GLYKO BIOMEDICAL LTD
DEFS14A, 1999-02-10
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
Previous: BORG WARNER AUTOMOTIVE INC, 8-K/A, 1999-02-10
Next: LEVEL ONE COMMUNICATIONS INC /CA/, 424B1, 1999-02-10



                              GLYKO BIOMEDICAL LTD.
                            Scotia Plaza, Suite 2100
                               40 King Street West
                                Toronto, Ontario
                                     M5H 3C2

                    NOTICE OF SPECIAL MEETING OF SHAREHOLDERS

TAKE NOTICE THAT a Special Meeting of Shareholders of GLYKO BIOMEDICAL LTD. will
be held at Suite 2100, Scotia Plaza, 40 King Street West, Toronto,  Ontario, M5H
3C2 on the 10th day of March,  1999 at the hour of 8:30  o'clock in the  morning
(Local Time), for the following purposes:

1.       To consider and if deemed advisable pass, with or without variation,  a
         resolution  authorizing the grant of options to purchase 100,000 common
         shares of the  Corporation  at a price of  US$0.50  per share  expiring
         October 25, 2001; and

2.       To consider and if deemed advisable pass, with or without variation,  a
         resolution  authorizing the re-pricing of options previously granted on
         December 10, 1992 to certain insiders of the Corporation to purchase up
         to 300,000  common shares from an exercise price of Cdn.$2.75 per share
         to an exercise  price of Cdn.$1.00 per share and ratifying the exercise
         of 300,000 of such options;

3.       To transact such other  business as properly may be brought  before the
         Special Meeting or any adjournment or adjournments thereof.

Shareholders  who are  unable to  attend  the  Special  Meeting  in  person  are
requested  to sign and return to the  Corporation  the  enclosed  form of proxy.
Executed  forms of proxy must be deposited with Montreal Trust Company of Canada
not less than 48 hours  excluding  Saturdays and holidays,  prior to the Special
Meeting or any adjournment or  adjournments  thereof or with the Chairman of the
Special Meeting prior to commencement thereof.

The Board of  Directors  has fixed the close of  business on February 2, 1999 as
the record date for the determination of Shareholders  entitled to the Notice of
Special Meeting and any adjournment or adjournments thereof.

DATED this 28th day of January, 1999.

By order of the Board

/s/John C. Klock
John C. Klock, M.D.
President and
Chief Executive Officer









                              GLYKO BIOMEDICAL LTD.






                         Management Information Circular
























                                January 28, 1999


<PAGE>






                              GLYKO BIOMEDICAL LTD.
                            Scotia Plaza, Suite 2100
                               40 King Street West
                                Toronto, Ontario
                                     M5H 3C2


                         MANAGEMENT INFORMATION CIRCULAR


SOLICITATION OF PROXIES

This  Management  Information  Circular  is  furnished  in  connection  with the
solicitation  of  proxies  by the  Management  of  Glyko  Biomedical  Ltd.  (the
"Corporation") for use at the Special Meeting of Shareholders of the Corporation
(the  "Meeting") to be held at the time and place and for the purposes set forth
in the attached  Notice of Special  Meeting of  Shareholders.  It is anticipated
that  the  solicitation  will be by mail  primarily,  but  proxies  may  also be
solicited  personally by regular employees of the Corporation.  The cost of such
solicitation will be borne by the Corporation.

The form of proxy  forwarded to Shareholders on February 4, 1999 with the Notice
of Special Meeting confers discretionary  authority upon the proxy nominees with
respect  to various  matters  identified  in the  Notice of  Special  Meeting of
Shareholders or other matters which may properly come before the Meeting.

The form of proxy affords the  Shareholder  the  opportunity to specify that the
shares  registered  in his name shall be voted or withheld from voting on and to
vote for or against any ballot that may be called  for, in  accordance  with the
specifications made by Shareholders.

In  respect of proxies in which the  Shareholders  have not  specified  that the
proxy nominees are required to vote for or vote against,  the shares represented
by such proxies will be voted for the applicable resolutions.


APPOINTMENT AND REVOCATION OF PROXIES

A Shareholder  has the right to appoint a person (who need not be a Shareholder)
to  attend  and act for him and on his  behalf  at the  Meeting  other  than the
persons designated in the enclosed form of proxy. Such right may be exercised by
striking out the names of the persons  designated  in the enclosed form of proxy
and by  inserting  in the blank space  provided for that purpose the name of the
desired  person or by  completing  another  proper  form of proxy and, in either
case,  delivering the completed and executed  proxy to the registered  office of
the  Corporation  or the  Corporation's  transfer  agent  not less than 48 hours
(exclusive of Saturdays and holidays) before the time of the Meeting or with the
Chairman  of the  Meeting  before  the time of the  Meeting  or any  adjournment
thereof.

