OXIGENE INC
10-K/A, 1999-04-30
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                                  FORM 10-K/A-1

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

- --------------------------------------------------------------------------------

                                Amendment No. 1
                                       to
                  Annual Report Pursuant to Section 13 or 15(d)
                     of the Securities Exchange Act of 1934

                   For the fiscal year ended December 31, 1998
                           Commission File No. 0-21990


                                  OXiGENE, INC.
             ------------------------------------------------------
             (Exact name of registrant as specified in its charter)


- --------------------------------------------------------------------------------


           Delaware                                      13-3679168
- -------------------------------             ------------------------------------
(State or other jurisdiction of             (IRS employer identification number)
incorporation or organization)


                  One Copley Place, Suite 602, Boston, MA 02116
                  ---------------------------------------------
                    (Address of principal executive offices)

                                 (617) 536-9500
                     ---------------------------------------
                     (Telephone number, including area code)


Securities registered pursuant to Section 12(b) of the Act:  None

Securities registered pursuant to Section 12(g) of the Act:


                     Common Stock, par value $.01 per share
                  Warrant to purchase one share of Common Stock
                  ---------------------------------------------
                               Title of Each Class


     Indicate  by check mark  whether the  registrant  (1) has filed all reports
required to be filed by Section 13 or 15(d) of the  Securities  Exchange  Act of
1934  during  the  preceding  12 months  (or for such  shorter  period  that the
registrant was required to file such reports),  and (2) has been subject to such
filing requirements for the past 90 days. Yes X No

     Indicate by check mark if disclosure of delinquent  filers pursuant to Item
405 of Regulation S-K is not contained herein, and will not be contained, to the
best of registrant's  knowledge,  in definitive proxy or information  statements
incorporated by reference in Part III of this Form 10-K or any amendment to this
Form 10-K. [ ]

     The  approximate  aggregate  market  value  of the  voting  stock  held  by
non-affiliates of the registrant as of March 19, 1999 was $83,573,736,  based on
the closing price of $8.875 on that date.

     As of March 19, 1999, the aggregate number of outstanding  shares of Common
Stock of the registrant was 10,207,049.

<PAGE>

                                TABLE OF CONTENTS

SAFE HARBOR FOR FORWARD-LOOKING STATEMENTS UNDER THE SECURITIES
     LITIGATION REFORM ACT OF 1995

PART I - Previously filed

PART II - Previously filed

PART III
     10.  DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT
     11.  EXECUTIVE COMPENSATION
     12.  SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND
          MANAGEMENT
     13.  CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

PART IV - Previously filed

SIGNATURES


                                  Defined Terms

"OXiGENE," "we," "us," "our" or "Company" means collectively  OXiGENE,  Inc. and
its subsidiary OXiGENE Europe AB.

"Plan" or "stock incentive plan" means the OXiGENE 1996 Stock Incentive Plan.

"named executive officer" means collectively Bjorn Nordenvall, our President and
Chief Executive  Officer,  the three next highest paid executive officers at the
end of 1998 named in the "Summary Compensation Table" and Claus Moller, a former
executive who ceased to be our employee on April 30, 1998.


SAFE HARBOR FOR FORWARD-LOOKING STATEMENTS UNDER
THE SECURITIES LITIGATION REFORM ACT OF 1995

     Except for historical  information  contained herein, this Amendment to our
Annual Report on Form 10-K ("Annual Report") contains forward-looking statements
within the  meaning of the  Private  Securities  Litigation  Reform Act of 1995.
These  statements  involve  known and unknown risks and  uncertainties  that may
cause the Company's  actual results or outcomes to be materially  different from
those  anticipated and discussed  herein.  Further,  the Company  operates in an
industry sector where securities values may be volatile and may be influenced by
regulatory and other factors  beyond the Company's  control.  Important  factors
that the Company  believes may cause such differences are discussed in the "Risk
Factors"  section  of  our  Annual  Report  and  in  the  cautionary  statements
accompanying the  forward-looking  statements in our Annual Report. In assessing
forward-looking statements contained herein, readers are urged to read carefully
all Risk Factors and cautionary statements contained in our Annual Report.

