CUBIST PHARMACEUTICALS INC
SC 13D/A, 1999-11-23
PHARMACEUTICAL PREPARATIONS
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CUSIP No. 0002296781                       Page 1 of 4 Pages


                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                                 (Rule 13d-101)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
            TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                  RULE 13d-2(a)

                               (Amendment No. 2)1

                          Cubist Pharmaceuticals, Inc.
                                (Name of Issuer)

                          Common Stock, $.001 par value
                         (Title of Class of Securities)

                                   0002296781
                                 (CUSIP Number)

Jeremy L. Curnock Cook                       John C. MacMurray, Esq.
Rothschild Asset Management Ltd.             Reboul, MacMurray, Hewitt,
Five Arrows House                            Maynard & Kristol
St. Swithin's Lane                           45 Rockefeller Plaza
London EC4N 8NR England                      New York, New York  10111
Tel. 011-171-280-5000                        Tel. (212) 841-5700
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                               September 23, 1999
             (Date of Event Which Requires Filing of This Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule  because of Rule 13d- 1(e),  13d-1(f) or 13d-1(g),  check the following
box [ ].
- --------
       1  The  remainder  of this cover page shall be filled out for a reporting
person's  initial  filing on this  form with  respect  to the  subject  class of
securities,  and for any subsequent amendment containing information which would
alter  disclosures  provided in a prior cover page. The information  required on
the  remainder  of this cover  page  shall not be deemed to be  "filed"  for the
purpose  of  Section  18 of the  Securities  Exchange  Act of 1934 or  otherwise
subject to the  liabilities  of that  section of the Act but shall be subject to
all other provisions of the Act.

<PAGE>
CUSIP No. 0002296781                                          Page 2 of 4 Pages


1)   Name of Reporting Person                         International
     S.S. or I.R.S. Identification                    Biotechnology
     No. of Above Person                              Trust plc

2)   Check the Appropriate Box                               (a) [ ]
     if a Member of a Group                                  (b) [ ]

3)   SEC Use Only

4)   Source of Funds                                  Not Applicable


5)   Check if Disclosure of
     Legal Proceedings is                             Not Applicable
     Required Pursuant to
     Items 2(d) or 2(e)

6)   Citizenship or Place
     of Organization                                  United Kingdom

Number of                          7)  Sole Voting    1,199,661 shares of
Shares Beneficially                    Power          Common Stock, $.001
Owned by                                              par value ("Common
Reporting Person                                      Stock")

                                   8)  Shared Voting
                                       Power                 -0-

                                   9)  Sole Disposi-  1,199,661 shares of
                                       tive Power     Common Stock

                                   10) Shared Dis-
                                       positive Power        -0-


11)  Aggregate Amount Beneficially                    1,199,661 shares of
     Owned by Each Reporting Person                   Common Stock

12)  Check if the Aggregate
     Amount in Row (11)
     Excludes Certain Shares

13)  Percent of Class
     Represented by                                   5.9%
     Amount in Row (11)

14)  Type of Reporting
     Person                                           CO


<PAGE>
CUSIP No. 0002296781                                           Page 3 of 4 Pages

                         AMENDMENT NO. 2 TO SCHEDULE 13D

          Reference is hereby made to the  statement on Schedule 13D  originally
filed with the Securities and Exchange Commission (the "Commission") on July 28,
1997 and Amendment No. 1 thereto filed on November 30, 1998 (as so amended,  the
"Schedule  13D").  Terms  defined  in the  Schedule  13D are used  herein  as so
defined.

          The Schedule 13D is hereby amended as follows:

Item 5.  Interest in Securities of the Issuer.

          Item 5 is hereby  amended  and  restated  to read in its  entirety  as
follows:

          (a) Based on a total of 20,283,152  shares of Common Stock outstanding
as of November 12, 1999, as reported in the Issuer's Report on Form 10-Q for the
period ended  September 30, 1999 filed with the Commission on November 12, 1999,
IBT owns 1,199,661 shares of Common Stock, or  approximately  5.9% of the Common
Stock outstanding.

          (b) Except as described  in Item 6 of the  Schedule  13D, IBT has sole
power  to  vote  or  direct  the  voting  of and to  dispose  or to  direct  the
disposition of the shares of Common Stock referred to in paragraph (a) above.

          (c) Between  September 14 and September 24, 1999 IBT sold an aggregate
223,223 shares of Common Stock in open market transactions,  at an average price
of $10.30 per share.  On November 15, 1999 IBT exercised its Warrant for 111,112
shares of Common  Stock (the  "Warrant  Shares")  in its  entirety in a cashless
exercise transaction,  selling certain of the Warrant Shares to pay the exercise
price of $2.25 per share.  The remaining  83,334 Warrant Shares were then issued
to IBT.

          (d) No other  person has the power to direct the receipt of  dividends
on, or the proceeds from sales of, the shares of Common Stock owned by IBT.

          (e) Not applicable.

<PAGE>



CUSIP No. 0002296781                                           Page 4 of 4 Pages


                                    SIGNATURE


          After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information  set forth in this statement is true,  complete and
correct.

Dated: November 22, 1999

                                           INTERNATIONAL BIOTECHNOLOGY TRUST PLC


                                           By:/s/ Jeremy L. Curnock Cook
                                                      Director




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