ARRIS PHARMACEUTICAL CORP/DE/
DEF 14A, 1996-05-07
PHARMACEUTICAL PREPARATIONS
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<PAGE>
                            SCHEDULE 14A INFORMATION
 
Proxy Statement Pursuant to Section 14(a) of
the Securities Exchange Act of 1934 (Amendment No.    )
 
    Filed by the Registrant /X/
    Filed by a Party other than the Registrant / /
 
    Check the appropriate box:
    / /  Preliminary Proxy Statement
    / /  Confidential, for Use of the Commission Only (as permitted by Rule
         14a-6(e)(2))
    /X/  Definitive Proxy Statement
    / /  Definitive Additional Materials
    / /  Soliciting Material Pursuant to Section 240.14a-11(c) or Section
         240.14a-12
 
                              ARRIS PHARMACEUTICAL CORPORATION
- - --------------------------------------------------------------------------------
                (Name of Registrant as Specified In Its Charter)
 
- - --------------------------------------------------------------------------------
    (Name of Person(s) Filing Proxy Statement if other than the Registrant)
 
Payment of Filing Fee (Check the appropriate box)
 
/ /  $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1), or 14a-6(j)(2) or
     Item 22(a)(2) of Schedule 14A.
/ /  $500 per each party to the controversy pursuant to Exchange Act Rule
     14a-6(i)(3).
/ /  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.
     1. Title of each class of securities to which transaction applies:
        ------------------------------------------------------------------------
     2. Aggregate number of securities to which transaction applies:
        ------------------------------------------------------------------------
     3. Per unit price or other underlying value of transaction computed
        pursuant to Exchange Act Rule 0-11 (Set forth the amount on which the
        filing fee is calculated and state how it was determined):
        ------------------------------------------------------------------------
     4. Proposed maximum aggregate value of transaction:
        ------------------------------------------------------------------------
     5. Total fee paid:
        ------------------------------------------------------------------------
/X/  Fee paid previously with preliminary materials.
/ /  Check box if any part of the fee is offset as provided by Exchange Act Rule
     0-11(a)(2) and identify the filing for which the offsetting fee was paid
     previously. Identify the previous filing by registration statement number,
     or the Form or Schedule and the date of its filing.
     1. Amount Previously Paid:
        ------------------------------------------------------------------------
     2. Form, Schedule or Registration Statement No.:
        ------------------------------------------------------------------------
     3. Filing Party:
        ------------------------------------------------------------------------
     4. Date Filed:
        ------------------------------------------------------------------------
<PAGE>
                        ARRIS PHARMACEUTICAL CORPORATION
                      385 OYSTER POINT BOULEVARD, SUITE 3
                     SOUTH SAN FRANCISCO, CALIFORNIA 94080
                            ------------------------
 
                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON JUNE 5, 1996
                             ---------------------
 
TO THE STOCKHOLDERS OF ARRIS PHARMACEUTICAL CORPORATION:
 
    NOTICE  IS HEREBY  GIVEN that  the Annual  Meeting of  Stockholders of ARRIS
PHARMACEUTICAL CORPORATION, a Delaware corporation (the "Company"), will be held
on Wednesday,  June  5,  1996 at  8:00  a.m.  local time  at  385  Oyster  Point
Boulevard, Suite 3, South San Francisco, California for the following purposes:
 
    1.    To elect  directors  to serve  for the  ensuing  year and  until their
       successors are elected.
 
    2.  To approve the issuance of a sufficient number of shares to satisfy  the
       payment  of the  Second Stock Payment,  pursuant to  the Company's recent
       acquisition of Khepri Pharmaceuticals, Inc. ("Khepri").
 
    3.  To approve the issuance of a sufficient number of shares to satisfy  the
       exercise of certain exchange rights of the Class B Shareholders of Khepri
       Pharmaceuticals Canada, Inc.
 
    4.   To approve the  Company's 1989 Stock Plan,  as amended, to increase the
       aggregate number of shares of Common Stock authorized for issuance  under
       such plan by 550,000 shares, to 2,667,500 shares.
 
    5.   To approve the  Company's Employee Stock Purchase  Plan, as amended, to
       increase the number  of shares  of Common Stock  authorized for  issuance
       under such plan by 100,000 shares, to 250,000 shares.
 
    6.   To ratify the selection of Ernst & Young LLP as independent auditors of
       the Company for its fiscal year ending December 31, 1996.
 
    7.  To transact such other business as may properly come before the  meeting
       or any adjournment or postponement thereof.
 
    The  foregoing  items of  business  are more  fully  described in  the Proxy
Statement accompanying this Notice.
 
    The Board of Directors has fixed the close of business on April 15, 1996, as
the record date for the determination of stockholders entitled to notice of  and
to vote at this Annual Meeting and at any adjournment or postponement thereof.
 
                                          By Order of the Board of Directors
 
                                          Daniel H. Petree
                                          ASSISTANT SECRETARY
 
   
South San Francisco, California
May 8, 1996
    
 
 ALL  STOCKHOLDERS  ARE  CORDIALLY INVITED  TO  ATTEND THE  MEETING  IN PERSON.
 WHETHER OR NOT YOU EXPECT TO  ATTEND THE MEETING, PLEASE COMPLETE, DATE,  SIGN
 AND  RETURN THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE IN ORDER TO ENSURE YOUR
 REPRESENTATION AT THE MEETING. A RETURN ENVELOPE (WHICH IS POSTAGE PREPAID  IF
 MAILED  IN THE UNITED STATES)  IS ENCLOSED FOR THAT  PURPOSE. EVEN IF YOU HAVE
 GIVEN YOUR PROXY,  YOU MAY STILL  VOTE IN  PERSON IF YOU  ATTEND THE  MEETING.
 PLEASE NOTE, HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK
 OR OTHER NOMINEE AND YOU WISH TO VOTE AT THE MEETING, YOU MUST OBTAIN FROM THE
 RECORD HOLDER A PROXY ISSUED IN YOUR NAME.
<PAGE>
                        ARRIS PHARMACEUTICAL CORPORATION
                      385 OYSTER POINT BOULEVARD, SUITE 3
                     SOUTH SAN FRANCISCO, CALIFORNIA 94080
                            ------------------------
 
                                PROXY STATEMENT
                       FOR ANNUAL MEETING OF STOCKHOLDERS
                                  JUNE 5, 1996
                             ---------------------
 
                 INFORMATION CONCERNING SOLICITATION AND VOTING
 
GENERAL
 
   
    The enclosed proxy is solicited on behalf of the Board of Directors of Arris
Pharmaceutical  Corporation, a Delaware corporation  (the "Company"), for use at
the Annual Meeting  of Stockholders to  be held on  June 5, 1996,  at 8:00  a.m.
local  time  (the  "Annual  Meeting"), or  at  any  adjournment  or postponement
thereof, for the  purposes set forth  herein and in  the accompanying Notice  of
Annual  Meeting. The Annual Meeting will be  held at 385 Oyster Point Boulevard,
Suite 3, South San Francisco, California. The Company intends to mail this proxy
statement and  accompanying  proxy  card  on  or  about  May  8,  1996,  to  all
stockholders entitled to vote at the Annual Meeting.
    
 
SOLICITATION
 
    The  Company will bear the entire cost of solicitation of proxies, including
preparation, assembly, printing and mailing  of this proxy statement, the  proxy
and any additional information furnished to stockholders. Copies of solicitation
materials  will  be  furnished  to  banks,  brokerage  houses,  fiduciaries  and
custodians holding in their names shares  of Common Stock beneficially owned  by
others  to forward to such beneficial  owners. The Company may reimburse persons
representing beneficial owners  of Common  Stock for their  costs of  forwarding
solicitation  materials  to  such beneficial  owners.  Original  solicitation of
proxies  by  mail  may  be  supplemented  by  telephone,  telegram  or  personal
solicitation  by directors, officers  or other regular  employees of the Company
or, at  the  Company's  request,  First  Interstate  Bank,  N.A.  No  additional
compensation  will be paid to directors, officers or other regular employees for
such services, but First Interstate Bank,  N.A. will be paid its customary  fee,
estimated to be approximately $1,000, if it renders solicitation services.
 
VOTING RIGHTS AND OUTSTANDING SHARES
 
   
    Only holders of record of Common Stock at the close of business on April 15,
1996  will be entitled  to notice of and  to vote at the  Annual Meeting. At the
close of business on April 15, 1996 the Company had outstanding and entitled  to
vote 13,532,059 shares of Common Stock.
    
 
    Each  holder of record of Common Stock on  such date will be entitled to one
vote for each share held on all matters to be voted upon at the Annual Meeting.
 
    All votes will be tabulated by  the inspector of election appointed for  the
meeting,   who  will   separately  tabulate  affirmative   and  negative  votes,
abstentions and  broker  non-votes.  Abstentions will  be  counted  towards  the
tabulation  of votes  cast on proposals  presented to the  stockholders and will
have the same effect as negative  votes. Broker non-votes are counted towards  a
quorum,  but are not counted for any purpose in determining whether a matter has
been approved.
 
REVOCABILITY OF PROXIES
 
    Any person giving  a proxy pursuant  to this solicitation  has the power  to
revoke  it at any time before it is voted.  It may be revoked by filing with the
Secretary of the Company at the Company's principal executive office, 385 Oyster
Point Boulevard,  Suite 3,  South  San Francisco,  California 94080,  a  written
notice of revocation or a duly executed proxy bearing a later date, or it may be
revoked by attending the meeting and voting in person. Attendance at the meeting
will not, by itself, revoke a proxy.
<PAGE>
STOCKHOLDER PROPOSALS
 
   
    Proposals of stockholders that are intended to be presented at the Company's
1997  Annual Meeting of Stockholders  must be received by  the Company not later
than January 8, 1997 in  order to be included in  the proxy statement and  proxy
relating to that Annual Meeting.
    
 
                                   PROPOSAL 1
                             ELECTION OF DIRECTORS
 
    The  Board of Directors is  currently comprised of six  members. Each of the
nominees is currently a director of the Company and five were previously elected
by the stockholders at the 1995 Annual Meeting. One director, Vaughn M. Kailian,
was elected by the Board of  Directors on December 14, 1995, effective  December
22,  1995.  The  Board at  the  same  time increased  the  number  of authorized
directors to six. If elected, each of  the nominees would hold office until  the
next  annual meeting of stockholders and until  his successor is elected and has
qualified, or until such director's earlier death, resignation or removal.
 
    Shares represented by executed proxies will be voted, if authority to do  so
is  not withheld, for the election of the six nominees named below. In the event
that any nominee should be unavailable for election as a result of an unexpected
occurrence, such  shares will  be  voted for  the  election of  such  substitute
nominee as management may propose. Each person nominated for election has agreed
to  serve if elected  and management has  no reason to  believe that any nominee
will be unable to serve.
 
    Directors are  elected by  a plurality  of the  votes present  in person  or
represented by proxy and entitled to vote at the meeting.
 
    THE  BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE IN FAVOR OF EACH NAMED
NOMINEE.
 
NOMINEES
 
    The names of the nominees,  their ages as of  January 31, 1996, and  certain
information about them are set forth below:
 
<TABLE>
<CAPTION>
              NAME                   AGE                PRINCIPAL OCCUPATION/POSITION HELD WITH THE COMPANY
- - --------------------------------     ---     --------------------------------------------------------------------------
<S>                               <C>        <C>
John P. Walker                       47      President, Chief Executive Officer and Director
Michael J. Ross, Ph.D.               46      Executive Vice President, Chief Technical Officer and Director
Brook H. Byers                       50      Director
Anthony B. Evnin, Ph.D.              55      Director
Vaughn M. Kailian                    51      Director
Hans U. Sievertsson, Ph.D.           55      Director
</TABLE>
 
    JOHN P. WALKER has been President, Chief Executive officer and a Director of
the  Company since February 1993. From 1991 to 1993, he was a venture capitalist
at Alpha Venture Partners.  Prior to that time,  he was Chairman, President  and
Chief  Executive Officer of Vitaphore Corporation,  a company which was acquired
in April 1990 by  Union Carbide Chemicals and  Plastics Company, Inc.  Following
that  acquisition, Mr.  Walker served  as the  latter company's  Vice President,
Biomaterials Systems. From  1971 to 1985,  Mr. Walker was  employed by  American
Hospital  Supply  Corporation  in  variety  of  general  management,  sales  and
marketing positions, most recently serving as President of the American Hospital
Company. He received his B.A.  degree from the State  University of New York  at
Buffalo  and  conducted  graduate business  studies  at  Northwestern University
Institute for  Management. Mr.  Walker  serves as  director of  several  private
companies.
 
    MICHAEL  J.  ROSS,  PH.D.,  has  been  Executive  Vice  President  and Chief
Technical Officer of  the Company since  February 1993 and  a Director since  he
joined  the Company in September 1990  as President and Chief Executive Officer.
From   1978   to    1990,   he    was   employed   by    Genentech,   Inc.,    a
 
                                       2
<PAGE>
biopharmaceutical  company, where he most recently was Vice President, Medicinal
and Biomolecular Chemistry and was responsible for building that company's small
molecule discovery  effort. Dr.  Ross received  a Ph.D.  in chemistry  from  the
California  Institute  of  Technology  and  held  a  postdoctoral  fellowship in
molecular biology at Harvard University.
 
    BROOK H. BYERS, through  Kleiner Perkins Caufield &  Byers, was an  original
investor  in the Company  and has served as  a member of  the Board of Directors
since October 1990. Mr. Byers is a general partner of Kleiner Perkins Caufield &
Byers, a private venture capital firm which  he joined in 1977. He has been  the
founding  president  and chairman  of  four life  sciences  companies: Hybritech
Incorporated, IDEC Pharmaceuticals  Corporation, InSite Vision  Inc. and  Ligand
Pharmaceuticals  Incorporated. Mr. Byers currently serves  as a director of IDEC
Pharmaceuticals  Corporation,  InSite   Vision,  Inc.,  Ligand   Pharmaceuticals
Incorporated,  Athena Neurosciences, Inc. and Pharmacopeia.  He also serves as a
director of a number of privately-held  technology companies. Mr. Byers sits  on
the University of California, San Francisco Foundation Board of Directors.
 
    ANTHONY  B.  EVNIN,  PH.D.,  through  Venrock  Associates,  was  an original
investor in the Company  and has served  as a member of  the Board of  Directors
since  April 1989.  He is  a general  partner of  Venrock Associates,  a venture
capital firm that he joined in 1974. Dr. Evnin is a Director of Centocor,  Inc.,
Genetics  Institute, Inc., IDEXX Laboratories, Inc., Athena Neurosciences, Inc.,
Escalon Medical  Corp.,  Kopin Corporation,  Opta  Food Ingredients,  Inc.,  and
Sugen, Inc. He also serves as a director of several private companies.
 
    VAUGHN  M. KAILIAN has been  a director of the  Company since December 1995.
Mr. Kailian is  also President, Chief  Executive Officer and  a director of  COR
Therapeutics  and has served in  such capacities since March  1990. From 1967 to
1990 Mr.  Kailian was  employed by  Marion Merrell  Dow Inc.,  a  pharmaceutical
company,  and its predecessor companies in various general management, marketing
and sales  positions.  Most  recently,  Mr. Kailian  served  as  Corporate  Vice
President  of Global Commercial  Development, Marion Merrell  Dow, Inc. Prior to
that, Mr. Kailian  served as: President  and General Manager,  Merrell Dow  USA;
Vice  President,  Marketing  and Sales,  Merrell  Dow USA;  and  Vice President,
Marketing and Sales  of Merrell  Dow, Europe, Africa  and the  Middle East.  Mr.
Kailian also serves as a director of Amylin Pharmaceuticals, Inc.
 
    HANS  U. SIEVERTSSON, PROFESSOR,  PH.D., has been a  Director of the Company
since June 1993.  Dr. Sievertsson is  Executive Vice President  at Pharmacia  AB
(publ),  a pharmaceutical company and  an investor in Arris.  He is also a Board
member of the  Karolinska Institute and  a Board Member  of the Swedish  Medical
Research   Council.  Dr.  Sievertsson's   extensive  management  and  scientific
expertise includes  former  positions  as Senior  Vice  President  of  Research,
Development  and Environment,  Nobel Industries  Sweden AB  and as  President of
Nobel Kemi AB,  parent company of  the explosive and  chemical business area  of
Nobel  Industries  Sweden  AB.  Dr. Sievertsson  is  also  Professor  of Organic
Medicinal Chemistry at the University of Uppsala, Sweden.
 
BOARD COMMITTEES AND MEETINGS
 
    During the fiscal year ended December  31, 1995 the Board of Directors  held
five meetings. The Board has an Audit Committee, a Compensation Committee and an
Option Committee.
 
    The  Audit Committee meets with the  Company's independent auditors at least
annually to: review the  results of the annual  audit and discuss the  financial
statements;  recommend to the Board the independent auditors to be retained; and
receive and consider the accountants' comments as to internal controls, adequacy
of staff and management performance and procedures in connection with audit  and
financial  controls.  The  Audit  Committee  is  composed  of  two  non-employee
directors: Hans U. Sievertsson, Ph.D. and  Anthony B. Evnin, Ph.D. It met  twice
during the year ended December 31, 1995.
 
   
    The  Compensation  Committee makes  recommendations concerning  salaries and
incentive compensation, awards stock options to employees and consultants  under
the  Company's stock option  plans and otherwise  determines compensation levels
and performs such other functions regarding
    
 
                                       3
<PAGE>
compensation as the Board may  delegate. The Compensation Committee is  composed
of two non-employee directors: Brook H. Byers and Anthony B. Evnin. It met twice
during the year ended December 31, 1995.
 
    The  Option  Committee administers  the Company's  1989  Plan for  grants to
non-executive officer  employees.  The Option  Committee  has the  authority  to
approve the price and terms of such options, within the limits set by the Board.
In 1995, the Option Committee was composed of John P. Walker.
 
    During the year ended December 31, 1995, all directors attended at least 75%
of  the aggregate of  the meetings of the  Board and of  the committees on which
they served, held during the period for which they were a director or  committee
member, respectively.
 
                                   PROPOSAL 2
                 APPROVAL OF THE ISSUANCE OF ARRIS COMMON STOCK
                         TO FORMER KHEPRI SHAREHOLDERS
                    IN CONNECTION WITH ARRIS' ACQUISITION OF
                          KHEPRI PHARMACEUTICALS, INC.
 
BACKGROUND
 
    In  December 1995, Arris  acquired Khepri Pharmaceuticals,  Inc., a Delaware
corporation  located  in  South  San  Francisco,  California  ("Khepri")  in   a
stock-for-stock  merger (the "Merger"). In connection with this acquisition, the
Company issued 1,414,759 shares  of its Common Stock  to former shareholders  of
Khepri  (the "Initial Stock  Payment"). The acquisition  agreement also provided
that on December 30, 1996, at the election of the Company, the Company must make
either (i) an additional  issuance of shares to  certain former shareholders  of
Khepri,  subject to  the approval of  the Arris stockholders  (the "Second Stock
Payment"), or (ii) a cash payment (the "Cash Payment"), each as described below.
 