<PAGE>



                                      -2-

A  Shareholder  who has given a proxy may  revoke it at any time in so far as it
has not been exercised. A proxy may be revoked, as to any matter on which a vote
shall not already  have been cast  pursuant to the  authority  conferred by such
proxy,  by instrument in writing  executed by the Shareholder or by his attorney
authorized  in writing or, if the  Shareholder  is a body  corporate,  under its
corporate  seal or by an  officer  or  attorney  thereof  duly  authorized,  and
deposited  either at the registered  office of the Corporation at any time up to
and including  the last  business day  preceding the day of the Meeting,  or any
adjournment  thereof,  at which the proxy is to be used or with the  Chairman of
such  Meeting on the day of the  Meeting or any  adjournment  thereof,  and upon
either of such deposits the proxy is revoked. A proxy may also be revoked in any
other manner permitted by law.


VOTING SECURITIES AND PRINCIPAL HOLDERS THEREOF

On  January  28,  1999,  28,950,029  Common  Shares  without  par  value  of the
Corporation were issued and  outstanding.  Each Common Share entitles the holder
thereof to one vote at all meetings of Shareholders.

All  holders  of Common  Shares of record as of the time of the  Meeting  or any
adjournment thereof are entitled either to attend and vote thereat in person the
Common  Shares held by them or,  provided a completed  and executed  proxy shall
have been delivered to the Corporation,  to attend and vote thereat by proxy the
Common Shares held by them.

The following table lists certain information  regarding beneficial ownership of
the Corporation's Common Shares as of January 28, 1999, by (i) those persons who
own  more  than  5%  of  the  Corporation's  common  stock,  (ii)  each  of  the
Corporation's  "Named Executive Officers" (as defined below),  (iii) each of the
Corporation's directors, and (iv) by the Corporation's officers and directors as
a group. The statements as to the shares of the Corporation  beneficially  owned
or over which control or direction is exercised by the  Corporation's  directors
are in each instance based upon information furnished by the person concerned.



<PAGE>


                                      -3-
<TABLE>

- ------------------------------ ---------------------------------- ---------------------- =======================

<CAPTION>
                                Name and Address of Beneficial    Number of Shares Held     Percent of Class
       Title of Class                        Owner
- ------------------------------ ---------------------------------- ---------------------- =======================
- ------------------------------ ---------------------------------- ---------------------- =======================
<S>                            <C>                                <C>                    <C>
Common Shares                  New York Life Insurance Company             4,185,000(1)          13.8%
                               51 Madison Avenue
                               New York, NY 10010

- ------------------------------ ---------------------------------- ---------------------- =======================
- ------------------------------ ---------------------------------- ---------------------- =======================
Common Shares                  LaMont Asset Management                     3,759,069(2)          13.0%
                               Baarerstrasse 10
                               P.O. box 4639
                               6304 Zug, Switzerland

- ------------------------------ ---------------------------------- ---------------------- =======================
- ------------------------------ ---------------------------------- ---------------------- =======================
Common Shares                  Gwynn R. Williams                          3,475,188 (3)          11.8%
                               c/o Life Science Research Ltd.
                               3rd Floor Salisbury House
                               15 Victoria Street
                               Douglas, Isle of Man
                               British Isles, UK

- ------------------------------ ---------------------------------- ---------------------- =======================
- ------------------------------ ---------------------------------- ---------------------- =======================
Common Shares                  Trianon Opus One Inc.                          1,764,000           6.1%
                               Julius Baer Securities Inc.
                               330 Madison Avenue
                               New York, NY  10017

- ------------------------------ ---------------------------------- ---------------------- =======================
- ------------------------------ ---------------------------------- ---------------------- =======================
Common Shares                  John C. Klock                                 627,817(4)           2.2%
                               c/o  BioMarin Pharmaceutical
                               371 Bel Marin Keys Blvd. #210
                               Novato, CA  94949

- ------------------------------ ---------------------------------- ---------------------- =======================
- ------------------------------ ---------------------------------- ---------------------- =======================
Common Shares                  Christopher M. Starr                          15,944 (5)            *
                               c/o  BioMarin Pharmaceutical
                               371 Bel Marin Keys Blvd. #210
                               Novato, CA  94949

- ------------------------------ ---------------------------------- ---------------------- =======================
- ------------------------------ ---------------------------------- ---------------------- =======================
Common Shares                  John H. Craig                                 113,521(6)            *
                               c/o Cassels Brock & Blackwell,
                               Scotia Plaza, Suite 2100,
                               40 King Street West
                               Toronto, ON  M5H 3C2

