ARRIS PHARMACEUTICAL CORP/DE/
10-Q, 1996-11-14
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            WASHINGTON, D.C. 20549

                                   FORM 10-Q
                                           
[ X ]  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
       EXCHANGE ACT OF 1934

              For the quarterly period ended September 30, 1996

                                       OR   
                                           
[   ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
       EXCHANGE ACT OF 1934

For the transition period from ____________ to ____________ .

                        Commission File Number: 0-22788
                                           
                       ARRIS PHARMACEUTICAL CORPORATION
             (Exact name of registrant as specified in its charter)
                                           
DELAWARE                                                              22-2969941
- --------                                                              ----------
(State or other jurisdiction of                (IRS Employer Identification No.)
incorporation or  organization)

                              385 OYSTER POINT BOULEVARD
                        SOUTH SAN FRANCISCO, CALIFORNIA 94080
                       (Address of principal executive offices)
                                           
                                    (415) 829-1000
                 (Registrant's telephone number, including area code)
                                           
Indicate by check mark whether the registrant (1) has filed all reports required
by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the
preceding 12 months (or for such shorter period that the registrant was required
to file such reports), and (2) has been subject to such filing requirements for
the past 90 days. 
 [x] Yes  [  ] No 

The number of outstanding shares of the registrant's Common Stock, $0.001 par
value, was 14,274,985 as of October 31, 1996. 


                                       1

<PAGE>

                        ARRIS PHARMACEUTICAL CORPORATION
                                           
                                     INDEX
                                           

                                                                            PAGE
PART I:  FINANCIAL INFORMATION

ITEM 1.    Financial Statements (unaudited) *

Consolidated Balance Sheets - September 30, 1996 and December 31, 1995 ......  3

Consolidated  Statements of Operations - Three and nine months
    ended September 30, 1996 and 1995 .......................................  4

Consolidated Statements of Cash Flows - Nine months ended
    September 30, 1996 and 1995 .............................................  5

Notes to Consolidated Financial Statements - September 30, 1996 .............  6
    

ITEM 2.  Management's Discussion and Analysis of Financial
             Condition and Results of Operations ............................  9


PART II:  OTHER INFORMATION ................................................. 14

ITEM 1.  Legal Proceedings
ITEM 2.  Changes in Securities
ITEM 3.  Defaults Upon Senior Securities
ITEM 4.  Submission of Matters to a Vote of Security Holders
ITEM 5.  Other Information
ITEM 6.  Exhibits and Reports on Form 8-K


SIGNATURES................................................................... 15


*  The financial information contained herein should be read in conjunction with
the consolidated financial statements and notes thereto included in the
Company's Report on Form 10-K for the year ended December 31, 1995, filed on
March 14, 1996.


                                       2

<PAGE>

                        ARRIS PHARMACEUTICAL CORPORATION
                                           
PART 1:   FINANCIAL INFORMATION
ITEM 1.  FINANCIAL STATEMENTS
                                           
                          CONSOLIDATED BALANCE SHEETS

<TABLE>
<CAPTION>
                                                                September 30,  December 31,
                                                                   1996           1995
                                                                (unaudited)
                                                                -------------  ------------
                                                                       (IN THOUSANDS)
<S>                                                                <C>           <C>
ASSETS   
Current assets:
  Cash and cash equivalents                                        $  4,407      $ 21,706
  Short-term marketable investments                                  41,148         9,399
  Prepaid expenses and other current assets                           2,438           798
                                                                   --------      --------
    Total current assets                                             47,993        31,903
                                                                               
Long-term marketable investments                                     16,586           --  
Restricted investments                                                4,250           --  
Property and equipment, net                                           8,217         7,423
Other assets                                                            851           967
                                                                   --------      --------
    TOTAL ASSETS                                                   $ 77,897      $ 40,293
                                                                   --------      --------
                                                                   --------      --------
                                                                               
LIABILITIES AND STOCKHOLDERS' EQUITY                                           
Current liabilities:                                                           
  Accounts payable                                                 $  1,087      $    872
  Accrued compensation                                                1,519         1,718
  Other accrued liabilities                                           1,434         2,651
  Current portion of deferred revenue                                 9,556         8,585 
  Current portion of capital lease and debt obligations               2,147         2,699
                                                                   --------      --------
    Total current liabilities                                        15,743        16,525
                                                                               
Deferred revenue, noncurrent                                          2,667         5,472
Capital lease and debt obligations, net of current portion            5,986         3,263
Convertible acquisition liability                                     6,185         6,185
Minority interest payable                                               --          1,570
                                                                               
Stockholders' equity:                                                          
  Preferred stock, $.001 par value; 10,000,000 shares authorized,              
   none issued or outstanding                                           --            -- 
  Common stock, $.001 par value; 30,000,000 shares authorized,                 
   14,268,498 shares and 10,169,076 shares issued and outstanding              
   at September 30, 1996 and December 31, 1995, respectively        109,470        64,389
  Note receivable from officer                                         (950)         (200)
  Deferred compensation                                                 --            (35)
  Accumulated deficit                                               (61,204)      (56,876)
                                                                   --------      --------
      Total stockholders' equity                                     47,316         7,278
                                                                   --------      --------
    TOTAL LIABILITIES AND STOCKHOLDERS' EQUITY                     $ 77,897      $ 40,293
                                                                   --------      --------
                                                                   --------      --------
</TABLE>

                                           
          See accompanying notes to consolidated financial statements.

