CADUS PHARMACEUTICAL CORP
S-8, 1997-02-14
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                                        Registration No. 33-____

================================================================================

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                              --------------------

                                    FORM S-8
                             REGISTRATION STATEMENT
                                      UNDER
                           THE SECURITIES ACT OF 1933

                        CADUS PHARMACEUTICAL CORPORATION
- --------------------------------------------------------------------------------
             (Exact name of registrant as specified in its charter)

                                    Delaware
                              --------------------
         (State or other jurisdiction of incorporation or organization)

                                   13-3660391
                              --------------------
                      (I.R.S. Employer Identification No.)

           777 Old Saw Mill River Road, Tarrytown, New York 10591-6705
- --------------------------------------------------------------------------------
                    (Address of Principal Executive Offices)

             Cadus Pharmaceutical Corporation 1993 Stock Option Plan
              Cadus Pharmaceutical Corporation 1996 Incentive Plan
              Written Compensation Contracts with Certain Employees
           Written Compensation Contracts with Non-Employee Directors
             Written Compensation Contracts with Certain Consultants
             -------------------------------------------------------
                            (Full Title of the Plan)

                                 Jeremy M. Levin
                        Cadus Pharmaceutical Corporation
                           777 Old Saw Mill River Road
                         Tarrytown, New York 10591-6705
                         ------------------------------
                     (Name and Address of Agent For Service)
                                 (914) 345-3344
                              --------------------
          (Telephone Number, Including Area Code, of Agent For Service)

                        Copy to: Salomon R. Sassoon, Esq.
                     Morrison Cohen Singer & Weinstein, LLP
                              750 Lexington Avenue
                            New York, New York 10022
                                 (212) 735-8600

================================================================================

<PAGE>

                         CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
================================================================================================================
Title of Securities    Amount to be       Proposed Maximum            Proposed Maximum           Amount of
 to be Registered       Registered    Offering Price Per Share    Aggregate Offering Price    Registration Fee
================================================================================================================
<S>                      <C>               <C>                        <C>                      <C>
Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted under 1993
Stock Option Plan        589,614                 $3.15(1)             $2,069,545.14                   $627.14
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
and stock
appreciation rights
which may be granted
under 1996 Incentive
Plan                     464,470                $15.50(2)                $7,199,285                 $2,181.60
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted under 1996
Incentive Plan           368,864                 $6.625(3)               $2,443,724                   $740.52
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Philip N.
Sussman under a
Written Compensation
Contract                 33,334                  $3.60                   $120,002.40                  $36.36
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to John
Manfredi under a
Written Compensation
Contract                 13,334                  $3.60                    $48,002.40                  $14.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Andrew
Murphy under a
Written Compensation
Contract                 13,334                  $3.60                    $48,002.40                  $14.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Jeremy
Paul under a Written
Compensation
Contract                 13,334                  $3.60                    $48,002.40                  $14.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Lauren
Silverman under a
Written Compensation
Contract                 13,334                  $3.60                    $48,002.40                  $14.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Joshua
Trueheart under a
Written Compensation
Contract                 13,334                  $3.60                    $48,002.40                  $14.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to James S.
Rielly under a
Written Compensation
Contract                  6,667                  $3.60                    $24,001.20                  $ 7.27
================================================================================================================
</TABLE>

<PAGE>

<TABLE>
================================================================================================================
<S>                      <C>               <C>                        <C>                      <C>
Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Thomas F.
Deuel under a
Written Compensation
Contract                  6,667                  $3.60                    $24,001.20                  $ 7.27
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Norman R.
Klinman under a
Written Compensation
Contract                  6,667                  $3.60                    $24,001.20                  $ 7.27
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Elliott
M. Ross under a
Written Compensation
Contract                  5,501                  $3.60                    $19,803.60                  $ 6.00
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Jeremy
Thorner under a
Written Compensation
Contract                  6,667                  $3.60                    $24,001.20                  $ 7.27
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Arnold
Levine under a
Written Compensation
Contract                  6,667                  $3.60                    $24,001.20                  $ 7.27
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to John
Ransom under a
Written Compensation
Contract                  5,040                  $3.60                    $18,144                     $ 5.50
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Christine
Klein under a
Written Compensation
Contract                  4,667                  $3.60                    $16,801.20                  $ 5.09
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Suzanne
K. Wakamoto under a
Written Compensation
Contract                  2,500                  $3.60                     $9,000                     $ 2.73
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to
Christopher Pleiman
under a Written
Compensation
Contract                  1,667                  $3.60                     $6,001.20                  $  .82
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Algis
Anilionis under a
Written Compensation
Contract                  1,000                  $3.60                     $3,600.00                  $ 1.09
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Anupama
K. Nadkarni under a
Written Compensation
Contract                    834                  $3.60                     $3,002.40                  $ 0.91
================================================================================================================
</TABLE>

<PAGE>

<TABLE>
================================================================================================================
<S>                      <C>               <C>                        <C>                      <C>
Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Mitchell
Silverstein under a
Written Compensation
Contract                    834                  $3.60                     $3,002.40                  $ 0.91
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Michael
A. Spruyt under a
Written Compensation
Contract                    834                  $3.60                     $3,002.40                  $ 0.91
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to David
Fruhling under a
Written Compensation
Contract                    250                  $3.60                     $3,002.40                  $ 0.27
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Theodore
Altman under a
Written Compensation
Contract                 12,000                  $6.75                    $81,000                     $24.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Harold
First under a
Written Compensation
Contract                 12,000                  $6.75                    $81,000                     $24.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Carl
Icahn under a
Written Compensation
Contract                 12,000                  $6.75                    $81,000                     $24.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Peter
Liebert under a
Written Compensation
Contract                 12,000                  $6.75                    $81,000                     $24.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Robert
Mitchell under a
Written Compensation
Contract                 12,000                  $6.75                    $81,000                     $24.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Mark
Rachesky under a
Written Compensation
Contract                 12,000                  $6.75                    $81,000                     $24.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to William
Scott under a
Written Compensation
Contract                 12,000                  $6.75                    $81,000                     $24.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Jack
Wasserman under a
Written Compensation
Contract                 12,000                  $6.75                    $81,000                     $24.55
================================================================================================================
</TABLE>

<PAGE>

<TABLE>
================================================================================================================
<S>                      <C>               <C>                        <C>                      <C>
Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Samuel D.
Waksal under a
Written Compensation
Contract                 12,000                  $6.75                    $81,000                     $24.55
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to John C.
Cambier under a
Written Compensation
Contract                166,667                  $1.50                   $250,000.50                  $75.76
================================================================================================================

Common Stock, par
value $0.01 per
share, issuable upon
exercise of options
granted to Gary L.
Johnson, under a
Written Compensation
Contract                166,667                  $1.50                   $250,000.50                  $75.76
================================================================================================================

Common Stock, par
value $0.01 issuable
upon exercise of
options granted to
James R. Broach,
under a Written
Compensation
Contract                141,667                  $2.571                  $364,225.85                 $110.37
================================================================================================================

                     Total Registration Fee . . . . . . . . . . . . . .  $  4,202.75

================================================================================================================
</TABLE>

- ----------
(1)   Calculated at the highest price at which any option granted under the 1993
      Stock Option Plan is exercisable.
(2)   Estimated in accordance with Rules 457(c) and (h) solely for the purpose
      of calculating the registration fee and based upon the average of the high
      and low trade prices of the Common Stock of Cadus Pharmaceutical
      Corporation as reported by the NASDAQ Stock Market on February 10, 1997.
(3)   Calculated at the highest price at which any option granted under the 1996
      Incentive Plan is exercisable.

<PAGE>

                                     PART II

               INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference.

      The following documents (or parts thereof) filed or to be filed with the
Securities and Exchange Commission (the "Commission") by Cadus Pharmaceutical
Corporation (the "Company") are incorporated by reference in this registration
statement:

      (a) The Company's Prospectus, dated July 17, 1996;

      (b) The Company's Quarterly Report on Form 10-Q for the fiscal quarter
ended September 30, 1996;

      (c) All other reports filed by the Company pursuant to Section 13(a) and
15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"),
since July 17, 1996, the effective date of the Prospectus referred to in (a)
above;

      (d) The description of the Company's common stock, $0.01 par value per
share (the "Common Stock"), contained in the Company's registration statement on
Form 8-A filed on June 18, 1996 (and which became effective on July 17, 1996)
pursuant to Section 12(g) of the Exchange Act.

      All documents subsequently filed by the Company pursuant to Sections
13(a), 13(c), 14 and 15(d) of the Exchange Act, prior to the filing of a
post-effective amendment which indicates that all securities offered hereby have
been sold or which deregisters all securities then remaining unsold, shall be
deemed to be incorporated by reference in this Registration Statement and to be
part hereof from the date of filing of such documents.

      The exhibit index appears on page 7 of this Registration Statement.

Item 4. Description of Securities

      Not applicable.

Item 5. Interests of Named Experts and Counsel

      Not Applicable.