- ------------------------------ ---------------------------------- ---------------------- =======================
- ------------------------------ ---------------------------------- ---------------------- =======================
Common Shares                  R. William Anderson                           92,520 (7)            *
                               c/o  BioMarin Pharmaceutical
                               371 Bel Marin Keys Blvd. #210
                               Novato, CA  94949

- ------------------------------ ---------------------------------- ---------------------- =======================

<PAGE>


                                      -4-

- ------------------------------ ---------------------------------- ---------------------- =======================
Common Shares                  John S. Glass                                109,000 (8)            *
                               Milkhaus Laboratory, Inc.
                               48 Main Street
                               Boxford, MA  01921

- ------------------------------ ---------------------------------- ---------------------- =======================
- ------------------------------ ---------------------------------- ---------------------- =======================
Common Shares                  Mark I. Young                                  42,000(9)            *
                               c/o Cassels Brock & Blackwell,
                               Scotia Plaza, Suite 2100, 40
                               King Street West,
                               Toronto, ON  M5H 3C2

- ------------------------------ ---------------------------------- ---------------------- =======================
- ------------------------------ ---------------------------------- ---------------------- =======================
Common Shares                  All Officers and Directors                 4,475,990(10)          15.1%

- ------------------------------ ---------------------------------- ---------------------- =======================

<FN>
* Less than 1%

(1) Includes  1,311,562  Common  Shares  issuable  upon exercise of common share
purchase  warrants.
(2) Includes 20,000 Common Shares issuable upon exercise of common share
purchase warrants.
(3) Includes 92,520 Common Shares issuable upon exercise of options within 60
days of January 28, 1999 and 312,568  Common  Shares  issuable  upon  exercise
of common share  purchase warrants.
(4) Includes  2,000 Common  Shares  issuable upon exercise of options
within 60 days of January 28, 1999.
(5) Includes  5,829 Common Shares  issuable upon  exercise of common share
purchase  warrants.
(6) Includes  68,520 Common Shares issuable upon exercise of options within 60
days of January 28, 1999.
(7)Includes  92,520 Common Shares  issuable upon exercise of options within 60
days of January 28, 1999.
(8) Includes 89,000 Common Shares issuable upon exercise of
options  within 60 days of January 28, 1999.
(9) Includes  41,000 Common Shares issuable  upon  exercise  of  options  within
60 days of January  28,  1999
(10)Includes  385,560 Common Shares issuable upon exercise of options within 60
days of January 28, 1999 and 318,397  Common Shares  issuable  upon  exercise of
common share  purchase warrants.  Excludes shares held by LaMont Asset
Management S.A., New York Life, and Trianon Opus One, Inc.
</FN>
</TABLE>

EXECUTIVE COMPENSATION

Summary Compensation Table

The following  table contains  information  about the  compensation  paid to, or
earned by, those who were, at December 31, 1998, the President,  Chief Executive
Officer and Chief Financial Officer of the Corporation and the Managing Director
of the  Corporation,  being  the  only  executive  officers  of the  Corporation
(collectively,  the "Named Executive  Officers") by the Corporation and BioMarin
Pharmaceutical  Inc.  ("BioMarin").  Specific aspects of their  compensation are
dealt with in further detail in subsequent tables.

<PAGE>


                                      -5-

Glyko Biomedical Ltd.:
<TABLE>

========================== ------- ========================================== ------------------ ===================
<CAPTION>

   Name and Principal                                                             Long-term          All Other
        Position           Year               Annual Compensation               Compensation        Compensation
                                                                                                      (U.S.$)
                                    ----------- ---------- ------------------ ------------------ -------------------

                                                             Other Annual      Securities Under
                                     Salary       Bonus      Compensation      Options Granted
                                     (U.S.$)     (U.S.$)        (U.S.$)              (#)
========================== ------- ------------ ---------- ------------------ ------------------ ===================
<S>                        <C>     <C>          <C>        <C>                <C>                <C>
John C. Klock
President, Chief
Executive Officer,
Chief Financial Officer,
and Director
                           1998         18,750     --             --                  11,290(2)          --
                           1997         97,226     --             --                  64,740(2)          --
                           1996        187,297     --             --                  75,876(2)          --
                           ------- ------------ ---------- ------------------ ------------------ ===================
========================== ------- ------------ ---------- ------------------ ------------------ ===================
Brian Bradley(1)
Managing Director          1998        101,602     --             --                 150,000(2)          --

========================== ------- ------------ ---------- ------------------ ------------------ ===================
<FN>