                                       3

<PAGE>

                       ARRIS PHARMACEUTICAL CORPORATION
                                           
                     CONSOLIDATED STATEMENTS OF OPERATIONS
                                 (unaudited)


<TABLE>
<CAPTION>
                                             Three Months Ended   Nine Months Ended
                                                 September 30,       September 30,
                                             ------------------   -----------------
                                                1996      1995      1996      1995
                                              -------   -------   -------   -------
                                             (IN THOUSANDS, EXCEPT PER SHARE AMOUNTS)
<S>                                           <C>       <C>       <C>       <C>
Revenues                                      $ 5,161   $ 4,445   $16,195   $12,266

Operating expenses:
  Research and development                      5,615     3,731    18,126    10,925
  General and administrative                    1,289     1,210     3,879     3,349
  Acquired in-process research & development      230       --        230       --
                                              -------   -------   -------   -------
    Total operating expenses                    7,134     4,941    22,235    14,274
                                              -------   -------   -------   -------
Operating loss                                 (1,973)     (496)   (6,040)   (2,008)

Interest income                                   879       305     2,198       947
Interest expense                                 (208)     (103)     (486)     (228)
                                              -------   -------   -------   -------

Net loss                                      $(1,302)  $  (294)  $(4,328)  $(1,289)
                                              -------   -------   -------   -------
                                              -------   -------   -------   -------

Net loss per share                            $ (0.09)  $ (0.03)  $ (0.34)  $ (0.15)
                                              -------   -------   -------   -------
                                              -------   -------   -------   -------

Shares used in computing net loss per share    14,136     8,727     12,803    8,697
                                              -------   -------   -------   -------
                                              -------   -------   -------   -------
</TABLE>


          See accompanying notes to consolidated financial statements. 

                                       4

<PAGE>

                           ARRIS PHARMACEUTICAL CORPORATION 
                                           
                        CONSOLIDATED STATEMENTS OF CASH FLOWS 
                                     (unaudited)

<TABLE>
<CAPTION>
                                                                Nine months ended
                                                                   September 30,
                                                               --------------------
                                                                 1996        1995
                                                               --------     -------
                                                                  (IN THOUSANDS)
<S>                                                            <C>         <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss                                                       $ (4,328)    $(1,289)
Adjustments to reconcile net loss to net cash and
 cash equivalents used in operating activities:
    Depreciation and amortization                                 2,981       1,822
    Stock grants issuable to employees                               21          50
    Loss on fixed assets                                            184          50
    Acquired in-process research and development                    230         --
    Changes in assets and liabilities:
      Prepaid expenses and other current assets                  (1,665)         47
      Other assets                                                  (15)        (33)
      Accounts payable, accrued liabilities and  
       deferred revenue                                          (2,821)     (1,803)
                                                               --------     -------
Net cash and cash equivalents used in operating activities       (5,413)     (1,156)
                                                               --------     -------

CASH FLOWS FROM INVESTING ACTIVITIES:
Note receivable from officer                                       (750)        --
Available-for-sale securities:
  Purchases                                                     (10,915)     (8,808)
  Maturities                                                        --       10,907
Purchase of held-to-maturity security
  Purchases                                                     (59,323)     (3,506)
  Maturities                                                     17,653         --
Expenditures for property and equipment                          (3,765)     (2,883)
                                                               --------     -------
Net cash and cash equivalents used in investing activities      (57,100)     (4,290)
                                                               --------     -------

CASH FLOWS FROM FINANCING ACTIVITIES:
Net proceeds from issuance of common stock                       43,043         349
Proceeds from notes payable and lease financing                   6,164       1,820
Principal payments on notes payable and capital leases           (3,993)     (1,251)
                                                               --------     -------
Net cash and cash equivalents provided by financing 
 activities                                                      45,214         918
                                                               --------     -------

Net decrease in cash and cash equivalents                       (17,299)     (4,528)
Cash and cash equivalents, beginning of period                   21,706      17,165
                                                               --------     -------

Cash and cash equivalents, end of period                       $  4,407     $12,637
                                                               --------     -------
                                                               --------     -------
</TABLE>

           See accompanying notes to consolidated financial statements. 

                                       5


<PAGE>

                           ARRIS PHARMACEUTICAL CORPORATION 
                                           
                      NOTES TO CONSOLIDATED FINANCIAL STATEMENTS
                                  SEPTEMBER 30, 1996
                                      (unaudited)
                                           

1.  ORGANIZATION AND SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

ORGANIZATION

Arris Pharmaceutical Corporation, a Delaware corporation ("Arris" or the
"Company"), uses an integrated drug discovery approach combining structure-based
drug design, combinatorial chemistry and its proprietary Delta Technology to
discover and develop a number of diverse synthetic small molecule therapeutics
for commercially important disease categories where existing therapies have
significant limitations.  Arris' product development programs include: (1)
protease-based discovery programs targeting the inhibition of enzymes implicated
in inflammatory and other diseases, and (2) receptor-based discovery programs
including those designed to discover small molecule drugs that mimic important
therapeutic proteins that are already successful products.

The consolidated financial statements include the accounts of the Company and
its wholly-owned subsidiaries, Arris Protease, Inc., and Arris Pharmaceuticals
Canada, Inc. ("Arris Canada") (See Note 4). All significant intercompany
accounts and transactions have been eliminated.


BASIS OF PRESENTATION

The unaudited consolidated financial statements included herein have been
prepared by the Company according to the rules and regulations of the Securities
and Exchange Commission.  Certain information and footnote disclosures normally
included in complete financial statements prepared in accordance with generally
accepted accounting principles have been condensed or omitted pursuant to such
rules and regulations.  The financial statements reflect, in the opinion of
management, all adjustments (which include only normal recurring adjustments)
necessary to state fairly the financial position and results of operations as of
and for the periods indicated.  The results of operations for the three and nine
month periods ended September 30, 1996 are not necessarily indicative of the
results to be expected for subsequent quarters or the full fiscal year. 

These financial statements should be read in conjunction with the audited
financial statements and the notes thereto included in the Company's 1995 Annual
Report on Form 10-K filed with the Securities and Exchange Commission. 


                                       6

<PAGE>

                       ARRIS PHARMACEUTICAL CORPORATION 
                                           
            NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
                                           

2.  CASH AND CASH EQUIVALENTS AND MARKETABLE SECURITIES

The Company considers all highly liquid investments with maturities of three
months or less at the date of purchase to be cash equivalents.  Marketable
investments consist of U.S. treasury and agency securities, municipal
obligations and high-grade corporate obligations.  Amortization of premiums and
accretion of discounts to maturity are included in interest income.

SECURITIES HELD-TO-MATURITY:   Management determines the appropriate
classification of debt securities at the time of purchase and reevaluates such
designation as of each balance sheet date. Debt securities are classified as
held-to-maturity  when the Company has the positive intent and ability to hold
the securities to maturity. Held-to-maturity securities are stated at amortized
cost.