<PAGE>

                                    PART III

10.  DIRECTORS AND EXECUTIVE OFFICERS OF THE REGISTRANT.


                                    Directors

     The age (as of March 31, 1999),  business experience,  principal occupation
and  employment  of our  incumbent  directors,  each of whom  is a  nominee  for
election at our 1999 Annual Meeting of Stockholders,  which has been rescheduled
to be held on June 29, 1999, is as follows:


Marvin H. Caruthers, Ph.D.

Age:                      59

Director Since:           1996

Principal Occupation:     Professor  of  Chemistry  and   Biochemistry   at  the
                          University of Colorado, Boulder, Colorado.

Business Experience:      Scientific  co-founder  of, and a consultant to, Amgen
                          Inc.,   a   biotechnology   company   engaged  in  the
                          development  of products  derived from gene  synthesis
                          capabilities.   Scientific   co-founder   of   Applied
                          Biosystems  Inc., a  biotechnology  company engaged in
                          the  development  of  DNA   synthesizers  and  protein
                          sequencers   and  a  division   of  The   Perkin-Elmer
                          Corporation.

Other Directorships:      BioStar, Inc., a biotechnology company.  Skandigen AB,
                          a publicly-traded Swedish biotechnology company.


Gerald A. Eppner

Age:                      60

Director Since:           1997

Principal Occupation:     Partner, Cadwalader, Wickersham & Taft, a New York law
                          firm that is outside counsel to the Company.

Business Experience:      Domestic and  international  corporate and  securities
                          law matters. Prior to January 1998, partner in the New
                          York City law firm of Battle Fowler LLP.

Other Directorships:      None.


Michael Ionata

Age:                      47

Director Since:           1995

Principal Occupation:     Director  of  Corporate  Finance of  Nordberg  Capital
                          Inc., an investment banking firm based in New York.

Business Experience:      Corporate  finance and venture  capital  management at
                          Den Norske  Bank, a Norwegian  bank,  from May 1983 to
                          May 1991.  Specializing  in  valuations,  cost-benefit
                          analysis and  restructurings  at Coopers & Lybrand LLP
                          prior to May 1991.

Other Directorships:      C.E.L. Industries Poland, a restaurant company.

<PAGE>

Arthur B. Laffer

Age:                      58

Director Since:           1998

Principal Occupation:     Chairman  and  chief   executive   officer  of  Laffer
                          Associates,   an  economic   research  and   financial
                          consulting firm.

Business Experience:      Co-founder  and chairman of Calport Asset  Management,
                          an  institutional  money  management  firm.  Member of
                          President Reagan's Economic Policy Advisory Board from
                          1980 to 1988.  Member of the Policy  Committee and the
                          board of directors of the American Council for Capital
                          Formation in Washington, D.C. Distinguished University
                          Professor at  Pepperdine  University,  and a member of
                          Pepperdine's  board of directors.  Charles B. Thornton
                          Professor of Business  Economics at the  University of
                          Southern  California  from  1976  to  1984.  Associate
                          Professor of Business  Economics at the  University of
                          Chicago   from  1970  to  1976.   Consultant   to  the
                          Secretaries  of Treasury and Defense  during the years
                          1972-1977.  First  chief  economist  at the  Office of
                          Management   and  Budget  under  George  Schultz  from
                          October 1970  through  July 1972,  on leave of absence
                          from the University of Chicago.

Other Directorships:      Nicholas-Applegate  Mutual  Funds;  Nicholas-Applegate
                          Growth Equity Fund;  United States Filter Corp., a New
                          York Stock  Exchange-listed  manufacturer and operator
                          of sewage and water treatment facilities, MasTec Inc.,
                          a New York Stock Exchange-listed  company specializing
                          in  telecommunications  infrastructure,  and  Coinmach
                          Corp. a Nasdaq National  Market-listed company engaged
                          in coin-operated laundry equipment.


Bjorn Nordenvall, M.D., Ph.D.

Age:                      47

Director Since:           1995

Principal Occupation:     OXiGENE's  President and Chief  Executive  Officer and
                          Chairman of the Board of Directors.

Business Experience:      General  surgeon.  President  of  Sophiahemmet  AB,  a
                          Stockholm-based hospital, from 1987 to September 1996.
                          President  of Carnegie  Medicine  AB, a  biotechnology
                          company,  during 1983 and 1984.  Practiced  surgery at
                          Danderyd Hospital,  Stockholm, from 1977 through 1985.
                          Consultant to Carnegie,  a Swedish  investment banking
                          company, from 1984 through 1986. Consultant to Skandia
                          Insurance Company, a Swedish insurance company,  since
                          1984.