(1)  On April 1, 1998, Brian Bradley,  Ph.D. was appointed as Managing  Director of the Corporation and Christopher
    M. Starr, Ph.D. resigned as Vice President of Research and Development.
(2)  Options  were  assumed by BioMarin as part of the sale of Glyko,  Inc. on October 7, 1998.  See  "Interest  of
    Insiders in Material Transactions."
</FN>
</TABLE>

BioMarin Pharmaceutical, Inc.(1):
<TABLE>

========================== ------- ========================================== ------------------ ===================
<CAPTION>

   Name and Principal                                                             Long-term          All Other
        Position           Year               Annual Compensation               Compensation        Compensation
                                                                                                      (U.S.$)
                                                                                                 ===================
                                   ------------ ------------ ---------------- ------------------


                                                                              Securities Under
                                                              Other Annual     Options Granted
                                     Salary        Bonus      Compensation           (#)
                                     (U.S.$)      (U.S.$)        (U.S.$)
========================== ------- ------------ ------------ ---------------- ------------------ ===================
<S>                        <C>     <C>          <C>          <C>              <C>                <C>

John C. Klock              1998        222,450   87,500(2)         --              300,000               --
President  and Director    1997        146,914      --             --                --                  --
========================== ------- ------------ ------------ ---------------- ------------------ ===================

R. William Anderson        1998         90,484      --             --              200,000               --
Vice-President, Finance
and Administration and
Chief Financial Officer

========================== ======= ============ ============ ================ ================== ===================
<FN>

(1)   The Corporation.  owns 41% of BioMarin Pharmaceutical,  Inc. ("BioMarin").  Certain officers and directors of
     the Corporation are also officers and directors of BioMarin.
(2)   Includes amounts paid in 1999 for 1998.
</FN>
</TABLE>


<PAGE>


                                      -6-

Long-term Compensation Plans

Option Grants in 1998

Pursuant  to the  Corporation's  stock  option plan (the  "Plan"),  the Board of
Directors may from time to time  authorize the granting to directors,  officers,
employees  and  consultants  of the  Corporation  of options to  purchase  up to
3,000,000  Common Shares.  Granting of options in excess of the 3,000,000  share
maximum is subject to  shareholder  approval.  The exercise  price of any option
shall be fixed by the Board of  Directors  provided  that such  price may not be
less than the market price of the Common  Shares on the trading day prior to the
date of grant.  Payment of such exercise  price must be made in full at the time
of exercise.

Options  under  the  Plan  may be  granted  for any  term up to ten  years,  are
non-assignable,  and are subject to earlier  termination upon the termination of
an  optionee's  employment  for  any  cause  including   retirement,   permanent
disability but not death.  In the event of death of an optionee,  his estate may
be entitled for a period of six months thereafter to exercise any option which a
deceased  optionee would have been entitled to exercise if then alive but in any
event not after the date of  expiration of the option.  No  individual  may hold
options to purchase more than 5% of the number of Common Shares outstanding from
time to time.

The  purpose of the Plan is to attract and  motivate  the  directors,  officers,
employees and  consultants of the  Corporation and to advance the Corporation by
affording  such  persons the  opportunity  to acquire an equity  interest in the
Corporation.  In  determining  whether  options  will be  granted,  the Board of
Directors will review the financial position of the Corporation, the performance
of such individuals in carrying out their duties and their  willingness to serve
the needs of the  Corporation  in general and the general state of the financial
markets.

The  following  table  provides  details of stock  options  granted to the Named
Executive  Officers  during the fiscal year ended  December 31, 1998 pursuant to
the Plan.
<TABLE>

- ----------------------- --------------- ------------------- ------------------ ------------------ ===================
<CAPTION>
                                                                               Market Value of
                        Securities      % of Total                             Securities
                        Under Options   Options Granted                        Underlying
                        Granted         to Employees in     Exercise/Base      Options of the
Name                    (#)(1),         Financial Year      Price              Date of Grant
                                                            (Cdn.$/Security)   (Cdn.$/Security)   Expiration Date
- ----------------------- --------------- ------------------- ------------------ ------------------ ===================
- ----------------------- --------------- ------------------- ------------------ ------------------ ===================
<S>                     <C>             <C>                 <C>                <C>                <C>

John C.  Klock            11,290(2)             5%                $1.25              $1.25            31-DEC-02

- ----------------------- --------------- ------------------- ------------------ ------------------ ===================
- ----------------------- --------------- ------------------- ------------------ ------------------ ===================

Brian Bradley             150,000(2)           64%                $3.45              $3.45            31-MAR-03

- ----------------------- --------------- ------------------- ------------------ ------------------ ===================
<FN>

(1)   Securities Under Options Granted refers to Common Shares.
(2) Options Granted in 1998 were assumed by BioMarin as part of the Glyko,  Inc.
sale on October 7, 1998. </FN>
</TABLE>