                                       1
<PAGE>

Item 6. Indemnification of Directors and Officers

      Section 145 of the Delaware General Corporation Law provides for the
indemnification of officers, directors, and other corporate agents in terms
sufficiently broad to indemnify such persons under certain circumstances for
liabilities (including reimbursement of expenses incurred) arising under the
Securities Act of 1933, as amended (the "Securities Act"). Article Eighth of the
Company's Amended and Restated Certificate of Incorporation and Section 6.4 of
the Company's By-Laws provides for indemnification to the fullest extent
authorized by the Delaware General Corporation Law. The Company has also entered
into agreements with each of its directors (other than Mr. Icahn) that provide
for the indemnification of and the advancement of expenses to such persons to
the greatest extent permitted by Delaware law.

Item 7. Exemption from Registration Claimed

      Not Applicable.

Item 8. Exhibits

      4.1   Cadus Pharmaceutical Corporation 1993 Stock Option Plan
            (incorporated by reference to Exhibit 10.2 to the Company's
            Registration Statement on Form S-1, as amended (Commission File
            Number 333-4441), which became effective on July 17, 1996).

      4.2   Cadus Pharmaceutical Corporation 1996 Incentive Plan (incorporated
            by reference to Exhibit 10.3 to the Company's Registration Statement
            on Form S-1, as amended (Commission File Number 333-4441), which
            became effective on July 17, 1996).

      4.2.1 Amendment to Cadus Pharmaceutical Corporation 1996 Incentive Plan.

      4.2.2 Form of Incentive Stock Option Agreement utilized in connection with
            issuances of incentive stock options under the Cadus Pharmaceutical
            Corporation 1996 Incentive Plan.

      4.3   Form of Stock Option Agreement, made as of December 19, 1995,
            between Cadus Pharmaceutical Corporation and each of the following
            employees of the Company: Philip N. Sussman, John Manfredi, Andrew
            Murphy, Jeremy Paul, Lauren Silverman, Joshua Trueheart, James S.
            Rielly, Thomas F. Deuel, Norman R. Klinman, Elliott M. Ross, Jeremy
            Thorner, Arnold Levine, John Ransom, Christine Klein, Suzanne K.
            Wakamoto, Christopher Pleiman, Algis Anilionis, Anupama K. Nadkarni,
            Mitchell Silverstein, Michael A. Spruyt, and David Fruhling.


                                       2
<PAGE>

      4.4   Stock Option Agreement, dated as of November 1, 1994, between Cadus
            Pharmaceutical Corporation and John C. Cambier (incorporated by
            reference to Exhibit 10.21 to the Company's Registration Statement
            on Form S-1, as amended (Commission File Number 333-4441), which
            became effective on July 17, 1996).

      4.5   Stock Option Agreement, dated as of November 1, 1994, between Cadus
            Pharmaceutical Corporation and Gary L. Johnson (incorporated by
            reference to Exhibit 10.22 to the Company's Registration Statement
            on Form S-1, as amended (Commission File Number 333-4441), which
            became effective on July 17, 1996).

      4.6   Stock Option Agreement, dated as of December 18, 1995, between Cadus
            Pharmaceutical Corporation and James R. Broach (incorporated by
            reference to Exhibit 10.26 to the Company's Registration Statement
            on Form S-1, as amended (Commission File Number 333-4441), which
            became effective on July 17, 1996).

      4.7   Form of Stock Option Agreement, made as of November 15, 1996,
            between Cadus Pharmaceutical Corporation and each of the following
            non-employee directors of the Company: Theodore Altman, Harold
            First, Carl Icahn, Peter Liebert, Robert Mitchell, Mark Rachesky,
            William Scott, Jack Wasserman, and Samuel D. Waksal.

      4.8   Specimen of Common Stock certificate of Cadus Pharmaceutical
            Corporation (incorporated by reference to Exhibit 4.1 to the
            Company's Registration Statement on Form S-1, as amended (Commission
            File Number 333-4441), which became effective on July 17, 1996).

      4.9   Amended and Restated Certificate of Incorporation of Cadus
            Pharmaceutical Corporation filed with the Secretary of the State of
            Delaware on July 22, 1996.

      4.10  By-Laws, as amended (incorporated by reference to Exhibit 3.4 to the
            Company's Registration Statement on Form S-1, as amended (Commission
            File Number 333- 4441), which became effective on July 17, 1996).

      5.    Opinion of Morrison Cohen Singer & Weinstein, LLP, as to the
            validity of the securities being registered.

      23.1  Consent of KPMG Peat Marwick LLP.

      23.2  Consent of Morrison Cohen Singer & Weinstein, LLP (contained in its
            Opinion filed as part of Exhibit 5).

      24.   Powers of Attorney (included on the signature page of the
            registration statement filed February 14, 1997).


                                       3
<PAGE>

Item 9. Undertakings

      A.    The undersigned registrant hereby undertakes:

            (1) To file, during any period in which offers or sales are being
made, a post-effective amendment to this registration statement:

                  (i) To include any prospectus required by Section 10(a)(3) of
the Securities Act of 1933, as amended (the "Securities Act");

                  (ii) To reflect in the prospectus any facts or events arising
after the effective date of the registration statement (or the most recent
post-effective amendment thereof) which, individually or in the aggregate,
represent a fundamental change in the information set forth in the registration
statement;

                  (iii) To include any material information with respect to the
plan of distribution not previously disclosed in the registration statement or
any material change to such information in the registration statement;

                  provided, however, that paragraphs A(1)(i) and A(1)(ii) do not
apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in periodic reports filed with or furnished to
the Commission by the registrant pursuant to Section 13 or 15(d) of the Exchange
Act that are incorporated by reference in the registration statement.

            (2) That, for the purpose of determining any liability under the
Securities Act, each such post-effective amendment shall be deemed to be a new
registration statement relating to the securities offered therein, and the
offering of such securities at that time shall be deemed to be the initial bona
fide offering thereof.

            (3) To remove from registration by means of a post-effective
amendment any of the securities being registered which remain unsold at the
termination of the offering.

      B. The undersigned registrant hereby undertakes that, for purposes of
determining any liability under the Securities Act, each filing of the
registrant's annual report pursuant to Section 13(a) or 15(d) of the Exchange
Act (and, where applicable, each filing of an employee benefit plan's annual
report pursuant to Section 15(d) of the Exchange Act) that is incorporated by
reference in the registration statement shall be deemed to be a new registration
statement relating to the securities offered therein, and the offering of such
securities at that time shall be deemed to be the initial bona fide offering
thereof.

      H. Insofar as indemnification for liabilities arising under the Securities
Act may be permitted to directors, officers and controlling persons of the
registrant pursuant to the foregoing provisions, or otherwise, the registrant
has been advised that in the opinion of the Commission such


                                       4
<PAGE>

indemnification is against public policy as expressed in the Securities Act and
is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the registrant of expenses
incurred or paid by a director, officer or controlling person of the registrant
in the successful defense of any action, suit or proceeding) is asserted by such
director, officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been settled by controlling precedent, submit to a court of appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Securities Act and will be governed by the final
adjudication of such issue.


                                       5
<PAGE>

                                   SIGNATURES

            Pursuant to the requirements of the Securities Act of 1933, as
amended, the registrant certifies that it has reasonable grounds to believe that
it meets all of the requirements for filing on Form S-8 and has duly caused this
registration statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Tarrytown, State of New York, on this 14th day
of February, 1997.

                                       CADUS PHARMACEUTICAL CORPORATION

                                       By: s/Jeremy M. Levin
                                           -------------------------------------
                                           Jeremy M. Levin
                                           President and Chief Executive Officer

                                POWER OF ATTORNEY

            KNOW ALL PERSONS BY THESE PRESENTS, that each person whose signature
appears below constitutes and appoints Jeremy M. Levin and James S. Rielly, or
either of them, each with the power of substitution, his or her
attorney-in-fact, to sign any amendments to this registration statement and to
file the same, with exhibits thereto and other documents in connection
therewith, with the Securities and Exchange Commission, hereby ratifying and
confirming all that each of said attorney-in-fact, or his or her substitute, may
do or choose to be done by virtue hereof.

            Pursuant to the requirements of the Securities Act of 1933, as
amended, this registration statement has been signed below by the following
persons in the capacities and on the dates indicated:

      Signature                          Title                      Date
      ---------                          -----                      ----
S/Jeremy M. Levin          President and Chief Executive      February 14, 1997
- ----------------------     Officer (Principal Executive 
   Jeremy M. Levin         Officer) and Chairman of the 
                           Board of Directors
                           
                           
S/James S. Rielly          Director of Finance, Controller,   February 14, 1997
- ----------------------     Treasurer and Secretary 
   James S. Rielly         (Principal Financial and 
                           Accounting Officer)
                           
                           
                           Director                           February ___, 1997
- ----------------------     
  Carl C. Icahn            
                           
                           
                           Director                           February ___, 1997
- ----------------------     
  Theodore Altman          
                           
                           
                           Director                           February ___, 1997
- ----------------------     
  Harold First             
                           
                           
S/Peter Liebert            Director                           February 14, 1997
- ----------------------     
  Peter Liebert            
                           
                           
S/Robert Mitchell          Director                           February 14, 1997
- ----------------------     
  Robert Mitchell          
                           
                           
S/Lawrence Muschek         Director                           February 14, 1997
- ----------------------     
  Lawrence Muschek         
                           
                           
                           Director                           February ___, 1997
- ----------------------     
  Mark H. Rachesky         
                           
                           
 S/Nicole Vitullo          Director                           February 14, 1997
- ----------------------     
  Nicole Vitullo           
                           
                           
                           Director                           February ___, 1997
- ----------------------     
  Samuel D. Waksal         
                           
                           
S/Jack G. Wasserman        Director                           February 14, 1997
- ----------------------     
  Jack G. Wasserman        


                                       6
<PAGE>

                                  EXHIBIT INDEX

No.      Description
- ---      -----------

4.1      Cadus Pharmaceutical Corporation 1993 Stock
         Option Plan (incorporated by reference).

4.2      Cadus Pharmaceutical Corporation 1996 Incentive
         Plan (incorporated by reference).

4.2.1    Amendment to Cadus Pharmaceutical Corporation 1996 Incentive Plan

4.2.2    Form of Incentive Stock Option Agreement utilized in connection with
         issuances of incentive stock options under the Cadus Pharmaceutical
         Corporation 1996 Incentive Plan.

4.3      Form of Stock Option Agreement between Cadus Pharmaceutical
         Corporation and each of the following employees of the Company: Philip
         N. Sussman, John Manfredi, Andrew Murphy, Jeremy Paul, Lauren
         Silverman, Joshua Trueheart, James S. Rielly, Thomas F. Deuel,
         Norman R. Klinman, Elliott M. Ross, Jeremy Thorner, Arnold
         Levine, John Ransom, Christine Klein, Suzanne K. Wakamoto,
         Christopher Pleiman, Algis Anilionis, Anupama K.
         Nadkarni, Mitchell Silverstein, Michael A. Spruyt, and David Fruhling.

4.4      Stock Option Agreement, dated as of November 1, 1994, between Cadus
         Pharmaceutical Corporation and John C. Cambier (incorporated by
         reference).

4.5      Stock Option Agreement, dated as of November 1, 1994, between Cadus
         Pharmaceutical Corporation and Gary L. Johnson (incorporated by
         reference).

4.6      Stock Option Agreement, dated as of December 18, 1995, between Cadus
         Pharmaceutical Corporation and James R. Broach (incorporated by
         reference).

4.7      Form of Stock Option Agreement between Cadus Pharmaceutical
         Corporation and each of the following non-employee directors of the
         Company: Theodore Altman, Harold First, Carl Icahn, Peter Liebert,
         Robert Mitchell, Mark Rachesky, William Scott, Jack Wasserman,
         and Samuel D. Waksal.

4.8      Specimen of Common Stock certificate of Cadus Pharmaceutical
         Corporation (incorporated by reference).

4.9      Amended and Restated Certificate of Incorporation of Cadus
         Pharmaceutical Corporation filed with the Secretary of State of the
         State of Delaware on July 22, 1996.

4.10     By-Laws, as amended (incorporated by reference).

5.       Opinion of Morrison Cohen Singer & Weinstein, LLP, as to the
         validity of the securities being registered.

23.1     Consent of KPMG Peat Marwick LLP.

23.2     Consent of Morrison Cohen Singer & Weinstein, LLP (contained in its
         Opinion filed as Exhibit 5).

24.      Powers of Attorney (included on the signature page of the
         registration statement filed February 14, 1997).


                                       7



                                AMENDMENT NO. 1
                                       TO
                        CADUS PHARMACEUTICAL CORPORATION
                              1996 INCENTIVE PLAN

      This Amendment No. 1 to the Cadus Pharmaceutical Corporation 1996
Incentive Plan (the "Plan") was adopted by the Board of Directors of Cadus
Pharmaceutical Corporation on December 12, 1996.

            1. All references in the Plan to the par value of the common stock
of Cadus Pharmaceutical Corporation is hereby amended from "$0.001" per share to
"$0.01" per share.

            2. The last sentence of Section 1.1 is hereby amended to read as
follows:

            "Upon approval of the Plan by the Board of Directors of the
            Corporation (the "Board"), awards may be made by the Board or the
            Board's Compensation Committee (the "Committee"), as provided
            herein."

            3. The first sentence of Section 2.2 of the Plan is hereby amended
to read as follows:

            "2.2 Maximum Shares Available. The maximum aggregate number of
shares of Common Stock available for award under the Plan is 833,334, subject to
adjustment pursuant to Article 12 hereof. The maximum aggregate number of shares
of Common Stock or Options or Stock Appreciation Rights with respect thereto
that may be awarded under the Plan to any individual during any calendar year is
300,000, subject to adjustment pursuant to Article 12 hereof."

            4. Section 3.1 of the Plan is hereby amended in its entirety to read
as follows:

            "3.1 Committee. Awards shall be determined, and the Plan shall be
administered, by the Board or the Committee. Whenever the Plan grants power and
authority to the Committee it shall also be deemed to have granted the same
power and authority to the Board. The Committee shall be appointed from time to
time by the Board, which Committee shall consist of not less than two (2)
members of the Board; provided, however, that in order to permit transactions
pursuant to the Plan by employees of the Corporation to be exempt from the
provisions of Section 16(b) of the Securities Exchange Act of 1934, as amended
(the "1934 Act"), each member of the Committee shall be a "Non-Employee
Director," as that term is defined in subparagraph (b)(3)(i) of Rule 16b-3
promulgated under the 1934 Act, as in effect from time to time ("Rule 16b-3");
and provided further, however, that each member of the Committee shall also be
an "outside director" as that term is defined in Treasury Regulation Section
1.162-27(e)(3).

<PAGE>

            5. The proviso in the first sentence of Section 3.3 of the Plan is
hereby amended to read as follows:

            "provided, however, that the Committee may not delegate any of its
            responsibilities hereunder to any director who is not a
            "Non-Employee Director," as that terms is defined in subparagraph
            (b)(3)(i) of Rule 16b-3."

            6. The first paragraph of Article 4 of the Plan is hereby amended to
read as follows:

            "Awards may be made to all directors, employees and consultants of
the Corporation or any of its subsidiaries (subject to such requirements as may
be prescribed by the Board or the Committee). In determining the directors,
employees and consultants to whom awards shall be granted and the number of
shares to be covered by each award, the Board and the Committee shall take into
account the nature of the services rendered by such directors, employees and
consultants, their present and potential contributions to the success of the
Corporation and its subsidiaries and such other factors as the Board or the
Committee in its sole discretion shall deem relevant."



                                                                   EXHIBIT 4.2.2

      THE OPTION GRANTED PURSUANT TO THIS INCENTIVE STOCK OPTION AGREEMENT (THE
      "OPTION") AND THE SHARES OF COMMON STOCK ISSUABLE UPON THE EXERCISE HEREOF
      HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
      "SECURITIES ACT"), AND MAY NOT BE PLEDGED, HYPOTHECATED, SOLD, TRANSFERRED
      OR OTHERWISE DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE REGISTRATION
      STATEMENT FOR THE OPTION OR THE SHARES UNDER THE SECURITIES ACT, OR AN
      OPINION OF COUNSEL, WHICH IS SATISFACTORY TO THE COMPANY AND ITS COUNSEL,
      THAT SUCH REGISTRATION IS NOT REQUIRED.

                        CADUS PHARMACEUTICAL CORPORATION
                               1996 INCENTIVE PLAN

                        INCENTIVE STOCK OPTION AGREEMENT

      This Incentive Stock Option Agreement (this "Agreement") is effective as
of __________ 1996, between Cadus Pharmaceutical Corporation, a Delaware
corporation (the "Company"), and _________________ (the "Optionee").

                                   WITNESSETH:

      WHEREAS, the Company's Board of Directors established the 1996 Incentive
Plan of Cadus Pharmaceutical Corporation (the "Plan") and the Plan was approved
by the stockholders of the Company; and

      WHEREAS, the Compensation Committee of the Board of Directors of the
Company (the "Committee") has granted this Option to the Optionee;

      NOW, THEREFORE, in consideration of the mutual covenants hereinafter
contained, the parties hereto agree as follows:

      1. Grant of Option

            (a) Option. On the terms and conditions set forth in the Plan and
this Agreement, the Company hereby grants to the Optionee this Option to
purchase an aggregate of _________ shares of common stock, $.01 par value per
share, of the Company (the "Shares") at a price of $____ per Share, such
exercise price being, in the judgment of the Committee, equal to the "Market
Price" (as defined in the Plan) of a Share at the date hereof. This Option is
intended to qualify as an "incentive stock option" under Section 422 of the
Internal Revenue Code of 1986, as amended (the "Code"), and shall be construed
accordingly.


<PAGE>

            (b) Stock Option Plan. This Option is granted pursuant to the Plan,
a copy of which the Optionee acknowledges having received, read and understood.
The provisions of the Plan are hereby incorporated into this Agreement.

      2. Right to Exercise.

            Subject to the terms and conditions of the Plan and this Agreement,
this Option shall become exercisable in four equal installments. Each
installment shall consist of twenty-five percent (25%) of the total number of
Shares subject to this Option. Such installments shall become exercisable on the
first, second, third and fourth anniversaries of ________. The number of Shares
included in each installment shall be rounded to the nearest integer.

      3. No Transfer.

            This Option is not transferable by Optionee otherwise than by will
or the laws of descent and distribution. During the Optionee's lifetime, this
Option is only exercisable by Optionee.

      4. Exercise Procedures.

            (a) Notice of Exercise. The Optionee or the Optionee's
representative may exercise this Option by giving written notice to the
Secretary of the Company in the manner provided in the Plan and substantially in
the form annexed hereto as Exhibit A. The notice shall specify the election to
exercise this Option, the number of Shares for which it is being exercised and
the form of payment (if more than one form is available). The notice shall be
signed by the person exercising this Option. In the event that this Option is
being exercised by the representative of the Optionee, the notice shall be
accompanied by proof (satisfactory to the Company) of the representative's right
to exercise this Option. The Optionee or the Optionee's representative shall
deliver to the Secretary of the Company, at the time of giving the notice,
payment in a form permissible under Section 5 for the full amount of the
exercise price applicable to that portion of the Option being exercised.

            (b) Issuance of Shares. After receiving a proper notice of exercise,
the Company shall cause to be issued a certificate or certificates for the
Shares as to which this Option has been exercised, registered in the name of the
person exercising this Option. The Company shall cause such certificate or
certificates to be delivered to or upon the order of the person exercising this
Option.

            (c) Withholding Taxes. In the event that the Company determines that
it is required to withhold foreign, federal, state or local tax as a result of
the exercise of this Option, the Optionee, as a condition to the exercise of
this Option, shall make arrangements satisfactory to the Company to enable it to
satisfy all withholding


                                       2
<PAGE>

requirements. The Optionee shall also make the arrangements satisfactory to the
Company to enable it to satisfy any withholding requirements that may arise in
connection with the disposition of Shares purchased by exercising this Option.

      5. Payment for Stock.

            (a) Cash. All or part of the exercise price may be paid in lawful
money of the United States of America.

            (b) Surrender of Stock. All or part of the exercise price may be
paid by the surrender of Shares in good form for transfer. Such Shares must have
a Market Price (as determined by the Committee) on the date of exercise of this
Option which, together with any amount paid in another form permissible under
this Section 5, is equal to the aggregate exercise price.

            (c) Exercise/Sale. All or part of the exercise price and any
withholding taxes may be paid by the delivery of an irrevocable direction
(acceptable to the Company) to a securities broker approved by the Company to
sell Shares and to deliver all or part of the sales proceeds to the Company.

            (d) Exercise/Pledge. All or part of the exercise price and any
withholding taxes may be paid by the delivery of an irrevocable direction
(acceptable to the Company) to a securities broker or lender approved by the
Company to pledge Shares as security for a loan and to deliver all or part of
the loan proceeds to the Company.

      6. Term and Expiration.

            This Option shall expire on the day before the tenth anniversary of
the date hereof, unless sooner terminated as provided in the Plan, and may be
exercised during such term only in accordance with the Plan and this Agreement.

      7. No Registration Rights.

            The Company may, but shall not be obligated to, register or qualify
the sale of Shares under the Securities Act or any other applicable law. The
Company shall not be obligated to take any affirmative action in order to cause
the sale of Shares under this Agreement to comply with any law.

      8. Securities Law Restrictions.

            (a) Restrictions. Regardless of whether the offering and sale of
Shares under the Plan have been registered under the Securities Act or have been
registered or qualified under the securities laws of any state, the Company at
its direction may impose restrictions upon the sale, pledge or other transfer of
such Shares (including


                                       3
<PAGE>

the placement of appropriate legends on stock certificates) if, in the judgment
of the Company and its counsel, such restrictions are necessary or desirable in
order to achieve compliance with the Securities Act, the securities laws of any
state or any other law or with restrictions imposed by the Company's
underwriters.

            (b) Investment Intent at Grant. The Optionee represents and agrees
that the Shares to be acquired upon exercising this Option will be acquired for
investment, and not with a view to the sale or distribution thereof.

            (c) Investment Intent at Exercise. In the event that the sale of
Shares under the Plan is not registered under the Securities Act but an
exemption is available which requires an investment representation or other
representation, the Optionee shall represent and agree at the time of exercise
that the Shares being acquired upon exercising this Option are being acquired
for investment, and not with a view to the sale or distribution thereof, and
shall make such other representations as are deemed necessary or appropriate by
the Company and its counsel.

            (d) Legend. All certificates evidencing Shares acquired under this
Agreement in an unregistered transaction shall bear the following restrictive
legend (and such other restrictive legends as are required or deemed advisable
under the provisions of any applicable law):

      "THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
      UNDER THE SECURITIES ACT OF 1933 OR APPLICABLE STATE SECURITIES LAWS.
      THESE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO
      DISTRIBUTION OR RESALE. THESE SECURITIES MAY NOT BE OFFERED FOR SALE,
      SOLD, DELIVERED AFTER SALE, TRANSFERRED, PLEDGED OR HYPOTHECATED IN THE
      ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT COVERING SUCH SECURITIES
      UNDER THE SECURITIES ACT OF 1933 AND ANY APPLICABLE STATE SECURITIES LAWS,
      OR THE AVAILABILITY, IN THE OPINION OF COUNSEL, OF AN EXEMPTION FROM
      REGISTRATION THEREUNDER."

            (e) Administration. Any determination by the Company and its counsel
in connection with any of the matters set forth in this Section 8 shall be
conclusive and binding on the Optionee and all other persons.

      9. Shares and Adjustments.

            (a) General. In the event of a subdivision of the outstanding shares


                                       4
<PAGE>

of common stock of the Company (the "Common Stock"), a stock split, a reverse
stock split, a declaration of a dividend payable in Common Stock, a declaration
of a dividend payable in a form other than Common Stock in an amount that has a
material effect on the value of Common Stock, a combination or consolidation of
the outstanding shares of Common Stock into a lesser number of shares of Common
Stock, a recapitalization, a spinoff, a reclassification or a similar
occurrence, the Committee shall make appropriate adjustments in one or both of
(i) the number of shares of Common Stock covered by this Option or (ii) the
exercise price to prevent dilution or enlargement of the Optionee's rights
hereunder.

            (b) Reorganizations. In the event that the Company is a party to a
merger or other reorganization, this Option shall be subject to the agreement of
merger or reorganization. Such agreement shall provide (i) for the assumption of
outstanding options by the surviving corporation or its parent, (ii) for their
continuation by the Company (if the Company is the surviving corporation), (iii)
for payment of a cash settlement equal to the difference between the amount to
be paid for one Share under such agreement and the exercise price, or (iv) for
the acceleration of their exercisability followed by the cancellation of options
not exercised, in all cases except subsection 9(b)(iii) without the Optionee's
consent. The Optionee's consent shall be required for a cash settlement under
subsection 9(b)(iii) above. Any cancellation shall not occur until after such
acceleration is effective and the Optionee has been given at least 30 days
notice of both such acceleration and the intended date of cancellation.

            (c) Reservation of Rights. Except as provided in this Section 9, the
Optionee shall have no rights by reason of (i) any subdivision or consolidation
of shares of stock of any class, (ii) the payment of any dividend or (iii) any
other increase or decrease in the number of shares of stock of any class. Any
issue by the Company of shares of stock of any class, or securities convertible
into shares of stock of any class, shall not affect, and no adjustment by reason
thereof shall be made with respect to, the number or exercise price of the
Shares subject to this Option. The grant of this Option shall not affect in any
way the right or power of the Company to make adjustments, reclassifications,
reorganizations or changes of its capital or business structure, to merge or
consolidate or to dissolve, liquidate, sell or transfer all or any part of its
business or assets.

      10. "Lock-Up" Agreement.

            The Optionee, if so requested by the Company and an underwriter of
Common Stock or other securities of the company, shall not sell, grant any
option or right to buy or sell, or otherwise transfer or dispose of in any
manner, whether in privately-negotiated or open-market transactions, any Common
Stock or other securities of the Company held by him or which he has the right
to acquire during the 180-day period following the effective date of a
registration statement of the Company filed with the Securities and Exchange
Commission in connection with such offering or such shorter period as such
underwriter shall have advised the Company in writing is adequate to permit


                                       5
<PAGE>

the successful and orderly distribution of such Common Stock or other
securities; provided, however, that such "lock-up" agreement shall be in writing
and in form and substance satisfactory to the Company and such underwriter. The
Company may impose stop-transfer instructions with respect to the shares subject
to the foregoing restrictions until the end of said 180-day period. This Section
10 shall survive the termination or exercise of this Option.

      11. Miscellaneous Provisions.

            (a) Entire Agreement; Amendments. This Agreement and the Plan
constitute the entire agreement between the parties hereto with regard to the
subject matter hereof. This Agreement may not be amended except by a written
instrument signed by both parties hereto.

            (b) Choice of Law. This Agreement shall be governed by, and
construed in accordance with, the laws of the State of Delaware.

      IN WITNESS WHEREOF, the Company has caused this Agreement to be executed
on its behalf by a duly authorized officer and the Optionee has personally
executed this Agreement.

                                             CADUS PHARMACEUTICAL CORPORATION


__________________                           By:______________________________
[Optionee]                                      James S. Rielly, Treasurer

Optionee's Address:


                                       6
<PAGE>

                                                                       EXHIBIT A

                               [Date of Exercise]

Cadus Pharmaceutical Corporation
777 Old Saw Mill River Road
Tarrytown, NY 10591-6705
Attention: Corporate Secretary

               Re:  Stock Option

Dear Sir:

            I am the holder of a stock option granted to me by Cadus
Pharmaceutical Corporation (the "Company"), pursuant to an Incentive Stock
Option Agreement dated as of ___________, to purchase _______________ shares of
Common Stock of the Company ("Shares"). I hereby exercise such option with
respect to ____________ Shares, the total purchase price for which is $________,
and [I enclose a certified, bank cashier's or other acceptable check payable to
the order of the Company in the amount of $________, representing the total
purchase price for the Shares] [I hereby elect to pay the purchase price by
delivering to the Company _____ shares of Common Stock of the Company having a
fair market value equal to $___________ from the Shares I am purchasing pursuant
to the exercise of such option] [I enclose an irrevocable direction to a
securities broker to deliver sales or loan proceeds to the Company in the amount
of $________, representing the total purchase price for the Shares]. The
certificate or certificates representing the Shares should be registered in my
name and should be forwarded to me at _________________________________________.

            Please acknowledge receipt of the exercise of my stock option on the
attached copy of this letter.

                                        Very truly yours,


                                        [OPTIONEE]

RECEIPT  ACKNOWLEDGED:

CADUS PHARMACEUTICAL CORPORATION


By: ___________________________



                                                                     EXHIBIT 4.3

                             STOCK OPTION AGREEMENT


      AGREEMENT made as of December 19, 1995 by and between CADUS PHARMACEUTICAL
CORPORATION (the "Corporation"), a Delaware corporation having offices at 777
Old Saw Mill River Road, Tarrytown, New York 10591-8705, and _________________
("Employee"), residing at ______________________________________________.

                              W I T N E S S E T H:

      WHEREAS, Employee desires to participate in the equity ownership of the
Corporation and the Corporation desires to provide Employee with an added
incentive to remain in the employ of the Corporation by granting to Employee the
right and option, subject to certain conditions, to purchase shares of the
common stock, $.001 par value, of the Corporation (the "Common Stock");

      NOW, THEREFORE, in consideration of the mutual covenants hereinafter
contained, the parties hereto agree as follows:

      1. Grant of Stock Option.

            As an additional inducement to Employee to continue in the employ of
the Corporation, the Corporation hereby grants to Employee the right and option
(the "Option") to purchase from the Corporation One Hundred Thousand (100,000)
shares of Common Stock (the "Shares"), subject to adjustment as provided in
Paragraph 7 hereof, on the terms and subject to the conditions hereinafter set
forth.

      2. Purchase Price.

            Subject to adjustment as provided in Paragraph 7 hereof, the
purchase price (the "Option Purchase Price") to be paid upon exercise of the
Option shall be $1.20 per share.

      3. Exercisability of Option.

            (a) The Option shall be exercisable, on a cumulative basis, during a
period of ten (10) years commencing from the date hereof and terminating at the
close of business on December 19, 2005, as follows:

                  (i) up to ______ Shares subject to the Option may be purchased
by Employee after December 19, 1996;


<PAGE>

                  (ii) up to an additional ______ Shares subject to the Option
may be purchased by Employee after December 19, 1997; 

                  (iii) up to an additional ______ Shares subject to the Option
may be purchased by Employee after December 19, 1998; and

                  (iv) up to an additional ______ Shares subject to the Option
may be purchased by Employee after December 19, 1999.

            (b) The unexercised portion of the Option will automatically and
without notice terminate and become null and void at the close of business on
December 19, 2005. If, however, Employee's employment with the Corporation or
parent or subsidiary corporation terminates before the close of business on
December 31, 2005, the Option will terminate on the applicable date as described
below; provided, however, that none of the events described below shall extend
the period of exercisability of the Option beyond the close of business on
December 31, 2005:

                  (i) the date of termination, if Employee voluntarily
terminates his employment or his employment is terminated by the Corporation for
"cause" (as hereinafter defined);

                  (ii) the expiration of twelve (12) months after Employee's
death or the termination of his employment by reason of his "disability" (as
hereinafter defined); or

                  (iii) the expiration of three (3) months from the date of
termination of Employee's employment by the Corporation without cause.

            (c) For the purposes of this Agreement, the term "cause" shall mean
the commission by Employee of any material act of malfeasance, fraud,
dishonesty, or breach of fiduciary duty against the Corporation or any
unauthorized disclosure of confidential information by Employee. The
determination of cause by the Board of Directors of the Corporation shall be
final and binding for all purposes.

            (d) For purposes of this Agreement, the term "disability" shall mean
such physical or mental illness or incapacity or Employee as shall (i) prevent
Employee from performing his customary services and duties to the Corporation
and (ii) continue during any period of one hundred twenty (120) consecutive days
or for periods aggregating one hundred eighty (180) days in any 365 day period.


                                       2
<PAGE>

      4. Exercise of Option.

            (a) The Option may be exercised by Employee as to all or a portion
of the Shares (but not as to a fractional share of Common Stock) as to which the
Option has become exercisable, at any time within the applicable period
specified in Paragraph 3 hereof, by the giving of written notice of the exercise
thereof to the Corporation in the manner provided in Paragraph 14 hereof and
substantially in the form annexed hereto as Exhibit A, which notice shall be
accompanied by payment in full of the purchase price therefor by certified or
bank cashier's or other acceptable check. Such exercise shall be effective upon
receipt by the Corporation of such written notice and payment; and Employee, to
the extent permitted by law, shall be deemed the owner of the Shares being
purchased as of the close of business on the date of such exercise and payment.
The Corporation shall cause a certificate or certificates representing the
Shares purchased to be delivered to Employee within ten (10) days after the
effective date of such exercise. Employee agrees that such certificate or
certificates shall bear such legend or legends as the Board of Directors of the
Corporation, in its sole discretion, determines to be necessary or appropriate
to prevent a violation of, or to perfect an exemption from, the registration
requirements of the Securities Act of 1933, as amended (the "Securities Act").

            (b) In lieu of the check provided for in subparagraph 4(a) above,
Employee may, at his sole option and to the extent permitted by applicable law,
pay for the purchase price of the Shares being purchased by the exercise of the
Option, by delivering to the Corporation shares of Common Stock (in proper form
for transfer and accompanied by all requisite stock transfer tax stamps or cash
in lieu thereof) owned by Employee having a Fair Market Value (as hereinafter
defined in subparagraph 4(c) hereof) equal to such purchase price. Employee may
elect to make such delivery to the Corporation of shares of Common Stock from
Shares he is purchasing pursuant to his exercise of the Option by including such
election in his notice of exercise.

            (c) The Fair Market Value of a share of Common Stock as of a
particular date (the "Determination Date") shall mean:

                  (i) If the Corporation's Common Stock is traded on an exchange
or is quoted through the National Association of Securities Dealers, Inc.
Automated Quotation ("NASDAQ") National Market System, then the closing or last
sale price, respectively,



                                       3
<PAGE>

reported for the last business day immediately preceding the Determination Date.

                  (ii) If the Corporation's Common Stock is not listed on an
exchange or quoted on the NASDAQ National Market System but is traded in the
over-the-counter market, then the mean of the closing bid and asked prices
reported for the last business day immediately preceding the Determination Date.

                  (iii) Except as provided in subparagraph 4(c)(iv) and 4(c)(v)
below, if the Corporation's Common Stock is not publicly traded, then as
determined in good faith by the Corporation's Board of Directors upon a review
of relevant factors.

                  (iv) If the Determination Date is the date on which the
Corporation's Common Stock is first sold to the public by the Corporation in a
firm commitment public offering under the Securities Act, then the initial
public offering price (before deducting commissions, discounts or expenses) at
which the Common Stock is sold in such offering.

                  (v) If the Determination Date is the date of a liquidation,
dissolution or winding up of the Corporation, then all amounts to be payable per
share to holders of the Common Stock in the event of such liquidation,
dissolution or winding up.

      5. Purchase for Investment.

            Employee agrees that at the request of the Corporation and upon
exercise of the Option, he shall execute and deliver to the Corporation a
written statement, in form satisfactory to the Corporation, representing and
warranting that he is purchasing the Shares for his own account, for investment
only and not with a view to the resale or distribution thereof and that any
subsequent offer for sale or sale of any of such Shares shall be made either
pursuant to (a) a registration statement on an appropriate form under the
Securities Act, which registration statement has become effective and is current
with respect to the shares being offered and sold, or (b) a specific exemption
from the registration requirements of the Securities Act, but in claiming such
exemption Employee shall, prior to any offer for sale or sale of such shares,
obtain a favorable written opinion from counsel for or approved by the
Corporation as to the availability of such exemption.

      6. Non-Transferability of Option.


                                       4
<PAGE>

            The Option shall not be transferable by Employee other than by will
or the laws of descent and distribution.

      7. Adjustment of Shares.

            If any change is made in the Shares deliverable upon exercise of the
Option (through merger, consolidation, reorganization, recapitalization, stock
dividend, stock split, split-up, spin-off, split-off, subdivision or combination
of shares, exchange of shares, issuance of rights to subscribe, change in
capital structure or similar event), such adjustments or substitutions shall be
made by the Board of Directors of the Corporation in or for the Shares
(including adjustments in the number of Shares and in the per share price of
Shares subject to the Option) as the Board of Directors of the Corporation
reasonably shall determine to be appropriate and equitable to prevent dilution
or enlargement of Employee's rights hereunder.

      8. Covenants of the Corporation.

            The Corporation hereby covenants and agrees that:

            (a) During the period within which the Option may be exercised, the
Corporation shall at all times reserve and keep available by all necessary
corporate action out of its shares of Common Stock for the purpose of issuance
or transfer upon exercise of the Option the number of shares of Common Stock
included in the Shares and such additional securities as may from time to time
be deliverable hereunder. Such shares may be authorized but unissued shares, or
may be shares held in the treasury of the Corporation or a combination thereof,
at the option of the Corporation.

            (b) All shares which may be issued upon exercise of the Option or
delivered pursuant to this Agreement will, upon issuance and payment therefor as
provided herein, be validly issued, fully paid, nonassessable and free from all
liens and charges with respect to the issue thereof.

      9. Representations and Warranties of the Corporation.

            The Corporation represents and warrants to Employee as follows:

                  (a) The Corporation is a corporation duly organized, validly
existing and in good standing under the laws of the State of Delaware.


                                       5
<PAGE>

                  (b) The Corporation has all requisite legal and corporate
power to execute this Agreement. The execution, delivery and performance by the
Corporation of this Agreement and the consummation of the transactions
contemplated hereby have been authorized by all necessary corporate action on
the part of the Corporation.

                  (c) This Agreement has been duly executed by the Corporation
and, assuming due and valid execution and delivery of the same by Employee,
constitutes the valid and legally binding obligation of the Corporation
enforceable in accordance with its terms.


                                       6
<PAGE>

      10. No Fractional Shares.

            Upon the exercise of the Option, the Corporation shall not be
required to issue any fractional shares or scrip certificates evidencing any
fractional interest in shares. In any case where, pursuant to the terms of the
Option, Employee would be entitled, except for the provisions of this Paragraph
10, to receive a fractional share, the number of shares issuable upon such
exercise shall be rounded to the next larger whole share if such fractional
share interest is a major fraction; if such fractional share interest is not a
major fraction, it shall be disregarded.

      11. "Lock-Up" Agreement.

            Employee, if so requested by the Corporation and an underwriter of
Common Stock or other securities of the Corporation, shall not sell, grant any
option or right to buy or sell, or otherwise transfer or dispose of in any
manner, whether in privately-negotiated or open-market transactions, any Common
Stock or other securities of the Corporation held by him or which he has the
right to acquire during the 180-day period following the effective date of a
registration statement of the Corporation filed with the Securities and Exchange
Commission in connection with such offering or such shorter period as such
underwriter shall have advised the Corporation in writing is adequate to permit
the successful and orderly distribution of such Common Stock or other
securities; provided, however, that such "lock-up" agreement shall be in writing
and in form and substance satisfactory to the Corporation and such underwriter.
The Corporation may impose stop-transfer instructions with respect to the shares
subject to the foregoing restrictions until the end of said 180-day period. This
Paragraph 11 shall survive the termination or exercise of the Option.

      12. Entire Agreement Amendments.

            This Agreement sets forth the entire understanding of the parties
with respect to the subject matter hereof, and no statement, representation,
warranty or covenant has been made by either party except as expressly set forth
herein. This Agreement supersedes and cancels all prior agreements between the
parties, whether written or oral, with respect to the subject matter hereof. No
alteration, amendment or modification of any of the terms and provisions hereof
shall be valid unless made pursuant to a written instrument signed by all of the
parties hereto.

      13. Applicable Law.


                                       7
<PAGE>

            This Agreement shall be governed by, and construed and enforced in
accordance with, the laws of the State of Delaware.

      14. Notices.

            All notices, requests, demands and other communications hereunder
shall be in writing and shall be deemed to have been duly given if delivered
personally or mailed, first class, postage prepaid, certified mail, return
receipt requested, to the other party at its address as set forth at the
beginning of this Agreement or as either of the parties may designate in
conformity with the foregoing.

      15. Paragraph Headings.

            The paragraph headings set forth in this Agreement are for reference
purposes only and shall not be considered as part of this Agreement in any
respect nor shall they in any way affect the substance of any provisions
contained in this Agreement.

      16. Successors and Assigns.

            This Agreement shall not be assignable by Employee, but the rights
hereunder may be transferred as described in Paragraph 6 hereof. All of the
terms and provisions of this Agreement shall be binding upon and inure to the
benefit of and be enforceable by Employee, the Corporation, the heirs and
personal representatives of Employee and the successors and assigns of the
Corporation.

      IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement
as of the day and year first above written.


                                        CADUS PHARMACEUTICAL CORPORATION


                                        By: __________________________________
                                            Jeremy M. Levin, President


                                        ______________________________________
                                        NAME OF EMPLOYEE


                                       8
<PAGE>

                                                                       EXHIBIT A

                               [Date of Exercise]

Cadus Pharmaceutical Corporation
777 Old Saw Mill River Road
Tarrytown, NY 10591-6705

Attention:  Corporate Secretary

           Re: Stock Option

Dear Sir:

            I am the holder of a Stock Option granted to me by Cadus
Pharmaceutical Corporation (the "Corporation"), pursuant to a Stock Option
Agreement dated as of December , 1995, to purchase shares of Common Stock of the
Corporation ("Shares"). I hereby exercise such option with respect to Shares,
the total purchase price for which is $ , and [I enclose a certified or bank
cashier's or other acceptable check payable to the order of the Corporation in
the amount of $ , representing the total purchase price for the Shares] [I
hereby elect to pay the purchase price by delivering to the Corporation shares
of Common Stock of the Corporation having a fair market value equal to $ from
the Shares I am purchasing pursuant to the exercise of such option]. The
certificate or certificates representing the Shares should be registered in my
name and should be forwarded to me at .

            Please acknowledge receipt of the exercise of my stock option on the
attached copy of this letter.

                                        Very truly yours,


                                        [EMPLOYEE]

RECEIPT ACKNOWLEDGED:

CADUS PHARMACEUTICAL CORPORATION


                                       9
<PAGE>

By: ______________________________


                                       10



                                                                     EXHIBIT 4.7

                             STOCK OPTION AGREEMENT

      AGREEMENT made as of November 15, 1996 by and between CADUS PHARMACEUTICAL
CORPORATION (the "Corporation"), a Delaware corporation having offices at 777
Old Saw Mill River Road, Tarrytown, New York 10591-8705, and
_____________________ ("Director"), residing at _____________________________.

                              W I T N E S S E T H:

      WHEREAS, Director desires to participate in the equity ownership of the
Corporation and the Corporation desires to provide Director with an incentive to
remain a director of the Corporation by granting to Director the right and
option, subject to certain conditions, to purchase shares of the common stock,
$.01 par value, of the Corporation (the "Common Stock");

      NOW, THEREFORE, in consideration of the mutual covenants hereinafter
contained, the parties hereto agree as follows:

      1. Grant of Stock Option.

            As an inducement to Director to continue to serve as a director of
the Corporation, the Corporation hereby grants to Director the right and option
(the "Option") to purchase from the Corporation Twelve Thousand (12,000) shares
of Common Stock (the "Shares"), subject to adjustment as provided in Paragraph 7
hereof, on the terms and subject to the conditions hereinafter set forth.

      2. Purchase Price.

            Subject to adjustment as provided in Paragraph 7 hereof, the
purchase price (the "Option Purchase Price") to be paid upon exercise of the
Option shall be $6.75 per share.

      3. Exercisability of Option.

            (a) The Option shall be exercisable, on a cumulative basis, during a
period of ten (10) years commencing from the date hereof and terminating at the
close of business on November 14, 2006, as follows:

<PAGE>

                  (i) up to 3,000 Shares subject to the Option may be purchased
by Director after November 15, 1997;

                  (ii) up to an additional 3,000 Shares subject to the Option
may be purchased by Director after November 15, 1998;

                  (iii) up to an additional 3,000 Shares subject to the Option
may be purchased by Director after November 15, 1999; and

                  (iv) up to an additional 3,000 Shares subject to the Option
may be purchased by Director after November 15, 2000.

            (b) The unexercised portion of the Option will automatically and
without notice terminate and become null and void at the close of business on
November 14, 2006. If, however, Director ceases to serve as a director of the
Corporation before the close of business on November 14, 2006, the Option will
terminate on the applicable date as described below; provided, however, that the
Compensation Committee of the Board of Directors shall have the authority to
accelerate the vesting schedule and/or extend the termination date and the time
for exercise of all or any part of the Option in any such event; and provided
further that none of the events described below shall extend the period of
exercisability of the Option beyond the close of business on November 14, 2006:

                  (i) the date Director ceases serving as a director of the
Corporation, if Director resigns or otherwise voluntarily ceases serving as a
director of the Corporation or if Director is removed as a director of the
Corporation for "cause" (as hereinafter defined);

                  (ii) the expiration of five (5) years after Director's death
or his ceasing to serve as a director of the Corporation by reason of his
"disability" (as hereinafter defined); or

                  (iii) the expiration of four (4) years from the date Director
involuntarily ceases serving as a director of the Corporation by reason of his
not being re-elected at an annual meeting of stockholders of the Corporation or
the date Director is removed as a director of the Corporation without "cause".

            (c) For the purposes of this Agreement, the term "cause" shall mean
the commission by Director of any material act of malfeasance, fraud,
dishonesty, or breach of fiduciary duty against the Corporation or any
unauthorized disclosure of confidential information by Director. The
determination of cause by the Board of Directors of the Corporation shall be
final and binding for all purposes.


                                       2
<PAGE>

            (d) For purposes of this Agreement, the term "disability" shall mean
such physical or mental illness or incapacity or Director as shall (i) prevent
Director from serving as a director of the Corporation and (ii) continue during
any period of one hundred twenty (120) consecutive days or for periods
aggregating one hundred eighty (180) days in any 365 day period.

      4. Exercise of Option.

            (a) The Option may be exercised by Director as to all or a portion
of the Shares (but not as to a fractional share of Common Stock) as to which the
Option has become exercisable, at any time within the applicable period
specified in Paragraph 3 hereof, by the giving of written notice of the exercise
thereof to the Corporation in the manner provided in Paragraph 14 hereof and
substantially in the form annexed hereto as Exhibit A, which notice shall be
accompanied by payment in full of the purchase price therefor by certified or
bank cashier's or other acceptable check. Such exercise shall be effective upon
receipt by the Corporation of such written notice and payment; and Director, to
the extent permitted by law, shall be deemed the owner of the Shares being
purchased as of the close of business on the date of such exercise and payment.
The Corporation shall cause a certificate or certificates representing the
Shares purchased to be delivered to Director within ten (10) days after the
effective date of such exercise. Director agrees that such certificate or
certificates shall bear such legend or legends as the Board of Directors of the
Corporation, in its sole discretion, determines to be necessary or appropriate
to prevent a violation of, or to perfect an exemption from, the registration
requirements of the Securities Act of 1933, as amended (the "Securities Act").

            (b) In lieu of the check provided for in subparagraph 4(a) above,
Director may, at his sole option and to the extent permitted by applicable law,
pay for the purchase price of the Shares being purchased by the exercise of the
Option, by delivering to the Corporation shares of Common Stock (in proper form
for transfer and accompanied by all requisite stock transfer tax stamps or cash
in lieu thereof) owned by Director having a Fair Market Value (as hereinafter
defined in subparagraph 4(c) hereof) equal to such purchase price. Director may
elect to make such delivery to the Corporation of shares of Common Stock from
Shares he is purchasing pursuant to his exercise of the Option by including such
election in his notice of exercise.

            (c) The Fair Market Value of a share of Common Stock as of a
particular date (the "Determination Date") shall mean:

                  (i) If the Corporation's Common Stock is traded on an exchange
or is quoted through the National Association of Securities Dealers, Inc.
Automated Quotation ("NASDAQ") National Market System, then the closing or last
sale price, respectively, reported for the last business day immediately
preceding the Determination Date.


                                       3
<PAGE>

                  (ii) If the Corporation's Common Stock is not listed on an
exchange or quoted on the NASDAQ National Market System but is traded in the
over-the-counter market, then the mean of the closing bid and asked prices
reported for the last business day immediately preceding the Determination Date.

                  (iii) Except as provided in subparagraph 4(c)(iv) below, if
the Corporation's Common Stock is not publicly traded, then as determined in
good faith by the Corporation's Board of Directors upon a review of relevant
factors.

                  (iv) If the Determination Date is the date of a liquidation,
dissolution or winding up of the Corporation, then all amounts to be payable per
share to holders of the Common Stock in the event of such liquidation,
dissolution or winding up.

      5. Purchase for Investment.

            Director agrees that at the request of the Corporation and upon
exercise of the Option, he shall execute and deliver to the Corporation a
written statement, in form satisfactory to the Corporation, representing and
warranting that he is purchasing the Shares for his own account, for investment
only and not with a view to the resale or distribution thereof and that any
subsequent offer for sale or sale of any of such Shares shall be made either
pursuant to (a) a registration statement on an appropriate form under the
Securities Act, which registration statement has become effective and is current
with respect to the shares being offered and sold, or (b) a specific exemption
from the registration requirements of the Securities Act, but in claiming such
exemption Director shall, prior to any offer for sale or sale of such shares,
obtain a favorable written opinion from counsel for or approved by the
Corporation as to the availability of such exemption.

      6. Non-Transferability of Option.

            The Option shall not be transferable by Director other than by will
or the laws of descent and distribution.

      7. Adjustment of Shares.

            If any change is made in the Shares deliverable upon exercise of the
Option (through merger, consolidation, reorganization, recapitalization, stock
dividend, stock split, split-up, spin-off, split-off, subdivision or combination
of shares, exchange of shares, issuance of rights to subscribe, change in
capital structure or similar event), such adjustments or substitutions shall be
made by the Board of Directors of the Corporation in or for the Shares
(including adjustments in the number of Shares and in the per share price of
Shares subject to the Option) as the Board of Directors of the Corporation
reasonably shall determine to be appropriate and equitable to prevent dilution
or enlargement of Director's rights hereunder.


                                       4
<PAGE>

      8. Covenants of the Corporation.

            The Corporation hereby covenants and agrees that:

            (a) During the period within which the Option may be exercised, the
Corporation shall at all times reserve and keep available by all necessary
corporate action out of its shares of Common Stock for the purpose of issuance
or transfer upon exercise of the Option the number of shares of Common Stock
included in the Shares and such additional securities as may from time to time
be deliverable hereunder. Such shares may be authorized but unissued shares, or
may be shares held in the treasury of the Corporation or a combination thereof,
at the option of the Corporation.

            (b) All shares which may be issued upon exercise of the Option or
delivered pursuant to this Agreement will, upon issuance and payment therefor as
provided herein, be validly issued, fully paid, nonassessable and free from all
liens and charges with respect to the issue thereof.

      9. Representations and Warranties of the Corporation.

            The Corporation represents and warrants to Director as follows:

                  (a) The Corporation is a corporation duly organized, validly
existing and in good standing under the laws of the State of Delaware.

                  (b) The Corporation has all requisite legal and corporate
power to execute this Agreement. The execution, delivery and performance by the
Corporation of this Agreement and the consummation of the transactions
contemplated hereby have been authorized by all necessary corporate action on
the part of the Corporation.

                  (c) This Agreement has been duly executed by the Corporation
and, assuming due and valid execution and delivery of the same by Director,
constitutes the valid and legally binding obligation of the Corporation
enforceable in accordance with its terms.

      10. No Fractional Shares.

            Upon the exercise of the Option, the Corporation shall not be
required to issue any fractional shares or scrip certificates evidencing any
fractional interest in shares. In any case where, pursuant to the terms of the
Option, Director would be entitled, except for the provisions of this Paragraph
10, to receive a fractional share, the number of shares issuable upon such
exercise shall be rounded to the next larger whole share if


                                       5
<PAGE>

such fractional share interest is a major fraction; if such fractional share
interest is not a major fraction, it shall be disregarded.

      11. "Lock-Up" Agreement.

            Director, if so requested by the Corporation and an underwriter of
Common Stock or other securities of the Corporation, shall not sell, grant any
option or right to buy or sell, or otherwise transfer or dispose of in any
manner, whether in privately-negotiated or open-market transactions, any Shares
held by him or which he has the right to acquire during the 180-day period
following the effective date of a registration statement of the Corporation
filed with the Securities and Exchange Commission in connection with such
offering or such shorter period as such underwriter shall have advised the
Corporation in writing is adequate to permit the successful and orderly
distribution of the Common Stock or such other securities; provided, however,
that such "lock-up" agreement shall be in writing and in form and substance
satisfactory to the Corporation and such underwriter. The Corporation may impose
stop-transfer instructions with respect to the Shares subject to the foregoing
restrictions until the end of said 180-day period. This Paragraph 11 shall
survive the termination or exercise of the Option.

      12. Entire Agreement Amendments.

            This Agreement sets forth the entire understanding of the parties
with respect to the subject matter hereof, and no statement, representation,
warranty or covenant has been made by either party except as expressly set forth
herein. This Agreement supersedes and cancels all prior agreements between the
parties, whether written or oral, with respect to the subject matter hereof. No
alteration, amendment or modification of any of the terms and provisions hereof
shall be valid unless made pursuant to a written instrument signed by all of the
parties hereto.

      13. Applicable Law.

            This Agreement shall be governed by, and construed and enforced in
accordance with, the laws of the State of Delaware.

      14. Notices.

            All notices, requests, demands and other communications hereunder
shall be in writing and shall be deemed to have been duly given if delivered
personally or mailed, first class, postage prepaid, certified mail, return
receipt requested, to the other party at its address as set forth at the
beginning of this Agreement or as either of the parties may designate in
conformity with the foregoing.


                                       6
<PAGE>

      15. Paragraph Headings.

            The paragraph headings set forth in this Agreement are for reference
purposes only and shall not be considered as part of this Agreement in any
respect nor shall they in any way affect the substance of any provisions
contained in this Agreement.

      16. Successors and Assigns.

            This Agreement shall not be assignable by Director, but the rights
hereunder may be transferred as described in Paragraph 6 hereof. All of the
terms and provisions of this Agreement shall be binding upon and inure to the
benefit of and be enforceable by Director, the Corporation, the heirs and
personal representatives of Director and the successors and assigns of the
Corporation.

      IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement
as of the date first above written.

                                   CADUS PHARMACEUTICAL CORPORATION


                                   By: ________________________________
                                       Jeremy M. Levin, President


                                   _________________________________
                                   [Director]


                                       7
<PAGE>

                                                                       EXHIBIT A

                               [Date of Exercise]

Cadus Pharmaceutical Corporation
777 Old Saw Mill River Road
Tarrytown, NY 10591-6705

Attention:  Corporate Secretary

         Re: Stock Option

Dear Sir:

            I am the holder of a Stock Option granted to me by Cadus
Pharmaceutical Corporation (the "Corporation"), pursuant to a Stock Option
Agreement dated as of November 15, 1996, to purchase 12,000 shares of Common
Stock of the Corporation ("Shares"). I hereby exercise such option with respect
to __________ Shares, the total purchase price for which is $_________, and [I
enclose a certified or bank cashier's or other acceptable check payable to the
order of the Corporation in the amount of $______________, representing the
total purchase price for the Shares] [I hereby elect to pay the purchase price
by delivering to the Corporation __________ shares of Common Stock of the
Corporation having a fair market value equal to $__________ from the Shares I am
purchasing pursuant to the exercise of such option]. The certificate or
certificates representing the Shares should be registered in my name and should
be forwarded to me at ___________________________________.

            Please acknowledge receipt of the exercise of my stock option on the
attached copy of this letter.

                                        Very truly yours,


                                        [Director]

RECEIPT ACKNOWLEDGED:

CADUS PHARMACEUTICAL CORPORATION


By: ________________________________



                                                                     EXHIBIT 4.9

                              AMENDED AND RESTATED

                          CERTIFICATE OF INCORPORATION

                                       OF

                        CADUS PHARMACEUTICAL CORPORATION
                       (formerly Cadus Therapeutics Corp.)

      CADUS PHARMACEUTICAL CORPORATION, a Delaware corporation (the
"Corporation"), hereby certifies as follows:

      1. The name of the Corporation is CADUS PHARMACEUTICAL CORPORATION.

      2. The Corporation's original Certificate of Incorporation was filed with
the Secretary of State of the State of Delaware on January 23, 1992, under the
name Cadus Therapeutics Corp.

      3. This Restated Certificate of Incorporation (the "Restated Certificate")
which was duly adopted in accordance with Sections 242 and 245, with prompt
written notice thereof having been given to the stockholders of the Corporation
pursuant to Section 228(d), of the General Corporation Law of the State of
Delaware, amends and restates the provisions of the present certificate of
incorporation, as amended, of the Corporation.

      4. Immediately upon filing this Restated Certificate, the text of the
present certificate of incorporation, as amended, is hereby amended and restated
to read in full as set forth herein:

      FIRST: The name of the Corporation is CADUS PHARMACEUTICAL CORPORATION
(the "Corporation").

      SECOND: The address of the Corporation's registered office in the State of
Delaware is 1209 Orange Street in the City of Wilmington, County of New Castle.
The name of its registered agent at such address is The Corporation Trust
Company.

      THIRD: The purpose of the Corporation is to engage in any lawful act or
activity for which corporations may be organized under the General Corporation
Law of the State of Delaware.

<PAGE>

      FOURTH: The total number of shares of capital stock which the Corporation
shall have authority to issue is 35,000,000, all of which shall be Common Stock
having a par value of $.01 per share.

      FIFTH: The Board of Directors of the Corporation is expressly authorized
and empowered to adopt, amend or repeal the by-laws of the Corporation, without
any action on the part of the stockholders of the Corporation, but the
stockholders of the Corporation may make additional by-laws and may amend or
repeal any by-law whether adopted by them or otherwise.

      SIXTH: Whenever a compromise or arrangement is proposed between this
Corporation and its creditors or any class of them and/or between this
Corporation and its stockholders or any class of them, any court of equitable
jurisdiction within the State of Delaware may, on the application in a summary
way of this Corporation or of any creditor or stockholder thereof or on the
application of any receiver or receivers appointed for this Corporation under
the provisions of Section 291 of Title 8 of the Delaware Code or on the
application of trustees in dissolution or of any receiver or receivers appointed
for this Corporation under the provisions of Section 279 of Title 8 of the
Delaware Code, order a meeting of the creditors or class of creditors, and/or of
the stockholders or class of stockholders of this Corporation, as the case may
be, to be summoned in such manner as the said court directs. If a majority in
number representing three-fourths in value of the creditors or class of
creditors, and/or of the stockholders or class of stockholders of this
Corporation, as the case may be, agree to any compromise or arrangement and to
any reorganization of this Corporation as consequence of such compromise or
arrangement, the said compromise or arrangement and the said reorganization
shall, if sanctioned by the court to which the said application has been made,
be binding on all the creditors or class of creditors, and/or all the
stockholders or class of stockholders, of this Corporation, as the case may be,
and also on this Corporation.

      SEVENTH: The personal liability of the directors of the Corporation is
hereby eliminated to the fullest extent permitted by subsection 102(b)(7) of the
General Corporation Law of the State of Delaware as the same may be amended and
supplemented.

      EIGHTH: The Corporation shall, to the fullest extent permitted by Section
145 of the General Corporation Law of the State of Delaware, as the same may be
amended and supplemented, indemnify any and all persons whom it shall have power
to indemnify under said section from and against any and all of the expenses,


<PAGE>

Liabilities, or other matters referred to in or covered by said section, and the
indemnification provided for herein shall not be deemed exclusive of any other
rights to which those indemnified may be entitled under any by-law, agreement,
vote of stockholders or disinterested directors or otherwise, both as to action
in his official capacity and as to action in another capacity while holding such
office, and shall continue as to a person who has ceased to be a director,
officer, employee, or agent and shall inure to the benefit of the heirs,
executors, and administrators of such a person. The Corporation shall advance
expenses for the defense of any director, officer, employee or agent prior to a
final disposition of a claim provided such party executes an undertaking to
repay advances from the Corporation if it is ultimately determined that such
party is not entitled to indemnification. Any repeal or modification of this
Article shall not adversely affect any right or protection existing hereunder
immediately prior to such repeal or modification.

      IN WITNESS WHEREOF, the Corporation has caused this Amended and Restated
Certificate of Incorporation to be signed by Jeremy M. Levin, its President, and
attested by James S. Rielly, its Secretary, on July 18, 1996.

                                             CADUS PHARMACEUTICAL CORPORATION


                                             By: s/ Jeremy M. Levin
                                                 -------------------------
                                                 Jeremy M. Levin
                                                 President

Attest:


s/ James S. Rielly
- -------------------------
James S. Rielly
Secretary



             [Letterhead of Morrison Cohen Singer & Weinstein, LLP]

                               February 14, 1997



Cadus Pharmaceutical Corporation
777 Old Saw Mill River Road
Tarrytown, New York 10591

     Re:  Cadus Pharmaceutical Corporation
          Registration Statement on Form S-8

Gentlemen:

      We have acted as counsel to Cadus Pharmaceutical Corporation, a Delaware
corporation (the "Company"), in connection with the preparation of a
Registration Statement on Form S-8 (the "Registration Statement") being filed by
the Company with the Securities and Exchange Commission under the Securities Act
of 1933, as amended, covering an aggregate of 2,162,415 shares (the "Shares") of
common stock of the Company, $.01 par value per share (the "Common Stock"),
issuable upon the exercise of certain stock options (the "Options").

      In so acting, we have examined copies of such records of the Company and
such other certificates and documents as we have deemed relevant and necessary
for the opinion hereinafter set forth. In such examination, we have assumed the
genuineness of all signatures, the authenticity of all documents submitted to us
as originals and the conformity to authentic originals of all documents
submitted to us as certified or reproduced copies. We have also assumed the
legal capacities of all persons executing such documents and the truth and
correctness of any representations or warranties contained therein. As to
various questions of fact material to such opinion, we have relied upon
certificates of officers of the Company.

      Based upon and subject to the foregoing, we are of the opinion that the
Shares issuable upon exercise of the Options, when paid for and issued in
accordance with the terms of the Options, will be validly issued and fully paid
and nonassessable.


<PAGE>

February 14, 1997
Page 2

      We hereby consent to your filing copies of this opinion as an exhibit to
the Registration Statement or any amendment thereto.

                                  Very truly yours,

                                  /s/ Morrison Cohen Singer & Weinstein, LLP

                                  MORRISON COHEN SINGER & WEINSTEIN, LLP


                                                                    EXHIBIT 23.1

                          INDEPENDENT AUDITORS' CONSENT

The Board of Directors 
Cadus Pharmaceutical Corporation:

We consent to the use of our report incorporated herein by reference.

                                             S/KPMG Peat Marwick LLP


New York, New York
February 14, 1997



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