EPOCH PHARMACEUTICALS INC
SC 13D, 1996-10-08
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549


                                  SCHEDULE 13D
                              (Amendment No. ____)*

                    Under the Securities Exchange Act of 1934


                           EPOCH PHARMACEUTICALS, INC.
                                (Name of Issuer)

                                  COMMON STOCK
                         (Title of Class of Securities)

                                   294273 10 7
                                 (CUSIP Number)

                                Emanuel J. Adler
                              Tenzer Greenblatt LLP
                              405 Lexington Avenue
                            New York, New York 10174
                                 (212) 885-5565
       (Name, Address and Telephone Number of Person Authorized to Receive
        Notice and Communications)

                                  June 21, 1996
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box |_|.

Check the following box if a fee is being paid with the  statement.|_| (A fee is
not required only if the reporting person:  (1) has a previous statement on file
reporting  beneficial  ownership  of more  than  five  percent  of the  class of
securities  described  in Item 1;  and (2) has  filed  no  amendment  subsequent
thereto reporting  beneficial  ownership of five percent or less of such class.)
(See Rule 13d-7).

Note: Six copies of this statement, including all exhibits, should be filed with
the  Commission.  See Rule  13d-1(a) for other  parties to whom copies are to be
sent.

* The remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


                               Page 1 of 33 Pages


<PAGE>
                                  SCHEDULE 13D
CUSIP No.294273 10 7                                          Page 2 of 33 Pages



- --------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

          MOSES MARX


- --------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [X]
                                                             (b)  [ ]


- --------------------------------------------------------------------------------
   3   SEC USE ONLY




- --------------------------------------------------------------------------------
   4   SOURCE OF FUNDS*

          N/A


- --------------------------------------------------------------------------------
   5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
       ITEMS 2(d) OR 2(e)                                         [  ]


- --------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

          UNITED STATES


- --------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
     SHARES            750,000
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      8    SHARED VOTING POWER
      EACH             --
   REPORTING      --------------------------------------------------------------
     PERSON       9    SOLE DISPOSITIVE POWER
      WITH             750,000
                  --------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                       --

- --------------------------------------------------------------------------------
  11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        750,000

- --------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [  ]

- --------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

       5.2%

- --------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*

       IN


- --------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEM 1-7 (INCLUDING EXHIBITS)
OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.

                               Page 2 of 33 Pages

<PAGE>


                                  SCHEDULE 13D
CUSIP No. 294273 10 7                                         Page 3 of 33 Pages




- --------------------------------------------------------------------------------
   1   NAME OF REPORTING PERSON
       S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

          UNITED EQUITIES (COMMODITIES) COMPANY

- --------------------------------------------------------------------------------
   2   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                             (a)  [X]
                                                             (b)  [ ]


- --------------------------------------------------------------------------------
   3   SEC USE ONLY




- --------------------------------------------------------------------------------
   4   SOURCE OF FUNDS*

          WC


- --------------------------------------------------------------------------------
   5   CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
       ITEMS 2(d) OR 2(e)                                         [  ]


- --------------------------------------------------------------------------------
   6   CITIZENSHIP OR PLACE OF ORGANIZATION

          NEW YORK


- --------------------------------------------------------------------------------
   NUMBER OF      7    SOLE VOTING POWER
     SHARES            750,000
  BENEFICIALLY    --------------------------------------------------------------
    OWNED BY      8    SHARED VOTING POWER
      EACH             --
   REPORTING      --------------------------------------------------------------
     PERSON       9    SOLE DISPOSITIVE POWER
      WITH             750,000
                  --------------------------------------------------------------
                  10   SHARED DISPOSITIVE POWER
                       --

- --------------------------------------------------------------------------------
  11   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

        750,000

- --------------------------------------------------------------------------------
  12   CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

                                                                      [  ]

- --------------------------------------------------------------------------------
  13   PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

       5.2%

- --------------------------------------------------------------------------------
  14   TYPE OF REPORTING PERSON*

       PN, BD


- --------------------------------------------------------------------------------
                     *SEE INSTRUCTIONS BEFORE FILLING OUT!

INCLUDE BOTH SIDES OF THE COVER PAGE, RESPONSES TO ITEM 1-7 (INCLUDING EXHIBITS)
OF THE SCHEDULE, AND THE SIGNATURE ATTESTATION.


                               Page 3 of 33 Pages
<PAGE>


Item 1. Security and Issuer.

        This  statement  relates to shares of Common  Stock,  $.01 par value per
        share, of Epoch  Pharmaceuticals,  Inc. (the  "Company").  The principal
        executive  offices of the Company  are located at 1725 220th  Street SE,
        104, Bothell, Washington 98021.


Item 2. Identity and Background

        (a)  Pursuant  to Rule  13d-1(f)(1)  promulgated  under  the  Securities
        Exchange Act of 1934, as amended (the "Exchange Act"), this Schedule 13D
        is  being  filed  by Moses  Marx,  an  individual  and  United  Equities
        (Commodities)  Company, a partnership  ("United Equities  Commodities").
        Mr.  Marx and  United  Equities  Commodities  (collectively  called  the
        "Reporting  Persons") are making this single,  joint filing because they
        may be deemed to  constitute  a "group"  within  the  meaning of Section
        13(d)(3) of the Exchange Act.

        (b) - (c)

        Moses Marx

        Mr. Marx is principally employed as a securities and commodities broker.
        Mr. Marx conducts his securities  brokerage  business in United Equities
        Company,  a  partnership  ("United   Equities"),   and  his  commodities
        brokerage business in United Equites Commodities. The principal business
        address  of each of Mr.  Marx and  United  Equities  Commodities  is 160
        Broadway, New York, New York 10038.

        United Equities Commodities

        United  Equities  Commodities  is a  partnership  which is a  registered
        commodities  broker.  The principal  business address of United Equities
        Commodities  is 160  Broadway,  New York,  New York  10038.  Pursuant to
        Instruction C to Schedule 13D, the general  partners of United  Equities
        Commodities  are Moses  Marx,  who has a 99% equity  interest  in United
        Equities Commodities, and Phillippe Katz and Dr. Joseph M. Fink, each of
        whom has a .5% equity interest in United Equities Commodities. Mr. Marx'
        business address and present  principal  occupation are set forth above.
        Mr. Katz's business  address is 160 Broadway,  New York, New York 10038.
        Mr.  Katz is  principally  employed  as a  securities  broker  at United
        Equities Commodities at the address indicated above. Dr. Fink's business
        address is 501 Madison Avenue, New York,


                               Page 4 of 33 Pages

<PAGE>


        New York 10022. Dr. Fink is principally employed as a periodontist.

        (d) To the best knowledge of the Reporting Persons, during the last five
        years,  none of the Reporting  Persons has been  convicted in a criminal
        proceeding (excluding traffic violations or similar misdemeanors).

        (e) To the best knowledge of the Reporting Persons, during the last five
        years,  none  of the  Reporting  Persons  has  been a  party  to a civil
        proceeding   of  a  judicial  or   administrative   body  of   competent
        jurisdiction  and is  subject  to any  judgment,  decree or final  order
        enjoining future  violations of, or prohibiting or mandating  activities
        subject  to,  federal  or  state  securities  laws or a  finding  of any
        violation with respect to such laws.

        (f) Each of the  individuals  named in this Item 2 is a  citizen  of the
        United States of America.

Item 3. Source and Amount of Funds or Other Consideration.

        The source of the funds used by United Equities  Commodities to purchase
        500,000  shares of Common Stock and 500,000  Class C  Redeemable  Common
        Stock Purchase Warrants (the "Warrants"), which Warrants are exercisable
        to purchase 250,000 shares of Common Stock at an exercise price of $1.25
        per 1/2 share,  reported in Item 5, was working  capital.  The shares of
        Common  Stock and the  Warrants  were  purchased  on June 21,  1996 at a
        purchase price of $500,000.00.

Item 4. Purpose of Transaction.

        The Reporting  Persons acquired the Common Stock and the Warrants of the
        Company  reported  herein as being owned by each of them for  investment
        purposes.  Depending upon market  conditions and other factors that each
        of  the  Reporting   Persons  may  deem  material  to  their  respective
        investment  decisions,  the  Reporting  Persons may purchase  additional
        shares of Common Stock and/or Warrants of the Company in the open market
        or in private  transactions,  or may  dispose of all or a portion of the
        shares of Common Stock and/or Warrants of the Company that each now owns
        or hereafter  may acquire.  Except as otherwise  set forth  herein,  the
        Reporting  Persons have no plans or proposals  which relate to, or could
        result in any of the matters  referred to in Paragraphs  (b) through (j)
        of Item 4 of Schedule 13D.


                               Page 5 of 33 Pages

<PAGE>


Item 5. Interest in Securities of the Issuer.

        (a) - (b)

        According  to the  Company's  Quarterly  Report  on Form 10- QSB for the
        period ended June 30, 1996, there were, as of July 30, 1996,  14,266,713
        shares of Common Stock of the Company issued and outstanding.

        Moses Marx

        Moses Marx beneficially  owns 750,000 shares of Common Stock,  comprised
        of 500,000 shares and shares issuable upon exercise of 500,000 Warrants,
        each to purchase,  at any time until June 20, 2001,  1/2 share of Common
        Stock at a purchase price of $1.25 per 1/2 share, comprising 5.2% of the
        issued and outstanding  shares of the Common Stock.  With respect to the
        shares  described  herein , Mr.  Marx may be deemed  to be a  beneficial
        owner by virtue of his being the only person in a position to  determine
        the investment and voting decisions of United Equities  Commodities with
        respect to such shares.