Other Directorships:      None.

<PAGE>

Ronald W. Pero, Ph.D.

Age:                      58

Director Since:           1988

Principal Occupation:     OXiGENE's Chief Scientific Officer.

Business Experience:      Research with specialty in the field of DNA repair and
                          its relation to cancer treatment.  Associate  research
                          professor  (1989-1994)  and adjunct  professor  (since
                          1994)  at  New   York   University   Medical   Center,
                          Department  of  Environmental  Medicine.  Professor of
                          Molecular  Ecogenetics  at the  University  of Lund in
                          Lund, Sweden. Research Professor of Medicine at Boston
                          University  School of Medicine since  September  1997.
                          Member of the  American  Association  of Science,  New
                          York  Academy of  Sciences,  International  Preventive
                          Oncology  Society,  European  Society for  Therapeutic
                          Radiation  Oncology  and The American  Association  of
                          Cancer  Research,  as well as  serving  as  Scientific
                          Director  of the  Board  of  Trustees  of the  Swedish
                          American Research Foundation.

Other Directorships:      None.


Per-Olof Soderberg

Age:                      44

Director Since:           1997

Principal Occupation and  Chief executive  officer of Dahl  International  AB, a
Business Experience:      publicly-traded,   wholesale  sanitation  and  heating
                          products company in Stockholm, Sweden, and Copenhagen,
                          Denmark.

Other Directorships:      Bergman & Beving AB, a publicly-traded trading company
                          in  Scandinavia.  Martin  Olsson,  a food  whole-saler
                          based in Sweden.  Skandia  Investment  Management,  an
                          insurance investment company.

<PAGE>

                           Board of Directors Meetings

     During 1998,  the Board of Directors  held seven  meetings.  Except for Dr.
Caruthers,  attendance  by  incumbent  Directors  at  meetings  of the  Board of
Directors and its Committees was at least 75%.


                                   Committees

     The  Board  of  Directors  has   established  the  following  two  standing
committees to assist it in meeting its responsibilities:

Audit Committee

Members:                        Gerald A. Eppner (Chairman)
                                Arthur B. Laffer

Number of Meetings in 1998:     None.

Functions:                      Reviews the scope and timing of the  independent
                                auditors'   audit   and  other   services,   the
                                auditors'  report  on  the  Company's  financial
                                statements  following  completion of their audit
                                and the Company's  policies and procedures  with
                                respect to  internal  accounting  and  financial
                                controls.

                                Makes  annual  recommendations  to the  Board of
                                Directors    regarding   the    appointment   of
                                independent auditors for the ensuing year.


Compensation Committee

Members:                        Michael Ionata (Chairman)
                                Per-Olof Soderberg

Number of Meetings in 1998:     6

Functions:                      Makes  recommendations to the Board of Directors
                                with respect to:

                                (1)  compensation  philosophy and guidelines for
                                     executives;

                                (2)  the roles and performances of the Company's
                                     executive  officers,  especially  as  these
                                     affect compensation;

                                (3)  appropriate  compensation  levels  for  the
                                     Chief    Executive    Officer   and   other
                                     executives,  based on a comparative  review
                                     of  compensation   practices  in  similarly
                                     situated business; and

                                (4)  the  design  and   implementation   of  our
                                     compensation plans and the establishment of
                                     criteria  and the  approval of  performance
                                     results relative to our incentive plans.

<PAGE>

                            Compensation of Directors


Fees

     Directors  receive  no  cash  compensation  for  serving  on the  Board  of
Directors,   other  than  reimbursement  of  reasonable   expenses  incurred  in
connection with meetings actually attended.

Stock Plan

     Under the terms of the 1998 Stock Incentive  Plan,  Directors also receive,
upon first  being  elected to the Board of  Directors,  options to  purchase  an
aggregate of 55,000 shares. The options vest in five equal,  annual,  cumulative
installments of 11,000 shares.


                        Executive Officers of the Company

     See section captioned "Directors" above for information  pertaining to Drs.
Nordenvall and Pero,  the Company's  executive  officers  holding the offices of
Chief  Executive   Officer  and  President,   and  Chief   Scientific   Officer,
respectively.  In addition to the foregoing executive officers, Dr. David Sherry
serves as our Director of Drug Development and U.S. Operating  Officer,  and Mr.
Haglund serves as our Chief Financial Officer.