<PAGE>


                                      -7-

Options Exercised and Options Remaining

The following table provides detailed information regarding options exercised by
the Named Executive  Officers and directors of the  Corporation  during 1998. In
addition, details on remaining options held are provided.
<TABLE>

========================= ------------- ------------- ==================================== ====================================
<CAPTION>
                                                                                                  Value of Unexercised
                                                            Unexercised Options at               in-the-money Options at
                                                               December 31, 1998                  December 31, 1998(1)

                                                      ---------------- ------------------- ----------------- ==================


                           Securities
                            Acquired     Aggregate
                          on Exercise      Value
                              (#)         Realized      Exercisable      Unexercisable       Exercisable     Unexercisable
          Name                            (Cdn.$)           (#)               (#)              (Cdn.$)            (Cdn.$)
========================= ------------- ------------- ---------------- ------------------- ----------------- ==================
<S>                       <C>           <C>           <C>              <C>                 <C>               <C>
R. William Anderson             20,000       $48,000           90,520          --                  $535,340         --
========================= ------------- ------------- ---------------- ------------------- ----------------- ==================
Brian Bradley (2)              --            --                28,125      121,875                 $92,812      $495,000
========================= ------------- ------------- ---------------- ------------------- ----------------- ==================
John H. Craig                   20,000       $48,000           90,520          --                  $535,340         --
========================= ------------- ------------- ---------------- ------------------- ----------------- ==================
John S. Glass                   20,000       $20,000           87,000          --                  $515,100         --
========================= ------------- ------------- ---------------- ------------------- ----------------- ==================
John C. Klock(2) (3)           534,672    $1,106,167          140,616          --                  $923,646         --
- ------------------------- ------------- ------------- ---------------- ------------------- ----------------- ==================
Gwynn R. Williams               20,000       $48,000           90,520          --                  $535,340         --
- ------------------------- ------------- ------------- ---------------- ------------------- ----------------- ==================
Mark I. Young                  --            --                39,000          --                  $140,300         --
========================= ------------- ============= ---------------- =================== ----------------- ==================
<FN>

(1) Based on the closing price of Common Shares on The Toronto Stock Exchange on
December 31, 1998 of $6.75.
(2) Options were assumed by BioMarin as part of the sale of Glyko,  Inc. on
October 7, 1998.
(3) These Common Shares  acquired were purchase by a loan from the Corporation.
See "Indebtedness of Directors, Executive Officers And Senior Officers."
</FN>
</TABLE>

COMPENSATION OF DIRECTORS

Each non-executive  Director of the Corporation received 16,000 stock options in
1998 at an exercise price of Cdn.$1.25  expiring on December 31, 2002 in lieu of
monetary compensation for services rendered in their capacity as directors.


<PAGE>


                                      -8-

PERFORMANCE GRAPH

The following graph compares the Company's cumulative total shareholder return 
with the cumulative total return of the TSE 300 Composite Index, assuming a $100
investment in Common Shares on December 31, 1993 and reinvestment of dividends
during the period. The period covered by the graph includes the fiscal years 
ended December 31, 1998, 1997, 1996, 1995 and 1994.



                       Dec-93   Dec-94   Dec-95   Dec-96    Dec-97   Dec-98

TSE 300.............   100      99.8     114.3    146.7     168.7     166
The Company.........   100      29.8      22.8     14.0      43.9     236.8



<PAGE>


                                      -9-

REPORT ON EXECUTIVE COMPENSATION

During the fiscal year ended  December  31,  1998,  the  Compensation  Committee
comprised  Messrs.  Anderson  and  Williams.  It is  the  responsibility  of the
Compensation  Committee to determine the level of compensation in respect of the
Corporation's  senior executives with a view to providing such executives with a
competitive  compensation  package having regard to performance.  Performance is
defined to include  achievement  of the  Corporation's  strategic  objective  of
growth and the enhancement of shareholder  value through  increases in the stock
price resulting from increases in sales and earnings in Glyko, Inc. and increase
in value in its holdings of BioMarin. In October 1998, the Corporation increased
its holdings in BioMarin by the sale of its wholly-owned subsidiary, Glyko, Inc.
to BioMarin  for a value of  U.S.$14.5  million.  See  "Interest  of Insiders in
Material Transactions."

Compensation for executive  officers is composed  primarily of three components;
namely,  base salary,  performance  bonuses and the  granting of stock  options.
Performance  bonuses are considered from time to time having regard to the above
referenced objectives.

In  establishing  the  levels of base  salary,  the award of stock  options  and
performance   bonuses  the  Compensation   Committee  takes  into  consideration
individual  performance,  responsibilities,  length  of  service  and  levels of
compensation provided by industry competitors.

