PALATIN TECHNOLOGIES INC
S-8, 1998-06-17
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
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                                                     Registration No. 333-______
================================================================================

                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                          -----------------------------

                                    FORM S-8
             REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933

                          -----------------------------

                           PALATIN TECHNOLOGIES, INC.
             (Exact name of registrant as specified in its charter)

               DELAWARE                                  95-4078884
(State of incorporation or organization)    (I.R.S. Employer Identification No.)

                         214 CARNEGIE CENTER, SUITE 100
                           PRINCETON, NEW JERSEY 08540
               (Address of principal executive offices) (Zip Code)

          RHOMED INCORPORATED 1987 EMPLOYEE INCENTIVE STOCK OPTION PLAN
             RHOMED INCORPORATED 1987 NONQUALIFIED STOCK OPTION PLAN
          RHOMED INCORPORATED 1995 EMPLOYEE INCENTIVE STOCK OPTION PLAN
             RHOMED INCORPORATED 1995 NONQUALIFIED STOCK OPTION PLAN
                PALATIN TECHNOLOGIES, INC. 1996 STOCK OPTION PLAN
                      EDWARD J. QUILTY EMPLOYMENT AGREEMENT
                        CARL SPANA STOCK OPTION AGREEMENT
                    CHARLES L. PUTNAM STOCK OPTION AGREEMENT
                    RICHARD J. MURPHY STOCK OPTION AGREEMENT
                 1997 EXECUTIVE OFFICERS STOCK OPTION AGREEMENT
                           (Full titles of the plans)

                        STEPHEN T. WILLS, VICE PRESIDENT
           PALATIN TECHNOLOGIES, INC., 214 CARNEGIE CENTER, SUITE 100,
                               PRINCETON, NJ 08540
                    (Name and address of agent for service)

                                 (609) 520-1911
          (Telephone number, including area code, of agent for service)

                  Please send copies of all communications to:

                             Faith L. Charles, Esq.
                      Rubin Baum Levin Constant & Friedman
              30 Rockefeller Plaza, 29th Floor, New York, NY 10112
                            Telephone: (212) 698-7700


<PAGE>


<TABLE>
<CAPTION>
                                CALCULATION OF REGISTRATION FEE
- - --------------------------------------------------------------------------------------------------------
                                                                   Proposed
     Title of                                Proposed              maximum
 securities to be     Amount to be       maximum offering     aggregate offering        Amount of
    registered         registered      price per share (1)        price (2)         registration fee
- - --------------------------------------------------------------------------------------------------------
<S>                     <C>                   <C>                <C>                    <C> 
   Common Stock         1,271,341             $21.70             $6,385,916.69          $1,883.85
</TABLE>
NOTES TO FEE TABLE:

(1)     The  proposed  maximum  offering  price per share is the actual  maximum
        offering price per share for any option currently  outstanding under any
        of the  plans.  The  offering  price per share is fixed for all  options
        under all plans except the Palatin Technologies,  Inc. 1996 Stock Option
        Plan (the "1996 Plan").  The proposed  maximum  offering price per share
        under the 1996  Plan,  calculated  pursuant  to Rules  457(c) and 457(h)
        under the  Securities  Act of 1993 and based on the  average of the high
        and low prices of the  registrant's  common stock reported on the Nasdaq
        SmallCap  Market on June 12,  1998,  is less than the  $21.70  per share
        maximum among the other plans.

(2)     The  proposed  maximum  aggregate  offering  price is the sum of (a) the
        actual maximum  aggregate  offering prices for all  outstanding  options
        ($5,704,798.96) plus (b) the proposed maximum  aggregate  offering price
        for  options  which  may be  granted  under  the 1996  Plan,  calculated
        pursuant to Rules 457(c) and 457(h) under the Securities Act of 1993 and
        based on the average of the high and low prices of Common Stock reported
        on the Nasdaq SmallCap Market on June 12, 1998 ($6.09).





<PAGE>



PART I.  INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

         The  information  required by Part I is included in  documents  sent or
given to  participants  in each of the plans  listed  on the cover  page of this
registration  statement  (this  "Registration  Statement"),   pursuant  to  Rule
428(b)(1) of the Securities Act of 1933, as amended (the "Securities Act").


PART II.  INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

ITEM 3. INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE. The following documents
are incorporated in this Registration Statement by reference:

          (a) The registrant's  latest annual report,  filed pursuant to Section
13(a) or 15(d) of the Securities Exchange Act of 1934, as amended (the "Exchange
Act"),  or the  latest  prospectus  filed  pursuant  to Rule  424(b)  under  the
Securities Act that contains audited  financial  statements for the registrant's
latest fiscal year for which such statements have been filed.

          (b) All other reports filed  pursuant to Section 13(a) or 15(d) of the
Exchange Act since the end of the fiscal year covered by the registrant document
referred to in (a) above.

          (c) The  description  of common stock  contained  in the  registrant's
Registration  Statement on Form 8-A filed under the Exchange Act,  including any
amendment or report filed for the purpose of updating such description.

All documents  subsequently filed by the registrant  pursuant to Sections 13(a),
13(c),   14,  and  15(d)  of  the  Exchange  Act,  prior  to  the  filing  of  a
post-effective amendment which indicates that all shares of common stock offered
hereby  have been sold or which  deregisters  all  shares of common  stock  then
remaining  unsold,  shall be  deemed to be  incorporated  by  reference  in this
Registration  Statement  and to be part  thereof  from the date of the filing of
such documents.

Any statement contained in a document  incorporated by reference herein shall be
deemed to be modified or superseded for purposes of this Registration  Statement
to the extent that a  statement  contained  herein or in any other  subsequently
filed  document  which also is  incorporated  herein  modifies or replaces  such
statement.  Any statement so modified or superseded shall not be deemed,  in its
unmodified form, to constitute a part of this Registration Statement.

ITEM 4. DESCRIPTION OF SECURITIES.

        Not applicable.



                                        1

<PAGE>



ITEM 5. INTERESTS OF NAMED EXPERTS AND COUNSEL.

        Certain legal matters relating to the issuance of shares of Common Stock
covered by this  Registration  Statement  will be passed upon for the Company by
Rubin  Baum  Levin  Constant  &  Friedman,  New York,  New York,  counsel to the
Company.  Members  of Rubin Baum Levin  Constant  & Friedman  have been  granted
options under the Palatin Technologies,  Inc. 1996 Stock Option Plan to purchase
an aggregate of 12,500 shares of Common Stock at an exercise  price of $8.00 per
share, and 5,000 shares of Common Stock at an exercise price of $6.00 per share.
The options are  immediately  exercisable  and will expire on dates ranging from
January 3, 2007 to January 21, 2008.


ITEM 6. INDEMNIFICATION OF DIRECTORS AND OFFICERS.

        Section 145 of the Delaware  General  Corporation  Law  provides  that a
corporation  may  indemnify any person who was or is a party or is threatened to
be  made a  party  to any  threatened,  pending  or  completed  action,  suit or
proceeding,  whether civil, criminal,  administrative or investigative by reason
of the fact  that he is or was a  director,  officer,  employee  or agent of the
corporation, or serving at the request of the corporation in similar capacities,
against expenses (including attorneys' fees), judgments, fines, and amounts paid
in settlement  actually and reasonably  incurred by him in connection  with such
action,  suit or  proceeding  if he  acted  in good  faith  and in a  manner  he
reasonably  believed  to be in or not  opposed  to  the  best  interests  of the
corporation,  and,  with respect to any criminal  action or  proceeding,  had no
reasonable  cause to believe his conduct was unlawful.  In the case of an action
or suit by or in the right of the corporation,  no indemnification shall be made
with  respect to any claim,  issue or matter as to which such person  shall have
been adjudged to be liable to the corporation unless and only to the extent that
the court having  jurisdiction  shall  determine  that such person is fairly and
reasonably entitled to indemnity.

        Article V, Section 3 of the  registrant's  Certificate of  Incorporation
provides  that  to  the  fullest  extent   permitted  by  the  Delaware  General
Corporation Law, no director of the registrant shall be personally liable to the
registrant or its  stockholders  for monetary  damages for breach of a fiduciary
duty as a director.

        Article VI of the  registrant's  Certificate of  Incorporation  provides
that the registrant shall make the  indemnification  permitted under Section 145
of the Delaware General  Corporation Law, as summarized  above, but only (unless
ordered  by a  court)  upon  a  determination  by a  majority  of  a  quorum  of
disinterested  directors,  by independent legal counsel in a written opinion, or
by the stockholders, that the indemnified person has met the applicable standard
of conduct. Article VI further provides that the regisefending actions, suits or
proceedings  upon  such  terms  and  conditions  as the  registrant's  Board  of
Directors deems  appropriate,  and that the registrant may purchase insurance on
behalf of

                                        2

<PAGE>



indemnified  persons  whether  or not the  registrant  would  have the  power to
indemnify such persons under Section 145 the Delaware General Corporation Law.

        The registrant's Bylaws contain  substantially the same  indemnification
provisions as the registrant's Certificate of Incorporation, summarized above.

        The Edward J. Quilty  Employment  Agreement  requires the  registrant to
indemnify and advance expenses to Edward J. Quilty, the registrant's Chairman of
the  Board,  President  and  Chief  Executive  Officer,  to the  fullest  extent
permitted under Section 145 of the Delaware General Corporation Law.

        The  registrant  has  obtained  a  directors'  and  officers'  liability
insurance policy which covers,  among other things,  certain liabilities arising
under the Securities Act.


ITEM 7. EXEMPTION FROM REGISTRATION CLAIMED.

        Not applicable.


ITEM 8.  EXHIBITS.  The  following  exhibits  are filed  with this  Registration
Statement, or incorporated by reference as noted:

4.1     Restated  Certificate of Incorporation of the registrant,  as filed with
        the  Delaware  Secretary of State on November 3, 1993;  incorporated  by
        reference  to Exhibit  3.1 of the  registrant's  Form 8-K dated July 19,
        1996,   filed  with  the   Securities  and  Exchange   Commission   (the
        "Commission") on August 9, 1996.

4.2     Amendment  to  the  Restated   Certificate  of   Incorporation   of  the
        registrant,  as filed with the  Delaware  Secretary of State on July 19,
        1996;  incorporated by reference to Exhibit 3.2 of the registrant's Form
        8-K dated July 19, 1996, filed with the Commission on August 9, 1996.

4.3     Certificate of Designation  of Series A Convertible  Preferred  Stock of
        the  registrant,  as  filed  with  the  Delaware  Secretary  of State on
        February  21,  1997;  incorporated  by  reference  to Exhibit 3.6 of the
        registrant's  Form  10-QSB/A  dated  March  31,  1997,  filed  with  the
        Commission on July 17, 1997.

4.4     Amendment  to  the  Restated   Certificate  of   Incorporation   of  the
        registrant,  as filed with the Delaware  Secretary of State on September
        5, 1997;  incorporated  by reference to Exhibit 3.7 of the  registrant's
        Form 10-KSB dated June 30, 1997,  filed with the Commission on September
        26, 1997.


                                        3

<PAGE>



4.5     Certificate of Designations  of Series B Convertible  Preferred Stock of
        the registrant,  as filed with the Delaware  Secretary of State on April
        27, 1998;  incorporated by reference to Exhibit 3.8 of the  registrant's
        Form 8-K dated April 28, 1998, filed with the Commission on May 8, 1998.

4.6     Bylaws of the  registrant;  incorporated  by reference to Exhibit 3.2 of
        the  registrant's  Form 10-QSB dated  December 31, 1997,  filed with the
        Commission on February 13, 1998.

4.7     Agreement and Plan of  Reorganization  dated as of April 12, 1996 by and
        between  Interfilm,   Inc.,  Interfilm   Acquisition  Corp.  and  RhoMed
        Incorporated;   incorporated   by   reference  to  Exhibit  2.1  of  the
        registrant's  Form 8-K dated June 25, 1996, filed with the Commission on
        July 10, 1996.

4.8     RhoMed Incorporated 1987 Employee Incentive Stock Option Plan.

4.9     RhoMed Incorporated 1987 Nonqualified Stock Option Plan.

4.10    RhoMed   Incorporated   1995  Employee   Incentive  Stock  Option  Plan;
        incorporated  by reference  to Exhibit  10.04 of the  registrant's  Form
        10-KSB dated June 30, 1996,  filed with the  Commission on September 30,
        1996.

4.11    RhoMed Incorporated 1995 Nonqualified Stock Option Plan; incorporated by
        reference to Exhibit  10.05 of the  registrant's  Form 10-KSB dated June
        30, 1996, filed with the Commission on September 30, 1996.

4.12    Palatin Technologies, Inc. 1996 Stock Option Plan.

4.13    Edward J. Quilty  Employment  Agreement  dated as of November  16, 1995;
        incorporated  by reference  to Exhibit  10.07 of the  registrant's  Form
        10-KSB dated June 30, 1996,  filed with the  Commission on September 30,
        1996.

4.14    Amendment to Edward J. Quilty Employment  Agreement dated as of November
        16, 1995; incorporated by reference to Exhibit 10.28 of the registrant's
        Form 10-KSB dated June 30, 1997,  filed with the Commission on September
        26, 1997.

4.15    Carl Spana Stock Option Agreement.

4.16    Charles L. Putnam Stock Option Agreement.

4.17    Richard J. Murphy Stock Option Agreement.

4.18    1997 Executive Officers Stock Option Agreement.

5.1     Opinion  of  Rubin  Baum  Levin  Constant &  Friedman,  counsel  to  the
        registrant.


                                        4

<PAGE>




23.1    Consent  of Rubin Baum Levin  Constant & Friedman  (included  in Exhibit
        5.1).

23.2    Consent of Arthur Andersen LLP.

24.1    Power of Attorney  (included on the signature page of this  Registration
        Statement).


ITEM 9.  UNDERTAKINGS.  The registrant will:

        (1) File,  during any period in which it offers or sells  securities,  a
post-effective amendment to this Registration Statement to:

               (i) include any  prospectus required by Section  10(a)(3) of  the
Securities Act;

               (ii)  reflect  in the  prospectus  any  facts  or  events  which,
individually or together,  represent a fundamental change in the information set
forth in the Registration Statement. Notwithstanding the foregoing, any increase
or  decrease  in volume of  securities  offered  (if the total  dollar  value of
securities offered would not exceed that which was registered) and any deviation
from  the  low or  high  end of the  estimated  maximum  offering  range  may be
reflected in the form of prospectus  filed with the Commission  pursuant to Rule
424(b) if, in the aggregate,  the changes in volume and price  represent no more
than a 20%  change  in the  maximum  aggregate  offering  price set forth in the
"Calculation of Registration Fee" table in the effective Registration Statement;
and

               (iii) include any additional or changed  material  information on
the plan of distribution;

provided,  however,  that  paragraphs  (1)(i) and (1)(ii)  will not apply if the
information  required  to be  included in a  post-effective  amendment  by those
paragraphs  is  contained  in periodic  reports  filed with or  furnished to the
Commission  by the  registrant  pursuant  to Section 13 or Section  15(d) of the
Exchange Act that are incorporated by reference in the Registration Statement.

        (2) For  determining  liability  under the  Securities  Act,  treat each
post-effective  amendment  as a new  registration  statement  of the  securities
offered, and the offering of such securities at that time to be the initial bona
fide offering thereof.

        (3) File a post-effective  amendment to remove from  registration any of
the securities that remain unsold at the end of the offering.

        The  undersigned  registrant  hereby  undertakes  that,  for purposes of
determining  any  liability  under  the  Securities  Act,  each  filing  of  the
registrant's  annual  report  pursuant to section  13(a) or section 15(d) of the
Exchange Act (and, where application,  each filing of an employee benefit plan's
annual  report   pursuant  to  section  15(d)  of  the  Exchange  Act)  that  is
incorporated by reference in the Registration  Statement shall be deemed to be a
new registration  statement relating to the securities offered therein,  and the
offering of such  securities at that time shall be deemed to be the initial bona
fide offering thereof.

        Insofar as indemnification  for liabilities arising under the Securities
Act may be  permitted to  directors,  officers  and  controlling  persons of the
registrant pursuant to the foregoing  provisions,  or otherwise,  the registrant
has been advised that in the opinion of the Commission such  indemnification  is
against  public  policy as expressed in the  Securities  Act and is,  therefore,
unenforceable.  In the  event  that a claim  for  indemnification  against  such
liabilities  (other than the payment by the  registrant of expenses  incurred or
paid by a  director,  officer or  controlling  person of the  registrant  in the
successful  defense of any  action,  suit or  proceeding)  is  asserted  by such
director,  officer or controlling person in connection with the securities being
registered, the registrant will, unless in the opinion of its counsel the matter
has been  settled by  controlling  precedent,  submit to a court of  appropriate
jurisdiction the question whether such  indemnification  by it is against public
policy as  expressed  in the  Securities  Act and will be  governed by the final
adjudication of such issue.




                                        5

<PAGE>



                                   SIGNATURES

        Pursuant to the  requirements  of the  Securities  Act,  the  registrant
certifies  that it has  reasonable  grounds to believe  that it meets all of the
requirements  for  filing  on Form S-8 and has  duly  caused  this  Registration
Statement  to be  signed  on its  behalf  by  the  undersigned,  thereunto  duly
authorized, in the City of Princeton, State of New Jersey, on June 17, 1998.

PALATIN TECHNOLOGIES, INC.


By:     /s/ Edward J. Quilty
        --------------------
        Edward J. Quilty
        Chairman of the Board, President and Chief Executive Officer


                                POWER OF ATTORNEY

        We, the  undersigned  officers and  directors  of Palatin  Technologies,
Inc.,  severally  constitute  Edward J.  Quilty and Stephen T. Wills and each of
them singly,  our true and lawful attorneys with full power to them, and each of
them singly, to sign for us and in our names in the capacities  indicated below,
the Registration Statement on Form S-8 filed herewith and any and all subsequent
amendments to said Registration  Statement,  and generally to do all such things
in our names and behalf in our  capacities  as officers and  directors to enable
Palatin Technologies, Inc. to comply with all requirements of the Commission.

        Pursuant to the  requirements of the Securities  Act, this  Registration
Statement has been signed below by the following  persons in the  capacities and
on the date indicated.


     SIGNATURE                          TITLES                          DATE


/s/ Edward J. Quilty
- - -----------------------  Chairman of the Board, President and      June 17, 1998
    Edward J. Quilty     Chief Executive Officer (principal
                         executive officer)


/s/ Carl Spana
- - -----------------------  Executive Vice President and Director     June 17, 1998
    Carl Spana



/s/ Stephen T. Wills
- - -----------------------  Vice President and Chief Financial        June 17, 1998
    Stephen T. Wills     Officer (principal financial and 
                         accounting officer)


/s/ Michael S. Weiss
- - -----------------------  Director                                  June 17, 1998
    Michael S. Weiss


                                        6

<PAGE>




/s/ James T. O'Brien
- - -----------------------  Director                                  June 17, 1998
    James T. O'Brien



/s/ John K.A. Prendergast
- - -----------------------  Director                                  June 17, 1998
    John K.A. Prendergast



/s/ Robert G. Moussa
- - -----------------------  Director                                  June 17, 1998
    Robert G. Moussa

 





                                        7

<PAGE>



                                INDEX TO EXHIBITS

Number                                 Description
- - ------                              -----------------
4.8            RhoMed Incorporated 1987 Employee Incentive Stock Option Plan.

4.9            RhoMed Incorporated 1987 Nonqualified Stock Option Plan.

4.12           Palatin Technologies, Inc. 1996 Stock Option Plan.

4.15           Carl Spana Stock Option Agreement.

4.16           Charles L. Putnam Stock Option Agreement.

4.17           Richard J. Murphy Stock Option Agreement.

4.18           1997 Executive Officers Stock Option Agreement.

5.1            Opinion of Rubin Baum Levin Constant & Friedman,  counsel to  the
               registrant.

23.2           Consent of Arthur Andersen LLP.




                                        8


                    1987 EMPLOYEE INCENTIVE STOCK OPTION PLAN

                               RHOMED INCORPORATED

Article 1  -  Purpose
        The  Employee  Incentive  Stock  Option  Plan (the  "Employee  Plan") is
intended to advance the interests of RhoMed Incorporated (the "Company") and its
shareholders  by providing an employment  incentive,  to retain in the employ of
the  Company  persons of  training,  experience,  and  ability,  to attract  new
employees  whose services are considered  unusually  valuable,  to encourage the
sense of proprietorship of such persons, and to stimulate the active interest of
such persons in the development and financial success of the Company.

Article 2  -  Definitions
        As used in this document,  the following  terms have the meanings stated
unless the context clearly indicates to the contrary:
        2.1  "Board"  shall  mean the Board of  Directors  of the  Company.  2.2
"Committee" shall mean the body  administering the Employee Plan, which shall be
the Compensation  Committee of the Board,  and if no Compensation  Committee has
been established, it shall mean the Board.
        2.3 "Company" shall mean RhoMed Incorporated.
        2.4 "Option" shall mean an option to purchase Stock granted  pursuant to
the provisions of this Employee Plan.
        2.5 "Optionee" shall mean an employee to whom an Option has been granted
under this Employee Plan.
        2.6  "Employee  Plan" shall mean this  Employee  Incentive  Stock Option
Plan, the terms of which are set forth herein.
        2.7 "Stock" shall mean the Common Stock of the Company.
        2.8 "Stock  Option  Agreement"  shall  mean the  agreement  between  the
Company and an employee pursuant to the Employee Plan.
        2.9 "Eligible Employee" shall mean any full time employee of the Company
as defined by the Company's personnel policies.

Article 3 - Administration of Employee Plan
        The  Employee  Plan  shall  be  administered  by  the  Board  or by  the
Committee,  being a committee  appointed by the Board.  If the Employee  Plan is
administered  by the  Committee,  it shall  report all action taken by it to the
Board.  The  Committee  shall have full and final  authority in its  discretion,
subject to the provisions of the Employee Plan, to determine the  individuals to
whom and the time or times at which  options  shall be granted and the number of
shares and purchase  price of Common Stock  covered by each option;  to construe
and  interpret the Employee  Plan; to determine the terms and  provisions of the
Stock Option  Agreements,  which need not be identical,  including,  but without
limitation,  terms  covering  the payment of the option  price;  and to make all
other  determinations  and take all other actions deemed  necessary or advisable
for the

                                     Page 1

<PAGE>



proper  administration of the plan. All such actions and determinations shall be
conclusively binding for all purposes and upon all persons.

Article 4  -  Grant of Options
        The  Committee is hereby  authorized  by majority vote of its members to
issue  Options  from  time to time on the  Company's  behalf  to any one or more
persons who at the date of such grant are  full-time  employees  of the Company.
Any Option  granted under this  Employee Plan shall be granted  within ten years
from the date hereof.

Article 5  -  Amount of Stock
        The aggregate amount of Stock which may be purchased pursuant to options
granted under this Employee Plan shall be 750,000 shares of the Company's Stock,
which is Common Stock, no par value.

Article 6  -  Limitation
        Options  shall not be granted  under this  Employee  Plan,  which  first
become  exercisable  in any  calendar  year and which  permit  the  optionee  to
purchase Stock of the Company having an aggregate value in excess of one hundred
thousand dollars ($100,000), determined at the time of the grant of the Options.
No optionee  may  exercise  options  during a calendar  year for the purchase of
shares  having an  aggregate  fair market value  (determined  at the time of the
grant of the options) exceeding one hundred thousand dollars ($100,000),  except
and to the extent that such options were first exercisable in preceding calendar
years.

Article 7  -  Nontransferability
        The terms of any Option granted under this Employee Plan shall include a
provision making such Option nontransferable by the Optionee, except upon death,
and exercisable during the Optionee's lifetime only by the Optionee.

Article 8  -  Terms and Conditions of Options
        Any  Option  granted  pursuant  to  this  Employee  Plan  shall  contain
provisions,  established by the Committee,  setting forth the manner of exercise
of such Option. Such Stock Option Agreement shall be in writing, executed by the
Company and the  applicable  officer or independent  contractor,  and be in such
form as the Committee  may from time to time  approve,  subject to the following
limitations and conditions:
        8.1 Option Price. The purchase price for a share of the Stock subject to
any Option granted hereunder shall be not less than the fair market value of the
Stock on the date of the  grant of the  Option,  said  fair  market  value to be
determined  in good faith at the time of grant of such Option by decision of the
Committee;  provided,  however,  that in the case of an  Option  granted  to any
person  then  owning  more than ten  percent  (10%) of the  voting  power of all
classes  of the  Company's  stock,  the  purchase  price  per share of the stock
subject to Option  shall be not less than one hundred ten percent  (110%) of the
fair market value of the stock on the date of grant of the Option, determined in
good faith as aforesaid.

                                     Page 2

<PAGE>



        8.2 Period of Option.  The expiration date of each option shall be fixed
by the Committee, but, notwithstanding any provision of the Employee Plan to the
contrary, such expiration date shall not be more than ten years from the date of
grant.  In no event,  however,  shall any Option granted to a person then owning
more than ten percent  (10%) of the voting power of all classes of the Company's
Stock be  exercisable  by its terms after the  expiration of five years from the
date of the grant thereof.
        8.3 Vesting of Shareholder Rights. Neither an optionee nor his successor
shall  have  any  of the  rights  of a  shareholder  of the  Company  until  the
certificates  evidencing  the shares  purchased  are properly  delivered to such
optionee or his successor.
        8.4 Exercise of Option.  An option shall not be  exercisable in whole or
in part prior to the date of shareholder approval of the Plan.
        8.5  Nontransferability  of Option.  No option shall be  transferable or
assignable  by an  optionee,  otherwise  than by will or the laws of descent and
distribution  and  each  option  shall be  exercisable,  during  the  optionee's
lifetime, only by him. No option shall be pledged or hypothecated in any way and
no option shall be subject to execution,  attachment,  or similar process except
with the express consent of the Committee.
        8.6  Limitations on Exercise of Option Rights.  The optionee must remain
in the  continuous  employment  of the  Company  for one year  from the date the
option is granted before any part thereof or right  thereunder may be exercised.
Thereafter,  the  option  may  be  exercisable  in  whole  or  installments,  as
determined by the Committee at the time the option is granted.
        8.7   Termination  of  Employment  or  Contractual   Arrangement.   Upon
termination  of an  optionee's  employment  with the  Company or with any of its
subsidiaries  (except if such termination be by reason of death or permanent and
total  disability),  his option  privileges shall be limited to the shares which
were  immediately  purchasable  by him at the  date  of  such  termination.  The
granting  of an  option  to an  eligible  person  does not  alter in any way the
Company's existing rights to terminate such person's  employment at any time for
any reason,  nor does it confer upon such person any rights or privileges except
as specifically provided for in the Employee Plan.
        8.8 Termination by Permanent and Total  Disability.  Upon termination of
an optionee's  employment  with the Company or with any of its  subsidiaries  by
reason of permanent and total disability, his option privileges shall be limited
to the shares  which  were  immediately  purchasable  by him at the date of such
termination.
        8.9 Death of  Optionee.  If an optionee  dies while in the employ of the
Company,  his  option  privileges  shall be  limited  to the  shares  which were
immediately purchasable by him at the date of death.

Article 9  -  Adjustments
        9.1 In the event  that the  outstanding  shares  of Common  Stock of the
Company are hereafter  increased or decreased or changed into or exchanged for a
different  number or kind of shares or other  securities  of the  Company  or of
another corporation,  by reason of a recapitalization,  reclassification,  stock
split-up,  combination  of shares or dividend or other  distribution  payable in
capital  stock,  appropriate  adjustment  shall be made by the  Committee in the
number and kind of shares for the purchase of which options may be granted under
the Plan. In addition,  the Committee shall make  appropriate  adjustment in the
number and kind of shares

                                     Page 3

<PAGE>



as to which outstanding options, or portions thereof then unexercised,  shall be
exercisable,  to the end that the  proportionate  interest  of the holder of the
option shall, to the extent practicable,  be maintained as before the occurrence
of such event.  Such  adjustment  in  outstanding  options shall be made without
change in the total price  applicable to the  unexercised  portion of the option
but with a corresponding adjustment in the option price per share.
        9.2 In the event of the  dissolution or liquidation of the Company,  any
option granted under the Employee Plan shall  terminate as of a date to be fixed
by the  Committee,  provided that not less than 30 days'  written  notice of the
date so fixed shall be given to each optionee and each  optionee  shall have the
right  during such  period to  exercise  his option as to all or any part of the
shares  covered  thereby  including  shares as to which  such  option  would not
otherwise be exercisable by reason of an insufficient lapse of time.
        9.3 In the event of a Reorganization (as hereafter defined) in which the
Company is not the surviving or acquiring company, or in which the Company is or
becomes a wholly owned subsidiary of another company after the effective date of
the Reorganization, then:
               9.3.1  If  there  is  no  plan  or   agreement   respecting   the
Reorganization  ("Reorganization  Agreement") or if the Reorganization Agreement
does not  specifically  provide  for the change,  conversion  or exchange of the
shares under outstanding and unexercised stock options for securities of another
corporation,  then the Committee  shall take such action,  and the options shall
terminate, as provided in Article 9.2; or
               9.3.2  If  there  is  a  Reorganization   Agreement  and  if  the
Reorganization  Agreement specifically provides for the change,  conversion,  or
exchange of the shares  under  outstanding  and  unexercised  stock  options for
securities of another  corporation,  then the Committee  shall adjust the shares
under such  outstanding  and  unexercised  stock  options  (and shall adjust the
shares remaining under the Employee Plan which are then available to be optioned
under  the  Employee  Plan,  if  the  Reorganization  Agreement  makes  specific
provision  therefor) in an manner not  inconsistent  with the  provisions of the
Reorganization  Agreement for the adjust change,  conversion or exchange of such
stock and such options.
               9.3.3 The term  "Reorganization"  as used in Article  9.3 and its
subparts shall mean any statutory merger, statutory  consolidation,  sale of all
or  substantially  all of the assets of the  Company,  or sale,  pursuant  to an
agreement with the Company,  of securities of the Company  pursuant to which the
Company is or becomes a wholly owned  subsidiary  of another  company  after the
effective date of the Reorganization.
        9.4 Adjusts and  determinations  made under this Article 9 shall be made
by the Committee, whose decisions as to what adjustments or determinations shall
be made, and the extent thereof, shall be final, binding and conclusive.

Article 10  -  Restrictions on Issuing Shares
        The exercise of each option shall be subject to the condition that if at
any time the Company shall determine in its discretion that the  satisfaction of
withholding  tax  or  other  withholding  liabilities,   or  that  the  listing,
registration,  or qualification  of any shares  otherwise  deliverable upon such
such exercise upon any securities exchange or under any state or federal law, or
that the consent or approval of any  regulatory  body, is necessary or desirable
as a condition  of, or in  connection  with,  such  exercise or the  delivery or
purchase of shares pursuant

                                     Page 4

<PAGE>



thereto,  then in any such event,  such exercise  shall not be effective  unless
such withholding,  listing,  registration,  qualification,  consent, or approval
shall have been effected or obtained free of any  conditions  not  acceptable to
the Company.  The Committee may also impose such restrictions on any shares sold
pursuant to this  Employee  Plan as it may deem  advisable,  including,  without
limitation, restrictions under the Securities Act of 1933, as amended, under the
requirements  of any stock exchange upon which such shares or shares of the same
class are then listed,  and under any blue sky or securities  laws applicable to
such shares.

Article 11 - Amendment,  Suspension,  or  Termination  of Employee Plan 11.1 The
        Board may at any time suspend or terminate the Employee Plan or may
amend it from time to time in such  respects as the Board may deem  advisable in
order that the options granted  thereunder may conform to any changes in the law
or in any other respect which the Board may deem to be in the best  interests of
the Company; provided, however, that without approval by the shareholders of the
Company representing a majority of the voting power, no such amendment shall:
               11.1.1  Except as  specified  in Article 9,  increase the maximum
number of shares for which options may be granted under the Employee Plan;
               11.1.2  Change the  provisions  of Article  8.1  relating to  the
establishment of the option price;
               11.1.3  Change the  provisions  of Article  8.2  relating  to the
expiration date of each option; or,
               11.1.4  Change the  provisions  of  Article 11 and its  subparts,
relating to amendment, suspension and termination of the Employee Plan.
        11.2 Unless the Employee Plan shall  theretofore have been terminated by
the Board or as provided in Article 14, the Employee  Plan shall  terminate  ten
years after the  effective  date of the Employee  Plan. No option may be granted
during any  suspension  or after  termination  of the Employee  Plan.  Except as
provided in Article 14, no amendment, suspension, or termination of the Employee
Plan shall, without an optionee's consent,  alter or impair any of the rights or
obligations  under any option  theretofore  granted to such  optionee  under the
Employee Plan.

Article 12  -  Stock Reserve
        The Company  shall at all times  during the terms of the  Employee  Plan
reserve  and keep  available  such  number  of  shares  of its  Stock as will be
sufficient to satisfy the  requirements of this Employee Plan, and shall pay all
fees and expenses  necessarily  incurred by the Company in  connection  with the
exercise of Options granted hereunder.

Article 13  -  Other Terms
        Any Option  granted  hereunder  shall contain such other and  additional
terms, not  inconsistent  with the terms of this Employee Plan, which are deemed
necessary or desirable by the Board,  the  Committee or by legal  counsel to the
Company, and such other terms shall include those which, together with the terms
of this Employee  Plan,  shall  constitute  such option as an  "Incentive  Stock
Option" within the meaning of Section 422 of the Internal Revenue Code.


                                     Page 5

<PAGE>


Article 14  -  Effective Date of Employee Plan and Shareholder Approval
        The effective  date of the Employee Plan is November 5, 1987;  provided,
however, if the Employee Plan is not approved by the shareholders of the Company
representing a majority of the voting power at the next shareholders  meeting or
if the Employee  Plan is not approved by such  shareholders  before  October 30,
1988, the Employee Plan shall terminate and any options granted thereunder shall
be void and have no force or effect.

        I hereby  certify that the  foregoing is a true and accurate copy of the
Employee  Incentive  Stock  Option Plan as adopted by the Board of  Directors of
RhoMed  Incorporated  at its meeting of November 5, 1987, and as approved by the
Shareholders at the regular Annual Meeting held on December 30, 1987; as amended
by the Board of  Directors  at its  meetings of February 3, 1990 and November 9,
1993;  and as amended  by  Consent  to Action  dated  January  14,  1994,  which
amendment was  subsequently  approved by the  Shareholders at the regular Annual
Meeting held on February 23, 1994.


                                           --------------------------------
                                           Secretary-Treasurer




                                     Page 6



                       1987 NONQUALIFIED STOCK OPTION PLAN

                               RHOMED INCORPORATED

Article 1 - Purpose
        The  Nonqualified  Stock Option Plan (the "Plan") is intended to advance
the interests of RhoMed  Incorporated  (the  "Company") and its  shareholders by
encouraging  and enabling  selected  officers and key  independent  contractors,
including  consultants,  directors and members of the scientific advisory board,
upon whose judgment,  initiative and effort the Company is largely dependent for
the  successful  conduct of its  business,  to acquire and retain a  proprietary
interest in the Company by ownership  of its stock.  Options  granted  under the
Plan are intended to be options  which do not meet the  requirements  of Section
422A of the Internal Revenue Code of 1986 (the "Code").

Article 2  -  Definitions
        As used in this document,  the following  terms have the meanings stated
unless the context clearly indicates to the contrary:
        2.1 "Board" shall mean the Board of Directors of the Company.
        2.2 "Committee" shall mean the body  administering the Plan, which shall
be the Compensation Committee of the Board, and if no Compensation Committee has
been established, it shall mean the Board.
        2.3 "Company" shall mean RhoMed Incorporated.
        2.4 "Option" shall mean an option to purchase Stock granted  pursuant to
the provisions of this Plan.
        2.5 "Optionee" shall mean an employee or independent  contractor to whom
an Option has been granted under this Plan.
        2.6 "Plan" shall mean this Nonqualified  Stock Option Plan, the terms of
which are set forth herein.
        2.7 "Stock" shall mean the Common Stock of the Company.
        2.8 "Stock  Option  Agreement"  shall  mean the  agreement  between  the
Company and an employee pursuant to the Plan.

Article 3 - Administration of Plan
        The Plan shall be administered by the Board or by the Committee, being a
committee  appointed by the Board. If the Plan is administered by the Committee,
it shall report all action  taken by it to the Board.  Options to members of the
Committee  may be granted  only a majority of the  disinterested  members of the
Board.  The  Committee  shall have full and final  authority in its  discretion,
subject to the provisions of the Plan, to determine the  individuals to whom and
the time or times at which options shall be granted and the number of shares and
purchase price of Common Stock covered by each option; to construe and interpret
the Plan; to determine the terms and provisions of the Stock Option  Agreements,
which need not be identical,  including, but without limitation,  terms covering
the payment of the option price; and to make all other determinations and

                                       -1-

<PAGE>



take  all  other   actions   deemed   necessary  or  advisable  for  the  proper
administration  of the  plan.  All  such  actions  and  determinations  shall be
conclusively binding for all purposes and upon all persons.

Article 4  -  Participants
        Options may be granted under the Plan to any person who is or who agrees
to become an officer or independent  contractor to the Company,  and who thereby
qualifies  under  Section  83  of  the  Code.  In  this  context,   "independent
contractor" shall include, without limitation, persons serving as members of the
Board who are not employees of the Company,  persons  serving as members of such
scientific  advisory  boards as may be,  from time to time,  constituted  by the
Company, and consultants.

Article 5  -  Grant of Options
        The  Committee is hereby  authorized  by majority vote of its members to
issue  Options  from  time to time on the  Company's  behalf  to any one or more
persons  who are  qualified  participants  as  defined  in Article 4. Any Option
granted under this Plan shall be granted within ten years from the date hereof.

Article 6  -  Amount of Stock
        The aggregate amount of Stock which may be purchased pursuant to options
granted under this Plan shall be 1,250,000 shares of the Company's Stock,  which
is Common Stock, no par value.

Article 7  -  Terms and Conditions of Options
        Any  Option  granted  pursuant  to this Plan shall  contain  provisions,
established  by the  Committee,  setting  forth the manner of  exercise  of such
Option. Such Stock Option Agreement shall be in writing, executed by the Company
and the applicable officer or independent contractor, and be in such form as the
Committee  may from time to time approve,  subject to the following  limitations
and conditions:
        7.1 Option Price. The Option price per share with respect to each option
shall be  determined  by the  Committee but shall in no instance be less than 85
percent of the fair  market  value of a share of the Stock on the date of grant.
For the  purposes  hereof,  fair  market  value  shall be as  determined  by the
Committee  and such  determination  shall be binding  upon the  Company  and the
optionee.
        7.2 Period of Option.  The expiration date of each option shall be fixed
by  the  Committee,  but,  notwithstanding  any  provision  of the  Plan  to the
contrary, such expiration date shall not be more than ten years from the date of
grant.
        7.3 Vesting of Shareholder Rights. Neither an optionee nor his successor
shall  have  any  of the  rights  of a  shareholder  of the  Company  until  the
certificates  evidencing  the shares  purchased  are properly  delivered to such
optionee or his successor.
        7.4 Exercise of Option.  Each option shall be  exercisable  from time to
time  over a  period  commencing  on the  date of  grant  and  ending  upon  the
expiration or termination of the option;  provided,  however, the Committee may,
by the provisions of any option agreement,  limit the number of shares purchased
thereunder  in any  period  or  periods  of time  during  which  the  option  is
exercisable. An option shall not be exercisable in whole or in part prior to the
date of shareholder approval of the Plan.
        7.5  Nontransferability  of Option.  No option shall be  transferable or
assignable  by an  optionee,  otherwise  than by will or the laws of descent and
distribution  and  each  option  shall be  exercisable,  during  the  optionee's
lifetime, only by him. No option shall be pledged or hypothecated

                                       -2-

<PAGE>



in any way and no option shall be subject to execution,  attachment,  or similar
process except with the express consent of the Committee.
        7.6  Limitations  on Exercise of Option  Rights.  The  optionee,  unless
otherwise  determined by the  Committee at the time the option is granted,  must
remain in the continuous employment of, or a continuous contractual relationship
with,  the Company  for one year from the date the option is granted  before any
part thereof or right thereunder may be exercised. Thereafter, the option may be
exercisable in whole or installments, as determined by the Committee at the time
the option is granted.
        7.7   Termination  of  Employment  or  Contractual   Arrangement.   Upon
termination  of an  optionee's  employment  with the  Company or with any of its
subsidiaries,  his option  privileges  shall be limited to the shares which were
immediately purchasable by him at the date of such termination.  The granting of
an option to an eligible person does not alter in any way the Company's existing
rights to terminate  such person's  employment  at any time for any reason,  nor
does it confer upon such person any rights or privileges  except as specifically
provided for in the Plan.
        7.8 Death of  Optionee.  If an optionee  dies while in the employ of the
Company,  his  option  privileges  shall be  limited  to the  shares  which were
immediately purchasable by him at the date of death.

Article 8  -  Adjustments
        8.1 In the event  that the  outstanding  shares  of Common  Stock of the
Company are hereafter  increased or decreased or changed into or exchanged for a
different  number or kind of shares or other  securities  of the  Company  or of
another corporation,  by reason of a recapitalization,  reclassification,  stock
split-up,  combination  of shares or dividend or other  distribution  payable in
capital  stock,  appropriate  adjustment  shall be made by the  Committee in the
number and kind of shares for the purchase of which options may be granted under
the Plan. In addition,  the Committee shall make  appropriate  adjustment in the
number and kind of shares as to which outstanding  options,  or portions thereof
then  unexercised,  shall be  exercisable,  to the end  that  the  proportionate
interest  of the  holder of the option  shall,  to the  extent  practicable,  be
maintained  as  before  the  occurrence  of  such  event.   Such  adjustment  in
outstanding  options shall be made without change in the total price  applicable
to the unexercised portion of the option but with a corresponding  adjustment in
the option price per share.
        8.2 In the event of the  dissolution or liquidation of the Company,  any
option  granted  under the Plan shall  terminate as of a date to be fixed by the
Committee,  provided that not less than 30 days'  written  notice of the date so
fixed shall be given to each  optionee  and each  optionee  shall have the right
during such  period to  exercise  his option as to all or any part of the shares
covered thereby  including shares as to which such option would not otherwise be
exercisable by reason of an insufficient lapse of time.
        8.3 In the event of a Reorganization (as hereafter defined) in which the
Company is not the surviving or acquiring company, or in which the Company is or
becomes a wholly owned subsidiary of another company after the effective date of
the Reorganization, then:
               8.3.1  If  there  is  no  plan  or   agreement   respecting   the
Reorganization  ("Reorganization  Agreement") or if the Reorganization Agreement
does not  specifically  provide  for the change,  conversion  or exchange of the
shares under outstanding and unexercised stock options

                                       -3-

<PAGE>



for  securities  of  another  corporation,  then the  Committee  shall take such
action, and the options shall terminate, as provided in Article 8.2; or
               8.3.2  If  there  is  a  Reorganization   Agreement  and  if  the
Reorganization  Agreement specifically provides for the change,  conversion,  or
exchange of the shares  under  outstanding  and  unexercised  stock  options for
securities of another  corporation,  then the Committee  shall adjust the shares
under such  outstanding  and  unexercised  stock  options  (and shall adjust the
shares  remaining  under the Plan which are then  available to be optioned under
the Plan, if the Reorganization  Agreement makes specific provision therefor) in
an manner not inconsistent with the provisions of the  Reorganization  Agreement
for the adjusted change, conversion or exchange of such stock and such options.
               8.3.3 The term  "Reorganization"  as used in Article  8.3 and its
subparts shall mean any statutory merger, statutory  consolidation,  sale of all
or  substantially  all of the assets of the  Company,  or sale,  pursuant  to an
agreement with the Company,  of securities of the Company  pursuant to which the
Company is or becomes a wholly owned  subsidiary  of another  company  after the
effective date of the Reorganization.
        8.4 Adjusts and  determinations  made under this Article 8 shall be made
by the Committee, whose decisions as to what adjustments or determinations shall
be made, and the extent thereof, shall be final, binding and conclusive.

Article 9  -  Restrictions on Issuing Shares
        The exercise of each option shall be subject to the condition that if at
any time the Company shall determine in its discretion that the  satisfaction of
withholding  tax  or  other  withholding  liabilities,   or  that  the  listing,
registration,  or qualification  of any shares  otherwise  deliverable upon such
such exercise upon any securities exchange or under any state or federal law, or
that the consent or approval of any  regulatory  body, is necessary or desirable
as a condition  of, or in  connection  with,  such  exercise or the  delivery or
purchase of shares pursuant thereto, then in any such event, such exercise shall
not be effective unless such withholding, listing, registration,  qualification,
consent, or approval shall have been effected or obtained free of any conditions
not acceptable to the Company.  The Committee may also impose such  restrictions
on any shares sold  pursuant to this Plan as it may deem  advisable,  including,
without  limitation,  restrictions under the Securities Act of 1933, as amended,
under the requirements of any stock exchange upon which such shares or shares of
the same  class  are then  listed,  and under  any blue sky or  securities  laws
applicable to such shares.

Article 10  -  Amendment, Suspension, and Termination of Plan
        10.1 The  Board may at any time  suspend  or  terminate  the Plan or may
amend it from time to time in such  respects as the Board may deem  advisable in
order that the options granted  thereunder may conform to any changes in the law
or in any other respect which the Board may deem to be in the best  interests of
the Company; provided, however, that without approval by the shareholders of the
Company representing a majority of the voting power, no such amendment shall:
               10.1.1  Except as  specified  in Article 8,  increase the maximum
number of shares for which options may be granted under the Plan;

                                       -4-

<PAGE>


               10.1.2    Change the  provisions  of Article 7.1  relating to the
establishment of the option price;

               10.1.3    Change the  provisions of  Article 7.2  relating to the
expiration date of each option; or,
               10.1.4  Change the  provisions  of  Article 10 and its  subparts,
relating to amendment, suspension and termination of the Plan.
        10.2 Unless the Plan shall theretofore have been terminated by the Board
or as  provided  in Article  12, the Plan shall  terminate  ten years  after the
effective  date of the Plan. No option may be granted  during any  suspension or
after  termination of the Plan.  Except as provided in Article 12, no amendment,
suspension,  or  termination of the Plan shall,  without an optionee's  consent,
alter or impair any of the rights or  obligations  under any option  theretofore
granted to such optionee under the Plan.

Article 11  -  Stock Reserve
        The Company  shall at all times during the terms of the Plan reserve and
keep  available  such  number of shares  of its Stock as will be  sufficient  to
satisfy  the  requirements  of this  Plan,  and shall pay all fees and  expenses
necessarily  incurred by the Company in connection  with the exercise of Options
granted hereunder.

Article 12  -  Effective Date of Plan and Shareholder Approval
        The effective date of the Plan is November 5, 1987;  provided,  however,
if the Plan is not approved by the  shareholders  of the Company  representing a
majority of the voting power at the next shareholders  meeting or if the Plan is
not  approved  by such  shareholders  before  October 30,  1988,  the Plan shall
terminate and any options granted  thereunder shall be void and have no force or
effect.


        I hereby  certify that the  foregoing is a true and accurate copy of the
Nonqualified  Stock  Option Plan as adopted by the Board of  Directors of RhoMed
Incorporated  at its  meeting  of  November  5,  1987,  and as  approved  by the
Shareholders  at the regular  Annual  Meeting held on December 30, 1987;  and as
amended by the Board of Directors at its meeting of September  17, 1988;  and as
amended by the Board of Directors  by Consent to Action  dated  December 4, 1991
and subsequently approved by the Shareholders at the regular Annual Meeting held
on December 15, 1991; and as amended by the Board of Directors at its meeting of
November 9, 1993 and  subsequently  approved by the  Shareholders at the regular
Annual Meeting held on February 23, 1994.



                                         --------------------------------
                                         Secretary-Treasurer

                                      -5-





                           PALATIN TECHNOLOGIES, INC.

                             1996 STOCK OPTION PLAN

1.      PURPOSE.

        The  purposes of the 1996 Stock  Option Plan (the  "Plan") are to induce
certain employees, consultants and directors to remain in the employ or service,
or to  continue  to serve as  directors,  of  Palatin  Technologies,  Inc.  (the
"Company")  and  its  present  and  future  subsidiary   corporations   (each  a
"Subsidiary"),  as defined in Section  424(f) of the  Internal  Revenue  Code of
1986, as amended (the  "Code"),  to attract new  individuals  to enter into such
employment or service and to encourage such individuals to secure or increase on
reasonable terms their stock ownership in the Company. The Board of Directors of
the Company  (the  "Board")  believes  that the  granting of stock  options (the
"Options")  under the Plan will promote  continuity of management  and increased
incentive  and personal  interest in the welfare of the Company by those who are
or may become primarily  responsible for shaping and carrying out the long range
plans of the Company and securing its continued  growth and  financial  success.
Options  granted  hereunder  are  intended  to be either  (a)  "incentive  stock
options" (which term, when used herein,  shall have the meaning ascribed thereto
by the  provisions  of Section  422(b) of the Code) or (b) options which are not
incentive  stock options  ("non-incentive  stock  options") or (c) a combination
thereof, as determined by the Committee (the "Committee") referred to in Section
4 hereof at the time of the grant thereof.



2.      EFFECTIVE DATE OF THE PLAN.

        The Plan became  effective on August 28,  1996,  by action of the Board,
subject to ratification by stockholders of the Company.



3.      STOCK SUBJECT TO PLAN.

        625,000 of  the  authorized  but  unissued  shares of the Common  Stock,
$0.01 par value,  of the Company  (the "Common  Stock") are hereby  reserved for
issue upon the exercise of Options  granted under the Plan;  provided,  however,
that the  number of shares so  reserved  may from time to time be reduced to the
extent  that a  corresponding  number of issued  and  outstanding  shares of the
Common  Stock are  purchased  by the  Company  and set aside for issue  upon the
exercise of Options.  If any Options  expire or terminate for any reason without
having been exercised in full,  the  unpurchased  shares  subject  thereto shall
again be available for the purposes of the Plan.



                                     Page 1

<PAGE>



4.      COMMITTEE.

        The Committee  shall consist of two or more members of the Board both or
all of whom  shall  be  "non-employee  directors"  within  the  meaning  of Rule
16b-3(b)(3)(i) promulgated under the Securities Exchange Act of 1934, as amended
(the "Exchange Act") and "outside directors" within the contemplation of Section
162(m)(4)(C)(i) of the Code. The President of the Company shall also be a member
of the Committee,  ex-officio, whether or not he or she is otherwise eligible to
be a member of the Committee.  The Committee shall be appointed  annually by the
Board,  which may at any time and from time to time  remove  any  members of the
Committee,  with or without cause,  appoint  additional members to the Committee
and fill  vacancies,  however  caused,  in the  Committee.  In the event that no
Committee shall have been appointed,  the Board shall serve as the Committee.  A
majority  of the  members  of the  Committee  shall  constitute  a  quorum.  All
determinations  of the  Committee  shall be made by a  majority  of its  members
present at a meeting duly called and held. Any decision or  determination of the
Committee  reduced to writing and signed by all of the members of the  Committee
shall be fully as  effective as if it had been made at a meeting duly called and
held.



5.      ADMINISTRATION.

        Subject to the express  provisions of the Plan, the Committee shall have
complete  authority,  in its  discretion,  to interpret  the Plan, to prescribe,
amend and rescind rules and  regulations  relating to it, to determine the terms
and provisions of the respective option  agreements or certificates  (which need
not be identical),  to determine the individuals  (each a "Participant") to whom
and the times and the prices at which  Options  shall be  granted,  the  periods
during  which  each  Option  shall be  exercisable,  the number of shares of the
Common  Stock to be subject to each Option and whether  such Option  shall be an
incentive  stock  option or a  non-incentive  stock option and to make all other
determinations  necessary or advisable  for the  administration  of the Plan. In
making such  determinations,  the  Committee may take into account the nature of
the services rendered by the respective employees and consultants, their present
and potential  contributions  to the success of the Company and the Subsidiaries
and such other factors as the Committee in its  discretion  shall deem relevant.
The Committee's determination on the matters referred to in this Section 5 shall
be conclusive.  Any dispute or disagreement which may arise under or as a result
of or with respect to any Option shall be  determined by the  Committee,  in its
sole discretion,  and any  interpretations  by the Committee of the terms of any
Option shall be final, binding and conclusive.



6.      ELIGIBILITY.

        A. An Option may be granted only to (i) an employee or consultant of the
Company or a  Subsidiary,  (ii) a director of the Company who is not employed by
the Company or any of the  Subsidiaries  (a  "Non-Employee  Director") and (iii)
employees of a corporation or other business  enterprise which has been acquired
by the  Company or a  Subsidiary,  whether by  exchange  or  purchase  of stock,
purchase of assets, merger or reverse merger or otherwise, who hold options

                                     Page 2

<PAGE>



with  respect to the stock of such  corporation  which the Company has agreed to
assume or for which the Company has agreed to provide substitute options.

        B. (i) On August 28, 1996, each  Non-Employee  Director shall be granted
an Option (a "Non-Employee Director's Formula Option") to purchase 20,000 shares
of the Common Stock at the initial per share option price of $1.36 per share.

        (ii) At the first meeting of the Board immediately  following the annual
meeting of the  Stockholders of the Company held following the effective date of
the Plan,  and at the first  meeting  of the Board  immediately  following  each
subsequent annual meeting of the Stockholders of the Company,  each Non-Employee
Director shall be granted an Option (a "Non-Employee Director's Formula Option")
to purchase  10,000  shares  (after  giving  effect to the  reverse  stock split
effected  on  September  5, 1997) of the Common  Stock at the  initial per share
option  price equal to the fair market  value of a share of the Common  Stock on
the date of grant.

        (iii) Each  Non-Employee  Director who becomes a director  subsequent to
the adoption  date of the Plan,  and prior to the date of any annual  meeting of
the Stockholders of the Company, shall be granted, on the date he or she becomes
a director,  an Option (a "Non-Employee  Director's Formula Option") to purchase
the number of shares (after giving effect to the reverse stock split effected on
September  5, 1997) of the Common  Stock  equal to the product of (i) 10,000 and
(ii) a fraction,  the numerator of which is the number of full  calendar  months
prior to the next scheduled  annual meeting of Stockholders  and the denominator
of which is 12, at the initial per share  option  price equal to the fair market
value of a share of the Common Stock on the date of grant.

        (iv) A Non-Employee Director may not exercise a Non-Employee  Director's
Formula Option during the period  commencing on the date of the granting of such
Option to him or her and ending on the day next preceding the first  anniversary
of such date. A  Non-Employee  Director may (i) during the period  commencing on
the first  anniversary of the date of the granting of a Non-Employee  Director's
Formula  Option to him or her and  ending on the day next  preceding  the second
anniversary of such date, exercise such Option with respect to one-fourth of the
shares  granted  thereby,  (ii)  during the  period  commencing  on such  second
anniversary  and ending on the day next  preceding the third  anniversary of the
date of the  granting of such  Option,  exercise  such  Option  with  respect to
one-half of the shares granted  thereby,  (iii) during the period  commencing on
such  third  anniversary  and  ending  on the date  next  preceding  the  fourth
anniversary  of the date of the  granting of such Option,  exercise  such Option
with respect to  three-fourths of the shares granted thereby and (iv) during the
period  commencing  on such  fourth  anniversary  and  ending on the date of the
expiration  of such  Option,  exercise  such Option  with  respect to all of the
shares granted thereby.

7.      OPTION PRICES.

        A.  Except as  otherwise  provided in Sections 6 and 17, the initial per
share option price of any Option shall be the price determined by the Committee,
but not less than the fair  market  value of a share of the Common  Stock on the
date of grant;  provided,  however,  that, in the case of a Participant who owns
(within the meaning of Section 424(d) of the Code) more than 10% of the

                                     Page 3

<PAGE>



total  combined  voting power of the Common Stock at the time an Option which is
an incentive stock option is granted to him or her, the initial per share option
price  shall not be less than  110% of the fair  market  value of a share of the
Common Stock on the date of grant.

        B. For all purposes of the Plan, the fair market value of a share of the
Common Stock on any date shall be determined by the Committee as follows:

        (i) If the Common Stock is listed on the OTC Electronic  Bulletin Board,
its fair market  value shall be the closing  selling  price on such date for the
Common Stock as reported on the OTC Electronic  Bulletin  Board. If there are no
sales of the Common Stock on that date, then the reported  closing selling price
for the Common Stock on the next preceding  date for which such closing  selling
price is quoted shall be determinative of fair market value; or,

        (ii) If the Common Stock is listed on any established  stock exchange or
a national  market system,  including  without  limitation,  the Nasdaq National
Market System or the Nasdaq SmallCap Market System,  its fair market value shall
be the reported  closing  selling  price for the Common  Stock on the  principal
securities  exchange or national  market  system on which the Common Stock is at
such date  listed  for  trading.  If there are no sales of Common  Stock on that
date,  then the reported  closing selling price for the Common Stock on the next
preceding  day  for  which  such  closing  selling  price  is  quoted  shall  be
determinative of fair market value; or,

        (iii) If the Common Stock is not traded on the OTC  Electronic  Bulletin
Board, an exchange,  or a national market system, its fair market value shall be
determined  in good  faith by the  Committee,  and such  determination  shall be
conclusive and binding on all persons.



8.      OPTION TERM.

        Participants  shall be granted  Options  for such term as the  Committee
shall  determine,  not in  excess  of ten  years  from the date of the  granting
thereof; provided, however, that, except as otherwise provided in Section 17, in
the case of a Participant  who owns (within the meaning of Section 424(d) of the
Code) more than 10% of the total  combined  voting  power of the Common Stock of
the Company at the time an Option which is an incentive  stock option is granted
to him or her,  the term with  respect to such Option  shall not be in excess of
five years from the date of the granting thereof;  provided,  further,  however,
that the term of each Non-Employee  Director's Formula Option shall be ten years
from the date of the granting thereof.



9.      LIMITATIONS ON AMOUNT OF OPTIONS GRANTED.

        A. Except as otherwise provided in Section 17, the aggregate fair market
value of the shares of the Common Stock for which any Participant may be granted
incentive stock options which are exercisable for the first time in any calendar
year (whether  under the terms of the Plan or any other stock option plan of the
Company) shall not exceed $100,000.

                                     Page 4

<PAGE>



        B. Except as  otherwise  provided in Section 17, no  Participant  shall,
during any fiscal year of the Company,  be granted Options to purchase more than
500,000 shares of the Common Stock.



10.     EXERCISE OF OPTIONS.

        A. Except as  otherwise  provided in Section 17 and except as  otherwise
determined  by the  Committee at the time of the grant of an Option other than a
Non-Employee Director's Formula Option, a Participant may not exercise an Option
during the period  commencing  on the date of the granting of such Option to him
or her and ending on the day next preceding the first  anniversary of such date.
Except  as  otherwise  set  forth  in  Sections  9A and 17 and in the  preceding
sentence,  a  Participant  may (i)  during the  period  commencing  on the first
anniversary of the date of the granting of an Option to him or her and ending on
the day next preceding the second anniversary of such date, exercise such Option
with respect to one-fourth of the shares granted thereby, (ii) during the period
commencing on such second  anniversary  and ending on the day next preceding the
third  anniversary  of the date of the  granting of such Option,  exercise  such
Option with respect to one-half of the shares granted thereby,  (iii) during the
period  commencing  on such  third  anniversary  and  ending  on the  date  next
preceding  the fourth  anniversary  of the date of the  granting of such Option,
exercise such Option with respect to three-fourths of the shares granted thereby
and (iv) during the period  commencing on such fourth  anniversary and ending on
the date of the expiration of such Option,  exercise such Option with respect to
all of the shares granted thereby.

        B.  Except  as  hereinbefore  otherwise  set  forth,  an  Option  may be
exercised either in whole at any time or in part from time to time.

        C. An Option  may be  exercised  only by a  written  notice of intent to
exercise  such Option with respect to a specific  number of shares of the Common
Stock and  payment to the  Company  of the  amount of the  option  price for the
number of shares of the Common Stock so specified.

        D. Except in the case of a Non-Employee  Director's  Formula Option, the
Board may, in its discretion,  permit any Option to be exercised, in whole or in
part, prior to the time when it would otherwise be exercisable.

        E.  Notwithstanding  any other  provision  of the Plan to the  contrary,
including, but not limited to, the provisions of Section 10D, if any Participant
shall have effected a "Hardship  Withdrawal"  from a "401(k) Plan" maintained by
the Company and/or one or more of the  Subsidiaries,  then, during the period of
one year commencing on the date of such Hardship  Withdrawal,  such  Participant
may not  exercise  any Option.  For the purpose of this  paragraph E, a Hardship
Withdrawal  shall mean a distribution to a Participant  provided for in Reg. ss.
1.401(k)- 1(d)(1)(ii) promulgated under Section  401(k)(2)(B)(i)(iv) of the Code
and a 401(k)  Plan  shall  mean a plan which is a  "qualified  plan"  within the
contemplation  of section 401(a) of the Code which contains a "qualified cash or
deferred arrangement" within the contemplation of section 401(k)(2) of the Code.

                                     Page 5

<PAGE>



11.     TRANSFERABILITY.

        No Option shall be assignable or  transferable  except by will and/or by
the laws of descent and  distribution  and, during the life of any  Participant,
each Option granted to him or her may be exercised only by him or her.



12.     TERMINATION OF EMPLOYMENT.

        A. In the event a  Participant  leaves the employ of the Company and the
Subsidiaries  or  ceases to serve as a  consultant  to the  Company  and/or as a
Non-Employee  Director of the Company,  whether  voluntarily or otherwise,  each
Option  theretofore  granted  to him or her  which  shall  not have  theretofore
expired or  otherwise  been  cancelled  shall,  to the  extent  not  theretofore
exercised,  terminate  upon the  earlier to occur of the  expiration  of 90 days
after the date of such  Participant's  termination  of employment or service and
the date of termination specified in such Option. Notwithstanding the foregoing,
if a Participant's  employment by the Company and the Subsidiaries or service as
a consultant and/or as a Non-Employee  Director of the Company is terminated for
"cause" (as defined herein), each Option theretofore granted to him or her which
shall not have  theretofore  expired or otherwise been cancelled  shall,  to the
extent not theretofore exercised, terminate forthwith.

        B. For purposes of the  foregoing,  the term "cause" shall mean: (i) the
commission by a Participant of any act or omission that would constitute a crime
under  federal,  state or  equivalent  foreign  law,  (ii) the  commission  by a
Participant of any act of moral turpitude, (iii) fraud, dishonesty or other acts
or omissions  that result in a breach of any fiduciary or other material duty to
the Company and/or the Subsidiaries or (iv) continued alcohol or other substance
abuse that renders a  Participant  incapable of  performing  his or her material
duties to the satisfaction of the Company and/or the Subsidiaries.



13.     ADJUSTMENT OF NUMBER OF SHARES.

        A. In the event that a dividend  shall be declared upon the Common Stock
payable in shares of the Common Stock,  the number of shares of the Common Stock
then subject to any Option and the number of shares of the Common Stock reserved
for issuance in accordance  with the  provisions of the Plan but not yet covered
by an Option and the number of shares set forth in  Sections  6B and 9B shall be
adjusted  by  adding  to  each  share  the  number  of  shares  which  would  be
distributable  thereon if such shares had been outstanding on the date fixed for
determining the  stockholders  entitled to receive such stock  dividend.  In the
event that the  outstanding  shares of the Common Stock shall be changed into or
exchanged for a different  number or kind of shares of stock or other securities
of the  Company  or of  another  corporation,  whether  through  reorganization,
recapitalization,  stock split-up, combination of shares, sale of assets, merger
or consolidation in which the Company is the surviving corporation,  then, there
shall be  substituted  for each  share of the Common  Stock then  subject to any
Option  and for  each  share  of the  Common  Stock  reserved  for  issuance  in
accordance with the provisions of the Plan but not yet

                                     Page 6

<PAGE>



covered  by an Option  and for each share of the  Common  Stock  referred  to in
Sections  6B and 9B, the number and kind of shares of stock or other  securities
into which each outstanding share of the Common Stock shall be so changed or for
which each such share shall be exchanged.

        B. In the event that there shall be any change,  other than as specified
in Section 13, in the number or kind of outstanding  shares of the Common Stock,
or of any stock or other  securities into which the Common Stock shall have been
changed,  or for which it shall  have been  exchanged,  then,  if the  Committee
shall, in its sole discretion,  determine that such change equitably requires an
adjustment  in the number or kind of shares  then  subject to any Option and the
number or kind of shares reserved for issuance in accordance with the provisions
of the Plan but not yet  covered  by an Option  and the number or kind of shares
referred  to in  Sections  6B and  9B,  such  adjustment  shall  be  made by the
Committee and shall be effective and binding for all purposes of the Plan and of
each stock option  agreement or certificate  entered into in accordance with the
provisions of the Plan.

        C. In the case of any  substitution or adjustment in accordance with the
provisions  of this Section 13, the option price in each stock option  agreement
or  certificate  for each share covered  thereby prior to such  substitution  or
adjustment shall be the option price for all shares of stock or other securities
which  shall have been  substituted  for such share or to which such share shall
have been adjusted in accordance with the provisions of this Section 13.

        D. No adjustment or  substitution  provided for in this Section 13 shall
require the Company to sell a fractional  share under any stock option agreement
or certificate.

        E. In the event of the  dissolution or liquidation of the Company,  or a
merger,  reorganization  or  consolidation  in  which  the  Company  is not  the
surviving corporation, then, except as otherwise provided in the second sentence
of Section 13A,  each Option,  to the extent not  theretofore  exercised,  shall
terminate forthwith.



14.     PURCHASE FOR INVESTMENT, WITHHOLDING AND WAIVERS.

        A.  Unless the shares to be issued  upon the  exercise of an Option by a
Participant  shall  be  registered  prior  to the  issuance  thereof  under  the
Securities  Act of 1933, as amended,  such Par ticipant  will, as a condition of
the  Company's   obligation  to  issue  such  shares,  be  required  to  give  a
representation in writing that he or she is acquiring such shares for his or her
own account as an  investment  and not with a view to, or for sale in connection
with, the distribution of any thereof.

        B. In the event of the death of a Participant, a condition of exercising
any Option  shall be the  delivery  to the Company of such tax waivers and other
documents as the Committee shall determine.

        C. In the  case of each  non-incentive  stock  option,  a  condition  of
exercising  the same shall be the entry by the person  exercising  the same into
such  arrangements with the Company with respect to withholding as the Committee
may determine.



                                     Page 7

<PAGE>



15.     NO STOCKHOLDER STATUS.

        Neither any Participant nor his or her legal  representatives,  legatees
or  distributees  shall be or be  deemed  to be the  holder  of any share of the
Common Stock covered by an Option unless and until a certificate  for such share
has been issued. Upon payment of the purchase price thereof, a share issued upon
exercise of an Option shall be fully paid and non-assessable.



16.     NO RESTRICTIONS ON CORPORATE ACTS.

        Neither the existence of the Plan nor any Option shall in any way affect
the right or power of the Company or its  stockholders  to make or authorize any
or all adjustments,  recapitalizations,  reorganizations or other changes in the
Company's capital  structure or its business,  or any merger or consolidation of
the Company,  or any issue of bonds,  debentures,  preferred or prior preference
stock  ahead  of or  affecting  the  Common  Stock  or the  rights  thereof,  or
dissolution or liquidation of the Company, or any sale or transfer of all or any
part of its assets or business, or any other corporate act or proceeding whether
of a similar character or otherwise.



17.     OPTIONS GRANTED IN CONNECTION WITH ACQUISITIONS.

        In the event that the Committee  determines that, in connection with the
acquisition  by the Company or a Subsidiary  of another  corporation  which will
become a Subsidiary or division of the Company or a Subsidiary (such corporation
being hereafter referred to as an "Acquired Subsidiary"), Options may be granted
hereunder to employees and other personnel of an Acquired Subsidiary in exchange
for then outstanding options to purchase securities of the Acquired  Subsidiary.
Such  Options  may  be  granted  at  such  option  prices,  may  be  exercisable
immediately  or at any time or times either in whole or in part, and may contain
such other  provisions not  inconsistent  with the Plan, or the requirements set
forth in Section  19 that  certain  amendments  to the Plan be  approved  by the
stockholders of the Company,  as the Committee,  in its  discretion,  shall deem
appropriate at the time of the granting of such Options.



18.     NO EMPLOYMENT OR SERVICE RIGHT.

        Neither  the  existence  of the Plan nor the grant of any  Option  shall
require the Company or any Subsidiary to continue any  Participant in the employ
of the  Company or such  Subsidiary  or require  the  Company  to  continue  any
Participant as a director of the Company.



19.     TERMINATION AND AMENDMENT OF THE PLAN.

        The Board may at any time terminate the Plan or make such  modifications
of the Plan as it shall deem advisable;  provided,  however,  that the Board may
not without  further  approval of the holders of a majority of the shares of the
Common Stock  present in person or by proxy at any special or annual  meeting of
the stockholders, increase the number of shares as to which Options

                                     Page 8

<PAGE>


may be granted under the Plan (as adjusted in accordance  with the provisions of
Section 13), or change the manner of determining  the option  prices,  or extend
the  period  during  which an Option  may be  granted  or  exercised;  provided,
however,  the  provisions  of the  Plan  governing  the  grant  of  Non-Employee
Director's  Formula  Options may not be amended except by the vote of a majority
of the  members of the Board and by the vote of a majority of the members of the
Board who are employees of the Company or a Subsidiary  and shall not be amended
more than once every six months, other than to comport with changes in the Code,
the  Employee  Retirement  Income  Security  Act of  1974  or the  Rules  of the
Securities and Exchange Commission  promulgated under Section 16 of the Exchange
Act. Except as otherwise  provided in Section 13, no termination or amendment of
the Plan may,  without the consent of the  Participant  to whom any Option shall
theretofore  have been granted,  adversely affect the rights of such Participant
under such Option.



20.     EXPIRATION AND TERMINATION OF THE PLAN.

        The Plan shall  terminate  on August 27, 2006 or at such earlier time as
the Board may  determine.  Options may be granted under the Plan at any time and
from time to time prior to its  termination.  Any Option  outstanding  under the
Plan at the time of the  termination  of the Plan shall  remain in effect  until
such Option shall have been  exercised or shall have expired in accordance  with
its terms.



















                                     Page 9



                        CARL SPANA STOCK OPTION AGREEMENT

        Palatin  Technologies,  Inc., a Delaware corporation (the "Company") and
Carl Spana ("Optionee") agree:

        1.  Recitals.  As of the date hereof,  the  Stockholders  of the Company
approved the grant of a nonqualified stock option to Optionee to purchase 74,196
shares of Palatin  Common  Stock (as  defined in Section 2 below) at an exercise
price of $1.00 per  share  (the  "New  Option")  for the  purpose  of  providing
additional compensation to Optionee. This Carl Spana Stock Option Agreement (the
"Agreement") sets forth the terms and conditions of such grant, and is effective
as of March 24, 1998.

        On  December 4, 1997,  the Board of  Directors  of the Company  adopted,
subject to stockholder approval, a resolution whereby certain options previously
granted to Optionee (the "Original  Options") under plans of RhoMed Incorporated
("RhoMed") would be replaced by the New Option. Upon stockholder approval of the
New Option, the Original Options immediately terminated.

        2. Definitions. In addition to capitalized terms defined in context, the
following capitalized terms have the following meanings in this Agreement:
        "1995 EISOP" means RhoMed's 1995 Employee Incentive Stock Option Plan.
        "1995 NQSOP" means RhoMed's 1995 Nonqualified Stock Option Plan.
        "Code"  means  the  Internal  Revenue  Code of  1986,  as  amended,  and
regulations  promulgated under the Internal Revenue Code of 1986, as amended, or
any successor legislation and regulations.
        "Committee"  means the Compensation  Committee of the Company's Board of
Directors,  or if the  Company's  Board  of  Directors  has  not  established  a
Compensation Committee, then it is the Company's Board of Directors.
        "Employee"  means an employee,  as  determined  in  accordance  with the
withholding tax rules under Code section 3401(c), of the Company, its parent, as
defined in Code  section  424(e),  or  subsidiary,  as  defined in Code  section
424(f).
        "Option  Price"  means the number of shares of Option  Stock as to which
the New Option is being exercised, multiplied by the Exercise Price per share.
        "Option  Stock" means Palatin Common Stock obtained upon exercise of the
New Option.
        "Palatin  Common  Stock"  means the $.01 par value  common  stock of the
Company, or any other stock issuable upon exercise of the New Option as adjusted
pursuant to this  Agreement,  or as  substituted or assumed as permitted by this
Agreement.

        3. Termination of Original Options.  Effective as of March 24, 1998, the
following  Original  Options set forth below at the purchase price indicated are
terminated:


<PAGE>




- - --------------------------------------------------------------------------------
      RHOMED     DATE OF                   EXERCISE PRICE      EXERCISE PRICE
       PLAN       GRANT    OPTION STOCK     (AGGREGATE)         (PER SHARE)
- - --------------------------------------------------------------------------------
    1995 EISOP   6/21/96      73,732.99     $399,999.75            $5.42
- - --------------------------------------------------------------------------------
    1995 NQSOP   6/21/96         464.84       $2,521.75            $5.42
- - --------------------------------------------------------------------------------

        4. Grant of New  Option.  Effective  as of March 24,  1998,  the Company
grants a  nonqualified  stock  option to Optionee to purchase  74,196  shares of
Palatin Common Stock of the Company at an exercise price of $1.00 per share (the
"Exercise Price").

        5.   Exercisability  of  New  Option.  The  New  Option  is  immediately
exercisable by Optionee as to two-thirds of the total number of shares, with the
remaining one-third  exercisable on June 21, 1998. The exercisability of the New
Option is  cumulative,  so that  after any  portion  of the New  Option  becomes
exercisable,  that portion will remain  exercisable  until the Final  Expiration
Date (as defined in Section 7 below).

        6. Exercise of Option; conditions on exercise. If the Company determines
that  exercise of the New Option or issuance  of Option  Stock will  violate any
tax,  securities or other law or regulation,  then the Optionee may not exercise
the New Option until the Company  determines  that the exercise or issuance will
comply with that law or regulation.  Otherwise, the Optionee may exercise all or
any part of the  exercisable  portion  of the New Option by  delivering  written
notice directed to the Vice President and Chief Financial Officer of the Company
at the Company's  principal place of business (214 Carnegie  Center,  Suite 100,
Princeton,  New Jersey,  08540, or such other address as the Company may specify
in writing to the Optionee),  stating the number of shares of Option Stock which
the Optionee  intends to purchase,  along with payment in immediately  available
U.S. funds of the Option Price for the number of shares specified, and the entry
by the Optionee into such  arrangements with the Company with respect to federal
income tax withholding as the Company may reasonably  require.  The Company will
issue  and  deliver  the  shares  promptly  upon  exercise.  In lieu of  issuing
fractional  shares of Palatin  Common  Stock,  the Company will pay the Optionee
cash for any fraction of a share  exercised,  at the rate of the closing  market
price per share of Palatin  Common  Stock on the date of  exercise  or last date
preceding  exercise on which Palatin  Common Stock was traded,  as quoted on any
national securities  exchange or automated  quotation system,  including the OTC
Electronic Bulletin Board, on which the Palatin Common Stock is traded.

        7. Period for exercise of New Option. The New Option will be exercisable
until  June  21,  2006  (the  "Final  Expiration  Date"),   subject  to  earlier
termination as set forth in Section 8 below.


                                        2

<PAGE>



        8.  Termination  of employment  and New Option.  The granting of the New
Option does not grant any right to the Optionee to continue as an  Employee.  On
the date when the  Optionee  ceases to be an Employee  for any  reason,  the New
Option will, to the extent that such New Option is not immediately  exercisable,
terminate,  and to the extent that such New Option is  immediately  exercisable,
terminate  upon  the  earlier  of 90  days  after  the  date of  termination  of
employment and the Final Expiration Date.

        9.  Accelerated  exercisability  and early  expiration  of New Option in
certain  corporate  transactions.  If the Company  enters into an  agreement  to
engage in a transaction  to which Code section  424(a) would apply if the Option
were an incentive  option as defined in Code section 422 and the requirements of
Code  sections  424(a)(1)  and  424(a)(2)  were met, and no  corporation  either
substitutes a new option for or assumes the New Option,  or agrees in writing to
do so upon  consummation of the transaction,  then thirty days before the agreed
date of consummation of the transaction,  the New Option will become exercisable
as to the entire  amount of Option  Stock and will  expire on the earlier of (i)
consummation  of the  transaction or (ii) the New Option's  original  expiration
date.  The Committee will give the Optionee  written  notice of the  accelerated
exercisability  and potential early expiration of the New Option at least thirty
days before its potential early expiration date.

        10. Changes in Stock. If the Company's stockholders approve an amendment
to the  Company's  certificate  of  incorporation  which effects a change in the
Palatin Common Stock or rights of Palatin Common Stock holders,  or an exchange,
reclassification  or  cancellation  of the  Palatin  Common  Stock or  rights of
Palatin Common Stock holders,  then the Committee  will  immediately  adjust the
amount and/or class of Option Stock and/or the Option Price so that the
New Option will be exercisable at the same aggregate curities which the Optionee
would have been entitled to receive had the Optionee exercised the New Option in
full before the amendment.

        11.  Transferability  of New Option and Option Stock.  The New Option is
not transferable otherwise than by will or the laws of descent and distribution,
and is exercisable,  during the Optionee's lifetime,  only by the Optionee.  The
Company may restrict  transferability  of Option Stock issued upon exercise,  in
order to comply,  in the Company's  judgment,  with federal and state securities
laws and/or the  requirements  of any stock exchange on which the Palatin Common
Stock is then traded.

        12. Purchase for investment and withholding. Unless the Option Shares to
be issued upon the exercise of the New Option shall be  registered  prior to the
issuance  thereof under the  Securities  Act of 1933,  as amended,  the Optionee
will, as a condition of the Company's obligation to issue such Option Shares, be
required to give a  representation  in writing that he is acquiring  such shares
for his own  account  as an  investment  and not with a view to,  or for sale in
connection with, the distribution of any thereof.

                                        3

<PAGE>



        13.  Stockholder  rights.   Neither  the  Optionee  nor  the  Optionee's
successor has any of the rights of a stockholder of the Company, with respect to
any Option Stock,  until the Company has received  payment in full of the Option
Price for that Option Stock upon exercise.

        14.  Miscellaneous.  This  Agreement  benefits  and  is  binding  on the
parties,  their  successors and assigns,  represents the entire agreement of the
parties as to its subject matter,  may be modified only in writing signed by the
parties  (except as  permitted  under  paragraph 10 of this  Agreement),  and is
governed by the laws of the state of Delaware.

Dated as of March 24, 1998.

Palatin Technologies, Inc.                                  Optionee:



by___________________________                        ___________________________
        Stephen T. Wills                                    Carl Spana
        Vice President and
            Chief Financial Officer





                                        4



                    CHARLES L. PUTNAM STOCK OPTION AGREEMENT

        Palatin  Technologies,  Inc., a Delaware corporation (the "Company") and
Charles L. Putnam ("Optionee") agree:

        1.  Recitals.  As of the date hereof,  the  Stockholders  of the Company
approved the grant of a nonqualified stock option to Optionee to purchase 74,196
shares of Palatin  Common  Stock (as  defined in Section 2 below) at an exercise
price of $1.00 per  share  (the  "New  Option")  for the  purpose  of  providing
additional  compensation  to  Optionee.  This  Charles L.  Putnam  Stock  Option
Agreement (the  "Agreement")  sets forth the terms and conditions of such grant,
and is effective as of March 24, 1998.

        On  December 4, 1997,  the Board of  Directors  of the Company  adopted,
subject to stockholder approval, a resolution whereby certain options previously
granted to Optionee (the "Original  Options") under plans of RhoMed Incorporated
("RhoMed") would be replaced by the New Option. Upon stockholder approval of the
New Option, the Original Options immediately terminated.

        2. Definitions. In addition to capitalized terms defined in context, the
following capitalized terms have the following meanings in this Agreement:
        "1995 EISOP" means RhoMed's 1995 Employee Incentive Stock Option Plan.
        "1995 NQSOP" means RhoMed's 1995 Nonqualified Stock Option Plan.
        "Code"  means  the  Internal  Revenue  Code of  1986,  as  amended,  and
regulations  promulgated under the Internal Revenue Code of 1986, as amended, or
any successor legislation and regulations.
        "Committee"  means the Compensation  Committee of the Company's Board of
Directors,  or if the  Company's  Board  of  Directors  has  not  established  a
Compensation Committee, then it is the Company's Board of Directors.
        "Employee"  means an employee,  as  determined  in  accordance  with the
withholding tax rules under Code section 3401(c), of the Company, its parent, as
defined in Code  section  424(e),  or  subsidiary,  as  defined in Code  section
424(f).
        "Option  Price"  means the number of shares of Option  Stock as to which
the New Option is being exercised, multiplied by the Exercise Price per share.
        "Option  Stock" means Palatin Common Stock obtained upon exercise of the
New Option.
        "Palatin  Common  Stock"  means the $.01 par value  common  stock of the
Company, or any other stock issuable upon exercise of the New Option as adjusted
pursuant to this  Agreement,  or as  substituted or assumed as permitted by this
Agreement.

        3. Termination of Original Options.  Effective as of March 24, 1998, the
following  Original  Options set forth below at the purchase price indicated are
terminated:


<PAGE>




- - --------------------------------------------------------------------------------
      RHOMED        DATE OF                     EXERCISE PRICE   EXERCISE PRICE
       PLAN          GRANT      OPTION STOCK     (AGGREGATE)       (PER SHARE)
- - --------------------------------------------------------------------------------
    1995 EISOP     6/21/96       73,732.99       $399,999.75         $5.42
- - --------------------------------------------------------------------------------
    1995 NQSOP     6/21/96          464.84         $2,521.75         $5.42
- - --------------------------------------------------------------------------------

        4. Grant of New  Option.  Effective  as of March 24,  1998,  the Company
grants a  nonqualified  stock  option to Optionee to purchase  74,196  shares of
Palatin Common Stock of the Company at an exercise price of $1.00 per share (the
"Exercise Price").

        5.   Exercisability  of  New  Option.  The  New  Option  is  immediately
exercisable  by Optionee as to one-third of the total number of shares,  with an
additional  one-third  exercisable on June 21, 1998 and the remaining  one-third
exercisable  on  June  21,  1999.  The  exercisability  of  the  New  Option  is
cumulative,  so that after any  portion of the New Option  becomes  exercisable,
that portion will remain exercisable until the Final Expiration Date (as defined
in Section 7 below).

        6. Exercise of Option; conditions on exercise. If the Company determines
that  exercise of the New Option or issuance  of Option  Stock will  violate any
tax,  securities or other law or regulation,  then the Optionee may not exercise
the New Option until the Company  determines  that the exercise or issuance will
comply with that law or regulation.  Otherwise, the Optionee may exercise all or
any part of the  exercisable  portion  of the New Option by  delivering  written
notice directed to the Vice President and Chief Financial Officer of the Company
at the Company's  principal place of business (214 Carnegie  Center,  Suite 100,
Princeton,  New Jersey,  08540, or such other address as the Company may specify
in writing to the Optionee),  stating the number of shares of Option Stock which
the Optionee  intends to purchase,  along with payment in immediately  available
U.S. funds of the Option Price for the number of shares specified, and the entry
by the Optionee into such  arrangements with the Company with respect to federal
income tax withholding as the Company may reasonably  require.  The Company will
issue  and  deliver  the  shares  promptly  upon  exercise.  In lieu of  issuing
fractional  shares of Palatin  Common  Stock,  the Company will pay the Optionee
cash for any fraction of a share  exercised,  at the rate of the closing  market
price per share of Palatin  Common  Stock on the date of  exercise  or last date
preceding  exercise on which Palatin  Common Stock was traded,  as quoted on any
national securities  exchange or automated  quotation system,  including the OTC
Electronic Bulletin Board, on which the Palatin Common Stock is traded.

        7. Period for exercise of New Option. The New Option will be exercisable
until  June  21,  2006  (the  "Final  Expiration  Date"),   subject  to  earlier
termination as set forth in Section 8 below.


                                        2

<PAGE>



        8.  Termination  of employment  and New Option.  The granting of the New
Option does not grant any right to the Optionee to continue as an  Employee.  On
the date when the  Optionee  ceases to be an Employee  for any  reason,  the New
Option will, to the extent that such New Option is not immediately  exercisable,
terminate,  and to the extent that such New Option is  immediately  exercisable,
terminate  upon  the  earlier  of 90  days  after  the  date of  termination  of
employment and the Final Expiration Date.

        9.  Accelerated  exercisability  and early  expiration  of New Option in
certain  corporate  transactions.  If the Company  enters into an  agreement  to
engage in a transaction  to which Code section  424(a) would apply if the Option
were an incentive  option as defined in Code section 422 and the requirements of
Code  sections  424(a)(1)  and  424(a)(2)  were met, and no  corporation  either
substitutes a new option for or assumes the New Option,  or agrees in writing to
do so upon  consummation of the transaction,  then thirty days before the agreed
date of consummation of the transaction,  the New Option will become exercisable
as to the entire  amount of Option  Stock and will  expire on the earlier of (i)
consummation  of the  transaction or (ii) the New Option's  original  expiration
date.  The Committee will give the Optionee  written  notice of the  accelerated
exercisability  and potential early expiration of the New Option at least thirty
days before its potential early expiration date.

        10. Changes in Stock. If the Company's stockholders approve an amendment
to the  Company's  certificate  of  incorporation  which effects a change in the
Palatin Common Stock or rights of Palatin Common Stock holders,  or an exchange,
reclassification  or  cancellation  of the  Palatin  Common  Stock or  rights of
Palatin Common Stock holders,  then the Committee  will  immediately  adjust the
amount and/or class of Option Stock and/or the Option Price so that the
New Option will be exercisable at the same aggregate curities which the Optionee
would have been entitled to receive had the Optionee exercised the New Option in
full before the amendment.

        11.  Transferability  of New Option and Option Stock.  The New Option is
not transferable otherwise than by will or the laws of descent and distribution,
and is exercisable,  during the Optionee's lifetime,  only by the Optionee.  The
Company may restrict  transferability  of Option Stock issued upon exercise,  in
order to comply,  in the Company's  judgment,  with federal and state securities
laws and/or the  requirements  of any stock exchange on which the Palatin Common
Stock is then traded.

        12. Purchase for investment and withholding. Unless the Option Shares to
be issued upon the exercise of the New Option shall be  registered  prior to the
issuance  thereof under the  Securities  Act of 1933,  as amended,  the Optionee
will, as a condition of the Company's obligation to issue such Option Shares, be
required to give a  representation  in writing that he is acquiring  such shares
for his own  account  as an  investment  and not with a view to,  or for sale in
connection with, the distribution of any thereof.

                                        3

<PAGE>



        13.  Stockholder  rights.   Neither  the  Optionee  nor  the  Optionee's
successor has any of the rights of a stockholder of the Company, with respect to
any Option Stock,  until the Company has received  payment in full of the Option
Price for that Option Stock upon exercise.

        14.  Miscellaneous.  This  Agreement  benefits  and  is  binding  on the
parties,  their  successors and assigns,  represents the entire agreement of the
parties as to its subject matter,  may be modified only in writing signed by the
parties  (except as  permitted  under  paragraph 10 of this  Agreement),  and is
governed by the laws of the state of Delaware.

Dated as of March 24, 1998.

Palatin Technologies, Inc.                   Optionee:



by___________________________               ___________________________
        Stephen T. Wills                    Charles L. Putnam
        Vice President and
        Chief Financial Officer






                                        4





                    RICHARD J. MURPHY STOCK OPTION AGREEMENT

        Palatin  Technologies,  Inc., a Delaware corporation (the "Company") and
Richard J. Murphy ("Optionee") agree:

        1. Recitals. This stock option is granted to Optionee for the purpose of
providing  compensation  to  Optionee  for  services as a member of the Board of
Directors of the Company,  the Optionee  having served as a director from August
1, 1996  until  August  26,  1997,  such  stock  option to be in lieu of the set
compensation  of $12,000 per annum due Optionee as a  non-employee  director for
services as such, and in replacement of options  heretofore  granted to Optionee
pursuant to the Company's  1996 Stock Option Plan which,  by the terms  thereof,
had  terminated  following  his  resignation  as  a  director,   and  to  be  in
satisfaction  of all such  amounts as are due and owing  Richard  J.  Murphy for
services as a director of the  Corporation.  This Richard J. Murphy Stock Option
Agreement (the "Option  Agreement")  sets forth the terms and conditions of such
grant, and is effective as of December 4, 1997.

        2. Definitions. In addition to capitalized terms defined in context, the
following capitalized terms have the following meanings in this Agreement:
        "Code"  means  the  Internal  Revenue  Code of  1986,  as  amended,  and
regulations  promulgated under the Internal Revenue Code of 1986, as amended, or
any successor legislation and regulations.
        "Committee"  means the Compensation  Committee of the Company's Board of
Directors,  or if the  Company's  Board  of  Directors  has  not  established  a
Compensation Committee, then it is the Company's Board of Directors.
        "Option  Price"  means the number of shares of Option  Stock as to which
the Option is being exercised, multiplied by the Exercise Price per share.
        "Option  Stock" means Palatin Common Stock obtained upon exercise of the
Option.
        "Palatin  Common  Stock"  means the $.01 par value  common  stock of the
Company,  or any other stock  issuable  upon  exercise of the Option as adjusted
pursuant to this  Agreement,  or as  substituted or assumed as permitted by this
Agreement.

        3. Grant of Option. Effective as of December 4, 1997, the Company grants
a  nonqualified  stock  option to Optionee to purchase  5,000  shares of Palatin
Common  Stock at a per share price of $5.44 and 1,066  shares of Palatin  Common
Stock at a per share price of $7.50 (such grant  collectively  the "Option," and
each such price an "Exercise Price").

        4.  Exercisability of Option.  The Option is immediately  exercisable by
Optionee.

        5. Exercise of Option; conditions on exercise. If the Company determines
that  exercise of the Option or issuance of Option  Stock will  violate any tax,
securities  or other law or  regulation,  then the Optionee may not exercise the
Option until the Company  determines  that the exercise or issuance  will comply
with that law or  regulation.  Otherwise,  the  Optionee may exercise all or any
part of the Option by delivering written notice directed to the Vice President


<PAGE>



and Chief Financial  Officer of the Company at the Company's  principal place of
business (214 Carnegie Center, Suite 100, Princeton,  New Jersey, 08540, or such
other  address as the Company may specify in writing to the  Optionee),  stating
the number of shares of Option  Stock which the  Optionee  intends to  purchase,
along with payment in  immediately  available U.S. funds of the Option Price for
the  number  of  shares  specified,  and the  entry by the  Optionee  into  such
arrangements  with the Company with respect to federal income tax withholding as
the  Company may  reasonably  require.  The  Company  will issue and deliver the
shares promptly upon exercise.  In lieu of issuing  fractional shares of Palatin
Common Stock, the Company will pay the Optionee cash for any fraction of a share
exercised,  at the rate of the closing  market price per share of Palatin Common
Stock on the date of exercise or last date  preceding  exercise on which Palatin
Common  Stock was  traded,  as quoted on any  national  securities  exchange  or
automated  quotation  system,  including the OTC Electronic  Bulletin  Board, on
which the Palatin Common Stock is traded.

        6. Period for exercise of Option.  The Option will be exercisable  until
December 4, 2007 (the "Final Expiration Date").

        7. Early expiration of Option in certain corporate transactions.  If the
Company  enters  into an  agreement  to engage in a  transaction  to which  Code
section 424(a) would apply if
the Option  were an  incentive  option as defined  in Code  section  422 and the
requirements rporation either substitutes a Option for or assumes the Option, or
agrees in writing to do so upon consummation of the transaction, then the Option
will expire on the earlier of (i)  consummation  of the  transaction or (ii) the
Option's original  expiration date. The Committee will give the Optionee written
notice of potential  early  expiration of the Option at least thirty days before
its potential early expiration date.

        8. Changes in Stock. If the Company's  stockholders approve an amendment
to the  Company's  certificate  of  incorporation  which effects a change in the
Palatin Common Stock or rights of Palatin Common Stock holders,  or an exchange,
reclassification  or  cancellation  of the  Palatin  Common  Stock or  rights of
Palatin Common Stock holders,  then the Committee  will  immediately  adjust the
amount  and/or  class of Option Stock and/or the Option Price so that the Option
will be exercisable at the same aggregate price as before the amendment, for the
kind and number of  securities  which the Optionee  would have been  entitled to
receive had the Optionee exercised the Option in full before the amendment.

        9.  Transferability  of  Option  and  Option  Stock.  The  Option is not
transferable otherwise than by will or the laws of descent and distribution, and
is  exercisable,  during the  Optionee's  lifetime,  only by the  Optionee.  The
Company may restrict  transferability  of Option Stock issued upon exercise,  in
order to comply,  in the Company's  judgment,  with federal and state securities
laws and/or the  requirements  of any stock exchange on which the Palatin Common
Stock is then traded.

                                        2

<PAGE>



        10.  Stockholder  rights.   Neither  the  Optionee  nor  the  Optionee's
successor has any of the rights of a stockholder of the Company, with respect to
any Option Stock,  until the Company has received  payment in full of the Option
Price for that Option Stock upon exercise.

        11. Purchase for investment and withholding. Unless the Option Shares to
be issued  upon the  exercise  of the Option  shall be  registered  prior to the
issuance  thereof under the  Securities  Act of 1933,  as amended,  the Optionee
will, as a condition of the Company's obligation to issue such Option Shares, be
required to give a  representation  in writing that he is acquiring  such shares
for his own  account  as an  investment  and not with a view to,  or for sale in
connection with, the distribution of any thereof.

        12.  Miscellaneous.  This  Agreement  benefits  and  is  binding  on the
parties,  their  successors and assigns,  represents the entire agreement of the
parties as to its subject matter,  may be modified only in writing signed by the
parties  (except as  permitted  under  paragraph  8 of this  Agreement),  and is
governed by the laws of the state of Delaware.

Dated as of December 4, 1997.

Palatin Technologies, Inc.                   Optionee:



by___________________________                ___________________________
        Stephen T. Wills                     Richard J. Murphy
        Vice President and
        Chief Financial Officer








                                        3




                 1997 EXECUTIVE OFFICERS STOCK OPTION AGREEMENT

        Palatin  Technologies,  Inc., a Delaware corporation (the "Company") and
Edward J.  Quilty,  Carl  Spana and  Charles L.  Putnam  (each  individually  an
"Optionee" and together the "Optionees") agree:

        1.  Recitals.  As of the date  hereof,  the  Board of  Directors  of the
Company approved the grant of nonqualified  stock options (each  individually an
"Option" and together the  "Options")  to Optionees to purchase  Palatin  Common
Stock (as defined in Section 2 below),  for the purpose of providing  additional
compensation  to  Optionees  and to  induce  Optionees,  who are  key  executive
officers of the  Company,  to remain in the employ and  service of the  Company.
This 1997 Executive Officers Stock Option Agreement (the "Agreement") sets forth
the terms and  conditions  of the grant of the  Options,  and is effective as of
June 3, 1997.

        2. Definitions. In addition to capitalized terms defined in context, the
following capitalized terms have the following meanings in this Agreement:
        "Committee"  means the Compensation  Committee of the Company's Board of
Directors,  or if the  Company's  Board  of  Directors  has  not  established  a
Compensation Committee, then it is the Company's Board of Directors.
        "Employee" means an employee or consultant of the Company or its present
or future subsidiaries (the "Subsidiaries").
        "Option Price" means the number of shares of Option Stock as to which an
Option is being exercised, multiplied by the Exercise Price per share.
        "Option  Stock" means Palatin  Common Stock obtained upon exercise of an
Option.
        "Palatin  Common  Stock"  means the $.01 par value  common  stock of the
Company,  or any other stock  issuable  upon  exercise of the Option as adjusted
pursuant to this  Agreement,  or as  substituted or assumed as permitted by this
Agreement.

        3. Grant of Options.  Effective as of June 3, 1997,  the Company  grants
nonqualified stock options as follows:

- - ---------------------------------------------------------------------------
                                                             EXERCISE PRICE
     OPTIONEE                    NUMBER OF SHARES              PER SHARE
- - ---------------------------------------------------------------------------
Edward J. Quilty                      49,472                     $4.96
- - ---------------------------------------------------------------------------
Carl Spana                            26,766                     $4.96
- - ---------------------------------------------------------------------------
Charles L. Putnam                     26,766                     $4.96
- - ---------------------------------------------------------------------------

The foregoing  number of shares of Palatin  Common Stock and exercise  price per
share are stated after  giving  effect to the 1-for-4  reverse  split of Palatin
Common Stock effected on September 5, 1997.



<PAGE>



        4. Exercisability of Options. The Option is exercisable by each Optionee
as follows:


Edward J. Quilty        In 17 equal monthly installments on the 16th day of each
                        month following July 1, 1997

Carl Spana              As to  one-third  of the total number of shares on  July
                        1, 1997, with an  additional  one-third  exercisable  on
                        July 1,  1998 and the  remaining  one-third  exercisable
                        on July 1, 1999

Charles L. Putnam       As to  one-third of the total number of shares  on  July
                        1,   1997,   with  an   additional one-third exercisable
                        on July 1, 1998 and the remaining  one-third exercisable
                        on July 1, 1999


The exercisability of each Option is cumulative, so that after any portion of an
Option becomes exercisable, that portion will remain exercisable until the Final
Expiration Date (as defined in Section 6 below).

        5. Exercise of Option; conditions on exercise. If the Company determines
that  exercise of an Option or issuance  of Option  Stock will  violate any tax,
securities  or other law or  regulation,  then the Optionee may not exercise the
Option until the Company  determines  that the exercise or issuance  will comply
with that law or  regulation.  Otherwise,  the  Optionee may exercise all or any
part of the  exercisable  portion  of an Option  by  delivering  written  notice
directed to the Vice President and Chief Financial Officer of the Company at the
Company's  principal  place  of  business  (214  Carnegie  Center,   Suite  100,
Princeton,  New Jersey,  08540, or such other address as the Company may specify
in writing to the Optionee),  stating the number of shares of Option Stock which
the Optionee  intends to purchase,  along with payment in immediately  available
U.S. funds of the Option Price for the number of shares specified, and the entry
by the Optionee into such  arrangements with the Company with respect to federal
income tax withholding as the Company may reasonably  require.  The Company will
issue and deliver the shares of Option Stock promptly upon exercise.  In lieu of
issuing  fractional  shares of Palatin  Common  Stock,  the Company will pay the
Optionee cash for any fraction of a share exercised,  at the rate of the closing
market  price per share of Palatin  Common Stock on the date of exercise or last
date preceding  exercise on which Palatin Common Stock was traded,  as quoted on
any national securities  exchange or automated  quotation system,  including the
OTC Electronic Bulletin Board, on which the Palatin Common Stock is traded.

        6. Period for exercise of Options. Each Option will be exercisable until
June 3, 2007 (the "Final Expiration  Date"),  subject to earlier  termination as
set forth in Section 7 below.

        7.  Termination  of employment  and Option.  A. In the event an Optionee
leaves the employ of the  Company and the  Subsidiaries  or ceases to serve as a
consultant  to the  Company,  whether  voluntarily  or  otherwise,  each  Option
theretofore granted to him which shall not have theretofore expired or otherwise
been canceled shall, to the extent not theretofore exercised, terminate upon the
earlier to occur of the expiration of 90 days after the date of such Optionee's

                                        2

<PAGE>



termination   of   employment  or  service  and  the  Final   Expiration   Date.
Notwithstanding the foregoing, if a Optionee's employment by the Company and the
Subsidiaries  or service as a consultant is  terminated  for "cause" (as defined
herein), each Option theretofore granted to him which shall not have theretofore
expired  or  otherwise  been  canceled  shall,  to the  extent  not  theretofore
exercised, terminate forthwith.

        B. For purposes of the  foregoing,  the term "cause" shall mean: (i) the
commission by an Optionee of any act or omission  that would  constitute a crime
under  federal,  state or  equivalent  foreign law,  (ii) the  commission  by an
Optionee of any act of moral turpitude, (iii) fraud, dishonesty or other acts or
omissions that result in a breach of any fiduciary or other material duty to the
Company and/or the  Subsidiaries  or (iv) continued  alcohol or other  substance
abuse that renders an Optionee  incapable of performing  his material  duties to
the satisfaction of the Company and/or the Subsidiaries.

        8. Adjustment of Number of Shares. A. In the event that a dividend shall
be declared upon the Palatin  Common Stock  payable in shares of Palatin  Common
Stock,  the number of shares of Palatin  Common Stock then subject to any Option
shall be  adjusted  by adding to each share the number of shares  which would be
distributable  thereon if such shares had been outstanding on the date fixed for
determining the  stockholders  entitled to receive such stock  dividend.  In the
event that the outstanding  shares of Palatin Common Stock shall be changed into
or  exchanged  for a  different  number  or kind of  shares  of  stock  or other
securities  of  the  Company  or  of  another   corporation,   whether   through
reorganization, recapitalization, stock split-up, combination of shares, sale of
assets,   merger  or  consolidation  in  which  the  Company  is  the  surviving
corporation,  then there shall be  substituted  for each share of Palatin Common
Stock then subject to any Option the number and kind of shares of stock or other
securities into which each outstanding share of Palatin Common Stock shall be so
changed or for which each such share shall be exchanged.

        B. In the event that there shall be any change,  other than as specified
in this section,  in the number or kind of outstanding  shares of Palatin Common
Stock, or of any stock or other securities into which Palatin Common Stock shall
have been  changed,  or for which it shall  have been  exchanged,  then,  if the
Committee  shall, in its sole  discretion,  determine that such change equitably
requires  an  adjustment  in the  number or kind of shares  then  subject to any
Option,  such  adjustment  shall be made by the Committee and shall be effective
and binding for all purposes.

        C. No  adjustment  or  substitution  provided for in this section  shall
require the Company to sell a fractional share.

        D. In the event of the  dissolution or liquidation of the Company,  or a
merger,  reorganization  or  consolidation  in  which  the  Company  is not  the
surviving corporation, then, except as otherwise provided in the second sentence
of subsection A above,  each Option,  to the extent not  theretofore  exercised,
shall terminate forthwith.


                                        3

<PAGE>


        9.  Transferability  of  Option  and  Option  Stock.  The  Option is not
transferable otherwise than by will or the laws of descent and distribution, and
is  exercisable,  during the  Optionee's  lifetime,  only by the  Optionee.  The
Company may restrict  transferability  of Option Stock issued upon exercise,  in
order to comply,  in the Company's  judgment,  with federal and state securities
laws and/or the  requirements  of any stock exchange on which the Palatin Common
Stock is then traded.

        10. Purchase for investment and withholding. Unless the Option Shares to
be issued  upon the  exercise  of the Option  shall be  registered  prior to the
issuance  thereof under the  Securities  Act of 1933,  as amended,  the Optionee
will, as a condition of the Company's obligation to issue such Option Shares, be
required to give a  representation  in writing that he is acquiring  such shares
for his own  account  as an  investment  and not with a view to,  or for sale in
connection with, the distribution of any thereof.

        11.  Stockholder  rights.   Neither  the  Optionee  nor  the  Optionee's
successor has any of the rights of a stockholder of the Company, with respect to
any Option Stock,  until the Company has received  payment in full of the Option
Price for that Option Stock upon exercise.

        12.  Miscellaneous.  This  Agreement  benefits  and  is  binding  on the
parties,  their  successors and assigns,  represents the entire agreement of the
parties as to its subject matter,  may be modified only in writing signed by the
parties (except as permitted under Section 8 of this Agreement), and is governed
by the laws of the state of Delaware.

Dated as of June 3, 1997.

Palatin Technologies, Inc.                        Optionee:


by___________________________                     ___________________________
        Stephen T. Wills                          Edward J. Quilty
        Vice President and
        Chief Financial Officer
                                                  ___________________________
                                                  Carl Spana


                                                  ___________________________
                                                  Charles L. Putnam






                                        4



              [Letterhead of Rubin Baum Levin Constant & Friedman]


                                  June 17, 1998

BY MAIL

Palatin Technologies, Inc.
214 Carnegie Center, Suite 100
Princeton, NJ 08540


        RE:     REGISTRATION  OF SHARES  OF COMMON  STOCK  OFFERED  PURSUANT  TO
                EMPLOYEE BENEFIT PLANS

Ladies and Gentlemen:

        We have  acted as  counsel to  Palatin  Technologies,  Inc.,  a Delaware
corporation  (the  "Company"),   in  connection  with  the  preparation  of  its
Registration Statement on Form S-8 under the Securities Act of 1933, as amended,
to be filed with the  Securities  and  Exchange  Commission  (the  "Registration
Statement"),  to  which  this  opinion  is  to  be  filed  as  an  exhibit.  The
Registration  Statement  relates  to  the  issuance  of up to  an  aggregate  of
1,271,341  shares (the "Shares") of the Company's  common stock,  par value $.01
per share ("Common  Stock"),  pursuant to stock options  granted or which may be
granted under the following employee benefit plans (the "Plans"):

        (1)    RhoMed Incorporated 1987 Employee Incentive Stock Option Plan;
        (2)    RhoMed Incorporated 1987 Nonqualified Stock Option Plan;
        (3)    RhoMed Incorporated 1995 Employee Incentive Stock Option Plan;
        (4)    RhoMed Incorporated 1995 Nonqualified Stock Option Plan;
        (5)    Palatin Technologies, Inc. 1996 Stock Option Plan;
        (6)    Edward J. Quilty Employment Agreement;
        (7)    Carl Spana Stock Option Agreement;
        (8)    Charles L. Putnam Stock Option Agreement;
        (9)    Richard J. Murphy Stock Option Agreement; and
        (10)   1997 Executive Officers Stock Option Agreement.

        Based  solely  on the  foregoing,  and  having  regard  for  such  legal
considerations  as we deem relevant,  we are of the opinion that the Shares have


                                        

<PAGE>

Palatin Technologies, Inc.
June 17, 1998
Page 2



been duly authorized for issuance under the Plans,  and the Shares,  when issued
and paid for in accordance  with the terms and conditions of the Plans,  against
payment therefor,  will be legally issued,  fully paid and  nonassessable.  This
opinion  is limited to matters  of  Federal  and  Delaware  law,  and we make no
representations as to the effect of the laws of other jurisdictions.

        We hereby  consent to the filing of this opinion with the Securities and
Exchange Commission as an exhibit to the Registration  Statement. In giving this
consent,  we do not thereby  admit that we are in the category of persons  whose
consent is required  under Section 7 of the  Securities Act of 1933, as amended,
and  the  rules  and  regulations  of the  Securities  and  Exchange  Commission
thereunder.  Reference  is made to the  section  of the  Registration  Statement
entitled "Interests of Named Experts and Counsel" for a description of ownership
of the Company's securities by certain attorneys of this firm.

                                    Very truly yours


                                    RUBIN BAUM LEVIN CONSTANT & FRIEDMAN


                                            




                         CONSENT OF INDEPENDENT AUDITORS

As independent  public  accountants,  we hereby consent to the  incorporation by
reference  in this  registration  statement  of our report dated August 20, 1997
included in Palatin Technologies, Inc.'s Form 10-KSB for the year ended June 30,
1997 and to all references to our firm included in this registration statement.


Philadelphia, Pa.,
    June 17, 1998





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