The following is a summary of held-to-maturity debt securities at September 30,
1996 and December 31, 1995:

<TABLE>
<CAPTION>
                                            HELD-TO-MATURITY SECURITIES
                                    -------------------------------------------
                                               GROSS        GROSS     ESTIMATED 
                                             UNREALIZED   UNREALIZED     FAIR 
                                     COST      GAINS        LOSSES      VALUE
                                    -------  ----------   ----------  ---------
                                                   (IN THOUSANDS)
<S>                                 <C>         <C>         <C>        <C>
Balances at September 30, 1996              
U.S. treasury securities            $24,009     $  14       $ --       $24,023
U.S. agency securities                8,351         5          (7)       8,349
U.S. corporate securities            18,709        14          (7)      18,716
                                    -------     -----       -----      -------
                                    $51,069     $  33       $ (14)     $51,088
                                    -------     -----       -----      -------
                                    -------     -----       -----      -------

Balances at December 31, 1995
U.S. treasury securities            $ 5,015     $ --        $(101)     $ 4,914
U.S. agency securities                7,392       --          (23)       7,369
U.S. corporate securities            11,487       --          (14)      11,473
                                    -------     -----       -----      -------
                                    $23,894     $ --        $(138)     $23,756
                                    -------     -----       -----      -------
                                    -------     -----       -----      -------
</TABLE>

Of the $51,069,000 in held-to-maturity securities described above, at September
30, 1996, $41,148,000 were short-term marketable investments, $5,671,000 were
considered long-term marketable investments and $4,250,000 were long-term
restricted investments under the terms of a bank line of credit (See Note 3). 
Of the $23,894,000 in held-to-maturity securities at December 31, 1995,
$14,495,000 were cash equivalents, and $9,399,000 were short-term marketable
investments.  As of September 30, 1996, the average remaining portfolio duration
of held-to-maturity securities was approximately 8 months.  


                                       7

<PAGE>

                                           
                      ARRIS PHARMACEUTICAL CORPORATION 
                                           
            NOTES TO CONSOLIDATED FINANCIAL STATEMENTS (CONTINUED)
                                           
SECURITIES AVAILABLE-FOR-SALE:  Debt securities not classified as 
held-to-maturity are classified as available-for-sale. Available-for-sale 
securities are stated at fair market value, with the unrealized gains and 
losses included in accumulated deficit.   The Company had $9,909,000 in U.S. 
treasury notes and $1,006,000 in corporate securities at September 30, 1996 
classified as available-for-sale.  The fair value of these securities 
approximated cost. These securities are included in long-term marketable 
investments at September 30, 1996.  The Company had no securities classified 
as available-for-sale at December 31, 1995.

3.  NOTE PAYABLE

In September, 1996, the Company contracted for a new $12 million revolving line
of credit with Bank of America National Trust and Savings Association.  The
interest rate under the agreement is the bank's prime rate less 1% (6.75% at
September 30, 1996).  Interest is payable monthly until April, 1998, at which
time the principal and interest become due over 20 quarterly installments.  Any
borrowings under the agreement are collateralized by certain of the Company's
investment securities which are recorded as Restricted Investments at September
30, 1996.  At September 30, 1996, the Company had borrowed $3.4 million and had
available $8.6 million on this line of credit.


4.   ARRIS CANADA

On July 9, 1996, in connection with the Company's acquisition of Khepri
Pharmaceuticals, Inc. in December, 1995, the minority interest investors in
Arris Canada exercised their right to exchange their interest in Arris Canada
for 161,418 shares of the Company's common stock.  Upon conversion of their
shares in Arris Canada, Arris Canada became a wholly owned subsidiary of the
Company.  The fair value of the shares issued to those minority interest
investors on the date of exercise exceeded the book value of the minority
interest in Arris Canada by $230,000.  This amount has been recorded as expense
for Acquired in-process research and development.

5.  RELATED PARTY TRANSACTIONS

On September 3, 1996, the Company loaned $750,000 to an executive officer for 
the purpose of assisting in the purchase of a residence.  The loan is 
full-recourse and is secured by 130,236 shares of the Company's common stock 
owned by the executive.  The loan is subject to an interest rate of  6.02% 
per annum. All accrued interest and principal are due September 3, 1998.

                                       8

<PAGE>
                      ARRIS PHARMACEUTICAL CORPORATION
                                           
ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION 
                        AND RESULTS OF OPERATIONS

THIS QUARTERLY REPORT ON FORM 10-Q CONTAINS, IN ADDITION TO HISTORICAL
INFORMATION, FORWARD-LOOKING STATEMENTS THAT INVOLVE RISKS AND UNCERTAINTIES. 
THE COMPANY'S ACTUAL RESULTS COULD DIFFER SIGNIFICANTLY FROM THE RESULTS
DISCUSSED IN THE FORWARD-LOOKING STATEMENTS.  FACTORS THAT COULD CAUSE OR
CONTRIBUTE TO SUCH DIFFERENCES INCLUDE, BUT ARE NOT LIMITED TO, THOSE DISCUSSED
BELOW AS WELL AS THOSE DISCUSSED IN THE COMPANY'S PROSPECTUS DATED MARCH 22,
1996.

OVERVIEW

Since its inception in April 1989, the Company has devoted substantially all of
its resources to its research and development programs.  To date, the Company's
only source of revenue has been its corporate collaborations with Pharmacia &
Upjohn, Inc. and its predecessors ("PNU"), Amgen, Inc. ("Amgen"), Bayer AG
("Bayer") and SmithKline Beecham Corporation ("SB").

In September, 1996, Bayer informed the Company that it had initiated the
development of a tryptase inhibitor, BAY 17-1998, with the goal of entering into
clinical trials for the treatment of asthma.  As a result, the Company
recognized a milestone payment as revenue in September 1996.

The Company has not been profitable since inception and expects to incur
substantial losses for at least the next several years, primarily due to the
cost of its research and development programs, including preclinical studies and
human clinical trials.  The Company expects that losses will fluctuate from
quarter to quarter, that such fluctuations may be substantial, and that 
results from prior quarters may not be indicative of future operating results. 
As of September 30, 1996, the Company's accumulated deficit was approximately
$61.2 million.