Submitted by:

Mr. R. William Anderson
Mr. Gwynn Williams

PARTICULARS OF MATTERS TO BE ACTED UPON

Grant of Options

On July 15, 1996, the Corporation entered into an agreement with The Sage Group,
Inc.  (the  "Sage  Group")  whereby  the Sage  Group was  retained  to prepare a
valuation of the Corporation's analytical business and to assist the Corporation
with  the   divestiture  of  such   business.   In  addition  to  certain  other
consideration  to be paid to the Sage Group,  the Corporation  agreed to pay the
Sage Group a monthly fee of U.S.$7,500 from July to December 1996 and U.S.$5,000
from January to June 1997.

On October 25,  1996,  the  Corporation  agreed,  subject to the approval of The
Toronto Stock Exchange, to grant options to acquire 100,000 Common Shares of the
Corporation in  consideration of the reduction of the monthly retainer fee to be
paid to the Sage  Group by  October  1996 from June 1997 by  one-half,  being an
aggregate of  U.S.$26,250.  The options are  exercisable at an exercise price of
U.S.$0.50 per share at any time on or before  October 26, 2001.  Fifty  thousand
(50,000)  options were to vest upon approval of The Toronto  Stock  Exchange and
10,000  options were to vest on the last day of each calendar month for the five
months commencing October 1996.

<PAGE>


                                      -10-

The Toronto  Stock  Exchange has accepted  notice of the grant of options to the
Sage Group to purchase  100,000  Common  Shares at an exercise of U.S.$0.50  per
share expiring October 26, 2001,  subject to, among other things,  approval by a
majority of votes cast at a meeting of Shareholders.

Shareholders will be asked to consider and if deemed advisable pass a resolution
authorizing  and  approving  the  grant of  options  to the Sage  Group.  Unless
otherwise indicated, proxies in the enclosed form will be voted for the approval
of the  resolutions  relating  to the grant of  options to the Sage Group on any
ballot requested or required by law.

The text of the resolution  Shareholders  will be asked to consider is set forth
below.  The affirmative  vote of a majority of the votes cast in respect thereof
is required in order to pass such resolution.

"NOW THEREFORE BE IT RESOLVED THAT:

1.       The grant of options for  services  performed by The Sage Group Inc. to
         purchase an aggregate of 100,000 Common Shares of the Corporation at an
         option  exercise  price of U.S.$0.50 per share on or before October 26,
         2001 is hereby authorized and approved.

2.       Any one  officer or  director  of the  Corporation  be and he is hereby
         authorized  and  directed,  acting for, in the name of and on behalf of
         the Corporation,  to execute or cause to be executed, under seal of the
         Corporation  or otherwise and to deliver or cause to be delivered,  all
         such other deeds,  documents,  instruments  and assurances and to do or
         cause to be done all such other acts and  things,  as in the opinion of
         such director or officer may be necessary or desirable to carry out the
         terms of the foregoing resolution."

Re-Pricing of Certain Options Held by Insiders

On December 10, 1992, the  Corporation  granted options to purchase an aggregate
of 657,000 Common Shares of the Corporation to directors, officers and employees
at an exercise  price of  Cdn.$2.75  per share on or before  December  31, 1998.
Effective August 3, 1994, the Board of Directors of the Corporation approved the
re-pricing  of 473,000 of such  options from $2.75 per share to $1.00 per share,
the market price of the Common Shares on August 3, 1994. An aggregate of 300,000
of such  re-priced  options had been  granted to officers  and  directors of the
Corporation  (the  "Insiders")  of which 150,000 had been granted to Christopher
Starr,  Vice President,  Research and Development of the Corporation and 150,000
had been granted to John  Hamilton,  the former Chief  Financial  Officer of the
Corporation.  As of  the  date  hereof,  300,000  re-priced  options  have  been
exercised by the Insiders.

The Toronto Stock  Exchange has accepted the notice of amendment to the exercise
price of the 300,000  re-priced  options held by the Insiders  subject to, among
other things, the approval of Shareholders  holding a majority of the votes cast
at a meeting of Shareholders, other than votes attached to Common Shares held by
the Insiders and their associates.

<PAGE>


                                      -11-

Shareholders will be asked to consider and if deemed advisable pass a resolution
authorizing  and approving  the  re-pricing  of 300,000  options  granted to the
Insiders and  ratifying the exercise of 300,000 of such options by the Insiders.
Unless otherwise  indicated,  proxies in the enclosed form will be voted for the
approval of the resolution on any ballot requested or required by law.

