TRIMERIS INC
8-K, 2000-02-04
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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________________________________________________________________________________

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  ____________


                                    FORM 8-K


                 CURRENT REPORT PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                                  ____________


             Date of Report                       Commission File Number 0-23155
  (Date of earliest  event  reported)
            January 28, 2000


                                 TRIMERIS, INC.
                           (Exact name of registrant)


       Delaware                                     56-1808663
  (State of organization)               (I.R.S. Employer Identification Number)


         4727 University Drive, Suite 100, Durham, North Carolina 27707
             (Address of principal executive offices and zip code)

                                 (919) 419-6050
                         (Registrant's telephone Number)





________________________________________________________________________________


<PAGE>


ITEM 5.  OTHER EVENTS

         Pursuant to the terms and conditions of the form of Purchase  Agreement
filed as Exhibit 99 to this  Current  Report,  Trimeris,  Inc.  closed a private
placement of 1,750,000 shares of common stock to new and current shareholders at
a price per share of $40.50.


ITEM 7.  EXHIBITS

         Exhibit No.
         -----------

           99       Form of Purchase Agreement dated as of January 28, 2000 by
                    and between Trimeris, Inc. and the Purchasers set forth on
                    the signature page thereto.


<PAGE>

                                    SIGNATURE
                                    ---------


                  Pursuant to the requirements of the Securities Exchange Act of
1934,  the  registrant has duly caused this report to be signed on its behalf by
the undersigned hereunto duly authorized.


                                    TRIMERIS, INC.



                                    By: /s/ Dani P. Bolognesi
                                       _________________________________
                                       Dani P. Bolognesi
                                       Chief Executive Officer and
                                       Chief Scientific Officer



Dated:  February 3, 2000



Exhibit No. 99
- --------------


                               PURCHASE AGREEMENT


         THIS PURCHASE AGREEMENT (this "Agreement") is made as of the 28th day
of January, 2000, by and among Trimeris, Inc., a Delaware corporation (the
"Company"), and the purchaser whose name and address is set forth on the
signature page hereof (the "Investor").

1.       Authorization and Sale of the Shares.  Subject to the terms and
conditions of this Agreement, the Company has authorized the issuance and sale
of up to 1,750,000 shares (the "Shares") of the common stock, par value $.001
per share (the "Common Stock"), of the Company to certain investors in a private
placement (the "Offering"). The Company reserves the right to increase or
decrease the number of Shares offered and sold in the Offering prior to the
Closing Date (as defined below).

2.       Agreement to Sell and Purchase the Shares; Subscription Date.

2.1      At the Closing (as  defined in Section 3 hereof),  the Company  will
sell to the Investor, and the Investor will purchase from the Company, upon the
terms and conditions hereinafter set forth, the number of Shares set forth on
the signature page hereto at the purchase price set forth on such signature
page. If the Closing Date has not occurred, the Company's obligation to sell and
the Investor's obligation to purchase the Shares will expire on February 15,
2000.

2.2      The Company proposes to enter into this same form of Purchase Agreement
with certain other investors (the "Other Investors") and expects to complete
sales of Shares to them. (The Investor and the Other Investors are hereinafter
sometimes collectively referred to as the "Investors," and this Agreement and
the Purchase Agreements executed by the Other Investors are hereinafter
sometimes collectively referred to as the "Agreements.") The Company will accept
executed Agreements from Investors for the purchase of Shares commencing upon
the date on which the Company provides the Investors with the proposed purchase
price per Share and concluding upon the date (the "Subscription Date") on which
the Company has notified Deutsche Bank Securities Inc. (in its capacity as
Placement Agent for the Shares, the "Placement Agent") in writing that it is no
longer accepting Agreements from Investors for the purchase of Shares.

2.3      Investor acknowledges that the Company intends to pay the Placement
Agent a fee in respect of the sale of Shares to the Investor.

3.       Delivery of the Shares at Closing. The completion of the purchase and
sale of the Shares (the "Closing") shall occur at a place and time (the "Closing
Date") to be specified by the Company and the Placement Agent, and of which the
Investors will be notified in advance by the Placement Agent. At the Closing,
each Investor shall make payment for the Shares to the Company or its order by
wire transfer of federal funds to the account specified by the Company. Such
payment shall be made upon delivery of certificates for the Shares to the
respective accounts of the Investors representing the number of Shares set forth
on the signature page hereto, each such certificate to be registered in the name
of the Investor or, if so indicated on the signature page hereto, in the name of
a nominee designated by the Investor.

The Company's obligation to issue the Shares to the Investor shall be subject to
the following conditions, any one or more of which may be waived by the Company:
(a) receipt by the Company of the purchase price for the Shares being  purchased
hereunder as set forth on the signature page hereto; (b) completion

                                       2
<PAGE>

of purchases and sales in an aggregate amount of not less than 1,000,000 Shares
under this Agreement and the Agreements with the Other Investors; and (c) the
accuracy of the representations and warranties made by the Investors and the
fulfillment of those undertakings of the Investors to be fulfilled prior to the
Closing.

The Investor's obligation to purchase the Shares shall be subject to the
accuracy of the representations and warranties made by the Company and the
fulfillment of those undertakings of the Company to be fulfilled prior to the
Closing. The Investor's obligations are expressly not conditioned on the
purchase by any or all of the other Investors of the Shares that they have
agreed to purchase from the Company.

4.       Representations, Warranties and Covenants of the Company. The Company
hereby represents and warrants to, and covenants with, the Investor, as follows:

4.1      Organization. The Company is duly incorporated and validly existing and
in good standing under the laws of the jurisdiction of its organization. The
Company has full power and authority to own, operate and occupy its properties
and to conduct its business as presently conducted and as described in the
Exchange Act Documents (as defined below) and is registered or qualified to do
business and in good standing in each jurisdiction in which it owns or leases
property or transacts business and where the failure to be so qualified would
have a material adverse effect upon the business, financial condition,
properties or operations of the Company ("Material Adverse Effect"), and no
proceeding has been instituted in any such jurisdiction revoking, limiting or
curtailing, or seeking to revoke, limit or curtail, such power and authority or
qualification.

4.2      Due Authorization. The Company has all requisite power and authority
to execute, deliver and perform its obligations under the Agreements, and the
Agreements have been duly authorized and validly executed and delivered by the
Company and constitute legal, valid and binding agreements of the Company
enforceable against the Company in accordance with their terms, except as rights
to indemnity and contribution may be limited by state or federal securities laws
or the public policy underlying such laws, except as enforceability may be
limited by applicable bankruptcy, insolvency, reorganization, moratorium or
similar laws affecting creditors' and contracting parties' rights generally and
except as enforceability may be subject to general principles of equity
(regardless of whether such enforceability is considered in a proceeding in
equity or at law).