RESULTS OF OPERATIONS

The Company's revenues increased to $5.2 million and $16.2 million for the 
three- and nine-month periods ended September 30, 1996, respectively, as 
compared to $4.4 million and $12.3 million, respectively for the comparable 
periods in 1995. All of the Company's revenues presently are attributable to 
Collaborations with PNU, Amgen, Bayer and SB. These increases in 1996 were 
primarily due to:  (i) the full effect of research funding in the nine-month 
period ended September 30, 1996 of the high throughput screening 
collaboration with PNU which commenced in April 1995, (ii) the full effect of 
research funding in both the three-month and nine-month periods ended 
September 30, 1996 of the collaboration with PNU for the discovery and 
development of oral antithrombotics which commenced in August 1995, (iii) the 
up-front fee and research funding for the combinatorial chemistry 
collaboration with PNU, which commenced in March 1996, (iv) the up-front fee 
and research funding for the collaboration with SB to apply Arris' Delta 
technology to certain viral proteases, which commenced in June 1996, and (v) 
the recognition of a milestone payment from Bayer under the tryptase program. 
 These increases were partially offset by lower revenues recognized under the 
erythropoetin collaboration with Amgen and the human growth hormone 
collaboration with PNU. Revenues in the fourth quarter of 1996 are expected 
to approximate those in the third quarter.

                                       9

<PAGE>

                       ARRIS PHARMACEUTICAL CORPORATION
                                           
ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                     AND RESULTS OF OPERATIONS (CONTINUED)


Research and development expenses increased to $5.6 million and $18.1 million
for the three- and nine-month periods ended September 30, 1996 respectively,
from $3.7 and $10.9 million in the comparable periods in 1995.  This increase
was primarily due to the expansion of the Company's research efforts in new and
existing programs and the expenses of programs and facilities added as part of
the December 22, 1995 acquisition of Khepri Pharmaceuticals, Inc. ("Khepri"). 
The Company expects its research and development costs to increase during the
remainder of 1996 and into 1997 due to expansion of its research programs and
the conduct of  preclinical studies and clinical trials. 

The Company's general and administrative expenses increased to $1.3 million and
$3.9 million for the three- and nine-month periods ended September 30, 1996 from
$1.2 and $3.3 million in the comparable periods in 1995.  The increase in
expenses for the three- and nine-month periods was primarily due to the
acquisition of Khepri, and the addition of general and administrative personnel
in support of the Company's expanded research and development efforts.  In spite
of the overall increase, general and administrative expenses as a percentage of
total expenses has decreased in the three-month period to 18% in 1996 from 24%
in 1995 and in the nine-month period to 17% in 1996 from 23% in 1995.  The
Company expects its general and administrative costs to increase for the
remainder of 1996 and into 1997 in support of expanded research and development.

On July 9, 1996, in connection with the Company's acquisition of Khepri
Pharmaceuticals, Inc. in December, 1995, the minority interest investors in
Arris Pharmaceuticals Canada, Inc. ("Arris Canada"), exercised their right to
exchange their interest in Arris Canada for 161,418 shares of the Company's
common stock.  Upon conversion of their shares in Arris Canada, Arris Canada
became a wholly owned subsidiary of the Company.  The fair value of the shares
issued to those minority interest investors on the date of exercise exceeded the
book value of the minority interest in Arris Canada by $230,000.  This amount
has been expensed as Acquired in-process research and development.

Interest income increased to $879,000 and $2.2 million, respectively, for the 
three- and nine-month periods ended September 30, 1996 from $305,000 and 
$947,000 in the comparable periods in 1995. The increase was largely due to 
the higher average cash balances in 1996 resulting from receipt of net 
proceeds of approximately $36 million from the follow-on offering of 
3,000,000 shares of the Company's common stock which closed on March 27, 
1996, approximately $5.5 million from the exercise on April 24, 1996 by the 
underwriters of the over allotment option in the offering of 450,000 shares 
and to the receipt of up-front fees collected under new collaborations.  
Interest expense increased to $208,000 and $486,000, respectively for the 
three- and nine-month periods ended September 30, 1996 from $103,000 and 
$228,000 in the comparable periods of 1995 as a result of higher average debt 
balances incurred to finance the expansion of the Company's facilities and 
acquisition of lab equipment. 

                                       10

<PAGE>

                       ARRIS PHARMACEUTICAL CORPORATION
                                           
ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                     AND RESULTS OF OPERATIONS (CONTINUED)

LIQUIDITY AND CAPITAL RESOURCES

The Company has financed its operations since inception primarily through
private and public offerings of its capital stock and through corporate
collaborations.  As of September 30, 1996, the Company had realized
approximately $89.9 million in net proceeds from offerings of its capital 
stock.

In addition, the Company has realized $55.8 million from its corporate
collaborations (excluding the $5.4 million equity investment in the Company made
by PNU). 

The Company's principal sources of liquidity are its cash and investments, which
totaled $66.4 million as of September 30, 1996.   

In September 1996, the Company contracted for a $12 million line of credit from
Bank of America.  As of September 30, 1996 the Company had borrowed $3.4 million
and had $8.6 million remaining available under this line of credit.

Net cash used by operating activities during the nine-month period ended
September 30, 1996 was $5.4 million compared to $1.2 million in the same period
in 1995.  This included receipt of an up-front commitment fee from PNU in
connection with the combinatorial chemistry collaboration agreement initiated in
March 1996 and one from SB in connection with the antiviral collaboration begun
in June 1996.  Cash used in operating activities is expected to fluctuate from
quarter to quarter depending, in part, upon the timing and amounts, if any, of
cash received from existing and any new collaboration agreements. 

The Company also spent approximately $3.8 million for the purchase of property,
plant and equipment during the nine months ended September 30, 1996.  Additional
equipment will be needed as the Company increases its research and development
activities.  The Company received net financing of $2.2 million, net of
principal repayments under new and existing credit instruments and lease
agreements during the nine-months ended September 30, 1996.

The Company's revenues presently are attributable to collaborations with PNU,
Amgen, Bayer and SB.  The PNU human growth hormone collaboration extends through
April 1997.  The Amgen erythropoetin collaboration extends through mid-February
1997.  The proof of concept phase of the SB collaboration ends in June 1997 and
can be extended by SB beyond that into a research phase.  All of the Company's
other collaborations extend beyond the next 12 months.  If the Company is unable
to renew any of these collaborations or extend the SB collaboration into the
research phase, such events may have a material adverse effect on the Company's
business and financial condition.