An aggregate of 89,510  Common  Shares held by the Insiders will not be eligible
to vote  of this  resolution.  As a  result,  28,860,519  Common  Shares  of the
Corporation may be voted.

The text of the resolution  that  Shareholders  will be asked to consider is set
forth  below.  The  affirmative  vote of a majority of the votes cast in respect
thereof,  other than votes cast by the Insiders and their respective associates,
is required in order to pass such resolution:


"NOW THEREFORE BE IT RESOLVED THAT:

1.       The amendment to the exercise price of an aggregate of 300,000  options
         to purchase  Common Shares of the Corporation on or before December 31,
         1998  granted to certain  insiders  of the  Corporation  from $2.75 per
         share to $1.00 per share is hereby authorized and approved.

2.       The  exercise of an  aggregate  of 300,000  options to purchase  Common
         Shares of the  Corporation  at an exercise  price of $1.00 per share by
         certain insiders of the Corporation is hereby ratified and approved.

3.       Any one  officer or  director  of the  Corporation  be and he is hereby
         authorized  and  directed,  acting for, in the name of and on behalf of
         the Corporation,  to execute or cause to be executed, under seal of the
         Corporation  or otherwise and to deliver or cause to be delivered,  all
         such other deeds,  documents,  instruments  and assurances and to do or
         cause to be done all such other acts and  things,  as in the opinion of
         such director or officer may be necessary or desirable to carry out the
         terms of the foregoing resolution."

INTEREST OF INSIDERS IN MATERIAL TRANSACTIONS

To the  best  of the  Corporation's  knowledge,  none of the  directors,  senior
officers  and  principal  shareholders  of the  Corporation  or  any  respective
associates  or  affiliates  of  any  director,   senior   officer  or  principal
shareholder  of the  Corporation  had any  direct or  indirect  interest  in any
material  transactions  of the  Corporation  entered into since January 1, 1998,
save and except that:

On October 7, 1998, the Corporation  sold 100% of the outstanding  capital stock
of Glyko,  Inc. to BioMarin.  As  consideration  for such sale,  BioMarin issued
2,259,039  shares of common  stock of  BioMarin  to the  Corporation,  agreed to
assume  options to purchase up to 585,969  Common  Shares  (which  options  were
previously issued to employees of Glyko,  Inc.) and paid the Corporation $500 in
cash. The shares of BioMarin common stock were valued

<PAGE>


                                      -12-

at $6.00 per  share,  yielding a total  value of  $13,554,234,  and the  options
assumed were valued at $945,765,  which,  when  combined  with the $500 in cash,
yields a total value for the consideration received of $14,500,499.  As a result
of the sale of Glyko,  Inc.  the  Corporation's  ownership  interest in BioMarin
increased to 41%. In conjunction  with the sale of Glyko,  Inc., the Corporation
converted  approximately  U.S.$3.8  million  of  intercompany  loan to equity in
Glyko,  Inc.  The  remaining  balance  of  U.S.$1.2  million  was  repaid to the
Corporation in cash.

Mr. R. William  Anderson,  a Director of the Corporation,  is also an officer of
BioMarin and on June 22, 1998, was granted an option to purchase 200,000 shares
of BioMarin's common stock at an exercise price of $4.00 per share.

                            INDEBTEDNESS OF DIRECTORS
                     EXECUTIVE OFFICERS AND SENIOR OFFICERS

Other than as described below, no director,  senior officer or executive officer
of the  Corporation  or associate of any director,  senior  officer or executive
officer is, or at any time since the  beginning of the most  recently  completed
financial year has been, indebted to the Corporation.

Pursuant to the Share Exchange Agreement under which the Corporation sold Glyko,
Inc. to BioMarin, the Corporation has loaned Cdn.$1,106,167 to Dr. John Klock to
purchase  Common  Shares of the  Corporation  upon the exercise of stock options
held by Dr.  Klock as set forth  below.  The loans are  evidenced by an interest
bearing promissory notes due on demand.

The following table sets forth any indebtedness of directors, senior officers or
executive  officers  of the  Corporation  entered  into in  connection  with the
purchase of securities of the Corporation.
<TABLE>

- ------------------------------------------------------------------------------------------------------===================
<CAPTION>
                                                                  Outstanding
                                                               Indebtedness as of   Number of Common
                                         Largest Amount of     December 31, 1998    Shares Purchased
 Name of Borrower                           Outstanding                                                  Security for
                          Lender            Indebtedness                                                 Indebtedness

- ------------------------------------------------------------------------------------------------------===================
- ------------------------------------------------------------------------------------------------------===================
<S>                    <C>                 <C>                   <C>                    <C>           <C>
John C. Klock          Corporation         Cdn.$1,106,167        Cdn.$1,106,167         532,672       532,672 Common
                                                                                                      Shares
- ------------------------------------------------------------------------------------------------------===================
</TABLE>

During  fiscal  1997 Dr.  Klock  purchased  800,000  shares of  common  stock of
BioMarin in exchange for a note  maturing on July 31, 2000.  The note is secured
by the underlying stock.