4.3      Non-Contravention. The execution and delivery of the Agreements, the
issuance and sale of the Shares to be sold by the Company under the Agreements,
the fulfillment of the terms of the Agreements and the consummation of the
transactions contemplated thereby will not (A) conflict with or constitute a
violation of, or default (with the passage of time or otherwise) under, (i) any
material bond, debenture, note or other evidence of indebtedness, or any
material lease, contract, indenture, mortgage, deed of trust, loan agreement,
joint venture or other agreement or instrument to which the Company is a party
or by which it or its properties are bound, (ii) the charter, by-laws or other
organizational documents of the Company, or (iii) any law, administrative
regulation, ordinance or order of any court or governmental agency, arbitration
panel or authority binding upon the Company or its properties, where such
conflict, violation or default is likely to result in a Material Adverse Effect,
or (B) result in the creation or imposition of any material lien, encumbrance,
claim, security interest or restriction whatsoever upon any of the material
properties or assets of the Company or a material acceleration of indebtedness
pursuant to any obligation, agreement or condition contained in any material
bond, debenture, note or any other material evidence of indebtedness or any
material indenture, mortgage, deed of trust or any other material agreement or
instrument to which the Company is a party or by which any of them is bound or
to which any of the material property or assets of the Company is subject. No
consent, approval, authorization or other order of, or registration,
qualification or filing with, any regulatory body, administrative agency, or
other governmental body in the United States is required for the execution and
delivery of the Agreements and the valid issuance and sale of the Shares to be
sold pursuant to the Agreements, other than such as have been made or obtained,
except for any securities filings required to be made under

                                       3
<PAGE>

federal or state securities laws, and except where any failure to obtain any of
the foregoing would not have a Material Adverse Effect.

4.4      Capitalization. The capitalization of the Company as of January 25,
2000 is as follows (excluding unvested options and treasury shares): preferred
stock, $.001 par value, 10,000,000 shares authorized, no shares issued and
outstanding; Common Stock, 30,000,000 shares authorized, 13,782,071 shares
issued and outstanding; 1,696,382 shares of Common Stock reserved for issuance
pursuant to outstanding stock options; 502,044 shares of Common Stock reserved
for future issuance under the Company's stock option plan and stock purchase
plan; and 373,734 shares of Common Stock reserved for issuance pursuant to
outstanding warrants. The Company has not issued any capital stock since that
date other than pursuant to the Company's employee benefit plans. The Shares to
be sold pursuant to the Agreements have been duly authorized, and when issued
and paid for in accordance with the terms of the Agreements, will be duly and
validly issued, fully paid and nonassessable. The outstanding shares of capital
stock of the Company have been duly and validly issued and are fully paid and
nonassessable, have been issued in compliance with all federal and state
securities laws, and were not issued in violation of any preemptive rights or
similar rights to subscribe for or purchase securities. Except as set forth in
or contemplated by the Exchange Act Documents, there are no outstanding rights
(including, without limitation, preemptive rights), warrants or options to
acquire, or instruments convertible into or exchangeable for, any unissued
shares of capital stock or other equity interest in the Company, or any
contract, commitment, agreement, understanding or arrangement of any kind to
which the Company is a party and relating to the issuance or sale of any capital
stock of the Company, any such convertible or exchangeable securities or any
such rights, warrants or options. Without limiting the foregoing and other than
certain registration rights previously granted by the Company to certain Company
shareholders which may (under certain circumstances) delay the registration of
the Investors' Shares, no preemptive right, co-sale right, right of first
refusal or other similar right exists with respect to the issuance and sale of
the Shares. The Company has no subsidiaries (as defined in Rule 405 under the
Securities Act of 1933, as amended (the "Securities Act")) and does not own,
directly or indirectly, any equity interest in any firm, partnership, joint
venture, association or other entity. Except as disclosed in the Exchange Act
Documents, there are no stockholders agreements, voting agreements or other
similar agreements with respect to the Common Stock to which the Company is a
party.

4.5      Legal Proceedings. There is no material legal or governmental
proceeding pending to which the Company or any Subsidiary is a party or of which
the business or property of the Company is subject that is not disclosed in the
Exchange Act Documents.

4.6      No Violations. The Company is not in violation of its charter, bylaws
or other organizational document, or in violation of any law, administrative
regulation, ordinance or order of any court or governmental agency, arbitration
panel or authority applicable to the Company, which violation, individually or
in the aggregate, would be reasonably likely to have a Material Adverse Effect,
or is in default (and there exists no condition which, with the passage of time
or otherwise, would constitute a default) in the performance of any material
bond, debenture, note or any other evidence of indebtedness, or in any
indenture, mortgage, deed of trust or any other material agreement or instrument
to which the Company is a party or by which the Company is bound or by which its
properties are bound, which would be reasonably likely to have a Material
Adverse Effect.

4.7      Governmental Permits, Etc. The Company has all necessary franchises,
licenses, certificates and other authorizations from any foreign, federal, state
or local government or governmental agency, department or body that are
currently necessary for the operation of the business of the Company as
currently conducted except where the failure to currently possess could not
reasonably be expected to have a Material Adverse Effect.

                                       4
<PAGE>

4.8      Intellectual Property. Except as set forth in the Company's Form 10-Q
for the quarter ended March 31, 1999 under the caption "Risk Factors -- There is
uncertainty regarding patents and proprietary rights,"

(a)      The Company has  exclusive  ownership or a valid  license to use all
patent, copyright, trade secret, trademark or other proprietary rights that are
used in the business of the Company and are material to the Company
(collectively, "Intellectual Property"). All of such material patents,
registered trademarks and registered copyrights have been duly registered in,
filed in or issued by the United States Patent and Trademark Office, the United
States Register of Copyrights or the corresponding offices of other
jurisdictions and have been maintained and renewed in accordance with all
applicable provisions of law and administrative regulations in the United States
and all such jurisdictions.

(b)      All  material  licenses  or other  material  agreements  under which
(i) the Company is granted rights in Intellectual Property and (ii) the Company
has granted rights to others in Intellectual Property owned or licensed by the
Company, are in full force and effect and there is no material default by the
Company thereto.

(c)      No  proceedings  have been  instituted or are pending  which  challenge
in a material manner the rights of the Company in respect to the Company's right
to the use of the Intellectual Property. The Company has the right to use, free
and clear of material claims or rights of other persons, all of its customer
lists, designs, computer software, systems, data compilations, and other
information that are required for its products or its business as presently
conducted.

(d)      The Company  believes it has taken such reasonable  steps as are
required in accordance with sound business practice and business judgment to
establish and preserve its ownership of all material copyright, trade secret and
other proprietary rights with respect to its products and technology.

(e)      To the knowledge of the Company, the present business, activities and
products of the Company do not infringe any intellectual property of any other
person, except where such infringement would not have a Material Adverse Effect
on the Company. No material proceeding charging the Company with infringement of
any adversely held Intellectual Property has been filed. To the Company's
knowledge, there exists no third party unexpired patent or patent application
which includes claims that would be infringed by, or otherwise have a Material
Adverse Effect on the business activities or products of the Company. To the
knowledge of the Company, the Company is not making unauthorized use of any
material confidential information or trade secrets of any third party. To the
Company's knowledge, the activities of the Company or any of its employees on
behalf of the Company do not violate any material agreements or arrangements
known to the Company which any such employees have with other persons, if any.

4.9      Financial Statements. The financial statements of the Company and the
related notes contained in the Exchange Act Documents present fairly, in
accordance with generally accepted accounting principles, the financial position
of the Company as of the dates indicated, and the results of its operations and
cash flows for the periods therein specified. Such financial statements
(including the related notes) have been prepared in accordance with generally
accepted accounting principles applied on a consistent basis throughout the
periods therein specified, except as may be disclosed in the Exchange Act
Documents.