     David  Sherris,  Ph.D.,  46, joined  OXiGENE in May 1998 as the Director of
Drug  Development  and, in June 1998,  assumed the  additional  position of U.S.
Operating  Officer.  Dr.  Sherris'   responsibilities   include  overseeing  the
development of OXiGENE's  products and overall  operations in the United States.
Dr. Sherris has over 16 years of experience in academics and industry.  Prior to
joining  OXiGENE,  Dr.  Sherris was in charge of managing the external  research
program  for the  Department  of  Experimental  Therapeutics  at  Ares  Advanced
Technology,  a division  of the  Ares-Serono  Group,  a  pharmaceutical  company
engaged  in  cancer  and  fertility  therapeutics.  Dr.  Sherris  has also  held
managerial and research positions at Unilever  Research,  a division of Unilever
N.V., a global  chemical  and  pharmaceutical  concern,  and  Centocor,  Inc., a
biotechnology  company  engaged  in  a  multitude  of  therapeutic   indications
including cardiovascular, oncologic and arthritic diseases, as well as a faculty
position in the Division of Clinical  Immunology,  Department  of Medicine,  Mt.
Sinai Medical Center, New York, New York.

     Bo Haglund,  47, was appointed Chief Financial Officer in August 1996. From
January  1992 to August  1996,  Mr.  Haglund  was  employed  by D.  Carnegie  AB
("Carnegie") in various capacities, most recently heading its London operations,
focusing on the  marketing  of Nordic  securities  to U.K.  investors.  Prior to
joining Carnegie,  from November 1990 to January 1992, Mr. Haglund was executive
vice president and chief financial officer of Swedish Exploration Consortium AB,
a Swedish  publicly-traded  company  engaged  in oil and gas  exploration.  From
January 1988 to October 1990,  Mr.  Haglund was vice  president  finance of Cool
Carriers AB, a shipping  company,  and from April 1982 to December  1987, he was
chief financial officer of Gulf Agency Group, a ship brokerage company.


Employment and Consulting Agreements

     Employment  Agreement with Bjorn  Nordenvall.  In October 1995, the Company
entered  into an  employment  agreement  with  Dr.  Nordenvall.  The  employment
agreement was amended in March 1997, and currently provides for a base salary of
$50,000 per annum.  The  employment  agreement  provides  that either  party may
terminate  the  agreement on one year's prior written  notice.  In addition,  in
October 1995,  the Company  entered into a consulting  agreement with B. Omentum
AB, a company  organized under the laws of Sweden of which Dr. Nordenvall is the
sole shareholder, pursuant to which the Company pays Omentum a consulting fee of
$250,000 per year. See "Certain Relationships and Related Transactions."

     Employment  Agreement with Ronald Pero. In April 1997, the Company  entered
into a new employment  with Dr. Ronald Pero.  The agreement  provides for a base
salary  of  $240,000  per  annum.  Pursuant  to a  prior  deferred  compensation
arrangement,  $114,500  of such base  salary  continues  to be  deferred  at the
election  of  Dr.  Pero.  The  agreement  contains  the  following   termination
provisions:  (1) either party may  terminate  the agreement on six months' prior
written notice, and (2) in the event the Company terminates the employee for any
reason,  other than cause  (which is  defined  as (a) the  continued  failure to
perform  assigned  duties on behalf of OXiGENE,  (b) a material breach of any of
the provisions of the employment  agreement,  and (c) any act of fraud, material
misrepresentation   or   material   omission,   misappropriation,    dishonesty,
embezzlement  or similar  conduct against OXiGENE or the conviction for a felony
or any crime involving moral turpitude),  then the employee is entitled to three
months salary following the effective date of the termination of employment.

     Employment  Agreement with David Sherris.  In May 1998, the Company entered
into an employment agreement with Dr. Sherris, the Company's Director of Product
Development.  Pursuant to the agreement,  Dr. Sherris  receives a base salary of
$125,000 per year. Either party may terminate the agreement on sixty days' prior
notice.  Subsequently,  in  August  1998,  Dr.  Sherris  was  appointed  to  the
additional position of U.S. Operating Officer of the Company.