The cash received by the Company under all collaborations for the nine months 
ended September 30, 1996 was approximately $14.1 million.  This includes 
up-front payments from PNU in connection with the combinatorial chemistry 
agreement which commenced in March, 1996 and from SB in connection with the 
antiviral collaboration which commenced in June 1996.

                                       11

<PAGE>

                        ARRIS PHARMACEUTICAL CORPORATION
                                           
ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION
                     AND RESULTS OF OPERATIONS (CONTINUED)


The aggregate collaboration funding to be received by the Company in 1996 is
expected to be approximately $17.3 million, excluding all future payments which
may be received upon the achievement of future milestones.  There can be no
assurance that the research support or any milestone payments will be realized
on a timely basis or at all.

The Company expects that its existing capital resources, including research and
development revenues from existing collaborations, will enable the Company to
maintain current and planned operations through at least the next 48 months. 
The Company may need to raise substantial additional capital to fund its
operations before the end of such period.  The Company expects that it will seek
such additional funding through new collaborations, through the extension of
existing collaborations or through public or private equity or debt financing.

There can be no assurance that additional financing will be available on
acceptable terms or at all.  All additional funds are raised by issuing equity
securities, further dilution to stockholders may result.  If adequate funds are
not available, the Company may be required to delay, to reduce the scope of or
to eliminate one or more of its research or development programs or to obtain
funds through arrangements with collaborative partners or others that may
require the Company to relinquish rights to certain of its technologies or
products that the Company would otherwise seek to develop or commercialize
itself.

RECENT EVENTS

In August, 1996, the Company entered into a 10-year lease for additional
laboratory and office space in South San Francisco, California.  In October,
1996 the Company agreed to sublet to a third party the facility it had acquired
in the acquisition of  Khepri in December, 1995. Upon implementation of these
arrangements, the Company's facilities increased in net size from approximately
84,000 square feet to approximately 121,000 square feet.


CERTAIN BUSINESS RISKS 

The Company is at an early stage of development.  The Company's technologies
are, in many cases, new and still under development.  All of the Company's
proposed products are in research or development and will require significant
additional research and development efforts prior to any commercial use,
including extensive preclinical and clinical testing as well as lengthy
regulatory approval.  There can be no assurance that the Company's research and
development efforts will be successful, that any of its proposed products will
prove to be safe and efficacious in the clinical trials or that any commercially
successful products will ultimately be developed by the Company.  In addition,
many of the Company's currently proposed  


                                       12

<PAGE>

                           ARRIS PHARMACEUTICAL CORPORATION
                                           
ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION 
                     AND RESULTS OF OPERATIONS (CONTINUED)


products are subject to development and licensing arrangements with the 
Company's collaborators.  Therefore, the Company is dependent on the research 
and development efforts of these collaborators.  Moreover, the Company is 
entitled only to a portion of the revenues, if any, realized from the 
commercial sale of any of the proposed products covered by the 
collaborations.  The Company has experienced significant operating losses 
since its inception and expects to incur significant operating losses over at 
least the next several years.  The development of the Company's technology 
and proposed products will require a commitment of substantial funds to 
conduct these costly and time consuming activities.  All of the Company's 
revenues to date have been received pursuant to the Company's collaborations.

Should the Company or its collaborators fail to perform in accordance with the
terms of any of their agreements, any consequent loss of revenue under the
agreements could have a material adverse effect on the Company's results of
operations.  The proposed products under development by the Company have never
been manufactured on a commercial scale and there can be no assurance that such
products can be manufactured at a cost or in quantities necessary to make them
commercially viable.  The Company has no sales, marketing or distribution
capability.  If any of its products subject to collaborative agreements are
successfully developed, the Company must rely on its collaborators to market
such products.  
                                           
If the Company develops any products which are not subject to collaborative 
agreements, it must either rely on other large pharmaceutical companies to 
market such products or must develop a marketing and sales force with 
technical expertise and supporting distribution capability in order to market 
such products directly.  The foregoing risks reflect the Company's early 
stage of development and the nature of the Company's industry and products.  
Also inherent in the Company's stage of development is a range of additional 
risks, including competition, uncertainties regarding protection of patents 
and proprietary rights, government regulation and uncertainties regarding 
health care reform.


                                       13

<PAGE>


                                           
                       ARRIS PHARMACEUTICAL CORPORATION
                                           

PART II:  OTHER INFORMATION

ITEM 1.       LEGAL PROCEEDINGS
              None

ITEM 2.       CHANGES IN SECURITIES
              None

ITEM 3.       DEFAULTS UPON SENIOR SECURITIES
              None

ITEM 4.       SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS
              None

ITEM 5.       OTHER INFORMATION
              None

ITEM 6.       EXHIBITS AND REPORTS ON FORM 8-K                    
              a)   Exhibits
              
                   10.39  Standard Industrual Lease between the Registrant and
                          The Equitable Life Assurance Society of the United 
                          States, dated August 5, 1996.

                   10.40  Business Loan Agreement between Registrant and 
                          Bank of America National Trust and Savings 
                          Association, dated September 24, 1996.

                   10.41  Sublease Agreement between Registrant and Fibrogen,
                          Inc., dated September 30, 1996.

                   10.42  Promissory Note and Pledge Agreement, dated
                          September 3, 1996, by John P. Walker in favor
                          of Registrant.

                   27     Financial Data Schedule.

              
              b)   Reports on Form 8-K
                   The Company filed no reports on Form 8-K for the quarter 
                   ended September 30, 1996.


                                       14

<PAGE>


                        ARRIS PHARMACEUTICAL CORPORATION
                                           
                                   SIGNATURES
                                           
Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.