4.10     No Material Adverse Change. Since September 30, 1999, (i) there has not
been any Material Adverse Effect affecting the Company, (ii) any obligation,
direct or contingent, that is material to the Company, incurred by the Company,
except obligations incurred in the ordinary course of business, (iii) any
dividend or distribution of any kind declared, paid or made on the capital stock
of the Company, or (iv) any loss or damage (whether or not insured) to the
physical property of the Company which has been sustained which has a Material
Adverse Effect.

                                       5
<PAGE>

4.11     Disclosure. The information contained in the Exchange Act Documents as
of the date of such information did not contain an untrue statement of a
material fact or omit to state a material fact required to be stated therein or
necessary to make the statements therein, in light of the circumstances under
which they were made, not misleading.

4.12     Nasdaq Compliance. The Company's Common Stock is registered pursuant to
Section 12(g) of the Exchange Act (as defined in Section 4.13) and is listed on
the Nasdaq National Market of the Nasdaq Stock Market (the "Nasdaq Stock
Market"), and the Company has taken no action designed to, or likely to have the
effect of, terminating the registration of the Common Stock under the Exchange
Act or de-listing the Common Stock from the Nasdaq Stock Market, nor has the
Company received any notification that the Securities and Exchange Commission
(the "SEC") or the National Association of Securities Dealers, Inc. ("NASD") is
contemplating terminating such registration or listing.

4.13     Reporting Status. The Company has filed in a timely manner all
documents that the Company was required to file under the Securities Exchange
Act of 1934, as amended (the "Exchange Act"), during the 12 months preceding the
date of this Agreement. The following documents complied in all material
respects with the SEC's requirements as of their respective filing dates, and
the information contained therein as of the date thereof did not contain an
untrue statement of a material fact or omit to state a material fact required to
be stated therein or necessary to make the statements therein in light of the
circumstances under where they were made not misleading:

         (a)      Quarterly Report on Form 10-Q for the Quarter Ended September
                  30, 1999, filed with the SEC on November 15, 1999;

         (b)      Quarterly Report on Form 10-Q for the Quarter Ended June 30,
                  1999, filed with the SEC on August 13, 1999;

         (c)      Quarterly Report on Form 10-Q for the Quarter Ended March 31,
                  1999, filed with the SEC on May 17, 1999;

         (d)      Annual Report on Form 10-K for the Year Ended December 31,
                  1998, filed with the SEC on March 31, 1999;

         (e)      Definitive Proxy Statement filed with the SEC on April 30,
                  1999; and

         (f)      All other documents, if any, filed by the Company with the SEC
                  since December 31, 1998 pursuant to the reporting requirements
                  of the Exchange Act (collectively, the "Exchange Act
                  Documents").

4.14     Listing. The Company shall use its reasonable best efforts to comply
with all requirements of the NASD with respect to the issuance of the Shares and
the listing thereof on the Nasdaq Stock Market.

4.15     No Manipulation of Stock. The Company has not taken and will not, in
violation of applicable law, take, any action designed to or that might
reasonably be expected to cause or result in manipulation of the price of the
Common Stock to facilitate the sale or resale of the Shares.

4.16     Accountants. KPMG LLP, who the Company expects will express their
opinion with respect to the financial statements to be incorporated by reference
from the Company's Annual Report on Form 10-K for the year ended December 31,
1999 into the Registration Statement (as defined below) and the Prospectus which
forms a part thereof, are independent accountants as required by the Securities
Act and the rules and regulations promulgated thereunder (the "Rules and
Regulations").

                                       6
<PAGE>

4.17     Contracts. The contracts described in the Exchange Act Documents or
incorporated by reference therein that are material to the Company are in full
force and effect on the date hereof, and neither the Company nor, to the
Company's knowledge, any other party to such contracts is in breach of or
default under any of such contracts which would have a Material Adverse Effect.

4.18     Properties. The Company has good and marketable title to all the
properties and assets reflected as owned by it in the financial statements
included in or incorporated by reference into the Exchange Act Documents,
subject to no lien, mortgage, pledge, charge or encumbrance of any kind except
(i) those, if any, reflected in such financial statements, (ii) those of the
United States Government to exercise rights with respect to inventions made with
Government support, or (iii) those which are not material in amount and do not
adversely affect the use made and promised to be made of such property by the
Company. The Company holds its leased properties under valid and binding leases,
with such exceptions as are not materially significant in relation to their
respective businesses. Except as disclosed in the Exchange Act Documents, the
Company owns or leases all such properties as are necessary to its operations as
now conducted.

4.19     Taxes. The Company has filed all necessary federal, state and foreign
income and franchise tax returns and has paid or accrued all taxes shown as due
thereon, and the Company has no knowledge of a tax deficiency which has been or
might be asserted or threatened against it which would have a Material Adverse
Effect.

4.20     Transfer Taxes. On the Closing Date, all stock transfer or other taxes
(other than income taxes) which are required to be paid in connection with the
sale and transfer of the Shares to be sold to the Investor hereunder will be, or
will have been, fully paid or provided for by the Company and all laws imposing
such taxes will be or will have been fully complied with.

4.21     Investment Company. The Company is not an "investment company" or an
"affiliated person" of, or "promoter" or "principal underwriter" for an
investment company, within the meaning of the Investment Company Act of 1940, as
amended.

4.22     Offering Materials. Other than the Exchange Act Documents and the press
release dated January 28, 2000 relating to the clinical progress of the
Company's investigational drugs (the "Offering Materials"), the Company has not
distributed and will not distribute prior to the Closing Date any offering
material in connection with the offering and sale of the Shares. The Company has
not in the past nor will it hereafter take any action independent of the
Placement Agent to sell, offer for sale or solicit offers to buy any securities
of the Company which would bring the offer, issuance or sale of the Shares, as
contemplated by this Agreement, within the provisions of Section 5 of the
Securities Act, unless such offer, issuance or sale was or shall be within the
exemptions of Section 4 of the Securities Act.

4.23     Insurance. The Company maintains and will continue to maintain
insurance of the types and in the amounts that the Company reasonably believes
is adequate for its business, including, but not limited to, insurance covering
all real and personal property owned or leased by the Company against theft,
damage, destruction, acts of vandalism and all other risks customarily insured
against by similarly situated companies, all of which insurance is in full force
and effect.

4.24     Contributions. The Company has not at any time since its incorporation,
directly or indirectly, (i) made any unlawful contribution to any candidate for
public office, or failed to disclose fully any contribution in violation of law,
or (ii) made any payment to any federal or state governmental officer or
official, or other person charged with similar public or quasi-public duties,
other than payments required or permitted by the laws of the United States or
any jurisdiction thereof.

4.25     Legal Opinion. The Company shall cause to be delivered to the Investors
and the Placement Agent by counsel to the Company a customary legal opinion
pertaining to Rule 10b-5 under the

                                       7
<PAGE>

Securities Exchange Act of 1934 and to the availability of an exemption from the
registration provisions of the Securities Act.

5.       Representations, Warranties and Covenants of the Investor.

5.1      The Investor represents and warrants to, and covenants with, the
Company that: (i) the Investor is an "accredited investor" as defined in
Regulation D under the Securities Act and the Investor is also knowledgeable,
sophisticated and experienced in making, and is qualified to make decisions with
respect to, investments in shares presenting an investment decision like that
involved in the purchase of the Shares, including investments in securities
issued by the Company and investments in comparable companies, and has
requested, received, reviewed and considered all information it deemed relevant
in making an informed decision to purchase the Shares; (ii) the Investor is
acquiring the number of Shares set forth on the signature page hereto in the
ordinary course of its business and for its own account for investment only and
with no present intention of distributing any of such Shares and no arrangement
or understanding exists with any other person regarding the distribution of such
Shares; (iii) the Investor will not, directly or indirectly, offer, sell,
pledge, transfer or otherwise dispose of (or solicit any offers to buy, purchase
or otherwise acquire or take a pledge of) any of the Shares except in compliance
with the Securities Act, applicable state securities laws and the respective
rules and regulations promulgated thereunder; (iv) the Investor has answered all
questions on the signature page hereto for use in preparation of the
Registration Statement (as defined in Section 7.1) and the answers thereto are
true and correct as of the date hereof and will be true and correct as of the
Closing Date; (v) the Investor will notify the Company immediately of any change
in any of such information until such time as the Investor has sold all of its
Shares or until the Company is no longer required to keep the Registration
Statement effective; and (vi) the Investor has, in connection with its decision
to purchase the number of Shares set forth on the signature page hereto, relied
only upon the Offering Materials and the representations and warranties of the
Company contained herein. Investor understands that its acquisition of the
Shares has not been registered under the Securities Act or registered or
qualified under any state securities law in reliance on specific exemptions
therefrom, which exemptions may depend upon, among other things, the bona fide
nature of the Investor's investment intent as expressed herein. Investor has
completed or caused to be completed and delivered to the Company the Investor
Questionnaire attached as Exhibit A hereto, which questionnaire is true and
correct in all material respects.

5.2      The Investor acknowledges, represents and agrees that no action has
been or will be taken in any jurisdiction outside the United States by the
Company or the Placement Agent that would permit an offering of the Shares, or
possession or distribution of offering materials in connection with the issue of
the Shares, in any jurisdiction outside the United States where action for that
purpose is required. Each Investor outside the United States will comply with
all applicable laws and regulations in each foreign jurisdiction in which it
purchases, offers, sells or delivers Shares or has in its possession or
distributes any offering material, in all cases at its own expense. The
Placement Agent is not authorized to make any representation or use any
information in connection with the issue, placement, purchase and sale of the
Shares other than as contained in the Offering Materials.

5.3      The Investor hereby covenants with the Company not to make any sale of
the Shares without complying with the provisions of this Agreement, including
Section 7.2 hereof, and without effectively causing the prospectus delivery
requirement under the Securities Act to be satisfied, and the Investor
acknowledges that the certificates evidencing the Shares will be imprinted with
a legend that prohibits their transfer except in accordance therewith. The
Investor acknowledges that there may occasionally be times when the Company,
based on the advice of its counsel, determines that it must suspend the use of
the Prospectus forming a part of the Registration Statement until such time as
an amendment to the Registration Statement has been filed by the Company and
declared effective by the SEC or until the Company has amended or supplemented
such Prospectus.

                                       8
<PAGE>

5.4      The Investor further represents and warrants to, and covenants with,
the Company that (i) the Investor has full right, power, authority and capacity
to enter into this Agreement and to consummate the transactions contemplated
hereby and has taken all necessary action to authorize the execution, delivery
and performance of this Agreement, and (ii) this Agreement constitutes a valid
and binding obligation of the Investor enforceable against the Investor in
accordance with its terms, except as enforceability may be limited by applicable
bankruptcy, insolvency, reorganization, moratorium or similar laws affecting
creditors' and contracting parties' rights generally and except as
enforceability may be subject to general principles of equity (regardless of
whether such enforceability is considered in a proceeding in equity or at law)
and except as the indemnification agreements of the Investors herein may be
legally unenforceable.

5.5      Investor will not, prior to the effectiveness of the Registration
Statement, sell, offer to sell, solicit offers to buy, dispose of, loan, pledge
or grant any right with respect to (collectively, a "Disposition"), the Shares
if doing so would be in violation of applicable securities laws, nor will
Investor engage in any hedging or other transaction which is designed to or
could reasonably be expected to lead to or result in a Disposition of the Shares
by the Investor or any other person or entity. Such prohibited hedging or other
transactions would include, without limitation, effecting any short sale or
having in effect any short position (whether or not such sale or position is
against the box and regardless of when such position was entered into) or any
purchase, sale or grant of any right (including, without limitation, any put or
call option) with respect to the Shares or with respect to any security (other
than a broad-based market basket or index) that includes or derives any
significant part of its value from the Shares.

5.6      The Investor understands that nothing in this Agreement or any other
materials presented to the Investor in connection with the purchase and sale of
the Shares constitutes legal, tax or investment advice. The Investor has
consulted such legal, tax and investment advisors as it, in its sole discretion,
has deemed necessary or appropriate in connection with its purchase of Shares.

6.        Survival of Representations, Warranties and Agreements.
Notwithstanding any investigation made by any party to this Agreement or by the
Placement Agent, all covenants, agreements, representations and warranties made
by the Company and the Investor herein shall survive the execution of this
Agreement, the delivery to the Investor of the Shares being purchased and the
payment therefor.

7.       Registration of the Shares; Compliance with the Securities Act.

7.1      Registration Procedures and Expenses.  The Company shall:

    (a) prepare and file with the SEC, within 30 days after the Closing Date, a
    registration statement on Form S-3 (the "Registration Statement"), to enable
    the resale of the Shares by the Investors from time to time through the
    automated quotation system of the Nasdaq Stock Market or in
    privately-negotiated transactions;

    (b) use its  reasonable  best  efforts,  subject  to  receipt  of  necessary
    information  from the  Investors,  to cause the  Registration  Statement  to
    become effective as soon as practicable, but in no event later than 120 days
    after the Closing Date;

    (c) use its  reasonable  best  efforts to prepare and file with the SEC such
    amendments and supplements to the Registration  Statement and the Prospectus
    used in  connection  therewith as may be necessary to keep the  Registration
    Statement current and effective for a period not exceeding,  with respect to
    each Investor's  Shares purchased  hereunder,  the earlier of (i) the second
    anniversary  of the Closing  Date,  (ii) the date on which the  Investor may
    sell all Shares then held by the Investor without  restriction by the volume
    limitations of Rule 144(e) of the Securities  Act, or (iii) such time as all
    Shares  purchased by such  Investor in this Offering have been sold pursuant
    to a registration statement;

                                       9
<PAGE>

    (d) furnish to the Investor with respect to the Shares  registered under the
    Registration Statement such number of copies of the Registration  Statement,
    Prospectuses   and   Preliminary   Prospectuses   in  conformity   with  the
    requirements  of the Securities Act and such other documents as the Investor
    may  reasonably  request,  in order to  facilitate  the public sale or other
    disposition of all or any of the Shares by the Investor,  provided, however,
    that the  obligation  of the Company to deliver  copies of  Prospectuses  or
    Preliminary  Prospectuses to the Investor shall be subject to the receipt by
    the Company of  reasonable  assurances  from the Investor  that the Investor
    will comply with the applicable provisions of the Securities Act and of such
    other  securities or blue sky laws as may be  applicable in connection  with
    any use of such Prospectuses or Preliminary Prospectuses;

    (e) file documents  required of the Company for normal blue sky clearance in
    states  specified in writing by the Investor,  provided,  however,  that the
    Company  shall not be  required  to  qualify  to do  business  or consent to
    service of process in any  jurisdiction  in which it is not now so qualified
    or has not so consented;

    (f) bear all expenses in  connection  with the  procedures  in paragraph (a)
    through (e) of this Section 7.1 and the  registration of the Shares pursuant
    to the Registration Statement; and

    (g) advise the  Investors,  promptly after it shall receive notice or obtain
    knowledge  of the  issuance  of  any  stop  order  by the  SEC  delaying  or
    suspending  the  effectiveness  of  the  Registration  Statement  or of  the
    initiation of any proceeding for that purpose;  and it will promptly use its
    reasonable  efforts to prevent  the  issuance of any stop order or to obtain
    its withdrawal at the earliest  possible moment if such stop order should be
    issued.

    (h) With a view to making available to the Investor the benefits of Rule 144
    (or its successor rule) and any other rule or regulation of the SEC that may
    at any time  permit  the  Investor  to sell  Shares  to the  public  without
    registration,  the Company covenants and agrees to: (i) make and keep public
    information  available,  as those terms are  understood  and defined in Rule
    144, until the earlier of (A) such date as all of the Investor's  Shares may
    be resold pursuant to Rule 144(k) or any other rule of similar effect or (B)
    such date as all of the Investor's Shares shall have been resold;  (ii) file
    with the SEC in a timely manner all reports and other documents  required of
    the Company under the  Securities  Act and under the Exchange Act; and (iii)
    furnish to the  Investor  upon  request,  as long as the  Investor  owns any
    Shares, (A) a written statement by the Company that it has complied with the
    reporting  requirements  of the  Securities  Act and the Exchange Act, (B) a
    copy of the  Company's  most recent  Annual Report on Form 10-K or Quarterly
    Report on Form 10-Q,  and (C) such other  information  as may be  reasonably
    requested  in order to avail the Investor of any rule or  regulation  of the
    SEC that permits the selling of any such Shares without registration.

The Company  understands that the Investor  disclaims being an underwriter,  but
the  Investor  being  deemed an  underwriter  by the SEC shall not  relieve  the
Company of any  obligations it has  hereunder,  provided,  however,  that if the
Company  receives  notification  from the SEC that the  Investor  is  deemed  an
underwriter,  then the  period by which the  Company is  obligated  to submit an
acceleration request to the SEC shall be extended to the earlier of (i) the 90th
day after such SEC  notification,  or (ii) 150 days after the initial  filing of
the Registration Statement with the SEC.

7.2      Transfer of Shares After Registration; Suspension.

(a)      The Investor agrees that it will not effect any Disposition of the
Shares or its right to purchase the Shares that would constitute a sale within
the meaning of the Securities Act except as contemplated in the Registration
Statement referred to in Section 7.1 and as described below, and that it will
promptly notify the Company of any changes in the information set forth in the
Registration Statement regarding the Investor or its plan of distribution.

                                       10
<PAGE>
(b)      Except in the event that paragraph (c) below applies, the Company
shall: (i) if deemed necessary by the Company, prepare and file from time to
time with the SEC a post-effective amendment to the Registration Statement or a
supplement to the related Prospectus or a supplement or amendment to any
document incorporated therein by reference or file any other required document
so that such Registration Statement will not contain an untrue statement of a
material fact or omit to state a material fact required to be stated therein or
necessary to make the statements therein not misleading, and so that, as
thereafter delivered to purchasers of the Shares being sold thereunder, such
Prospectus will not contain an untrue statement of a material fact or omit to
state a material fact required to be stated therein or necessary to make the
statements therein, in light of the circumstances under which they were made,
not misleading; (ii) provide the Investor copies of any documents filed pursuant
to Section 7.2(b)(i); and (iii) inform each Investor that the Company has
complied with its obligations in Section 7.2(b)(i) (or that, if the Company has
filed a post-effective amendment to the Registration Statement which has not yet
been declared effective, the Company will notify the Investor to that effect,
will use its reasonable efforts to secure the effectiveness of such
post-effective amendment as promptly as possible and will promptly notify the
Investor pursuant to Section 7.2(b)(i) hereof when the amendment has become
effective).

(c)      Subject to paragraph (d) below, in the event: (i) of any request by the
SEC or any other federal or state governmental authority during the period of
effectiveness of the Registration Statement for amendments or supplements to a
Registration Statement or related Prospectus or for additional information; (ii)
of the issuance by the SEC or any other federal or state governmental authority
of any stop order suspending the effectiveness of a Registration Statement or
the initiation of any proceedings for that purpose; (iii) of the receipt by the
Company of any notification with respect to the suspension of the qualification
or exemption from qualification of any of the Shares for sale in any
jurisdiction or the initiation of any proceeding for such purpose; or (iv) of
any event or circumstance which necessitates the making of any changes in the
Registration Statement or Prospectus, or any document incorporated or deemed to
be incorporated therein by reference, so that, in the case of the Registration
Statement, it will not contain any untrue statement of a material fact or any
omission to state a material fact required to be stated therein or necessary to
make the statements therein not misleading, and that in the case of the
Prospectus, it will not contain any untrue statement of a material fact or any
omission to state a material fact required to be stated therein or necessary to
make the statements therein, in the light of the circumstances under which they
were made, not misleading; then the Company shall deliver a certificate in
writing to the Investor (the "Suspension Notice") to the effect of the foregoing
and, upon receipt of such Suspension Notice, the Investor will refrain from
selling any Shares pursuant to the Registration Statement (a "Suspension") until
the Investor's receipt of copies of a supplemented or amended Prospectus
prepared and filed by the Company, or until it is advised in writing by the
Company that the current Prospectus may be used, and has received copies of any
additional or supplemental filings that are incorporated or deemed incorporated
by reference in any such Prospectus. In the event of any Suspension, the Company
will use its reasonable efforts to cause the use of the Prospectus so suspended
to be resumed as soon as reasonably practicable.

(d)      Provided that a Suspension is not then in effect, the Investor may sell
Shares under the Registration Statement, provided that it arranges for delivery
of a current Prospectus to the transferee of such Shares (or arranges for
delivery of such to the transferee's broker). Upon receipt of a written request
therefor, the Company has agreed to provide an adequate number of current
Prospectuses to the Investor and to supply copies to any other parties requiring
such Prospectuses.

(e)      In the event of a sale of Shares by the Investor, the Investor must
also deliver to the Company's transfer agent, with a copy to the Company, a
Certificate of Subsequent Sale substantially in the form attached as Exhibit B
hereto, so that the Shares may be properly transferred.

7.3      Indemnification.  For the purpose of this Section 7.3: (i) the term
"Selling Stockholder" shall include the Investor and any officer, director, each
person who controls such Investor within the meaning of Section 15 of the
Securities Act, or affiliate of such Investor; (ii) the term "Registration
Statement"
                                       11
<PAGE>
shall include any final Prospectus, exhibit, supplement or amendment included in
or relating to the Registration Statement referred to in Section 7.1; and (iii)
the term "untrue statement" shall include any untrue statement or alleged untrue
statement, or any omission or alleged omission to state in the Registration
Statement a material fact required to be stated therein or necessary to make the
statements therein, in the light of the circumstances under which they were
made, not misleading.

    (a) The Company agrees to indemnify and hold harmless each Selling
    Stockholder from and against any losses, claims, damages or liabilities to
    which such Selling Stockholder may become subject (under the Securities Act
    or otherwise) insofar as such losses, claims, damages or liabilities (or
    actions or proceedings in respect thereof) arise out of, or are based upon
    (i) any untrue statement of a material fact contained in the Registration
    Statement, or (ii) any failure by the Company to fulfill any undertaking
    included in the Registration Statement, and the Company will reimburse such
    Selling Stockholder for any reasonable legal or other expenses reasonably
    incurred in investigating, defending or preparing to defend any such action,
    proceeding or claim; provided, however, that the Company shall not be liable
    in any such case to the extent that such loss, claim, damage or liability
    arises out of, or is based upon, an untrue statement made in such
    Registration Statement in reliance upon and in conformity with written
    information furnished to the Company by or on behalf of such Selling
    Stockholder or the failure of such Selling Stockholder to comply with its
    covenants and agreements contained in Sections 5 or 7.2 hereof or any
    statement or omission in any Prospectus that is corrected in any subsequent
    Prospectus that was delivered to the Investor prior to the pertinent sale or
    sales by the Investor.

    (b) The Investor agrees to severally indemnify and hold harmless the Company
    (and each person, if any, who controls the Company within the meaning of
    Section 15 of the Securities Act, each officer of the Company who signs the
    Registration Statement and each director of the Company) from and against
    any losses, claims, damages or liabilities to which the Company (or any such
    officer, director or controlling person) may become subject (under the
    Securities Act or otherwise), insofar as such losses, claims, damages or
    liabilities (or actions or proceedings in respect thereof) arise out of, or
    are based upon, (i) any failure to comply with the covenants and agreements
    contained in Sections 5 or 7.2 hereof, or (ii) any untrue statement of a
    material fact contained in the Registration Statement if such untrue
    statement was made in reliance upon and in conformity with written
    information furnished by or on behalf of the Investor, and the Investor will
    reimburse the Company (or such officer, director or controlling person), as
    the case may be, for any legal or other expenses reasonably incurred in
    investigating, defending or preparing to defend any such action, proceeding
    or claim.

    (c) Promptly after receipt by any indemnified person of a notice of a claim
    or the beginning of any action in respect of which indemnity is to be sought
    against an indemnifying person pursuant to this Section 7.3, such
    indemnified person shall notify the indemnifying person in writing of such
    claim or of the commencement of such action, but the omission to so notify
    the indemnifying party will not relieve it from any liability which it may
    have to any indemnified party under this Section 7.3 (except to the extent
    that such omission materially and adversely affects the indemnifying party's
    ability to defend such action) or from any liability otherwise than under
    this Section 7.3. Subject to the provisions hereinafter stated, in case any
    such action shall be brought against an indemnified person, the indemnifying
    person shall be entitled to participate therein, and, to the extent that it
    shall elect by written notice delivered to the indemnified party promptly
    after receiving the aforesaid notice from such indemnified party, shall be
    entitled to assume the defense thereof, with counsel reasonably satisfactory
    to such indemnified person. After notice from the indemnifying person to
    such indemnified person of its election to assume the defense thereof, such
    indemnifying person shall not be liable to such indemnified person for any
    legal expenses subsequently incurred by such indemnified person in
    connection with the defense thereof, provided, however, that if there exists
    or shall exist a conflict of interest that would make it inappropriate, in
    the reasonable opinion of counsel to the indemnified person, for the same
    counsel to represent both the indemnified person and such indemnifying
    person or any affiliate or associate thereof, the indemnified person shall
    be entitled to                     12
<PAGE>
    retain its own counsel at the reasonable expense of such indemnifying
    person; provided, however, that no indemnifying person shall be responsible
    for the fees and expenses of more than one separate counsel (together with
    appropriate local counsel) for all indemnified parties. In no event shall
    any indemnifying person be liable in respect of any amounts paid in
    settlement of any action unless the indemnifying person shall have approved
    the terms of such settlement; provided that such consent shall not be
    unreasonably withheld. No indemnifying person shall, without the prior
    written consent of the indemnified person, effect any settlement of any
    pending or threatened proceeding in respect of which any indemnified person
    is or could have been a party and indemnification could have been sought
    hereunder by such indemnified person, unless such settlement includes an
    unconditional release of such indemnified person from all liability on
    claims that are the subject matter of such proceeding.

    (d) If the indemnification provided for in this Section 7.3 is unavailable
    to or insufficient to hold harmless an indemnified party under subsection
    (a) or (b) above in respect of any losses, claims, damages or liabilities
    (or actions or proceedings in respect thereof) referred to therein, then
    each indemnifying party shall contribute to the amount paid or payable by
    such indemnified party as a result of such losses, claims, damages or
    liabilities (or actions in respect thereof) in such proportion as is
    appropriate to reflect the relative fault of the Company on the one hand and
    the Investors on the other in connection with the statements or omissions or
    other matters which resulted in such losses, claims, damages or liabilities
    (or actions in respect thereof), as well as any other relevant equitable
    considerations. The relative fault shall be determined by reference to,
    among other things, in the case of an untrue statement, whether the untrue
    statement relates to information supplied by the Company on the one hand or
    an Investor on the other and the parties' relative intent, knowledge, access
    to information and opportunity to correct or prevent such untrue statement.
    The Company and the Investors agree that it would not be just and equitable
    if contribution pursuant to this subsection (d) were determined by pro rata
    allocation (even if the Investors were treated as one entity for such
    purpose) or by any other method of allocation which does not take into
    account the equitable considerations referred to above in this subsection
    (d). The amount paid or payable by an indemnified party as a result of the
    losses, claims, damages or liabilities (or actions in respect thereof)
    referred to above in this subsection (d) shall be deemed to include any
    legal or other expenses reasonably incurred by such indemnified party in
    connection with investigating or defending any such action or claim.
    Notwithstanding the provisions of this subsection (d), no Investor shall be
    required to contribute any amount in excess of the amount by which the gross
    amount received by the Investor from the sale of the Shares to which such
    loss relates exceeds the amount of any damages which such Investor has
    otherwise been required to pay by reason of such untrue statement. No person
    guilty of fraudulent misrepresentation (within the meaning of Section 11(f)
    of the Securities Act) shall be entitled to contribution from any person who
    was not guilty of such fraudulent misrepresentation. The Investors'
    obligations in this subsection to contribute are several in proportion to
    their sales of Shares to which such loss relates and not joint.

    (e) The parties to this Agreement hereby acknowledge that they are
    sophisticated business persons who were represented by counsel during the
    negotiations regarding the provisions hereof including, without limitation,
    the provisions of this Section 7.3, and are fully informed regarding said
    provisions. They further acknowledge that the provisions of this Section 7.3
    fairly allocate the risks in light of the ability of the parties to
    investigate the Company and its business in order to assure that adequate
    disclosure is made in the Registration Statement as required by the Act and
    the Exchange Act. The parties are advised that federal or state public
    policy as interpreted by the courts in certain jurisdictions may be contrary
    to certain of the provisions of this Section 7.3, and the parties hereto
    hereby expressly waive and relinquish any right or ability to assert such
    public policy as a defense to a claim under this Section 7.3 and further
    agree not to attempt to assert any such defense.

7.4      Termination of Conditions and Obligations. The conditions precedent
imposed by Section 5 or this Section 7 upon the transferability of the Shares
shall cease and terminate as to any particular number

                                       13
<PAGE>

of the Shares when such Shares shall have been effectively registered under the
Securities Act and sold or otherwise disposed of in accordance with the intended
method of disposition set forth in the Registration Statement covering such
Shares or at such time as an opinion of counsel satisfactory to the Company
shall have been rendered to the effect that such conditions are not necessary in
order to comply with the Securities Act.

8.       Notices. All notices, requests, consents and other communications
hereunder shall be in writing, shall be mailed (A) if within domestic United
States by first-class registered or certified airmail, or nationally recognized
overnight express courier, postage prepaid, or by facsimile, or (B) if delivered
from outside the United States, by International Federal Express or facsimile,
and shall be deemed given (i) if delivered by first-class registered or
certified mail domestic, three business days after so mailed, (ii) if delivered
by nationally recognized overnight carrier, one business day after so mailed,
(iii) if delivered by International Federal Express, two business days after so
mailed, (iv) if delivered by facsimile, upon electric confirmation of receipt
and shall be delivered as addressed as follows:

                           (a)      if to the Company, to:
                                    Trimeris, Inc.
                                    4727 University Drive, Suite 100
                                    Durham, North Carolina 27707
                                    Attn:  Dr. Dani P. Bolognesi
                                    Phone:  919-419-6050
                                    Telecopy:  919-419-1816

                           (b)      with a copy mailed to:
                                    Wilmer, Cutler & Pickering
                                    2445 M Street, N.W.
                                    Washington, D.C. 20037
                                    Attn:  John B. Watkins, Esq.
                                    Phone:  202-663-6000
                                    Telecopy:  202-663-6363

                           (c)      if to the Investor, at its address on the
signature page hereto, or at such other address or addresses as may have been
furnished to the Company in writing in accordance with this Section 8.

9.       Changes.  This Agreement may not be modified or amended except pursuant
to an instrument in writing signed by the Company and the Investor.

10.      Headings.  The headings of the various sections of this Agreement have
been inserted for convenience of reference only and shall not be deemed to be
part of this Agreement.

11.      Severability.  In case any provision contained in this Agreement should
be invalid, illegal or unenforceable in any respect, the validity, legality and
enforceability of the remaining provisions contained herein shall not in any way
be affected or impaired thereby.

12.      Governing  Law. This Agreement shall be governed by, and construed in
accordance with, the laws of the State of New York, without giving effect to any
choice of law provisions thereof, and the federal law of the United States of
America.

13.      Counterparts.  This Agreement may be executed in two or more
counterparts, each of which shall constitute an original, but all of which, when
taken together, shall constitute but one instrument.

                                       14
<PAGE>

IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed
by their duly-authorized representatives shown below.

                                  ______________________________________________
                                  "INVESTOR"

                                  By: __________________________________________

                                  Print Name: __________________________________

                                  Title: _______________________________________

                                  Address: _____________________________________

                                  ______________________________________________

                                  Number of Shares: ____________________________

                                  Aggregate Purchase Price $____________________

                                  Tax ID No.: __________________________________

                                  Contact name: ________________________________

                                  Telephone: ___________________________________

                                  Name in which shares should be
                                  registered (if different): ___________________


Accepted and Agreed to by :
                                  TRIMERIS, INC.

                                  By:      ____________________

                                  Title:   ____________________

                                  Date:    ____________________



                                       15
<PAGE>
                                                                       Exhibit A
                                                                       ---------
                                 TRIMERIS, INC.

                             INVESTOR QUESTIONNAIRE

                (ALL INFORMATION WILL BE TREATED CONFIDENTIALLY)

To:     Trimeris, Inc.

This  Investor  Questionnaire   ("Questionnaire")  must  be  completed  by  each
potential  investor in  connection  with the offer and sale of the shares of the
common stock, par value $.001 per share, of Trimeris,  Inc. (the "Shares").  The
Shares are being  offered and sold by Trimeris,  Inc.  (the  "Company")  without
registration  under the  Securities  Act of 1933,  as amended  (the  "Securities
Act"), and the securities laws of certain states,  in reliance on the exemptions
contained in Section 4(2) of the  Securities Act and on Regulation D promulgated
thereunder and in reliance on similar  exemptions  under  applicable state laws.
The Company must determine that a potential  investor meets certain  suitability
requirements before offering or selling Shares to such investor.  The purpose of
this  Questionnaire  is to assure the Company that each  investor  will meet the
applicable  suitability  requirements.  The information  supplied by you will be
used in  determining  whether  you meet such  criteria,  and  reliance  upon the
private  offering   exemptions  from  registration  is  based  in  part  on  the
information herein supplied.

This  Questionnaire does not constitute an offer to sell or a solicitation of an
offer to buy any  security.  Your  answers will be kept  strictly  confidential.
However, by signing this  Questionnaire,  you will be authorizing the Company to
provide a completed  copy of this  Questionnaire  to such parties as the Company
deems  appropriate in order to ensure that the offer and sale of the Shares will
not result in a violation of the Securities  Act or the  securities  laws of any
state and that you otherwise  satisfy the  suitability  standards  applicable to
purchasers of the Shares.  All potential  investors  must answer all  applicable
questions and complete,  date and sign this Questionnaire.  Please print or type
your  responses and attach  additional  sheets of paper if necessary to complete
your answers to any item.