     Employment  Agreement with Bo Haglund.  In August 1996, the Company entered
into an employment  agreement with Mr.  Haglund,  the Company's  Chief Financial
Officer.  The  agreement  has a term of three years,  ending on August 12, 1999.
Pursuant  to the  agreement,  Mr.  Haglund  currently  receives a base salary of
approximately $110,000 per year. Either party may terminate the agreement on six
months' prior written notice.  In the event the Company  terminates Mr. Haglund,
Mr. Haglund is entitled to three months' salary  following the effective date of
the termination of his employment.

     Consulting  Agreement with Claus Moller.  In May 1998, the Company  entered
into a new consulting agreement with Dr. Claus Moller,  terminating Dr. Moller's
prior employment and consulting arrangements with the Company and providing that
Dr. Moller continue to act as a consultant to the Company,  for a consulting fee
of $200,000 per year.  The  agreement  expires on April 4, 2000,  provided  that
Dr. Moller may terminate the Agreement upon 30 days' prior written notice.


                  Section 16(a) Beneficial Ownership Reporting

     Section 16(a) of the Securities Exchange Act of 1934 requires our Directors
and executive  officers,  and persons who own more than 10% of our common stock,
to file with the  Securities  and Exchange  Commission  (the "SEC"),  the Nasdaq
National Market and the Company reports of ownership and changes in ownership of
common  stock and other  equity  securities  of the  Company.  Based solely on a
review of the reports and representations provided to us by the above-referenced
persons, we believe that during 1998 all filing  requirements  applicable to our
reporting  officers,  directors and greater than ten percent  beneficial  owners
were properly and timely satisfied,  except that Mr. Laffer and Dr. Sherris each
filed late a Form 3 (Initial Statement of Beneficial Ownership). In making these
statements,  we have relied on  representations  of our directors,  officers and
greater  than ten percent  beneficial  owners,  and copies of reports  they have
filed with the SEC.

<PAGE>

11.  EXECUTIVE COMPENSATION.

                             Executive Compensation

     The  following  table  sets  forth  information  for  the  years  indicated
concerning the compensation awarded to, earned by or paid to our named executive
officers  for  services  rendered in all  capacities  to OXiGENE and its Swedish
subsidiary during that period.


<TABLE>
                                 Summary Compensation Table

<CAPTION>
                                         Annual Compensation     Long Term Compensation
                                         -------------------     ----------------------
                                                                      Securities
Name and Principal Position              Year     Salary($)      Underlying Options(#)
- ---------------------------              ----     ---------      ---------------------
<S>                                      <C>      <C>            <C>

Bjorn Nordenvall                         1998     300,000(1)           120,053(2)
   President and                         1997     300,000(1)                --
   Chief Executive Officer               1996     213,710(1)           165,000(2)

Ronald W. Pero                           1998     260,366(3)            46,821(4)
   Chief Scientific Officer              1997     217,792(3)            60,000(4)
                                         1996     233,170(3)                --

David Sherris                            1998      72,115(5)            45,000
 Director of Product Development and     1997          --                   --
 U.S. Operating Officer                  1996          --                   --

Bo Haglund                               1998     119,300               24,253(7)
   Chief Financial Officer               1997     114,765                   --
                                         1996      43,349(6)            30,000(7)

Claus Moller                             1998     200,000(8)                --
   Chief Medical Officer                 1997     185,064(8)           100,000
                                         1996     146,200(8)                --

<FN>
- ---------------
(1)  Includes consulting fees for 1998 of $250,000,  for 1997 of $250,000, and for 1996
     of  $163,710.  These  consulting  fees were paid to B.  Omentum  Consulting  AB, a
     company  organized  under the laws of Sweden of which Dr.  Nordenvall  is the sole
     shareholder. See "Certain Relationships and Related Transactions."
(2)  In connection  with a repricing  effected in December 1998,  120,053  options were
     granted in exchange for 165,000 options granted in 1996.
(3)  Includes $114,500 in compensation that was deferred at the election of Dr. Pero.
(4)  In connection  with a repricing  effected in December  1998,  46,821  options were
     granted in exchange for 60,000 options granted in 1997.
(5)  Dr. Sherris  became  Director of Drug  Development in May 1998 and U.S.  Operating
     Officer in August 1998.
(6)  Mr. Haglund became Chief Financial Officer of the Company in August 1996.
(7)  In connection  with a repricing  effected in December  1998,  24,253  options were
     granted in exchange for 30,000 options granted in 1996.
(8)  Includes consulting fees for 1998 of $80,002, for 1997 of $60,000, and for 1996 of
     $145,200, paid to IPC Nordic A/S, a company organized under the laws of Denmark of
     which Dr. Moller is a director and principal shareholder.
</FN>
</TABLE>

