained  and the
dedication  to the Company they had  evidenced  over that  period.  We believed,
therefore,  that a repricing  was  necessary to provide the  intended  incentive
value that is a fundamental part of our compensation policy.

          Accordingly,  we retained the Hay Group, a  Boston-based  compensation
consulting  firm, to advise us regarding this matter,  and on December 14, 1998,
in accordance with the Hay Group's report,  we offered to reprice  approximately
720,000  options,   representing  less  than  6%  of  our  fully-diluted  shares
outstanding.  Of the  720,000  options  that we offered to  reprice,  41.7% were
options previously granted to executive officers,  38.2% were options previously
granted to non-employee  directors and 20.1% were options  previously granted to
certain consultants.

          In adopting the repricing,  we were of the view that we were balancing
and  aligning  our  incentive  and  retention   goals  with  your  interests  as
stockholders. For example, the options were not merely repriced, but we added an
additional  one-year  vesting  period to options that had already  vested and an
additional year was added to the vesting  schedule of those options that had not
already vested. As a result,  the services of the option recipients were assured
for a longer  period.  Further,  options were repriced  using an exchange  ratio
under which fewer


                                       -9-
<PAGE>


repriced  (lower  priced) new options  were  received in exchange for the higher
priced,  old options  that were  canceled.  As a result,  fewer  options are now
outstanding,  which  reduces  current  dilution.  In addition,  by repricing the
options  on  the  basis  of  the  Black-Scholes  economic  exchange  method,  as
recommended by the Hay Group, we concluded that the optionholders were not being
given any greater value indeed, by using the Black-Scholes method, the values of
the old and the newly repriced  option  packages were equal.  Further,  you, our
stockholders,  received  added  value  in  the  form  of an  expectation  of the
Company's  ability to better retain key persons with  increased  incentives  for
them to create  stockholder  value.  Finally,  the  options of our  non-employee
directors were repriced to reflect a new option exercise price that was actually
higher than the then open-market price of our common stock,  which resulted in a
premium for the Company over the then fair market value of the options.

          The table below provides  information with respect to the repricing of
options held by the named executive  officers,  other than Dr. Claus M0ller, who
ceased to be an  executive  officer  on April 30,  1998,  and Dr.  Sherris,  who
declined to have his options repriced.

          All  options  were  repriced  on  December  14,  1998.   Employee  and
consultant  options  were  repriced  with a new exercise  price of $8.9375,  the
closing  price of our common stock on December 14, 1998.  Non-employee  director
options were repriced to $10.00,  which,  as noted above,  reflected a more than
10%  premium in favor of the Company  over the then  market  price of the common
stock. We have never before repriced any options and do not have any plans to do
so further in the future.

                                                                     LENGTH OF
                   NUMBER OF SHARES     MARKET                       ORIGINAL
                  UNDERLYING OPTION     PRICE    EXERCISE            OPTION TERM
                 -------------------   OF STOCK  PRICE AT    NEW     REMAINING
                  BEFORE    AFTER       AFTER    TIME OF   EXERCISE   AT DATE
     NAME        REPRICING REPRICING  REPRICING  REPRICING PRICE(1) OF REPRICING
- --------------------------------------------------------------------------------

Bjorn Nordenvall,  165,000  120,053    $8.9375    $30.25    $8.9375   7 years,
President and CEO                                                     182 days

Ronald Pero,       60,000   46,821     $8.9375    $28.8125  $8.9375   8 years,
Chief Scientific                                                      137 days
Officer

Bo Haglund,        30,000   24,253     $8.9375    $22.00    $8.9375   7 years,
Chief Financial                                                       241 days
Officer

- ------------
(1) Represents market price on date of repricing.

                                          RESPECTFULLY SUBMITTED,
                                          THE COMPENSATION COMMITTEE

                                          Michael Ionata (Chairman)
                                          Per-Olof Soderberg


                                      -10-


<PAGE>

                 PROPOSAL 2 - APPROVAL OF CERTAIN AMENDMENTS TO

                      THE OXIGENE 1996 STOCK INCENTIVE PLAN

          We are also asking you to approve  certain  amendments  to the OXiGENE
1996 Stock  Incentive  Plan. The  amendments  provide for (1) an increase in the
number of shares  available under the Plan from 1 million  shares,  as presently
constituted,  to 1.5 million shares, as proposed, an increase of 500,000 shares,
and (2) a change in the compensation  formula for our non-employee  directors as
described below. As of the date of this proxy statement,  awards with respect to
816,460  shares have been made under the Plan. As a result,  only  approximately
174,000  shares  remain  available for the grant of options in the future if the
proposed amendment to the Plan is not approved.  The closing price of our common
stock as reported on the Nasdaq  National Market on May 11, 1999, was $10.50 per
share.