    The Company's  Common  Stock  trades  on the  Nasdaq  National  Market.  The
National  Association of Securities  Dealers ("NASD") rules  applicable to Arris
provide that Arris' stockholders must approve the issuance of Arris Common Stock
issued in connection with the transaction to the extent the number of shares  of
Arris  Common Stock to  be issued exceeds 20%  of the number  of shares of Arris
Common Stock outstanding prior to the Merger.
 
    Proposal 2  seeks the  approval, to  the extent  required by  the NASD  rule
described  above, for the issuance of shares of Arris Common Stock to the former
shareholders of Khepri sufficient to make the Second Stock Payment as  described
below.  It does not seek  approval of the Merger  itself, which has already been
completed.  The  Second  Stock  Payment   would  consist  of  the  issuance   of
approximately   518,700  shares  of  Arris  Common  Stock,  assuming  no  collar
adjustment (as described below). The Cash Payment would consist of a payment  by
Arris to former shareholders of Khepri of approximately $6,185,000. If the Arris
stockholders do not approve Proposal 2, the Company must make the Cash Payment.
 
    THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 2.
 
DESCRIPTION OF KHEPRI
 
    Khepri  was  incorporated in  Delaware in  August 1992  as a  privately held
corporation. Khepri was a development stage corporation focused on  accelerating
the  discovery and  development of cysteine  protease-based therapeutics. Khepri
had three  product  development programs:  a  protease for  asthma  and  chronic
obstructive  pulmonary  disease,  and  small  molecule  protease  inhibitors for
arthritis and for osteoporosis. For more information on the business of  Khepri,
see "Khepri -- Business" herein.
 
                                       4
<PAGE>
MATERIAL FEATURES OF THE MERGER
 
CONVERSION OF KHEPRI CAPITAL STOCK; ASSUMPTION OF KHEPRI OPTIONS.
 
    Pursuant to the Agreement and Plan of Reorganization and Merger, dated as of
November  7, 1995, by and among Arris,  Khepri, and a wholly-owned subsidiary of
Arris (the "Merger Agreement"), each share of capital stock of Khepri issued and
outstanding on December  22, 1995 was  converted into  a portion of  a share  of
Common  Stock  of Arris  on the  basis  of exchange  ratios described  below. In
addition, the former holders of Khepri  preferred stock will receive the  Second
Stock Payment or the Cash Payment, as described below.
 
   
    The  Initial Stock Payment was issued pursuant to an exemption under Section
3(a)(10) of the Securities Act of 1933,  as amended. A permit for the offer  and
sale  of such securities was issued by the California Department of Corporations
in December 1995,  following a fairness  hearing. The Second  Stock Payment,  if
effected, will be made pursuant to the same exemption.
    
 
   
    The  Merger was effected as a forward triangular merger. The Company created
a wholly-owned  subsidiary, Chapel  Acquisition Corp.,  a Delaware  corporation,
solely  for the purpose of effecting the  Merger. Upon completion of the Merger,
Khepri ceased  to  exist  and  the newly  created  subsidiary  survived  as  the
successor to all the assets and liabilities of Khepri. Subsequent to the closing
of the Merger, the subsidiary was renamed Arris Protease, Inc.
    
 
    COMMON STOCK; OPTIONS TO PURCHASE COMMON STOCK.  Each share of Khepri Common
Stock  was exchanged for 0.081484 of a  share of Arris Common Stock (the "Common
Exchange  Ratio")  on  December  22,  1995.  In  addition,  all  unexpired   and
unexercised  options to purchase Khepri  Common Stock outstanding under Khepri's
1993 Stock Option Plan were assumed  by Arris, and became exercisable for  Arris
Common  Stock, with  the number  of shares  and exercise  price adjusted  by the
Common Exchange Ratio.
 
    PREFERRED STOCK
 
    SERIES A PREFERRED  STOCK.  Each  share of Khepri  Series A Preferred  Stock
received  (1) 0.053434 of a share of Arris Common Stock (the "Series A Preferred
Exchange Ratio") on December 22, 1995 plus (2) the right to receive on  December
30,  1996, at Arris' option, either (x) .022259 of a share of Arris Common Stock
(the "Second Series A Stock Consideration"), adjusted as described below, or (y)
cash in an amount equal to $0.265438 (the "Series A Cash Consideration").
 
    SERIES B PREFERRED  STOCK.  Each  share of Khepri  Series B Preferred  Stock
received  (1) 0.106872 of a share of Arris Common Stock (the "Series B Preferred
Exchange Ratio") on December 22, 1995 plus (2) the right to receive on  December
30,  1996, at Arris' option, either (x) .044519 of a share of Arris Common Stock
(the "Second Series B Stock Consideration"), adjusted as described below, or (y)
cash in an amount equal to $0.530889 (the "Series B Cash Consideration").
 
    SERIES C PREFERRED  STOCK.  Each  share of Khepri  Series C Preferred  Stock
received  (1) .080169 of a share of  Arris Common Stock (the "Series C Preferred
Exchange Ratio") on December 22, 1995 plus (2) the right to receive on  December
30,  1996, at Arris' option, either (x) .033395 of a share of Arris Common Stock
(the "Second Series C Stock Consideration"), adjusted as described below, or (y)
cash in an amount equal to $0.39824 (the "Series C Cash Consideration").
 
    The  Second  Series  A  Stock  Consideration,  the  Second  Series  B  Stock
Consideration and the Second Series C Stock Consideration constitute the "Second
Stock Payment." The Series A Cash Consideration, the Series B Cash Consideration
and  the Series C  Cash Consideration constitute the  "Cash Payment." The Second
Stock Payment and  Cash Payment are  sometimes collectively referred  to as  the
"Second  Payment." If the Stockholders do  not approve the Second Stock Payment,
the Company  must make  the Cash  Payment. If  the Stockholders  do approve  the
Second  Stock Payment, Arris  will make a  determination in December  1996 as to
which payment method to elect.
 
                                       5
<PAGE>
    The aggregate number of shares of Arris Common Stock issuable to the holders
of Khepri Preferred Stock in the Second Stock Payment are subject to a  "collar"
adjustment  as follows: (1) in the event that the average closing price of Arris
Common Stock on the Nasdaq National Market (the "Average Closing Price")  during
the  ninety (90)  trading days  ending on December  27, 1996  (the "Arris Second
Payment Date Stock  Price") is  less than $10.13625  (which number  is equal  to
eighty-five  percent  (85%) of  the Average  Closing Price  for the  thirty (30)
trading days ending on November 6, 1995, or $11.925), the percentage of a  share
of  Arris  Common Stock  to be  received in  exchange for  each share  of Khepri
Preferred Stock will be increased by multiplying it by a fraction, the numerator
of which is $10.13625, and the denominator of which is the Arris Second  Payment
Date  Stock Price, or (2) in the event  that the Arris Second Payment Date Stock
Price is greater than  $13.71375 (which number is  equal to one hundred  fifteen
percent  (115%) of the Average Closing Price during the thirty (30) trading days
ending on November  6, 1995, or  $11.925), the  percentage of a  share of  Arris
Common Stock to be received in exchange for each share of Khepri Preferred Stock
will  be decreased by  multiplying it by  a fraction, the  numerator of which is
$13.71375, and the denominator of which  is the Arris Second Payment Date  Stock
Price.
 
   
    The  purchase price  of the  Company's Common Stock  that will  be issued to
former stockholders of Khepri is set forth in the Merger Agreement. The purchase
price was determined at the time  of execution of the Merger Agreement,  subject
to  the collar adjustment  described below, by  arm's-length negotiations by the
Board of Directors  of the Company  following negotiations with  Khepri and  its
stockholders, with the advice of management and the Company's advisors.
    
 
    The  following table shows the approximate  number of shares of Arris Common
Stock that will be issued to the  former holders of Khepri Preferred Stock at  a
range  of possible Arris Common  Stock prices during the  90 trading days ending
December 27, 1996.
 
<TABLE>
<CAPTION>
                      APPROXIMATE NUMBER OF SHARES
                       ISSUABLE TO FORMER HOLDERS
ARRIS SECOND PAYMENT               OF
  DATE STOCK PRICE       KHEPRI PREFERRED STOCK
- - --------------------  ----------------------------
<S>                   <C>
       $10.00                   525,800
       $12.00                   518,700
       $14.00                   508,100
       $16.00                   444,600
</TABLE>
 
    RESTRICTIONS ON  TRANSFERABILITY FOR  KHEPRI STOCKHOLDERS.   All  shares  of
Arris  Common Stock issued in the Merger on  December 22, 1995 to the holders of
Khepri Preferred Stock and three  executive officers of Khepri (the  "Designated
Stockholders")  are subject to  certain restrictions as set  forth in the Merger
Agreement. The Designated Stockholders have each executed and delivered to Arris
a  Stockholder  Agreement,  which  includes  an  agreement  by  such  Designated
Stockholders  to  abide by  the transfer  restrictions  contained in  the Merger
Agreement. Pursuant  to such  restrictions,  which were  negotiated in  part  to
provide assurance that the Merger would be treated as a tax-free reorganization,
Designated  Stockholders who held Khepri Preferred Stock have agreed not to sell
or transfer an aggregate of 1,000,000 of  the shares of Arris Common Stock  they
received  at closing of the Merger  (except for permitted pro rata distributions
by partnerships) until after January  1, 1997. Designated Stockholders who  held
Khepri  Common Stock have similarly agreed not  to sell or transfer an aggregate
of approximately 41,000 of the shares of Arris Common Stock they received at the
closing of the Merger.  The Designated Stockholders have  further agreed not  to
sell or transfer the remainder of the shares they received at the closing of the
Merger  prior to  June 20,  1996, as required  in connection  with the Company's
March 1996 public offering.
 
    TAX AND ACCOUNTING  TREATMENT.   The exchange  of Khepri  capital stock  for
Arris  Common Stock in  the Merger is  intended to be  a tax-free reorganization
within the  meaning  of Section  368(a)  of the  Code  and accounted  for  as  a
"purchase" for accounting purposes.
 
                                       6
<PAGE>
    DISSENTERS'  RIGHTS.    Shareholders  of  Khepri  were  entitled  to certain
dissenters' rights under applicable state  law. No shareholder chose to  perfect
such rights at the time the Merger was consummated.
 
GENERAL EFFECT UPON THE RIGHTS OF EXISTING STOCKHOLDERS
 
   
    The  Merger did not change the rights of the existing stockholders of Arris;
however, the  Merger did  dilute Arris  stockholders' equity  interest in  Arris
because  of  the increase  in  the number  of shares  of  Common Stock  of Arris
outstanding and subject to options. As  of April 15, 1996, 13,532,059 shares  of
Common  Stock were  issued and  outstanding, no  shares of  Preferred Stock were
issued and  outstanding,  1,598,191  shares  of Common  Stock  were  subject  to
issuance  upon the exercise of outstanding  vested and unvested options, 275,214
shares of Common Stock were issuable  upon the exercise of outstanding  warrants
and  161,418  shares of  Common Stock  were  issuable upon  outstanding exchange
rights (see Proposal 3). The Second Stock Payment would consist of the  issuance
of  approximately  518,700  shares of  Arris  Common Stock,  assuming  no collar
adjustment. The Cash Payment would consist of  a payment by Arris to the  former
shareholders   of  Khepri  of  approximately  $6,185,000.  Pursuant  to  Section
6(i)(1)(c)(ii) of Part III of Schedule  D to the NASD By-Laws, the  stockholders
of  Arris are required, by vote of a majority of the shares represented by proxy
or in person  at the  Annual Meeting,  to approve  any issuance  of stock  which
constituted an amount equal to more than twenty percent (20%) of the outstanding
capital  stock of Arris at the time of the Merger. Arris may not make the Second
Stock Payment  to  the holders  of  Khepri  Preferred Stock  without  the  prior
authorization of the stockholders of Arris. At Arris' election, or if the Second
Stock Payment is not authorized by Arris' stockholders, Arris will make the Cash
Payment.
    
 
REASON FOR THE RECOMMENDATION OF THE BOARD OF DIRECTORS
 
    The  Board of Directors recommends a vote in favor of Proposal 2 in order to
give the Company the flexibility to make the Second Payment in the manner  which
is  in the  best interests  of the  Company. Historically,  the share  prices of
biotechnology companies have been extremely volatile. Development of  commercial
products, even with collaborative agreements in place, requires significant cash
resources. The Board of Directors therefore currently intends to make the Second
Stock  Payment, if the stockholders approve this  Proposal 2, but the Board will
retain the right to make the Cash  Payment should the Board decide that this  is
in the best interests of the stockholders.
 
   
ADVANTAGES AND DISADVANTAGES OF PROPOSAL 2
    
 
   
    The  principal advantage  of Proposal  2 to  the Arris  stockholders is that
approval would  provide the  Board of  Directors with  the ability  to make  the
Second  Payment in either cash  or Common Stock. In  approving the proposal, the
stockholders will provide the Board with the flexibility to determine which form
of payment would be in  the best interests of  the Company and its  stockholders
when payment becomes due. As noted above, the Company expects the development of
its  proposed  products  and  programs to  require  significant  additional cash
resources. Therefore, providing  the Board  with the flexibility  to effect  the
Second  Payment in  stock rather than  cash may  be of significant  value to the
stockholders by allowing  the Company  to retain  its cash  resources for  other
uses,  if appropriate. A further advantage  relates to timing considerations. By
approving Proposal 2, the  Arris stockholders will allow  the Board to make  its
determination  at  the time  the Second  Payment  is due  rather than  months in
advance of the due date. The collar adjustment, if any, cannot now be determined
because it will be based on the price of the Common Stock during the 90  trading
days ending on December 27, 1996. The Board will therefore have more information
available  at  the time  payment is  due and  will be  able to  incorporate such
information in its determination.
    
 
   
    If Proposal 2  is not  approved by the  stockholders, the  Company would  be
required  to effect the Second Payment  with cash. Therefore, stockholders would
not be  subject  to additional  dilution  as a  result  of the  stock  issuance.
However, payment in cash may not be in the best interests of the Company and its
stockholders  at the time payment is due. Accordingly, the Company believes that
approval of Proposal  2, which leaves  this decision to  the Board of  Directors
based  upon facts as they come to exist in December, is in the best interests of
the Company and its stockholders.
    
 
                                       7
<PAGE>
OTHER MATERIAL TERMS OF MERGER AGREEMENT
 
   
    REPRESENTATIONS AND  WARRANTIES.    The Merger  Agreement  contains  certain
representations  and warranties made by  Arris and Khepri as  of the date of the
Merger Agreement.  Each party's  representations  and warranties  are  primarily
concerned with various aspects of such party's business, including its corporate
powers,   assets,  liabilities,   intellectual  and   other  properties,  recent
operations, and financial condition. All representations and warranties made  by
Khepri will terminate on March 31, 1997. All representations and warranties made
by  Arris terminated as of December 22, 1995, except for certain representations
and warranties with respect to the corporate organization and capitalization  of
Arris,  the  authority and  legal  ability of  Arris  to enter  into  the Merger
Agreement and consummate the Merger, the issuance of Arris Common Stock pursuant
to the merger and Arris' lack of any obligation to pay finders' or similar  fees
except to a certain financial advisor, which representations and warranties will
terminate on March 31, 1997.
    
 
   
    INDEMNIFICATION.   Under  the terms of  the Merger Agreement,  Arris will be
indemnified for any costs, losses, liabilities, damages, lawsuits, deficiencies,
claims and expenses incurred in connection with, arising out of, resulting  from
or  relating  to  (i) any  inaccuracy  in  or breach  of  any  representation or
warranty, or (ii)  any breach of  any covenant  or obligation of  Khepri in  any
material respect, or (iii) any failure by Khepri to pay any tax required to have
been paid on or prior to the closing of the Merger, or (iv) any legal proceeding
relating to (i)-(iii) above. Claims with respect to such indemnification must be
made  by the indemnified  parties prior to  March 31, 1997,  although payment or
other resolution  of  claims  made  within such  period  may  take  longer.  The
indemnification  is payable by the holders of Khepri Preferred Stock entitled to
receive  the   Second   Payment  on   a   pro-rata  basis   (the   "Indemnifying
Stockholders").  Under the terms of the  Merger Agreement, the maximum liability
of each Indemnifying  Stockholder is equal  to the following  percentage of  the
total  consideration payable  to such  Indemnifying Stockholder  pursuant to the
Merger: (i) twenty percent (20%) up to and including June 22, 1996; (ii) fifteen
percent (15%) from  June 23,  1996 until December  31, 1996,  together with  any
claims  made during the  period specified in  (i) above (subject  to the maximum
specified in  (i)); (iii)  seven  and one-half  percent  (7.5%) from  and  after
January  1, 1997 up to and including  March 31, 1997, plus any claims previously
made (subject to the maximums  set forth in (i) and  (ii) above); and (iv)  zero
percent  (0%) after March 31, 1997, plus  any claims previously made (subject to
the maximums  set  forth in  (i),  (ii) and  (iii)  above). Subject  to  certain
procedures  set  forth in  the Merger  Agreement, Arris  first must  satisfy any
liability of  the Indemnifying  Stockholders for  indemnification by  offsetting
such  liability against the amounts payable  to the Indemnifying Stockholders in
the Second Payment. The Indemnifying Stockholders  will not be required to  make
any  indemnification  payment  until  the  total  amount  of  damages  for which
indemnification is applicable exceeds  $100,000 in the  aggregate, and then  are
only  required to pay  for the portion  of such damages  which exceeds $100,000.
Certain provisions have been made for purposes of resolving disputed claims  and
the  like. By approving the terms of the Merger, Khepri's stockholders appointed
A. Grant Heidrich as  Stockholders' Representative with  authority and power  to
act  on behalf of the stockholders with respect to indemnification issues and in
certain other matters in connection with the Merger Agreement.
    
 
INTEREST OF CERTAIN PARTIES
 
    Brook Byers, a  member of  the Board  of Directors  of Arris,  is a  general
partner   of  Kleiner  Perkins  Caufield  &  Byers,  which,  together  with  its
affiliates, owned approximately 17.2% of the outstanding capital stock of Khepri
prior to the Merger. Kleiner Perkins  Caufield & Byers and its affiliates  would
receive  92,662  shares  of Arris  Common  Stock  in the  Second  Stock Payment,
assuming no  collar adjustment,  or $1,154,740  if the  Company makes  the  Cash
Payment.  Mr. Byers did not participate in  the negotiation of the Merger or the
Arris Board of  Directors' consideration  or approval  of the  Merger. No  other
officer, director or principal stockholder of Arris had any material interest in
the  Merger, other than an interest  arising solely from ownership of securities
of Arris.
 