                        ARRIS PHARMACEUTICAL CORPORATION



Date:  November 14, 1996    By:  /s/ John P. Walker
                                 -------------------------------------
                                 John P. Walker
                                 President, Chief Executive Officer and Director





Date:  November 14, 1996    By:  /s/ Daniel H. Petree 
                                 -------------------------------------
                                 Daniel H. Petree
                                 Executive Vice President, Corporate
                                 Development and Chief Financial Officer
                                 (Principal Financial and Accounting
                                 Officer) 



                                       15




<PAGE>



                                    EXHIBIT 10.39
                                           
                  STANDARD INDUSTRIAL LEASE - MULTI-TENANT, FULL NET




                                       between


                         THE EQUITABLE LIFE ASSURANCE SOCIETY
                                OF THE UNITED STATES,
                                     as Landlord




                                         and



                          ARRIS PHARMACEUTICAL CORPORATION,
                                      as Tenant


<PAGE>


                  STANDARD INDUSTRIAL LEASE - MULTI-TENANT, FULL NET
                               BASIC LEASE INFORMATION


Date:  August   , 1996
             ---

Landlord:  The Equitable Life Assurance Society of the United States, a New York
      corporation

Tenant:  Arris Pharmaceutical Corporation, a Delaware corporation

Premises (Paragraph l(c)):  The building commonly known as 150-180 Kimball Way,
       South San Francisco, California (the "Main Premises") and 292 East Grand
       Avenue, South San Francisco, California, adjacent to the Building (the
       "Parking Parcel")

Commencement Date (Paragraph 2):  August 5, 1996

Expiration Date (Paragraph 2):  120 months from the Commencement Date

Use (Paragraph 5):  Laboratory, production, manufacturing, general office and
     warehouse uses or any other legal use which is reasonably comparable
     
Base Rent (Paragraph 3):  Months  1 through  3:       $0
                          Months  4 through 12:  $34,500
                          Months 13 through 24:  $37,950
                          Months 25 through 36:  $41,400
                          Months 37 through 60:  $48,300
                          Months 61 through 90:  $51,750
                          Months 91 through 120: $58,650

Tenant's Percentage Share (Paragraph l(f)):  84.15%

    Operating Expenses:  84.15%

    Property Taxes:  84.15%

Security Deposit (Paragraph 48):  $34,500

Tenant's Address for Notices (Paragraph 44):  150 Kimball Way, South
      San Francisco, CA 94080, Attention:  Mr. Dan Petree


                                      -i-


<PAGE>



Landlord's Address for Notices (Paragraph 44):  One Bush St., Suite 1200,
     San Francisco, CA 94104, Attention:  Mr. Michael Evans

Brokers (Paragraph 47):  Jim McPhee and Daniel Harvey of Cushman & Wakefield;
     Randy Scott of Cornish & Carey and Mark Pearson of Catalyst Real Estate
     Group

Exhibit(s) (Paragraph 53):
     Exhibit A   Description of Industrial Center and Building
     Exhibit B   Description of Parking Parcel
     Exhibit C   Landlord's Waiver and Agreement

The provisions of the Lease identified above in parentheses are those provisions
where references to particular Basic Lease Information appear.  Each such
reference shall incorporate the applicable Basic Lease Information.  In the
event of any conflict between any Basic Lease Information and the Lease, the
latter shall control.

TENANT                                 LANDLORD

ARRIS PHARMACEUTICAL                   THE EQUITABLE LIFE ASSURANCE
CORPORATION, a Delaware                SOCIETY OF THE UNITED STATES,
corporation                            a New York corporation

By /s/ Daniel H. Petree                By /s/ Michael A. Evans
  -------------------------              -------------------------

   Its Exec. V.P.                         Its Investment Officer 
      ---------------------                  ---------------------



By                                     By
  -------------------------                -------------------------  

   Its                                     Its
      ---------------------                    ---------------------



                                      -ii-


<PAGE>


<TABLE>

                                  TABLE OF CONTENTS
                                  -----------------
                                                                                 PAGE
                                                                                 ----
<S>                                                                              <C>
1.  Definitions. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .1

2.  Term . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8

3.  Rental . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .8

4.  Additional Charges for Operating Expenses and Property Taxes . . . . . . . . . .9

5.  Use. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

6.  Quiet Enjoyment. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

7.  Personal Property Taxes. . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

8.  Utilities. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

9.  Common Areas . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12

10. Property Insurance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13

11. Liability Insurance. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13

12. Loss Payable Requirements. . . . . . . . . . . . . . . . . . . . . . . . . . . 13

13. Waiver of Subrogation. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

14. Landlord's Right to Perform Tenant's Covenants . . . . . . . . . . . . . . . . 14

15. Maintenance and Repair . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14

16. Surrender of Premises. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

17. Service Contracts. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

18. Waste. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15

19. Options. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

20. Waiver of Repair and Deduct. . . . . . . . . . . . . . . . . . . . . . . . . . 16

</TABLE>

                                         -iii-

<PAGE>

<TABLE>

<S>                                                                               <C>
21. Compliance With Laws . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

22. Hazardous Materials. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16

23. Alterations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18

24. Property of Landlord . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19

25. Damage or Destruction. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 19

26. Waiver . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20

27. Condemnation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20

28. Tenant's Work. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21

29. Mechanic's Liens . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21

30. Financial Statements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21

31. Landlord's Entry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 22

32. Assignment and Subletting. . . . . . . . . . . . . . . . . . . . . . . . . . . 22

33. Subordination. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25

34. Attornment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25

35. Indemnification. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25

36. Attorneys' Fees. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26

37. Landlord Representations . . . . . . . . . . . . . . . . . . . . . . . . . . . 26

38. Events of Default. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26

39. Landlord's Remedies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27

40. Cumulative Remedies. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29

41. No Waivers . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29

42. Application of Tenant Deposits . . . . . . . . . . . . . . . . . . . . . . . . 29

43. Holding Over . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29

</TABLE>

                                         -iv-

<PAGE>

<TABLE>

<S>                                                                               <C>

44. Notices. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29

45. Limitation of Landlord's Liability . . . . . . . . . . . . . . . . . . . . . . 30

46. Estoppel Certificates. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30

47. Brokerage. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30

48. Security Deposit . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31

49. Signage. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31

50. Termination Option . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31

51. Extension Option . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 32

52. Tenant Improvements. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34

53. Equipment Leasing. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 36

54. Miscellaneous. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37


</TABLE>

                                         -v-

<PAGE>



                  STANDARD INDUSTRIAL LEASE - MULTI-TENANT, FULL NET

    THIS LEASE, dated July   , 1996, for purposes of reference only, is made
and entered into by and between THE EQUITABLE LIFE ASSURANCE SOCIETY OF THE
UNITED STATES, a New York corporation ("Landlord") and ARRIS PHARMACEUTICAL
CORPORATION, a Delaware corporation ("Tenant").