        Mr. Marx has the sole power to vote and dispose of all such shares.

        United Equities  Commodities.  United Equities  Commodities owns 750,000
        shares of Common Stock,  comprised of 500,000 shares and shares issuable
        upon exercise of 500,000 Warrants,  each to purchase 1/2 share of Common
        Stock at a purchase price of $1.25 per 1/2 share, comprising 5.2% of the
        issued and outstanding shares of the Common Stock.

        United  Equities  Commodities  has the sole power to vote and dispose of
        all such shares.

        (c) During the  period  since June 21,  1996 and other than as set forth
        above,  neither Mr. Marx nor United  Equities  Commodities  effected any
        transactions in the Shares.

        (d) Each of the Reporting  Persons affirms that no person other than the
        Reporting  Persons has the right to receive,  or the power to direct the
        receipt of dividends  from, or the proceeds from the sale of, the Common
        Stock owned by the Reporting Persons.

        (e) It is  inapplicable  for the  purposes  herein  to state the date on
        which the  Reporting  Persons  ceased to be the owners of more than five
        percent of the Common Stock.


                               Page 6 of 33 Pages

<PAGE>


Item 6. Contracts, Arrangements, Understandings or Relationships with respect to
        Securities of the Issuer.

        The  Warrants  are callable by the company upon the terms and subject to
        the  conditions set forth in the Warrant  Agreement  between the Company
        and American Stock Transfer & Trust Company, a copy of which is files as
        an exhibit to this 13D.

        Except  as set forth  elsewhere  in this  Schedule  13D,  the  Reporting
        Persons  do  not  have  any  contract,  arrangement,   understanding  or
        relationship  (legal or  otherwise)  with any person with respect to any
        securities of the Company,  including,  but not limited to,  transfer or
        voting of any such securities,  finders' fees,  joint ventures,  loan or
        option arrangements,  puts or calls, guarantees of profits,  division of
        profits or losses, or the giving or withholding of proxies.

Item 7. Material to be Filed as Exhibits.

        1. Agreement dated June 21, 1996 among the Reporting Persons relating to
        the filing of a joint statement pursuant to Rule 13d-1(f)(1).

        2.  Warrant  Certificate  No.  WWC-051  of Epoch  Pharmaceuticals,  Inc.
        representing  the  right of United  Equities  (Commodities)  Company  to
        purchase shares of Common Stock.

        3. Warrant  Agreement between Epoch  Pharmaceuticals,  Inc. and American
        Stock Transfer & Trust Company.


                               Page 7 of 33 Pages

<PAGE>


                                    SIGNATURE




        After reasonable  inquiry,  and to the best of our knowledge and belief,
the  undersigned  certify that the  information  set forth in this  statement is
true, complete and correct.

Date: October 7, 1996


                                           /s/ Moses Marx
                                           -------------------------------------
                                           MOSES MARX


                                           UNITED EQUITIES (COMMODITIES) COMPANY


                                           By: /s/ Moses Marx
                                               ---------------------------------
                                               Moses Marx, General Partner



                               Page 8 of 33 Pages

<PAGE>


                                  Exhibit Index
                                  -------------

                                                                      Sequential
Exhibit No.              Description                                    Page No.
- -----------              -----------                                    --------

    1          Agreement dated June 21, 1996                               10
               among the Reporting Persons
               relating to filing of a joint
               acquisition statement pursuant to
               Rule 13d - 1(f)(1).

    2          Warrant Certificate No. WWC-051 of                          11
               Epoch Pharmaceuticals, Inc.
               representing   the   right   of   United   Equities
               (Commodities)  Company to purchase shares of Common
               Stock.

    3          Warrant Agreement between Epoch,                            16
               Pharmaceuticals, Inc. and American
               Stock Transfer & Trust Company.






                               Page 9 of 33 Pages



                                                                       Exhibit 1



        The  undersigned  hereby agree,  pursuant to Rule 13d- 1(f)(1) to file a
joint  statement  on Schedule 13D and  amendments  thereto  pertaining  to their
shares  of  Common   Stock  and  Common   Stock   Purchase   Warrants  of  Epoch
Pharmaceuticals, Inc.

        This  agreement  may be  terminated  for any reason by any party  hereto
immediately  upon the personal  delivery or facsimile  transmission of notice to
that effect to the other parties hereto.

        This agreement may be executed in counterparts and all so executed shall
constitute one agreement.

Date: June 21, 1996


                                           /s/ Moses Marx
                                           -------------------------------------
                                           MOSES MARX


                                           UNITED EQUITIES (COMMODITIES) COMPANY


                                           By: /s/ Moses Marx
                                               ---------------------------------
                                               Moses Marx, General Partner




                               Page 10 of 33 Pages



                                                                       EXHIBIT 2
 WCC-051                      WARRANT CERTIFICATE

                            CERTIFICATE FOR WARRANTS

              NOT EXERCISABLE AFTER 5:00 P.M., NEW YORK CITY TIME,
                                ON JUNE 20, 2001


                           EPOCH PHARMACEUTICALS, INC.

          CLASS C REDEEMABLE COMMON STOCK PURCHASE WARRANT CERTIFICATE


THIS CERTIFIES that


                       United Equities Commodities Company


or registered assigns is the registered holder (the "Registered Holder") of five
hundred  thousand  (500,000)  Warrants,  each of which  represents  the right to
purchase one-half (1/2) fully paid and nonassessable  share of Common Stock, par
value $.01 per share (the  "Common  Stock") of Epoch  Pharmaceuticals,  Inc.,  a
Delaware  corporation (the "Company"),  at the initial exercise price ("Exercise
Price") of $1.25 per one-half  share at any time,  but not after the  Expiration
Date hereinafter referred to, by surrendering this Warrant Certificate, with the
form of  election  to  purchase  set forth  hereon  duly  executed at the office
maintained  pursuant to the Warrant Agreement  hereinafter  referred to for that
purpose by American Stock Transfer & Trust Company,  or its successor as warrant
agent (any such warrant agent being herein called the "Warrant  Agent"),  and by
paying in full the Exercise Price,  plus transfer taxes, if any.  Payment of the
Exercise Price shall be made in United States  currency,  by certified  check or
money order payable to the Warrant Agent for the account of the Company.

        The Warrants are subject to call for  redemption by the Company upon not
less than 30 days' nor more  than 60 days'  notice at a call  price of $0.05 per
warrant (the "Call Price"),  at any time after 9:30 A.M., New York City time, on
December 20, 1997,  provided  that  closing sale price of the Common  Stock,  as
determined  pursuant to Section 4.2 of the Warrant  Agreement,  dated as of June
21, 1996,  between the Company and the Warrant Agent (the "Warrant  Agreement"),
shall  have  been at least  150% of the  then  effective  exercise  price of the
Warrants,  as adjusted  pursuant to Section  4.8 of the Warrant  Agreement  (the
"Call  Trigger  Price"),  for a period of 20  consecutive  business  days ending
within 15 days of the date that the notice of such call (the "Call  Notice")  is
given by the  Company to the  Warrant  Agent  pursuant  to  Section  4.11 of the
Warrant  Agreement,  and  provided  further  that the Company has  complied  and
continues to be in compliance  with the provisions of Section 2.2 of the Warrant
Agreement.


                               Page 11 of 33 Pages

<PAGE>




        No Warrant may be executed  after 5:00 P.M.,  New York City time, on the
expiration  date (the  "Expiration  Date") which will be the earlier of June 20,
2001 or the business day preceding the call date specified in a Call Notice. All
Warrants evidenced hereby shall thereafter become void.

        Prior to the Expiration  Date,  subject to any applicable laws, rules or
regulations   restrictions   transferability   and   to   any   restriction   on
transferability  that may appear on this Warrant  Certificate in accordance with
the terms of the Warrant  Agreement,  the Registered Holder shall be entitled to
transfer this Warrant  Certificate,  in whole or in part, upon surrender of this
Warrant  Certificate  at the office of the  Warrant  Agent  maintained  for that
purpose  with the form of  assignment  set  forth  hereon  duly  executed,  with
signatures  guaranteed  by a member firm of a national  securities  exchange,  a
commercial  bank or a trust company  located in the United States or a member of
the National Association of Securities Dealers, Inc. or other eligible guarantor
institution  which is a participant  in a signature  guarantee  program (as such
terms are defined in Reg. 240.17Ad-15 under the Securities Exchange Act of 1934,
as amended),  acceptable to the Warrant  Agent.  Upon any such  transfer,  a new
Warrant  Certificate  or Warrant  Certificates  representing  the same aggregate
number of Warrants will be issued in accordance with instructions in the form of
assignment.

        Upon the  exercise of less than all of the  Warrants  evidenced  by this
Warrant  Certificate,  there  shall be  issued  to the  Registered  Holder a new
Warrant Certificate in respect of the Warrants not exercised.

        Prior to the Expiration Date, the Registered Holder shall be entitled to
exchange this Warrant  Certificate  with or without prior Warrant  Certificates,
for another  Warrant  Certificate or Warrant  Certificates of the same aggregate
number of Warrants  upon  surrender  of this Warrant  Certificate  at the office
maintained for such purpose by the Warrant Agent.

        Upon certain events  provided for in the Warrant  Agreement  hereinafter
referred to the Exercise  Price,  the number of shares of Common Stock  issuable
upon the exercise of each Warrant and the Call Trigger  Price are required to be
adjusted.

