TRIMERIS INC
4, 1999-10-12
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                                     FORM 4



                     U.S. SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                  STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP

                       Filed pursuant to Section 16(a) of
                         the Securities Exchange Act of
                           1934, Section 17(a) of the
                   Public Utility Holding Company Act of 1935
             or Section 30(f) of the Investment Company Act of 1940

/  / Check this box if no longer subject to Section 16.
Form 4 or Form 5 obligations may continue.
See Instruction 1(b).



1.   Name and Address of Reporting Person*:

         Four Partners
         ------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         c/o Thomas J. Tisch
         667 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99

<PAGE>


5.   If Amendment, Date of Original:

      (Month/Year)



6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director

         _____  Officer (give title below)

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value ("Common Stock")
         Common Stock
         Common Stock
         Common Stock
         Common Stock
         Common Stock
         Common Stock

2.   Transaction Date:

      (Month/Day/Year)

         9/27/99
         9/27/99
         9/28/99
         9/28/99
         9/29/99
         9/30/99
         9/30/99




                                        2
<PAGE>


3.   Transaction Code:

      (Instr. 8)



      Code

         P
         P
         P
         P
         P
         P
         P

4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price

                    6,500       A              18.16                    9/27/99
                  120,000       A              18.19                    9/27/99
                   80,000       A              17.75                    9/28/99
                   10,000       A              18.18                    9/28/99
                   17,000       A              17.00                    9/29/99
                   30,000       A              16.04                    9/30/99
                   16,000       A              16.65                    9/30/99


5.   Amount of Securities Beneficially Owned at End of Month:

      (Instr. 3 and 4)

        609,200



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         D



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)




                                        3
<PAGE>


Reminder:   Report on a  separate  line for each class of  securities
            beneficially owned directly or indirectly.



*  If the form is filed by more than one reporting person,
   see Instruction 4(b)(v).

           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:





3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:

      (Instr. 8)

      Code




                                        4
<PAGE>



5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)



       (A)                 (D)



6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date





7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares





8.   Price of Derivative Security:

      (Instr. 5)



9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)





10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)




                                        5
<PAGE>


11.  Nature of Indirect Beneficial Ownership:

       (Instr. 4)



Explanation of Responses:

              This Form 4 is being filed jointly by the following individuals
              and entities:

              1. Four Partners, a New York general partnership ("FP");

              2. Thomas J. Tisch;

              3. Daniel R. Tisch;

              4. James S. Tisch;

              5. Andrew H. Tisch (Thomas J. Tisch, Daniel R. Tisch, James S.
         Tisch and Andrew H. Tisch are referred to collectively as the "Messrs.
         Tisch");

              6. The Thomas J. Tisch 1999 Annuity Trust IV ("Thomas Tisch
         GRAT IV");

              7. The Daniel R. Tisch 1999 Annuity Trust IV ("Daniel Tisch
         GRAT IV");

              8. The James S. Tisch 1999 Annuity Trust IV ("James Tisch
         GRAT IV");

              9. The Andrew H. Tisch 1999 Annuity Trust IV ("Andrew Tisch
         GRAT IV"; and collectively with Thomas Tisch GRAT IV, Daniel Tisch
         GRAT IV and James Tisch GRAT IV, the "GRATs IV").

              10. The Thomas J. Tisch 1999 Annuity Trust VII ("Thomas Tisch
         GRAT VII");

              11. The Daniel R. Tisch 1999 Annuity Trust VII ("Daniel Tisch
         GRAT VII");

              12. The James S. Tisch 1999 Annuity Trust VII ("James Tisch
         GRAT VII"); and

              13. The Andrew H. Tisch 1999 Annuity Trust VII ("Andrew Tisch
         GRAT VII"; and collectively with the GRATs IV, Thomas Tisch GRAT VII,
         Daniel Tisch GRAT VII and James Tisch GRAT VII, the "GRATs").




                                        6
<PAGE>

     FP, the Messrs. Tisch and the GRATs are referred to herein individually as
a "Reporting Person" and collectively as the "Reporting Persons."

     The sole partners of FP are Andrew H. Tisch 1991 Trust, for which Andrew H.
Tisch is the managing trustee, Daniel R. Tisch 1991 Trust, for which Daniel R.
Tisch is the managing trustee, James S. Tisch 1991 Trust, for which James S.
Tisch is the managing trustee, and Thomas J. Tisch 1991 Trust, for which Thomas
J. Tisch is the managing trustee. Thomas J. Tisch has been appointed the Manager
of FP.

     Each of the GRATs is a grantor retained annuity Trust in which the grantor
holds an annuity interest and in which the remainder interest was created in
favor of a trust or trusts for the grantor's offspring. Thomas J. Tisch is the
grantor and Andrew H. Tisch is the trustee of Thomas Tisch GRAT IV. Daniel R.
Tisch is the grantor and James S. Tisch is the trustee of Daniel Tisch GRAT IV.
James S. Tisch is the grantor and Thomas J. Tisch is the trustee of James Tisch
GRAT IV. Andrew H. Tisch is the grantor and Daniel R. Tisch is the trustee of
Andrew Tisch GRAT IV. Thomas J. Tisch is the grantor and Andrew H. Tisch is the
trustee of Thomas Tisch GRAT VII. Daniel R. Tisch is the grantor and James S.
Tisch is the trustee of Daniel Tisch GRAT VII. James S. Tisch is the grantor and
Thomas J. Tisch is the trustee of James Tisch GRAT VII. Andrew H. Tisch is the
grantor and Daniel R. Tisch is the trustee of Andrew Tisch GRAT VII.

     Each of the Messrs. Tisch is herein reporting indirect beneficial ownership
of the shares of common stock, $.001 par value ("Common Stock"), of Trimeris,
Inc. (the "Issuer") owned by the GRATs for which he is the grantor. The shares
of Common Stock reported herein as beneficially owned by each of the Messrs.
Tisch do not include shares owned by FP.The filing of this statement is not an
admission by any Reporting Person that such Reporting Person and any other
person or persons constitute a "group" for purposes of Section 13(d)(3) of the
Securities Exchange Act of 1934, as amended, or Rule 13d-5 thereunder or that
any Reporting Person is the beneficial owner of any securities owned by any
other person.





                   [Signatures follow all attachments]




                                        7
<PAGE>

                      Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99



Joint Filer Information

1.   Name and Address of Reporting Person*:

         Thomas J. Tisch
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         667 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)





6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director




                                        8
<PAGE>

         _____  Officer (give title below)

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code



4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:




                                        9
<PAGE>

      (Instr. 3 and 4)

         288,325



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         D



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)



           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:





3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:

      (Instr. 8)




                                       10
<PAGE>

      Code





5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)



       (A)                 (D)



6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date

7.   Title and Amount of Underlying Securities:



       (Instr. 3 and 4)

      Title                Amount or Number of Shares



8.   Price of Derivative Security:

      (Instr. 5)



9.   Number of Derivative Securities Beneficially Owned at End of Month:
      (Instr. 4)



10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)



11.  Nature of Indirect Beneficial Ownership:




                                       11
<PAGE>

       (Instr. 4)

Explanation of Responses:

See Form 4 of FP

[Signatures follow all attachments]




                                       12
<PAGE>

                      Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99



Joint Filer Information

1.   Name and Address of Reporting Person*:

         Daniel R. Tisch
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         c/o Mentor Partners, LP
         499 Park Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10022
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)





6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director




                                       13
<PAGE>

         _____  Officer (give title below)

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code



4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:




                                       14
<PAGE>

      (Instr. 3 and 4)

         288,325



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         D



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)



           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:





3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:

      (Instr. 8)




                                       15
<PAGE>

      Code





5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)



       (A)                 (D)





6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date



7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares



8.   Price of Derivative Security:

      (Instr. 5)



9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)



10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)




                                       16
<PAGE>



11.  Nature of Indirect Beneficial Ownership:

       (Instr. 4)



Explanation of Responses:

See Form 4 of FP

[Signatures follow all attachments]





                                       17
<PAGE>

                      Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99



Joint Filer Information

1.   Name and Address of Reporting Person*:

         James S. Tisch
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         667 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ----------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)





6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director




                                       18
<PAGE>

         _____  Officer (give title below)

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code



4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:




                                       19
<PAGE>

      (Instr. 3 and 4)

         288,325



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         D



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)



           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:





3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:

