BIONEBRASKA INC
10-12G/A, EX-10.14, 2000-11-13
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                                                                  EXHIBIT 10-14

                             CONFIDENTIAL TREATMENT
CERTAIN INFORMATION HAS BEEN DELETED FROM THIS EXHIBIT AND FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO A REQUEST FOR
CONFIDENTIAL TREATMENT UNDER RULE 24b-2.

                          CAMBRIDGE BIOTECH CORPORATION

                                                                   July 15, 1996


BioNebraska, Inc.
3820 NW 46th Street
Lincoln, Nebraska 68524
Attention: Mr. Thomas R. Coolidge
           Chairman of the Board and C.E.O.


OT Company
Suite #4
11823 Arbor
Omaha, Nebraska 68144


GRF Corporation
3820 NW 46th Street
Lincoln, Nebraska 68524

Dear Tom:


I would like to confirm our settlement agreement among Cambridge Biotech
Corporation ("CBC"), GRF Corporation ("GRFCO"), OT Company ("OTJV") and
BioNebraska, Inc. ("BN") concerning CBC's interest in GRFCO and related matters.

We have agreed on the following terms that BN will acquire all of CBC's interest
in the Joint Venture Agreement, under date of July 23, 1992 (the "Joint Venture
Agreement") and all of CBC's 38 shares of Class A Stock of GRFCO and that
certain agreements of CBC will be cancelled and terminated. Capitalized terms
used herein, unless otherwise stated, shall have the meanings set forth in the
Joint Venture Agreement.

1.   BN shall pay to CBC or its successor or its assign (it is understood and
     agreed that CBC's interest in this settlement agreement, including future
     royalties and other payments, may be assigned to its successor under its
     reorganization plan, Aquila Biopharmaceuticals, Inc.) the sum of $500,000
     at the closing (the "Closing") under this settlement agreement which shall
     occur on or before August 15, 1996. At the Closing, CBC shall deliver to
     BN, duly

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     endorsed, certificates for 38 shares of Class A GRFCO Common Stock and a
     duly executed assignment of all of CBC's interest in the Joint Venture
     Agreement, free and clear of all encumbrances and in such form and with
     such other documentation as may be reasonably required to effectively
     transfer all of such interests to BN. OTJV and BN hereby waive any
     provision of the Joint Venture Agreement including, without limitation,
     those contained in Sections 9.2 and 10.1 thereof which would in any way
     restrict, condition or make void the transfer contemplated by this section.

2.   CBC (or its successor or assign) will be paid (quarterly) for a period of
     twenty years from the date hereof a royalty of [CONFIDENTIAL TREATMENT
     REQUESTED] of net sales of commercial growth hormone releasing factor
     ("GRF") finished product (pursuant to an NDA, PLA or similar application
     form approved by the FDA or equivalent regulatory authority approval) made
     by GRFCO, OTJV (or its joint venture partners) or BN or by any of their
     collaborators or licensees or any other party which is an owner or
     licensee of GRF Technology which has been discovered, developed or
     acquired by GRFCO, BN or OTJV or any of their successors or affiliates.
     For the purposes of this agreement, GRF Technology shall be deemed to
     include all GRF Technology whenever developed and shall, without
     limitation, include GRF Technology developed during the term of the
     Joint Venture Agreement. A GRF finished product may also contain one
     or more other therapeutically active products; and in such an event the
     royalty rate shall be [CONFIDENTIAL TREATMENT REQUESTED] of such net
     sales. In the case where GRF is manufactured in bulk by BN (or its
     contractors) and the full royalty of [CONFIDENTIAL TREATMENT REQUESTED]
     is paid, [CONFIDENTIAL TREATMENT REQUESTED] of the net sales price of
     the GRF finished product will be deducted before the royalty is calculated.
     All royalty payments due hereunder shall be made within 60 days after the
     close of each calendar quarter when earned and each such payment shall be
     accompanied by a report, prepared by BN or GRFCO, setting forth INTER ALIA
     the applicable total sales of GRF finished product for the quarter in
     question, the amount of any "license fee" payable to CBC or its successor
     or assign pursuant to paragraph 3 hereof, the calculation of the royalty
     or license fee being paid at the time and any other information, directly
     pertinent to the determination of the royalty or license fee, as may be
     reasonably requested by the recipient. The recipient at its expense shall
     have the right, upon ten day's notice and not more than once annually, to
     have its independent auditors review at the premises of BN, GRFCO or OTJV
     all the books and records which are directly relevant to and which form the
     basis for the royalty or license fee calculations and the quarterly reports
     made hereunder. To the extent that GRF final product sales are carried out
     by one or more collaborating entities other than BN, GRFCO or OTJV, which
     are not under the control of such companies, BN, GRFCO and OTJV shall use
     their respective best efforts to obtain access for such auditor to the
     pertinent books and records of each such entity. Such independent auditor
     shall be responsible for maintaining the confidentiality of the information
     obtained from any such review and will execute an appropriate
     confidentiality agreement in this connection.

3.   CBC (or its successor or assign) will be paid on a quarterly basis
     [CONFIDENTIAL TREATMENT REQUESTED] of all license fees received by GRFCO,
     OTJV or BN or their successors or affiliates which are paid relative to the
     licensing of GRF Technology which has been or shall be discovered,
     developed or acquired by GRFCO, BN or OTJV or any of their successors or
     affiliates prior to July 15, 2001. The term "license fee" shall include
     whether characterized as a license fee


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     or otherwise, without limitation, any initial lump sum payment made for the
     acquisition of rights to GRF Technology and/or the rights to distribute GRF
     finished products and/or any amounts paid for such an acquisition or
     retention of rights upon the happening of prescribed subsequent events or
     milestones. The term "license fee" shall not include payments received to
     the extent that such payments are reimbursements for costs for research and
     development activities.

4.   GRFCO, BN or OTJV, or any of their respective shareholders, successors or
     assigns, shall have the right without limitation to purchase, buy out and
     fully terminate all royalty and license fee payments, and all other rights
     and obligations of any nature whatever, which are conferred on CBC or its
     successors or assigns or which may be owed to or payable to CBC and its
     successors and assigns under the provisions of this settlement agreement by
     any and all of GRFCO, BN or OTJV (or any of their successors or assigns),
     by making a cash payment (in the form of a bank cheque or wire transfer) to
     CBC (or its successor or assign owning such rights) of $7 million, if made
     on or before December 31, 2002, or $12 million, if made between January 1,
     2003 and the close of business on December 31, 2006. Upon completion of any
     such cash payment, CBC or its successors or assigns, as the case may be,
     shall deliver such documentation in respect to the termination of all such
     rights and obligations under this agreement as well as the termination of
     this agreement as the entity making such payment may reasonably require.

5.   Effective as of the Closing under this settlement agreement, and except as
     otherwise specifically provided in this agreement, BN, CBC (and its
     successor or assign, as applicable), OTJV and GRFCO, each for itself and
     its successors in interest, hereby release each and every other such entity
     from all claims of any nature which were or could have been asserted by any
     one such entity against another arising out of or relating to the
     negotiation, execution or implementation of the Joint Venture Agreement. At
     the Closing, OTJV, BN, GRFCO and CBC (and its successor or assign) shall
     deliver such other documentation as may be reasonably required,
     respectively, by CBC, OTJV, BN or GRFCO to further evidence such release.

6.   Effective as of the Closing under this settlement agreement, GRFCO, BN and
     OTJV agree to the termination and release of any and all obligations or
     responsibilities of CBC, and its successors and assigns, which had or may
     have existed on or prior to this date and at any time in the future,
     relative to research on, development, communicating or licensing to GRFCO
     of any technology for the non-injection delivery of GRF, whether pursuant
     to the Joint Venture Agreement, the CBC License Agreement entered into in
     conjunction with the Joint Venture Agreement or otherwise. GRFCO, BN, OTJV
     and CBC hereby agree that effective as of the Closing, the CBC License
     Agreement and the CBC Option and Contribution Agreement are hereby
     terminated and shall be void and without recourse to any party. Without
     limiting the generality of the foregoing, GRFCO shall no longer have any
     rights to CBC Patents and Know-How, as defined in the CBC License
     Agreement. At the Closing, GRFCO, OTJV and BN shall deliver such other
     documentation as may be reasonably required by CBC to evidence the
     termination of such agreements.


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7.   OTJV, BN and GRFCO hereby jointly and severally represent that they have
     informed CBC of all material matters pertaining to the Pilot Study and the
     development and marketing of GRF Technology and have provided CBC with all
     data and test results which would have a material bearing upon CBC's
     evaluation of the GRF Technology and the transfer of its joint venture
     interest pursuant to the terms hereof, including any discussions by
     representatives or agents of OTJV, BN or GRFCO of prospective funding
     sources for further development or marketing of GRF Technology.

8.   The foregoing provisions of this settlement agreement not withstanding, CBC
     on behalf of itself and its successors and assigns shall safeguard and
     maintain all proprietary and confidential information relative to GRF
     Technology which it has heretofore received under the Joint Venture
     Agreement and which it and/or its successors and assigns may hereafter
     receive in connection with this agreement in accordance with the provisions
     of Article VII of the Joint Venture Agreement, which provisions for this
     purpose shall be incorporated in this agreement by reference.

9.   Subject to and contingent upon CBC presenting for approval this settlement
     agreement by the Bankruptcy Court as part of the CBC Plan of
     Reorganization, BN, and OTJV each agrees to withdraw its objections before
     or at the hearing on July 15, 1996 relative to the confirmation of such
     Plan and to the assumption and assignment by CBC of the Joint Venture
     Agreement (as changed by the provisions hereof) and this settlement
     agreement.

If these terms and conditions are agreeable, please sign and return one copy of
this settlement agreement, which shall constitute a binding agreement among the
respective parties hereto, subject only to approval of the Bankruptcy Court.

CAMBRIDGE BIOTECH CORPORATION ("CBC")


/s/ Alison Taunton-Rigby
-------------------------
Alison Taunton-Rigby
President and Chief Executive Officer,
duly authorized


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Agreed and accepted as of the above date by:

BIONEBRASKA, INC. ("BN")


/s/ Thomas R. Coolidge
----------------------
Thomas R. Coolidge
Chairman of the Board and CEO,
duly authorized


OT COMPANY ("OTJV")


/s/ Thomas R. Coolidge
----------------------
Thomas R. Coolidge
President, duly authorized


GRF CORPORATION ("GRFCO")


/s/ Thomas R. Coolidge
----------------------
Thomas R. Coolidge
President, duly authorized


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