    Arris has entered into transition service agreements with each of Donald  G.
Payan,  M.D., David  A. Estell, Ph.D,  and N.  Jean Warner, M.D.,  each a former
executive officer of Khepri, pursuant to which
 
                                       8
<PAGE>
such persons became Vice  Presidents of Arris upon  consummation of the  Merger.
Such  transition services agreements provide that  such persons (i) continued to
receive their  then-current salaries,  subject to  a percentage  increase  which
occurred on January 1, 1996 determined by the Arris compensation committee to be
awarded  to employees  rated as  outstanding on such  date, (ii)  were granted a
signing bonus in the amount  of $10,000 in the cases  of Drs. Payan and  Estell,
and an option to purchase 10,000 shares of Arris Common Stock in accordance with
Arris'  company policies in the case of  Drs. Warner and Estell, (iii) receive a
one-time lump sum bonus of fifty percent (50%) of their respective base salaries
on December 22, 1996  if still employed  by Arris on such  date, and (iv)  shall
receive  as severance if terminated by Arris without cause prior to December 22,
1996, twelve months salary and continued vesting of their stock options for  two
years.
 
    Pursuant  to  the  Merger Agreement,  each  of  Arris and  Khepri  adopted a
severance plan  which  provides for  severance  payments  to be  paid  to  their
employees  if such employees are terminated in  connection with the Merger on or
before June 22, 1996. Such severance  arrangement consists of a cash payment  of
either  three, six or  twelve months base  salary, depending upon  the nature of
such employee's position with Arris or Khepri, as the case may be (together with
payment  of  such   employee's  medical  coverage   during  such  period),   and
acceleration  of vesting of such employee's stock options for the period of such
employee's severance period plus one year.
 
                                       9
<PAGE>
                      SELECTED CONSOLIDATED FINANCIAL DATA
 
                        ARRIS PHARMACEUTICAL CORPORATION
 
    The selected consolidated financial data set forth below with respect to the
statements of  operations  for each  of  the three  years  in the  period  ended
December  31, 1995 and balance sheets at December 31, 1994 and 1995, are derived
from financial statements of Arris that have been audited by Ernst & Young  LLP,
independent  auditors. These financial statements are not included in this Proxy
Statement  but  are  incorporated  by  reference  from  the  audited   financial
statements  in Arris' Annual Report on Form 10-K for the year ended December 31,
1995,  which  financial  statements  are  included  in  the  Annual  Report   to
Stockholders  being mailed to  stockholders together with  this Proxy Statement.
The statement of operations data for the years ended December 31, 1991 and  1992
and  the balance sheet  data as of December  31, 1992 and  1993 are also derived
from financial statements audited by Ernst & Young LLP but not included in  this
Proxy  Statement.  The data  should be  read in  conjunction with  the financial
statements  and  related  notes  incorporated  by  reference  and  "Management's
Discussion  and Analysis of Financial Condition and Results of Operations" which
is also included in the Annual Report to Stockholders.
<TABLE>
<CAPTION>
                                                                      YEARS ENDED DECEMBER 31,
                                                      ---------------------------------------------------------
                                                        1991        1992        1993        1994      1995 (1)
                                                      ---------  ----------  ----------  ----------  ----------
                                                              (IN THOUSANDS, EXCEPT PER SHARE AMOUNTS)
<S>                                                   <C>        <C>         <C>         <C>         <C>
CONSOLIDATED STATEMENTS OF OPERATIONS:
Contract revenues...................................  $      25  $       --  $    2,542  $    8,304  $   16,727
Operating expenses
  Research and development..........................      4,833       6,994       8,910      13,155      14,689
  General and administrative........................        869       1,531       2,283       4,010       4,247
  Acquired in-process research and development......         --          --          --          --      22,514
                                                      ---------  ----------  ----------  ----------  ----------
    Total operating expenses........................      5,702       8,525      11,193      17,165      41,450
                                                      ---------  ----------  ----------  ----------  ----------
Operating loss......................................     (5,677)     (8,525)     (8,651)     (8,861)    (24,723)
Interest income (expense), net......................         49         (68)        172         522         990
                                                      ---------  ----------  ----------  ----------  ----------
Net loss............................................  $  (5,628) $   (8,593) $   (8,479) $   (8,339) $  (23,733)
                                                      ---------  ----------  ----------  ----------  ----------
                                                      ---------  ----------  ----------  ----------  ----------
Net loss per share..................................  $   (1.44) $    (2.15) $    (2.10) $    (0.97) $    (2.71)
Weighted average number of shares outstanding.......      3,904       4,006       4,031       8,570       8,745
 
<CAPTION>
 
                                                                            DECEMBER 31,
                                                      ---------------------------------------------------------
                                                        1991        1992        1993        1994      1995 (2)
                                                      ---------  ----------  ----------  ----------  ----------
                                                                           (IN THOUSANDS)
<S>                                                   <C>        <C>         <C>         <C>         <C>
CONSOLIDATED BALANCE SHEET DATA:
Cash, cash equivalents and marketable investments...  $   2,518  $    8,422  $   25,610  $   30,070  $   31,105
Total assets........................................      4,949      11,934      31,063      34,786      40,293
Long-term obligations...............................     11,860      26,429       3,352       7,645      16,490
Accumulated deficit.................................     (7,732)    (16,325)    (24,804)    (33,298)    (56,876)
Total stockholders' equity..........................     (7,698)    (16,288)     21,654      13,425       7,278
</TABLE>
 
- - ------------------------
(1) Includes the results of operations of Khepri from December 22, 1995  through
    December  31,  1995, including  a  one-time charge  for  acquired in-process
    research and development. Excluding such one  time charge, net loss and  net
    loss per share would have been $1,219,000 and $0.14 per share, respectively.
    With the acquisition of Khepri, the Company expects net loss from continuing
    operations to increase significantly.
 
(2) Includes the acquisition of Khepri as of December 22, 1995.
 
                                       10
<PAGE>
                            SELECTED FINANCIAL DATA
 
                          KHEPRI PHARMACEUTICALS, INC.
 
    The  selected financial data set forth  below with respect to the statements
of operations for  the period from  inception (April 24,  1992) to December  31,
1992  and the years ended December 31, 1993 and 1994, are derived from financial
statements of  Khepri  that  have been  audited  by  Ernst &  Young  LLP.  These
financial   statements  are  not  included  in  this  Proxy  Statement  but  are
incorporated by reference from the Current Report on Form 8-K filed by Arris  on
January  5, 1996, as amended on February 5, 1996 and the selected financial data
set forth below with respect to Khepri is qualified in its entirety by reference
to such financial statements and notes thereto. The statement of operations data
for the period  ending December  22, 1995  is derived  from unaudited  financial
statements  not  included  in  this  Proxy  Statement.  The  unaudited financial
statements  include  all  adjustments,  consisting  only  of  normal   recurring
adjustments  and accruals  that Arris and  Khepri consider necessary  for a fair
presentation of  the financial  positions and  results of  operations for  these
periods.
 
<TABLE>
<CAPTION>
                                                           PERIOD FROM      YEAR ENDED DECEMBER      PERIOD FROM
                                                        INCEPTION (APRIL            31,             JANUARY 1 TO
                                                          24, 1992) TO      --------------------  DECEMBER 22, 1995
                                                        DECEMBER 31, 1992     1993       1994        (UNAUDITED)
                                                       -------------------  ---------  ---------  -----------------
<S>                                                    <C>                  <C>        <C>        <C>
Revenues.............................................       $      --       $      --  $      --      $     727
Operating expenses:
  Research and development...........................             544           3,596      6,991          6,600
  General and administrative.........................             137           1,030      1,497          1,983
                                                               ------       ---------  ---------        -------
Loss from operations.................................            (681)         (4,626)    (8,488)        (7,856)
Interest income (net)................................               5             113          8            166
Loss from subsidiary.................................              --              --         --           (322)
                                                               ------       ---------  ---------        -------
Net loss.............................................       $    (676)      $  (4,513) $  (8,480)     $   8,012
                                                               ------       ---------  ---------        -------
                                                               ------       ---------  ---------        -------
Net loss per share...................................                                                 $    (.45)
Weighted average number of shares outstanding (1)....                                                    17,609
</TABLE>
 
- - ------------------------
(1) Weighted  average  number of  shares outstanding  includes Common  Stock and
    Preferred Stock, on an as-if-converted basis.
 
                                       11
<PAGE>
                               PRO FORMA COMBINED
 
    The following table sets forth the unaudited combined pro forma statement of
operations for the year ended  December 31, 1995 as  if the operations of  Arris
and  Khepri had  been combined  as of  January 1,  1995. The  pro forma combined
statement of operations includes the consolidated financial results of Arris for
the twelve months ended December 31, 1995 (which consolidates the results of the
acquired operation for the  nine-day period from  date of acquisition,  December
22,  1995, to December 31, 1995) and Khepri  for the period from January 1, 1995
through the date of  the Merger. All  operations of Khepri  were closed for  the
nine-day  period from  the acquisition date  to December 31,  1995. The combined
results are not  necessarily indicative of  the actual results  that would  have
occurred  had the acquisition been consummated January 1, 1995, or of the future
operations of the combined entities.
 
<TABLE>
<CAPTION>
                                                            KHEPRI
                                                         PERIOD FROM
                                                          JANUARY 1,                    PRO FORMA
                                             ARRIS       1995 THROUGH                    COMBINED
                                           YEAR ENDED    ACQUISITION                    YEAR ENDED
                                          DECEMBER 31,   DECEMBER 22,    PRO FORMA     DECEMBER 31,
                                              1995           1995       ADJUSTMENTS        1995
                                          ------------   ------------   ------------   ------------
                                                  (IN THOUSANDS, EXCEPT PER SHARE AMOUNTS)
<S>                                       <C>            <C>            <C>            <C>
Contract revenues.......................    $ 16,727       $    727       $     --       $ 17,454
Operating expenses:
  Research and development..............      14,689          6,600            645(1)      22,079
                                                                               145(2)
  General and administrative............       4,247          1,983             30(2)       6,260
  Acquired in-process research and
   development..........................      22,514             --        (22,514)(3)         --
                                          ------------   ------------   ------------   ------------
    Total operating expenses............      41,450          8,583        (21,694)        28,339
                                          ------------   ------------   ------------   ------------
Operating loss..........................     (24,723)        (7,856)        21,694        (10,885)
Interest income, net....................         990            166             --          1,156
Loss from subsidiary....................          --           (322)           322(1)          --
                                          ------------   ------------   ------------   ------------
Net loss................................    $(23,733)      $ (8,593)      $ 22,016       $ (9,729)
                                          ------------   ------------   ------------   ------------
                                          ------------   ------------   ------------   ------------
Net loss per share......................                                                 $  (0.96)(4)
Weighted average number of shares
 outstanding............................                                                   10,124
</TABLE>
 
- - ------------------------
(1) Adjustment to consolidate Khepri Canada operations into Arris operations and
    reverse Khepri's recognition  of Khepri  Canada expense  recorded under  the
    equity method of accounting.
 
(2) Adjustment  reflects  one year  of amortization  of  acquired work  force in
    place, with a total fair value of $525,000, which is being amortized over  a
    three year life.
 
(3) Adjustment  to reverse write-off of  acquired research and development. This
    amount is  reflected  as an  expense  in Arris'  Consolidated  Statement  of
    Operations  for  the  year  ended  December  31,  1995  and  in  the  Arris'
    Consolidated Balance Sheet at December 31,  1995. It is eliminated from  the
    pro  forma  statements  of  operations since  it  is  a  nonrecurring charge
    directly attributable to the acquisition.
 
(4) The pro  forma combined  net loss  per share  and shares  used in  computing
    amounts  for the year ended December  31, 1995 have been calculated assuming
    that the acquisition occurred on January 1, 1995. Accordingly, the 1,415,000
    shares issued on December 22, 1995  in the acquisition have been treated  as
    outstanding since January 1, 1995.
 
                                       12
<PAGE>
INFORMATION WITH RESPECT TO ARRIS
 
    Arris  Annual Report on  Form 10-K for  the year ended  December 31, 1995 as
filed with  the  Securities  and  Exchange Commission  on  March  14,  1996,  is
incorporated by reference herein. Certain Sections of the Form 10-K are included
in  the 1995 Annual Report to Stockholders which is being mailed to stockholders
concurrently with this Proxy Statement.
 
DESCRIPTION OF ARRIS CAPITAL STOCK
 
    The description of Arris capital stock is incorporated by reference from the
Company's Registration Statement on Form 8-A  (File No. 0-22788), as filed  with
the Securities and Exchange Commission on November 4, 1993.
 
KHEPRI -- BUSINESS
 
    Khepri  was incorporated in the State of  Delaware in August 1992, and was a
privately held corporation at the time  of the Merger. Khepri was a  development
stage  corporation focused on accelerating the  discovery and development of the
next-generation of protease-based therapeutics. Khepri's technology was directed
exclusively on  those regulatory  proteases and  their inhibitors  that  provide
potential  therapeutic utility. Khepri's goal  was to develop novel therapeutics
that intervene at key control points in disease processes with an approach  that
combines  biology  and chemistry  to create  new tools  for rapid  lead compound
development. At the  time of the  Merger, Khepri had  three product  development
programs:  a  protease (aerosolized  rNEP)  for asthma  and  chronic obstructive
pulmonary disease, and small molecule protease inhibitors for arthritis and  for
osteoporosis.
 
    Khepri  built a technology platform with emphasis on protease genomics, gene
expression, chemistry, biology and  drug design. These  capabilities led to  the
identification  of  proteases that  may be  important disease  targets. Khepri's
protease  technology   provides   new   opportunities  in   the   discovery   of
protease-based therapeutics for various diseases, including infectious diseases,
organ transplant rejection, cancer and tissue ischemia.
 
    In  the  field  of  regulatory  proteases  and  their  inhibitors,  Khepri's
strategic focus was based on the following capabilities and tools:
 
    - PROTEASE GENOMICS: The ability to rapidly identify and analyze new  genes,
      their associated proteins, and to determine their pharmaceutical relevance
      is  a  critical step  in drug  discovery. Using  a variety  of techniques,
      Khepri had, within  the last  year, isolated and  characterized nine  full
      length  protease genes. Khepri believed  that its capabilities in protease
      expression, inhibitor  design and  protease biology  would facilitate  the
      accelerated  determination of  the biological  and medical  importance and
      potential therapeutic utility of these and other novel genes.
 
    - PROTEASE EXPRESSION: Khepri researchers have developed multiple expression
      systems that can be used to express large amounts of human proteases. This
      capability accelerates target characterization and inhibitor design.
 
    - PROTEASE INHIBITOR DESIGN: Khepri's proprietary chemistries and experience
      relevant to  structure/function  relationships  in  proteases  may  permit
      inhibitor  design for  specific target  proteases. Khepri  scientists have
      designed inhibitors which are  orally bioavailable, chemically stable  and
      are  unreactive in the absence of specific targeted proteases. In addition
      to  this  drug  design  approach,  Khepri  has  augmented  its   discovery
      capabilities   by  implementing   a  "targeted"   combinatorial  chemistry
      approach. Khepri believed  that these  tools reduce the  time required  to
      produce a new lead compound.
 
    - PROTEASE  BIOLOGY: Khepri has  developed proprietary IN  VIVO and IN VITRO
      techniques for  determining  the  therapeutic  utility  of  proteases  and
      specific  inhibitors  against  novel  targets.  In  addition,  Khepri  has
      technology  to  identify  the  biological  substrate(s)  for  a   specific
      protease.  Khepri scientists  also have developed  techniques for labeling
      the particular  protease  involved in  a  given biological  process.  This
      technology  allows Khepri to identify  regulatory proteases and inhibitors
      that are involved in disease processes.
 
                                       13
<PAGE>
    In March 1995,  Khepri formed Khepri  Pharmaceuticals Canada, Inc.  ("Khepri
Canada"), a subsidiary incorporated under the laws of Quebec, Canada and located
in  Montreal. Fifty  percent (50%)  of the  outstanding capital  stock of Khepri
Canada is owned  by Khepri, and  the remaining  fifty percent (50%)  is held  in
equal amounts by two Canadian investors.
 
    At the time of the Merger, Khepri had 44 employees, 36 of whom were directly
involved  in research and development. Khepri's principal executive offices were
located at 260 Littlefield Avenue,  South San Francisco, California, 94080,  and
its telephone number was (415) 794-3500.
 
PROPERTIES
 
    At  the time of the Merger, Khepri occupied approximately 32,000 square feet
of office and laboratory space in South San Francisco, California. Arris is  now
occupying this space as an expansion of its corporate facilities.
 
LEGAL PROCEEDINGS
 
    At  the time  of the Merger,  Khepri was not  a party to  any material legal
proceedings.
 
FINANCIAL INFORMATION
 
    Prior to the  Merger, the Common  Stock of Khepri  was not publicly  traded.
Khepri  did not, from its inception until  December 22, 1995, declare or pay any
dividends on its Common Stock.
 
    Financial statements of  Khepri for the  years ended December  31, 1994  and
December  31, 1993, which were  audited by Ernst &  Young LLP, and the unaudited
pro forma combined financial statements, which include the financial  operations
of  Khepri for the period from January  1 to December 22, 1995, are incorporated
by reference from the Current  Report on Form 8-K filed  by Arris on January  5,
1996, as amended on February 5, 1996.
 
STATEMENTS OF OPERATIONS
 
<TABLE>
<CAPTION>
                                                          FROM JANUARY 1,
                                                               1995
                                                          TO THE DATE OF
                                                            ACQUISITION         YEAR ENDED         YEAR ENDED
                                                        (DECEMBER 22, 1995)  DECEMBER 31, 1994  DECEMBER 31, 1993
                                                        -------------------  -----------------  -----------------
                                                                                ($000'S)
<S>                                                     <C>                  <C>                <C>
Revenues..............................................      $       727          $      --          $      --
Operating expenses:
  Research and development............................            6,600              6,991              3,596
  General and administrative..........................            1,983              1,497              1,030
                                                                -------            -------            -------
    Total operating expenses..........................            8,583              8,488              4,626
                                                                -------            -------            -------
Operating loss........................................           (7,856)            (8,488)            (4,626)
Interest income, net..................................              166                  8                113
Loss from subsidiary..................................             (322)                --                 --
                                                                -------            -------            -------
Net Loss..............................................      $    (8,012)         $  (8,480)         $  (4,513)
                                                                -------            -------            -------
                                                                -------            -------            -------
</TABLE>
 
MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF
OPERATIONS
 
    In  December 1995,  Arris acquired Khepri  in a  stock-for-stock merger. The
following discussion relates to the historical operations of Khepri prior to the
completion of the Merger. As  a result of the  Merger, the operations of  Khepri
have been substantially restructured. Therefore, the information set forth below
may  not be indicative of future operating results of Khepri or Khepri and Arris
combined.  See  the  information  appearing  under  the  heading   "Management's
Discussion  and Analysis of Financial Condition and Results of Operations" which
is included in the  Annual Report to Stockholders  being mailed to  stockholders
concurrently with this Proxy Statement and is incorporated by reference herein.
 