          In  connection  with the  December  1998  repricing  described  in the
Compensation  Committee's  report,  we  retained  the Hay  Group to assist us in
undertaking a comprehensive review of our compensation policy and practices. The
fundamental  objective of our  compensation  policy  remains the  attraction and
retention  of highly  qualified  persons to serve as  directors,  officers,  key
employees and consultants.  This objective is balanced against,  and is strongly
influenced  by, our need to  preserve  our cash  resources.  Therefore,  we have
traditionally  considered options and other equity incentives to be an important
element of our overall  compensation  philosophy.  In that regard,  however,  we
recognize that, while options may have substantial upside potential, their value
and,  therefore,  their ability to attract and retain  personnel,  is inherently
uncertain.

          In comparing our compensation practices to those of a peer group of 18
small biotech/pharmaceutical companies specializing in cancer-related areas (the
"peer group"),  who were  identified for us by the Hay Group,  we found that our
directors, officers and consultants were compensated below the mean compensation
level of the peer group. As a result, and based on the advice and recommendation
of our outside  consultants,  we have concluded that we should amend our plan to
change the compensation package of our non-employee directors as follows:

          Non-employee  directors will be granted options as follows:

          o    Initial Option Grant Upon First Election to Board: Options with a
               Black-Scholes  value of approximately  $150,000  (measured at the
               time of grant),  vesting over five years and  exercisable  at the
               market  price in  effect  on the date of grant  (currently,  this
               would  result  in  an  initial  grant  of  approximately   29,000
               options); and

          o    Annual Option Grant: On each anniversary thereafter, options with
               a  Black-Scholes  value  of  about  $35,000,  containing  similar
               vesting and pricing terms.

          The foregoing  does not affect our incumbent  directors,  none of whom
will receive  initial  options in accordance  with the foregoing.  Following the
1999 annual meeting, our incumbent directors,  however,  will receive additional
options as described  below and,  thereafter,  may receive  annual  options only
after the fifth anniversary of the granting of the options described below.


                                      -11-
<PAGE>


          In addition, we intend to change the manner in which we compensate our
executive  employees  as follows.  At the end of each year,  we will compare the
amount of compensation  actually received by each of our executive  employees to
that received by similarly  positioned  executive  employees of companies in the
75th  percentile of our peer group.  To the extent our  executive  employees are
paid less than those of the peer group companies, we will take the dollar amount
of such difference (the  "differential")  and will grant the executive an option
to  purchase  a number of shares  that will be  determined  by the  Compensation
Committee.  The  number of shares  subject  to that  option  will not exceed the
dollar amount of the  differential.  To calculate  the maximum  number of shares
that may be the subject of such an option, we will use the Black-Scholes  method
based on the stock price on the date of grant.  As  previously  noted,  however,
executive  employees  will not  automatically  receive an option to purchase the
maximum  number  of  shares.  Instead,  the  actual  number of  options  will be
negotiated  with  each  individual  executive  employee  based  on  his  or  her
performance and his or her contribution to the Company. We intend to examine our
executive employees' 1998 compensation arrangements and to compare them with the
arrangements  of their  counterparts  at  companies  in our peer group  promptly
following the 1999 annual meeting.  We will then grant  additional  options,  in
accordance with the formula described above, if appropriate.

          In order to bring our incumbent non-employee directors to a level that
we believe fairly reflects their position relative to that of their counterparts
in the peer group companies,  we intend to make a one-time grant as set forth in
the following table.

            DIRECTOR                    ADDITIONAL OPTIONS
            --------                    ------------------

            Marvin Caruthers            18,623

            Michael Ionata              18,623

            Gerald Eppner               10,856

            Per-Olof Soderberg          10,856

            Arthur Laffer                 7,467

          Consequently,  we  are  proposing  that  each  incumbent  non-employee
director  will  have  five-year  options  for an  aggregate  of  60,000  shares,
including the new options reflected in the above table that cover for all of our
incumbent  non-employee  directors an aggregate of 66,425 shares.  These options
will have an  exercise  price of $10.50,  which  represents  a  slightly  higher
premium  over the market price on the date of grant than the premium over market
used for the repricing of the non-employee directors options in December 1998.

          We are requesting that you approve the amendments to the Plan in order
that the Company may have sufficient  shares  available for the grant of options
in the future.  We believe the  increased  number of shares we are asking you to
approve are necessary for the Company to be able to attract and retain executive
officers and key employees, directors and consultants,  including as a result of
the  implementation  of the new program  described  above,  while continuing the
Company's policy of conserving its cash resources.

          Accordingly, the Board of Directors adopted the amendments to the Plan
effective May 6, 1999, subject to stockholder approval.  The affirmative vote of
the holders of a majority


                                      -12-
<PAGE>


of the  shares  represented  in  person  or by proxy at the  annual  meeting  is
required to approve the  amendment  to the Plan.  As a result,  abstentions  and
broker non-votes will have the same effect as negative votes. Below is a summary
of the principal  provisions of the Plan and its  operation.  A copy of the Plan
was filed as an exhibit to our proxy  statement for our 1996 annual  meeting and
is  available  on the  SEC's  web  site  at  http://www.sec.gov.  The  following
description  of the Plan is  qualified  in its  entirety  by  reference  to that
exhibit.

   THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" APPROVAL OF THE AMENDMENT TO
                      THE OXIGENE 1996 STOCK INCENTIVE PLAN

SHARES SUBJECT TO PLAN  Awards with respect to a maximum of 1,500,000  shares of
                        common  stock may be made  under the Plan,  as  amended.
                        Of that number of shares,  the proposed  amendment would
                        add 500,000  shares to the  1,000,000  shares  initially
                        approved,  of which only  approximately  174,000  remain
                        available  for the  grant of new  options.  No  employee
                        may  be  granted  options  or  free-standing  SARs  with
                        respect  to more than  500,000  shares of common  stock.
                        That  number of shares may be  adjusted  in the event of
                        certain changes in the capitalization of the Company.

PLAN ADMINISTRATION     The Plan is  administered by a committee of at least two
                        "non-employee  directors"  within  the  meaning  of Rule
                        16b-3  under the  Securities  Exchange  Act of 1934,  as
                        amended,  and "outside  directors" within the meaning of
                        Section  162(m) of the  Code.  The  committee  will have
                        authority,   subject  to  the  terms  of  the  Plan,  to
                        determine  when  and to whom to make  grants  under  the
                        Plan,  the number of shares to be covered by the grants,
                        the types and terms of  options  and SARs  granted,  the
                        exercise  price of the shares of common stock covered by
                        options  and SARs and to  prescribe,  amend and  rescind
                        rules  and   regulations   relating  to  the  Plan.  New
                        options granted to  non-employee  directors are governed
                        by the formula discussed below.

ELIGIBILITY             Certain   of   our   directors,   officers,   employees,
                        consultants  and  advisors  may be  granted  options  to
                        purchase   shares   of  our   common   stock   or  stock
                        appreciation  rights ("SARs") under the Plan. The number
                        of persons  eligible to receive awards under the Plan is
                        not presently determinable.

TRANSFER OF AWARDS      Generally,  awards  may not be  transferred  to  another
                        person  except  by  will  or the  laws  of  descent  and
                        distribution.   In   addition,   options  that  are  not
                        incentive  stock  options  may  be  transferred  by  the
                        holder to the holder's children, grandchildren,  spouse,
                        one or more  trusts  for  the  benefit  of  such  family
                        members or a corporation  (including a limited liability
                        company) or partnership  (including a limited


                                       -13-
<PAGE>


                        liability  partnership)  in which such  family  members
                        and/or the holder are the majority shareholders, members
                        or partners; provided, however, that the holder may  not
                        receive any consideration for the transfer.

TERMINATION             Options  expire ten years from the  option  grant  date,
                        except that an "incentive  stock  option"  granted to an
                        employee  who is the  holder  of 10% of our  outstanding
                        shares expires five years from the option grant date.

DIRECTOR OPTIONS        Following the 1999 annual meeting,  each director who is
                        not an employee of the Company  will be granted  options
                        as  follows:  (1) upon  his  first-time  election to the
                        Board,  an  option  with a then  Black-Scholes  value of
                        $150,000;  and (2) at each succeeding anniversary of his
                        election  on which he  remains  a  director,  an  option
                        having a then  Black-Scholes  value of $35,000.  The per
                        share  exercise  price of an option will be equal to the
                        fair  market  value  of a share of  common  stock on the
                        date such  option is  granted.  Each  option  will vest,
                        and be  exercisable,  in five equal annual  installments
                        on each  anniversary  of the date of grant,  subject  to
                        the  power  of the  Compensation  Committee  to vary the
                        vesting   arrangement  to  meet  the  tax  needs  of  an
                        individual  recipient if such  variance  does not change
                        the  substance  of  the  arrangement  set  forth  herein
                        insofar as it affects the Company.

EMPLOYEE OPTIONS        Under  the  Plan,  "incentive  stock  options"  ("ISOs")
                        within  the  meaning  of  Section  422 of  the  Internal
                        Revenue Code,  "nonqualified  stock  options"  ("NQSOs")
                        and SARs may be granted by the  committee  to  employees
                        of  the  Company  and  any  of  its  affiliates  and  to
                        consultants and service  providers to the Company or any
                        present or future  Affiliate  Companies  (as  defined in
                        the  Plan),  except  that  ISOs may be  granted  only to
                        employees  of the Company  and any of its  subsidiaries.
                        The per share purchase  price (or "option  price") under
                        each option is  established by the committee at the time
                        the option is  granted.  However,  the per share  option
                        price  of an ISO  granted  to a  participant  must be at
                        least  100% of the fair  market  value of a share on the
                        date  the ISO is  granted  (110%  in the  case of an ISO
                        granted to a holder of 10% of our  outstanding  shares).
                        Options  will be  exercisable  at such times and in such
                        installments   as  determined  by  the  committee.   The
                        committee  may  accelerate  the  exercisability  of  any
                        option at any time.