                           W I T N E S S E T H:

    Landlord hereby leases to Tenant, and Tenant hereby leases from Landlord
the Premises described in paragraph l(c) below for the term and subject to
matters of record and to the terms, covenants, agreements and conditions
hereinafter set forth, to each and all of which Landlord and Tenant hereby
mutually agree.

    1.    DEFINITIONS.  Unless the context otherwise specifies or requires, the
following terms shall have the meanings herein specified:

    (a)       The term "Industrial Center" shall mean the parcel and other real
property described with precision in Exhibit A, as well as any property interest
in the area of the streets bounding the parcel described in Exhibit A, and all
other improvements on or appurtenances to said parcel or said streets, commonly
known as 100-180 Kimball Way, South San Francisco, California.

    (b)       The term "Building" shall mean the building(s) in which the
Premises are located.

    (c)       The term "Premises" shall mean the portion of the Building which
is crosshatched on the plan(s) included as part of Exhibit A.

    (d)       The term "Operating Expenses" shall mean all of the following
costs, if any, incurred by Landlord with respect to the Industrial Center and
allocable to the Building for:

          (i)    the operation, repair, and maintenance, in neat, clean, and
     good order and condition, of the Industrial Center, including without
     limitation: (A) all buildings and improvements located thereon, (B) all
     parking areas, loading and unloading areas, trash areas, roadways,
     sidewalks, walkways, driveways,

                                    -1-

<PAGE>

     landscaped areas, striping, bumpers, irrigation systems, lighting 
     facilities, fences, and gates; (C) trash disposal services; (D) tenant
     directories; (E) fire detection systems, including sprinkler system 
     maintenance and repair; (F) security services; and (G) any other services
     to be provided by Landlord described elsewhere in this Lease as an
     Operating Expense;

          (ii)  any deductible portion of an insured loss (other than a loss
     due to earthquake) concerning any of the items or matters described in this
     subparagraph (d) not to exceed twenty-five thousand dollars ($25,000);

         (iii)  the cost of the premiums for the insurance policies to be
     maintained by Landlord under this Lease, except any premium for insurance
     for damage or destruction of the Industrial Center caused by an earthquake;

          (iv)  the cost of heat, water, sewer, gas, electricity, and any other
     utilities and services furnished to the Industrial Center, including
     without limitation the Common Areas (as defined in paragraph 9 below) that
     are not paid directly by Tenant (collectively, "Utilities"); and

           (v)  such other items as are now or hereafter customarily included in
     the costs of managing, operating, maintaining, overhauling, and repairing
     comparable multi-tenant industrial centers in accordance with now or
     hereafter accepted accounting or management principles or practices,
     including without limitation reasonable reserves for replacements.

     Landlord agrees that since one of the purposes of Operating Expenses is to
allow Landlord to require Tenant to pay for the costs attributable to the Common
Areas, Landlord agrees that (i) Landlord will not collect or be entitled to
collect Operating Expenses from all of its tenants in an amount which is in
excess of one hundred percent (100%) of the Operating Expenses actually paid by
Landlord in connection with the operation of the Industrial Center, and (ii)
Landlord shall make no profit from

                                       -2-


<PAGE>



Landlord's collections of Operating Expenses. All assessments and premiums
which are not specifically charged to Tenant which can be paid by Landlord in
installments, shall be paid by Landlord in the maximum number of installments
permitted by law and shall not be included as Operating Expenses except in the
year in which the assessment or premium installment is actually paid;

    Each time Landlord provides Tenant with an actual and/or estimated
statement of Operating Expenses, such statement shall be itemized on a line-item
basis showing the expenses for the applicable year and the year prior thereto.

    Notwithstanding anything to the contrary in the definition of "Operating
Expenses," Operating Expenses shall NOT include any of the following:

     (i)      any Ground Lease rentals;

     (ii)     expenditures required by Landlord's failure to comply with laws 
enacted on or before the date any Industrial Center building's certificate of 
occupancy is validly issued;

     (iii)    costs incurred by Landlord for the repair of damage to, or 
maintenance of, any building or other improvement in the Industrial Center 
resulting from casualty loss (except the deductible portion of an insured 
loss to the extent provided in paragraph 1(d)(ii) above) and the costs of 
maintaining and repairing the structural components of any building (or other 
improvement in the Industrial Center) consisting of beams, columns, 
foundation, footings, structural slabs and structural parts of the roof, 
except as to any structural changes made or components installed specifically 
for Tenant;

     (iv)     costs, including permit, license and inspection costs, incurred 
with respect to the installation of tenant improvements for any other tenant 
or occupant in the Industrial Center or incurred in renovating or otherwise 
improving, decorating, painting or redecorating vacant space for any other 
tenant or occupant of the Industrial Center;

     (v)      depreciation, amortization and interest payments with respect 
to any building or other improvement in the Industrial Center or Common Area 
or any equipment or machines, except as provided herein and except on 
materials, tools, supplies and

                                       -3-

<PAGE>

vendor-type equipment purchased by Landlord to enable Landlord to supply 
services Landlord might otherwise contract for with a third party where such 
depreciation, amortization and interest payments would otherwise have been 
included in the charge for such third parties' services, all as determined in 
accordance with generally accepted accounting principles, consistently 
applied, and when depreciation or amortization is permitted or required, the 
item shall be amortized over its reasonably anticipated useful life;

     (vi)     marketing costs, including leasing commissions and attorney's 
fees, and other costs and expenses incurred in connection with negotiation 
and preparation of letters, deal memos, assignments, space planning costs and 
other costs and expenses incurred in connection with lease, sublease and/or 
assignment negotiations and transactions with present or prospective tenants 
or other occupants of the Industrial Center;

     (vii)    costs incurred by Landlord for alterations which are considered 
capital repairs, improvements, replacements and equipment under generally 
accepted accounting principles, consistently applied, or otherwise ("Capital 
Items"); except for those Capital Items (1) acquired to reduce Operating 
Expenses, amortized at an annual rate reasonably calculated to equal the 
amount of Operating Expenses saved by each calendar year throughout the Lease 
term as determined at the time Landlord elected to proceed with the capital 
improvement or acquisition of the capital equipment to reduce Operating 
Expenses, together with interest the actual interest rate incurred by 
Landlord, or (2) costs of capital tools not in excess of Ten Thousand Dollars 
($10,000.00) in any twelve (12) month period;