                                       14
<PAGE>
RESULTS OF OPERATIONS
 
PERIOD FROM JANUARY 1 TO DECEMBER 22, 1995 AND YEAR ENDED DECEMBER 31, 1994
 
    Khepri  reported revenues  of $727,000  in 1995  from evaluation  studies by
potential collaboration  partners,  federal research  grants,  and the  sale  of
scientific  compounds to its Canadian subsidiary. Khepri had no revenues in 1993
and 1994.
 
    Research  and  development  costs  decreased  to  $6,600,000  in  1995  from
$6,991,000 in 1994 due to a reduction in the use of outside services, scientific
and general supplies, and travel.
 
    General  and  administrative  costs  increased to  $1,983,000  in  1995 from
$1,497,000 in 1994 mainly  due to an increase  in professional and banking  fees
related to the acquisition of Khepri by Arris and additional personnel expenses,
due to the addition of a chief financial officer.
 
    Net interest income increased to $166,000 in 1995 from $8,000 in 1994 mainly
due  to  higher  interest income  as  a result  of  high average  cash  and cash
equivalent balances in  1995 from the  closing of approximately  $11 million  of
equity  financing in November  1994. Interest expense  in 1995 was approximately
equal to interest expense in 1994.
 
    Khepri recorded a loss  of $322,000 under the  equity method of  accounting,
representing  its  share in  the  operating results  of  its 50%  owned Canadian
subsidiary, formed in March 1995.
 
YEARS ENDED DECEMBER 31, 1994 AND DECEMBER 31, 1993
 
    Research  and  development  costs  increased  to  $6,991,000  in  1994  from
$3,596,000  in 1993  due to  expansion of  Khepri's scientific  programs and the
expenses of such  programs, the most  significant including increased  personnel
and  related expenses,  scientific and  general supply  expenditures and outside
services.
 
    General and  administrative  costs  increased to  $1,497,000  in  1994  from
$1,030,000  in  1993  mainly due  to  an  increase in  personnel,  including the
addition of a chief executive officer, and increased consulting, facilities  and
depreciation expenses.
 
    Net interest income decreased to $8,000 in 1994 from $113,000 in 1993 mainly
due  to lower interest income as a result of lower average cash balances in 1994
and higher interest expense in 1994 due to higher average borrowings in 1994.
 
LIQUIDITY AND CAPITAL RESOURCES
 
    At the  time  of  the  Merger,  Khepri  had  $3,697,000  of  cash  and  cash
equivalents,  including $1,947,000  which was  held by  the Canadian subsidiary.
Khepri also had approximately $500,000 of credit availability under a lease line
facility.
 
                           COMPARATIVE PER SHARE DATA
 
    The following table sets  forth certain per share  data of Arris and  Khepri
and  combined per share data on an unaudited pro forma basis after giving effect
to the  Merger described  herein. The  table assumes  that all  the  outstanding
shares  of Khepri will be  acquired through the issuance  of 1,933,460 shares of
Arris common stock (effectively a .1097 exchange ratio) in the Merger. This data
should be read in conjunction with  the unaudited pro forma condensed  financial
statements  and the separate historical financial statements of Arris and Khepri
and notes thereto  incorporated by reference  in this Proxy  Statement. The  pro
forma   combined   financial   data   and   supplemental   pro   forma  combined
 
                                       15
<PAGE>
financial data  are not  necessarily indicative  of the  operating results  that
would  have been achieved had the Merger been consummated as of the beginning of
the year nor is such data  necessarily indicative of future financial  condition
or results of operations.
 
<TABLE>
<CAPTION>
                                                                                                 FISCAL YEAR ENDED
                                                                                                 DECEMBER 31, 1995
                                                                                                 -----------------
<S>                                                                                              <C>
Arris:
  Loss per share...............................................................................      $   (2.71)
  Book value per share (1).....................................................................      $     .72
Khepri:
  Loss per share (2)...........................................................................      $    (.45)
  Book value per share (3).....................................................................      $     .08
Pro Forma combined Loss Per Share:
  Per Arris share (4)..........................................................................      $    (.96)
  Equivalent per Khepri share (5)..............................................................      $    (.11)
Pro forma combined book value per share (4):
  Per Arris share..............................................................................      $     .72
  Equivalent per Khepri share (5)..............................................................      $     .08
</TABLE>
 
- - ------------------------
(1)  The historical book  value per share is  computed by dividing stockholders'
    equity by the number of shares of Common Stock outstanding at the end of the
    year.
 
(2) Weighted  average shares  outstanding includes  common stock  and  preferred
    stock, included on an as-if-converted basis.
 
(3)  The  historical book  value per  share  of Khepri  is computed  by dividing
    stockholders' equity immediately preceding  the acquisition (as of  December
    22, 1995) by the aggregate number of shares of Khepri's Common and Preferred
    Stock outstanding at December 22, 1995.
 
(4)  The  write-off of  acquired in-process  research  and development  has been
    eliminated from  the  pro  forma combined  loss  per  share since  it  is  a
    non-recurring  charge  directly  attributable  to the  Merger.  It  has been
    included in the pro forma combined book  value per share, as the charge  had
    been accrued as of December 31, 1995.
 
(5)  Calculated by multiplying the Arris  proforma combined per share amounts by
    the exchange ratio of .1097.
 
PRO FORMA FINANCIAL INFORMATION
 
    Unaudited pro  forma financial  statements for  the combined  operations  of
Arris  and Khepri  for the  year ended  December 31,  1995, are  incorporated by
reference from the Current Report on Form 8-K filed by Arris on January 5, 1996,
as amended on February 5, 1996.
 
OTHER INFORMATION
 
    A public  fairness  hearing  was  held at  the  offices  of  the  California
Department  of Corporations,  Sacramento, California,  on December  14, 1995, in
connection with the Merger, pursuant to  Section 3(a)(10) of the Securities  Act
of 1933, as amended.
 
    The  high and low sale prices per share of the Company's Common Stock on the
Nasdaq National Market on November  7, 1995, the trading  day prior to the  date
the transaction was announced, were $10.75 and $9.50, respectively.
 
    Representatives of Ernst & Young LLP, the Company's independent auditors are
expected  to be present at the Annual Meeting, will have the opportunity to make
a statement if they desire to do so, and are expected to be available to respond
to stockholder questions.
 
                                       16
<PAGE>
                                   PROPOSAL 3
                 APPROVAL OF THE ISSUANCE OF ARRIS COMMON STOCK
                        TO SHAREHOLDERS OF KHEPRI CANADA
                    IN CONNECTION WITH ARRIS' ACQUISITION OF
                          KHEPRI PHARMACEUTICALS, INC.
 
BACKGROUND
 
    In December  1995,  Arris  acquired  Khepri  in  a  transaction  more  fully
described in Proposal 2. As part of the Merger, Arris assumed certain rights and
obligations  under  existing agreements  between Khepri,  Khepri Pharmaceuticals
Canada, Inc. (a  50% owned subsidiary  of Khepri referred  to herein as  "Khepri
Canada")  and two Canadian  investors (the "Class  B Shareholders"), and entered
into amendments  to two  of such  agreements. Under  the terms  of such  amended
agreements,  Arris and the Class B Shareholders will make additional investments
in Khepri Canada in exchange for additional shares of Khepri Canada stock (Class
B Shares in the case  of the Class B  Shareholders), provided neither Arris  nor
such  Class B  Shareholders terminate  the obligations  to make  such additional
investments prior  to July  1, 1996.  Class  B Shares  issued pursuant  to  such
additional  investments will be exchangeable for shares of Arris Common Stock on
or after March 24, 1998, as more fully described below.
 
    The Company's Common Stock  trades on the Nasdaq  National Market. The  NASD
rules  applicable to  Arris provide  that Arris'  stockholders must  approve the
issuance of  Arris Common  Stock issued  in connection  with the  Merger to  the
extent  the number of shares  of Arris Common Stock to  be issued exceeds 20% of
the number of shares of Arris Common Stock outstanding prior to the Merger.
 
    Proposal 3  seeks the  approval, to  the extent  required by  the NASD  rule
described above, for the issuance of shares of Arris Common Stock to the Class B
Shareholders of Khepri Canada sufficient to meet the exchange right of the Class
B  Shareholders with respect to Class B Shares  they acquire on or after July 1,
1996, as more fully described below.
 
    THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 3.
 
DESCRIPTION OF TRANSACTION
 
    Khepri  Canada  was  formed  in  March  1995  as  a  subsidiary  of  Khepri,
incorporated  under the  laws of Quebec,  Canada and located  in Montreal. Fifty
percent (50%) of  the outstanding  capital stock of  Khepri Canada  are Class  A
Shares and are owned by Arris, and the remaining fifty percent (50%) are Class B
Shares  and are held in  equal amounts by the Class  B Shareholders. The Class A
Shares and Class B Shares have equal voting rights.
 
    On March 24, 1995, Khepri entered into a Subscription Agreement and a  Stock
Exchange  Agreement with Khepri Canada and  the Class B Shareholders pursuant to
which Khepri and the Class B Shareholders were obligated to make certain  equity
investments in Khepri at specified times (the "Khepri Canada Agreements"). Under
the  terms  of the  Khepri Canada  Agreements,  Class B  Shares would  have been
convertible into shares  of Khepri Class  D Preferred Stock.  The Khepri  Canada
Agreements were amended in connection with the Merger.
 
    The Khepri Canada Agreements, as amended, provide for additional investments
(the  "Additional Investments") in Khepri Canada as  follows: on each of July 1,
1996, and March 24, 1997,  Arris will invest CDN  $666,667 in Khepri Canada  and
each  of  the two  Class B  Shareholders  will invest  CDN $1,333,333  in Khepri
Canada. In  exchange for  the Additional  Investments, on  each such  investment
date: (i) Arris will receive that number of Class A Shares equal to CDN $666,667
divided  by the then current CDN dollar equivalent of U.S. $0.45 (if on the July
1, 1996 investment  date) or U.S.  $0.54 (if  on the March  24, 1997  investment
date);  and (ii) the two  Class B Shareholders will  each receive that number of
Class B  Shares  equal  to  CDN  $1,333,333 divided  by  the  then  current  CDN
equivalent  of U.S. $1.80 (if on the July 1, 1996 investment date) or U.S. $2.16
(if on the March 24, 1997 investment date).
 
                                       17
<PAGE>
    The Khepri Canada Agreements, as amended, give each of Arris and the Class B
Shareholders the right to terminate, prior  to July 1, 1996, the obligations  to
make  the Additional  Investments. If  such obligations  are so  terminated, the
Class B Shareholders would have the right to exchange their currently held Class
B Shares for shares of Arris Common Stock at an exchange rate of 0.12766  shares
of  Arris Common Stock per Class B Share (the "Exchange Ratio"), resulting in an
aggregate of 161,418 shares  of Arris Common Stock.  If the obligations to  make
the  Additional Investments  are not terminated,  the Class  B Shareholders will
have the right, on  or after March  24, 1998, to exchange  their Class B  Shares
then  held for shares of Arris Common Stock at the Exchange Ratio. The effective
price per  share  of Arris  Common  Stock  that will  be  paid by  the  Class  B
Shareholders  if the Khepri  Canada Agreements are not  terminated is $14.10 for
the July 1, 1996 investment  and $16.92 for the  March 24, 1997 investment.  The
exact  number of such shares of Arris Common Stock is not presently determinable
as it is dependent  upon the currency  exchange rate for  Canadian funds at  the
time of the Additional Investments.
 
    Upon  the exchange of Class B Shares  for Arris Common Stock, whether or not
the obligation to  make the Additional  Investments is terminated,  the Class  B
Shareholders  will be  entitled to certain  registration rights  with respect to
shares of Arris Common Stock received in the exchange.
 
    Pursuant to Section  6(i)(1)(c)(ii) of Part  III of Schedule  D to the  NASD
By-Laws,  the stockholders of  Arris are required, by  majority vote, to approve
any issuance of stock in connection with the Merger which constitutes an  amount
equal  to more than twenty percent (20%)  of the outstanding capital stock prior
to the Merger. As a result, Arris may not issue Arris Common Stock to the  Class
B  Shareholders in exchange for  Class B Shares acquired  in connection with the
Additional  Investments  unless  this  Proposal  3  is  approved  by  the  Arris
stockholders.  If Proposal 3 is  not approved, Arris will  exercise its right to
terminate the Khepri Canada Agreements.
 
    The Board of Directors is recommending a vote in favor of this Proposal 3 in
order to  give  the  Company  the flexibility  to  continue  the  Khepri  Canada
Agreements.  Such agreements  not only  provide additional  funding to  Arris on
potentially attractive  terms but  also permit  the Company  to receive  certain
Canadian   and  Province  of  Quebec   benefits  associated  with  research  and
development conducted by Canadian private  companies in Canada and the  Province
of  Quebec. Even if the stockholders of Arris approve this Proposal 3, the Board
of Directors will  retain the  right (through June  30, 1996)  to terminate  the
Khepri  Canada Agreements if it subsequently determines that such termination is
in the best interests of the Company.
 
                                   PROPOSAL 4
                  APPROVAL OF THE 1989 STOCK PLAN, AS AMENDED
 
    In May 1989, the  Board of Directors adopted  the Company's 1989 Stock  Plan
(the  "1989 Plan"). As a result of a  series of amendments, at February 29, 1996
there were  2,117,500  shares  of  the Company's  Common  Stock  authorized  for
issuance under the 1989 Plan.
 
    At  February  29, 1996,  options (net  of  canceled, repurchased  or expired
options) covering an aggregate of 2,107,273 shares of the Company's Common Stock
had been granted under  the 1989 Plan  and 10,227 shares  (plus any shares  that
might  in the future be returned to the  reserve as a result of cancellations or
expiration of options) remained available for future grants under the 1989 Plan.
In December and  February 1996,  options covering an  additional 190,000  shares
were  granted subject to stockholder approval of the amendment to the 1989 Plan,
pursuant  to  this  Proposal  4.  See  "Option  Grants  Subject  to  Stockholder
Approval." During the last fiscal year, under the 1989 Plan, the Company granted
to the officers named in the Summary Compensation Table the options described in
the  Option Grants  Table and  granted to  all employees  as a  group (excluding
executive officers) options  to purchase  368,925 shares at  exercise prices  of
$6.19  to $13.08 per share. No options have  been granted under the 1989 Plan to
any of the current directors who are not officers of the Company.
 
                                       18
<PAGE>
    In February 1996, the Board approved an amendment to the 1989 Plan,  subject
to  stockholder  approval,  to  increase the  number  of  shares  authorized for
issuance under the 1989 Plan by 550,000 shares, to a total of 2,667,500  shares.
The  Board adopted  this amendment  to ensure that  the Company  can continue to
grant options under the 1989 Plan to employees at levels determined  appropriate
by the Board and the Compensation Committee.
 
    Stockholders  are requested in this Proposal 4  to approve the 1989 Plan, as
amended. If the stockholders fail to  approve this Proposal 4, options  approved
by the Board covering 190,000 shares could not be exercised under the 1989 Plan.
The  affirmative vote  of the  holders of  a majority  of the  shares present in
person or represented  by proxy  and entitled  to vote  at the  meeting will  be
required  to  approve the  1989 Plan,  as amended.  Abstentions will  be counted
toward the tabulation of votes cast  on proposals presented to the  stockholders
and  will have the same  effect as negative votes.  Broker non-votes are counted
towards a quorum,  but are not  counted for any  purpose in determining  whether
this matter has been approved.
 
    THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 4.
 
THE 1989 STOCK PLAN
 
    The essential features of the 1989 Plan are outlined below.
 
GENERAL
 
    The  1989 Plan was adopted by the Board of Directors in May 1989 and amended
in November 1990,  March 1992,  April 1993, April  1994 and  February 1995,  and
approved  by  the  stockholders from  time  to  time thereafter.  The  1989 Plan
provides for the grant of both incentive and nonstatutory stock options as  well
as  restricted stock purchase rights. Incentive  stock options granted under the
1989 Plan  are intended  to  qualify as  "incentive  stock options"  within  the
meaning  of Section 422  of the Internal  Revenue Code of  1989, as amended (the
"Code"). Nonstatutory stock options granted under the 1989 Plan are intended not
to qualify as incentive  stock options under the  Code. See "Federal Income  Tax
Information"  for  a  discussion of  the  tax  treatment of  the  various awards
provided under the 1989 Plan.
 
PURPOSE
 
    The purpose of the 1989 Plan  is to attract and retain qualified  personnel,
to  provide additional incentives to employees,  officers and consultants of the
Company and to promote  the success of the  Company's business. Pursuant to  the
1989  Plan, the Company may grant or  issue incentive stock options to employees
and officers  and  nonstatutory  stock  options  or  stock  purchase  rights  to
consultants, employees and officers. Directors who are not salaried employees of
or  consultants to the Company are not eligible to participate in the 1989 Plan.
All  the  Company's  approximately  127  employees  presently  are  eligible  to
participate in the 1989 Plan.
 
ADMINISTRATION
 
    The  1989 Plan is administered by the Board of Directors of the Company. The
Board has the power to construe and interpret the 1989 Plan and, subject to  the
provisions  of the 1989 Plan, to determine the  persons to whom and the dates on
which awards will be granted, the number of shares to be subject to each  award,
the time or times during the term of each award within which all or a portion of
such  award may be exercised, the exercise  price, the type of consideration and
other terms  of the  award. The  Board of  Directors is  authorized to  delegate
administration  of the 1989 Plan to a committee and has delegated such authority
to the Compensation Committee and, for grants to employees other than  executive
officers,  the Option Committee. As  used herein with respect  to the 1989 Plan,
the "Board" refers  to the Compensation  Committee and the  Option Committee  as
well as to the Board of Directors itself.
 
    The  Company currently limits the directors who  may serve as members of the
Compensation Committee to  those who  are "outside  directors." This  limitation
excludes from the Compensation
 
                                       19
<PAGE>
Committee  (i) current  employees of the  Company, (ii) former  employees of the
Company receiving compensation for  past services (other  than benefits under  a
tax-qualified  retirement  plan),  (iii)  current  and  former  officers  of the
Company, (iv) directors currently receiving direct or indirect compensation from
the Company in any capacity (other than  as a director), unless any such  person
is otherwise considered an "outside director" under applicable federal guidance.
 