<PAGE>


                                      -13-

APPROVAL

The contents of this Management  Information Circular and the sending thereof to
the  Shareholders  have  been  authorized  by  the  Board  of  Directors  of the
Corporation.


DATED at Toronto this 28th day of January, 1999.



/s/John C.Klock
John C. Klock, M.D.
President and
Chief Executive Officer







                              GLYKO BIOMEDICAL LTD.
                            Scotia Plaza, Suite 2100
                               40 King Street West
                            Toronto, Ontario M5H 3C2
                                     Canada

            FORM OF PROXY SOLICITED BY THE MANAGEMENT FOR USE AT THE
                   SPECIAL MEETING OF SHAREHOLDERS TO BE HELD
                                 MARCH 10, 1999

The undersigned  Shareholder(s)  of GLYKO BIOMEDICAL LTD. hereby appoint(s) John
C. Klock,  President and Chief Executive Officer,  or failing him John H. Craig,
Secretary, or failing him, Mark I. Young, Assistant-Secretary, or in lieu of the
foregoing_________________________ as  nominee  of the  undersigned  to  attend,
act and  vote  for the undersigned at the Special Meeting of the  Shareholders 
of the Corporation to be held on the 10th day of March,  1999,  and at any 
adjournment  or  adjournments thereof to the same  extent and with the same 
power as if the  undersigned  was present at the Special  Meeting or adjournment
or  adjournments  thereof  and, without  limiting the  generality  of the power
hereby  conferred,  the nominees designated above are directed to:

(a)   VOTE  FOR ( ) VOTE AGAINST ( )  a resolution authorizing the grant
                                      of options to purchase 100,000
                                      common shares of the Corporation at
                                      a price of U.S.$0.50 per share
                                      expiring on October 25, 2001;

(b)   VOTE  FOR ( ) VOTE AGAINST ( )  a resolution authorizing the
                                      re-pricing of options previously
                                      granted on December 10, 1992
                                      to certain insiders of the
                                      Corporation to purchase 300,000
                                      common shares of the Corporation
                                      from an exercise price of Cdn$2.75
                                      per share to Cdn.$1.00 per share and
                                      ratifying the exercise of such options;

(c)  VOTE  FOR ( )  VOTE AGAINST ( )  on such other matters as may come
                                      properly before the Special Meeting:

hereby revoking any proxy previously given.

If any  amendments or variations to matters  identified in the Notice of Special
Meeting are proposed at the Special  Meeting or any  adjournment or adjournments
thereof or if any other matters  properly come before the Special Meeting or any
adjournment or adjournments thereof, this proxy confers discretionary  authority
to vote on such amendments or variations or such other matters  according to the
best  judgment  of the  person  voting the proxy at the  Special  Meeting or any
adjournment or adjournments thereof.

This proxy is solicited by the Management of the Corporation.  A Shareholder has
the right to appoint a person to represent  him and to attend and act for him on
his behalf at the Special  Meeting or any  adjournment or  adjournments  thereof
other than the nominees designated above and may exercise such right by striking
out the names of the  persons  designated  above and  inserting  the name of his
nominee in the blank space provided above for that purpose.


<PAGE>


                                      -2-


DATED the       day of               , 1999.


Signature of Shareholder(s)


Name(s) of Shareholder(s)
(Please Print)


Number of Shares Represented
by this Proxy

Notes:

1.  This  form of proxy  must be dated  and  signed  by the  Shareholder  or his
attorney authorized in writing or, if the Shareholder is a body corporate,  this
form of proxy  must be  executed  under its  corporate  seal or by an officer or
attorney thereof duly authorized.

2. The shares  represented by this proxy will be voted, voted for, withheld from
voting or voted against in accordance  with the  instructions of the Shareholder
on any ballot that may be called for. Where no  specification is made to vote or
withhold  from  voting in respect of the grant of  options  or the  approval  of
option re-pricing and ratification of exercise of such options, the nominees are
directed to vote the shares represented by this proxy.

3. This proxy ceases to be valid one year from its date.

4. Please date the proxy. If not dated, the proxy shall be deemed to be dated on
the day on which it is mailed.

5. If your address as shown is incorrect,  please give your correct address when
returning this proxy.

Return all forms of proxy to:

Montreal Trust Company of Canada
151 Front Street West, 8th Floor
Toronto, Ontario  M5J 2N1
Canada


© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission