CUBIST PHARMACEUTICALS INC
10-Q/A, 1998-08-27
PHARMACEUTICAL PREPARATIONS
Previous: SOLA INTERNATIONAL INC, 8-A12B, 1998-08-27
Next: LOUIS DREYFUS NATURAL GAS CORP, SC 13D/A, 1998-08-27



<PAGE>


                       SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON D.C. 20549

                                   FORM 10-Q/A

          [X]    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d)
                     OF THE SECURITIES EXCHANGE ACT OF 1934

                  For the quarterly period ended March 31, 1997

                                       OR

          [ ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                        SECURITIES EXCHANGE ACT OF 1934

                  For the transition period from _____ to _____

                         Commission file number 0-21379

                          CUBIST PHARMACEUTICALS, INC.
             (Exact name of registrant as specified in its charter)

            Delaware                                        22-3192085
            --------                                        ----------
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
incorporation or organization)


           24 Emily Street
     Cambridge, Massachusetts                                 02139
     ------------------------                                 -----
Address of principal executive offices                      (Zip Code)

Registrant's telephone number,                            (617) 576-1999
including area code:


Indicate by check mark whether the registrant: (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months, and (2) has been subject to such filing
requirements for the past 90 days.

                                YES  X   NO 
                                    ---     ---

Indicate the number of shares outstanding of each of the issuer's classes of
common stock, as of the latest practicable date.

      Common Stock, $.001 par value                        10,580,948
      -----------------------------               ------------------------------
                Class                             Outstanding at August 25, 1998


<PAGE>


                                Explanatory Note
                                ----------------

         In response to the comments of the Commission's staff (the "Staff") 
by letter dated August 7, 1998, the Company hereby amends its Quarterly 
Report on Form 10-Q for the period ended March 31, 1997 as amended by that 
certain amendment filed with the Commission on December 12, 1997, by filing 
herewith unredacted versions of Exhibits 10.1 and 10.2. Although Confidential 
Treatment was requested for the Agreements set forth in the above-referenced 
Exhibits, such treatment was not granted because the Agreements terminated 
prior to the Staff issuing its final order. The Agreements set forth in the 
above-referenced Exhibits have terminated, and are, therefore, no longer 
material to the Company's business.


                           PART II--OTHER INFORMATION

                    ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K

        (a)  Exhibits

<TABLE>
        <S>      <C>
        10.1     Acquisition Option Agreement, dated May 5, 1997, by
                 and among Novalon Pharmaceutical Corporation, certain
                 stockholders of Novalon Pharmaceutical Corporation,
                 and the Applicant (filed herewith)
        10.2     Series B Convertible Preferred Stock Purchase
                 Agreement, dated May 5, 1997, by and between Novalon
                 Pharmaceutical Corporation and the Applicant (filed
                 herewith)
        11       Statement of Computation of Earnings Per Share
        27       Financial Data Schedule
</TABLE>


        (b)  Reports on Form 8-K


     No more reports on Form 8-K were filed by the Company during the
quarter ended March 31, 1997.


<PAGE>


                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the Registrant had duly caused this report to be signed on its behalf by the
undersigned, thereto duly authorized.

                                         CUBIST PHARMACEUTICALS, INC.


     Date:    August 26, 1998            By:      /s/      Thomas A. Shea
                                            -----------------------------
                                               Thomas A. Shea
                                               Senior Director of Finance and
                                               Administration, Treasurer
                                               (Authorized Officer and Principal
                                               Finance and Accounting Officer)

                                       2


<PAGE>


                                                                    Exhibit 10.1


                          ACQUISITION OPTION AGREEMENT


         THIS ACQUISITION OPTION AGREEMENT, dated this 5th day of May, 1997, 
is entered into by and among NOVALON PHARMACEUTICAL CORPORATION, a Delaware 
corporation (the "Corporation"), each of the persons whose signature appears 
in the signature pages of this Agreement under the caption "Novalon 
Stockholders" (collectively, the "Novalon Stockholders" and each individually 
a "Novalon Stockholder"), and CUBIST PHARMACEUTICALS, INC., a Delaware 
corporation ("Cubist").

         WHEREAS, pursuant to the terms of that certain Series B Convertible 
Preferred Stock Purchase Agreement, dated of even date herewith (the "Series 
B Stock Purchase Agreement"), between the Corporation and Cubist, the 
Corporation has agreed to issue and sell to Cubist, and Cubist has agreed to 
purchase from the Corporation, 333,333 shares of the Series B Convertible 
Preferred Stock, $.001 par value per share, of the Corporation, upon the 
terms and subject to the conditions set forth therein; and

         WHEREAS, it is a condition precedent to the consummation by Cubist 
of all of its obligations under the Series B Stock Purchase Agreement that 
the Corporation and the Novalon Stockholders enter into this Agreement.

         NOW, THEREFORE, in consideration of the mutual covenants and 
agreements herein contained, the parties hereto, intending to be legally 
bound, hereby agree as follows.

         SECTION 1. DEFINITIONS. The following terms as used herein shall 
have the meanings set forth below in this Section 1 or shall have the 
meanings ascribed thereto elsewhere as referred to below in this Section 1:

                  "Acquisition Closing" shall have the meaning ascribed to such
         term in Section 2.4 hereof.

                  "Acquisition Closing Date" shall mean the date of the 
         Acquisition Closing.

                  "Affiliate" shall mean, with regard to any Person, any other
         Person or entity that directly or indirectly controls, or is controlled
         by, or is under common control with, such Person.

                  "Agreement" and "this Agreement" shall mean this Acquisition
         Option Agreement, as amended from time to time.


<PAGE>


                  "Average Trading Price Per Share" shall mean the average of
         the closing sale prices per share of Cubist Common Stock on the Nasdaq
         Stock Market, as reported in the Wall Street Journal, for the ten
         trading days prior to the date that the Acquisition Option is exercised
         by Cubist pursuant to Section 2.1 hereof.

                  "Code" shall mean the Internal Revenue Code of 1986, as 
         amended.

                  "Collaboration" shall have the meaning ascribed to such term
         in the Series B Stock Purchase Agreement.

                  "Corresponding Novalon Stock Option" shall mean, with respect
         to any Substitute Stock Option, the Novalon Stock Option in
         substitution of which such Substitute Stock Option was granted pursuant
         to, and in accordance with, the provisions of Section 2.5 hereof.

                  "Cubist Common Stock" shall mean the common stock, $.001 par
         value per share, of Cubist.

                  "Encumbrances" shall mean any claims, liens, pledges, options,
         charges, security interests, mortgages, conditional sales agreements,
         contingent sales agreements, any title retention agreements, leases,
         encumbrances or other rights of third parties, whether voluntarily
         incurred or arising by operation of law, including, without limitation,
         any agreement to give any of the foregoing in the future.

                  "Exchange Act" shall mean the Securities Exchange Act of 1934,
         as amended.

                  "Novalon Common Stock" shall mean the common stock, $.001 par
         value per share, of the Corporation.

                  "Novalon Outstanding Stock" shall mean all shares of any and
         all classes or series of capital stock of the Corporation that are
         outstanding immediately prior to the Acquisition Closing; provided,
         however, that the term "Novalon Outstanding Stock" shall not include
         any shares of any class or series of capital stock of the Corporation
         that are owned by Cubist.

                  "Novalon Stock Option" shall have the meaning ascribed to such
         term in Section 2.5 hereof.

                  "Person" shall mean an individual, partnership, corporation,
         association, limited liability company, trust, joint venture,
         unincorporated 

                                       2

<PAGE>


         organization, and any government, governmental department or agency or 
         political subdivision thereof.

                  "Securities Act" shall mean the Securities Act of 1933, as
         amended.

                  "Subsidiaries" shall mean, collectively, all corporations,
         partnerships, limited liability companies or other Persons with respect
         to which the Corporation shall own, directly or indirectly, more that
         fifty percent (50%) of the issued and outstanding equity interests of
         such corporations, partnerships, limited liability companies or other
         Persons.

                  "Substitute Stock Option" shall have the meaning ascribed to
         such term in Section 2.5 hereof.

                  "UNC" shall mean The University of North Carolina at Chapel 
         Hill.


         SECTION 2.  ACQUISITION OPTION.

         2.1.     Option to Acquire Stock.

                  (a) Subject to and upon the terms and conditions set forth 
in this Section 2, Cubist shall have the option (but not the obligation) to 
acquire all of the Novalon Outstanding Stock (the "Acquisition Option"). The 
Acquisition Option may only be exercised by Cubist during the period 
commencing on the date hereof and ending on February 5, 1998 (the 
"Acquisition Option Period"). Cubist shall exercise the Acquisition Option by 
giving written notice of exercise to the Corporation (the "Exercise Notice"), 
which Exercise Notice shall specify the proposed structure of the transaction 
pursuant to which Cubist shall acquire all of the Novalon Outstanding Stock 
and the proposed date by which such transaction will be consummated. The 
Corporation shall send to each Novalon Stockholder a copy of the Exercise 
Notice promptly after receipt thereof by the Corporation.

                  (b) In the event that Cubist shall not have exercised the 
Acquisition Option on or prior to November 5, 1997 and that Cubist shall not 
have terminated this Agreement pursuant to Section 12(a) hereof, then Cubist 
shall be obligated to make an additional $500,001 equity investment in the 
Corporation (the "Additional Equity Investment") upon the terms and 
conditions set forth in this Section 2.1(b). Cubist shall effect the 
Additional Equity Investment by purchasing an additional 166,667 shares (the 
"Additional Series B Preferred Shares") of Series B Convertible Preferred 
Stock of the Corporation at a purchase price of $3.00 per share. Cubist's 
obligation to effect the Additional Equity Investment shall be subject to the 
conditions that (i) the Corporation shall have executed and delivered to 
Cubist a counterpart of a stock purchase agreement, in form and substance 
substantially the 

                                       3

<PAGE>


same as Series B Stock Purchase Agreement (except that such stock purchase 
agreement shall not contain any provisions pertaining to the Collaboration), 
more fully implementing the terms of the purchase and sale of the Additional 
Series B Preferred Shares and (ii) all of the parties to each of the Related 
Agreements (as defined in the Series B Stock Purchase Agreement) shall have 
entered into such amendments to such Related Agreement as may be necessary to 
ensure that the Additional Series B Preferred Shares become subject to, and 
entitled to the benefits of, such Related Agreement.

         2.2. Structure of the Transaction; Acquisition Agreement. Upon 
exercise by Cubist of the Acquisition Option pursuant to, and in accordance 
with, the provisions of Section 2.1 above, the acquisition by Cubist of all 
of the Novalon Outstanding Stock (the "Acquisition") shall be effected 
pursuant to a transaction structured as a merger, a reverse or forward 
triangular merger, an asset acquisition, a stock acquisition or otherwise, as 
may be selected and requested by Cubist and specified in the Exercise Notice 
to be delivered to the Corporation and the Novalon Stockholders pursuant to 
Section 2.1 hereof. The Corporation hereby acknowledges and agrees that the 
structure of any such transaction may require that its separate corporate 
existence terminate, such as, for example, in the case of a merger or a 
reverse triangular merger. Each Novalon Stockholder hereby acknowledges and 
agrees that, in the event that the structure of any such transaction is a 
stock acquisition, he will sell or cause to be sold to Cubist all of the 
shares of capital stock of the Corporation owned by such Novalon Stockholder 
on the Acquisition Closing Date. The Corporation and the Novalon Stockholders 
hereby acknowledge and agree that, in the event that Cubist exercises the 
Acquisition Option, the Corporation and the Novalon Stockholders will be 
required to enter into an acquisition agreement with Cubist and/or its 
Subsidiaries or Affiliates pursuant to which the Acquisition will be 
consummated, and that the terms and conditions of any such acquisition 
agreement shall include and/or be consistent with all of the terms set forth 
in this Agreement and shall include such other reasonable terms and 
provisions (including representations and warranties, covenants, 
indemnification provisions and conditions to closing) as are customary for 
similar transactions (any such acquisition agreement being hereinafter 
referred to as the "Definitive Acquisition Agreement"). Upon the execution 
and delivery of the Definitive Acquisition Agreement, this Agreement shall be 
deemed to have been terminated and superseded by the Definitive Acquisition 
Agreement. The failure of the parties to mutually agree upon and enter into 
the Definitive Acquisition Agreement shall in no way relieve the Corporation 
and the Novalon Stockholders from their respective obligations hereunder to 
consummate the Acquisition upon and subject to the terms and provisions of 
this Agreement. The failure or refusal of any party hereto to enter into the 
Definitive Acquisition Agreement having reasonable and customary terms and 
conditions shall be a material breach of such party's obligations under this 
Agreement.

                                       4

<PAGE>


         2.3.     Consideration; Escrow; Adjustments.

                  (a) The aggregate purchase price payable by Cubist for the 
Novalon Outstanding Stock shall be $10,000,000 (the "Purchase Price"), 
subject to adjustment pursuant to Section 2.3(b) hereof (the Purchase Price, 
as so adjusted, being referred to herein as the "Adjusted Purchase Price"). 
At the Acquisition Closing, Cubist shall make payment of such aggregate 
purchase price by issuing to the Novalon Stockholders, as a group, that 
number of shares of Cubist Common Stock (the "Consideration Shares") as shall 
be equal to the quotient obtained by dividing (i) the Adjusted Purchase Price 
by (ii) the Average Trading Price Per Share. Cubist shall not be required to 
issue any fractional share, but, in lieu thereof, Cubist shall make a cash 
payment equal to the product obtained by multiplying (x) such fractional 
share by (y) the Average Trading Price Per Share. The Consideration Shares 
and any cash payment made in lieu of any fractional share shall be allocated 
among the Novalon Stockholders ratably in proportion to the respective number 
of shares of Novalon Common Stock owned by the Novalon Stockholders 
immediately prior to the Acquisition Closing.

                  (b) The Purchase Price shall be reduced by the aggregate 
amount of any liabilities incurred by the Corporation after December 31, 1996 
that are outside the ordinary course of business of the Corporation.

                  (c) Notwithstanding anything in Section 2.3(a) to the 
contrary, Cubist shall be entitled to hold-back up to ten percent (10%) of 
the Consideration Shares in escrow until the third anniversary of the 
Acquisition Closing. Cubist shall be entitled to proceed against any of the 
Consideration Shares held in escrow in the event that Cubist shall have any 
claim for indemnification against the Novalon Stockholders.

                  (d) Notwithstanding anything in Section 2.3(a) to the 
contrary, Cubist shall be entitled (but not required) to pay up to twenty 
percent (20%) of the Purchase Price in cash, in which case the number of 
Consideration Shares shall be ratably adjusted based on the Average Trading 
Price Per Share.

         2.4. Closing. If, but only if, the Acquisition Option is exercised 
by Cubist pursuant to, and in accordance with, the provisions of Section 2.1 
above, the closing of the Acquisition (the "Acquisition Closing") shall be 
held at the offices of Bingham, Dana & Gould LLP, 150 Federal Street, Boston, 
Massachusetts, on such date as may be mutually agreed upon by Cubist and the 
Corporation; provided, however, that, if Cubist and the Corporation are 
unable to agree upon such date, then such date shall be designated by Cubist, 
but Cubist may not designate a date earlier than the thirtieth day following 
the date that the Exercise Notice is given. Cubist and the Corporation, or, 
in the absence of agreement as to the Acquisition Closing Date, Cubist alone, 
shall give written notice to the Novalon Stockholders of the Acquisition 
Closing Date. At the

                                       5

<PAGE>


Acquisition Closing, the parties shall take such actions as may be required 
in order to consummate the Acquisition.

         2.5. Stock Options. At the Acquisition Closing, if any, each stock 
option of the Corporation that is outstanding immediately prior thereto (each 
a "Novalon Stock Option" and collectively, the "Novalon Stock Options") shall 
be canceled, and Cubist shall grant to the holder thereof a stock option 
under Cubist's Amended and Restated 1993 Stock Option Plan (each such stock 
option granted by Cubist being referred to herein as a "Substitute Stock 
Option" and, collectively with all other stock options granted by Cubist 
pursuant to this Section 2.5, the "Substitute Stock Options") in substitution 
for such holder's canceled Novalon Stock Option; provided, however, that in 
no event shall Cubist be obligated to grant a Substitute Stock Option 
pursuant to this Section 2.5 with respect to any Novalon Stock Option that 
was not outstanding as of March 21, 1997. Each Substitute Stock Option shall 
be exercisable for the number of shares of Cubist Common Stock as shall be 
equal to the product of (A) the number of shares of Novalon Common Stock that 
would be issued upon exercise of the Corresponding Novalon Stock Option if 
such Corresponding Novalon Stock Option were exercised immediately prior to 
the Acquisition Closing, multiplied by (B) a fraction, the numerator of which 
is the Consideration Shares, and the denominator of which is the number of 
shares of Novalon Common Stock deemed outstanding immediately prior to the 
Acquisition Closing (determined in the manner set forth in Section 2.6 
below). The exercise price per share of each Substitute Stock Option shall be 
equal to the quotient obtained by dividing (A) the exercise price per share 
of the Corresponding Novalon Stock Option by (B) a fraction, the numerator of 
which is the Consideration Shares, and the denominator of which is the number 
of shares of Novalon Common Stock deemed outstanding immediately prior to the 
Acquisition Closing (determined in the manner set forth in Section 2.6 
hereof). Each Substitute Stock Option shall vest or become exercisable on the 
same basis as its Corresponding Novalon Stock Option. It is the intention of 
the parties that the Substitute Stock Options be treated as non-qualified 
stock options for income tax purposes. At the Acquisition Closing, Cubist 
shall enter into a non-qualified stock option agreement with each individual 
to whom Cubist must grant a Substitute Stock Option pursuant to this Section 
2.5, which non-qualified stock option agreement shall evidence the terms of 
the Substitute Stock Option to which it pertains and shall otherwise be 
substantially in the form of Cubist's standard form of non-qualified stock 
option agreement.

         2.6. Common Stock Deemed Outstanding. For purposes of Section 2.5 
hereof, the number of shares of Novalon Common Stock deemed outstanding 
immediately prior to the Acquisition Closing shall be equal to (i) the number 
of shares of Novalon Common Stock that are actually issued and outstanding 
immediately prior to the Acquisition Closing, plus (ii) the number of shares 
of Novalon Common Stock issuable immediately prior to the Acquisition Closing 
upon

                                       6

<PAGE>


exercise, exchange or conversion of any security or instrument exercisable or 
exchangeable for, or convertible into, shares of Novalon Common Stock 
immediately prior to the Acquisition Closing. Without limiting the generality 
of the foregoing provisions of this Section 2.6, the shares of Common Stock 
issuable immediately prior to the Acquisition Closing upon conversion of any 
Preferred Stock then issued and outstanding shall be included, for purposes 
of Section 2.5 above, among the number of shares of Novalon Common Stock 
deemed outstanding immediately prior to the Acquisition Closing.

         2.7. Accounting Treatment. The parties intend that the Acquisition 
shall be treated as a pooling of interests for accounting purposes.

         2.8. Tax Treatment. The parties intend that the Acquisition shall be 
treated as a reorganization for purposes of Section 368 of the Code.

         SECTION 3. REPRESENTATIONS AND WARRANTIES OF THE CORPORATION AND THE 
NOVALON STOCKHOLDERS. The Corporation and the Novalon Stockholders hereby 
jointly and severally represent and warrant to Cubist that the 
representations and warranties made by the Corporation in the Series B Stock 
Purchase Agreement are true and correct, all to the same extent as if such 
representations and warranties were set forth in full herein.

         SECTION 4. SPECIAL REPRESENTATIONS AND WARRANTIES OF THE NOVALON 
STOCKHOLDERS. The Novalon Stockholders hereby represent and warrant to Cubist 
as follows:

         4.1. Due Authorization, Etc.

                  (a) Each Novalon Stockholder that is not a natural person 
has obtained all necessary authorizations and approvals from its Board of 
Directors and shareholders, or Board of Trustees or other governing body, 
required for the execution and delivery of this Agreement and the 
consummation of the transactions contemplated hereby. This Agreement has been 
duly executed and delivered by each of the Novalon Stockholders and 
constitutes the legal, valid and binding obligation of each of the Novalon 
Stockholders enforceable against each of the Novalon Stockholders in 
accordance with its terms.

                  (b) The execution, delivery and performance of this 
Agreement by each Novalon Stockholder and his, her, or its participation in 
the consummation of the transactions contemplated hereby are within such 
Novalon Stockholder's full legal right, power and authority and do not 
contravene, permit the termination of or constitute a default (or an event 
which, with or without the giving of notice or the passage of time, or both, 
will constitute a default) under (i) the corporate charter and By-Laws, or 
other constituent instruments, of any Novalon Stockholder that is 

                                       7

<PAGE>


not a natural person, or (ii) any agreement or other instrument binding upon 
such Novalon Stockholder, and will not result in the creation or imposition 
of any lien, charge or encumbrance in favor of any third party upon any of 
such Novalon Stockholder's assets or properties. The execution, delivery and 
performance by the Novalon Stockholders of this Agreement do not violate any 
provision of applicable law or regulations or any judgment, injunction, 
award, decree or order to which any such Novalon Stockholder is subject.

                  (c) None of the Novalon Stockholders has any present plan 
or intention to sell or otherwise transfer the shares of Cubist Common Stock 
to be received in connection with the Acquisition.

         4.2. Title to Stock. Schedule 4.2 hereto sets forth the number of 
shares of Novalon Common Stock owned by each Novalon Stockholder on the date 
hereof. Each Novalon Stockholder owns of record and beneficially, and on the 
Acquisition Closing Date will own of record and beneficially, all right, 
title and interest in and to the shares of Novalon Common Stock set forth 
opposite such Novalon Stockholder's name on Schedule 4.2 hereto, free and 
clear of all Encumbrances.

         4.3. Ownership of Cubist Capital Stock. As of the date hereof, none 
of the Corporation, the Novalon Stockholders or their respective affiliates 
or associates (as such terms are defined under the Exchange Act), (i) 
beneficially own, directly or indirectly, or (ii) are parties to any 
agreement, arrangement or understanding for the purpose of acquiring, 
holding, voting or disposing of, in each case, shares of capital stock of 
Cubist other than as a result of this transaction.

         4.4. Securities Act Matters.

                  (a) If and to the extent that the Acquisition is 
consummated, each Novalon Stockholder will be acquiring the shares of Cubist 
Common Stock to be issued to such Stockholder pursuant to the Acquisition for 
such Stockholder's account for investment and not with a view to the 
distribution thereof. Each Novalon Stockholder acknowledges that the 
Consideration Shares to be acquired by such Novalon Stockholder in connection 
with the Acquisition will not be registered under the Securities Act and, 
therefore, such Consideration Shares must be held, and the economic risk of 
the investment must be borne, indefinitely unless and until such 
Consideration Shares are subsequently registered under the Securities Act or 
an exemption from such registration is available.

                  (b) Such Stockholder has received copies of Cubist's Annual 
Report to Stockholders for 1997 and Cubist's Annual Report on Form 10-K for 
its fiscal year ended December 31, 1996 (the "SEC Material"). Cubist has made 
available to each Novalon Stockholder or such Novalon Stockholder's purchaser 
representative, if any, the opportunity to ask questions of, and receive 
answers from, Cubist or 

                                       8

<PAGE>


persons acting on its behalf concerning the terms and conditions of the 
Acquisition and to obtain any additional information that such Novalon 
Stockholder or such Novalon Stockholder's purchaser representative may deem 
necessary to verify the accuracy of the information contained in the SEC 
Material.

                  (c) Each Novalon Stockholder is an "accredited investor" as 
defined in Rule 501 promulgated under the Securities Act or meets the 
requirements of Section 4.4(d) below.

                  (d) As indicated in Schedule 4.4 hereto, each Novalon 
Stockholder either (i) has such knowledge and experience in financial and 
business matters so that such Stockholder is capable of evaluating the merits 
and risks of an investment in Cubist, or (ii) has relied upon the advice of 
such Novalon Stockholder's purchaser representative, named in Schedule 4.4 
hereto, with regard to the considerations involved in making such investment, 
and such purchaser representative and such Novalon Stockholder together have 
such knowledge and experience in financial and business matters so that such 
purchaser representative and Novalon Stockholder are capable of evaluating 
the merits and risks of such investment.

                  (e) At the Acquisition Closing, each Novalon Stockholder 
shall enter into a Registration Rights Agreement with Cubist, in form and 
substance reasonably satisfactory to such Novalon Stockholder and Cubist, 
pursuant to which such Novalon Stockholder shall be granted customary 
"piggyback" registration rights with respect to any registration statement on 
Form S-1 or Form S-3 filed by Cubist with the Securities Exchange Commission 
in connection with any public offering of shares of Cubist Common Stock for 
Cubist's own account at any time during the period commencing on the last 
business day of the sixth month following the Acquisition Closing Date and 
ending on the first anniversary of the Acquisition Closing Date. Each Novalon 
Stockholder hereby agrees that such Registration Rights Agreement shall also 
provide that such Novalon Stockholder shall not be entitled to exercise his, 
her or its rights thereunder to the extent that any such exercise would 
disqualify the Acquisition as a "pooling of interests" for accounting 
purposes.

         SECTION 5. CONDUCT OF BUSINESS PRIOR TO ACQUISITION CLOSING DATE. 
The Corporation covenants and agrees that (and the Stockholders covenant and 
agree that they will cause the Corporation to), from and after the date of 
this Agreement and until the earlier of (i) the Acquisition Closing Date or 
(ii) the expiration date of the Acquisition Option Period, except as 
otherwise specifically consented to or approved by Cubist in writing:

         5.1. Full Access. The Corporation shall afford to Cubist and its 
authorized representatives full access during normal business hours to all 
properties, books, records, contracts and documents of the Corporation and 
its Subsidiaries and a full 

                                       9

<PAGE>


opportunity to make such investigations as Cubist or any of its authorized 
representatives shall desire to make of the Corporation and its Subsidiaries, 
and the Corporation shall furnish or cause to be furnished to Cubist and its 
authorized representatives all such information with respect to the affairs 
and businesses of Corporation and its Subsidiaries as Cubist may reasonably 
request.

         5.2. Carry on in Regular Course. The Corporation and its 
Subsidiaries shall maintain their owned and leased properties in good 
operating condition and repair, reasonable wear and tear excepted, and to 
make all necessary renewals, additions and replacements thereto. The 
Corporation and its Subsidiaries shall carry on their business diligently and 
substantially in the same manner as heretofore and not make or institute any 
unusual or novel methods of manufacture, purchase, sale, lease, management, 
accounting or operation. The Corporation and its Subsidiaries shall preserve 
all of their accounting and business records, corporate records, trade 
secrets and proprietary information for the benefit of Cubist.

         5.3. No Dividends, Issuances, Repurchases, Etc. The Corporation 
shall not declare or pay any dividends (whether in cash, shares of stock, 
property or otherwise) on, or make any other distribution (whether in cash, 
shares of stock, property or otherwise) in respect of, any shares of its 
capital stock, or authorize, sell, issue, purchase, redeem or acquire for 
value any shares of its capital stock or any options, warrants or rights to 
acquire any shares of its capital stock.

         5.4. No Increases. Neither the Corporation nor any of its 
Subsidiaries shall increase the compensation payable or to become payable to 
officers, employees or consultants, or increase any bonus, insurance, pension 
or other benefit plan, payment or arrangement made to, for or with any such 
officers, employees or consultants.

         5.5 Loans; Investments; Prepayments; Contingent Liabilities. Neither 
the Corporation nor any of its Subsidiaries shall borrow money from, or lend 
money to, any Person. Neither the Corporation nor any of its Subsidiaries 
shall make any investment in any Person. Neither the Corporation nor any of 
its Subsidiaries shall guarantee, indemnify or otherwise become contingently 
liable in any way, or act as a surety with respect to, any debt, liability or 
obligation of any Person.

         5.6 Prepayments; Forgiveness of Debt. Neither the Corporation nor 
any of its Subsidiaries shall (i) prepay any of its debt obligations or 
otherwise accelerate payment of any of its debt obligations or (ii) forgive 
any debt or obligation owed to the Corporation or such Subsidiary.

         5.7 Expenditures. Neither the Corporation nor any of its 
Subsidiaries shall accrue, expend or commit, in any single transaction or 
series of related 

                                       10

<PAGE>


transactions, any amount in excess of $50,000 without the prior written 
consent of Cubist.

         5.8 No Unauthorized Subsidiaries. Neither the Corporation nor any of 
its Subsidiaries shall not acquire, own or otherwise have or control any 
equity interest in any corporation, partnership, limited liability company or 
any other Person, without the prior written consent of Cubist.

         5.9. Contracts, Commitments and Related Matters. Neither Corporation 
nor any of its Subsidiaries shall enter into any contract or commitment or 
engage in any transaction not in the usual and ordinary course of business 
and consistent with their normal business practices.

         5.10. Sale, Exchange, Lease or License of Assets. Neither 
Corporation nor any of its Subsidiaries shall sell, exchange, license, lease 
or otherwise dispose of any asset or properties without the prior written 
consent of Cubist. Without limiting the generality of the foregoing, neither 
the Corporation nor any of its Subsidiaries shall license any of its 
intellectual property to any Person without the prior written consent of 
Cubist.

         5.11. Acquisitions of Assets. Except with the prior written consent 
of Cubist, neither the Corporation nor any of its Subsidiaries shall 
purchase, license, lease or otherwise acquire any asset or properties, except 
for acquisitions of inventory, supplies, tools, spare parts, research 
equipment and supplies, laboratory equipment and supplies and biological 
materials, in each case in the ordinary course of business consistent with 
past practices. Without limiting the generality of the foregoing, neither the 
Corporation nor any of its Subsidiaries shall license any of intellectual 
property from any Person without the prior written consent of Cubist.

         5.12. Preservation of Organization. The Corporation shall use its 
best efforts to preserve the business organization of Corporation and its 
Subsidiaries intact, to keep available to Cubist the present officers and 
employees of Corporation and its Subsidiaries and to preserve for Cubist the 
present relationships with suppliers and customers and others having business 
relations with the Corporation or any of its Subsidiaries. The Corporation 
shall not amend its Certificate of Incorporation or By-Laws, except with the 
prior written consent of Cubist. Neither the Corporation nor any of its 
Subsidiaries shall merge or consolidate with any other Person, or acquire any 
stock or securities of any other Person.

         5.13. No Default. Neither the Corporation nor any of its 
Subsidiaries shall do any act or omit to do any act, or permit any act or 
omission to act, which will cause a material breach of any contract, 
commitment or obligation of the Corporation or any of its Subsidiaries.

                                       11

<PAGE>


         5.14. Compliance with Laws. The Corporation and its Subsidiaries 
shall duly comply in all material respects with all laws, regulations and 
orders applicable with respect to their business.

         5.15. Title to Assets. The Corporation shall continue to have good 
and valid record and marketable title to all of its assets, free and clear of 
all Encumbrances.

         5.16. Advice of Change. The Corporation shall promptly advise Cubist 
in writing of any material adverse change in the business, condition, 
operations, prospects or assets of the Corporation and its Subsidiaries.

         5.17. Consents of Third Parties. The Corporation shall employ its 
best efforts to secure, before the Acquisition Closing Date, the consent, in 
form and substance satisfactory to Cubist and Cubist's counsel, to the 
consummation of the transactions contemplated by this Agreement by each party 
to any contract, commitment or obligation of the Corporation or any of its 
Subsidiaries, under which such transactions would constitute a default, would 
accelerate, modify or vest obligations of the Corporation or any of its 
Subsidiaries or would permit cancellation of any such contract.

         5.18.  Transactions  with  Affiliates.  Neither  Corporation nor any 
of its Subsidiaries will enter into any transaction with any Affiliate.

         SECTION 6.  COVENANTS OF THE PARTIES.

         6.1. "Target Space" Technology. Within ninety (90) days of the date 
of this Agreement, the Corporation shall provide Cubist with a copy of a 
patent application filed by, or assigned to, the Corporation with respect to 
certain inventions relating to the Target Space technology described in more 
detail in Schedule 6.1 hereto (the "Target Space Technology"). For a period 
of ninety (90) days after copies of such patent application are delivered to 
Cubist, Cubist shall have the right to negotiate with the Corporation to 
acquire from the Corporation all of the Corporation's right, title and 
interest in and to such patent application, the inventions disclosed therein, 
and the Target Space Technology. If Cubist and the Corporation are unable to 
agree upon the terms of such acquisition within such 90 day period, then 
Cubist shall have no rights to such patent application, the inventions 
disclosed therein or the Target Space Technology, and, prior to the 
Acquisition Closing, if any, the Corporation shall transfer all of its right, 
title and interest in and to such patent application, the inventions 
disclosed therein and the Target Space Technology so that they are not 
included among the assets of the Corporation at the time of the Acquisition 
Closing. If the Target Space Technology is not acquired by Cubist, Dana M. 
Fowlkes and those other Novalon Stockholders that will become employees of 
Cubist from and after the Acquisition Closing hereby agree that they shall 
not have any role or involvement in conducting research and development 
activities or 

                                       12

<PAGE>


commercializing the Target Space Technology (it being understood that, from 
and after the Acquisition Closing, Cubist will expect that Dr. Fowlkes and 
such other Novalon Stockholders will devote their entire time, attention and 
energies to the businesses of the Corporation and Cubist). The provisions of 
the foregoing sentence shall not preclude Dr. Fowlkes and such other Novalon 
Stockholders from owning a a direct or indirect passive equity interest in 
the Target Space Technology.

         6.2. Novalon's Director of Business Development. During the 
Acquisition Option Period, Cubist and the Corporation shall consider and 
discuss whether to extend an offer of employment to Clay Thorp, the 
Corporation's current Director of Business Development. The parties hereby 
acknowledge that the foregoing provisions of this Section 6.2 do not obligate 
Cubist to employ, or offer employment to, Clay Thorp.

         6.3. Location of Corporation's Operations. During the Acquisition 
Option Period, Cubist and the Corporation shall consider and discuss the 
advantages and disadvantages to Cubist of keeping the businesses and 
operations of the Corporation in the Chapel Hill, North Carolina area. If, 
after such discussions, Cubist determines, in its sole discretion, that it is 
in Cubist's best interests to relocate the businesses and operations of the 
Corporation to another location, Cubist shall be free to effect such 
relocation at any time after the Acquisition Closing Date upon providing 
adequate notice thereof.

         6.4. Transfer of Stock; Title to Stock. During the period commencing 
on the date hereof and ending on the earlier of (x) the expiration date of 
the Acquisition Option Period or (y) Acquisition Closing Date, each Novalon 
Stockholder hereby covenants that:

                  (i) such Novalon Stockholder shall not sell, convey, 
transfer, assign, pledge, encumber or otherwise dispose of any shares of 
capital stock of the Corporation or any interest therein; and

                  (ii) such Novalon Stockholder shall continue to have good 
and valid record and marketable title to all of the shares of capital stock 
of the Corporation owned by such Novalon Stockholder on the date hereof, and 
all of such shares shall continue to be free and clear of all Encumbrances.

         6.5. Pooling and Tax-Free Reorganization Treatment. None of the 
Corporation, the Novalon Stockholders or Cubist shall intentionally take or 
cause to be taken any action, whether before or after the Acquisition 
Closing, which would disqualify the Acquisition as a "pooling of interests" 
for accounting purposes or as a "reorganization" within the meaning of 
Section 368 of the Code.

                                       13

<PAGE>


         6.6. No Solicitation. Unless and until the expiration of the 
Acquisition Option Period, none of the Corporation, its officers, directors, 
employees, representatives and agents, including, but not limited to, 
investment bankers, attorneys and accountants, or the Novalon Stockholders 
shall (and the Novalon Stockholders will not permit the Corporation to) 
directly or indirectly encourage, solicit, initiate or participate in any 
discussions or negotiations with, or provide any information to, any 
corporation, partnership, person or other entity or group (other than Cubist 
and its affiliates or representatives) concerning any offer or proposal for 
any merger, tender offer, sale of substantial assets, sale of shares of 
capital stock or debt securities or similar transaction involving the 
Corporation (an "Acquisition Proposal"). The Corporation will immediately 
communicate to Cubist the terms of any proposal, discussion, negotiation or 
inquiry relating to an Acquisition Proposal and the identity of the party 
making such proposal or inquiry which it may receive in respect of any such 
transaction.

         6.7. Public Announcements. Neither the Corporation nor Cubist will 
distribute any news release or other public information disclosure with 
respect to this Agreement or any of the transactions contemplated hereby 
without the prior consent of the other; provided, however, any such prior 
consent shall not be required with respect to the distribution of any such 
news release or other public information disclosure to the extent such 
distribution is required to satisfy either the Corporation's or Cubist's 
obligations under applicable securities laws or is otherwise required by law.

         6.8. Standstill. If the Acquisition Closing occurs, each Novalon 
Stockholder hereby covenants and agrees that, so long as such Novalon 
Stockholder or any of its affiliates (as such term is defined in the Exchange 
Act) owns of record or beneficially (as such term is defined in the Exchange 
Act) any of the Consideration Shares, neither such Novalon Stockholder nor 
its affiliates shall, directly or indirectly, unless authorized in writing by 
Cubist, in any manner:

                  (i) acquire, offer or propose to acquire, solicit an offer 
to sell or agree to acquire, directly or indirectly, alone or in concert with 
others, by purchase or otherwise, any direct or indirect beneficial interest 
in any voting securities or direct or indirect rights, warrants or options to 
acquire, or securities convertible into or exchangeable for, any voting 
securities of Cubist;

                  (ii) make, or in any way participate in, directly or 
indirectly, alone or in concert with others, any "solicitation" of "proxies" 
to vote (as such terms are used in the proxy rules of the Securities and 
Exchange Commission promulgated pursuant to Section 14 of the Exchange Act) 
or seek to advise or influence in any manner whatsoever any person or entity 
with respect to the voting of any voting securities of Cubist;

                                       14

<PAGE>


                  (iii) form, join or in any way participate in a "group" 
within the meaning of Section 13(d)(3) of the Exchange Act with respect to 
any voting securities of Cubist;

                  (iv) acquire, offer to acquire or agree to acquire, 
directly or indirectly, alone or in concert with others, by purchase, 
exchange or otherwise, (A) any of the assets, tangible or intangible, of 
Cubist or any of its affiliates or (B) direct or indirect rights, warrants or 
options to acquire any assets of Cubist or any of its affiliates, except for 
such assets as are then being offered for sale by Cubist, or any of its 
affiliates;

                  (v) arrange, or in any way participate, directly or 
indirectly, in any financing for the purchase of any voting securities or 
securities convertible or exchangeable into or exercisable for any voting 
securities or assets of Cubist or any of its affiliates;

                  (vi) otherwise act, alone or in concert with others, to 
seek to propose to Cubist or any of its stockholders any merger, business 
combination, restructuring, recapitalization or other transaction to or with 
Cubist or otherwise see, alone or in concert with others, to control, change 
or influence the management, board of directors, or policies of Cubist or 
nominate any person as a director who is not nominated by the then incumbent 
directors, or propose any matter to be voted upon by the stockholders of 
Cubist; or

         (vii) take any action that might result in Cubist having to make a 
public announcement regarding any of the matters referred to in clauses (i) 
through (vi) of this Section 6.8, or announce an intention to do, or enter 
into any agreement or understanding or discussions with others to do, any of 
the actions restricted or prohibited under such clauses (i) through (vi).

         6.9. Non-Competition. If the Acquisition Closing occurs, each 
Novalon Stockholder hereby covenants and agrees that, during the period 
commencing on the Acquisition Closing Date and ending on the fifth 
anniversary of the Acquisition Closing Date, such Novalon Stockholder shall 
not, directly or indirectly:

                  (i) for its own account or as an employee, officer, 
director, partner, joint venturer, shareholder, investor, consultant or 
otherwise (except as an investor in a corporation whose stock is publicly 
traded and in which such Novalon Stockholder holds less than 2% of the 
outstanding voting shares), engage in any business relating to the research, 
discovery, development, sale, licensing, marketing or other commercialization 
of (i) any of the biological targets which Cubist is researching, developing, 
otherwise actively pursuing, selling, marketing or otherwise commercializing 
at the time of the Acquisition Closing (the "Cubist 

                                       15

<PAGE>


Biological Targets") or (ii) anti-bacterial and/or anti-fungal drugs whose 
principal mechanism of action is the inhibition of any Cubist Biological 
Target;

                  (ii) solicit the employment of any employee of Cubist, the 
Corporation or any of their respective Subsidiaries; or

                  (iii) interfere with any business relationship between 
Cubist, the Corporation or any other of their respective Subsidiaries, on the 
one hand, with any Person (including, without limitation, any licensor, 
licensee, collaborator, corporate partner, supplier or customer), on the 
other hand.

At the Acquisition Closing, Cubist shall deliver to the Corporation and Dana 
M. Fowlkes a list of the Cubist Biological Targets and Dr. Fowlkes shall, 
promptly thereafter, send a copy of such list to each of the other Novalon 
Stockholders.

         SECTION 7. CONDITIONS PRECEDENT TO CUBIST'S OBLIGATIONS. 
Notwithstanding Cubist's exercise of the Acquisition Option pursuant to, and 
in accordance with, the provisions of Section 2.1 hereof, Cubist shall be 
obligated to consummate the Acquisition only if each of the following 
conditions is satisfied at or prior to the Acquisition Closing Date, unless 
any such condition is waived in writing by Cubist:

         7.1. Accuracy of Representations and Warranties by the Corporation 
and the Novalon Stockholders. The representations and warranties of the 
Corporation and the Novalon Stockholders set forth in Sections 3 and 4 hereof 
shall be true and correct in all material respects as of the Acquisition 
Closing Date with the same force and effect as though made again at and as of 
the Acquisition Closing Date, except for changes permitted or required by 
this Agreement.

         7.2. Compliance by the Corporation and the Novalon Stockholders. The 
Corporation and the Novalon Stockholders shall have performed and complied in 
all material respects with all covenants and agreements contained in this 
Agreement required to be performed or complied with by them on or before the 
Acquisition Closing Date.

         7.3. No Material Change. Since December 31, 1996 there shall not 
have been or threatened to be any material damage to or loss or destruction 
of any properties or assets owned or leased by the Corporation or any of its 
Subsidiaries (whether or not covered by insurance) or any material adverse 
change in the condition (financial or otherwise), operations, business or 
assets of the Corporation and its Subsidiaries taken as a whole or imposition 
of any laws, rules or regulations which would materially adversely affect the 
condition (financial or otherwise), operations, business or assets of the 
Corporation and its Subsidiaries taken as a whole.

                                       16

<PAGE>


         7.4. Officers' Closing Certificate. The Corporation shall have 
executed and delivered to Cubist at and as of the Acquisition Closing a 
certificate, duly executed by the Corporation's President, in form and 
substance satisfactory to Cubist and Cubist's counsel, certifying that the 
conditions specified in each of Section 7.1, 7.2 and 7.3 have been satisfied.

         7.5.  Definitive  Acquisition  Agreement.  Each of Cubist,  the 
Corporation and the Novalon Stockholders shall have executed and delivered to 
each other counterparts of the Definitive Acquisition Agreement.

         7.6. UNC License Agreement. Each of the Corporation and UNC shall 
have executed and delivered to the other counterparts of a license agreement 
with respect to the U.S. patent application entitled "Electrochemical Probes 
for Detection of Molecular Interactions and Drug Discovery" and any 
continuations and divisions derived therefrom, and such license agreement 
shall be in form and substance satisfactory to Cubist and shall be in full 
force and effect prior to and immediately after the Acquisition Closing.

         7.7. Invention Assignments. The Corporation shall have made 
available to Cubist such invention assignments requested by Cubist with 
respect to the U.S. patent application entitled "Identification of Drugs 
Using Complementary Combinatorial Libraries", and such invention assignments 
shall be in form and substance satisfactory to Cubist.

         7.8. Employment and Non-Competition Agreement with Dana Fowlkes. 
Dana Fowlkes and the Corporation shall have terminated Dr. Fowlkes employment 
agreement with the Corporation, and Dr. Fowlkes shall have executed and 
delivered to Cubist an employment and non-competition agreement (the "Fowlkes 
Employment Agreement"), pursuant to which Dr. Fowlkes shall become a Vice 
President of Cubist from and after the Acquisition Closing upon such terms 
and conditions (including, without limitation, base salary and fringe 
benefits) as Cubist and Dr. Fowlkes shall have mutually agreed upon as 
reflected in the Fowlkes Employment Agreement; provided, however, that in no 
event shall the base salary and fringe benefits of Dr. Fowlkes under the 
Fowlkes Employment Agreement be less than the base salary and fringe benefits 
of Dr. Fowlkes under his employment agreement with the Corporation, as in 
effect on March 21, 1997.

         7.9. Employment Matters.

         (a) Each of the scientific employees of the Corporation shall have 
agreed to become employees of Cubist upon the same terms of employment as 
were in effect for such scientific employees on March 21, 1997; provided, 
however, that the terms 

                                       17

<PAGE>


of such scientific employees' employment with Cubist may require that such 
scientific employees relocate.

         (b) Each of the scientific employees of the Corporation shall have 
executed and delivered to Cubist a counterpart of Cubist's standard form of 
Proprietary Information and Inventions Agreement, a copy of which is attached 
to this Agreement as Exhibit A hereto.

         7.10. Consulting Agreements.

         (a) The Corporation and each of its consultants shall have 
terminated such consultant's consulting relationship with the Corporation, 
and such consultant shall have entered into a consulting agreement with 
Cubist for a term equal to the balance of the term of such consultant's 
consulting agreement with the Corporation and upon such other terms 
(including, without limitation, consulting effort and consideration) as were 
included in such consultant's consulting agreement with the Corporation, as 
in effect on March 21, 1997.

         (b) Each of the consultants of the Corporation shall have executed 
and delivered to Cubist a counterpart of Cubist's standard form of 
Proprietary Information and Inventions Agreement, a copy of which is attached 
to this Agreement as Exhibit A hereto.

         7.11. Scientific  Advisory Board.  Each of Thomas Shenk,  Holden Thorp
and Brian Kay shall have agreed to become members of Cubist's Scientific
Advisory Board.

         7.12. No Injunctions or Restraints. No temporary restraining order, 
preliminary or permanent injunction or other order issued by any court of 
competent jurisdiction or other legal restraint or prohibition preventing the 
consummation of the Acquisition shall be in effect.

         7.13. Opinion of the Corporation's Counsel. The Corporation shall 
have delivered to Cubist the opinion of Jenner & Block, counsel to the 
Corporation and the Novalon Stockholders, dated the Acquisition Closing Date 
and in form and substance reasonably satisfactory to Cubist and Cubist's 
counsel.

         7.14. Accounting Treatment. Cubist shall have received letters from 
Coopers & Lybrand L.L.P. (on behalf of Cubist) and Ernst & Young L.L.P. (on 
behalf of the Corporation and the Novalon Stockholders), dated the date of 
the Acquisition Closing, substantially to the effect that, on the basis of a 
review of this Agreement and the transactions contemplated hereby, in such 
accountants' opinion Accounting 

                                       18

<PAGE>


Principles Board Opinion No. 16 requires that the Acquisition be accounted for
as a pooling of interests.

         7.15. Tax Opinion. Cubist shall have received a legal opinion from 
Bingham, Dana & Gould LLP, counsel to Cubist, to the effect that, on the 
basis of the facts and representations set forth therein, or set forth in 
writing elsewhere and referred to therein, for federal income tax purposes 
the Acquisition constitutes a reorganization under Section 368 of the Code. 
In rendering any such opinions, such counsel may rely, to the extent it deems 
necessary or appropriate, upon opinions of other counsel and upon 
representations of an officer or officers of Cubist and the Corporation or 
any of their affiliates.

         7.16. Due Diligence. Cubist shall have completed its due diligence 
review of the Corporation and its assets, properties, contractual 
obligations, intellectual property position, business and operations, and the 
results of such due diligence review shall be satisfactory to Cubist in its 
reasonable discretion.

         7.17. Proceedings and Documents Satisfactory. All proceedings in 
connection with the Acquisition and the other transactions contemplated by 
this Agreement and all certificates and documents delivered to Cubist 
pursuant to this Section 7 shall be reasonably satisfactory to Cubist and its 
counsel.

         SECTION 8. CONDITIONS PRECEDENT TO THE CORPORATION'S AND THE NOVALON 
STOCKHOLDERS' OBLIGATIONS. Notwithstanding Cubist's exercise of the 
Acquisition Option pursuant to, and in accordance with, the provisions of 
Section 2.1 hereof, the Corporation and the Novalon Stockholders shall be 
obligated to consummate the Acquisition only if each of the following 
conditions is satisfied at or prior to the Acquisition Closing Date, unless 
any such condition is waived in writing by the Corporation:

         8.1. Compliance by Cubist. Cubist shall have performed and complied 
in all material respects with all of the covenants and agreements required to 
be performed or complied with by it on or before the Acquisition Closing Date.

         8.2. Officers' Certificate. Cubist shall have delivered to the 
Corporation a certificate of its President, dated the Acquisition Closing 
Date, stating that the conditions set forth in Section 8.1 have been 
satisfied.

         8.3. Employment and Non-Competition Agreement with Dana Fowlkes. 
Cubist shall have executed and delivered to Dana Fowlkes a counterpart of the 
Fowlkes Employment Agreement, pursuant to which Dr. Fowlkes shall become a 
Vice President of Cubist from and after the Acquisition Closing upon such 
terms and conditions (including, without limitation, base salary and fringe 
benefits) as Cubist and Dr. Fowlkes shall have mutually agreed upon as 
reflected in the

                                       19

<PAGE>


Fowlkes Employment Agreement; provided, however, that in no event shall the 
base salary and fringe benefits of Dr. Fowlkes under the Fowlkes Employment 
Agreement be less than the base salary and fringe benefits of Dr. Fowlkes 
under his employment agreement with the Corporation, as in effect on March 
21, 1997.

         8.4. Employment Matters. Cubist shall have offered employment to 
each of the scientific employees of the Corporation upon the same terms of 
employment as were applicable to such scientific employees during their 
employment by the Corporation; provided, however, that the terms of such 
scientific employees employment with Cubist may require that such scientific 
employees relocate.

         8.5. Consulting Agreements. Cubist shall have executed and delivered 
to each of the Corporation's consultants a consulting agreement with a term 
equal to the balance of the term of such consultant's consulting agreement 
with the Corporation and upon such other terms (including, without 
limitation, consulting effort and consideration) as were included in such 
consultant's consulting agreement with the Corporation, as in effect on March 
21, 1997.

         8.7. Scientific  Advisory  Board.  Each of Thomas  Shenk,  Holden  
Thorp and Brian Kay shall have been appointed as members of Cubist's 
Scientific Advisory Board.

         8.8. No Injunctions or Restraints. No temporary restraining order, 
preliminary or permanent injunction or other order issued by any court of 
competent jurisdiction or other legal restraint or prohibition preventing the 
consummation of the Acquisition shall be in effect.

         8.9. Opinion of Cubist's Counsel. Cubist shall have delivered to the 
Novalon Stockholders the opinion of Bingham, Dana & Gould LLP, counsel to 
Cubist, dated the Acquisition Closing Date and in form and substance 
reasonably satisfactory to the Novalon Stockholder and their counsel.

         8.10. Tax Opinion. The Novalon Stockholders shall have received a 
legal opinion from Jenner & Block, counsel to the Novalon Stockholders, to 
the effect that, on the basis of the facts and representations set forth 
therein, or set forth in writing elsewhere and referred to therein, for 
federal income tax purposes the Acquisition constitutes a reorganization 
under Section 368 of the Code. In rendering any such opinions, such counsel 
may rely, to the extent it deems necessary or appropriate, upon opinions of 
other counsel and upon representations of an officer or officers of Cubist 
and the Corporation or any of their affiliates.

         8.11. Proceedings and Documents Satisfactory. All proceedings in 
connection with the Acquisition and the other transactions contemplated by 
this Agreement and all certificates and documents delivered to the 
Corporation and the 

                                       20

<PAGE>


Novalon Stockholders pursuant to this Section 8 shall be reasonably 
satisfactory to the Corporation, the Novalon Stockholders and their counsel.

         SECTION 9. CONFIDENTIAL INFORMATION. Any and all non-public 
information disclosed by Cubist to Corporation or by Corporation to Cubist as 
a result of the negotiations leading to the execution of this Agreement, or 
in furtherance hereof, shall remain subject to the terms of the Confidential 
Non-Disclosure Agreement dated March 12, 1997 executed and delivered to each 
other by Cubist and the Corporation (the "Confidentiality Agreement").

         SECTION 10. SURVIVAL OF REPRESENTATIONS. Each of the representations 
and warranties in this Agreement made by the Corporation or any of the 
Novalon Stockholders shall survive the Acquisition Closing and shall expire 
on the third anniversary of the Acquisition Closing Date.

         SECTION 11. TAX CONSEQUENCES TO THE PARTIES. Cubist, on the one 
hand, and the Corporation and the Novalon Stockholders, on the other, 
understand and agree that neither Cubist, on the one hand, nor the 
Corporation or the Novalon Stockholders, on the other, are making any 
representation or warranty as to the tax consequences of this Agreement and 
the events and actions contemplated hereby. Nonetheless, if the Acquisition 
Closing occurs all parties hereto agree to report the Acquisition on their 
respective federal income tax returns as a tax-free reorganization under 
ss.368 of the Code.

         SECTION 12. TERMINATION; LIABILITIES CONSEQUENT THEREON. This 
Agreement may be terminated and the Acquisition abandoned at any time prior 
to the Acquisition Closing only as follows:

                  (a) by Cubist,  upon  notice to the  Corporation  at 
any time prior to the exercise of the Acquisition Option; or

                  (b) by Cubist or the Corporation, upon notice to the other 
at any time after the expiration of the Acquisition Option Period if Cubist 
did not timely exercise the Acquisition Option pursuant to, and in accordance 
with, the provisions of Section 2.1 hereof; or

                  (c) by Cubist, upon notice to the Corporation if the 
conditions set forth in Section 7 shall not have been satisfied within ninety 
(90) days following Cubist's exercise of the Acquisition Option pursuant to, 
and in accordance with, the provisions of Section 2.1 hereof; or

                  (d) by the Corporation, upon notice to Cubist if the 
conditions set forth in Section 8 shall not have been satisfied within ninety 
(90) days following 

                                       21

<PAGE>


Cubist's exercise of the Acquisition Option pursuant to, and in accordance 
with, the provisions of Section 2.1 hereof; or

                  (e) at any time by mutual agreement of Cubist and the 
Corporation; or

                  (f) by Cubist, if there has been any material breach of any 
representation, warranty or covenant of the Corporation or the Novalon 
Stockholders contained herein and the same has not been cured within 30 days 
after notice thereof; or

                  (g) by the Corporation, if there has been any material 
breach of any covenant of Cubist contained herein and the same has not been 
cured within 30 days after notice thereof.

Any termination pursuant to this Section 12 shall be without liability on the 
part of any party, unless such termination is the result of a material breach 
of this Agreement by a party to this Agreement in which case such breaching 
party shall remain liable for such breach notwithstanding any termination of 
this Agreement. The Confidentiality Agreement shall survive any termination 
of this Agreement.

         SECTION 13.  GENERAL.

         13.1 Expenses. Each party hereto will pay its own expenses in 
connection with the transactions contemplated hereby, whether or not such 
transactions shall be consummated; provided, however, that, on the earlier of 
(x) the Acquisition Closing or (y) the termination of this Agreement pursuant 
to Section 12 hereof, Cubist shall reimburse the Corporation, up to a maximum 
aggregate amount of $40,000, for any amounts paid or payable by the 
Corporation in respect of the reasonable fees, expenses and disbursements of 
the Corporation's outside legal, accounting and tax advisors but only if and 
to the extent that (i) such reasonable fees, expenses and disbursements 
pertain to the transactions contemplated by this Agreement, (ii) such 
reasonable fees, expenses and disbursements relate to services rendered from 
and after the date that Cubist exercises the Acquisition Option and (iii) the 
Corporation provides the Investor with a copy of the invoices submitted to 
the Corporation by such advisors and such invoices are sufficiently detailed 
to adequately support the amount of such fees, expenses and disbursements.

         13.2. Assignment and Benefits of Agreement. This Agreement shall be 
binding upon and shall inure to the benefit of the parties and their 
respective successors, but may not be assigned by any of the parties without 
the written consent of the others. Except as aforesaid or as specifically 
provided for elsewhere in this Agreement, nothing in this Agreement, express 
or implied, is intended to 

                                       22

<PAGE>


confer upon any person other than the parties hereto and their said 
successors and permitted assigns, any rights under or by reason of this 
Agreement.

         13.3 Remedies. In case that any one or more of the covenants and/or 
agreements set forth in this Agreement shall have been breached by any party 
hereto, the party or parties entitled to the benefit of such covenants or 
agreements may proceed to protect and enforce its or their rights, either by 
suit in equity and/or action at law, including, but not limited to, an action 
for damages as a result of any such breach and/or an action for specific 
performance of any such covenant or agreement contained in this Agreement. 
The rights, powers and remedies of the parties to this Agreement are 
cumulative and not exclusive of any other right, power or remedy which such 
parties may have under any other agreement or law. No single or partial 
assertion or exercise of any right, power or remedy of a party hereunder 
shall preclude any other or further assertion or exercise thereof.

         13.4 Entire Agreement. Except as specifically otherwise provided for 
elsewhere in this Agreement, this Agreement contains the entire agreement 
among the parties with respect to the subject matter hereof and supersedes 
all prior and contemporaneous arrangements or understandings with respect 
thereto.

         13.5 Notices. All notices, requests, consents and other 
communications hereunder to any party shall be deemed to be sufficient if 
contained in a written instrument delivered in person or duly sent by first 
class, registered, certified or overnight mail, postage prepaid, or 
telecopied with a confirmation copy by regular mail, addressed or telecopied, 
as the case may be, to such party at the address or telecopier number, as the 
case may be, set forth below or such other address or telecopier number, as 
the case may be, as may hereafter be designated in writing by the addressee 
to the addressor listing all parties:

          (i)  If to the 
               Corporation, to:

                                      Novalon Pharmaceutical Corporation
                                      214 West Cameron Avenue, Suite B
                                      Chapel Hill, N.C. 27516
                                      Attention:  Dana M. Fowlkes, M.D., Ph.D.,
                                                        President & CEO
                                      Telecopier:(919) 968-9255

                                      with a copy to:

                                      Jenner & Block
                                      12th Floor
                                      601 Thirteenth Street, N.W.
                                      Washington, D.C.  20005

                                       23

<PAGE>


                                      Attention:  D. Joe Smith, Esq.
                                      Telecopier:  (203) 639-6066

          (ii) If to Cubist, to:

                                      Cubist Pharmaceuticals, Inc.
                                      24 Emily Street
                                      Cambridge, MA  02139
                                      Attention:  Scott M. Rocklage, Ph.D.
                                      Telecopier:  (617) 576-0232

                                      with a copy to:

                                      Bingham, Dana & Gould LLP
                                      150 Federal Street
                                      Boston, MA 02110-1726
                                      Attention: Julio E. Vega, Esquire
                                      Telecopier:(617) 951-8736

         (iii)  If to any Novalon 
                Stockholder, to

                                      c/o Novalon Pharmaceutical Corporation
                                      214 West Cameron Avenue, Suite B
                                      Chapel Hill, N.C. 27516
                                      Attention:  Dana M. Fowlkes, M.D., Ph.D.,
                                                        President & CEO
                                      Telecopier:(919) 968-9255

                                      with a copy to:

                                      Jenner & Block
                                      12th Floor
                                      601 Thirteenth Street, N.W.
                                      Washington, D.C.  20005
                                      Attention:  D. Joe Smith, Esq.
                                      Telecopier:  (203) 639-6066


Any notice or other communication pursuant to this Agreement shall be deemed 
to have been duly given or made and to have become effective (i) when 
delivered in hand to the party to which it was directed, (ii) if sent by 
telex, telecopier, facsimile machine or telegraph and properly addressed in 
accordance with the foregoing provisions of this Section 13.5, when received 
by the addressee, (iii) if sent by commercial courier guaranteeing next 
business day delivery, on the business day 

                                       24

<PAGE>


following the date of delivery to such courier, or (iii) if sent by 
first-class mail, postage prepaid, and properly addressed in accordance with 
the foregoing provisions of this Section 13.5, (A) when received by the 
addressee, or (B) on the third business day following the day of dispatch 
thereof, whichever of (A) or (B) shall be the earlier.

         13.6 Amendments and Waivers. Any provision of this Agreement may be 
amended, modified or terminated, and the observance of any provision of this 
Agreement may be waived (either generally or in a particular instance and 
either retrospectively or prospectively), with, but only with, the written 
consent of each of the parties hereto.

         13.7 Severability. Any provision of this Agreement that is 
prohibited or unenforceable in any jurisdiction shall, as to such 
jurisdiction, be ineffective to the extent of such prohibition or 
unenforceability without invalidating the remaining provisions hereof, and 
any such prohibition or unenforceability in any jurisdiction shall not 
invalidate or render unenforceable such provision in any other jurisdiction.

         13.8 No Waiver of Future Breach. No failure or delay on the part of 
any party to this Agreement in exercising any right, power or remedy 
hereunder shall operate as a waiver thereof. No assent, express or implied, 
by any party hereto to any breach in or default of any agreement or condition 
herein contained on the part of any other party hereto shall constitute a 
waiver of or assent to any succeeding breach in or default of the same or any 
other agreement or condition hereof by such other party.

         13.9 Attorneys' Fees. If any party to this Agreement brings an 
action to enforce its rights under this Agreement and such party is the 
prevailing party, then such party shall be entitled to recover its costs and 
expenses, including, without limitation, reasonable attorneys' fees, incurred 
in connection with such action, including any appeal of such action. The 
amount of such costs and expenses to which such party shall be entitled shall 
be determined and set by the judge and not a jury.

         13.10 Headings. The headings of the various sections of this 
Agreement have been inserted for convenience of reference only and shall not 
be deemed to be a part of this Agreement.

         13.11 Nouns and Pronouns. Whenever the context may require, any 
pronouns used herein shall include the corresponding masculine, feminine or 
neuter forms, and the singular form of names and pronouns shall include the 
plural and vice-versa.

                                       25

<PAGE>


         13.12 Governing Law. This Agreement shall be governed by and 
construed in accordance with the laws of the State of Delaware, excluding 
choice of law rules thereof.

         13.13 Counterparts. This Agreement may be executed in any number of 
counterparts, and each such counterpart shall be deemed to be an original 
instrument, but all such counterparts together shall constitute but one 
agreement.







                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       26

<PAGE>


         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the date first above written.

                                       CORPORATION:

                                       NOVALON PHARMACEUTICAL
                                       CORPORATION


                                       By: [signature appears here]
                                          ----------------------------
                                          Name:  Dana M. Fowlkes, M.D., Ph.D.
                                          Title: President & CEO


                                       CUBIST:

                                       CUBIST PHARMACEUTICALS, INC.


                                         By: [signature appears here]
                                            ------------------------
                                            Scott M. Rocklage, President


                                       NOVALON STOCKHOLDERS:


                                         [signature appears here]
                                       --------------------------
                                       Dana M. Fowlkes

                                         [signature appears here]
                                       --------------------------
                                       Susan T. Lord
 
                                         [signature appears here]
                                       --------------------------
                                       Thomas E. Shenk

                                       27


<PAGE>


                                                                    Exhibit 10.2


             SERIES B CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT


         THIS SERIES B CONVERTIBLE PREFERRED STOCK PURCHASE AGREEMENT, dated 
this 5th day of May, 1997, is entered into by and between NOVALON 
PHARMACEUTICAL CORPORATION, a Delaware corporation (the "Corporation"), and 
CUBIST PHARMACEUTICALS, INC. (the "Investor").

         WHEREAS, the Corporation desires to issue and sell to the Investor, 
and the Investor desires to purchase from the Corporation, shares of the 
Series B Convertible Preferred Stock, $.001 par value per share, of the 
Corporation, upon the terms and subject to the conditions set forth herein.

         NOW, THEREFORE, in consideration of the mutual covenants and 
agreements herein contained, the parties hereto, intending to be legally 
bound, hereby agree as follows.

         SECTION 1. DEFINITIONS. The following terms as used herein shall 
have the meanings set forth below in this Section 1 or shall have the 
meanings ascribed thereto elsewhere in this Agreement as referred to below in 
this Section 1:

                  "Acquisition" shall have the meaning ascribed to such term in
         the Acquisition Option Agreement.

                  "Acquisition Option Agreement" shall mean that certain
         Acquisition Option Agreement, in substantially the form of Exhibit A
         hereto, among the Corporation, the Novalon Stockholders (as defined
         therein) and the Investor.

                  "Acquisition Option" shall have the meaning ascribed to such
         term in the Acquisition Option Agreement.

                  "Acquisition Option Period" shall have the meaning ascribed to
         such term in the Acquisition Option Agreement.

                  "Affiliate" shall mean, with regard to any Person, any other
         Person or entity that directly or indirectly controls, or is controlled
         by, or is under common control with, such Person.

                  "Agreement" and "this Agreement" shall mean this Series B
         Convertible Preferred Stock Purchase Agreement, dated May 5, 1997, by
         and among the Corporation and the Investor, as amended from time to
         time.


<PAGE>


                  "Benefit Plan" shall mean any plan, fund, program, policy,
         arrangement or contract, whether formal or informal, which is in the
         nature of (i) an employee pension benefit plan (as defined in Section
         3(2) of ERISA) or (ii) an employee welfare benefit plan (as defined in
         Section 3(l) of ERISA).

                  "Closing" shall have the meaning provided therefor in Section 
         3 hereof.

                  "Closing Date" shall have the meaning provided therefor in
         Section 3 hereof.

                  "Code" shall mean the Internal Revenue Code of 1986, as
         amended.

                  "Common Stock" shall mean the Common Stock, $.001 par value
         per share, of the Corporation.

                  "Environmental Laws" shall mean any Federal, state or local
         law or ordinance or regulation pertaining to the protection of human
         health, safety or the environment, including, without limitation, the
         Occupational Safety and Health Act, 29 U.S.C. Sections 651 et seq., the
         Comprehensive Environmental Response, Compensation and Liability Act,
         42 U.S.C. Sections 9601, et seq., the Emergency Planning and Community
         Right-to-Know Act, 42 U.S.C. Sections 11001, et seq., and the Resource
         Conservation and Recovery Act, 42 U.S.C. Sections 6901, et seq.

                  "ERISA" shall mean the Employee Retirement Income Security Act
         of 1974, as amended.

                  "Hazardous Substances" shall include medical waste, biological
         waste, oil and petroleum products, asbestos, polychlorinated biphenyls,
         urea formaldehyde and any other materials classified as pollutants or
         contaminants or as hazardous or toxic or as a biohazard under any
         Environmental Laws.

                  "Investors' Rights Agreement" shall mean that certain
         Investors' Rights Agreement, in substantially the form of Exhibit B
         hereto, among the Corporation and the Investors (as defined therein).

                  "Management Stock Restriction Agreement" shall mean that
         certain Stock Restriction Agreement, in substantially the form of
         Exhibit C hereto, among the Corporation, the Management 

                                       2

<PAGE>


         Stockholders (as defined therein), the Management Stockholder
         Transferees (as defined therein) and the Investors (as defined
         therein).

                  "Person" shall mean an individual, partnership, corporation,
         association, limited liability company, trust, joint venture,
         unincorporated organization, and any government, governmental
         department or agency or political subdivision thereof.

                  "Registration Rights Agreement" shall mean that certain
         Registration Rights Agreement, in substantially the form of Exhibit D
         hereto, among the Corporation and the Investors (as defined therein).

                  "Related Documents" shall mean, collectively, this Agreement,
         the Investors' Rights Agreement, the Management Stock Restriction
         Agreement, the Registration Rights Agreement, the Restated Certificate
         of Incorporation and the Acquisition Option Agreement.

                  "Restated Certificate of Incorporation" shall mean the
         Restated Certificate of Incorporation filed with the Secretary of State
         of Delaware on May 2, 1997, a copy of which is attached hereto as of
         Exhibit E, as amended and in effect from time to time.

                  "Returns" shall mean, collectively, all returns, declarations,
         reports, statements and other documents required to be filed in respect
         of Taxes.

                  "Securities Act"  shall mean the Securities Act of 1933, as 
         amended.

                  "Series A Preferred Stock" shall mean the Series A Convertible
         Preferred Stock, $.001 par value per share, of the Corporation.

                  "Series B Preferred Stock" shall mean the Series B Convertible
         Preferred Stock, $.001 par value per share, of the Corporation.

                  "Subsidiaries" shall mean, collectively, all corporations,
         partnerships, limited liability companies or other Persons with respect
         to which the Corporation shall own, directly or indirectly, more that
         fifty percent (50%) of the issued and outstanding equity interests of
         such corporations, partnerships, limited liability companies or other
         Persons.

                                       3

<PAGE>


                  "Taxes" shall mean all federal, state, local, foreign and
         other net income, gross income, gross receipts, sales, use, ad valorem,
         transfer, franchise, profits, license, lease, service, service use,
         withholding, payroll, employment, excise, severance, stamp, occupation,
         premium, property, windfall profits, customs duties, or other taxes,
         fees, assessments or other charges of any kind whatever, together with
         any interest and any penalties, additions to tax or additional amounts
         with respect thereto.

         SECTION 2.  THE SERIES B CONVERTIBLE PREFERRED STOCK.

         2.1. Series B Convertible Preferred Stock. Prior to the Closing 
Date, the Corporation will have duly authorized the issuance and sale to the 
Investor, at the Closing, of an aggregate of 333,333 shares (the "Series B 
Shares") of the Series B Preferred Stock, at a purchase price per share of 
$3.00. The Series B Shares shall have the powers, preferences, rights and 
other terms and conditions applicable to shares of Series B Preferred Stock, 
as set forth in Article IV of the Restated Certificate of Incorporation.

         2.2. Conversion Shares. Prior to the Closing Date, the Corporation 
will have duly authorized and reserved, and covenants to continue to reserve, 
free of preemptive rights and other preferential rights, a sufficient number 
of its authorized but unissued shares of Common Stock to satisfy the 
obligation of the Corporation to issue shares of Common Stock upon conversion 
of all Series B Shares. For purposes of this Agreement, any shares of Common 
Stock issuable upon conversion of the Series B Shares, and such shares when 
issued, are sometimes herein referred to as the "Conversion Shares".

         SECTION 3. SALE AND PURCHASE OF STOCK. The Corporation shall issue 
and sell to the Investor, and, subject to compliance with all of the terms 
and conditions hereof and in reliance on the representations, warranties and 
covenants set forth or referred to herein, the Investor shall purchase from 
the Corporation, the Series B Shares for the aggregate purchase price of 
$999,999. (the "Series B Purchase Price"). The closing of the sale and 
purchase of the Series B Shares (the "Closing") will occur on May 5, 1997 and 
will take place by facsimile transmission of executed copies of the documents 
contemplated hereby to the offices of Bingham, Dana & Gould LLP, 150 Federal 
Street, Boston, Massachusetts, at 10:00 a.m., local time, or at such other 
time as may be mutually agreed upon by the Investor and the Corporation. The 
date of the Closing is herein called the "Closing Date". At the Closing, the 
Corporation shall, unless otherwise requested, deliver to the Investor a 
single certificate evidencing the Series B Shares, against payment of the 
aggregate purchase price therefor by bank or certified check or wire transfer 
of immediately available funds to such account or accounts as the Corporation 
shall designate in writing.

                                       4

<PAGE>


         SECTION 4. REPRESENTATIONS AND WARRANTIES OF THE CORPORATION. The 
Corporation represents and warrants to the Investor that, except as set forth 
in the Disclosure Schedule attached hereto as Schedule 4 (which Disclosure 
Schedule makes explicit reference to the particular representation or 
warranty as to which exception is taken, which in each case shall constitute 
the sole representation and warranty as to which such exception shall apply):

         4.1.     Organization, Qualifications and Corporate Power.

                  (a) The Corporation is a corporation duly incorporated, 
validly existing and in good standing under the laws of the State of Delaware 
and is duly licensed or qualified to transact business as a foreign 
corporation and is in good standing in each jurisdiction in which the nature 
of the business transacted by it or the character of the properties owned or 
leased by it requires such licensing or qualification. The Corporation has 
the corporate power and authority to own and hold its properties and to carry 
on its business as now conducted and as proposed to be conducted, to execute, 
deliver and perform this Agreement and each of the other Related Documents, 
to issue, sell and deliver the Series B Shares, and to issue and deliver the 
Conversion Shares upon conversion of the Series B Shares.

                  (b) The attached Schedule 4.1(b) contains a list of all 
Subsidiaries of the Corporation. The Corporation does not (i) own of record 
or beneficially, directly or indirectly, (A) any shares of capital stock or 
securities convertible into capital stock of any other corporation or (B) any 
participating interest in any partnership, joint venture or other 
non-corporate business enterprise or (ii) control, directly or indirectly, 
any other entity.

         4.2.     Authorization of Agreements, Etc.

                  (a) The execution and delivery by the Corporation of this 
Agreement and each of the other Related Documents, the performance by the 
Corporation of its obligations hereunder and thereunder, the issuance, sale 
and delivery of the Series B Shares and the issuance and delivery of the 
Conversion Shares have been duly authorized by all requisite corporate action 
and will not violate any provision of law, any order of any court or other 
agency of government, the Restated Certificate of Incorporation or the 
By-laws of the Corporation, as amended, or any provision of any indenture, 
agreement or other instrument to which the Corporation or any of its 
properties or assets is bound, or conflict with, result in a breach of or 
constitute (with due notice or lapse of time or both) a default under any 
such indenture, agreement or other instrument, or result in the creation or 
imposition of any lien, charge, restriction, claim or encumbrance of any 
nature whatsoever upon any of the properties or assets of the Corporation.

                                       5

<PAGE>


                  (b) The Series B Shares have been duly authorized and, when 
issued in accordance with this Agreement, will be validly issued, fully paid 
and nonassessable shares of Series B Preferred Stock with no personal 
liability attaching to the ownership thereof and will be free and clear of 
all liens, charges, restrictions, claims and encumbrances imposed by or 
through the Corporation except as set forth in any of the other Related 
Documents. The Conversion Shares have been duly reserved for issuance upon 
conversion of the Series B Shares and, when so issued, will be duly 
authorized, validly issued, fully paid and nonassessable shares of Common 
Stock with no personal liability attaching to the ownership thereof and will 
be free and clear of all liens, charges, restrictions, claims and 
encumbrances imposed by or through the Corporation except as set forth in any 
of the other Related Documents. None of the issuance, sale or delivery of the 
Series B Shares or the issuance or delivery of the Conversion Shares is 
subject to any preemptive right of stockholders of the Corporation or to any 
right of first refusal or other right in favor of any Person.

         4.3. Validity. This Agreement has been duly executed and delivered 
by the Corporation and constitutes the legal, valid and binding obligation of 
the Corporation, enforceable in accordance with its terms. Each of the other 
Related Documents, when executed and delivered or filed, as the case may be, 
in accordance with this Agreement, will constitute the legal, valid and 
binding obligations of the Corporation, enforceable in accordance with their 
respective terms.

         4.4. Authorized Capital Stock. The authorized capital stock of the 
Corporation consists of (i) 700,000 shares of Preferred Stock, $.001 par 
value (the "Preferred Stock"), of which 200,000 have been designated as 
shares of Series A Preferred Stock and 500,000 have been designated as shares 
of Series B Preferred Stock, and (ii) 11,000,000 shares of Common Stock. 
Immediately prior to the Closing, 200,000 shares of Series A Preferred Stock 
and 2,140,000 shares of Common Stock will be validly issued and outstanding, 
fully paid and nonassessable with no personal liability attaching to the 
ownership thereof. The stockholders of record and holders of subscriptions, 
warrants, options, convertible securities, and other rights (contingent or 
other) to purchase or otherwise acquire equity securities of the Corporation, 
and the number of shares of Series A Preferred Stock or of Common Stock and 
the number of such subscriptions, warrants, options, convertible securities, 
and other such rights held by each, are as set forth in the attached Schedule 
4.4. The designations, powers, preferences, rights, qualifications, 
limitations and restrictions in respect of each class and series of 
authorized capital stock of the Corporation are as set forth in the 

                                       6

<PAGE>


Restated Certificate of Incorporation, and all such designations, powers, 
preferences, rights, qualifications, limitations and restrictions are valid, 
binding and enforceable and in accordance with all applicable laws. As of the 
date hereof, each outstanding share of Series A Preferred Stock is 
convertible into one share of Common Stock. Except as provided for in the 
Restated Certificate of Incorporation or as set forth in the attached 
Schedule 4.4, (i) no Person owns of record or is known to the Corporation to 
own beneficially any share of capital stock of the Corporation, (ii) no 
subscription, warrant, option, convertible security, or other right 
(contingent or other) to purchase or otherwise acquire equity securities of 
the Corporation is authorized or outstanding and (iii) there is no commitment 
by the Corporation to issue shares, subscriptions, warrants, options, 
convertible securities, or other such rights or to distribute to holders of 
any of its equity securities any evidence of indebtedness or asset. Except as 
provided for in the Restated Certificate of Incorporation or as set forth in 
the attached Schedule 4.4, the Corporation has no obligation (contingent or 
other) to purchase, redeem or otherwise acquire any of its equity securities 
or any interest therein or to pay any dividend or make any other distribution 
in respect thereof. Except as set forth in any of the Related Documents, to 
the best of the Corporation's knowledge, there are no voting trusts or 
agreements, stockholders' agreements, pledge agreements, buy-sell agreements, 
rights of first refusal, preemptive rights or proxies relating to any 
securities of the Corporation (whether or not the Corporation is a party 
thereto). All of the outstanding securities of the Corporation were issued in 
compliance with all applicable Federal and state securities laws.

         4.5. Financial Statements, Etc. The Corporation has furnished to the 
Investor the audited balance sheet of the Corporation as of December 31, 1996 
and the related audited statements of income, stockholders equity and cash 
flows of the Corporation for the year ended December 31, 1996, and the 
unaudited balance sheet of the Corporation as of March 31, 1997 (the "Balance 
Sheet") and the related unaudited statements of income, stockholders' equity 
and cash flows of the Corporation for the three months ended March 31, 1997. 
All such financial statements have been prepared in accordance with generally 
accepted accounting principles consistently applied (except that such 
unaudited financial statements do not contain all of the required footnotes) 
and fairly present the financial position of the Corporation as of December 
31, 1996 and March 31, 1997, respectively, and the results of their 
operations and cash flows for the year ended December 31, 1996 and the three 
months ended March 31, 1997, respectively. Since the date of the Balance 
Sheet, (i) there has been no change in the assets, liabilities or financial 
condition of the Corporation from that reflected in the Balance Sheet except 
for changes in the ordinary course of business which in the aggregate have 
not been materially adverse and (ii) none of the business, prospects, 
financial condition, operations, property or affairs of the Corporation has 
been materially adversely affected by any occurrence or development, 
individually or in the aggregate, whether or not insured against.

         4.6. Events Subsequent to the Date of the Balance Sheet. Since the 
date of the Balance Sheet, the Corporation has not (i) issued any stock, bond 
or other corporate security except as otherwise contemplated hereby, (ii) 
borrowed any amount or incurred or become subject to any liability (absolute, 
accrued or

                                       7

<PAGE>


contingent), except current liabilities incurred and liabilities under 
contracts entered into in the ordinary course of business, (iii) discharged 
or satisfied any lien or encumbrance or incurred or paid any obligation or 
liability (absolute, accrued or contingent) other than current liabilities 
shown on the Balance Sheet and current liabilities incurred since the date of 
the Balance Sheet in the ordinary course of business, (iv) declared or made 
any payment or distribution to stockholders or purchased or redeemed any 
share of its capital stock or other security, (v) mortgaged, pledged, 
encumbered or subjected to lien any of its assets, tangible or intangible, 
other than liens of current real property taxes not yet due and payable, (vi) 
sold, assigned or transferred any of its tangible assets except in the 
ordinary course of business, or canceled any debt or claim, (vii) sold, 
assigned, transferred or granted any exclusive license with respect to any 
patent, trademark, trade name, service mark, copyright, trade secret or other 
intangible asset, (viii) suffered any loss of property or waived any right of 
substantial value whether or not in the ordinary course of business, (ix) 
made any change in officer compensation except in the ordinary course of 
business and consistent with past practice, (x) made any material change in 
the manner of business or operations of the Corporation, (xi) entered into 
any transaction except in the ordinary course of business or as otherwise 
contemplated hereby or (xii) entered into any commitment (contingent or 
otherwise) to do any of the foregoing.

         4.7. Litigation; Compliance with Law. There is no (i) action, suit, 
claim, proceeding or investigation pending or, to the best of the 
Corporation's knowledge, threatened against or affecting the Corporation, at 
law or in equity, or before or by any Federal, state, municipal or other 
governmental department, commission, board, bureau, agency or 
instrumentality, domestic or foreign, (ii) arbitration proceeding relating to 
the Corporation pending under collective bargaining agreements or otherwise 
or (iii) governmental inquiry pending or, to the best of the Corporation's 
knowledge, threatened against or affecting the Corporation (including, 
without limitation, any inquiry as to the qualification of the Corporation to 
hold or receive any license, permit, or other authorization), and there is no 
basis for any of the foregoing. The Corporation has not received any opinion 
or memorandum or legal advice from legal counsel to the effect that it is 
exposed, from a legal standpoint, to any liability or disadvantage which may 
be material to its business, prospects, financial condition, operations, 
property or affairs. The Corporation is not in default with respect to any 
order, writ, injunction or decree known to or served upon the Corporation of 
any court or of any Federal, state, municipal or other governmental 
department, commission, board, bureau, agency or instrumentality, domestic or 
foreign. There is no action or suit by the Corporation pending or threatened 
against others. The Corporation has complied with all laws, rules, 
regulations and orders applicable to its business, operations, properties, 
assets, products and services, the Corporation has all necessary permits, 
licenses and other authorizations required to conduct its business as 
conducted and as proposed to be conducted, and the Corporation has been 
operating its business 

                                       8

<PAGE>


pursuant to and in compliance with the terms of all such permits, licenses 
and other authorizations. There is no existing law, rule, regulation or 
order, and the Corporation after due inquiry is not aware of any proposed 
law, rule, regulation or order, whether Federal, state, county or local, 
which would prohibit or restrict the Corporation from, or otherwise 
materially adversely affect the Corporation in, conducting its business in 
any jurisdiction in which it is now conducting business or in which it 
proposes to conduct business.

         4.8. Proprietary Information of Third Parties. To the best of the 
Corporation's knowledge, no third party has claimed or has reason to claim 
that any Person employed by or affiliated with the Corporation has (a) 
violated or may be violating any of the terms or conditions of his 
employment, non-competition or nondisclosure agreement with such third party, 
(b) disclosed or may be disclosing or utilized or may be utilizing any trade 
secret or proprietary information or documentation of such third party or (c) 
interfered or may be interfering in the employment relationship between such 
third party and any of its present or former employees. No third party has 
requested information from the Corporation which suggests that such a claim 
might be contemplated. To the best of the Corporation's knowledge, no Person 
employed by or affiliated with the Corporation has employed or proposes to 
employ any trade secret or any information or documentation proprietary to 
any former employer, and to the best of the Corporation's knowledge, no 
Person employed by or affiliated with the Corporation has violated any 
confidential relationship which such Person may have had with any third 
party, in connection with the development, manufacture or sale of any product 
or proposed product or the development or sale of any service or proposed 
service of the Corporation, and the Corporation has no reason to believe 
there will be any such employment or violation. To the best of the 
Corporation's knowledge, none of the execution or delivery of this Agreement 
or any of the other Related Documents by any officer, director or key 
employee of the Corporation, or the carrying on of the business of the 
Corporation as officers, employees or agents by such officer, director or key 
employee of the Corporation, will conflict with or result in a breach of the 
terms, conditions or provisions of or constitute a default under any 
contract, covenant or instrument under which any such officer, director or 
key employee is obligated.

         4.9. Patents, Trademarks Etc. Set forth in Schedule 4.9 attached 
hereto is a list and brief description of all domestic and foreign patents, 
patent rights, patent applications, trademarks, trademark applications, 
service marks, service mark applications, trade names and copyrights, and all 
applications for such which are in the process of being prepared, owned by or 
registered in the name of the Corporation, or of which the Corporation is a 
licensor or licensee or in which the Corporation has any right, and in each 
case a brief description of the nature of such right. The Corporation owns or 
possesses adequate licenses or other rights to use all patents, patent 
applications, trademarks, trademark applications, service 

                                       9

<PAGE>


marks, service mark applications, trade names, copyrights, manufacturing 
processes, formulae, trade secrets, customer lists and know how 
(collectively, "Intellectual Property") necessary to the conduct of its 
business as conducted and as proposed to be conducted, and no claim is 
pending or, to the best of the Corporation's knowledge, threatened to the 
effect that the operations of the Corporation infringe upon or conflict with 
the asserted rights of any other Person under any Intellectual Property, and 
there is no basis for any such claim (whether or not pending or threatened). 
No claim is pending or threatened to the effect that any such Intellectual 
Property owned or licensed by the Corporation, or which the Corporation 
otherwise has the right to use, is invalid or unenforceable by the 
Corporation, and there is no basis for any such claim (whether or not pending 
or threatened). To the best of the Corporation's knowledge, all technical 
information developed by and belonging to the Corporation which has not been 
patented has been kept confidential. The Corporation has not granted or 
assigned to any other Person or entity any right to manufacture, have 
manufactured, assemble or sell the products or proposed products or to 
provide the services or proposed services of the Corporation.

         4.10. Title to Properties. The Corporation has good, clear and 
marketable title to all of its properties and assets, including, without 
limitation, those reflected on the Balance Sheet or acquired by it since the 
date of the Balance Sheet (other than properties and assets disposed of in 
the ordinary course of business since the date of the Balance Sheet), and all 
of the Corporation's properties and assets are free and clear of mortgages, 
pledges, security interests, liens, charges, claims, restrictions and other 
encumbrances (including, without limitation, easements and licenses), except 
for liens for or current taxes not yet due and payable and minor 
imperfections of title, if any, not material in nature or amount and not 
materially detracting from the value or impairing the use of the property 
subject thereto or impairing the operations or proposed operations of the 
Corporation, including without limitation, the ability of the Corporation to 
secure financing using such properties and assets as collateral. To the best 
of the Corporation's knowledge after due inquiry, there are no condemnation, 
environmental, zoning or other land use regulation proceedings, either 
instituted or planned to be instituted, which would adversely affect the use 
or operation of the Corporation's properties and assets for their respective 
intended uses and purposes, or the value of such properties, and the 
Corporation has not received notice of any special assessment proceedings 
which would affect such properties and assets.

         4.11. Leasehold Interests. Each lease or agreement to which the 
Corporation is a party under which it is a lessee of any property, real or 
personal, is a valid and subsisting agreement, duly authorized and entered 
into, without any default of the Corporation thereunder and, to the best of 
the Corporation's knowledge, without any default thereunder of any other 
party thereto. No event has occurred and is continuing which, with due notice 
or lapse of time or both, 

                                       10

<PAGE>


would constitute a default or event of default by the Corporation under any 
such lease or agreement or, to the best of the Corporation's knowledge, by 
any other party thereto. The Corporation's possession of such property has 
not been disturbed and, to the best of the Corporation's knowledge after due 
inquiry, no claim has been asserted against the Corporation adverse to its 
rights in such leasehold interests.

         4.12. Insurance. Schedule 4.12 hereto lists all policies of fire, 
liability, workmen's compensation, life, property and casualty and other 
insurance owned or held by the Corporation. Such policies of insurance are 
maintained with financially sound and reputable insurance companies, funds or 
underwriters and are of the kinds and cover such risks and are in such 
amounts and with such deductibles and exclusions as are consistent with 
prudent business practice. All such policies (a) are in full force and 
effect, (b) are sufficient for compliance by the Corporation with all 
requirements of law and all agreements to which the Corporation is a party 
and (c) provide that they will remain in full force and effect through the 
respective dates set forth in such Schedule. The Corporation is not in 
default with respect to its obligations under any of such insurance policies 
and has not received any notification of cancellation of any such insurance 
policies.

         4.13. Taxes. The Corporation has filed all Returns required to be 
filed by it and has paid all Taxes shown to be due by such Returns, as well 
as all other Taxes, assessments and governmental charges which have become 
due or payable, including without limitation, all Taxes which it is obligated 
to withhold for amounts owing to employees, creditors and third parties. All 
Taxes with respect to which the Corporation has become obligated pursuant to 
elections made by it in accordance with generally accepted practice have been 
paid and adequate reserves have been established for all Taxes accrued but 
not yet payable. No issues have been raised (and are currently pending) by 
any taxing authority in connection with any of the Returns. No waivers of 
statutes of limitation with respect to any of the Returns have been given by 
or requested from the Corporation. All deficiencies asserted or assessments 
made as a result of any examinations have been fully paid, or are fully 
reflected as a liability in the financial statements of the Corporation, or 
are being contested and an adequate reserve therefor has been established and 
is fully reflected in the financial statements of the Corporation. There are 
no liens for Taxes (other than for current Taxes not yet due and payable) 
upon the assets of the Corporation. All material elections with respect to 
Taxes affecting the Corporation, as of the date hereof, are set forth in the 
financial statements of the Corporation, or are annexed hereto in a 
disclosure schedule. The Corporation has not agreed to make, nor is it 
required to make, any adjustment under Section 481(a) of the Code by reason 
of a change in accounting method or otherwise. The Corporation is not a party 
to any agreement, contract, arrangement or plan that has resulted or would 
result, separately or in the aggregate, in the payment of any "excess 
parachute payments" within the meaning of Section 28OG of the Code. The 
Corporation does not have and has not had a permanent establishment in any 
foreign country, as 

                                       11

<PAGE>  


defined in any applicable tax treaty or convention between the United States 
of America and such foreign country. Notwithstanding anything to the contrary 
contained in this Agreement, the provisions of this Section 4.13 shall 
survive until the applicable statutes of limitations with respect to any 
Taxes contemplated hereby shall have expired.

         4.14. Other Agreements. Except as set forth in the attached Schedule 
4.14(a), the Corporation is not a party to or otherwise bound by any written 
or oral agreement, instrument, commitment or restriction which individually 
or in the aggregate could materially adversely affect the business, 
prospects, financial condition, operations, property or affairs of the 
Corporation. Except as set forth in the attached Schedule 4.14(b), the 
Corporation is not a party to or otherwise bound by any written or oral:

                  (a) distributor, dealer, manufacturer's representative or 
sales agency agreement which is not terminable on less than ninety (90) days, 
notice without cost or other liability to the Corporation (except for 
agreements which, in the aggregate, are not material to the business of the 
Corporation);

                  (b) sales or service agreement which entitles any customer 
to a rebate or right of set-off, to return any product to the Corporation 
after acceptance thereof or to delay the acceptance thereof, or which varies 
in any material respect from the Corporation's standard form agreements;

                  (c) agreement with any labor union (and, to the best of the 
Corporation's knowledge, no organizational effort is being made with respect 
to any of its employees);

                  (d) agreement with any supplier containing any provision 
permitting any party other than the Corporation to renegotiate the price or 
other terms, or containing any payback or other similar provision, upon the 
occurrence of a failure by the Corporation to meet its obligations under the 
agreement when due or the occurrence of any other event;

                  (e) agreement for the future purchase of fixed assets or 
for the future purchase of materials, supplies or equipment in excess of its 
normal operating requirements;

                  (f) agreement for the employment of any officer, employee 
or other individual (whether of a legally binding nature or in the nature of 
informal understandings) on a full-time or consulting basis which is not 
terminable on notice without cost or other liability to the Corporation, 
except normal severance arrangements and accrued vacation pay;

                                       12

<PAGE>


                  (g) bonus, pension, profit-sharing, retirement, 
hospitalization, insurance, stock purchase, stock option or other plan, 
agreement or understanding pursuant to which benefits are provided to any 
employee of the Corporation (other than group insurance plans applicable to 
employees generally);

                  (h) agreement relating to the borrowing of money or to the 
mortgaging or pledging of, or otherwise placing a lien or security interest 
on, any asset of the Corporation;

                  (i) guaranty of any obligation for borrowed money or 
otherwise;

                  (j) voting trust or agreement, stockholders' agreement, 
pledge agreement, buy-sell agreement or first refusal or preemptive rights 
agreement relating to any securities of the Corporation;

                  (k) agreement, or group of related agreements with the same 
party or any group of affiliated parties, under which the Corporation has 
advanced or agreed to advance money or has agreed to lease any property as 
lessee or lessor;

                  (l) agreement or obligation (contingent or otherwise) to 
issue, sell or otherwise distribute or to repurchase or otherwise acquire or 
retire any share of its capital stock or any of its other equity securities;

                  (m) assignment, license or other agreement with respect to 
any form of intangible property;

                  (n) agreement under which it has granted any Person any 
registration rights, other than the Registration Rights Agreement;

                  (o) agreement under which it has limited or restricted its 
right to compete with any Person in any respect;

                  (p) other agreement or group of related agreements with the 
same party involving more than $10,000 or continuing over a period of more 
than six months from the date or dates thereof (including renewals or 
extensions optional with another party), which agreement or group of 
agreements is not terminable by the Corporation without penalty upon notice 
of thirty (30) days or less, but excluding any agreement or group of 
agreements with a customer of the Corporation for the sale, lease or rental 
of the Corporation's products or services if such agreement or group of 
agreements was entered into by the Corporation in the ordinary course of 
business; or

                  (q) other agreement, instrument, commitment, plan or 
arrangement, a copy of which would be required to be filed with the 
Securities and 

                                       13

<PAGE>


Exchange Commission (the "Commission") as an exhibit to a registration 
statement on Form S-1 if the Corporation were registering securities under 
the Securities Act.

         The Corporation and, to the best of the Corporation's knowledge 
after due inquiry, each other party thereto have in all material respects 
performed all the obligations required to be performed by them to date (or 
each non-performing party has received a valid, enforceable and irrevocable 
written waiver with respect to its non-performance), have received no notice 
of default and are not in default (with due notice or lapse of time or both) 
under any agreement, instrument, commitment, plan or arrangement to which the 
Corporation is a party or by which it or its property may be bound. The 
Corporation has no present expectation or intention of not fully performing 
all its obligations under each such agreement, instrument, commitment, plan 
or arrangement, and the Corporation has no knowledge of any breach or 
anticipated breach by the other party to any agreement, instrument, 
commitment, plan or arrangement to which the Corporation is a party. The 
Corporation is in full compliance with all of the terms and provisions of its 
Restated Certificate of Incorporation and By-laws, as amended.

         4.15. Loans and Advances. The Corporation does not have any 
outstanding loans or advances to any Person and is not obligated to make any 
such loans or advances, except, in each case, for advances to employees of 
the Corporation in respect of reimbursable business expenses anticipated to 
be incurred by them in connection with their performance of services for the 
Corporation.

         4.16. Assumptions, Guaranties, Etc. of Indebtedness of Other 
Persons. The Corporation has not assumed, guaranteed, endorsed or otherwise 
become directly or contingently liable on any indebtedness of any other 
Person (including, without limitation, liability by way of agreement, 
contingent or otherwise, to purchase, to provide funds for payment, to supply 
funds to or otherwise invest in the debtor, or otherwise to assure the 
creditor against loss), except for guaranties by endorsement of negotiable 
instruments for deposit or collection in the ordinary course of business.

         4.17. Significant Customers and Suppliers. No customer or supplier 
which was significant to the Corporation during the period covered by the 
financial statements referred to in Section 4.5 hereof or which has been 
significant to the Corporation thereafter, has terminated, materially reduced 
or threatened to terminate or materially reduce its purchases from or 
provision of products or services to the Corporation, as the case may be.

         4.18. Governmental Approvals. Subject to the accuracy of the 
representations and warranties of the Investor set forth in Section 5 of this 
Agreement, no registration or filing with, or consent or approval of or other 
action by, any Federal, state or other governmental agency or instrumentality 
is or will be necessary for the valid execution, delivery and performance by 
the Corporation of 

                                       14

<PAGE>


this Agreement or any of the other Related Documents, the issuance, sale and 
delivery of the Series B Shares or, upon conversion thereof, the issuance and 
delivery of the Conversion Shares, other than (i) filings pursuant to state 
securities laws (all of which filings have been made by the Corporation, 
other than those which are required to be made after the Closing and which 
will be duly made on a timely basis) in connection with the sale of the 
Series B Shares and (ii) with respect to the Registration Rights Agreement, 
the registration of the shares covered thereby with the Commission and 
filings pursuant to state securities laws.

         4.19. Issuance Taxes. There are no transfer, issuance or similar 
taxes imposed by law in connection with the issuance, sale or delivery of the 
Series B Shares or the Conversion Shares to the Investor.

         4.20. Offering of the Series B Shares. Neither the Corporation nor 
any Person acting on behalf of the Corporation has offered the Series B 
Shares or any security of the Corporation similar to the Series B Shares for 
sale to, or solicited any offer to buy the Series B Shares or any such 
similar security from, or otherwise approached or negotiated with respect 
thereto with, any Person or Persons, and neither the Corporation nor any 
Person acting on its behalf has taken or will take any other action 
(including, without limitation, any offer, issuance or sale of any security 
of the Corporation under circumstances which might require the integration of 
such security with the Series B Shares under the Securities Act or the rules 
and regulations of the Commission thereunder or under any applicable State 
securities laws), in either case so as to subject the offering, issuance or 
sale of the Series B Shares to the registration provisions of the Securities 
Act.

         4.21. Brokers. The Corporation has no contract, arrangement or 
understanding with any broker, finder or similar agent with respect to the 
transactions contemplated by this Agreement.

         4.22. Officers. Set forth in Schedule 4.22 attached hereto is a list 
of the names of the officers of the Corporation, together with the title or 
job classification of each such individual and the total compensation 
anticipated to be paid to each such individual by the Corporation in 1997. 
None of such individuals has an employment agreement or understanding, 
whether oral or written, with the Corporation, which is not terminable on 
notice by the Corporation without cost or other liability to the Corporation.

         4.23. Transactions With Affiliates. Except as set forth in Schedule 
4.23, no director, officer, employee or stockholder of the Corporation, or 
member of the family of any such Person, or any corporation, partnership, 
trust or other entity in which any such Person, or any member of the family 
of any such Person, has a substantial interest or is an officer, director, 
trustee, partner or holder of more than 5% of the outstanding capital stock 
thereof, is a party to any transaction with the 

                                       15

<PAGE>


Corporation, including any contract, agreement or other arrangement providing 
for the employment of, furnishing of services by, rental of real or personal 
property from or otherwise requiring payments to any such Person or firm.

         4.24. Employees. Each of the officers of the Corporation, each key 
employee or consultant and each other employee or consultant now employed by, 
or consulting for, the Corporation who has access to confidential information 
of the Corporation has executed a written confidentiality and nondisclosure 
agreement, and all of such agreements are in full force and effect. The 
Corporation has provided the Investor with copies of all of such written 
confidentiality and nondisclosure agreements. No officer or key employee or 
consultant of the Corporation has advised the Corporation (orally or in 
writing) that he intends to terminate his or her employment or consultancy, 
as the case may be, with the Corporation. The Corporation has complied in all 
material respects with all applicable laws relating to the employment of 
labor, including provisions relating to wages, hours, equal opportunity, 
collective bargaining and the payment of Social Security and other taxes, and 
with ERISA.

         4.25. U.S. Real Property Holding Corporation. The Corporation is not 
now and has never been a "United States real property holding corporation", 
as defined in Section 897(c)(2) of the Code and Section 1.897-2(b) of the 
Regulations promulgated by the Internal Revenue Service, and the Corporation 
has filed with the Internal Revenue Service all statements, if any, with its 
United States income tax returns which are required under Section 1.897-2(h) 
of such Regulations.

         4.26. Environmental Protection. The Corporation has not caused or 
allowed, or contracted with any party for, the generation, use, 
transportation, treatment, storage or disposal of any Hazardous Substances in 
connection with the operation of its business or otherwise. The Corporation, 
the operation of its business, and any real property that the Corporation 
owns, leases or otherwise occupies or uses (the "Premises") are in compliance 
with all applicable Environmental Laws and orders or directives of any 
governmental authorities having jurisdiction under such Environmental Laws, 
including, without limitation, any Environmental Laws or orders or directives 
with respect to any cleanup or remediation of any release or threat of 
release of Hazardous Substances. The Corporation has not received any 
citation, directive, letter or other communication, written or oral, or any 
notice of any proceeding, claim or lawsuit, from any Person arising out of 
the ownership or occupation of the Premises, or the conduct of its 
operations, and the Corporation is not aware of any basis therefor. The 
Corporation has obtained and is maintaining in full force and effect all 
necessary permits, licenses and approvals required by all Environmental Laws 
applicable to the Premises and the business operations conducted thereon 
(including operations conducted by tenants on the Premises), and is in 
compliance with all such permits, licenses and approvals. The Corporation has 
not caused or allowed a release, or a threat of release, of any Hazardous 
Substance 

                                       16

<PAGE>


onto, at or near the Premises, and, to the best of the Corporation's 
knowledge, neither the Premises nor any property at or near the Premises has 
ever been subject to a release, or a threat of release, of any Hazardous 
Substance.

         4.27. ERISA. Except as listed in Schedule 4.27, neither the 
Corporation nor any entity required to be aggregated with the Corporation 
under Sections 4.14(b), (c), (m) or (n) of the Code sponsors, maintains, has 
any obligation to contribute to, has any liability under, or is otherwise a 
party to, any Benefit Plan. With respect to each Benefit Plan listed in 
Schedule 4.27, to the extent applicable:

                  (a) Each such Benefit Plan has been maintained and operated 
in all material respects in compliance with its terms and with all applicable 
provisions of ERISA, the Code and all regulations, rulings and other 
authority issued thereunder;

                  (b) All contributions required by law to have been made 
under each such Benefit Plan (without regard to any waivers granted under 
Section 412 of the Code) to any fund or trust established thereunder or in 
connection therewith have been made by the due date thereof;

                  (c) Each such Benefit Plan intended to qualify under 
Section 401(a) of the Code is the subject of a favorable unrevoked 
determination letter issued by the Internal Revenue Service as to its 
qualified status under the Code, which determination letter may still be 
relied upon as to such tax qualified status, and no circumstances have 
occurred that would adversely affect the tax qualified status of any such 
Benefit Plan;

                  (d) The actuarial present value of all accrued benefits 
under each such Benefit Plan subject to Title IV of ERISA did not, as of the 
latest valuation date of such Benefit Plan, exceed the then current value of 
the assets of such Benefit Plan allocable to such accrued benefits, all as 
based upon the actuarial assumptions and methods currently used for such 
Benefit Plan;

                  (e) None of such Benefit Plans that are "employee welfare 
benefit plans" as defined in Section 3(l) of ERISA provides for continuing 
benefits or coverage for any participant or beneficiary of a participant 
after such participant's termination of employment; and

                  (f) Neither the Corporation nor any trade or business 
(whether or not incorporated) under common control with the Corporation 
within the meaning of Section 4001 of ERISA has, or at any time has had, any 
obligation to contribute to any "multiemployer plan" as defined in Section 
3(37) of ERISA.