ELIGIBILITY
 
    No stock option may be granted under the 1989 Plan to any person who, at the
time  of the grant, owns (or is deemed to own) stock possessing more than 10% of
the total combined voting power of the Company or any affiliate of the  Company,
unless  the option exercise price  is at least 110% of  the fair market value of
the stock subject to the option on the date of grant, and the term of the option
does not exceed five years from the date of grant. For incentive stock  options,
the  aggregate fair market value, determined at the time of grant, of the shares
of Common Stock with respect to which such options are exercisable for the first
time by  an optionee  during any  calendar year  (under all  such plans  of  the
Company and its affiliates) may not exceed $100,000.
 
    Under the 1989 Plan, no individual may be granted options covering more than
300,000  shares of Common Stock in any  calendar year. The principal purpose for
such a per-employee  limitation is to  comply with IRS  regulations that  permit
certain  performance-based compensation, including  compensation attributable to
stock options that  meet specified criteria,  to be exempt  from the  $1,000,000
limitation  under Section 162(m) of the Code  on the amount that may be deducted
by publicly held corporations  for compensation paid  to certain employees.  See
"Federal  Income Tax Information." To  date, the Company has  not granted to any
employee in any calendar year options to purchase a number of shares equal to or
greater than  the  limitation and  does  not  currently have  any  intention  of
granting  such number  of options  to any employee.  There can  be no assurance,
however, that the Board will not determine in some future circumstances that  it
would  be in  the best interests  of the  Company and its  stockholders to grant
options to purchase such number of shares to a single employee during a calendar
year.
 
STOCK SUBJECT TO THE 1989 PLAN
 
    If options granted under the 1989 Plan expire or otherwise terminate without
being exercised, the Common Stock not  purchased pursuant to such options  again
becomes available for issuance under the 1989 Plan.
 
    The  permissible terms of options and restricted stock purchase rights under
the 1989 Plan are
described below. Individual option grants  and restricted stock purchase  rights
may  be more  restrictive as to  any or  all of the  permissible terms described
below.
 
TERMS OF OPTIONS
 
   
    EXERCISE PRICE;  PAYMENT.   The exercise  price of  incentive stock  options
under  the 1989 Plan  may not be less  than the fair market  value of the Common
Stock subject to the option on the date  of the option grant, and in some  cases
(see  "Eligibility" above), may not be less than 110% of such fair market value.
The exercise price of nonstatutory options under  the 1989 Plan may not be  less
than  85% of the fair market value of  the Common Stock subject to the option on
the date of the option grant, and also  in some cases may not be less than  110%
of such fair market value (see "Eligibility" above). If options are granted with
exercise  prices  below  market  value,  however,  deductions  for  compensation
attributable to the exercise of such options could be limited by Section  162(m)
of  the Code. See "Federal Income Tax Information." In its discretion, the Board
may later reduce  the exercise  price of  any option  to the  then current  fair
market  value of the  Common Stock. Deductions  for compensation attributable to
the exercise of  such options could  also be  limited by Section  162(m) of  the
Code.  At  May 2,  1996,  the closing  price of  the  Company's Common  Stock as
reported on the Nasdaq National Market was $14.875 per share.
    
 
                                       20
<PAGE>
   
    The exercise  price of  options granted  under the  1989 Plan  must be  paid
either:  (a)  in  cash at  the  time the  option  is  exercised; or  (b)  at the
discretion of the Board, (i)  by delivery of other  Common Stock of the  Company
(ii)  pursuant to a deferred  payment arrangement or (iii)  in any other form of
legal consideration acceptable to the Board.
    
 
    OPTION EXERCISE.  Options granted under the 1989 Plan may become exercisable
in cumulative increments ("vest") as determined by the Board. Shares covered  by
currently  outstanding options under the 1989 Plan typically vest at the rate of
12.5% of the shares subject to the option at the end of the first six months and
1/48th of the shares subject to the option each month for 42 months  thereafter.
Shares  covered by  options granted  in the  future under  the 1989  Plan may be
subject to different vesting  terms. The Board has  the power to accelerate  the
time  during which  an option may  be exercised.  To the extent  provided by the
terms of an  option, an optionee  may satisfy  any federal, state  or local  tax
withholding obligation relating to the exercise of such option by a cash payment
upon  exercise, by authorizing  the Company to  withhold a portion  of the stock
otherwise issuable to  the optionee, by  delivering already owned  stock of  the
Company or by a combination of these means.
 
    TERM.   The maximum term of options under  the 1989 Plan is 10 years, except
that in  certain cases  (see  "Eligibility") the  maximum  term is  five  years.
Options  under  the 1989  Plan terminate  ninety days  after termination  of the
optionee's employment or  relationship as  a consultant  of the  Company or  any
subsidiary  of the Company, unless (a) such  termination is due to such person's
permanent and  total disability  (as defined  in the  Code), in  which case  the
option  may, but need not,  provide that it may be  exercised at any time within
twelve months of such  termination; (b) the optionee  dies while employed by  or
serving  as a  consultant of  the Company  or any  affiliate of  the Company, or
within 90 days after termination of such relationship, in which case the  option
may,  but need not, provide  that it may be exercised  (to the extent the option
was exercisable at the time of the optionee's death) within twelve months of the
optionee's death by the person or persons to whom the rights to such option pass
by will or by  the laws of descent  and distribution; or (c)  the option by  its
terms  specifically provides  otherwise. Individual  options by  their terms may
provide for exercise  within a longer  period of time  following termination  of
employment  or the consulting relationship. The option term may also be extended
in the event that exercise of the option within these periods is prohibited  for
specified reasons.
 
TERMS OF RESTRICTED STOCK PURCHASE RIGHTS
 
    PURCHASE  PRICE;  TERM.    The  purchase  price  under  each  stock purchase
agreement may not be less than 50% of the fair market value of the Common  Stock
subject  to  the restricted  stock  purchase right  on  the date  such  right is
granted. The term of such restricted stock purchase right may not exceed 30 days
or such longer time as may be determined by the Board.
 
    REPURCHASE.  Shares of the  Common Stock sold under  the 1989 Plan may,  but
need  not,  be  subject  to a  repurchase  option  in favor  of  the  Company in
accordance with  a vesting  schedule determined  by the  Board. In  the event  a
purchaser  ceases  to be  an  employee of  or consultant  to  the Company  or an
affiliate of the Company, the Company may repurchase any or all of the shares of
the Common Stock held by that purchaser that  have not vested as of the date  of
termination at the original price paid by the purchaser and the repurchase price
may be paid by cancellation of an indebtedness of the purchaser to the Company.
 
ADJUSTMENT PROVISIONS
 
    If  there is any change in the stock  subject to the 1989 Plan or subject to
any  option  granted  under  the  1989  Plan  (through  merger,   consolidation,
reorganization,  recapitalization,  stock dividend,  dividend in  property other
than cash, stock split, liquidating dividend, combination of shares, exchange of
shares, change in corporate structure or  otherwise), the 1989 Plan and  options
outstanding  thereunder will be  appropriately adjusted as to  the class and the
maximum number of  shares subject  to such plan,  the maximum  number of  shares
which  may be  granted to  an employee  during a  calendar year,  and the class,
number of  shares and  price per  share  of stock  subject to  such  outstanding
options.
 
                                       21
<PAGE>
EFFECT OF CERTAIN CORPORATE EVENTS
 
    The  1989 Plan provides that, in the event  of a merger of the Company, such
options shall be  assumed or  equivalent options substituted  by each  successor
corporation or a parent or subsidiary of such successor corporation.
 
DURATION, AMENDMENT AND TERMINATION
 
    The  Board  may  suspend  or terminate  the  1989  Plan  without stockholder
approval at any time. Unless sooner terminated, the 1989 Plan will terminate  in
May 1999.
 
    The  Board may also  amend the 1989 Plan  at any time or  from time to time.
However, no amendment will be effective  unless approved by the stockholders  of
the  Company within twelve months  before or after its  adoption by the Board if
the  amendment  would:  (a)  modify  the  requirements  as  to  eligibility  for
participation  (to the extent such modification requires stockholder approval in
order for the Plan to  satisfy Section 422 of the  Code, if applicable, or  Rule
16b-3  ("Rule 16b-3") of  the Securities Exchange  Act of 1934,  as amended (the
"Exchange Act")); (b) increase the number  of shares reserved for issuance  upon
exercise  of options; or (c) change any other provision of the Plan in any other
way if such modification requires stockholder  approval in order to comply  with
Rule 16b-3 or satisfy the requirements of Section 422 of the Code. The Board may
submit any other amendment to the 1989 Plan for stockholder approval, including,
but  not limited to, amendments intended  to satisfy the requirements of Section
162(m) of the  Code regarding  the exclusion  of performance-based  compensation
from  the  limitation  on  the deductibility  of  compensation  paid  to certain
employees.
 
RESTRICTIONS ON TRANSFER
 
    Under the  1989 Plan,  an option  may  not be  transferred by  the  optionee
otherwise than by will or by the laws of descent and distribution and during the
lifetime of the optionee, may be exercised only by the optionee.
 
FEDERAL INCOME TAX INFORMATION
 
    INCENTIVE  STOCK OPTIONS.   Incentive stock options under  the 1989 Plan are
intended to be eligible for the favorable federal income tax treatment  accorded
"incentive stock options" under the Code.
 
    There  generally are no  federal income tax consequences  to the optionee or
the Company by reason  of the grant  or exercise of  an incentive stock  option.
However,  the exercise of an incentive stock option may result in the imposition
of or  an increase  in liability  of the  optionee for  alternative minimum  tax
liability.
 
    If  an optionee holds stock acquired  through exercise of an incentive stock
option for at least two years from the  date on which the option is granted  and
at  least one  year from  the date on  which the  shares are  transferred to the
optionee upon exercise of the option, any gain or loss on a disposition of  such
stock  will be  a long-term  capital gain  or loss.  Generally, if  the optionee
disposes of the stock before the  expiration of either of these holding  periods
(a  "disqualifying disposition"), at the time  of disposition, the optionee will
recognize taxable ordinary income equal to the  lesser of (i) the excess of  the
stock's  fair market value on  the date of exercise  over the exercise price, or
(ii) the  optionee's  actual  gain,  if  any, on  the  purchase  and  sale.  The
optionee's additional gain, or any loss, upon the disqualifying disposition will
be  a capital gain or  loss, which will be  long-term or short-term depending on
whether the  stock was  held for  more than  one year.  Long-term capital  gains
currently  are generally  subject to lower  tax rates than  ordinary income. The
maximum capital gains  rate for  federal income  tax purposes  is currently  28%
while the maximum ordinary income rate is effectively 39.6% at the present time.
Slightly  different rules  may apply to  optionees who acquire  stock subject to
certain repurchase options or who are  subject to Section 16(b) of the  Exchange
Act.
 
    To  the  extent  the optionee  recognizes  ordinary  income by  reason  of a
disqualifying disposition, the  Company will generally  be entitled (subject  to
the  requirement of reasonableness, the provisions of Section 162(m) of the Code
and the satisfaction of a tax reporting obligation) to a corresponding  business
expense deduction in the tax year in which the disqualifying disposition occurs.
 
                                       22
<PAGE>
    NONSTATUTORY  STOCK OPTIONS.   Nonstatutory stock options  granted under the
1989 Plan generally have the following federal income tax consequences:
 
    There are no tax consequences  to the optionee or  the Company by reason  of
the  grant of a nonstatutory stock option. Upon exercise of a nonstatutory stock
option, the optionee normally  will recognize taxable  ordinary income equal  to
the  excess of the  stock's fair market value  on the date  of exercise over the
option exercise  price. Generally,  with respect  to employees,  the Company  is
required  to withhold from regular wages or supplemental wage payments an amount
based  on  the  ordinary  income  recognized.  Subject  to  the  requirement  of
reasonableness,   the  provisions  of  Section  162(m)   of  the  Code  and  the
satisfaction of  a  tax reporting  obligation,  the Company  will  generally  be
entitled  to a business  expense deduction equal to  the taxable ordinary income
realized by  the optionee.  Upon disposition  of the  stock, the  optionee  will
recognize  a capital gain  or loss equal  to the difference  between the selling
price and the sum of the amount  paid for such stock plus any amount  recognized
as  ordinary income upon exercise of the option.  Such gain or loss will be long
or short-term depending on whether  the stock was held  for more than one  year.
Slightly  different rules  may apply to  optionees who acquire  stock subject to
certain repurchase options or who are  subject to Section 16(b) of the  Exchange
Act.
 
    RESTRICTED  STOCK.  Restricted  stock granted under  the 1989 Plan generally
has the following federal income tax consequences:
 
   
    Upon acquisition  of stock  under a  restricted stock  award, the  recipient
normally  will  recognize taxable  ordinary income  equal to  the excess  of the
stock's fair  market value  over the  purchase price,  if any.  However, to  the
extent  the  stock is  subject  to certain  types  of vesting  restrictions, the
taxable event will be  delayed until the vesting  restrictions lapse unless  the
recipient elects to be taxed on receipt of the stock. Generally, with respect to
employees,   the  Company  is  required  to   withhold  from  regular  wages  or
supplemental wage payments an  amount based on  the ordinary income  recognized.
Subject  to the requirement of reasonableness,  the provisions of Section 162(m)
of the Code and the satisfaction of a tax reporting obligation, the Company will
generally be  entitled to  a business  expense deduction  equal to  the  taxable
ordinary  income realized by  the recipient. Upon disposition  of the stock, the
recipient will recognize a capital gain or loss equal to the difference  between
the  selling price and the sum  of the amount paid for  such stock, if any, plus
any amount recognized as  ordinary income upon acquisition  (or vesting) of  the
stock.  Such gain or  loss will be  long or short-term  depending on whether the
stock was held for more than one year from the date ordinary income is measured.
Slightly different  rules may  apply to  persons who  acquire stock  subject  to
forfeiture under Section 16(b) of the Exchange Act.
    
 
    POTENTIAL  LIMITATION ON COMPANY DEDUCTIONS.   As part of the Omnibus Budget
Reconciliation Act of 1993,  the U.S. Congress amended  the Code to add  Section
162(m),   which  denies  a  deduction  to  any  publicly  held  corporation  for
compensation paid to  certain employees  in a taxable  year to  the extent  that
compensation  exceeds $1,000,000  for a  covered employee.  It is  possible that
compensation attributable to awards under the 1989 Plan, when combined with  all
other types of compensation received by a covered employee from the Company, may
cause this limitation to be exceeded in any particular year.
 
    Certain   kinds  of  compensation,  including  qualified  "performance-based
compensation," are  disregarded for  purposes of  the deduction  limitation.  In
accordance  with Treasury regulations  issued under Section  162(m) of the Code,
compensation attributable  to stock  options will  qualify as  performance-based
compensation,  provided that: (i)  the stock award  plan contains a per-employee
limitation on the number of shares for which stock options may be granted during
a specified  period;  (ii)  the  per-employee  limitation  is  approved  by  the
shareholders;  (iii) the award is granted  by a compensation committee comprised
solely of "outside directors"; and  (iv) the exercise price  of the award is  no
less  than the fair market  value of the stock on  the date of grant. Restricted
stock qualifies as performance-based compensation under these proposed  Treasury
regulations  only  if: (i)  the  award is  granted  by a  compensation committee
comprised   solely    of    "outside    directors";   (ii)    the    award    is
 
                                       23
<PAGE>
granted  (or exercisable) only upon the  achievement of an objective performance
goal established in writing by the  compensation committee while the outcome  is
substantially  uncertain; (iii) the compensation  committee certifies in writing
prior to the granting (or exercisability) of the award that the performance goal
has been satisfied; and  (iv) prior to the  granting (or exercisability) of  the
award, shareholders have approved the material terms of the award (including the
class  of employees eligible for such award,  the business criteria on which the
performance goal is based, and the maximum amount (or formula used to  calculate
the amount) payable upon attainment of the performance goal).
 
OPTION GRANTS SUBJECT TO STOCKHOLDER APPROVAL
 
    The  following table  presents certain  information with  respect to options
granted under the 1989 Plan,  subject to approval of  the amendment of the  1989
Plan  by  the stockholders,  to (i)  each  of the  executive officers,  (ii) the
executive officers as a group, and (iii) all non-executive officer employees  as
a  group. Non-employee directors  are not eligible for  options grants under the
1989 Plan.
 
                               NEW PLAN BENEFITS
 
<TABLE>
<CAPTION>
                                                                                                   NUMBER OF SHARES
                                                                                                      SUBJECT TO
NAME AND POSITION                                                               DOLLAR VALUE (1)    OPTIONS GRANTED
- - ------------------------------------------------------------------------------  -----------------  -----------------
<S>                                                                             <C>                <C>
John P. Walker                                                                            N/A              40,000
 President and Chief Executive Officer
Michael J. Ross, Ph.D.                                                                    N/A              20,000
 Executive Vice President and Chief Technical Officer
Heinz W. Gschwend, Ph.D.                                                                  N/A              20,000
 Vice President, Research and Development, Inflammation
Daniel H. Petree                                                                          N/A              20,000
 Vice President, Corporate Development and Chief Financial Officer
All Executive Officers as a Group                                                         N/A             100,000
All Non-Executive Officer Employees as a Group                                            N/A              90,000
</TABLE>
 
- - ------------------------
(1) All shares were granted  at the fair market value  of Arris Common Stock  at
    the  date of grant,  and will have  a determinable dollar  value only if the
    fair market value of  the Common Stock  on the date  of exercise is  greater
    than the fair market value on the date of grant. For an example of potential
    realizable  option values, see the table "Option Grants in Fiscal Year 1995"
    under the heading "Executive Compensation."
 
                                   PROPOSAL 5
              APPROVAL OF EMPLOYEE STOCK PURCHASE PLAN, AS AMENDED
 
    In October  1993,  the  Board  of Directors  adopted  and  the  stockholders
subsequently  approved, the Employee  Stock Purchase Plan  (the "Purchase Plan")
authorizing the issuance  of 150,000 shares  of the Company's  Common Stock.  At
February  29, 1996,  an aggregate  of 104,412 shares  had been  issued under the
Purchase Plan and  only 45,488 shares  remained for the  grant of future  rights
under  the Plan. In February 1996, the Board of Directors of the Company adopted
an amendment to the  Purchase Plan to increase  the number of shares  authorized
for  issuance under the  Purchase Plan by  100,000 shares to  a total of 250,000
shares. This amendment is intended to afford the Company greater flexibility  in
providing  employees with  stock incentives and  to ensure that  the Company can
continue to  provide such  incentives at  levels determined  appropriate by  the
Board.  During the last fiscal year, shares were purchased in the amounts and at
the weighted average prices per share under the Purchase Plan as follows: 47,045
shares at a  weighted average price  of $4.97 per  share, all current  executive
officers  as  a  group  13,230  shares  ($4.89),  and  all  employees (excluding
executive officers) as a group 33,815 shares ($5.00).
 
