<PAGE>
BIEX LETTERHEAD
June 23, 1998
Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, DC 20549
Re: Biex, Inc.
SEC File No: 333-48045
Ladies and Gentlemen:
Pursuant to Rule 477 of the Securities Act of 1933, as amended, Biex, Inc. (the
"Registrant") hereby requests withdrawal of its Registration Statement on Form
S-1 (SEC File No. 333-48045) on the grounds that current market conditions do
not support a public offering of the Registrant's Common Stock at this time.
Sincerely,
Biex, Inc.
By: /s/ James A. Edlund
--------------------------------------
James A. Edlund
President and Chief Executive Officer
cc: Shelley E. Parratt
Thomas Jones
Jennifer Hardy
Robert Littlepage
Christopher Mitchell
Issac Vaughn
Howard Ervin
Michael Sullivan