EPOCH PHARMACEUTICALS INC
NT 10-K, 1999-03-31
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                                       SEC FILE NUMBER
                                                                                
                                                           0-22170
                                              ----------------------------------
                                                         CUSIP NUMBER
                                                                                
                                                         294273 10 7
                                              ----------------------------------

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                   FORM 12b-25

                           NOTIFICATION OF LATE FILING

(Check One):
[X]  Form 10-KSB [ ] Form 20-F [ ] Form 11-K [ ] Form 10-Q [ ] Form N-SAR 

     For Period Ended: DECEMBER 31, 1998 
     [ ] Transition Report on Form 10-KSB 
     [ ] Transition Report on Form 20-F 
     [ ] Transition Report on Form 11-K 
     [ ] Transition Report on Form 10-Q 
     [ ] Transition Report on Form N-SAR 
     For the Transition Period Ended:
                                      ------------------------------------------

- --------------------------------------------------------------------------------
  Read Instruction (on back page) Before Preparing Form. Please Print or Type.
    NOTHING IN THIS FORM SHALL BE CONSTRUED TO IMPLY THAT THE COMMISSION HAS
                   VERIFIED ANY INFORMATION CONTAINED HEREIN.
- --------------------------------------------------------------------------------

If the notification relates to a portion of the filing checked above, identify
the Item(s) to which the notification relates:

- --------------------------------------------------------------------------------

PART I -- REGISTRANT INFORMATION

EPOCH PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
Full Name of Registrant

MICROPROBE CORPORATION
- --------------------------------------------------------------------------------
Former Name if Applicable

12277 134th Court NE, Suite 100
- --------------------------------------------------------------------------------
Address of Principal Executive Office (Street and Number)

Redmond, WA  98021
- --------------------------------------------------------------------------------
City, State and Zip Code

PART II -- RULES 12b-25(b) AND (c)

If the subject report could not be filed without unreasonable effort or expense
and the registrant seeks relief pursuant to Rule 12b-25(b), the following should
be completed. (Check box if appropriate)

        (a) The reasons described in reasonable detail in Part III of
            this form could not be eliminated without unreasonable effort or
            expense;
        (b) The subject annual report, semi-annual report, transition report on
[X]         Form 10-K, Form 20-K, 11-K, Form N-SAR, or portion thereof, will be
            filed on or before the fifteenth calendar day following the
            prescribed due date; or the subject quarterly report of transition
            report on Form 10-Q, or portion thereof will be filed on or before
            the fifth calendar day following the prescribed due date; and
        (c) The accountant's statement or other exhibit required by Rule
            12b-25(c) has been attached if applicable.

PART III -- NARRATIVE

State below in reasonable detail the reasons why the Form 10-K, 11-K, 10-Q,
N-SAR, or the transition report or portion thereof, could not be filed within
the prescribed time period. (ATTACH EXTRA SHEETS IF NEEDED)

(See attached Summary)                                         SEC 1344 (11-91)


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PART IV -- OTHER INFORMATION

(1) Name and telephone number of person to contact in regard to this
    notification

    Sanford S. Zweifach              425                   821-7535
    -------------------           -----------          ------------------
          (Name)                  (Area Code)          (Telephone Number)

(2) Have all other periodic reports required under Section 13 or 15(d) of the
    Securities Exchange Act of 1934 or Section 30 of the Investment Company Act
    of 1940 during the preceding 12 months (or for such shorter
    period that the registrant was required to file such reports) been filed?
    If the answer is no, identify report(s).              [X] Yes   [ ] No


(3) Is it anticipated that any significant change in results of operations form
    the corresponding period for the last fiscal year will be reflected by the
    earnings statements to be included in the subject report or 
    portion thereof?                                      [ ] Yes   [X] No

    If so, attach an explanation of the anticipate change, both narratively and
    quantitatively, and, if appropriate, state the reasons why a reasonable
    estimate of the results cannot be made.

================================================================================

                           EPOCH PHARMACEUTICALS, INC.
- --------------------------------------------------------------------------------
                  (Name of Registrant as Specified in Charter)

has caused this notification to be signed on its behalf by the undersigned
hereunto duly authorized.

Date March 31, 1999                     By /s/ Sanford S. Zweifach
     ---------------------------           -------------------------------------
                                           Sanford S. Zweifach, President, CFO 
                                           and Secretary

INSTRUCTION: The firm may be signed by an executive officer of the registrant or
by any other duly authorized representative. The name and title of the person
signing the form shall be typed or printed beneath the signature. If the
statement is signed on behalf of the registrant by an authorized representative
(other than an executive officer), evidence of the representative's authority to
sign on behalf of the registrant shall be filed with the form.



- --------------------------------------------------------------------------------
                                    ATTENTION
   INTENTIONAL MISSTATEMENTS OR OMISSIONS OF FACT CONSTITUTE FEDERAL CRIMINAL
                        VIOLATIONS (SEE 18 U.S.C. 1001).
- --------------------------------------------------------------------------------

                              GENERAL INSTRUCTIONS

1.  This form is required by Rule 12b-25 (17 CFR 240.12b-25) of the General
    Rules and Regulations under the Securities Exchange Act of 1934.

2.  One signed original and four conformed copies of this form and amendments
    thereto must be completed and filed with the Securities and Exchange
    Commission, Washington, D.C. 20549, in accordance with Rule 0-3 of the
    General Rules and Regulation sunder the Act. The information contained in or
    filed with the form will be made a matter of public record in the Commission
    Files.

3.  A manually signed copy of the form and amendments thereto shall be filed
    with each national securities exchange on which any class of securities of
    the registrant is registered.

4.  Amendments to the notifications must also be filed on form 12b-25 but need
    not restate information that has been correctly furnished. The form shall be
    clearly identified as an amended notification.




                                       2


<PAGE>   3

FORM 12b-25

EPOCH PHARMACEUTICALS, INC.
    (Supplement)


PART III -- NARRATIVE

    The Annual Report on Form 10-KSB for the year ended December 31, 1998 could
not be filed within the prescribed time period because the Company was unable,
without unreasonable effort or expense, to obtain certain information required
to describe the change in the focus of the Company's business activities.





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