      (Instr. 8)




                                       20
<PAGE>

      Code





5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)



       (A)                 (D)





6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date







7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares




8.   Price of Derivative Security:

      (Instr. 5)



9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)




                                       21
<PAGE>




10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)





11.  Nature of Indirect Beneficial Ownership:

       (Instr. 4)

Explanation of Responses:

[Signatures follow all attachments]




                                       22
<PAGE>


                      Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99



Joint Filer Information

1.   Name and Address of Reporting Person*:

         Andrew H. Tisch
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         667 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)





6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director




                                       23
<PAGE>

         _____  Officer (give title below)

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code



4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:




                                       24
<PAGE>

      (Instr. 3 and 4)

         288,325



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         D



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)





           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:





3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:




                                       25
<PAGE>

      (Instr. 8)

      Code





5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)



       (A)                 (D)





6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date



7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares




8.   Price of Derivative Security:

      (Instr. 5)



9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)




                                       26
<PAGE>




10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)



11.  Nature of Indirect Beneficial Ownership:

       (Instr. 4)

Explanation of Responses:

[Signatures follow all attachments]







                                       27
<PAGE>

                     Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99



Joint Filer Information

1.   Name and Address of Reporting Person*:

         The Thomas J. Tisch 1999 Annuity Trust IV
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         c/o Mr. Barry Bloom
         665 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)



6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director

         _____  Officer (give title below)




                                       28
<PAGE>

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code



4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:

      (Instr. 3 and 4)




                                       29
<PAGE>

         38,325



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         D



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)



           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:



3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:

      (Instr. 8)

      Code




                                       30
<PAGE>


5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

       (A)                 (D)



6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date



7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares





8.   Price of Derivative Security:

      (Instr. 5)



9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)



10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)



11.  Nature of Indirect Beneficial Ownership:

       (Instr. 4)




                                       31
<PAGE>


Explanation of Responses:

[Signatures follow all attachments]








                                       32
<PAGE>

                      Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99



Joint Filer Information

1.   Name and Address of Reporting Person*:

         The Daniel R. Tisch 1999 Annuity Trust IV
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         c/o Mr. Barry Bloom
         665 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)





6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director




                                       33
<PAGE>

         _____  Officer (give title below)

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code



4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:




                                       34
<PAGE>

      (Instr. 3 and 4)

         38,325



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         D



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)



           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:





3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:

      (Instr. 8)




                                       35
<PAGE>

      Code





5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)



       (A)                 (D)





6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date



7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares



8.   Price of Derivative Security:

      (Instr. 5)



9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)



10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)




                                       36
<PAGE>


11.  Nature of Indirect Beneficial Ownership:

       (Instr. 4)



Explanation of Responses:

See Form 4 of FP

[Signatures follow all attachments]





                                       37
<PAGE>


                      Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99



Joint Filer Information

1.   Name and Address of Reporting Person*:

         The James S. Tisch 1999 Annuity Trust IV
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         c/o Thomas J. Tisch
         665 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)





6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director




                                       38
<PAGE>

         _____  Officer (give title below)

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code



4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:




                                       39
<PAGE>

      (Instr. 3 and 4)

         38,325



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         D



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)



           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:





3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:

      (Instr. 8)




                                       40
<PAGE>

      Code





5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)



       (A)                 (D)





6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date







7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares





8.   Price of Derivative Security:

      (Instr. 5)



9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)




                                       41
<PAGE>




10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)





11.  Nature of Indirect Beneficial Ownership:

       (Instr. 4)

Explanation of Responses:

[Signatures follow all attachments]







                                       42
<PAGE>

                      Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99



Joint Filer Information

1.   Name and Address of Reporting Person*:

         The Andrew H. Tisch 1999 Annuity Trust IV
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         c/o Mr. Barry Bloom
         665 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)





6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director




                                       43
<PAGE>

         _____  Officer (give title below)

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code



4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:




                                       44
<PAGE>

      (Instr. 3 and 4)

         38,325



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         D



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)





           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:





3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:




                                       45
<PAGE>

      (Instr. 8)

      Code





5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)



       (A)                 (D)





6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date



7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares





8.   Price of Derivative Security:

      (Instr. 5)



9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)




                                       46
<PAGE>




10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)



11.  Nature of Indirect Beneficial Ownership:

       (Instr. 4)

Explanation of Responses:

[Signatures follow all attachments]







                                       47
<PAGE>

                      Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99



Joint Filer Information

1.   Name and Address of Reporting Person*:

         The Thomas J. Tisch 1999 Annuity Trust VII
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         c/o Mr. Barry Bloom
         665 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)



6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director

         _____  Officer (give title below)




                                       48
<PAGE>

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code



4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:

      (Instr. 3 and 4)




                                       49
<PAGE>

         250,000



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         D



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)



           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:



3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:

      (Instr. 8)

      Code




                                       50
<PAGE>


5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

       (A)                 (D)



6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date



7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares





8.   Price of Derivative Security:

      (Instr. 5)



9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)



10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)



11.  Nature of Indirect Beneficial Ownership:

       (Instr. 4)




                                       51
<PAGE>



Explanation of Responses:

[Signatures follow all attachments]






                                       52
<PAGE>

                     Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99



Joint Filer Information

1.   Name and Address of Reporting Person*:

         The Daniel R. Tisch 1999 Annuity Trust VII
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         c/o Mr. Barry Bloom
         665 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)





6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director




                                       53
<PAGE>

         _____  Officer (give title below)

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code




4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:




                                       54
<PAGE>

      (Instr. 3 and 4)

         250,000



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         I



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)

         (See explanation to Form 4 of FP)



           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:



3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:

      (Instr. 8)




                                       55
<PAGE>

      Code



5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)



       (A)                 (D)



6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date



7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares



8.   Price of Derivative Security:

      (Instr. 5)


9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)



10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)



11.  Nature of Indirect Beneficial Ownership:




                                       56
<PAGE>

       (Instr. 4)

Explanation of Responses:

[Signatures follow all attachments]






                                       57
<PAGE>


                      Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99


Joint Filer Information

1.   Name and Address of Reporting Person*:

         The James S. Tisch 1999 Annuity Trust VII
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         c/o Thomas J. Tisch
         665 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)



6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director

         _____  Officer (give title below)




                                       58
<PAGE>

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code



4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:

      (Instr. 3 and 4)




                                       59
<PAGE>

         250,000



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         I



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)

         (See explanation to Form 4 of FP)



           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:





3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:

      (Instr. 8)




                                       60
<PAGE>

      Code





5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)



       (A)                 (D)



6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date



7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares



8.   Price of Derivative Security:

      (Instr. 5)


9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)



10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)




                                       61
<PAGE>


11.  Nature of Indirect Beneficial Ownership:

       (Instr. 4)

Explanation of Responses:

[Signatures follow all attachments]






                                       62
<PAGE>

                     Attachment To Form 4 of Four Partners
                       in Respect of Trimeris, Inc. (TRMS)
                               Statement for: 9/99



Joint Filer Information

1.   Name and Address of Reporting Person*:

         The Andrew H. Tisch 1999 Annuity Trust VII
         ------------------------------------------
         (LAST)        (FIRST)   (MIDDLE)

         c/o Mr. Barry Bloom
         665 Madison Avenue
         -------------------------------------------
         (STREET)

         New York,       New York          10021
         ------------------------------------------
         (CITY)        (STATE)           (ZIP)



2.   Issuer Name and Ticker or Trading Symbol:

         Trimeris, Inc. (TRMS)



3.   IRS Identification Number of Reporting Person, if an entity  (Voluntary):



4.   Statement for Month/Year:

         9/99



5.   If Amendment, Date of Original:

      (Month/Year)



6.   Relationship of Reporting Person(s) to Issuer:     (Check all applicable)

         _____  Director

         _____  Officer (give title below)




                                       63
<PAGE>

         __X__  10% Owner

         _____  Other (specify below)



7.   Individual or Joint/Group Filing (Check Applicable Line)

         _____  Form filed by One Reporting Person

         _X___  Form filed by More than One Reporting Person



                  Table I - Non-Derivative Securities Acquired,
                       Disposed of, or Beneficially Owned



1.   Title of Security:

      (Instr. 3)

         Common Stock, $0.001 par value



2.   Transaction Date:

      (Month/Day/Year)



3.   Transaction Code:

      (Instr. 8)

      Code



4.   Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)

      Amount       (A) or (D)               Price



5.   Amount of Securities Beneficially Owned at End of Month:

      (Instr. 3 and 4)




                                       64
<PAGE>

         250,000



6.   Ownership Form:   Direct (D) or Indirect (I):

      (Instr. 4)

         I



7.   Nature of Indirect Beneficial Ownership:

      (Instr. 4)

         (See explanation to Form 4 of FP)



           Table II - Derivative Securities Acquired, Disposed of, or
            Beneficially Owned (e.g., puts, calls, warrants, options,
                             convertible securities)





1.   Title of Derivative Security:

      (Instr. 3)





2.   Conversion or Exercise Price of Derivative Security:





3.   Transaction Date:

      (Month/Day/Year)





4.   Transaction Code:

      (Instr. 8)




                                       65
<PAGE>

      Code





5.   Number of Derivative Securities Acquired (A) or Disposed of (D):

      (Instr. 3, 4 and 5)



       (A)                 (D)



6.    Date Exercisable and Expiration Date:

       (Month/Day/Year)



       Date Exercisable             Expiration Date



7.   Title and Amount of Underlying Securities:

       (Instr. 3 and 4)



      Title                Amount or Number of Shares



8.   Price of Derivative Security:

      (Instr. 5)



9.   Number of Derivative Securities Beneficially Owned at End of Month:

      (Instr. 4)



10.  Ownership Form of Derivative Security:   Direct (D) or Indirect (I):

       (Instr. 4)




                                       66
<PAGE>


11.  Nature of Indirect Beneficial Ownership:

       (Instr. 4)



Explanation of Responses:

[Signatures follow all attachments]




                                       67
<PAGE>




                                   SIGNATURE
                                   ---------



     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


                                   FOUR PARTNERS

                                   By /s/ Thomas J. Tisch
                                      ------------------------
                                      Thomas J. Tisch, Manager

                                      /s/ Andrew H. Tisch
                                   -------------------------------
                                      Andrew H. Tisch

                                      /s/ Daniel R. Tisch
                                   -------------------------------
                                      Daniel R. Tisch

                                      /s/ James S. Tisch
                                   -------------------------------
                                      James S. Tisch

                                      /s/ Thomas J. Tisch
                                   -------------------------------
                                      Thomas J. Tisch

                                    THE ANDREW H. TISCH 1999 ANNUITY TRUST IV

                                       /s/ Daniel R. Tisch
                                     -------------------------------
                                       Daniel R. Tisch, Trustee

                                    THE DANIEL R. TISCH 1999 ANNUITY TRUST IV

                                    By  /s/ James S. Tisch
                                      -------------------------------
                                        James S. Tisch, Trustee




                                       68
<PAGE>

                                     THE JAMES S. TISCH 1999 ANNUITY TRUST IV

                                     By  /s/ Thomas J. Tisch
                                       -------------------------------
                                         Thomas J. Tisch, Trustee

                                     THE THOMAS J. TISCH 1999 ANNUITY TRUST IV

                                     By  /s/ Andrew H. Tisch
                                       -------------------------------
                                         Andrew H. Tisch, Trustee

                                     THE ANDREW H. TISCH 1999 ANNUITY TRUST VII

                                     By  /s/ Daniel R. Tisch
                                       -------------------------------
                                         Daniel R. Tisch, Trustee

                                     THE DANIEL R. TISCH 1999 ANNUITY TRUST VII

                                      By  /s/ James S. Tisch
                                        -------------------------------
                                          James S. Tisch, Trustee

                                      THE JAMES S. TISCH 1999 ANNUITY TRUST VII

                                      By  /s/ Thomas J. Tisch
                                        -------------------------------
                                          Thomas J. Tisch, Trustee

                                      THE THOMAS J. TISCH 1999 ANNUITY TRUST VII

                                      By  /s/ Andrew H. Tisch
                                        -------------------------------
                                          Andrew H. Tisch, Trustee

Date: October 12, 1999

** Intentional misstatements or omissions of facts constitute Federal Criminal
Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).

Note: File three copies of the Form, one of which must be manually signed. If
space provided is insufficient, see Instruction 6 for procedure.

Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently
valid OMB Number.




                                       69
<PAGE>


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