                                       17

<PAGE>


         4.28. Foreign Corrupt Practices Act. The Corporation has not taken 
any action which would cause it to be in violation of the Foreign Corrupt 
Practices Act of 1977, as amended, or any rules and regulations thereunder. 
To the best of the Corporation's knowledge after due inquiry, there is not 
now, and there has never been, any employment by the Corporation of, or 
beneficial ownership in the Corporation by, any governmental or political 
official in any country in the world.

         4.29. Federal Reserve Regulations. The Corporation is not engaged in 
the business of extending credit for the purpose of purchasing or carrying 
margin securities (within the meaning of Regulation G of the Board of 
Governors of the Federal Reserve System), and no part of the proceeds of the 
Series B Shares will be used to purchase or carry any margin security or to 
extend credit to others for the purpose of purchasing or carrying any margin 
security or in any other manner which would involve a violation of any of the 
regulations of the Board of Governors of the Federal Reserve System.

         4.30. Indemnification of Directors and Officers. The By-Laws, as in 
effect on the date hereof, provide for the indemnification of officers and 
directors to the full extent permitted by the General Corporation Law of 
Delaware.

         4.31. Disclosure. Neither this Agreement, nor any Schedule or 
Exhibit to this Agreement, nor any of the financial statements delivered 
pursuant to Section 4.5 of this Agreement, nor the Business Plan of the 
Corporation dated November 25, 1996 (the "Business Plan"), contains an untrue 
statement of a material fact or omits a material fact necessary to make the 
statements contained herein or therein not misleading. None of the 
statements, documents, certificates or other items prepared or supplied by 
the Corporation with respect to the transactions contemplated hereby contains 
an untrue statement of a material fact or omits a material fact necessary to 
make the statements contained therein not misleading. There is no fact which 
the Corporation has not disclosed to the Investor and its counsel in writing 
and of which the Corporation is aware which materially and adversely affects 
or could materially and adversely affect the business, prospects, financial 
condition, operations, property or affairs of the Corporation.

         SECTION 5.  REPRESENTATIONS  AND WARRANTIES OF THE INVESTOR.  The 
Investor  represents and warrants to the Corporation that:

         5.1.     Organization, Authority, Binding Effect.

                  (a) It has full power and authority to enter into and 
perform this Agreement and the other Related Documents to which it is a 
party, in accordance with their respective terms. It is duly organized, 
validly existing and in good standing under the laws of its jurisdiction of 
organization and has the power and 

                                       18

<PAGE>


authority to enter into this Agreement and the other Related Documents to 
which it is a party.

                  (b) The execution, delivery and performance by it of this 
Agreement and the other Related Documents to which it is a party, and the 
consummation by it of the transactions contemplated hereby and thereby, have 
been duly authorized by all requisite action of it, and each such agreement 
or document constitutes the valid and binding obligation of the Investor, 
enforceable in accordance with its terms, except as such enforceability may 
be limited by applicable bankruptcy, insolvency, reorganization, moratorium 
or other laws of general application relating to or affecting the enforcement 
of creditors' rights and by the discretionary nature of equitable remedies, 
and except as rights to indemnity and contribution may be limited by 
applicable law.

         5.2.     Investment Representations.

                  (a)      The Investor represents and warrants to the 
                  Corporation as follows:

                           (i) It is acquiring the Series B Shares and, in the
                  event it should acquire Conversion Shares upon conversion of
                  the Series B Shares, it will be acquiring such Conversion
                  Shares, for its own account, for investment and not with a
                  view to the distribution thereof within the meaning of the
                  Securities Act.

                           (ii) It is an "accredited investor" as such term is
                  defined in Rule 501 (a) promulgated under the Securities Act.

                           (iii) It agrees that the Corporation may place a
                  legend on the certificates delivered hereunder stating that
                  the Series B Shares and any Conversion Shares have not been
                  registered under the Securities Act, and, therefore, cannot be
                  offered, sold or transferred unless they are registered under
                  the Securities Act or an exemption from such registration is
                  available, and that the Corporation may place stop transfer
                  orders on the transfer books of the Corporation.

                           (iv) It further understands that the exemptions from
                  registration afforded by Rule 144 and Rule 144A (the
                  provisions of each of which are known to it) promulgated under
                  the Securities Act depend on the satisfaction of various
                  conditions, and that, if applicable, Rule 144 may afford the
                  basis for sales only in limited amounts.

                           (v) It has such knowledge and experience in business
                  and financial matters and with respect to investments in
                  securities of 

                                       19

<PAGE>


                  privately-held companies so as to enable it to
                  understand and evaluate the risks of the Investor's investment
                  in the Series B Shares and the Conversion Shares and form an
                  investment decision with respect thereto. It has been afforded
                  the opportunity during the course of negotiating the
                  transactions contemplated by this Agreement to ask questions
                  of, and to secure such information from, the Corporation and
                  its officers and directors as it deemed necessary to evaluate
                  the merits of entering into such transactions.

                           (vi) It has adequate net worth and means of providing
                  for its current needs and contingencies to sustain a complete
                  loss of its investment in the Corporation.

                  (b) The Investor further represents and warrants to the 
Corporation that: (i) it is a Delaware corporation, (ii) it was not formed 
for the specific purpose of acquiring any of the Series B Shares or the 
Conversion Shares, (iii) it has assets in excess of $5,000,000 and (iv) its 
principal office is located in Cambridge, Massachusetts.

         5.3. Brokers. The Investor has not retained, utilized or been 
represented by any broker or finder in connection with the transactions 
contemplated by this Agreement.

         SECTION 6. CONDITIONS TO THE OBLIGATIONS OF THE INVESTOR. The 
obligation of the Investor to purchase and pay for the Series B Shares is 
subject to the satisfaction, on or before such Closing Date, of the following 
conditions (unless waived in writing by the Investor):

         6.1 Representations and Warranties to be True and Correct. The 
representations and warranties contained in Section 4 hereof shall be true, 
complete and correct on and as of the Closing Date with the same effect as 
though such representations and warranties had been made on and as of the 
Closing Date, and the President and Treasurer of the Corporation shall have 
certified to such effect to the Investor in writing.

         6.2 Performance. The Corporation shall have performed and complied 
with all agreements contained herein required to be performed or complied 
with by it prior to or at the Closing, and the President and Treasurer of the 
Corporation shall have certified to the Investor in writing to such effect 
and to the further effect that all of the conditions set forth in this 
Section 6 have been satisfied.

         6.3 Investors' Rights Agreement. The Corporation and the Investor 
shall have executed and delivered the Investors' Rights Agreement.

                                       20

<PAGE>


         6.4 Stock Restriction Agreement. The Corporation, the Management 
Stockholders and the Investor shall have executed and delivered the Stock 
Restriction Agreement.

         6.5 Registration Rights Agreement. The Corporation and the Investor 
shall have executed and delivered the Registration Rights Agreement.

         6.6 Nondisclosure and Invention Assignment Agreements. Each of the 
Corporation's officers, key employees or consultants and employees and 
consultants having access to confidential information of the Corporation 
shall have executed and delivered to the Corporation a written nondisclosure 
and invention assignment agreement in form and substance satisfactory to the 
Investor, and copies thereof have been delivered to counsel for the Investor.

         6.7  Restated Certificate of Incorporation. The Restated Certificate 
of Incorporation shall have been duly executed and shall have been filed with 
the Secretary of State of Delaware and shall be in full force and effect.

         6.8  Preemptive Rights. All stockholders of the Corporation having 
any preemptive, first refusal or other right with respect to the issuance of 
the Series B Shares or Conversion Shares shall have irrevocably waived the 
same in writing.

         6.9  Opinion of Corporation's Counsel. The Corporation shall have 
delivered to the Investor an opinion from Jenner & Block, counsel to the 
Corporation, in form and substance satisfactory to the Investor and its 
counsel.

         6.10 Supporting Documents. The Corporation shall have delivered to 
the Investor and its counsel copies of the following documents:

                           (a) the Restated Certificate of 
                  Incorporation, certified as of a recent date by
                  the Secretary of State of the State of Delaware;

                           (b) a certificate of the Secretary of State of
                  Delaware, dated as of a recent date, as to the due
                  incorporation and good standing of the Corporation, the
                  payment of all excise taxes by the Corporation and listing all
                  documents of the Corporation on file with said Secretary;

                           (c) a certificate of the Secretary or an Assistant
                  Secretary of the Corporation, dated the Closing Date, and
                  certifying: (A) that attached thereto is a true and complete
                  copy of the By-laws of the Corporation as in effect on the
                  date of such certification; (B) that attached thereto is a
                  true and complete copy of all resolutions adopted by the Board
                  of Directors and/or stockholders of the Corporation

                                       21

<PAGE>


                  authorizing the execution, delivery and performance of this
                  Agreement, the other Related Documents, the issuance, sale and
                  delivery of the Series B Shares, the reservation, issuance and
                  delivery of the Conversion Shares and that all such
                  resolutions are in full force and effect and are all the
                  resolutions adopted in connection with the transactions
                  contemplated by this Agreement and the other Related
                  Documents; (C) that the Restated Certificate of Incorporation
                  has not been amended since the date of the last amendment
                  referred to in the certificate delivered pursuant to clause
                  (b) above; and (D) to the incumbency and specimen signature of
                  each officer of the Corporation executing this Agreement, the
                  other Related Documents, the stock certificates representing
                  the Series B Shares and any certificate or instrument
                  furnished pursuant hereto, and a certification by another
                  officer of the Corporation as to the incumbency and signature
                  of the officer signing the certificate referred to in this
                  clause (c); and

                           (d) such additional supporting documents and other
                  information with respect to the operations and affairs of the
                  Corporation as the Investor or its counsel reasonably may
                  request.

         6.11 No Adverse Change. There shall not have been any material 
adverse change in the Corporation, its business, financial condition, 
operations or prospects.

         6.12 Litigation. No proceeding challenging this Agreement or any of 
the other Related Documents, or any of the transactions contemplated hereby 
or thereby, or seeking to prohibit, alter, prevent or materially delay the 
Closing, shall have been instituted before any court, arbitrator or 
governmental body, agency or official and shall be pending.

         6.13 Compliance with Laws; Governmental Consents and Approvals. The 
purchase of and payment for the Series B Shares by the Investor shall not be 
prohibited by any law or governmental order or regulation; and all necessary 
consents, approvals, licenses, permits, orders and authorizations of, or 
registrations, declarations and filings with, any governmental or 
administrative agency or of any other Person with respect to any of the 
transactions contemplated under this Agreement or any of the other Related 
Documents shall have been duly obtained or made and shall be in full force 
and effect.

         6.14 All Proceedings to be Satisfactory. All corporate and other 
proceedings to be taken by the Corporation in connection with the 
transactions contemplated hereby and all documents incident thereto shall be 
satisfactory in form and substance to the Investor and its counsel, and the 
Investor and their counsel shall have received all such counterpart originals 
or certified or other copies of such documents as they reasonably may request.

                                       22

<PAGE>


         SECTION 7.  RESEARCH COLLABORATION.

         7.1      Collaboration.

                  (a) The Corporation and the Investor hereby agree (i) to 
engage in the Collaborative "BioKeys" Research Project and the 
"ElectroScreen" Research Project, all as described in Exhibit F attached 
hereto, (ii) to engage in the research activities described in Section 7.1(c) 
below and (iii) to engage in such other research activities as the parties 
may agree upon from time to time. For purposes hereof, the term 
"Collaboration" shall mean the collaboration and other research activities 
engaged in by the parties pursuant to this Section 7. The terms and 
conditions of the Collaboration and of all research activities of the parties 
pursuant to the Collaboration shall be governed by, to the extent applicable, 
the provisions of this Section 7, the provisions of Exhibit F attached hereto 
and such other provisions as the parties may agree upon in writing from and 
after the date hereof. The term of the Collaboration (the "Term") shall 
commence on the date hereof and end on February 5, 2001, provided that the 
Investor shall be entitled to terminate the Collaboration at any time from 
and after November 5, 1997 by giving the Corporation at least thirty (30) 
days prior written notice of termination. For purposes of this Agreement, (A) 
the term "Collaboration Termination Date" shall mean the earlier of (i) 
February 5, 2001 or (ii) the effective date of termination of the 
Collaboration pursuant to the provisions of this Section 7.1(a), (B) the term 
"Minimum Research Period" shall mean the period commencing on the date hereof 
and ending on the earlier of (i) the Collaboration Termination Date or (ii) 
May 5, 1998 (the "Acquisition Option Expiration Date"), and (C) the term 
"Remaining Research Period" shall mean the period commencing on May 5, 1998 
and ending on the Collaboration Termination Date.

                  (b) During the Minimum Research Period, the Corporation and 
the Investor shall engage in the research activities described in Exhibit F 
attached hereto. The respective tasks, activities and obligations of the 
parties during the Minimum Research Period are set forth in Exhibit F 
attached hereto.

                  (c) In the event that the Investor elects not to exercise 
the Acquisition Option, the Investor shall, within thirty (30) days after the 
Acquisition Option Expiration Date, deliver to the Corporation a schedule 
listing all of the research programs then being conducted by the Investor 
(the "Specified Research Programs"). During the Remaining Research Period, 
the Corporation and the Investor shall (i) continue the research activities 
described in Exhibit F, (ii) engage in such research, screening, target 
discovery and validation, and drug discovery and development activities as 
the Investor shall request, provided that such research, screening, target 
discovery and validation and drug discovery and development activities are 
related to, or involve, biological targets that are within the scope of 

                                       23

<PAGE>


the Specified Research Programs and (iii) engage in such other research 
activities as the parties may agree from time to time. The respective tasks, 
activities and obligations of the parties in connection with any of the 
matters on which the parties are collaborating during the Remaining Research 
Period shall be mutually agreed upon by the parties.

         7.2      Funding.

                  (a) On the first day of each month during the Minimum 
Research Period and on the first day of the first month immediately after the 
Minimum Research Period, the Investor shall reimburse the Corporation for any 
payments made by the Corporation during the immediately preceding month in 
respect of (i) salary and fringe benefits payable by the Corporation to no 
more than two scientists and one technician employed by the Corporation and 
engaged solely in activities relating the Collaboration, and (ii) laboratory 
supplies for use solely in activities relating to the Collaboration; 
provided, however, that the amount of any monthly payment that the Investor 
shall be required to make to the Corporation pursuant to the foregoing 
provisions of this Section 7.2(a) shall in no event exceed $18,334 (it being 
understood that any expenses incurred or payments made by the Corporation in 
connection with the Collaboration in any month during the Minimum Research 
Period in excess of $18,334 shall be the Corporation's sole responsibility 
and the Investor shall have no obligation to reimburse the Corporation with 
respect to any such excess). In addition, the Investor shall reimburse the 
Corporation for up to a total of $30,000 of travel expenses incurred by the 
Corporation in connection with travel by officers or employees of the 
Corporation in the performance of tasks and duties pertaining to the 
Collaboration, provided that such travel expenses are incurred by the 
Corporation, and are submitted by the Corporation for reimbursement, in 
accordance with the Investor's policy on reimbursable travel expenses that is 
applicable to all officers and employees of the Investor.

                  (b) On the first day of each month during the Remaining 
Research Period and on the first day of the first month immediately after the 
Remaining Research Period, the Investor shall reimburse the Corporation for 
the direct costs incurred by the Corporation in connection with activities 
relating to the Collaboration, provided that such costs shall not exceed the 
amount budgeted for such costs by mutual agreement of the Investor and the 
Corporation (it being understood that any costs incurred by the Corporation 
in connection with the Collaboration activities that are in excess of the 
amount budgeted by the parties for such costs shall be the Corporation's sole 
responsibility and the Investor shall have no obligation to reimburse the 
Corporation with respect to any such excess).

                  (c) The Investor shall also pay to the Corporation seven 
percent (7%) of all revenue actually received by the Investor from third 
parties to the extent that such revenue is directly attributable to (i) the 
sale of a third party anti-

                                       24

<PAGE>


bacterial or anti-fungal drug that was discovered or developed as a result of 
the use of the Licensed Technology (as defined in Section 7.5 hereof), (ii) 
drug development milestone payments actually received by the Investor on 
account of any anti-bacterial or anti-fungal drug candidate that was 
discovered or developed as a result of the use of the Licensed Technology, 
and (iii) any licensing fees actually received by the Investor with respect 
to any sublicense of the Licensed Technology.

         7.3 Obligations Following Termination of Collaboration. Except for 
the Investor's obligation, pursuant to Section 7.2(a) above, to make a 
payment to the Corporation on the first day of the first month immediately 
after the Minimum Research Period and except for any other payment 
obligations of the Investor in connection with the Collaboration which are 
agreed upon by the parties in writing after the date hereof and which by 
their own terms survive the Collaboration Termination Date, the Investor 
shall have no obligations or liabilities to the Corporation pursuant to this 
Section 7 (including, without limitation, the obligation to make payments to 
the Corporation in connection with the Collaboration) from and after the 
Collaboration Termination Date.

         7.4 Exclusivity.

                  (a) Until the later of (i) the expiration of the 
Acquisition Option Period or (ii) if the Acquisition Option is exercised, the 
closing of the Acquisition, the Corporation shall not engage in any research 
or screening activities or programs, any research collaboration, any drug 
discovery or drug development collaboration, partnership or alliance, any 
licensing transaction, or any other kind of transaction, involving all or any 
portion of the Corporation's intellectual property or know-how or the 
intellectual property or know-how of any Person; provided, however, that the 
foregoing provisions of this Section 7.4(a) shall not preclude the 
Corporation from engaging in (i) the Collaboration or (ii) any research or 
screening activities or programs set forth in Schedule 7.4(a) attached 
hereto, all of which are research or screening activities or programs in 
which the Corporation is currently involved as of the date of this Agreement. 
The restrictions set forth in this Section 7.4(a) may be waived, in any 
instance, by written consent of the Investor.

                  (b) During the period commencing upon the expiration of the 
restrictions set forth in Section 7.4(a) above and ending on the 
Collaboration Termination Date, the Corporation shall not engage in any 
research or screening activities or programs, any research collaborations, 
any drug discovery or drug development collaborations, partnerships or 
alliances, any licensing transactions, or any other kind of transactions, in 
the anti-bacterial and/or anti-fungal therapeutic area; provided, however, 
that the foregoing provisions of this Section 7.4(b) shall not preclude the 
Corporation from engaging in (i) the Collaboration, (ii) any research or 
screening activities or programs set forth in Schedule 7.4(b) attached 
hereto, all of which are research or screening activities or programs in 
which the Corporation is 

                                       25

<PAGE>


currently involved as of the date of this Agreement or (iii) any research or 
screening activity or program so long as it (A) covers a finite number of 
specific biological targets for drug discovery and development, (B) provides 
for the Corporation to engage in active research, discovery and development 
activities with respect to all of such biological targets, (C) provides for 
the payment to the Corporation of commercially reasonable consideration and 
(D) does not preclude the Corporation from entering into similar arrangements 
with other parties (including the Investor) relating to other targets in the 
same or any different field or pathogen. The restrictions set forth in this 
Section 7.4(b) may be waived, in any instance, by written consent of the 
Investor.

                  (c) Until the later of (i) the expiration of the 
Acquisition Option Period or (ii) if the Acquisition Option is exercised, the 
closing of the Acquisition, the Corporation, subject to any applicable 
nondisclosure agreements between the Corporation and third parties, shall 
discuss and coordinate in advance with the Investor any contacts, meetings, 
discussions or negotiations that the Corporation proposes to make or in which 
the Corporation proposes to participate, to the extent that such proposed 
contacts, meetings, discussions or negotiations relate to any research or 
screening activities or programs, any research collaboration, any drug 
discovery or drug development collaboration, partnership or alliance, any 
licensing transaction, or any other kind of transaction, involving all or any 
portion of the Corporation's intellectual property or know-how or the 
intellectual property or know-how of any Person; provided, however, that the 
foregoing provisions of this Section 7.4(c) shall not apply to (i) the 
Collaboration or (ii) any research or screening activities or programs set 
forth in Schedules 7.4(a) or 7.4(b) attached hereto, all of which are 
research or screening activities or programs in which the Corporation is 
currently involved as of the date of this Agreement.

         7.5 License. Subject to the provisions of this Section 7.5 hereof, 
the Corporation hereby grants to the Investor a worldwide license (the 
"License") to use any and all inventions, technology, know-how and 
intellectual property of the Corporation (collectively, the "Licensed 
Technology") for purposes of (i) researching, screening for, discovering or 
developing anti-bacterial or anti-fungal drug candidates or anti-bacterial or 
anti-fungal drug discovery targets or (ii) selling, licensing, marketing or 
otherwise commercializing anti-bacterial or anti-fungal drugs discovered or 
developed using any portion of the Licensed Technology during the Term. 
Without limiting the generality of the definition of the term "Licensed 
Technology" set forth above, such term shall include any patent or patent 
applications of the Corporation and any inventions, technology or know-how 
disclosed in such patents or patent applications. The License shall be 
perpetual and irrevocable. The License shall be exclusive to the extent and 
for the period of time that the Corporation has agreed to abide by the 
exclusivity provisions of Section 7.4 above. The Investor shall have the 
right to sublicense the License and the Licensed Technology. Except for any 
payments made or required to be made by the Investor 

                                       26

<PAGE>


to the Corporation pursuant to Section 7.2 above in connection with the 
Collaboration, the Investor shall not have to pay or otherwise owe to the 
Corporation any consideration of any kind in connection with the License.

         7.6 Collaborative Research Agreement. The parties hereby acknowledge 
that the foregoing provisions of this Section 7 do not address all of the 
matters with respect to the Collaboration that would customarily be addressed 
in a stand-alone collaborative research agreement. Accordingly, the parties 
hereby agree that, within sixty (60) days after the Closing Date, the parties 
shall negotiate and enter into a collaborative research agreement with 
respect to the Collaboration (the "Collaborative Agreement"), which 
Collaborative Agreement shall contain terms and provisions that are 
consistent with all of the provisions set forth above in this Section 7 and 
such other terms and provisions as are customary for research collaborations 
similar to the Collaboration. In the event that the parties fail to reach 
agreement with respect to the terms and conditions of the Collaborative 
Agreement, the respective Chief Executive Officers of the parties shall, 
within thirty (30) days after the expiration of such sixty (60) day period, 
meet and negotiate in good faith a resolution of the parties' differences. If 
the parties' respective Chief Executive Officers are unable to resolve the 
parties' differences, then such differences shall be submitted to binding 
arbitration as provided in Section 7.7 below. Upon execution and delivery by 
both parties of the Collaborative Agreement, the provisions of this Section 7 
shall terminate and be superseded by the provisions of the Collaborative 
Agreement. Nothing in this Section 7.6 shall be construed as limiting the 
enforceability, validity or binding effect of any of the other provisions of 
this Section 7.

         7.7 Arbitration. If the parties are unable to agree on the terms and 
conditions of the Collaborative Agreement contemplated by Section 7.6 above 
prior to or during the thirty (30) day period referred to in Section 7.6 
above, the dispute issues shall be submitted to binding arbitration. The 
parties shall select one arbitrator, provided that, if the parties cannot 
agree on the arbitrator, each party shall select an arbitrator, and these two 
arbitrators will then select a third arbitrator. The arbitrator or 
arbitrators shall be accredited by the American Arbitration Association and 
shall be individuals with relevant business experience in structuring and 
negotiating biotechnology research collaborations; provided, however, that 
the parties may mutually agree in writing to waive either or both of the 
foregoing requirements. The arbitration shall be held in Boston, 
Massachusetts or in such other city in the United States as the parties may 
mutually agree. The arbitration session will be held no later than thirty 
(30) days after the expiration of the thirty (30) day period referred to in 
Section 7.6 above. The arbitrator or arbitrators shall render a decision 
within ten (10) business days of the conclusion of the arbitration session. 
The arbitration proceeding shall be conducted in accordance with the rules of 
the American Arbitration Association. The decision of the arbitrator or 
arbitrators shall be final and binding on both parties. If the

                                       27

<PAGE>


parties are able to agree on the appointment of a single arbitrator, then the 
cost of such arbitrator shall be shared equally by both parties. If the 
parties are unable to agree on the appointment of a single arbitrator, each 
party shall bear the cost of the arbitrator appointed by such party and the 
cost of the third arbitrator shall be shared equally by both parties. Each 
party shall be responsible for all costs incurred by it in preparing for and 
participating in the arbitration.

         7.8 Termination. The provisions of this Section 7 shall 
automatically terminate upon consummation of the Acquisition.

         SECTION 8. USE OF PROCEEDS. The Corporation shall use the proceeds 
from the sale of the Series B Shares solely for working capital in the 
ordinary course of its business as currently conducted by the Corporation.

         SECTION 9. RESTRICTIONS ON TRANSFER. The Series B Shares and the 
Conversion Shares shall be subject to the restrictions on transfer set forth 
in Section 4 of the Investors' Rights Agreement.

         SECTION 10. INDEMNIFICATION. The Corporation agrees to indemnify, 
defend and hold the Investor (and its directors, officers, employees, agents 
and affiliates and the directors, officers, employees and agents of such 
affiliates) harmless against any and all liabilities, losses, costs or 
damages, together with all reasonable costs and expenses related thereto 
(including reasonable legal and accounting fees and expenses), incurred or 
suffered by any such indemnified Person arising from, relating to, or in 
connection with the untruth, inaccuracy or breach of any statements, 
representations, warranties or covenants of the Corporation contained herein. 
The Investor agrees to indemnify, defend and hold the Corporation (and its 
directors, officers, employees, agents and affiliates and the directors, 
officers, employees and agents of such affiliates) harmless against any and 
all liabilities, losses, costs or damages, together with all reasonable costs 
and expenses related thereto (including reasonable legal and accounting fees 
and expenses), incurred or suffered by any such indemnified Person arising 
from, relating to, or in connection with the untruth, inaccuracy or breach of 
any statements, representations, warranties or covenants of the Investor 
contained herein. Indemnification pursuant to this Section 10 shall be in 
addition to any liability the Corporation or the Investor may otherwise have.

                                       28

<PAGE>


         SECTION 11.  GENERAL.

         11.1 Election to Board of Directors. The Corporation shall use its 
best efforts to cause a representative of the Investor to be elected as a 
director of the Corporation within thirty days after the Closing Date.

         11.2 Expenses. Each party hereto will pay its own expenses in 
connection with the transactions contemplated hereby, whether or not such 
transactions shall be consummated; provided, however, that, at the Closing, 
the Investor shall reimburse the Corporation, up to a maximum aggregate 
amount of $10,000, for any amounts paid or payable by the Corporation in 
respect of the reasonable fees, expenses and disbursements of the 
Corporation's outside legal, accounting and tax advisors but only if and to 
the extent that (i) such reasonable fees, expenses and disbursements pertain 
to the transactions contemplated by this Agreement and the Related Documents 
and (ii) the Corporation provides the Investor with a copy of the invoices 
submitted to the Corporation by such advisors and such invoices are 
sufficiently detailed to adequately support the amount of such fees, expenses 
and disbursements.

         11.3 Survival of Agreements. All covenants, agreements, 
representations and warranties made herein or in any of the other Related 
Documents, or any certificate or instrument delivered to the Investor 
pursuant to or in connection with this Agreement or any of the other Related 
Documents, shall survive the execution and delivery of this Agreement and 
each of the other Related Documents, the issuance, sale and delivery of the 
Series B Shares and the issuance and delivery of the Conversion Shares, and 
all statements contained in any certificate or other instrument delivered by 
the Corporation hereunder or thereunder or in connection herewith or 
therewith shall be deemed to constitute representations and warranties made 
by the Corporation.

         11.4 Brokerage. Each party hereto will indemnify and hold harmless 
the others against and in respect of any claim for brokerage or other 
commissions relative to this Agreement or to the transactions contemplated 
hereby, based in any way on agreements, arrangements or understandings made 
or claimed to have been made by such party with any third party.

         11.5 Parties in Interest. All representations, covenants and 
agreements contained in this Agreement by or on behalf of any of the parties 
hereto shall bind and inure to the benefit of the respective successors and 
permitted assigns of the parties hereto whether so expressed or not. Without 
limiting the generality of the foregoing, all representations, covenants and 
agreements benefiting the Investor shall inure to the benefit of any and all 
subsequent holders from time to time of Series B Shares or Conversion Shares.

                                       29

<PAGE>


         11.6 Assignment. This Agreement and the respective rights and 
obligations of the parties hereto may not be assigned or delegated, except to 
the extent otherwise consented to in writing by the Corporation and the 
Investor and except that, after the Closing, the Investor may assign all of 
its rights under this Agreement to any Person.

         11.7 Remedies. In case that any one or more of the covenants and/or 
agreements set forth in this Agreement shall have been breached by any party 
hereto, the party or parties entitled to the benefit of such covenants or 
agreements may proceed to protect and enforce its or their rights, either by 
suit in equity and/or action at law, including, but not limited to, an action 
for damages as a result of any such breach and/or an action for specific 
performance of any such covenant or agreement contained in this Agreement. 
The rights, powers and remedies of the parties to this Agreement are 
cumulative and not exclusive of any other right, power or remedy which such 
parties may have under any other agreement or law. No single or partial 
assertion or exercise of any right, power or remedy of a party hereunder 
shall preclude any other or further assertion or exercise thereof.

         11.8 Entire Agreement. This Agreement contains the entire agreement 
among the parties with respect to the subject matter hereof and supersedes 
all prior and contemporaneous arrangements or understandings with respect 
thereto.

         11.9 Notices. All notices, requests, consents and other 
communications hereunder to any party shall be deemed to be sufficient if 
contained in a written instrument delivered in person or duly sent by first 
class, registered, certified or overnight mail, postage prepaid, or 
telecopied with a confirmation copy by regular mail, addressed or telecopied, 
as the case may be, to such party at the address or telecopier number, as the 
case may be, set forth below or such other address or telecopier number, as 
the case may be, as may hereafter be designated in writing by the addressee 
to the addresser listing all parties:

         (i)  If to the Corporation to:

                                      Novalon Pharmaceutical Corporation
                                      214 West Cameron Avenue, Suite B
                                      Chapel Hill, N.C. 27516
                                      Attention: Dana M. Fowlkes, M.D., Ph.D.,
                                                 President & CEO
                                      Telecopier:(919) 968-9255

                                       30

<PAGE>


                                      with a copy to:

                                      Jenner & Block
                                      12th Floor
                                      601 Thirteenth Street, N.W.
                                      Washington, D.C. 20005
                                      Attention:  D. Joe Smith
                                      Telecopier: (203) 639-6066

         (ii) If to the Investor, to:

                                      Cubist Pharmaceuticals, Inc.
                                      24 Emily Street
                                      Cambridge, MA 02139
                                      Attention:  Scott M. Rocklage, Ph.D.
                                      Telecopier: (617) 576-0232

                                      with a copy to:

                                      Bingham, Dana & Gould LLP
                                      150 Federal Street
                                      Boston, MA 02110-1726
                                      Attention:  Julio E. Vega, Esquire
                                      Telecopier: (617) 951-8736


Any notice or other communication pursuant to this Agreement shall be deemed 
to have been duly given or made and to have become effective (i) when 
delivered in hand to the party to which it was directed, (ii) if sent by 
telex, telecopier, facsimile machine or telegraph and properly addressed in 
accordance with the foregoing provisions of this Section 11.9, when received 
by the addressee, (iii) if sent by commercial courier guaranteeing next 
business day delivery, on the business day following the date of delivery to 
such courier, or (iii) if sent by first-class mail, postage prepaid, and 
properly addressed in accordance with the foregoing provisions of this 
Section 11.9, (A) when received by the addressee, or (B) on the third 
business day following the day of dispatch thereof, whichever of (A) or (B) 
shall be the earlier.

         11.10 Amendments and Waivers. Any provision of this Agreement may be 
amended, modified or terminated, and the observance of any provision of this 
Agreement may be waived (either generally or in a particular instance and 
either retrospectively or prospectively), with, but only with, the written 
consent of each of the parties hereto.

                                       31

<PAGE>


         11.11 Severability. Any provision of this Agreement that is 
prohibited or unenforceable in any jurisdiction shall, as to such 
jurisdiction, be ineffective to the extent of such prohibition or 
unenforceability without invalidating the remaining provisions hereof, and 
any such prohibition or unenforceability in any jurisdiction shall not 
invalidate or render unenforceable such provision in any other jurisdiction.

         11.12 No Waiver of Future Breach. No failure or delay on the part of 
any party to this Agreement in exercising any right, power or remedy 
hereunder shall operate as a waiver thereof. No assent, express or implied, 
by any party hereto to any breach in or default of any agreement or condition 
herein contained on the part of any other party hereto shall constitute a 
waiver of or assent to any succeeding breach in or default of the same or any 
other agreement or condition hereof by such other party.

         11.13 No Implied Rights or Remedies; Third Party Beneficiaries. 
Except as otherwise expressly provided in this Agreement, nothing herein 
expressed or implied is intended or shall be construed to confer upon or to 
give any Person, firm or corporation, other than the Corporation and the 
Investor, any rights or remedies under or by reason of this Agreement. Except 
as otherwise expressly provided in this Agreement, there are no intended 
third party beneficiaries under or by reason of this Agreement.

         11.14 Headings. The headings of the various sections of this 
Agreement have been inserted for convenience of reference only and shall not 
be deemed to be a part of this Agreement.

         11.15 Nouns and Pronouns. Whenever the context may require, any 
pronouns used herein shall include the corresponding masculine, feminine or 
neuter forms, and the singular form of names and pronouns shall include the 
plural and vice-versa.




                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       32

<PAGE>


         11.16 Governing Law. This Agreement shall be governed by and construed
in accordance with the laws of the State of Delaware, excluding the choice of
law rules thereof.

         11.17 Counterparts. This Agreement may be executed in any number of
counterparts, and each such counterpart shall be deemed to be an original
instrument, but all such counterparts together shall constitute but one
agreement.


         IN WITNESS WHEREOF, the parties hereto have executed this Series B
Convertible Preferred Stock Purchase Agreement as of the date first above
written.


                                       CORPORATION:

                                       NOVALON PHARMACEUTICAL
                                       CORPORATION


                                       By: [signature appears here]
                                           ----------------------------
                                           Name: Dana M. Fowlkes, M.D., Ph.D.
                                           Title: President & CEO


                                       INVESTOR:

                                       CUBIST PHARMACEUTICALS, INC.


                                       By: [signature appears here]
                                           ------------------------
                                           Scott M. Rocklage,
                                           President

                                       33



© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission