MUNICIPAL INVT TR FD MULTISTATE SER 75 DEFINED ASSET FUNDS
24F-2NT, 1997-02-24
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                           FORM 24F-2
                Annual Notice of Securities Sold
                     Pursuant to Rule 24f-2

1.  Name and address of issuer:

Merrill Lynch, Pierce, Fenner & Smith Incorporated
c/o Merrill Lynch, Pierce, Fenner & Smith Incorporated
Defined Asset Funds
P.O. Box 9051
Princeton, N.J. 08543-9051

2.  Name of each series or class of fund for which this notice is 
filed:

     Municipal Investment Trust Fund, Multistate Series-75, 
Defined Asset Funds

3.  Investment Company Act File Number:
     811-1777

    Securities Act File Number:
     33-55781

4.  Last day of fiscal year for which this notice is filed:
     December 31, 1996

5.  Check box if this notice is being filed more than 180 days 
after the close of the issuer's fiscal year for purposes of 
reporting securities sold after the close of the fiscal year but 
before termination of the issuer's 24f-2 declaration:

     [ ]

6.  Date of termination of issuer's declaration under rule 24f-
2(a)(1), if applicable (see Instruction A.6): 

     Not Applicable

7.  Number and amount of securities of the same class or series 
which had been registered under the Securities Act of 1933 other 
than pursuant to rule 24f-2 in a prior fiscal year, but which 
remained unsold at the beginning of the fiscal year:

     None

8.  Number and amount of securities registered during the fiscal 
year other than pursuant to rule 24f-2:

     None

9.  Number and aggregate sale price of securities sold during the 
fiscal year:

     1,286 Units                   $1,346,370.47 Aggregate Sale Price

10. Number and aggregate sale price of securities sold during the fiscal 
year in reliance upon registration pursuant to rule 24f-2:

     1,286 Units                   $1,346,370.47 Aggregate Sale Price

11. Number and aggregate sale price of securities issued during the fiscal 
year in connection with dividend reinvestment plans, if applicable (see 
Instruction B.7):

     Not Applicable

12. Calculation of registration fee:

     (i)  Aggregate sale price of securities sold 
     during the fiscal year in reliance on rule 
     24f-2 (from item 10):                               $1,346,370.47

     (ii) Aggregate price of shares issued in 
     connection with dividend reinvestment plans 
     from Item 11, if applicable):                             N/A


     (iii) Aggregate price of shares redeemed or
     repurchased during the fiscal year (if 
     applicable):                                           $2,180,449.
     41

     (iv) Aggregate price of shares redeemed or 
     repurchased and previously applied as a 
     reduction to filing fees pursuant to rule 24f-
     2 (if applicable):                                           $0.00

     (v) Net aggregate price of securities sold and 
     issued during the fiscal year in reliance on 
     rule 24f-2 [line (i), plus line (ii), less 
     line (iii), plus line (vi)] (if applicable):        $0.00

     (vi) Multiplier prescribed by Section 6(b) of 
     the Securities Act of 1933 or other applicable 
     law or regulation (see Instruction C.6):             1/33rd of 1%
                                                        _____________
                                                          $0.00
                                                     ================

13.  Check box if fees are being remitted to the Commissions's 
lockbox depository as describe in section 3a of the Commission's 
Rules of Informal and Other Procedures (17 CFR 202.3a).

     []

     Date of mailing or wire transfer of filing fees to the 
Commission's lockbox depository:

     Not Applicable

                           SIGNATURES

This report has been signed below by the following persons on 
behalf of the issuer and in the capacities and on the dates 
indicated.

                        By Merrill Lynch, Pierce, Fenner & Smith 
                        Incorporated


                        By /s/ Daniel C. Tyler
                              Vice-President


Date:  February 24, 1997


                              Davis Polk & Wardwell
                              450 Lexington Avenue
                            New York, New York 10017
                                 (212) 450-4000




                                           February 24, 1997



        Merrill Lynch, Pierce, Fenner &
          Smith Incorporated as Agent
          for the Sponsors of certain
          Unit Investment Trusts
        800 Scudders Mill Road
        Plainsboro, New Jersey 08536


        Dear Sirs:


                  We have acted as special counsel for you and the other 
        Sponsors of Municipal Investment Trust Fund, Multistate 
        Series-75, Defined Asset Funds (the "Fund"), in connection with 
        the issuance of units of fractional undivided interest in the 
        Fund (the "Units") in accordance with the related Trust Indenture 
        (the "Indenture") with The Bank of New York as trustee (the 
        "Trustee"). The accompanying Rule 24f-2 Notice (the "Notice") for 
        the Fund makes definite in number the registration of Units sold 
        in reliance upon the Rule during the fiscal period covered by the 
        Notice.  The Units covered by the Notice are hereinafter referred 
        to as the "Registered Units".

             We have examined and are familiar with originals or copies, 
        certified or otherwise identified to our satisfaction, of such 
        documents and instruments as we have deemed necessary or 
        advisable for the purpose of this opinion.

             Based upon the foregoing, we are of the opinion that the 
        Registered Units, assuming due execution and delivery of any 
        certificates evidencing the Registered Units by the Sponsor and 
        the Trustee and assuming payment for all registered Units in 
        accordance with the Indenture, have been legally issued and are 
        fully-paid and non-assessable.

                                           Very truly yours,


                                           /s/ Davis Polk & Wardwell



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