<PAGE>

                     Stock Option Grants in Last Fiscal Year

     The table below provides  information  regarding  stock options  granted to
each named executive  officer,  other than Dr. Moller,  during fiscal year 1998.
Dr. Sherris' options were granted to him when he started his employment with the
Company. In December 1998, the Company's  Compensation  Committee authorized the
Company to offer to reprice  certain  options by exchanging  previously  granted
options for repriced  options.  With respect to all persons listed in the table,
other  than Dr.  Sherris',  we have  assumed  that they will elect to accept the
repricing  offer.  Dr.  Sherris  has  elected  not to  exchange  his options for
repriced options.


<TABLE>
<CAPTION>
                                                                                 Potential Realizable Value at
                                                                                     Assumed Annual Rates
                                                                                 -----------------------------
                                     % of
                                 Total Awards
                     Options      Granted to      Exercise or
                     Granted     Employees in     Base Price      Expiration
      Name             (#)       Fiscal Year        ($/Sh)         Date(1)          5%($)(2)      10%($)(2)
      ----           -------     ------------     -----------     ----------        --------      ---------
<S>                  <C>         <C>              <C>             <C>               <C>           <C>

Bjorn Nordenvall     120,053        48.62%           8.9375       06/14/06          1,547,526     2,195,468

Ronald W. Pero        46,821        18.57%           8.9375       04/04/07            627,534       923,025

David Sherris         45,000        17.85%          12.0000       06/09/08            856,985     1,331,863

Bo Haglund            24,253         9.62%           8.9375       08/12/06            315,070       450,707

<FN>
- ---------------
(1)  All options in the table,  other than Dr.  Sherris'  options,  are repriced  options that were granted in
     exchange for previously  granted  options.  The original  options had a term of ten years,  which was not
     changed in connection with the repricing.
(2)  The dollar amount under each of these columns assumes that the market price of the Company's common stock
     from the date of the option grant appreciates at the cumulative annual rates of 5% and 10%, respectively,
     over the option  term of ten years.  The  assumed  rates of 5% and 10% were  established  by the SEC and,
     therefore, are not intended to forecast possible future appreciation of the Company's common stock.
</FN>
</TABLE>


              Option Exercises and Holdings as of December 31, 1998

     No stock options and other awards were exercised in fiscal year 1998 by any
of the named executive officers.  The following table sets forth, as of December
31, 1998, the number of unexercised options held by each named executive officer
and the value  thereof  based on the  closing  bid price of the Common  Stock of
$10.75 on December 31, 1998.


             Aggregated Option/Warrant Exercises in Last Fiscal Year
                    and Fiscal Year-End Option/Warrant Values

                                                         Value of Unexercised
                    Number of Unexercised Options/      In-the-Money Options/
                        Warrants at FY-End(#)           Warrants at FY-End($)
                    ------------------------------    -------------------------
      Name            Exercisable/Unexercisable       Exercisable/Unexercisable
      ----          ------------------------------    -------------------------

Bjorn Nordenvall          165,000/120,053                 783,750/217,596

Ronald W. Pero            260,000/46,821                1,246,250/84,863

David Sherris                   0/45,000                        0/0

Bo Haglund                      0/24,253                        0/43,959

Claus Moller               73,334/50,000                  102,086/0

<PAGE>

12.  SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT.

     The table  below shows how many shares of common  stock each  Director  and
each named executive officer and the Directors and executive officers as a group
beneficially  owned as of April 9, 1999.  Except as otherwise noted, each person
listed in the table owns all shares  directly and has sole voting and investment
power.