                                       24
<PAGE>
    Stockholders  are requested in this Proposal 5 to approve the Purchase Plan,
as amended. The  affirmative vote of  the holders  of a majority  of the  shares
present  in person or represented  by proxy and entitled  to vote at the meeting
will be required to approve the  Purchase Plan, as amended. Abstentions will  be
counted  toward  the tabulation  of  votes cast  on  proposals presented  to the
stockholders and will have the same  effect as negative votes. Broker  non-votes
are counted towards a quorum, but are not counted for any purpose in determining
whether this matter has been approved.
 
    THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 5.
 
EMPLOYEE STOCK PURCHASE PLAN
 
    The essential features of the Purchase Plan, as amended, are outlined below.
 
PURPOSE
 
    The purpose of the Purchase Plan is to provide a means by which employees of
the Company (and any parent or subsidiary of the Company designated by the Board
of Directors to participate in the Purchase Plan) may be given an opportunity to
purchase  Common Stock of the Company  through payroll deductions, to assist the
Company in retaining  the services of  its employees, to  secure and retain  the
services  of new employees, and to provide  incentives for such persons to exert
maximum  efforts  for  the  success  of  the  Company.  All  of  the   Company's
approximately 127 employees are eligible to participate in the Purchase Plan.
 
    The  rights to  purchase Common  Stock granted  under the  Purchase Plan are
intended to qualify as options issued under an "employee stock purchase plan" as
that term is defined in Section 423(b) of the Code.
 
ADMINISTRATION
 
    The Purchase Plan is administered by  the Board of Directors, which has  the
final  power to construe and interpret the  Purchase Plan and the rights granted
under it. The Board  has the power,  subject to the  provisions of the  Purchase
Plan,  to determine when and how rights  to purchase Common Stock of the Company
will be granted, the provisions of each offering of such rights (which need  not
be  identical), and  whether any  parent or subsidiary  of the  Company shall be
eligible to participate in  such plan. The Board  of Directors is authorized  to
delegate  administration of the  Purchase Plan to a  committee and has delegated
such authority to the Compensation Committee. As used herein with respect to the
Purchase Plan, the "Board" refers to  the Compensation Committee as well as  the
Board itself.
 
OFFERINGS
 
    Under  the  Purchase Plan,  the Board  from  time to  time may  institute an
offering consisting  of rights  granted to  all eligible  employees to  purchase
Common  Stock periodically while such offering  is in effect. Each such offering
may have a duration  of no more than  twenty-seven months. The Board  determines
the  duration of each offering and establishes one or more purchase dates during
the offering on which shares will be purchased by participating employees. Under
the terms of the offerings  approved by the Board  to date, each offering  lasts
for  two years, except that if, on a purchase date during an offering, the price
of the Company's Common Stock on such purchase date is lower than it was at  the
start  of the  offering, then that  offering automatically terminates  and a new
offering begins  on the  following  day. Currently,  the Board  has  established
purchase dates to occur every six months, on each July 31, and January 31.
 
ELIGIBILITY
 
    Generally,  under  the  terms of  the  Purchase  Plan, any  employee  who is
customarily employed at  least 20 hours  per week and  five months per  calendar
year  by the Company (or  by any parent or  subsidiary of the Company designated
from time to  time by  the Board) on  the first  day of the  offering period  is
eligible  to participate in that offering,  provided that such employee has been
employed continuously for such  period (which may not  exceed two years) as  the
Board may establish as a service
 
                                       25
<PAGE>
requirement  for  participation.  In addition,  the  Board may  provide  for the
commencement of participation at specified dates during an offering by employees
who first meet the eligibility requirements after the first day of the offering.
Currently, a continuous  period of employment  of three months  is required  for
otherwise eligible employees to participate in the Purchase Plan.
 
    Notwithstanding  the foregoing, no employee is eligible for the grant of any
rights under the Purchase  Plan if, immediately after  such grant, the  employee
would  own, directly  or indirectly,  stock possessing 5%  or more  of the total
combined voting power or value of all classes of stock of the Company or of  any
parent or subsidiary of the Company (including any stock which such employee may
purchase  under all  outstanding rights and  options). Also,  under the Purchase
Plan no employee may be  granted rights that would  permit the purchase of  more
than $25,000 worth of Common Stock (determined by using the fair market value of
the  shares  at the  time  such rights  are  granted) under  all  employee stock
purchase plans of the Company  for each calendar year  in which such rights  are
outstanding. Under current and prior offerings, the Board has limited the amount
of  Common  Stock  that  any  participant could  purchase  to  5,000  shares per
offering. Effective with  the next offering  under the Purchase  Plan, which  is
scheduled  to  begin on  August  1, 1996,  a  participant may  purchase  on each
purchase date during an  offering no more  than the number  of shares of  Common
Stock  determined by  dividing $12,500  by the fair  market value  of the Common
Stock on the first day of the offering.
 
PARTICIPATION IN THE PLAN
 
    Eligible employees become participants in the Purchase Plan by delivering to
the Company, prior to the date  selected by the Board, an agreement  authorizing
payroll  deductions from such employees' total compensation during the offering.
The Purchase  Plan  permits payroll  deductions  of up  to  15%, but  under  the
offerings  made to date the Board has limited payroll deductions to no more than
10% of an employee's total compensation.
 
PURCHASE PRICE
 
    The purchase price per share  at which Common Stock  is sold in an  offering
under  the Purchase Plan is the  lower of (a) 85% of  the fair market value of a
share of Common Stock on the date of commencement of the offering, or (b) 85% of
the fair market value of a share of Common Stock on the applicable purchase date
for the purchase of such Common Stock.
 
ACCUMULATION OF PURCHASE PRICE; PAYROLL DEDUCTIONS
 
    The purchase price of the Common Stock is accumulated by payroll  deductions
over  the period of the  offering. Payroll deductions of  a participant begin on
the date specified in the offering and  may be increased or reduced on the  date
or  dates  specified  in  the  offering.  All  payroll  deductions  made  for  a
participant are credited to  the participant's account  under the Purchase  Plan
and  are deposited with the general funds  of the Company. A participant may not
make any additional payments into such account unless permitted under the  terms
of an offering.
 
PURCHASE OF STOCK
 
    By  executing an agreement to participate  in an offering under the Purchase
Plan, the employee becomes entitled to  purchase shares under such offering.  In
connection  with offerings made  under the Purchase Plan,  the Board specifies a
maximum number of shares  any participant may be  granted the right to  purchase
and  the maximum aggregate number  of shares which may  be purchased pursuant to
such offering by  all participants. Under  the Purchase Plan,  if the  aggregate
number of shares to be purchased upon exercise of rights granted in the offering
would  exceed the  maximum aggregate  number, the  Board would  make a  pro rata
allocation of shares  available in a  uniform and equitable  manner. Unless  the
participant's  participation is  discontinued, the  right to  purchase shares is
exercised automatically  on each  purchase  date at  the applicable  price.  See
"Withdrawal" below.
 
                                       26
<PAGE>
WITHDRAWAL
 
    A  participant may  withdraw from  a given  offering by  terminating payroll
deductions for  such  offering  and  delivering  to  the  Company  a  notice  of
withdrawal  from the offering. Such  withdrawal must be elected  by the time set
forth in the applicable offering.
 
    Upon any withdrawal from  an offering by the  participant, the Company  will
distribute  to  the  participant,  without  interest,  the  accumulated  payroll
deductions in  the  participant's account  under  the Purchase  Plan,  less  any
accumulated  deductions  previously  applied to  the  purchase of  stock  on the
participant's  behalf  during  such  offering  period,  and  such  participant's
interest  in the offering will be  automatically terminated. The employee is not
entitled to again participate in such offering. An employee's withdrawal from an
offering  will  not  have  any  effect  upon  such  employee's  eligibility   to
participate in subsequent offerings under the Purchase Plan.
 
TERMINATION OF EMPLOYMENT
 
    Rights  granted pursuant to  any offering under  the Purchase Plan terminate
immediately upon cessation of a participant's employment for any reason, and the
Company will  distribute  to such  participant,  without interest,  all  of  the
accumulated payroll deductions from the participant's account under the Purchase
Plan.
 
RESTRICTIONS ON TRANSFER
 
    Rights  granted  under the  Purchase Plan  are not  transferable and  may be
exercised only by the person to whom such rights are granted.
 
DURATION, AMENDMENT AND TERMINATION
 
    The Board may  suspend or terminate  the Purchase Plan  at any time.  Unless
terminated earlier, such plan will terminate on December 31, 2002.
 
    The  Board may  amend the  Purchase Plan  at any  time. To  be effective any
amendment of the Purchase  Plan must be approved  by the stockholders within  12
months  of its  adoption by the  Board if  the amendment would  (a) increase the
number of shares of Common Stock reserved for issuance under the Purchase  Plan,
(b)  modify the  requirements relating to  eligibility for  participation in the
Purchase Plan, or  (c) modify  any other  provision of  the Purchase  Plan in  a
manner  that  would materially  increase the  benefits accruing  to participants
under the Purchase Plan, if  such approval is required  in order to comply  with
the  requirements of  Rule 16b-3 under  the Exchange  Act or Section  423 of the
Code.
 
    Rights granted before amendment or termination of the Purchase Plan will not
be altered or impaired by any amendment or termination of such plan without  the
consent of the employee to whom such rights were granted.
 
EFFECT OF CERTAIN CORPORATE EVENTS
 
    In  the event of a  dissolution, liquidation or specified  type of merger of
the Company,  then, as  determined by  the  Board in  its sole  discretion,  the
surviving  corporation either will assume the  rights under the Purchase Plan or
substitute similar rights, or the purchase date under any ongoing offering  will
be  accelerated such  that the outstanding  rights may  be exercised immediately
prior to any such event.
 
STOCK SUBJECT TO PURCHASE PLAN
 
    If rights  granted  under  the  Purchase Plan  expire,  lapse  or  otherwise
terminate  without being  exercised, the Common  Stock not  purchased under such
rights again becomes available for issuance under such plan.
 
FEDERAL INCOME TAX INFORMATION
 
    Rights granted under the Purchase Plan are intended to qualify for favorable
federal income tax treatment  associated with rights  granted under an  employee
stock purchase plan which qualifies under provisions of Section 423 of the Code.
 
                                       27
<PAGE>
    A  participant will be taxed on amounts  withheld for the purchase of shares
as if such amounts were  actually received. Other than  this, no income will  be
taxable  to  a participant  until disposition  of the  shares acquired,  and the
method of taxation will depend upon the holding period of the purchased shares.
 
    If the stock is disposed  of at least two years  after the beginning of  the
offering  period and  at least one  year after  the stock is  transferred to the
participant, then the lesser of (a) the  excess of the fair market value of  the
stock  at the time of such disposition over the purchase price or (b) the excess
of the fair market value of the stock as of the beginning of the offering period
over the exercise price (which for this purpose is deemed to be 85% of the  fair
market  value of the stock  as of the beginning of  the offering period) will be
treated as ordinary  income. Any further  gain or any  loss will be  taxed as  a
long-term capital gain or loss. Capital gains currently are generally subject to
lower tax rates than ordinary income. The maximum capital gains rate for federal
income  tax purposes is 28% while the maximum ordinary rate is effectively 39.6%
at the present time.
 
    If the stock is sold or disposed  of before the expiration of either of  the
holding periods described above, then the excess of the fair market value of the
stock  on the purchase date over the  purchase price will be treated as ordinary
income at the time of such disposition,  and the Company may, in the future,  be
required  to withhold income  taxes relating to such  ordinary income from other
payments made to the  participant. The balance  of any gain  will be treated  as
capital  gain. Even  if the stock  is later disposed  of for less  than its fair
market value  on  the purchase  date,  the same  amount  of ordinary  income  is
attributed  to the participant,  and a capital  loss is recognized  equal to the
difference between the sales  price and the  fair market value  of the stock  on
such  purchase  date.  Any capital  gain  or  loss will  be  long  or short-term
depending on whether the stock has been held for more than one year.
 
    There are no federal income tax consequences to the Company by reason of the
grant or exercise of rights under the Purchase Plan. The Company is entitled  to
a  deduction to the extent amounts are taxed as ordinary income to a participant
(subject to the requirement of reasonableness, the provisions of Section  162(m)
of the Code and the satisfaction of a tax reporting obligation).
 
                                   PROPOSAL 6
               RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS
 
    The  Board of  Directors has  selected Ernst  & Young  LLP as  the Company's
independent auditors  for the  fiscal  year ending  December  31, 1996  and  has
further  directed that management  submit the selection  of independent auditors
for ratification by the  stockholders at the Annual  Meeting. Ernst & Young  LLP
has  audited the Company's  financial statements since  the Company's inception.
Representatives of Ernst & Young  LLP are expected to  be present at the  Annual
Meeting, will have an opportunity to make a statement if they so desire and will
be available to respond to appropriate questions.
 
    Stockholder  ratification  of the  selection  of Ernst  &  Young LLP  as the
Company's independent  auditors is  not  required by  the Company's  By-laws  or
otherwise.  However, the Board is submitting the  selection of Ernst & Young LLP
to the stockholders for ratification as a matter of good corporate practice.  If
the stockholders fail to ratify the selection, the Audit Committee and the Board
will  reconsider whether or  not to retain  that firm. Even  if the selection is
ratified, the Audit Committee and the  Board in their discretion may direct  the
appointment  of different  independent auditors at  any time during  the year if
they determine that such a change would be in the best interests of the  Company
and its stockholders.
 
    The  affirmative vote of the holders of  a majority of the shares present in
person or represented by proxy and entitled to and voting at the Annual  Meeting
will be required to ratify the selection of Ernst & Young LLP.
 
    THE BOARD OF DIRECTORS UNANIMOUSLY RECOMMENDS A VOTE IN FAVOR OF PROPOSAL 6.
 
                                       28
<PAGE>
                             SECURITY OWNERSHIP OF
                    CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
 
    The  following table sets forth  certain information regarding the ownership
of the Company's Common Stock as of February 29, 1996 by: (i) each director  and
each  of the four executive officers;  (ii) all executive officers and directors
as a group; and (iii) those stockholders  known by the Company to be  beneficial
owners of more than five percent of the Company's Common Stock.
 
    The  information as to each  person has been furnished  by such persons, and
each person has sole voting power and sole investment power with respect to  all
shares  beneficially owned  by such  persons except  as otherwise  indicated and
subject to community property laws where applicable. Except as set forth  below,
the  address of each named individual is the address of the Company as set forth
herein.
 
<TABLE>
<CAPTION>
                                                                                            NUMBER OF
                                                                                           BENEFICIAL
                                                                                            OWNERSHIP    PERCENT OF
BENEFICIAL OWNER                                                                             SHARES         TOTAL
- - -----------------------------------------------------------------------------------------  -----------  -------------
<S>                                                                                        <C>          <C>
FMR Corp. (2)
  82 Devonshire Street
  Boston, MA 02109.......................................................................      827,900          8.0
Pharmacia AB (3)
  Hans U. Sievertsson
  Frusadaviks Alle 15
  S-171 97 Stockholm, Sweden.............................................................      738,570          7.2
State Street Research & Management Company (4)
  One Financial Center, 30th Floor
  Boston, MA 02111.......................................................................      640,100          6.2
John P. Walker (5).......................................................................      256,784          2.4
Michael J. Ross (6)......................................................................      208,789          2.0
Heinz W. Gschwend (7)....................................................................       81,305        *
Daniel H. Petree (8).....................................................................       48,160        *
Brook H. Byers (9).......................................................................      234,594          2.3
Anthony B. Evnin (10)....................................................................       24,762        *
Vaughn M. Kailian (11)...................................................................        4,092        *
All Directors and Executive Officers as a Group
  (8 Persons)(12)........................................................................    1,597,056         14.9
</TABLE>
 
- - ------------------------
  * Less than 1 percent.
 
 (1) Percentage of beneficial ownership is based on 10,305,939 shares of  Common
     Stock outstanding as of February 29, 1996.
 
 (2)  Based upon  a Schedule  13G filed by  FMR Corp.  reporting such beneficial
     ownership as of December 31, 1995. Includes 773,500 shares of Common  Stock
     beneficially  owned by Fidelity Management & Research Company ("Fidelity"),
     a wholly-owned subsidiary of FMR Corp. and an investment advisor to various
     investment companies. Of such 773,500  shares, 523,500 shares were held  by
     Fidelity  Select  Biotechnology Portfolio  and the  remainder were  held by
     other funds. Edward  C. Johnson  3d of FMR  Corp., through  its control  of
     Fidelity,  and the  funds each  has sole  power to  dispose of  the 773,500
     shares. Fidelity votes such shares under written guidelines established  at
     the direction of the funds' boards of trustees. Also includes 54,400 shares
     of  Common Stock  beneficially owned  by Fidelity  Management Trust Company
     ("FMTC"), a wholly-owned subsidiary of FMR  Corp. and a bank, which  serves
     as  investment manager of certain institutional accounts. Edward C. Johnson
     3d and FMR Corp., through their control of
 
                                       29
<PAGE>
     FMTC, have sole voting and dispositive  power over such 54,400 shares.  Mr.
     Johnson  is the chairman of,  and Ms. Abigail P.  Johnson is a director of,
     FMR Corp. and,  consequently, each may  be deemed to  beneficially own  all
     827,900  shares  of Common  Stock. In  addition, members  of the  Edward C.
     Johnson 3d  family and  trusts for  their benefit  may be  deemed to  be  a
     controlling  group with respect to FMR Corp. and therefore may be deemed to
     beneficially own all 827,900 shares of Common Stock.
 
 (3) Includes  67,142  shares issuable  upon  exercise of  warrants  exercisable
     within 60 days of February 29, 1996. Hans U. Sievertsson, a Director of the
     Company,  is  Vice President  at  Pharmacia AB.  Dr.  Sievertsson disclaims
     beneficial ownership of all shares held by Pharmacia AB.
 
 (4) State Street Research &  Management Company, an investment advisor  ("State
     Street")  has sole voting power with respect  to 624,500 of such shares and
     sole investment power with  respect to all such  shares. State Street is  a
     wholly-owned  subsidiary of Metropolitan Life Insurance Company, which also
     may be  deemed to  beneficially  own such  shares. State  Street  disclaims
     beneficial ownership of all such shares.
 
 (5)  Includes 216,815 shares issuable upon  exercise of options and exercisable
     within 60 days of  February 29, 1996. Also  includes an aggregate of  8,574
     shares  beneficially owned by  Mr. Walker's wife  as trustee of educational
     trusts for his children.
 
 (6) Includes 8,795  shares issuable  upon exercise of  options and  exercisable
     within   60  days  of  February  29,  1996.  Also  includes  45,000  shares
     beneficially owned  by  the Ross  Family  Trust, of  which  Mr. Ross  is  a
     co-trustee.
 
 (7)  Includes 73,974 shares  issuable upon exercise  of options and exercisable
     within 60 days of February 29, 1996.
 
 (8) Includes 47,188 shares issuable upon exercise of options exercisable within
     60 days of February 29, 1996.
 
 (9) Consists of  203,545 shares held  by Kleiner Perkins  Caufield & Byers  VI,
     19,317  shares held by KPCB Founders Fund I, L.P., and 9,597 shares held by
     KPCB VI Founders Fund, L.P. Also includes 758 shares issuable upon exercise
     of a warrant exercisable within 60 days of February 29, 1996. Mr. Byers  is
     a  general partner of each such partnership. Mr. Byers disclaims beneficial
     ownership of the shares held by each such partnership except to the  extent
     of his pro rata interest therein.
 
(10)  Includes 57 shares  beneficially owned collectively  by Venrock Associates
     and Venrock Associates II, L.P., of which Mr. Evnin is a general partner.
 
(11) Consists  of 4,092  shares issuable  upon exercise  of options  exercisable
     within 60 days of February 29, 1996.
 
(12)  Includes an aggregate of 418,764 shares issuable upon exercise of warrants
     and options exercisable within 60 days of February 29, 1996. See  footnotes
     3, 5, 6, 7, 8, 9 and 11.
 
                                       30
<PAGE>
                      EXECUTIVE OFFICERS AND KEY EMPLOYEES
 
    Set  forth  below  is  information  regarding  executive  officers  and  key
employees of the Company as of March 21, 1996.
 
<TABLE>
<CAPTION>
             NAME                   AGE                              POSITION WITH THE COMPANY
- - -------------------------------     ---     ---------------------------------------------------------------------------
<S>                              <C>        <C>
John P. Walker                      47      President, Chief Executive Officer and Director
Michael J. Ross, Ph.D.              46      Executive Vice President, Chief Technical Officer and Director
Heinz W. Gschwend, Ph.D.            59      Vice President, Research and Development
Daniel H. Petree                    40      Vice President, Corporate Development and Chief Financial Officer
Michael C. Venuti, Ph.D.            42      Vice President, Research Technology
Natalie J. Warner, M.D.             47      Vice President, Medical Affairs
Alan C. Mendelson                   47      Secretary
</TABLE>
 
- - ------------------------
 
    John P. Walker has been President, Chief Executive Officer and a Director of
the Company since February 1993. From 1991 to 1993, he was a venture  capitalist
at  Alpha Venture Partners. Prior  to that time, he  was Chairman, President and
Chief Executive Officer of Vitaphore  Corporation, a company which was  acquired
in  April 1990 by  Union Carbide Chemicals and  Plastics Company, Inc. Following
that acquisition,  Mr. Walker  served as  the latter  company's Vice  President,
Biomaterials  Systems. From  1971 to 1985,  Mr. Walker was  employed by American
Hospital Supply  Corporation  in a  variety  of general  management,  sales  and
marketing positions, most recently serving as President of the American Hospital
Company.  He received his B.A.  degree from the State  University of New York at
Buffalo and  conducted  graduate  business studies  at  Northwestern  University
Institute  for Management.  Mr. Walker serves  as a director  of several private
companies.
 
    Michael J. Ross, Ph.D. has been Executive Vice President and Chief Technical
Officer of the Company since  February 1993 and a  Director since he joined  the
Company in September 1990 as President and Chief Executive Officer. From 1978 to
1990,  he was employed by Genentech, Inc., a biopharmaceutical company, where he
most recently was Vice President,  Medicinal and Biomolecular Chemistry and  was
responsible  for building  that company's  small molecule  discovery effort. Dr.
Ross received a Ph.D. in chemistry  from the California Institute of  Technology
and held a postdoctoral fellowship in molecular biology at Harvard University.
 
    Heinz W. Gschwend, Ph.D. has been Vice President of Chemistry of the Company
since  January 1992  and was named  Vice President, Research  and Development in
September 1993.  Prior  to  that time,  he  was  Head of  the  Central  Research
Laboratories  of Ciba-Geigy  Ltd., a  multinational chemical  and pharmaceutical
company, in Basel,  Switzerland. An  employee of  Ciba-Geigy Corporation  (U.S.)
since  1967, Dr. Gschwend has also held  the senior management positions of Vice
President, Drug Discovery  and Vice  President, Cardiovascular/  Atherosclerosis
Research  (U.S.).  Dr.  Gschwend  received  his  Ph.D.  from  the  Swiss Federal
Institute of  Technology  (ETH)  and  conducted  postdoctoral  studies  at  that
institution and at Harvard University.
 
    Daniel  H. Petree has been Vice President of Corporate Development and Chief
Financial Officer of the Company  since August 1993. From  1992 to 1993, he  was
Vice President, Business Development of TSI Corporation, a biotechnology service
company.  Prior to that  time, he was with  Montgomery Securities, an investment
banking firm, from 1987  to 1992, ultimately serving  as Vice President,  Health
Care  Group in Montgomery's  corporate finance division. From  1983 to 1987, Mr.
Petree was  a corporate  attorney in  the  offices of  Heller, Ehrman,  White  &
McAuliffe.  Mr. Petree received his J.D.  degree from the University of Michigan
Law School and holds a B.A. degree from Stanford University.
 
    Michael C. Venuti, Ph.D., has been Vice President, Research Technology since
November 1994. Prior  to that he  was at Parnassus  Pharmaceuticals, a  start-up
biotechnology  company where he was Vice President, Chief Scientific Officer and
a founder. From 1988 to 1993, Dr. Venuti was at
 
                                       31
<PAGE>
Genentech, where he  was Director  of Bioorganic  Chemistry, a  program that  he
helped  establish. Previously, he was  with Syntex Corporation, a pharmaceutical
company, as a section head at the Institute of Bioorganic Chemistry. Dr.  Venuti
received  his A.B.  in chemistry  from Dartmouth College  in 1975,  his Ph.D. in
organic chemistry in 1979 from the Massachusetts Institute of Technology and was
a postdoctoral fellow at the Syntex Institute of Organic Chemistry.
 
    Natalie Jean Warner, M.D., joined Arris  in December 1995 as Vice  President
of Medical Affairs directly from Khepri, where she was Vice President of Medical
Affairs  and  Drug Development.  Prior to  Khepri, Dr.  Warner worked  at Syntex
Corporation (1988-1993), where  she held  a number of  positions, most  recently
Vice  President, Worldwide Safety  Surveillance and Reporting.  She has 11 years
experience in clinical  research and  regulatory affairs at  Khepri, Syntex  and
Merck, Sharp and Dohme (1984-1988) and has worked on a number of successful NDAs
and worldwide marketing applications. She completed her fellowship and residency
at  Columbia University. She  holds an M.D.  from Cornell Medical  College and a
B.A. from Swathmore College.
 
    Alan C. Mendelson has served as Secretary  of the Company from July 1993  to
present,  with the exception of several months in 1994. He has been a partner of
Cooley Godward Castro Huddleson & Tatum, a  private law firm and counsel to  the
Company,  since 1980 and served as the  managing partner of its Palo Alto office
from May 1990  through March 1995.  Mr. Mendelson also  served as Secretary  and
Acting General Counsel of Amgen, a biopharmaceutical company, from April 1990 to
March  1991 and has served as Acting  General Counsel of Cadence Design Systems,
Inc., an electronic design automation software company, since November 1995. Mr.
Mendelson is currently a director of Acuson Corporation, CoCensys, Inc., Elexsys
International, Inc. and Isis Pharmaceuticals, Inc. Mr. Mendelson received a J.D.
from Harvard University in 1973.
 
COMPLIANCE WITH THE REPORTING REQUIREMENTS OF SECTION 16(A)
 
    Section 16(a)  of the  Securities  Exchange Act  of  1934 (the  "1934  Act")
requires  the Company's  directors and executive  officers, and  persons who own
more than ten percent of a registered class of the Company's equity  securities,
to  file with  the SEC initial  reports of  ownership and reports  of changes in
ownership of Common Stock and other equity securities of the Company.  Officers,
directors  and  greater  than  ten  percent  stockholders  are  required  by SEC
regulation to furnish the  Company with copies of  all Section 16(a) forms  they
file.
 
    To  the Company's knowledge, based solely on  a review of the copies of such
reports furnished  to the  Company  and written  representations that  no  other
reports  were  required, during  the fiscal  year ended  December 31,  1995, all
Section 16(a)  filing requirements  applicable to  its officers,  directors  and
greater than ten percent beneficial owners were complied with.
 
                             EXECUTIVE COMPENSATION
 
COMPENSATION OF DIRECTORS
 
    The  Company's directors do not currently  receive any cash compensation for
service of the Board or any  committee thereof, but directors may be  reimbursed
for  certain  expenses  incurred  in connection  with  attendance  at  Board and
Committee Meetings.
 
    Each non-employee director of the Company also receives stock option  grants
under  the  1994  Non-Employee  Directors' Stock  Option  Plan  (the "Directors'
Plan"). Only  non-employee directors  of the  Company or  an affiliate  of  such
directors  (as defined in  the Code) are  eligible to receive  options under the
Directors' Plan. Options granted under the  Directors' Plan are intended by  the
Company not to qualify as incentive stock options under the Code.
 
    Option  grants under the Directors'  Plan are non-discretionary. Pursuant to
the terms of the Directors' Plan, each person elected for the first time to be a
non-employee director of the Company will automatically be granted an option  to
purchase  15,000 shares  of Common  Stock upon  the date  of his  or her initial
election as a  non-employee director  by the Board  or the  Stockholders of  the
Company.  On  the  date of  the  Annual  Meeting of  Stockholders  of  each year
beginning in 1995, each member of the
 
                                       32
<PAGE>
Company's Board  of Directors  who is  not an  employee of  the Company  (or  an
affiliate  of such director  where specified by  the non-employee director), and
has  served  as  a  non-employee  director   for  at  least  three  months,   is
automatically  granted under the Directors' Plan,  without further action by the
Company, the Board of Directors or the stockholders of the Company, an option to
purchase 2,500 shares of Common  Stock of the Company.  No other options may  be
granted  at any time  under the Directors'  Plan. The exercise  price of options
granted under the Directors' Plan is 100% of the fair market value of the Common
Stock subject to the  option on the  date of the  option grant. Options  granted
under  the Directors' Plan may  not be exercised until  the date upon which such
optionee, or the affiliate of  such optionee, as the  case may be, has  provided
one  year of continuous service as a non-employee director following the date of
grant of such option, whereupon such  option shall become exercisable as to  25%
of  the option shares and 25% of the option shares shall become exercisable each
year thereafter in accordance with it  terms. The term of options granted  under
the  Directors' Plan is ten years. In the  event of a merger of the Company with
or into another corporation or a  consolidation, acquisition of assets or  other
change-in-control  transaction involving the Company, the vesting of each option
will accelerate and  the option will  terminate if not  exercised prior to  such
event.
 
    During  the last  fiscal year,  the Company  granted options  covering 2,500
shares to each non-employee  Director of the Company,  at an exercise price  per
share of $8.06, which was the fair market value of the stock as of June 7, 1995,
the  date of grant. In addition, during the last fiscal year the Company granted
options covering 15,000 shares to one non-employee Director of the Company  upon
his  election as a Director, at an exercise  price of $10.15, which was the fair
market value of the stock as of December 22, 1995, the date of grant. Arris also
assumed options that had been  granted to Mr. Kailian  by Khepri in April  1995,
which  effective December 22, 1995, were  converted to options to purchase 4,092
shares of Arris  Common Stock at  an exercise price  of $2.45 per  share. As  of
February 29, 1996, no options had been exercised under the Directors' Plan.
 
COMPENSATION OF EXECUTIVE OFFICERS
 
    The following table shows for the fiscal years ended December 31, 1995, 1994
and  1993, compensation awarded  or paid to,  or earned by,  the Company's Chief
Executive Officer and  its other executive  officers at December  31, 1995  (the
"Named Executive Officers"):
 
                           SUMMARY COMPENSATION TABLE
 
<TABLE>
<CAPTION>
                                                                                             LONG-TERM COMPENSATION
                                                                                                     AWARDS
                                                             ANNUAL COMPENSATION          ----------------------------
                                                     -----------------------------------  SECURITIES
                                                                           OTHER ANNUAL   UNDERLYING      ALL OTHER
                                                      SALARY      BONUS    COMPENSATION    OPTIONS/     COMPENSATION
      NAME AND PRINCIPAL POSITION           YEAR        ($)        ($)          ($)        SARS (#)        ($)(1)
- - ----------------------------------------  ---------  ---------  ---------  -------------  -----------  ---------------
<S>                                       <C>        <C>        <C>        <C>            <C>          <C>
                                               1995    265,000     75,000       --           100,000            696
John P. Walker .........................       1994    245,000     62,475       --            --                667
 President and Chief Executive Officer         1993    206,250     56,000       --           260,714            638
Michael J. Ross, Ph.D. .................       1995    208,400     31,385       --            45,000            696
 Executive Vice President and Chief            1994    193,000     31,210       --            --                696
 Technical Officer (2)(3)                      1993    173,750     34,200       --            28,571          5,265
Heinz W. Gschwend, Ph.D ................       1995    191,200     29,254       --            45,000          1,800
 Vice President, Research and                  1994    177,000     30,090       --            15,000          1,725
 Development, Inflammation                     1993    165,000     31,350       --            14,285            810
Daniel H. Petree .......................       1995    156,500     26,622       12,903(4)     45,000            391
 Vice President, Corporate Development         1994    145,000     24,650       17,727(4)     15,000            264
 and Chief Financial Officer                   1993     58,518     13,500       29,523(4)     50,000            110
</TABLE>
 
- - ------------------------
(1) Consists of life insurance premiums paid.
 
                                       33
<PAGE>
(2)  Prior to 1993,  Dr. Ross was  President, Chief Executive  Officer and Chief
    Financial Officer of  the Company.  He became Executive  Vice President  and
    Chief Technical Officer in February 1993.
 
(3)  Dr. Ross was granted  the right to purchase  125,713 shares of Common Stock
    prior to 1993, which shares were purchased  at the market value on the  date
    of  purchase.  The shares  purchased  vest over  a  four-year period.  As of
    December 31, 1995, the aggregate value  of these restricted shares would  be
    $1,697,126 based on the fair market value of $13.50 per share at such date.
 
(4)  Consists of  payments to  Mr. Petree in  connection with  his relocation to
    California.
 
STOCK OPTION GRANTS AND EXERCISES
 
    The Company grants options to its executive officers under its 1989 Plan. As
of February 29, 1996, options to purchase  a total of 2,297,273 shares had  been
granted  under  the  1989  Plan,  and no  shares  remained  available  for grant
thereunder. Certain  additional information  concerning options  granted to  the
Named  Executive Officers since January 1, 1996  are set forth above in the "New
Plan Benefits" table. See Proposal 4.
 
    The following tables  show for  the year  ended December  31, 1995,  certain
information  regarding options granted to, exercised by  and held at year end by
the Named Executive Officers:
 
                       OPTION GRANTS IN FISCAL YEAR 1995
 
<TABLE>
<CAPTION>
                                                                                                 POTENTIAL REALIZABLE
                                                          INDIVIDUAL GRANTS                        VALUE AT ASSUMED
                                                   --------------------------------                ANNUAL RATES OF
                                     NUMBER OF        % OF TOTAL                                     STOCK PRICE
                                     SECURITIES         OPTIONS                                    APPRECIATION FOR
                                     UNDERLYING       GRANTED TO       EXERCISE OR                 OPTION TERM (3)
                                      OPTIONS        EMPLOYEES IN      BASE PRICE    EXPIRATION  --------------------
NAME                               GRANTED (#)(1)   FISCAL YEAR (2)      ($/SH)         DATE      5% ($)     10% ($)
- - ---------------------------------  --------------  -----------------  -------------  ----------  ---------  ---------
<S>                                <C>             <C>                <C>            <C>         <C>        <C>
John P. Walker...................        50,000              8.1             6.20      01/12/05    194,957    494,060
                                         50,000              8.1             8.06      06/06/05    253,445    642,278
Michael J. Ross, Ph.D............        25,000              4.1             6.90      03/27/05    108,484    274,921
                                         20,000              3.2             8.06      06/06/05    101,377    256,911
Heinz W. Gschwend, Ph.D..........        25,000              4.1             6.90      03/27/05    108,484    274,921
                                         20,000              3.2             8.06      06/06/05    101,377    256,911
Daniel H. Petree.................        25,000              4.1             6.90      03/22/05    108,484    274,921
                                         20,000              3.2             8.06      06/06/05    101,377    256,911
</TABLE>
 
- - ------------------------
(1) Options granted in January and March 1995 become exercisable with respect to
    1/8 of the  number of underlying  shares on the  6-month anniversary of  the
    grant  and at a rate  of 1/48 of such  options per month thereafter. Options
    granted in June 1995 become exercisable on  June 7, 2005 if the optionee  is
    continuously  employed through such  date; provided, however,  that all or a
    portion of these options may become exercisable no sooner than June 7,  1998
    upon  the price of  the Company's Common Stock  attaining certain levels and
    the Company meeting performance goals determined by the Board of  Directors,
    provided that the optionee continues to remain employed through such date.
 
(2) Based on options to purchase 617,175 shares granted in 1995.
 
(3)  The potential realizable  value is based on  the term of  the option at its
    time of grant (10 years). It is calculated by assuming that the stock  price
    on  the date of  grant appreciates at the  indicated annual rate, compounded
    annually for the entire term of the option and that the option is  exercised
    and sold on the last day of its term for the appreciated stock price.
 
                                       34
<PAGE>
                AGGREGATED OPTION EXERCISES IN FISCAL YEAR 1995
                       AND FISCAL YEAR-END OPTION VALUES
 
<TABLE>
<CAPTION>
                                                                                NUMBER OF
                                                                               SECURITIES
                                                                               UNDERLYING         VALUE OF UNEXERCISED
                                                                           UNEXERCISED OPTIONS    IN-THE-MONEY OPTIONS
                                                                              AT FY-END (#)          AT FY-END ($)
                                           SHARES ACQUIRED       VALUE        EXERCISABLE/            EXERCISABLE/
NAME                                       ON EXERCISE (#)     REALIZED       UNEXERCISABLE        UNEXERCISABLE (1)
- - ---------------------------------------  -------------------  -----------  -------------------  ------------------------
<S>                                      <C>                  <C>          <C>                  <C>
John P. Walker.........................          --               --         190,922/169,792      2,278,658/1,506,482
Michael J. Ross, Ph.D..................          --               --          23,736/49,835         264,088/359,421
Heinz W. Gschwend, Ph.D................          --               --          67,574/56,711         821,317/396,731
Daniel H. Petree.......................          --               --          38,855/71,145         380,328/540,372
</TABLE>
 
- - ------------------------
(1)  Based on the fair market value of  the Common Stock as of December 31, 1995
    ($13.50), minus  the exercise  price,  multiplied by  the number  of  shares
    underlying the option.
 
EMPLOYMENT AGREEMENT
 
    In  August 1990, the  Company entered into an  employment agreement with Dr.
Michael J. Ross, which provides for the  employment of Dr. Ross as an  executive
officer  of the Company. The  agreement provides that if  Dr. Ross is terminated
other than for cause, he is entitled to monthly installments of $10,000 for each
of the  first three  months following  termination or  until he  is  reemployed,
whichever  occurs  first.  The  agreement further  provides  that  the  Board of
Directors will either vote or recommend to the stockholders of the Company, that
Dr. Ross be nominated for election as a director of the Company during his  term
of  employment. The  agreement is  terminable at  will upon  delivery of written
notice.
 
COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION
 
    From January 1 through  June 7, 1995,  the Company's Compensation  Committee
was  composed of Brook H.  Byers and James M. Garvey.  From June 7, 1995 through
the close of the fiscal year,  the Compensation Committee was composed of  Brook
H.  Byers and Anthony B. Evnin. None of Messrs. Byers, Garvey or Evnin is or has
been an officer or employee of the Company.
 
                                       35
<PAGE>
         REPORT OF THE COMPENSATION COMMITTEE OF THE BOARD OF DIRECTORS
                         ON EXECUTIVE COMPENSATION (1)
 
GENERAL
 
    From  January 1 to June 7, 1995, the Compensation Committee was comprised of
Brook H. Byers and James M. Garvey. In June 1995, Mr. Garvey was replaced on the
Compensation Committee by Anthony B. Evnin.
 
COMPENSATION PHILOSOPHY
 
    The primary goal of the Company is to align compensation with the  Company's
business objectives and performance. The Company's aim is to attract, retain and
reward  executive officers and  other employees who  contribute to the long-term
success of the Company  and to motivate those  individuals to enhance  long-term
stockholder value. To establish this relationship between executive compensation
and  the creation  of stockholder  value, the Board  of Directors  has adopted a
total compensation package comprised of base salary, bonus and stock option  and
stock grant awards. Key elements of this compensation package are:
 
    - The  Company  pays salaries  at least  competitive  with those  of leading
      biotechnology and pharmaceutical companies with which the Company competes
      for talent.
 
    - The Company  maintains incentive  opportunities designed  to motivate  and
      reward   achievement  of  specific  Company   and  individual  goals.  The
      availability  of  these  incentives  is   designed  to  bring  the   total
      compensation for key employees to competitive levels within the industry.
 
    - The  Company provides  significant equity-based  incentives for executives
      and other key employees to ensure that individuals are motivated over  the
      long   term  to   respond  to   the  Company's   business  challenges  and
      opportunities as owners and not just as employees.
 
SALARY
 
    The salary compensation for all employees, including executive officers,  is
based  upon a matrix that plots the base compensation of an employee against the
compensation of  employees  in  similar positions  in  other  biotechnology  and
pharmaceutical  companies, in accordance with a published survey of the employee
compensation of such companies. Base salaries are targeted at the upper quartile
for  comparable  positions  in  the  other  companies  in  the  matrix.   Salary
adjustments  for 1995  were based on  each individual's  performance ranking. In
establishing base  salaries  for the  executive  officers, the  Board  carefully
reviewed  the  progress made  in the  programs  headed by  each officer  and the
dependence of the  Company on  these officers  for the  scientific and  business
development  of  their respective  programs.  The Board  also  considered salary
information of other biotechnology and pharmaceutical corporations.
 
ANNUAL INCENTIVE COMPENSATION
 
    A portion of the cash compensation paid to the Company's executive officers,
including the Chief  Executive Officer, is  in the form  of discretionary  bonus
payments  that are paid on  an annual basis, as  part of the Company's Incentive
Bonus Plan.  Bonus payments  are expressly  linked to  the attainment  of  goals
established  for each executive officer, as well as overall corporate goals, and
are limited by the  target bonus pool  established for each  officer which is  a
percentage  of  the  officer's  base salary.  General  corporate  goals  in 1995
included the establishment of collaborative partnering arrangements in key areas
of  research,  the  continuation  of  clinical  development  of  the   Company's
compounds,  research milestones in each of the Company's discovery programs, and
strengthening of the Company's balance sheet.
 
- - ------------------------
(1) The material  in this  report is not  "soliciting material,"  is not  deemed
    filed  with the SEC and is not to be incorporated by reference in any filing
    of the Company under the Securities Act of 1933 as amended (the  "Securities
    Act") or the Exchange Act.
 
                                       36
<PAGE>
    In  awarding discretionary bonuses  to the officers,  the Board of Directors
believed  that  both  corporate   and  individual  goals   for  the  year   were
substantially attained. Accordingly, the officers, including the Chief Executive
Officer, were awarded substantially all of their individual bonus potential.
 
LONG-TERM INCENTIVES
 
    The  Company's primary long-term incentive program presently consists of the
1989 Plan  and  the  Purchase  Plan. The  1989  Plan  utilizes  vesting  periods
(generally  four years) to encourage key employees  to continue in the employ of
the Company.  Through  option  grants,  executives  receive  significant  equity
incentives  to build long-term stockholder value.  The exercise price of options
granted under the 1989 Plan  generally is 100% of the  fair market value of  the
underlying stock on the date of grant. Employees receive value from these grants
only if the Company's Common Stock appreciates in the long term.
 
    The  Company established  the Purchase Plan  both to  encourage employees to
continue in  the employ  of the  Company and  to motivate  employees through  an
ownership interest in the Company. Under the Purchase Plan, employees, including
officers,  may have up to 10% of their earnings withheld for purchases of Common
Stock on  certain  dates specified  by  the Board.  The  price of  Common  Stock
purchased  will be equal  to 85% of  the lower of  the fair market  value of the
Common Stock  on the  date of  commencement of  participation in  each  24-month
offering period or on each specified purchase date.
 
    In  June 1995, the Board  of Directors granted stock  options to four of the
continuing executive officers. The grant of  the options was based on the  prior
performance  of each executive officer and the  need to retain these officers in
light of the increasing demands  placed upon them as  a result of the  Company's
growth.  In  this regard,  the Board  was  mindful of,  among other  things, the
success of  these  officers,  which  was evidenced  by  the  completion  of  the
Company's  collaboration agreements with Pharmacia AB, which the Company entered
into in August  1995, and  the acquisition  of Khepri  Pharmaceuticals, Inc.  in
December  1995. In reaching  its decisions, the Board  relied on its experience,
information gained  in  the hiring  process,  and  the value  of  the  executive
officer's previously issued stock options.
 
COMPANY PERFORMANCE AND CHIEF EXECUTIVE OFFICER COMPENSATION
 
    The Chief Executive Officer joined the Company in February 1993. His initial
salary,  potential bonus and stock option grants were determined on the basis of
negotiations between the Board of Directors and the Chief Executive Officer with
due  regard  to  his  experience,  competitive  salary  information  and  market
conditions  at the time.  Mr. Walker's 1995  salary was set  by the Compensation
Committee. As with  the other  executive officers,  the amount  of Mr.  Walker's
total compensation was based on the Company's 1995 accomplishments and the Chief
Executive  Officer's  significant contribution  thereto, including,  among other
things, performance to plan, the completion of the collaboration agreement  with
Pharmacia  AB in August 1995 and the acquisition of Khepri Pharmaceuticals, Inc.
in December 1995.
 
CERTAIN TAX CONSIDERATIONS
 
    Section 162(m) of the Internal Revenue Code (the "Code") limits the  Company
to  a deduction for federal  income tax purposes of not  more than $1 million of
compensation paid to certain executive officers in a taxable year.  Compensation
above  $1  million may  be deducted  if  it is  "performance-based compensation"
within the meaning of the Code.
 
                                       37
<PAGE>
    The Compensation Committee has determined  that stock options granted  under
the  1989 Plan with an exercise price at least equal to the fair market value of
the  Company's  common  stock  on  the  date  of  grant  should  be  treated  as
"performance-based   compensation."  To   achieve  this  result,   in  1995  the
stockholders approved a per-employee, per-year  limitation on the size of  stock
option grants.
 
    From  the  members of  the  Compensation Committee  of  Arris Pharmaceutical
Corporation:
 
       Brook H. Byers
       Anthony B. Evnin, Ph.D.
 
                     PERFORMANCE MEASUREMENT COMPARISON (1)
 
    The following chart shows the value of an investment of $100 in cash of  (i)
the  Company's Common Stock, (ii) the Nasdaq  Stock Market -- US Index and (iii)
the AMEX Biotechnology Index. All values assume reinvestment of the full  amount
of all dividends*:
 
EDGAR REPRESENTATION OF DATA POINTS USED IN PRINTED GRAPHIC
 
<TABLE>
<CAPTION>
              ARRIS PHARMACEUTICAL         NASDAQ STOCK MARKET - US          AMEX BIOTECHNOLOGY
<S>        <C>                          <C>                              <C>
Nov93                           100.00                           100.00                      100.00
Dec93                            90.74                            99.72                       91.76
Dec94                            96.30                            97.48                       65.03
Dec95                           200.00                           137.85                      106.02
</TABLE>
 
*  $100  invested on November 19, 1993 in Common Stock of Arris (the date of the
   Company's initial public  offering) or on  October 31, 1993  in the  indices,
   including reinvestment of dividends. Fiscal year ending December 31.
 
- - ------------------------
(1)  This Section is not "soliciting material," is not deemed filed with the SEC
    and is not  to be incorporated  by reference  in any filing  of the  Company
    under the Securities Act or the Exchange Act.
 
                                       38
<PAGE>
                 CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
 
    In  August  1995,  the  Company  entered  into  a  research  and development
agreement with Pharmacia & Upjohn, a  5% stockholder of the Company, focused  on
the  development of inhibitors of Thrombin, Factor  Xa and Factor VIIa using the
Company's technology, for the  treatment of blood  clotting disorders. In  March
1996  the Company entered into an  additional research and development agreement
with Pharmacia & Upjohn, pursuant to which the Company will share with Pharmacia
& Upjohn certain of  its compound libraries and  technologies for synthesis  and
screening  in exchange for license fees and milestone payments. During 1995, the
Company received an aggregate of $9,574,000 from Pharmacia & Upjohn relating  to
commitment  fees  and  research  funding  and  support  under  new  and existing
collaborative agreements with the Company.  The Company paid Pharmacia &  Upjohn
approximately  $389,000 for routine purchases of materials and supplies. Hans U.
Sievertsson, a director  of the Company,  is Vice President  of Pharmacia AB,  a
unit of Pharmacia & Upjohn.
 
    In   December  1995,  the  Company  acquired  Khepri  Pharmaceuticals,  Inc.
("Khepri") in a stock-for-stock merger (the "Merger"). Brook Byers, a member  of
the  Board  of Directors  of  Arris, is  a  general partner  of  Kleiner Perkins
Caufield & Byers, which, together with its affiliates, owned approximately 17.2%
of the outstanding capital stock  of Khepri prior to  the Merger. Mr. Byers  did
not  participate  in  the  negotiation  of the  Merger  or  the  Arris  Board of
Directors' consideration or approval of the Merger. See Proposal 2 --  "Interest
of Certain Parties".
 
    In  March 1993, the Company loaned $200,000 to John P. Walker, the Company's
President and Chief  Executive Officer, to  purchase 31,475 shares  of Series  D
Preferred  Stock. The  loan is  full-recourse and  secured by  the shares, bears
interest at the rate of 7% per annum and is due in February 1999. As of February
29, 1996,  principal  and  interest  in an  aggregate  amount  of  $240,000  was
outstanding  on the  loan. Since January  1, 1995, the  largest aggregate amount
outstanding on the loan  was $240,000. The Company  believes that the  foregoing
transaction was in its best interests.
 
    The  Company  has  entered into  an  employment  agreement with  one  of its
officers. See "Executive Compensation."
 
    The Company's Bylaws provide that  the Company will indemnify its  directors
and  executive officers and may identify its other officers, employees and other
agents to the  fullest extent  permitted by Delaware  law. The  Company is  also
empowered  under its  Bylaws to  enter into  indemnification contracts  with its
directors and officers and to purchase insurance  on behalf of and person it  is
required  or permitted to indemnify. Pursuant to this provision, the Company has
entered into indemnity agreements with each of its directors and officers.
 
                                       39
<PAGE>
                INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE
 
    Financial statements for Khepri  for the years ended  December 31, 1994  and
1993,  and for the period  from inception (April 24,  1992) through December 31,
1992, together  with the  report  of Ernst  &  Young LLP,  Khepri's  independent
auditors,  are incorporated  by reference from  the Company's  Current Report on
Form 8-K (File No. 0-22788), dated December 22, 1995, filed January 5, 1996, and
amended February 5, 1996.
 
    Unaudited pro  forma financial  statements for  the combined  operations  of
Arris  and Khepri  for the  year ended  December 31,  1995, are  incorporated by
reference from the Company's Current Report  on Form 8-K (File No. 0-22788),  as
amended, dated December 22, 1995, filed January 5, 1996, and amended February 5,
1996.
 
    Arris' Annual Report on Form 10-K for the year ended December 31, 1995 (File
No. 0-22788), filed March 14, 1996, is incorporated by reference herein. Certain
financial  information  from  the  Form  10-K  and  management's  discussion and
analysis of this information  is included in the  Annual Report to  Stockholders
being mailed concurrently with this Proxy Statement.
 
    Arris'  Registration Statement on Form 8-A (File No. 0-22788), as filed with
the Securities and Exchange Commission on  November 4, 1993, is incorporated  by
reference herein.
 
    All  documents filed by the Company pursuant to sections 13(a), 13(c), 14 or
15(d) of the Securities Exchange Act of 1934, as amended, after the mailing date
of this  proxy statement  and prior  to June  5, 1996,  the date  of the  Annual
Meeting, shall be deemed to be incorporated by reference herein and to be a part
hereof  from the date  of filing of  such documents. Any  statement contained in
this proxy statement or in a document incorporated or deemed to be  incorporated
by reference herein shall be deemed to be modified or superseded for purposes of
this  Proxy Statement to the extent that  a statement contained herein or in any
subsequently-filed document which  also is or  is deemed to  be incorporated  by
reference  herein modifies or  superseded such statement.  Any such statement so
modified or  superseded shall  not  be deemed,  as  modified or  superseded,  to
constitute a part of this Proxy Statement.
 
                                 OTHER MATTERS
 
    The  Board of Directors knows of no other matters that will be presented for
consideration at the Annual Meeting. If  any other matters are properly  brought
before the meeting, it is the intention of the persons named in the accompanying
proxy to vote on such matters in accordance with their best judgment.
 
                                          By Order of the Board of Directors
 
                                          Daniel H. Petree
                                          ASSISTANT SECRETARY
 
   
May 8, 1996
    
 
                                       40
<PAGE>

- - -------------------------------------------------------------------------------

                        ARRIS PHARMACEUTICAL CORPORATION


                      PROXY SOLICITED BY BOARD OF DIRECTORS
                       FOR THE ANNUAL MEETING JUNE 5, 1996

      John P. Walker and Daniel H. Petree, or either of them, each with power of
substitution, hereby are authorized to represent and vote as designated on the
reverse side the shares of the undersigned at the Annual Meeting of Stockholders
of Arris Pharmaceutical Corporation to be held Wednesday, June 5, 1996, at
8:00 a.m. local time, at the Company's offices located at 385 Oyster Point
Boulevard, Suite 3, South San Francisco, California, or at any adjournment of
the Annual Meeting.

      Shares represented by this proxy will be voted as directed by the
stockholder. If no such directions are indicated, the proxies will have
authority to vote FOR the Election of Directors and FOR Proposals 2 through 6.

- - -------------------------------------------------------------------------------
                            * FOLD AND DETACH HERE *

<PAGE>
- - -------------------------------------------------------------------------------
                       PLEASE MARK, DATE, SIGN AND RETURN.

                                                       Please mark
                                                       your votes as  /X/
                                                       indicated in
                                                       this example




                              FOR all             WITHHOLD AUTHORITY
                              nominees            to vote for all nominees
                              listed below.       listed below.

1. Election of                     / /                 / /
   Directors

Authority to vote for any nominee may be withheld by lining through such
nominee's name below.

John P. Walker, Michael J. Ross, Ph.D., Brook H. Byers, Anthony B. Evnin, Ph.D.,
Vaughn M. Kailian, Hans U. Sievertsson, Ph.D.

                                                  FOR  AGAINST   ABSTAIN

2. To approve the issuance of a sufficient        / /    / /       / /
   number of shares to satisfy the payment
   of the Second Stock Payment, pursuant to
   the Company's recent acquisition of Khepri
   Pharmaceuticals, Inc. ("Khepri").

3. To approve the issuance of a sufficient        / /    / /       / /
   number of shares to satisfy the exercise
   of certain exchange rights of the Class B
   Shareholders of Khepri Pharmaceuticals
   Canada, Inc.

4. To approve the Company's 1989 Stock Plan,     / /     / /       / /
   as amended, to increase the aggregate
   number of shares of Common Stock authorized
   for issuance under such plan by 550,000
   shares, to 2,667,500 shares.

5. To approve the Company's Employee Stock       / /     / /       / /
   Purchase Plan, as amended, to increase the
   number of shares of Common Stock authorized
   for issuance under such plan by 100,000
   shares, to 250,000 shares.

6. To ratify the selection of Ernst & Young      / /     / /       / /
   LLP as independent auditors of the Company
   for its fiscal year ending December 31,
   1996.

7. To transact such other business as may        / /     / /       / /
   properly come before the meeting or any
   adjournment or postponement thereof.

   THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE ELECTION OF DIRECTORS AND
   FOR PROPOSALS 2 THROUGH 6.


SIGNATURE(s)                                      DATED                 ,1996
            --------------------------------             --------------
PLEASE SIGN EXACTLY AS YOUR NAME APPEARS ON THIS PROXY. IF SIGNING FOR ESTATES,
TRUSTS OR CORPORATIONS, TITLE OR CAPACITY SHOULD BE STATED. IF SHARES ARE HELD
JOINTLY, EACH HOLDER SHOULD BE STATED. IF SHARES ARE HELD JOINTLY, EACH HOLDER
SHOULD SIGN.
- - -------------------------------------------------------------------------------
                           * FOLD AND DETACH HERE *


<PAGE>

                                                                  EXHIBIT 23.1

               CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS

We consent to the incorporation by reference in the Proxy Statement of Arris 
Pharmaceutical Corporation of our reports dated April 8, 1994 and March 31, 
1995, with respect to the financial statements of Khepri Pharmaceuticals, 
Inc. included in the Arris' Current Report on Form 8-K filed January 5, 1996, 
as amended by Amendment No. 1 on Form 8-K/A dated February 2, 1996, filed with 
the Securities and Exchange Commission.

                                        /s/ Ernst & Young LLP


Palo Alto, California
May 2, 1996



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