        No fractional shares will be issued upon the exercise of Warrants. As to
any final fraction of a share which the registered holder of one or more Warrant
Certificates,  the rights  under which are  exercised  in the same  transaction,
would  otherwise be entitled to purchase upon such  exercise,  the Company shall
pay the cash value thereof determined as provided in the Warrant Agreement.

        This  Warrant  Certificate  is issued under and in  accordance  with the
Warrant  Agreement and is subject to the terms and provisions  contained in said
Warrant  Agreement,  to all of which terms and provisions the Registered  Holder
consents by acceptance hereof.

        This Warrant  Certificate shall not entitle the Registered Holder to any
of the rights of a shareholder of the Company, including without limitation, the
rights to vote, to receive  dividends and other  distributions,  or to attend or
receive any notice of meetings of shareholders  or any other  proceedings of the
Company.

        This Warrant  Certificate  shall not be valid for any purpose unless and
until it shall have been countersigned by the Warrant Agent.



                               Page 12 of 33 Pages

<PAGE>



        IN WITNESS WHEREOF,  the Company has caused this Warrant  Certificate to
be duly executed under its facsimile Corporate Seal.


Dated: June 21, 1996

                                           EPOCH PHARMACEUTICALS, INC.

                                           ATTEST:


                                                                               
                                           By: /s/ Sanford S. Zweifach
                                               ---------------------------------
                                               Sanford S. Zweifach
                                               President and Corporate Secretary






                               Page 13 of 33 Pages

<PAGE>



                              ELECTION TO PURCHASE


        The undersigned hereby irrevocably elects to  exercise___________ of the
Warrants  represented by this Warrant  Certificate and to purchase the shares of
Common Stock  issuable  upon the exercise of said  Warrants,  and requests  that
certificates for such shares be issued and delivered as follows:


ISSUE TO:

- --------------------------------------------------------------------------------
                                     (NAME)


- --------------------------------------------------------------------------------
                          (ADDRESS, INCLUDING ZIP CODE)


- --------------------------------------------------------------------------------
                (SOCIAL SECURITY OR OTHER TAX IDENTIFYING NUMBER)


DELIVER TO:


- --------------------------------------------------------------------------------
                                     (NAME)


- --------------------------------------------------------------------------------
                          (ADDRESS, INCLUDING ZIP CODE)


        If the number of Warrants hereby exercised is less than all the Warrants
represented by this Warrant  Certificate,  the  undersigned  requests that a new
Warrant  Certificate  representing  the number of full Warrants not exercised be
issued and delivered as set forth below.

        In full  payment  of the  purchase  price with  respect to the  Warrants
exercised and transfer taxes, if any, the undersigned  hereby tenders payment of
$_______  by  certified  check or money order  payable to Warrant  Agent for the
account of the Company in United States currency.

Dated:____________

                                              __________________________________
                                              Insert Social Security or other
                                              identifying number(s) of holder(s)

______________________________________        __________________________________
Name of registered holder - please print      Signature of registered holder


______________________________________        __________________________________
Name of registered holder, if co-owned        Signature of registered holder,
- - please print                                if co-owned


NOTE:   Signature(s)  must  conform  in  all  respects  to  name  of  Registered
        Holder(s) as specified on the face of the Warrant Certificate


                               Page 14 of 33 Pages


<PAGE>



                                   ASSIGNMENT


        FOR VALUE RECEIVED,  the undersigned hereby sells, assigns and transfers
unto the Assignee named below all of the rights of the  undersigned  represented
by the within Warrant Certificate, with respect to the number of warrants as set
forth below:


Name of Assignee                   Address                       No. of Warrants

- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------
- --------------------------------------------------------------------------------

and does hereby irrevocably constitute and  appoint_________________________  to
make such transfer on the books of Epoch  Pharmaceuticals,  Inc.  maintained for
that purpose, with full power of substitution in the premises.


Dated:____________

                                              __________________________________
                                              Insert Social Security or other
                                              identifying number(s) of holder(s)

______________________________________        __________________________________
Name of registered holder - please print      Signature of registered holder


______________________________________        __________________________________
Name of registered holder, if co-owned        Signature of registered holder,
                                              if co-owned - please print


NOTE:   Signature(s)  must  conform  in  all  respects  to  name  of  Registered
        Holder(s) as specified on the face of the Warrant Certificate


Signature(s) Guaranteed:





                              Page 15 of 33 Pages




                                                                       EXHIBIT 3







- --------------------------------------------------------------------------------


                                WARRANT AGREEMENT

                                     BETWEEN

                           EPOCH PHARMACEUTICALS, INC.

                                       AND

                     AMERICAN STOCK TRANSFER & TRUST COMPANY

                            Dated as of June 21, 1996


- --------------------------------------------------------------------------------





                               Page 16 of 33 Pages


<PAGE>



                                TABLE OF CONTENTS

                                                                            Page
                                                                            ----

ARTICLE I
DISTRIBUTION OF WARRANT CERTIFICATES.......................................... 1
         1.1  Appointment of Warrant Agent.................................... 1
         1.2  Form of Warrant Certificates.................................... 1
         1.3  Execution of Warrant............................................ 2
         1.4  Issuance and Distribution of Warrant Certificate................ 2

ARTICLE II
WARRANT EXERCISE PRICE AND EXERCISE OF WARRANTS............................... 2
         2.1  Exercise Price ................................................. 2
         2.2  Registration of Common Stock and Exercisability of Warrants..... 2
         2.3  Procedure for Exercise of Warrants.............................. 3
         2.4  Issuance of Warrant Shares...................................... 3
         2.5  Certificates for Unexercised Warrants........................... 3
         2.6  Reservation of Shares........................................... 3
         2.7  Disposition of Proceeds......................................... 3

ARTICLE III
CALL OF WARRANTS.............................................................. 4
         3.1  Call price and Trigger Price.................................... 4
         3.2  Payment of Call Price........................................... 4

ARTICLE IV
ADJUSTMENTS AND NOTICE PROVISIONS............................................. 4
         4.1  Adjustment of Exercise Price.................................... 4
         4.2  Current Market Price............................................ 5
         4.3  No Adjustment to Exercise Price................................. 5
         4.4  Deferral of Adjustments to Exercise Price....................... 6
         4.5  Adjustment of Number of Shares.................................. 6
         4.6  Reorganization ................................................. 6
         4.7  Reclassification................................................ 6
         4.8  Adjustment of Call Trigger Price................................ 7
         4.9  Verification of Computations.................................... 7
         4.10  Notice of Certain Actions...................................... 7
         4.11  Notice of Call................................................. 8
         4.12  Notice of Adjustments.......................................... 8
         4.13  Warrant Certificate Amendment.................................. 9
         4.14  Fractional Shares.............................................. 9

ARTICLE V
OTHER PROVISIONS RELATING TO RIGHTS OF REGISTERED HOLDERS
OF WARRANT CERTIFICATES....................................................... 9
         5.1  Rights of Warrant Holders....................................... 9
         5.2  Lost, Stolen, Mutilated or Destroyed Warrant Certificates....... 9


                               Page 17 of 33 Pages

<PAGE>


                                                                            Page
                                                                            ----

ARTICLE VI
SPLIT UP, COMBINATION, EXCHANGE, TRANSFER AND CANCELLATION OF
WARRANT CERTIFICATES .........................................................10
         6.1  Split Up, Combination, Exchange and Transfer of 
                Warrant Certificates..........................................10
         6.2  Cancellation of Warrant Certificates............................11
         6.3  Agreement of Warrant Certificate Holders........................11

ARTICLE VII
PROVISIONS CONCERNING THE WARRANT AGENT AND OTHER MATTERS.....................11
         7.1  Payment of Taxes and Charges....................................11
         7.2  Resignation or Removal of Warrant Agent.........................11
         7.3  Notice of Appointment...........................................12
         7.4  Merger of Warrant Agent.........................................12
         7.5  Company Responsibilities........................................12
         7.6  Certification for the Benefit of Warrant Agent..................12
         7.7  Books and Records...............................................12
         7.8  Liability of Warrant Agent......................................13
         7.9  Use of Attorneys, Agents and Employees..........................13
         7.10  Indemnification................................................13
         7.11  Acceptance of Agency...........................................13
         7.12  Changes to Agreement...........................................13
         7.13  Assignment    .................................................14
         7.14  Successor to Company...........................................14
         7.15  Notices       .................................................14
         7.16  Defects in Notice..............................................15
         7.17  Governing Law .................................................15
         7.18  Standing      .................................................15
         7.19  Headings      .................................................15
         7.20  Counterparts  .................................................15
         7.21  Conflict of Interest...........................................15
         7.22  Availability of the Agreement..................................15




                               Page 18 of 33 Pages



<PAGE>



                                WARRANT AGREEMENT

        WARRANT   AGREEMENT   dated  as  of  June  21,   1996,   between   EPOCH
PHARMACEUTICALS,  INC., a Delaware  corporation  (the  "Company"),  and AMERICAN
STOCK TRANSFER & TRUST COMPANY,  a corporation  organized under the banking laws
of the State of New York (the "Warrant Agent").


                              W I T N E S S E T H:


        WHEREAS, the Company has made a private placement of units consisting of
one (1) share of the  Company's  Common  Stock,  par value  $.01 per share  (the
"Common Stock"),  and one (1) Class C Redeemable  Common Stock Purchase Warrants
(the "Warrants") to purchase one-half (1/2) share of the Company's Common Stock;
and

        WHEREAS,  the Company  desires the Warrant Agent,  and the Warrant Agent
agrees,  to act on  behalf  of the  Company  in  connection  with the  issuance,
transfer,  exchange,  replacement,  redemption  and  surrender  of  certificates
representing the Warrants (the "Warrant Certificates"); and

        WHEREAS,  the Company and the Warrant  Agent desire to set forth in this
Warrant  Agreement,  among other things,  the form and provisions of the Warrant
Certificates  and the terms  and  conditions  under  which  they may be  issued,
transferred,  exchanged,  replaced,  redeemed and surrendered in connection with
the exercise and redemption of the Warrants;

        NOW,  THEREFORE,  in  consideration  of the  premises  and of the mutual
agreements herein contained, the parties hereto agree as follows:


                                    ARTICLE I

                      DISTRIBUTION OF WARRANT CERTIFICATES

        1.1  Appointment  of Warrant  Agent.  The Company  hereby  appoints  the
Warrant  Agent  to  act  on  behalf  of  the  Company  in  accordance  with  the
instructions  hereinafter  set forth in this  Agreement,  and the Warrant  Agent
hereby accepts such appointment.

        1.2 Form of Warrant  Certificates.  The  Warrant  Certificates  shall be
issued in registered  form only and,  together with the purchase and  assignment
forms to be printed on the reverse  thereof,  shall be substantially in the form
of Exhibit A attached hereto, and, in addition,  may have such letters,  numbers
or other marks of identification  or designation and such legends,  summaries or
endorsements stamped,  printed,  lithographed or engraved thereon as the Company
may deem  appropriate  and as are not  inconsistent  with the provisions of this
Agreement or as, in any  particular  case,  may be  required,  in the opinion of
counsel for the Company,  to comply with any law or with any rule or  regulation
of any regulatory authority or agency or to conform to customary usage.


                               Page 19 of 33 Pages



<PAGE>




        1.3 Execution of Warrant.  The Warrant Certificates shall be executed on
behalf of the Company by its Chairman of the Board,  Chief Executive  Officer or
President or any Vice President, and by its Chief Financial Officer or Treasurer
or any  Assistant  Treasurer,  or Secretary or any Assistant  Secretary,  either
manually or by facsimile  signature  printed  thereon.  The Warrant  Certificate
shall be manually  countersigned and dated the date of the  countersignature  by
the Warrant Agent and shall not be valid for any purpose unless so countersigned
and dated.  In case any authorized  officer of the Company who shall have signed
any of the Warrant  Certificates  shall cease to be such  officer of the Company
either before or after delivery thereof by the Company to the Warrant Agent, the
signature of such person on such Warrant  Certificates,  nevertheless,  shall be
valid and such Warrant  Certificates  may be  countersigned by the Warrant Agent
and issued and  delivered  to those  persons  entitled to receive  the  Warrants
represented  thereby  with the same  force and  effect as though  the person who
signed  such  Warrant  Certificates  had not  ceased to be such  officer  of the
Company.

        1.4 Issuance and Distribution of Warrant Certificates. The Company shall
deliver to the Warrant Agent an adequate supply of Warrant Certificates executed
on behalf of the Company, as described in Section 1.3 hereof. Upon receipt of an
order from the  Company,  the Warrant  Agent shall within  three  business  days
complete and  countersign  Warrant  Certificates  and shall deliver such Warrant
Certificates pursuant to written instructions of the Company.


                                   ARTICLE II

                 WARRANT EXERCISE PRICE AND EXERCISE OF WARRANTS

        2.1 Exercise  Price.  Each Warrant  Certificate  for the Warrants shall,
when signed by the Chairman,  Chief  Executive  Officer or President or any Vice
President,  and by the Chief  Financial  Officer or Treasurer  or any  Assistant
Treasurer,  or  Secretary  or  any  Assistant  Secretary,  of  the  Company  and
countersigned  by the Warrant  Agent,  entitle the  registered  holder  thereof,
subject to the  provisions  of Article III hereof,  to purchase from the Company
one-half (1/2) share of Common Stock for each Warrant evidenced thereby,  at the
purchase price of $1.25 per one-half (1/2) share (the "Initial Price"),  or such
adjusted number of shares at such adjusted  purchase price as may be established
from time to time pursuant to the  provisions  of Article IV hereof,  payable in
full at the time of exercise  of the  Warrant.  Except as the context  otherwise
requires,  the term "Exercise  Price" as used in this  Agreement  shall mean the
purchase  price of one share of Common  Stock  upon the  exercise  of a Warrant,
reflecting all appropriate adjustments made in accordance with the provisions of
Article IV hereof and Section 7.12 hereof.

        2.2 Registration of Common Stock and  Exercisability  of Warrants.  Each
Warrant may be  exercised  at any time,  but not after 5:00 P.M.,  New York City
time, on the earlier of June 20, 2001 or the business day immediately  preceding
the Call Date (as defined in Section 4.9). The term "Exercise  Deadline" as used
in this Agreement  shall mean the latest time and date at which the Warrants may
be exercised.  Pursuant to the Subscription  Agreements under which the Warrants
were sold,  the  Company is  obligated  to  register  the shares  issuable  upon
exercise of the Warrants.


                               Page 20 of 33 Pages


<PAGE>




        2.3 Procedure for Exercise of Warrants.  During the period  specified in
and  subject to the  provisions  of Section  2.2  hereof,  the  Warrants  may be
exercised by surrendering the Warrant Certificates representing such Warrants to
the Warrant Agent at its principal  office (the  "Principal  Office"),  which is
presently located at 40 Wall Street, New York, New York 10005, with the election
to  purchase  form set  forth on the  Warrant  Certificate  duly  completed  and
executed,  with signatures  guaranteed by a member firm of a national securities
exchange,  a commercial  bank or trust company  located in the United States,  a
member of the National Association of Securities Dealers, Inc. ("NASD") or other
eligible guarantor  institution which is a participant in a signature  guarantee
program  (as such terms are  defined in Reg.  240.17Ad-15  under the  Securities
Exchange Act of 1934, as amended)  acceptable to the Warrant Agent  ("Signatures
Guaranteed"),  accompanied  by payment in full of the Exercise Price as provided
in Section 2.1 in effect at the time of such exercise,  together with such taxes
as are  specified  in Section  7.1 hereof,  for each share of Common  Stock with
respect to which such  Warrants are being  exercised.  Such  Exercise  Price and
taxes shall be paid in full by certified check or money order, payable in United
States currency,  to the Warrant Agent for the account of the Company.  The date
on which  Warrants are  exercised  in  accordance  with this  Section  2.3(a) is
sometimes referred to herein as the Date of Exercise of such Warrants.

        2.4 Issuance of Warrant Shares. As soon as practicable after the Date of
Exercise of any Warrants,  the Company shall issue,  or cause the transfer agent
for the Common Stock,  if any, to issue a certificate  or  certificates  for the
number  of full  shares  of Comon  Stock  to  which  such  holder  is  entitled,
registered  in  accordance  with the  instructions  set forth in the election to
purchase.  All Warrant Shares shall be validly authorized and issued, fully paid
and  nonassessable  and free from all taxes,  liens and  charges  created by the
Company  in  respect  of the issue  thereof,  and shall be  previously  unissued
shares.  Each person in whose name any such  certificate  for Warrant  Shares is
issued  shall for all  purposes be deemed to have become the holder of record of
the Warrant Shares  represented  thereby on the Date of Exercise of the Warrants
resulting in the issuance of such shares,  irrespective  of the date of issuance
or delivery of such certificate for the Warrant Shares.

        2.5 Certificates for Unexercised  Warrants.  In the event that less than
all of the Warrants  represented by a Warrant  Certificate  are  exercised,  the
Warrant Agent shall execute and mail, by first-class mail, within 30 days of the
Date of Exercise, to the registered holder of such Warrant Certificate,  or such
other person as shall be designated  in the election to purchase,  a new Warrant
Certificate  representing the number of full Warrants not exercised. In no event
shall a  fraction  of a  Warrant  be  exercised,  and the  Warrant  Agent  shall
distribute no Warrant Certificates representing fractions of Warrants under this
or any other  section of this  Agreement.  Final  fractions  of shares  shall be
treated as provided in Section 4.14.

        2.6  Reservation  of Shares.  The Company shall at all times reserve and
keep  available  for  issuance  upon the  exercise  of  Warrants a number of its
authorized but unissued shares of Common Stock that will be sufficient to permit
the exercise in full of all outstanding Warrants.

        2.7  Disposition  of Proceeds.  The Warrant Agent shall account at least
monthly (or more frequently upon the request of the Company, provided that in no
event  shall the  Warrant  Agent be required  to account  more  frequently  than
weekly) to the Company  with  respect to  Warrants  exercised  and  concurrently
deliver to the Company all funds.


                               Page 21 of 33 Pages



<PAGE>



                                   ARTICLE III

                                CALL OF WARRANTS

        3.1 Call price and Trigger Price.  The Company may, at its option,  upon
not less than 30 days' nor more than 60 days' notice, call for redemption of all
or any  portion  of the then  outstanding  Warrants  at a call price of $.05 per
warrant (such price is hereinafter referred to as the "Call Price"), at any time
after 9:30 A.M., New York City time, on December 20, 1997,  provided the Current
Market Price of the Company's  Common Stock,  as determined  pursuant to Section
4.2,  has  been at  least  150% of the  then  effective  Exercise  Price  of the
Warrants, as adjusted pursuant to Section 4.8 (the "Call Trigger Price") but not
giving  effect to any  decrease of such  Exercise  Price as permitted by Section
7.12 hereof, for 20 consecutive  business days ending within 15 days of the date
of the notice of such call shall  have been  given to the  Warrant  Agent by the
Company  pursuant to Section  4.11,  and  provided  further that the Company has
compiled and  continues to be in compliance  with the  provisions of Section 2.2
hereof.  In the event the Company  exercises  its right to redeem the  Warrants,
such Warrants will be exercisable  until the close of business on the date fixed
for  redemption  in such notice.  If any Warrant  called for  redemption  is not
exercised  by such time,  such  Warrant  shall cease to be  exercisable  and the
holder thereof shall be entitled only to the redemption price.

        3.2 Payment of Call Price. On or prior to the opening of business on the
Call Date (as  defined in Section  4.11),  the  Company  will  deposit  with the
Warrant  Agent funds in form  satisfactory  to the Warrant  Agent  sufficient to
purchase all the Warrants which are to be called. Payment of the Call Price will
be made by the Warrant  Agent upon  presentation  and  surrender  of the Warrant
Certificates  representing  such Warrant to the Warrant  Agent at its  Principal
Office.


                                   ARTICLE IV

                        ADJUSTMENTS AND NOTICE PROVISIONS

        4.1 Adjustment of Exercise Price.  Subject to provisions of this Article
IV,  the  Exercise  Price  in  effect  from  time to time  shall be  subject  to
adjustment, as follows:

        (a) In case the  Company  shall at any time  after the date  hereof  (i)
declare a dividend  on the  outstanding  Common  Stock  payable in shares of its
capital stock,  (ii) subdivide the outstanding  Common Stock,  (iii) combine the
outstanding  Common  Stock into a smaller  number of  shares,  or (iv) issue any
shares of its capital stock by  reclassification  of the Common Stock (including
any such  reclassification in connection with a consolidation or merger in which
the Company is the  continuing  corporation),  then, in each case,  the Exercise
Price in effect, and the number of shares of Common Stock issuable upon exercise
of the Warrants outstanding, at the time of the record date for such dividend or
of the effective  date of such  subdivision,  combination  or  reclassification,
shall be proportionately adjusted so that the holders of the Warrants after such
time shall be entitled to receive the aggregate number and kind of shares which,
if such Warrants had been exercised immediately prior to such time, such holders
would have owned upon such  exercise  and been  entitled to receive by virtue of
such dividend,  subdivision,  combination or  reclassification.  Such adjustment
shall be made successively whenever any event listed above shall occur.


                               Page 22 of 33 Pages



<PAGE>



        (b) In case the Company shall  distribute to all holders of Common Stock
(including  any such  distribution  made to the  shareholders  of the Company in
connection with a consolidation or merger in which the Company is the continuing
corporation)  evidences  of  its  indebtedness,   cash  or  assets  (other  than
distributions  and  dividends  payable  in shares of Common  Stock),  or rights,
options or warrants to subscribe  for or purchase  Common  Stock,  or securities
convertible into or exchangeable for shares of Common Stock, then, in each case,
the Exercise Price shall be adjusted by multiplying the Exercise Price in effect
immediately  prior to the  record  date for the  determination  of  shareholders
entitled to receive  such  distribution  by a fraction,  the  numerator of which
shall be the Current Market Price (as determined pursuant to Section 4.2 hereof)
per share of Comon Stock on such  record  date,  less the fair market  value (as
determined  in good  faith  by the  board of  directors  of the  Company,  whose
determination  shall be conclusive  absent manifest error) of the portion of the
evidences of  indebtedness  or assets so to be  distributed,  or of such rights,
options, or warrants or convertible or exchangeable securities, or the amount of
such cash,  applicable to one share,  and the denominator of which shall be such
Current  Market Price per share of Common Stock.  Such  adjustment  shall become
effective at the close of business on such record date.

        4.2  Current  Market  Price.  For the purpose of any  computation  under
Section 3.1 and this  Article IV, the  Current  Market  Price per share of Comon
Stock on any date shall be deemed to be the average of the daily closing  prices
for the 20 consecutive trading days immediately  preceding the date in question.
For the purpose of any  computation  hereunder or under Section 3.1, the closing
price for each day shall be the last  reported  sales  price  regular way or, in
case no such  reported  sale  takes  place on such day,  the  closing  bid price
regular  way,  in either  case on the  principal  national  securities  exchange
(including, for purposes hereof, the NASDAQ National Market System) on which the
Common  Stock is listed or admitted  to trading  or, if the Common  Stock is not
listed or admitted to trading on any national securities  exchange,  the highest
reported bid price for the Common Stock as furnished by the NASD through  NASDAQ
or a similar organization if NASDAQ is no longer reporting such information.  If
on any such date the Common  Stock is not listed or  admitted  to trading on any
national  securities  exchange  and is  not  quoted  by  NASDAQ  or any  similar
organization,  the  fair  value  of a share  of  Common  Stock  on such  date as
determined  in good  faith  by the  board of  directors  of the  Company,  whose
determination shall be conclusive absent manifest error, shall be used.

        4.3 No Adjustment to Exercise Price. No adjustment in the Exercise shall
be required if such adjustment is less than $.05;  provided,  however,  that any
adjustments  which by reason of this Article IV are no required to be made shall
be carried  forward and taken into  account in any  subsequent  adjustment.  All
calculations  under this  Article IV shall be made to the nearest cent or to the
nearest one hundredth of a share, as the case may be.

        4.4 Deferral of Adjustments to Exercise Price. In any case in which this
Article  IV shall  require  that an  adjustment  in the  Exercise  Price be made
effective  as of a record date for a specified  event,  the Company may elect to
defer,  until the  occurrence  of such  event,  issuing  to the  holders  of the
Warrants,  if any holder has  exercised a Warrant  after such record  date,  the
shares of Common Stock,  if any,  issuable upon such exercise over and above the
shares of Common Stock, if any,  issuable upon such exercise on the basis of the
Exercise Price in effect prior to such adjustment;  provided,  however, that the
Company shall deliver to such exercising  holder a due bill or other appropriate
instrument evidencing such holder's right to receive such additional shares upon
the occurrence of the event requiring such adjustment.


                               Page 23 of 33 Pages



<PAGE>



        4.5 Adjustment of Number of Shares. Upon each adjustment of the Exercise
Price as a result of the calculation made in Section 4.1(b) hereof, the Warrants
shall thereafter evidence the right to purchase, at the adjusted Exercise Price,
that number of shares (calculated to the nearest hundredth) obtained by dividing
(A) the product  obtained by multiplying the number of shares  purchasable  upon
exercise  of the  Warrants  prior to  adjustment  of the number of shares by the
Exercise  Price in effect prior to adjustment  of the Exercise  Price by (B) the
Exercise Price in effect after such adjustment of the Exercise Price.

        4.6 Reorganization. In case of any capital reorganization, other than in
the cases referred to in Section 4.1 hereof,  or the  consolidation or merger of
the  Company  with  or  into  another   corporation  (other  than  a  merger  or
consolidation in which the Company is the continuing  corporation and which does
not result in any  reclassification of the outstanding shares of Common Stock or
the conversion of such  outstanding  shares of Common Stock into shares of other
stock or other  securities  or property),  or in the case of any sale,  lease or
conveyance  to another  corporation  of the property and assets of any nature of
the Company as an entirety or  substantially  as an entirety (such actions being
hereinafter   collectively  referred  to  as  "Reorganizations"),   there  shall
thereafter be deliverable upon exercise of any Warrant (in lieu of the number of
shares of Common Stock theretofore deliverable) the number of shares of stock or
other securities or property to which a holder of the number of shares of Common
Stock which would  otherwise  have been  deliverable  upon the  exercise of such
Warrant would have been entitled  upon such  Reorganization  if such Warrant had
been exercised in full immediately prior to such Reorganization.  In case of any
Reorganization, appropriate adjustment, as determined in good faith by the Board
of Directors of the Company,  shall be made in the application of the provisions
herein set forth with respect to the rights and interests of Warrant  holders so
that the provisions set forth herein shall  thereafter be applicable,  as nearly
as possible, in relation to any shares or other property thereafter  deliverable
upon exercise of Warrants. Any such adjustment shall be made by and set forth in
a supplemental  agreement between the Company, or any successor thereto, and the
Warrant Agent and shall for all purposes hereof  conclusively be deemed to be an
appropriate  adjustment.  The Company  shall not effect any such  Reorganization
unless upon or prior to the consummation thereof the successor  corporation,  or
if the Company shall be the surviving corporation in any such Reorganization and
is not the issuer of the shares of stock or other  securities  or property to be
delivered to holders of shares of the Common Stock  outstanding at the effective
time thereof, then such issuer shall assume by written instrument the obligation
to deliver to the registered  holder of any Warrant  Certificate  such shares of
stock,  securities,  cash or other  property as such holder shall be entitled to
purchase in  accordance  with the  foregoing  provisions.  In the event of sale,
lease or conveyance or other transfer of all or substantially  all of the assets
of the Company as part of a plan for  liquidation of the Company,  all rights to
exercise any Warrant  shall  terminate 30 days after the Company  gives  written
notice to each  registered  holder of a  Warrant  Certificate  that such sale or
conveyance or other transfer has been consummated.

        4.7  Reclassification.  In case of any reclassification or change of the
shares of Common Stock  issuable  upon  exercise of the  Warrants  (other than a
change in par  value or from no par  value to a  specified  par  value,  or as a
result of a subdivision or  combination,  but including any change in the shares
into two or more classes or series of shares),  or in case of any  consolidation
or merger of another  corporation  into the  Company in which the Company is the
continuing  corporation  and in which  there  is a  reclassification  or  change
(including  a change  to the right to  receive  cash or other  property)  of the
shares of Comon Stock (other than a change in par value, or from no par value to
a

                               Page 24 of 33 Pages



<PAGE>



specified  par  value,  or as a result  of a  subdivision  or  combination,  but
including  any  change  in the  shares  into two or more  classes  or  series of
shares),  the holders of the Warrants shall have the right thereafter to receive
upon exercise of the Warrants  solely the kind and amount of shares of stock and
other securities,  property,  cash, or any combination  thereof  receivable upon
such reclassification, change, consolidation or merger by a holder of the number
of shares of Common  Stock for  which the  Warrants  might  have been  exercised
immediately  prior to such  reclassification,  change,  consolidation or merger.
Thereafter,  appropriate  provision shall be made for adjustments which shall be
as nearly  equivalent as practicable to the adjustments in Article IV. The above
provisions   of  this   Section  4.7  shall   similarly   apply  to   successive
reclassifications and changes of shares of Common Stock.

        4.8  Adjustment  of Call  Trigger  Price.  Upon each  adjustment  of the
Exercise Price of the Warrants  pursuant to Article IV hereof,  the Call Trigger
Price  shall be adjusted by  multiplying  such price as in effect  prior to such
adjustment  by a fraction,  the  numerator of which shall be the Exercise  Price
subsequent  to  adjustment  and the  denominator  of which shall be the Exercise
Price prior to such adjustment. All calculations under this Section 4.8 shall be
made to the nearest cent.

        4.9  Verification  of  Computations.  Whenever  the  exercise  price  is
adjusted as provided in this  Article  IV, the Company  will  promptly  obtain a
certificate of its Chief  Financial  Officer setting forth the exercise price as
so adjusted and a brief statement of the facts  accounting for such  adjustment,
and will make  available a brief  summary  thereof to the holders of the Warrant
Certificates,  at their  addresses  listed on the register  maintained  for that
purpose by the  Warrant  Agent  (which  summary may be included in any notice of
adjustment required by Section 4.12 hereof).

        4.10 Notice of Certain  Actions.  In case at any time the Company  shall
propose:

                (a) to pay any  dividend or make any  distribution  on shares of
        Common  Stock in shares of Common  Stock or make any other  distribution
        (other  than  regularly  scheduled  cash  dividends  which  are not in a
        greater amount per share than the most recent such cash dividend) to all
        holders of Common Stock; or

                (b) to issue any  rights,  warrants or other  securities  to all
        holders of Common Stock entitling them to purchase any additional shares
        of Common Stock or any other rights, warrants or other securities; or

                (c)  to  effect  any  consolidation,  merger,  sale,  lease,  or
        conveyance   of   property,   described   in   Section   4.6,   or   any
        reclassification  or change  of  outstanding  shares  of  Common  Stock,
        described in Section 4.7; or

                (d) to effect any liquidation,  dissolution or winding-up of the
        Company; or

                (e) to take any other action which would cause an  adjustment to
        the Exercise Price;

then, in each such case, the Company shall cause notice of such proposed  action
to be mailed to the Warrant  Agent.  Such notice shall specify the date on which
the books of the Company shall close,


                               Page 25 of 33 Pages



<PAGE>



or a record shall be taken, for determining  holders of Common Stock entitled to
receive such stock dividend or other distribution or such rights or warrants, or
the date on which such reclassification,  change,  consolidation,  merger, sale,
lease, other disposition,  liquidation,  dissolution,  winding up or exchange or
other action  shall take place of commence,  as the case may be, and the date as
of which it is expected  that holders of record of Comon Stock shall be entitled
to receive  securities or other property  deliverable  upon such action,  if any
such date has been fixed.  The Company  shall cause  copies of such notice to be
mailed to each registered holder of a Warrant Certificate.  Such notice shall be
mailed,  in the case of any  action  covered  by  Subsection  4.10(a) or 4.10(b)
above, at least 15 days prior to the record date for determining  holders of the
Comon Stock for purposes of receiving such payment or offer;  in the case of any
action covered by Subsection 4.10(c) or 4.10(d) above, at least 15 days prior to
the  earlier of the date upon  which such  action is to take place or any record
date to determine  holders of Comon Stock entitled to receive such securities or
other  property;  and in the case of any action  covered by  Subsection  4.10(e)
above, no more than 15 days after such action.

        4.11 Notice of Call. Notice of any call for redemption shall be given to
the  Warrant  Agent by the  Company  upon not less than 30 days nor more than 60
days  prior to the date  established  for such call (the  "Call  Date")  and the
Company  shall  cause the Warrant  Agent to mail such  notice to all  registered
holders of Warrant  Certificates  to be called  promptly after the Company shall
have given  such  notice to the  Warrant  Agent.  Each such  notice of call will
specify the Call Date and the Call Price.  The notice will state that payment of
the Call Price will be made by the Warrant Agent upon presentation and surrender
of the Warrant  Certificates  representing such Warrants to the Warrant Agent at
its  Principal  Office,  and will  also  state  that the right to  exercise  the
Warrants  will  terminate at 5:00 P.M.,  New York City time, on the business day
immediately  preceding  the Call Date.  The Company will also make prompt public
announcement of such redemption by news release and by notice to the NASD or any
national securities exchange on which the Warrants are listed for trading.

        4.12 Notice of Adjustments.  Whenever any adjustment is made pursuant to
this Article IV, the Company shall cause written notice of such adjustment to be
sent by  registered  mail,  postage  prepaid to the Warrant Agent within 15 days
thereafter,  such  notice  to  include  in  reasonable  detail  (i)  the  events
precipitating the adjustment, (ii) the computation of any adjustments, and (iii)
the Exercise  Price,  the number of shares or the  securities or other  property
purchasable  upon  exercise  of each  Warrant and the Call  Trigger  price after
giving effect to such  adjustment.  The Company  shall cause the Warrant  Agent,
within 15 days after receipt for such notice from the Company, to mail a similar
notice to be mailed to each registered holder of a Warrant Certificate.

        4.13 Warrant  Certificate  Amendment.  Irrespective  of any  adjustments
pursuant to this Article IV,  Warrant  Certificates  theretofore  or  thereafter
issued need not be amended or replaced but certificates  thereafter issued shall
bear an appropriate legend or other notice of any adjustments.

        4.14  Fractional  Shares.  The Company  shall not be  required  upon the
exercise of any  Warrant to issue  fractional  shares of Common  Stock which may
result from such exercise.  If more than one Warrant is exercised at one time by
the same  registered  holder,  the number of full  shares of Common  Stock which
shall be deliverable shall be computed based on the number of shares deliverable
in exchange for the aggregate number of Warrants exercised.  With respect to any
final

                               Page 26 of 33 Pages



<PAGE>



fraction of a share called for upon the exercise of any Warrant or Warrants, the
Company may pay a cash adjustment in respect of such final fraction in an amount
equal to the same fraction of the Current Market Price of a share of Comon Stock
calculated in accordance with section 4.2.


                                    ARTICLE V

                          OTHER PROVISIONS RELATING TO
                          RIGHTS OF REGISTERED HOLDERS
                             OF WARRANT CERTIFICATES

        5.1 Rights of Warrant Holders.  No Warrant Certificate shall entitle the
registered  holder thereof to any of the rights of a shareholder of the Company,
including, without limitation, the right to vote, to receive dividends and other
distributions,  or  to  receive  any  notice  of,  or  to  attend,  meetings  of
shareholders or any other proceedings of the Company.

        5.2 Lost, Stolen,  Mutilated or Destroyed Warrant  Certificates.  If any
Warrant Certificates shall be mutilated,  lost, stolen or destroyed, the Company
shall  direct  the  Warrant  Agent to  execute  and  deliver,  in  exchange  and
substitution for and upon cancellation of a mutilated Warrant Certificate, or in
lieu of or in substitution for a lost, stolen or destroyed Warrant  Certificate,
a new Warrant Certificate for the number of Warrants  represented by the Warrant
Certificate  so  mutilated,  lost,  stolen or destroyed but only upon receipt of
evidence of such loss, theft or destruction of such Warrant Certificate,  and of
the ownership  thereof,  and indemnity,  if requested,  all  satisfactory to the
Company  and  the  Warrant  Agent.   Applicants  for  such  substitute   Warrant
Certificates  shall also comply with such other  reasonable  regulations and pay
such other reasonable  charges incidental hereto as the Company or Warrant Agent
may prescribe.  Any such new Warrant  Certificate  shall  constitute an original
contractual  obligation  of the  Company,  whether  or not the  allegedly  lost,
stolen,  mutilated  or  destroyed  Warrant  Certificate  shall  be at  any  time
enforceable by anyone.


                                   ARTICLE VI

                    SPLIT UP, COMBINATION, EXCHANGE, TRANSFER
                    AND CANCELLATION OF WARRANT CERTIFICATES

        6.1  Split  Up,   Combination,   Exchange   and   Transfer   of  Warrant
Certificates.  Prior to the Exercise Deadline, Warrant Certificates,  subject to
the provisions of Section 6.2, may be split up,  combined or exchanged for other
Warrant Certificates  representing a like aggregate number of Warrants or may be
transferred  in whole or in part.  Any holder  desiring to split up,  combine or
exchange a Warrant  Certificate or Warrant  Certificates shall make such request
in writing  delivered  to the Warrant  Agent at its  Principal  Office and shall
surrender the Warrant  Certificate  or Warrant  Certificates  so to be split up,
combined or exchanged at said office.  Subject to any applicable  laws, rules or
regulations restricting transferability, any restriction on transferability that
may appear on a Warrant  Certificate in accordance with the terms hereof, or any
"stop-transfer" instructions the

                               Page 27 of 33 Pages



<PAGE>



Company may give to the Warrant Agent to implement any such restrictions  (which
instructions  the  Company  is  expressly  authorized  to  give),   transfer  of
outstanding Warrant  Certificates may be effected by the Warrant Agent from time
to time upon the books of the Company to be  maintained by the Warrant Agent for
that purpose,  upon a surrender of the Warrant  Certificate to the Warrant Agent
at its  Principal  Office,  with the  assignment  form set forth in the  Warrant
Certificate  daily  executed  and  with  Signatures  Guaranteed.  Upon  any such
surrender  for split up,  combination,  exchange or transfer,  the Warrant Agent
shall execute and deliver to the person entitled  thereto a Warrant  Certificate
or Warrant Certificates,  as the case may be, as so requested. The Warrant Agent
may require the holder to pay a sum sufficient to cover any tax or  governmental
charge  that may be  imposed  in  connection  with any  split  up,  combination,
exchange or transfer of Warrant  Certificates  prior to the  issuance of any new
Warrant Certificate.

        6.2  Cancellation  of  Warrant  Certificates.  Any  Warrant  Certificate
surrendered upon the exercise of Warrants or for split up, combination, exchange
or  transfer,  or  purchase  or  otherwise  acquired  by the  Company,  shall be
cancelled and shall not be reissued by the Company;  and, except as provided (i)
in  Section  2.5,  in case of the  exercise  of less  than  all of the  Warrants
evidenced by a Warrant  Certificate,  or (ii) in Section 6.1, in case of a split
up,  combination,  exchange or transfer of the  Warrants  evidenced by a Warrant
Certificate,  no Warrant  Certificate  shall be issued hereunder in lieu of such
cancelled  Warrant  Certificate.  Any Warrant  Certificate so cancelled shall be
destroyed by the Warrant Agent unless otherwise directed by the Company.

        6.3 Agreement of Warrant Certificate Holders.  Every holder of a Warrant
Certificate  by accepting  the same consents and agrees with the Company and the
Warrant Agent and with every other holder of a Warrant Certificate that:

        (a)  transfer of the Warrant  Certificates  shall be  registered  on the
books of the Company  maintained  for that purpose by the Warrant  Agent only if
surrendered  at the  Principal  Office of the Warrant  Agent,  duly  endorsed or
accompanied by a proper instrument of transfer, with Signatures Guaranteed; and

        (b) prior to due presentment for  registration of transfer,  the Company
and the  Warrant  Agent may deem and treat the person in whose name the  Warrant
Certificate  is  registered  as the absolute  owner  thereof and of the Warrants
evidenced thereby  (notwithstanding any notations of ownership or writing on the
Warrant Certificates made by anyone other than the Company or the Warrant Agent)
for all purposes whatsoever, and neither the Company nor the Warrant Agent shall
be affected by any notice to the contrary.


                                   ARTICLE VII

                            PROVISIONS CONCERNING THE
                         WARRANT AGENT AND OTHER MATTERS

        7.1 Payment of Taxes and  Charges.  The  Company  will from time to time
promptly  pay to the  Warrant  Agent,  or make  provisions  satisfactory  to the
Warrant  Agent for the payment of, all taxes and charges  that may be imposed by
the  United  States  or any  state  upon the  Company  or the  Warrant  Agent in
connection  with the  issuance or  delivery  of shares of Common  Stock upon the
exercise of any Warrant,  but any transfer taxes in connection with the issuance
of Warrant  Certificates or certificates  for shares of Common Stock in any name
other than that of the registered

                               Page 28 of 33 Pages



<PAGE>



holder of the Warrant  Certificate  surrendered shall be paid by such registered
holder; and, in such case, the Company shall not be required to issue or deliver
any Warrant  Certificate  or  certificate  for shares of Common Stock until such
taxes  shall  have  been  paid  or it has  been  established  to  the  Company's
satisfaction that no tax is due.

        7.2  Resignation  or Removal of Warrant  Agent.  The  Warrant  Agent may
resign its duties and be  discharged  from all  further  duties and  liabilities
hereunder  after giving 30 days'  notice in writing to the Company,  except that
such shorter  notice may be given as the Company  shall,  in writing,  accept as
sufficient.  Upon comparable notice to the Warrant Agent, the Company may remove
the Warrant  Agent;  provided,  however,  that in such event the  Company  shall
appoint a new Warrant  Agent,  as hereinafter  provided,  and the removal of the
Warrant  Agent  shall  not be  effective  until a new  Warrant  Agent  has  been
appointed  and has accepted  such  appointment.  If the office of Warrant  Agent
becomes  vacant by  resignation  or incapacity to act or otherwise,  the Company
shall appoint in writing a new Warrant Agent.  If the Company shall fail to make
such  appointment  within a period  of 30 days  after  it has been  notified  in
writing of such  resignation  or incapacity  by the  resigning or  incapacitated
Warrant Agent or by the registered holder of any Warrant  Certificate,  then the
registered holder of any Warrant Certificate may apply to any court of competent
jurisdiction for the appointment of a new Warrant Agent.  Any successor  Warrant
Agent, whether appointed by the Company or any such court, shall be a registered
transfer agent,  bank or trust company in good standing and  incorporated  under
the United States  banking laws or under the laws of any state within the United
States,  having its principal  office within the United States.  Any new Warrant
Agent appointed  hereunder shall execute,  acknowledge and deliver to the former
Warrant Agent last in office and to the Company,  an instrument  accepting  such
appointment  under  substantially the same terms and conditions as are contained
herein and thereupon  such new Warrant  Agent,  without any further act or deed,
shall become vested with the rights,  powers, duties and responsibilities of the
Warrant Agent and the former  Warrant Agent shall cease to be the Warrant Agent;
but if for any  reason it  becomes  necessary  or  expedient  to have the former
Warrant  Agent  execute and deliver any further  assurance,  conveyance,  act or
deed,  the same shall be done at the expense of the Company and shall be legally
and validly executed and delivered by the former Warrant Agent.

        7.3  Notice of  Appointment.  Not later than the  effective  date of the
appointment of a new Warrant Agent, the Company shall cause notice thereof to be
mailed to the former  Warrant  Agent and the  transfer  agent,  if any,  for the
Common  Stock and shall  forthwith  cause a copy of such  notice to be mailed to
each registered holder of a Warrant Certificate. Failure to mail such notice, or
any defect  contained  therein,  shall not affect the  legally or validly of the
appointment of the successor Warrant Agent.

        7.4 Merger of Warrant  Agent.  Any company into which the Warrant  Agent
may be merged or with which it may be  consolidated,  or any  company  resulting
from any merger or  consolidation  to which the Warrant  Agent shall be a party,
shall be the successor  Warrant Agent under this Agreement  without further act,
provided  that such  company  would be eligible for  appointment  as a successor
Warrant  Agent under the  provisions of Section 7.2 hereof.  Any such  successor
Warrant Agent may adopt the prior  countersignature  of any predecessor  Warrant
Agent and distribute Warrant  Certificates  countersigned but not distributed by
such predecessor  Warrant Agent, or may countersign the Warrant  Certificates in
its own name.


                               Page 29 of 33 Pages



<PAGE>




        7.5 Company  Responsibilities.  The Company agrees that it shall (i) pay
the Warrant  Agent  reasonable  remuneration  for its services as Warrant  Agent
hereunder  and will  reimburse  the Warrant  Agent upon demand for all expenses,
advances and  expenditures  that the Warrant Agent may  reasonably  incur in the
execution of its duties hereunder  (including fees and expenses of its counsel);
(ii) provide the Warrant Agent,  upon request,  with sufficient funds to pay any
cash due pursuant to Section 4.14 upon exercise of Warrants;  and (iii) perform,
execute,   acknowledge   and  deliver  or  cause  to  be  performed,   executed,
acknowledged  and  delivered  all  further  and  other  acts,   instruments  and
assurances  as may  reasonably be required by the Warrant Agent for the carrying
out or performing by the Warrant Agent of the provisions of this Agreement.

        7.6  Certification  for the  Benefit of Warrant  Agent.  Whenever in the
performance  of its duties under this  Agreement the Warrant Agent shall deem it
necessary  or  desirable  that any matter be proved or  established  or that any
instructions  with respect to the  performances of its duties hereunder be given
by the Company  prior to taking or suffering any action  hereunder,  such matter
(unless other evidence in respect thereof be herein specifically prescribed) may
be deemed to be conclusively proved and established, or such instructions may be
given,  by a  certificate  or  instrument  signed  by the  Chairman,  the  Chief
Executive  Officer,  the  President,  a Vice  President,  the  Secretary  or the
Treasurer of the Company and delivered to the Warrant Agent. Such certificate or
instrument  may be relied  upon by the  Warrant  Agent for any  action  taken or
suffered in good faith by it under the provisions of this Agreement;  but in its
discretion  the Warrant Agent may in lieu thereof  accept other evidence of such
matter or it may  require  such  further or  additional  evidence as it may deem
reasonable.

        7.7 Books and Records.  The Warrant  Agent shall  maintain the Company's
books and records for  registration  and registration of transfer of the Warrant
Certificates  issued hereunder.  Such books and records shall show the names and
addresses of the respective holders of the Warrant  Certificates,  the number of
Warrants evidenced on its face by each Warrant  Certificate and the date of each
Warrant Certificate.

        7.8  Liability  of Warrant  Agent.  The  Warrant  Agent  shall be liable
hereunder for its own negligence or willful misconduct.  The Warrant Agent shall
act  hereunder  solely  as an agent  for the  Company  and its  duties  shall be
determined  solely by the  provisions  hereof.  The  Warrant  Agent shall not be
liable for or by reason of any of the  statements of fact or recitals  contained
in this Agreement or in the Warrant Certificates  (except its  counter-signature
thereof) or be required to verify the same, but all such statements and recitals
are and shall be deemed to have been made by the Company only. The Warrant Agent
will not incur any liability or  responsibility  to the Company or to any holder
of any Warrant  Certificate for any action taken, or any failure to take action,
in reliance on any notice,  resolution,  waiver, consent, order,  certificate or
other paper,  document or instrument reasonably believed by the Warrant Agent to
be genuine and to have been  signed,  sent or  presented  by the proper party or
parties.  The Warrant Agent shall not be under any  responsibility in respect of
the validity of this  Agreement  or the  execution  and  delivery  hereof by the
Company or in respect of the validly or  execution  of any  Warrant  Certificate
(except its  counter-signature  thereof);  nor shall it be  responsible  for any
breach by the Company of any covenant or condition  contained in this  Agreement
or in any Warrant Certificate; nor shall it be responsible for the making of any
adjustment required under the provisions of Article IV hereof or responsible for
the  manner,  method or amount of any such  adjustment  or the facts  that would
require any such adjustment; nor shall it by any act hereunder be deemed to make
any representation or warranty as to the

                               Page 30 of 33 Pages



<PAGE>



authorization  or reservation of any shares of Common Stock or other  securities
to be issued  pursuant to this  Agreement  or any Warrant  Certificate  or as to
whether any shares of Comon Stock or other  securities  will,  when  issued,  be
validly authorized and issued and fully paid and nonassessable.

        7.9 Use of  Attorneys,  Agents  and  Employees.  The  Warrant  Agent may
execute and exercise any of the rights or powers  hereby vested in it or perform
any duty  hereunder  either  itself or by or through  its  attorneys,  agents or
employees.

        7.10 Indemnification.  The Company agrees to indemnify the Warrant Agent
and   save   it   harmless   against   any   and   all   losses,   expenses   or
liabilities,including  judgments,  costs and  counsel  fee  arising out of or in
connection  with its  agency  under  this  Agreement,  except as a result of the
negligence or willful misconduct of the Warrant Agent.

        7.11  Acceptance of Agency.  The Warrant Agent hereby accepts the agency
established  by this Agreement and agrees to perform the same upon the terms and
conditions herein set forth.

        7.12 Changes to Agreement. The Warrant Agent may, without the consent or
concurrence of any registered holder of a Warrant  Certificate,  by supplemental
agreement  or  otherwise,  join  with the  Company  in  making  any  changes  or
corrections  in this  Agreement that they shall have been advised by counsel (i)
are required to cure any ambiguity or to correct any  defective or  inconsistent
provision or clerical  omission or mistake or manifest  error herein  contained;
(ii) add to the covenants and  agreements of the Company or the Warrant Agent in
this Agreement such further covenants and agreements  thereafter to be observed;
or (iii) result in the surrender or  modification of any right or power reserved
to or  conferred  upon  the  Company  or the  Warrant  Agent  in his  Agreement,
including,  without limitation,  the reduction of the Exercise Price (except for
purposes of Article III hereof), but which changes or corrections do not or will
not adversely  affect,  alter or change the rights,  privileges or immunities of
the registered holders of Warrant Certificates.

        7.13  Assignment.  All the covenants and provisions of this Agreement by
or for the benefit of the  Company or the Warrant  Agent shall bind and inure to
the benefit of their respective successors and assigns.

        7.14  Successor to Company.  The Company will not merger or  consolidate
with or into any other  corporation or sell or otherwise  transfer its property,
assets and  business  substantially  as an entirety to a successor  corporation,
unless  the  corporation  resulting  from such  merger,  consolidation,  sale or
transfer (if not the Company) shall expressly assume, by supplemental  agreement
satisfactory  in form and  substance to the Warrant  Agent and  delivered to the
Warrant Agent, the due and punctual performance and observance of each and every
covenant  and  condition of this  Agreement to be performed  and observed by the
Company.

        7.15  Notices.  Any notice or demand  required by this  Agreement  to be
given or made by the Warrant  Agent or by the  registered  holder of any Warrant
Certificate to or on the Company shall be sufficiently  given or made if sent by
first-class  or registered  mail,  postage  prepaid,  addressed  (until  another
address is filed in writing with the Warrant Agent by the Company), as follows:


                               Page 31 of 33 Pages



<PAGE>




                       Epoch Pharmaceuticals, Inc.
                       1725 220th Street, S.E. No. 104
                       Bothel, Washington 98021
                       Attention: Chief Financial Officer

Any  notice  or demand  required  by this  Agreement  to be given or made by the
registered  holder of any  Warrant  Certificate  or by the  Company to or on the
Warrant  Agent shall be  sufficiently  given or made if sent by  first-class  or
registered mail,  postage prepaid,  addressed (until another address is filed in
writing with the Company by the Warrant Agent), as follows:

                       American Stock Transfer & Trust Company
                       40 Wall Street
                       New York, New York  10005
                       Attention:  George Karfunkel

Any  notice  or demand  required  by this  Agreement  to be given or made by the
Company  or the  Warrant  Agent to or on the  registered  holder of any  Warrant
Certificate  shall be  sufficiently  given or made,  whether or not such  holder
receives the notice, if sent by first-class or registered mail, postage prepaid,
addressed to such registered holder at his last address as shown on the books of
the Company  maintained by the Warrant  Agent.  Otherwise  such notice or demand
shall be deemed given when received by the party entitled thereto.

        7.16 Defects in Notice.  Failure to file any certificate or notice or to
mail any notice,  or any defect in any  certificate  or notice  pursuant to this
Agreement  shall not affect in any way the rights or any registered  holder of a
Warrant  Certificate or the legally or validity of any adjustment  made pursuant
to Article IV hereof, or any transaction giving rise to any such adjustment,  or
the legality or validity of any action taken or to be taken by the Company.

        7.17  Governing Law. The laws of the State of New York shall govern this
Warrant Agreement and the Warrant Certificates.

        7.18 Standing.  Nothing in this Agreement expressed and nothing that may
be implied from any of the provisions hereof is intended, or shall be construed,
to confer upon,  or give to, any person or  corporation  other than the Company,
the Warrant Agent,  and the registered  holders of the Warrant  Certificates any
right,  remedy or claim under or by reason of this Agreement or of any covenant,
condition,   stipulation,   promise  or  agreement  contained  herein;  and  all
covenants, conditions,  stipulations,  promises and agreements contained in this
Agreement  shall be for the sole and  exclusive  benefit of the  Company and the
Warrant Agent and their  respective  successors and assigns,  and the registered
holders of the Warrant Certificates.

        7.19 Headings.  The descriptive headings of the articles and sections of
this Agreement are inserted for convenience only and shall not control or affect
the meaning or construction of any of the provisions hereof.

        7.20  Counterparts.  This  Agreement  may be  executed  in any number of
counterparts,  each of which so executed shall be deemed to be an original;  but
such counterparts shall together constitute but one and the same instrument.


                               Page 32 of 33 Pages



<PAGE>


        7.21  Conflict  of  Interest.  The  Warrant  Agent and any  shareholder,
director,  officer or employee of the Warrant Agent may buy, sell or deal in any
of the  Warrant  Certificates  or other  securities  of the  Company  or  become
pecuniarily   interested  in  any  transaction  in  which  the  Company  may  be
interested,  or contract  with or lend money to the Company or otherwise  act as
fully and freely as though the Warrant  Agent were not Warrant  Agent under this
Agreement.  Nothing  herein shall  preclude the Warrant Agent from acting in any
other capacity for the Company, including,  without limitation, as trustee under
any indentures or as transfer agent for the Common Stock or any other securities
of the Company, or for any other legal entity.

        7.22 Availability of the Agreement.  The Warrant Agent shall keep copies
of this Agreement  available for inspection by holders of Warrants during normal
business hours at its Principal Office. Copies of this Agreement may be obtained
upon written request addressed to:

                       Epoch Pharmaceuticals, Inc.
                       1725 220th Street, S.E. No. 104
                       Bothel, Washington  98021
                       Attention:  Chief Financial Officer

        IN WITNESS WHEREOF, this Agreement has been duly executed by the parties
hereto as of the day and year first above written.

                           EPOCH PHARMACEUTICALS, INC.


                           By:      /s/ Stanford Zweifach
                              --------------------------------------------------
                                    Name:  Stanford Zweifach
                                    Title: President and Chief Financial Officer


                           AMERICAN STOCK TRANSFER & TRUST COMPANY


                           By:      /s/ Herbert J. Lemmer
                              --------------------------------------------------
                                    Name:  Herbert J. Lemmer
                                    Title: Vice President


                               Page 33 of 33 Pages





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