A.       BACKGROUND INFORMATION
         ----------------------

Name:___________________________________________________________________________

Business Address:_______________________________________________________________
                               (Number and Street)
________________________________________________________________________________
(City)                         (State)                   (Zip Code)

Telephone Number: (___) ________________________________________________________

Residence Address:______________________________________________________________
                                (Number and Street)
________________________________________________________________________________
(City)                                       (State)           (Zip Code)

Telephone Number: (___) ________________________________________________________

If an individual:
Age: __________   Citizenship: ___________ Where registered to vote: ___________

If a corporation, partnership, limited liability company, trust or other entity:
Type of entity:_________________________________________________________________

                                       1
<PAGE>



State of formation:______________________   Date of formation: _________________

Social Security or Taxpayer Identification No.__________________________________

Send all correspondence to (check one):___Residence Address  ___Business Address



B.       STATUS AS ACCREDITED INVESTOR
         -----------------------------

The  undersigned  is an  "accredited  investor"  as  such  term  is  defined  in
Regulation D under the Securities  Act, as at the time of the sale of the Shares
the  undersigned  falls within one or more of the following  categories  (Please
initial one or more, as applicable): 1

____ (1)       a bank as defined in Section 3(a)(2) of the Securities Act, or a
savings and loan association or other institution as defined in Section
3(a)(5)(A) of the Securities Act whether acting in its individual or fiduciary
capacity; a broker or dealer registered pursuant to Section 15 of the Securities
Exchange Act of 1934; an insurance company as defined in Section 2(13) of the
Securities Act; an investment company registered under the Investment Company
Act of 1940 or a business development company as defined in Section 2(a)(48) of
that Act; a Small Business Investment Company licensed by the U.S. Small
Business Administration under Section 301(c) or (d) of the Small Business
Investment Act of 1958; a plan established and maintained by a state, its
political subdivisions, or any agency or instrumentality of a state or its
political subdivisions for the benefit of its employees, if such plan has total
assets in excess of $5,000,000; an employee benefit plan within the meaning of
the Employee Retirement Income Security Act of 1974, if the investment decision
is made by a plan fiduciary, as defined in Section 3(21) of such Act, which is
either a bank, savings and loan association, insurance company, or registered
investment adviser, or if the employee benefit plan has total assets in excess
of $5,000,000 or, if a self-directed plan, with the investment decisions made
solely by persons that are accredited investors;

____  (2)      a private business development company as defined in Section
202(a)(22) of the Investment Advisers Act of 1940;

____ (3)       an organization described in Section 501(c)(3) of the Internal
Revenue Code of 1986, as amended, corporation, Massachusetts or similar business
trust, or partnership, not formed for the specific purpose of acquiring the
Shares offered, with total assets in excess of $5,000,000;

____ (4)       a natural person whose individual net worth, or joint net worth
with that person's spouse, at the time of such person's purchase of the Shares
exceeds $1,000,000;

____ (5)       a natural person who had an individual income in excess of
$200,000 in each of the two most recent years or joint income with that person's
spouse in excess of $300,000 in each of those years and has a reasonable
expectation of reaching the same income level in the current year;

____________________
     1. As used in this Questionnaire, the term "net worth" means the excess of
        total liabilities.


                                       2
<PAGE>


____ (6)       a trust, with total assets in excess of $5,000,000, not formed
for the specific purpose of acquiring the Shares offered, whose purchase is
directed by a sophisticated person as described in Rule 506(b)(2)(ii) of
Regulation D; and

____ (7)       an entity in which all of the equity owners are accredited
investors (as defined above).

C.       REPRESENTATIONS
         ---------------

The  undersigned  hereby  represents  and  warrants  to the  Company as follows:
1.       Any  purchase  of the  Shares  would be solely  for the  account of the
undersigned  and not for the  account of any other  person or with a view to any
resale, fractionalization, division, or distribution thereof.

2.       The  information  contained  herein is complete and accurate and may be
relied  upon by the  Company,  and  the  undersigned  will  notify  the  Company
immediately of any material change in any of such information occurring prior to
the closing,  if any, with respect to the purchase of Shares by the  undersigned
or any co-purchaser.

3.       There  are  no  suits,  pending  litigation,   or  claims  against  the
undersigned  that could  materially  affect the net worth of the  undersigned as
reported in this Questionnaire.

4.       The  undersigned acknowledges that there may occasionally be times when
the Company, based on the advice of its counsel, determines that it must suspend
the use of the Prospectus forming a part of the Registration  Statement (as such
terms are  defined in the  Purchase  Agreement  to which this  Questionnaire  is
attached) until such time as an amendment to the Registration Statement has been
filed by the Company and  declared  effective  by the  Securities  and  Exchange
Commission or until the Company has amended or supplemented such Prospectus. The
undersigned  is aware  that,  in such  event,  the Shares will not be subject to
ready  liquidation,  and that any Shares purchased by the undersigned would have
to be held during such suspension.  The overall commitment of the undersigned to
investments  which are not readily  marketable  is not  excessive in view of the
undersigned's  net worth and  financial  circumstances,  and any purchase of the
Shares will not cause such  commitment to become  excessive.  The undersigned is
able to bear the economic risk of an investment in the Shares.

5.       In  addition to  reviewing  the Offering  Materials  (as defined in the
Purchase Agreement to which this Questionnaire is attached), the undersigned has
carefully  considered the potential risks relating to the Company and a purchase
of the Shares, and fully understands that the Shares are speculative investments
which  involve  a high  degree  of  risk of  loss  of the  undersigned's  entire
investment.  Among others, the undersigned has carefully  considered each of the
risks described in the Offering Materials.

6.       Except  as set forth below,  (a) the  undersigned  has had no position,
office or other material  relationship  currently or within the past three years
with the Company or its affiliates, (b) neither it, nor any group of which it is
a member or to which it is related,  beneficially  owns  (including the right to
acquire  or vote)  any  securities  of the  Company  and (c) it has no direct or
indirect affiliation or association with any NASD member. Exceptions:

_______________________________________________________________________________
_____________________________________________________________________________.

         (If no exceptions, write "none." If left blank, response will be deemed
to be "none.")

                                       3

<PAGE>

IN WITNESS WHEREOF,  the undersigned has executed this  Questionnaire  this ____
day of January, 2000, and declares under oath that it is truthful and correct.




                                 _____________________________________________
                                 Print Name

                                 By: _________________________________________
                                 Signature

                                 Title: ______________________________________
                                          (required for any purchaser that is
                                          a corporation, partnership, trust or
                                          other entity)



                                       4
<PAGE>


                                                                       Exhibit B
                                                                       ---------

                         CERTIFICATE OF SUBSEQUENT SALE
                         ------------------------------

[Transfer Agent]

                  RE:   Sale of Shares of Common Stock of Trimeris, Inc. (the
                        "Company") pursuant to the Company's Prospectus dated
                        __________, 2000 (the "Prospectus")

Dear Sir/Madam:

The undersigned hereby certifies, in connection with the sale of shares of
Common Stock of the Company included in the table of Selling Shareholders in the
Prospectus, that the undersigned has sold the shares pursuant to the Prospectus
and in a manner described under the caption "Plan of Distribution" in the
Prospectus and that such sale complies with all applicable securities laws,
including, without limitation, the Prospectus delivery requirements of the
Securities Act of 1933, as amended.
Selling Shareholder (the beneficial owner): ____________________________________

Record Holder (e.g., if held in name of nominee): ______________________________

Restricted Stock Certificate No.(s): ___________________________________________

Number of Shares Sold: _________________________________________________________

Date of Sale: __________________________________________________________________

In the event that you receive a stock certificate(s) representing more shares of
Common Stock than have been sold by the  undersigned,  then you should return to
the undersigned a newly issued certificate for such excess shares in the name of
the Record Holder and BEARING A RESTRICTIVE LEGEND.  Further, you should place a
stop transfer on your records with regard to such certificate.

                                                     Very truly yours,

Dated: _______________________                       By: _______________________

                                                     Print Name: _______________

                                                     Title: ____________________

cc:    Chief Financial Officer
       Trimeris, Inc.
       4727 University Drive, Suite 100
       Durham, North Carolina 27707



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