EXERCISABILITY          Options  generally may not be exercised  more than three
                        months  after  the  option   holder  ceases  to  provide
                        services to the Company or an affiliate,  except that in
                        the   event  of  the  death  or   permanent   and  total
                        disability  of the  option  holder,  the  option  may be
                        exercised by the holder (or the holder's estate),  for a
                        period  of up to one  year  after  the



                                       -14-
<PAGE>


                        date of death or  permanent  and total  disability.  The
                        agreements evidencing the grant of an option (other than
                        an  option  to a  non-employee  director)  may,  in  the
                        discretion  of the  committee,  set forth  additional or
                        different terms and conditions applicable to such option
                        upon a termination or change in status of the employment
                        or   service   of  the   optionee.   Options   terminate
                        immediately   if  the  option   holder's   service   was
                        terminated for cause.

PAYMENT OF EXERCISE     The  shares  purchased  upon the  exercise  of an option
PRICE                   must be paid  for in cash  (including  cash  that may be
                        received  from the  Company at the time of  exercise  as
                        additional  compensation)  or through  the  delivery  of
                        other  shares of Common  Stock with a value equal to the
                        total Option Price or in a combination  of cash and such
                        shares,   subject  to  the  power  of  the  Compensation
                        Committee  to vary the  payment  arrangement,  including
                        delivery of a  non-recourse  note, to meet the tax needs
                        of an  individual  non-U.S.  recipient if such  variance
                        does not change the  substance  of the  arrangement  set
                        forth  herein  insofar as it affects  the  Company..  In
                        addition,  the option  holder may have the Option  Price
                        paid by a broker or dealer  and the shares  issued  upon
                        exercise of the option delivered  directly to the broker
                        or dealer.

STOCK APPRECIATION      The  committee  also may grant SARs either  alone ("free
RIGHTS                  standing  rights") or in  conjunction  with some or part
                        of an option ("related rights"). Upon the exercise of an
                        SAR  a  holder  is  entitled,  without  payment  to  the
                        Company,  to receive cash, shares of common stock or any
                        combination thereof, as determined by the committee,  in
                        an amount  equal to the excess of the fair market  value
                        of one share of common stock over the exercise price per
                        share specified in the related option (or in the case of
                        a free standing right,  the price per share specified in
                        such  right),  multiplied  by the  number  of  shares of
                        common stock in respect of which the SAR is exercised.

AMENDMENT OR            Our Board of  Directors  has the power to  terminate  or
TERMINATION             amend  the Plan at any time.  If the Board of  Directors
                        does not take action to earlier  terminate  the Plan, it
                        will terminate on March 11, 2006. Certain amendments may
                        require  stockholder  approval,  and  no  amendment  may
                        adversely  affect  options  that  have  previously  been
                        granted.

PLAN BENEFITS           All incumbent  non-employee  directors have been granted
                        director  options  under the Plan.  Such options cover a
                        total of  233,576  shares  (after  giving  effect to the
                        December 1998  repricing)  and have an exercise price of
                        $10.00 per share. Messrs.  Nordenvall,  Pero and Haglund
                        have  received  options  with  respect  to  a  total  of
                        191,127  shares  (after  giving  effect to the  December
                        1998 repricing),  all of which have an exercise price of
                        $8.9375.  Dr.  Sherris was granted  options with respect
                        to 45,000  shares,  at an  exercise  price of $12.00



                                       -15-
<PAGE>


                        per share,  upon  commencement  of his employment in May
                        1998. Dr. Sherris declined to have his options repriced.


FEDERAL INCOME TAX CONSEQUENCES RELATING TO OPTIONS

          The  following is a general  discussion  of certain  U.S.  federal tax
consequences  relating  to the  exercise of options.  This  discussion  does not
address all aspects of U.S. federal taxation,  does not discuss state, local and
foreign tax issues and does not discuss  considerations  applicable  to a holder
who is, with respect to the United States, a non-resident alien individual. This
summary of federal income tax  consequences  does not purport to be complete and
is based upon  interpretations  of the existing  laws,  regulations  and rulings
which could be  materially  altered with  enactment of any new tax  legislation.
Further,  this discussion does not address the Swedish tax consequences relating
to options and the exercise  thereof;  such  consequences  affect certain of the
Company officers, directors, key employees and consultants.

          In general,  an optionee  will not recognize  taxable  income upon the
grant or exercise of an ISO,  and the  Company  and its  subsidiary  will not be
entitled to any business expense deduction with respect to the grant or exercise
of an ISO. (However,  upon the exercise of an ISO, the excess of the fair market
value on the date of exercise of the shares  received over the exercise price of
the shares  will be treated as an  adjustment  to  alternative  minimum  taxable
income.) In order for the exercise of an ISO to qualify for this tax  treatment,
the  optionee  generally  must be an employee  of the Company or its  subsidiary
(within the meaning of Section 422 of the Code) from the date the ISO is granted
through the date three months  before the date of exercise  (one year  preceding
the  date of  exercise  in the  case of an  optionee  who is  terminated  due to
disability).  In addition, an option will not be treated as an ISO to the extent
that the fair  market  value of stock with  respect  to which ISOs first  become
exercisable during any calendar year exceeds $100,000.

          If the optionee has held the shares  acquired  upon exercise of an ISO
for at least two years  after the date of grant and for at least one year  after
the date of exercise,  when the optionee disposes of the shares, the difference,
if any,  between  the sales  price of the shares and the  exercise  price of the
option  will be treated  as  long-term  capital  gain or loss.  If the  optionee
disposes of the shares prior to satisfying these holding period  requirements (a
"disqualifying disposition"), the optionee will recognize ordinary income at the
time of the  disqualifying  disposition,  generally  in an  amount  equal to the
excess  of the fair  market  value of the  shares  at the  time the  option  was
exercised  over the  exercise  price of the  options.  The  balance  of the gain
realized,  if any, will be long-term or short-term capital gain,  depending upon
whether  or not the  shares  were sold more than one year  after the  option was
exercised. If the optionee sells the shares in a disqualifying  disposition at a
price  below the fair  market  value of the  shares at the time the  option  was
exercised,  the amount of ordinary income will be limited to the amount realized
on the  sale  over  the  exercise  price  of the  option.  The  Company  and its
subsidiary  will be  allowed a  business  expense  deduction  to the  extent the
optionee recognized ordinary income.

          In general, an optionee who receives a non-qualified stock option will
recognize no income at the time of the grant of the option.  Upon  exercise of a
non-qualified  stock option,  an optionee will recognize  ordinary  income in an
amount equal to the excess of the fair market value of the shares on the date of
exercise  over the exercise  price of the option.  The  optionee's


                                       -16-
<PAGE>


tax basis in shares acquired upon exercise of a non-qualified  stock option will
be the fair market value on the date income is  recognized,  and the  optionee's
holding period will commence on that date.  The Company and its subsidiary  will
be entitled to a business  expense  deduction in the same amount and at the same
time as the optionee recognizes ordinary income.

          PROPOSAL 3 - RATIFICATION OF APPOINTMENT OF AUDITORS

          Our Audit Committee has appointed Ernst & Young LLP as our independent
auditors for the fiscal year ending  December  31,  1999.  Ernst & Young LLP has
audited our financial statements since 1992.

          Stockholder  ratification  of the  appointment of Ernst & Young LLP as
our independent  auditors is not required by our By-Laws or otherwise.  However,
we are submitting the appointment of Ernst & Young LLP to the  stockholders  for
ratification as a matter of what we consider to be good corporate  practice.  If
the stockholders fail to ratify the appointment,  we will reconsider  whether or
not to retain  that firm.  Even if the  appointment  is  ratified,  our Board of
Directors,  in  its  discretion,  may  direct  the  appointment  of a  different
independent  accounting firm at any time during the year if they determines that
such  a  change  would  be  in  the  best  interests  of  the  Company  and  its
stockholders.

          Representatives of Ernst & Young LLP are expected to be present at the
annual  meeting,  will have an opportunity to make a statement if they so desire
and will be available to respond to appropriate questions from stockholders.

       THE BOARD OF DIRECTORS RECOMMENDS A VOTE "FOR" RATIFICATION OF THE
   APPOINTMENT OF ERNST & YOUNG LLP AS THE INDEPENDENT AUDITORS FOR THE FISCAL
                         YEAR ENDING DECEMBER 31, 1999.


                                       -17-
<PAGE>


         SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

          The table below shows how many  shares of common  stock each  Director
and each named executive  officer and the Directors and executive  officers as a
group  beneficially  owned as of April 9, 1999.  Except as otherwise noted, each
person  listed in the table owns all  shares  directly  and has sole  voting and
investment power.

                                             SHARES SUBJECT TO
                                            OPTIONS INCLUDED IN
          NAME(1)            NO. OF SHARES         TOTAL           % OF TOTAL

Ronald W. Pero                 690,000(2)        260,000               6.59%
Bjorn Nordenvall               402,570(3)        165,000(4)            3.88%
Per-Olof Soderberg             120,220(5)              -               1.17%
Claus M0ller                   129,400            73,334               1.26%
David Sherris                    1,000                 -                *
Bo Haglund                           0                 -                *
Michael Ionata                   5,000             5,000(6)             *
Marvin H. Caruthers              1,500(7)              -                *
Arthur B. Laffesr                2,000             2,000                *
Gerald A. Eppner                     0                 -                *
ODIN Fondene                   757,700                 -               7.42%
Amvescap PLC                   544,700                 -               5.34%
All directors and executive
  officers as a group (9     1,351,690           432,000              12.70%
  persons)

- ------------
*     Indicates less than one percent.

(1)  Each  person  listed in the table is a director  of the  Company or a named
     executive officer, with an address at c/o OXiGENE,  Inc., One Copley Place,
     Suite 602, Boston, MA 02116, except for ODIN Fondene,  whose address is c/o
     Christiania  Bank og.  Kreditk.  PO Box 1166,  Sentrum Oslo 1, Norway,  and
     Amvescap  PLC,  whose  address is 11  Devonshire  Square,  London  EC2M4YR,
     England.

(2)  Includes  70,588  shares  held by a trust  for the  benefit  of Dr.  Pero's
     children,  and 120,588 shares held by The Ronald Pero Charitable  Remainder
     Unitrust, a trust of which Dr. Pero is the trustee.

(3)  Includes  70 shares held by his  daughter;  157,700  held by a  corporation
     organized under the laws of Sweden of which Dr.  Nordenvall's family is the
     sole stockholder; and 71,300 shares held through a capital insurance placed
     by Dr. Nordenvall.

(4)  Options are held by B.  Omentum AB, a company  organized  under the laws of
     Sweden  of which  Dr.  Nordenvall's  family  is the sole  shareholder.  The
     Company  has a  consulting  agreement  with B.  Omentum  AB.  See  "Certain
     Relationships and Related Transactions.

(5)  Includes 1,320 shares held by Mr.  Soderberg's wife and minor children.

(6)  Options are  held by  Nordberg Capital Inc., a New York  investment banking
     firm, of which Mr. Ionata  is  Director of  Corporate  Finance.  Mr. Ionata
     disclaims beneficial ownership of the option shares.

(7)  Includes  1,000 shares held by his spouse in trust for his children,  as to
     which Professor Caruthers disclaims beneficial ownership.


                                       -18-
<PAGE>


                             EXECUTIVE COMPENSATION

            The following  table sets forth  information for the years indicated
concerning the compensation awarded to, earned by or paid to our named executive
officers  for  services  rendered in all  capacities  to OXiGENE and its Swedish
subsidiary during that period.

SUMMARY COMPENSATION TABLE

                                                                LONG TERM
                                    ANNUAL COMPENSATION        COMPENSATION
                                    -------------------        ------------

                                                               SECURITIES
                                                               UNDERLYING
  NAME AND PRINCIPAL POSITION      YEAR       SALARY($)         OPTIONS(#)

Bjorn Nordenvall                   1998      300,000 (1)        120,053 (2)
   President and Chief             1997      300,000 (1)             --
   Executive Officer               1996      213,710 (1)        165,000 (2)

Ronald W. Pero                     1998      260,366 (3)         46,821 (4)
   Chief Scientific Officer        1997      217,792 (3)         60,000 (4)
                                   1996      233,170 (3)             --

David Sherris                      1998       72,115 (5)         45,000
  Director of Product              1997           --                 --
Development                        1996           --                 --
  and U.S. Operating Officer

Bo Haglund                         1998      119,300             24,253 (7)
   Chief Financial Officer         1997      114,765             30,000 (7)
                                   1996       43,349 (6)             --

Claus M0ller                       1998      200,000 (8)             --
   Chief Medical Officer           1997      185,064 (8)        100,000
                                   1996      146,200 (8)             --

- ------------
(1)  Includes  consulting fees for 1998 of $250,000,  for 1997 of $250,000,  and
     for  1996 of  $163,710.  These  consulting  fees  were  paid to B.  Omentum
     Consulting  AB, a company  organized  under the laws of Sweden of which Dr.
     Nordenvall's family is the sole shareholder. See "Certain Relationships and
     Related Transactions."

(2)   In connection with a repricing  effected in December 1998, 120,053 options
      were granted in exchange for 165,000 options granted in 1996.

(3)   Includes  $114,500 in compensation  that was deferred at the election of
      Dr. Pero.
(4)   In connection with a repricing  effected in December 1998,  46,821 options
      were granted in exchange for 60,000 options granted in 1997.

(5)   Dr.  Sherris  became  Director of Drug  Development in May 1998 and U.S.
      Operating Officer in August 1998.
(6)   Mr. Haglund became Chief Financial Officer of the Company in August 1996.

(7)   In connection with a repricing  effected in December 1998,  24,253 options
      were granted in exchange for 30,000 options granted in 1996.

(8)   Includes consulting fees for 1998 of $80,002, for 1997 of $60,000, and for
      1996 of $145,200,  paid to IPC Nordic A/S, a company  organized  under the
      laws  of  Denmark  of  which  Dr.  M0ller  is  a  director  and  principal
      shareholder.

EMPLOYMENT AND CONSULTING AGREEMENTS

            Employment  Agreement  with Bjorn  Nordenvall.  In October 1995, the
Company entered into an employment agreement with Dr. Nordenvall. The employment
agreement was amended in March 1997, and currently provides for a base salary of
$50,000 per annum.  The  employment  agreement  provides  that either  party may
terminate  the  agreement on one year's prior written  notice.  In addition,  in
October 1995,  the Company  entered into a consulting


                                       -19-
<PAGE>


agreement  with B. Omentum AB, a company  organized  under the laws of Sweden of
which Dr.  Nordenvall's  family is the sole  shareholder,  pursuant to which the
Company  pays  Omentum a  consulting  fee of  $250,000  per year.  See  "Certain
Relationships and Related Transactions."

          Employment  Agreement  with Ronald  Pero.  In April 1997,  the Company
entered into a new employment with Dr. Ronald Pero. The agreement provides for a
base salary of $240,000  per annum.  Pursuant to a prior  deferred  compensation
arrangement,  $114,500  of such base  salary  continues  to be  deferred  at the
election  of  Dr.  Pero.  The  agreement  contains  the  following   termination
provisions:  (1) either party may  terminate  the agreement on six months' prior
written notice, and (2) in the event the Company terminates the employee for any
reason,  other than cause  (which is  defined  as (a) the  continued  failure to
perform  assigned  duties on behalf of OXiGENE,  (b) a material breach of any of
the provisions of the employment  agreement,  and (c) any act of fraud, material
misrepresentation   or   material   omission,   misappropriation,    dishonesty,
embezzlement  or similar  conduct against OXiGENE or the conviction for a felony
or any crime involving moral turpitude),  then the employee is entitled to three
months salary following the effective date of the termination of employment.

          Employment  Agreement  with David  Sherris.  In May 1998,  the Company
entered into an employment agreement with Dr. Sherris, the Company's Director of
Product  Development.  Pursuant to the agreement,  Dr.  Sherris  receives a base
salary of $125,000 per year.  Either party may  terminate the agreement on sixty
days' prior notice.  Subsequently,  in August 1998, Dr. Sherris was appointed to
the additional position of U.S. Operating Officer of the Company.

          Employment  Agreement  with Bo Haglund.  In August  1996,  the Company
entered into an employment  agreement  with Mr.  Haglund,  the  Company's  Chief
Financial Officer. The agreement has a term of three years, ending on August 12,
1999. Pursuant to the agreement,  Mr. Haglund receives a base salary of $110,000
per year.  Either party may terminate the agreement on six months' prior written
notice. In the event the Company terminates Mr. Haglund, Mr. Haglund is entitled
to three months' salary  following the effective date of the  termination of his
employment.

          Consulting  Agreement  with Claus  M0ller.  In May 1998,  the  Company
entered into a new consulting  agreement with Dr. Claus M0ller,  terminating Dr.
M0ller's  prior  employment  and  consulting  arrangements  with the Company and
providing that Dr. M0ller continue to act as a consultant to the Company,  for a
consulting  fee of $200,000 per year.  The  agreement  expires on April 4, 2000,
provided that Dr. M0ller may terminate the Agreement upon 30 days' prior written
notice.

STOCK OPTION GRANTS IN LAST FISCAL YEAR

          The table below provides  information  regarding stock options granted
to each named executive officer, other than Dr. M0ller, during fiscal year 1998.
Dr. Sherris' options were granted to him when he started his employment with the
Company. In December 1998, the Company's  Compensation  Committee authorized the
repricing of certain  options.  All options listed in the table,  other than Dr.
Sherris' options,  represent  repriced options that were granted in


                                      -20-
<PAGE>


exchange for previously granted options. Dr. Sherris elected not to exchange his
options for repriced options.

                         % OF TOTAL
                           AWARDS
                         GRANTED TO  EXERCISE
               OPTIONS   EMPLOYEES   OR BASE               POTENTIAL  REALIZABLE
               GRANTED   IN FISCAL   PRICE     EXPIRATION  VALUE AT    ASSUMED
     NAME        (#)        YEAR      ($/SH)    DATE(1)     ANNUAL      RATES

                                                           5%($)(2)   10%($)(2)
Bjorn          120,053     48.05%      8.9375   06/14/06  1,547,526   2,195,468
Nordenvall
Ronald W. Pero  46,821     18.74%      8.9375   04/04/07    627,534     923,025
David Sherris   45,000     17.09%     12.0000   06/09/08    856,985   1,331,863
Bo Haglund      24,253      9.71%      8.9375   08/12/06    315,070     450,707

(1)  All options in the table,  other than Dr.  Sherris'  options,  are repriced
     options that were granted in exchange for previously  granted options.  The
     repriced options have the same expiration date as the cancelled options.

(2)  The dollar amount under each of these columns assumes that the market price
     of the Company's common stock from the date of the option grant appreciates
     at the cumulative annual rates of 5% and 10%, respectively, over the option
     term of ten years.  The assumed rates of 5% and 10% were established by the
     SEC  and,   therefore,   are  not  intended  to  forecast  possible  future
     appreciation of the Company's common stock.

OPTION EXERCISES AND HOLDINGS AS OF DECEMBER 31, 1998

          No stock  options and other awards were  exercised in fiscal year 1998
by any of the named  executive  officers.  The following table sets forth, as of
December  31,  1998,  the  number  of  unexercised  options  held by each  named
executive  officer and the value  thereof  based on the closing bid price of the
Common Stock of $10.75 on December 31, 1998.

             AGGREGATED OPTION/WARRANT EXERCISES IN LAST FISCAL YEAR
                    AND FISCAL YEAR-END OPTION/WARRANT VALUES

                     NUMBER OF UNEXERCISED       VALUE OF UNEXERCISED IN-THE-
                 OPTIONS/WARRANTS AT FY-END(#)    MONEY OPTIONS/WARRANTS AT
                                                          FY-END($)

      NAME         EXERCISABLE/UNEXERCISABLE      EXERCISABLE/UNEXERCISABLE

Bjorn Nordenvall        165,000/120,053                783,750/217,596
Ronald W. Pero          260,000/46,821                 1,246,250/84,863
David Sherris              0/45,000                          0/0
Bo Haglund                 0/24,253                        0/43,959
Claus M0ller             73,334/50,000                    102,086/0

                CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

          Omentum  Consulting  Agreement.  In October  1995,  we entered into an
consulting  agreement with B. Omentum  Consulting AB, a company  organized under
the laws of Sweden ("Omentum") of which the family of Dr. Bjorn Nordenvall,  our
President and Chief Executive Officer is the sole  shareholder.  Pursuant to the
agreement, we pay Omentum an annual consulting fee of $250,000.


                                       -21-
<PAGE>


                      STOCKHOLDER RETURN PERFORMANCE GRAPH

          The following chart shows cumulative total  shareholder  return on our
common stock,  compared with the Standard & Poor's  Biotechnology Midcap and the
Standard & Poor's Midcap 400 Index.



                                [GRAPH OMITTED]



   MEASUREMENT                        S&P BIOTECHNOLOGY    S&P MIDCAP 400
     PERIOD          OXIGENE, INC.          MIDCAP              INDEX

    12/30/94            71.70              105.57              96.42
    12/30/95            160.38             187.42              126.25
    12/31/96            354.72             165.70              150.49
    12/31/97            264.15             163.19              199.03
    12/31/98            162.26             293.52              237.05


                                       22


<PAGE>

                                OTHER INFORMATION

EXPENSES OF SOLICITATION

          We will bear the costs of soliciting proxies from our stockholders. We
will make this  solicitation by mail, and our directors,  officers and employees
may also solicit proxies by telephone or in person,  for which they will receive
no compensation other than their regular compensation as directors,  officers or
employees.  Arrangements  will  also be made  with  brokerage  houses  and other
custodians,  nominees and  fiduciaries  to send  proxies and proxy  materials to
beneficial owners of the Company's voting securities. The Company will reimburse
these  brokerage  firms,  custodians,  nominees and  fiduciaries  for reasonable
out-of-pocket expenses that are incurred by them.

SHAREHOLDER PROPOSALS

          Your  eligibility  as a stockholder  to submit  proposals,  the proper
subjects of such proposals and other issues governing  stockholder proposals are
regulated by the rules adopted under Section 14 of the  Securities  Exchange Act
of 1934, as amended. If you wish to submit a proposal for inclusion in our proxy
materials  for the 2000 annual  meeting of  stockholders,  we must  receive your
proposal at our  principal  executive  office in the United  States,  One Copley
Place, Suite 602, Boston, Massachusetts 02116, no later than March 1, 2000.

          In  addition,  if you wish to bring a proposal  before the 2000 annual
meeting of  stockholders  but do not wish to have such proposal  included in our
proxy  statement  for that  meeting,  you must  give us  written  notice of your
proposal at the address set forth in the preceding  paragraph,  on or before May
14,  2000 in order  for your  proposal  to be  considered  timely.  The  persons
designated as our proxies in connection  with the 2000 annual  meeting will have
discretionary voting authority with respect to any stockholder proposal of which
we do not receive timely notice.

          Each proposal  submitted  should include the full and correct name and
address  of the  stockholder(s)  making  the  proposal,  the  number  of  shares
beneficially  owned and their date of  acquisition.  If beneficial  ownership is
claimed,  proof  thereof  should  also  be  submitted  with  the  proposal.  The
stockholder  or his or her  representative  must  appear in person at the annual
meeting and must present the proposal, unless he or she can show good reason for
not doing so.

ANNUAL REPORT

          A copy of our Annual Report to  Stockholders is being provided to each
of our stockholder with this Proxy Statement.  Additional copies may be obtained
by writing to OXiGENE, Inc., One Copley Place, Suite 602, Boston,  Massachusetts
02116, Attention: Corporate Secretary.

                                    By Order of the Board of Directors


Dated: May 25, 1999                 Bo Haglund, Corporate Secretary


                                       -23-



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