<TABLE>
<CAPTION>
                                                          Shares subject to options
             Name(1)                    No. of Shares         included in total         % of Total
             -------                    -------------     -------------------------     ----------
<S>                                     <C>               <C>                           <C>

Ronald W. Pero                           690,000(2)              260,000                   6.59%
Bjorn Nordenvall                         402,570(3)              165,000(4)                3.88%
Per-Olof Soderberg                       120,220(5)                    -                   1.17%
Claus Moller                             129,400                  73,334                   1.26%
David Sherris                              1,000                       -                    *
Bo Haglund                                     0                       -                    *
Michael Ionata                             5,000                   5,000(6)                 *
Marvin H. Caruthers                        1,500(7)                    -                    *
Arthur B. Laffer                           2,000                   2,000                    *
Gerald A. Eppner                               0                       -                    *
Amvescap PLC                             544,700                       -                   5.34%
All directors and executive            1,351,690                 432,000                  12.70%
  officers as a group (9 persons)

<FN>
- ---------------

*    Indicates less than one percent.

(1)  Each person  listed in the table is a director of the Company or a named  executive  officer,
     with an address at c/o OXiGENE,  Inc., One Copley Place, Suite 602, Boston, MA 02116,  except
     for Amvescap PLC, whose address is 11 Devonshire Square, London EC2M4 and Amvescap PLC, whose
     address is 11 Devonshire Square, London EC2M4YR, England.

(2)  Includes  70,588 shares held by a trust for the benefit of Dr. Pero's  children,  and 120,588
     shares held by The Ronald Pero Charitable  Remainder  Unitrust,  a trust of which Dr. Pero is
     the trustee.

(3)  Includes 70 shares held by his daughter;  157,700 held by a corporation  organized  under the
     laws of Sweden of which Dr.  Nordenvall  is the sole  stockholder;  and  71,300  shares  held
     through a capital insurance placed by Dr. Nordenvall.

(4)  Options are held by B. Omentum AB, a company  organized under the laws of Sweden of which Dr.
     Nordenvall is the sole  shareholder.  The Company has a consulting  agreement with B. Omentum
     AB. See Item 13 "Certain Relationships and Related Transactions.

(5)  Includes 1,320 shares held by Mr. Soderberg's wife and minor children.

(6)  Options are held by Nordberg  Capital Inc., a New York investment  banking firm, of which Mr.
     Ionata is Director of Corporate  Finance.  Mr. Ionata disclaims  beneficial  ownership of the
     option shares.

(7)  Includes  1,000 shares held by his spouse in trust for his  children,  as to which  Professor
     Caruthers disclaims beneficial ownership.

</FN>
</TABLE>

<PAGE>

13.  CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS.

     Omentum Consulting  Agreement.  In October 1995, the Company entered into a
consulting  agreement with B. Omentum  Consulting AB, a company  organized under
the laws of Sweden ("Omentum") of which Dr. Bjorn Nordenvall, a director and the
President and Chief Executive  Officer of the Company,  is the sole shareholder.
Pursuant to the agreement,  the Company pays Omentum an annual consulting fee of
$250,000.

<PAGE>

                                   SIGNATURES

     Pursuant  to the  requirements  of  Section  13 or 15(d) of the  Securities
Exchange Act of 1934,  the  Registrant has duly caused this amended report to be
signed on its behalf by the undersigned, thereunto duly authorized.

                                      OXiGENE, INC.


                                      By:  /s/ Bjorn Nordenvall
                                           ------------------------------------
                                           Bjorn Nordenvall
                                           President and Chief Executive Officer
                                           April 29, 1999


     Pursuant to the  requirements of the Securities  Exchange Act of 1934, this
report has been signed by the following  persons on behalf of the registrant and
in the capacities and on the dates indicated.

       Signature                          Title                        Date
       ---------                          -----                        ----

/s/ Bjorn Nordenvall        President, Chief Executive Officer    April 29, 1999
- ------------------------    and Director
                            (principal executive officer)

Bjorn Nordenvall

/s/ Bo Haglund                    Chief Financial Officer         April 29, 1999
- ------------------------
Bo Haglund


/s/ Marvin H. Caruthers                  Director                 April 29, 1999
- ------------------------
Marvin H. Caruthers


/s/ Michael Ionata                       Director                 April 29, 1999
- ------------------------
Michael Ionata


/s/ Arthur B. Laffer                     Director                 April 29, 1999
- ------------------------
Arthur B. Laffer


/s/ Ronald W. Pero               Chief Scientific Officer         April 29, 1999
- ------------------------              and a Director
Ronald W. Pero


/s/ Per-Olof Soderberg                   Director                 April 29, 1999
- ------------------------
Per-Olof Soderberg


/s/ Gerald A. Eppner                     Director                 April 29, 1999
- ------------------------
Gerald A. Eppner



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