     (viii)   interest, principal, points and fees on debts or amortization 
on any mortgage or mortgages or any other debt instrument encumbering all or 
any portion of the Property; 

     (ix)     advertising and promotional expenditures, and costs of signs on 
or about the Industrial Center identifying the owner of the Industrial Center 
or any tenant thereof;

     (x)      tax penalties incurred as a result of Landlord's inability to 
make tax payments when due, and costs, expenses and penalties incurred by 
Landlord as a result of Landlord's violation of any laws, rules or 
regulations, including, without

                                       -4-

<PAGE>

limitation, those governing the use, storage, removal or cleanup of any toxic 
or hazardous materials;

     (xi)     any increase in real property taxes ("Tax Increase") resulting 
from a "change in ownership" (as defined in California Revenue and Taxation 
Code, division 1, the statutes, rules and regulations thereunder, and any 
amendments and successors thereto), except a Tax Increase resulting from a 
"change in ownership" due to a transfer to a bona fide third party;

     (xii)    costs incurred by Landlord for the repair of damage to any 
improvements in the Industrial Center resulting from the negligence or 
willful misconduct of Landlord or its agents, employees, invitees or 
contractors, other than costs of routine maintenance and repair and costs to 
repair ordinary wear and tear;

     (xiii)   costs incurred by Landlord in connection with negotiating the 
financing, mortgaging, hypothecating, syndicating, sale or acquisition of all 
or any portion of the Industrial Center;

     (xiv)    premiums attributable to earthquake coverage in any insurance 
policy carried by Landlord, and that portion of the premiums for any 
insurance policy carried by Landlord that is attributable to insurance 
coverage that is in excess of the coverage customarily maintained by 
Landlords or owners of comparable industrial centers in the geographical area 
where the Industrial Center is located;

     (xv)     costs, except for costs of routine maintenance and repair and 
costs to repair ordinary wear and tear, incurred in furnishing items or 
services exclusively to Tenant or any other specific tenant, or in repairing 
damage to the Building caused by Tenant or any other tenant or its or their 
agent, employees, invitees or contractors, to the extent Landlord is entitled 
to reimbursement therefor;

     (xvi)    to the extent the managing agent of the Industrial Center is an 
affiliate of Landlord, that portion of any management fees paid to such 
affiliate that exceeds the management fees customarily charged for the 
management of comparable buildings located in the geographical area where the 
Industrial Center is located; 

                                       -5-

<PAGE>

     (xvii)   the cost or replacement of any item covered by a warranty in 
favor of Landlord, to the extent the benefit of such warranty is received by 
Landlord;

     (xviii)  costs incurred by Landlord in correcting latent or patent 
defects in the improvements in the Industrial Center;

     (xix)    attorneys fees and other costs and expenses incurred due to the 
violation by Landlord or any tenant of any lease of premises in the 
Industrial Center or under any Ground Lease;

     (xx)     rentals and related expenses incurred in leasing air 
conditioning systems, elevators or other equipment that may be classified as 
capital expenditures under generally accepted accounting principles, except 
for rentals and related expenses incurred in connection with the rental of 
such equipment in order to make repairs or keep permanent systems in 
operation while repairs are being made and except for the rental of equipment 
that is not affixed to a building in the Industrial Center and which is used 
in the maintenance or repair of the any improvement in the Industrial Center 
or the provision of other services required to be provided by Landlord 
hereunder;

     (xxi)    costs of remediation of hazardous substances, materials or 
wastes introduced, used, stored or disposed of by Landlord or any tenant 
other than Tenant in, on or about the Industrial Center; and costs of 
remediation of hazardous substances, materials or wastes introduced, used 
stored or disposed of by unknown persons or persons other than Landlord, 
Tenant or any tenant other than Tenant in, on or about the Industrial Center;

     (xxii)   that portion of any real estate taxes for which Landlord is 
entitled to receive reimbursement from any tenant of the Industrial Center;

     (xxiii)  Landlord's general and administrative overhead expenses, to the 
extent not properly allocable to the Industrial Center;

     (xxiv)   the cost of any development fee, any one-time utility 
connection or "tap-in" fees for the Industrial Center, unless such fees are 
due to any Work (as defined below) or Tenant's Work (as defined below);

                                       -6-

<PAGE>

     (xxv)    electric power costs for which any tenant other than Tenant 
directly contracts with the local public service company;

     (xxvi)   costs incurred in connection with upgrading the Industrial 
Center to comply with handicap, life, fire and safety codes in effect prior 
to or subsequent to the Commencement Date and costs incurred in connection 
with the Americans With Disabilities Act (the "ADA") and all other laws, 
codes, ordinances and regulations except that Landlord may charge as 
Operating Expenses up to fifteen thousand dollars ($15,000) of such costs 
over the Lease term;

     (xxvii)  any other expenses which, in accordance with generally accepted 
accounting principles, consistently applied, would not normally be treated as 
Operating Expenses by landlords of comparable Industrial Centers;

     (xxviii) costs for which Landlord has been compensated by a management 
or administrative fee;

     (xxix)   costs arising from Landlord's charitable or political 
contributions;

     (xxx)    costs for sculpture, paintings or other objects of art, except 
if required by a governmental entity;

     (xxxi)   costs (including in connection therewith all attorneys' fees an 
costs of settlement, judgments and payments in lieu thereof) arising from 
claims, disputes or potential disputes in connection with potential or actual 
claims litigation or arbitrations pertaining to the Landlord and/or the 
Industrial Center; and

     (xxxii)  costs associated with the operation of the business of the 
partnership or entity which constitutes Landlord as the same are 
distinguished from the costs of operation of the Industrial Center, including 
partnership accounting and legal matters, costs of defending any lawsuits 
with any mortgagee (except as the actions of Tenant may be in issue), costs 
of any disputes between Landlord and its employees (if any), disputes of 
Landlord with Industrial Center management, or outside fees paid in 
connection with disputes with other tenants.

                                       -7-

<PAGE>

    Actual Operating Expenses for each year shall be adjusted to equal 
Landlord's reasonable estimate of Operating Expenses had the total rentable 
area of the Industrial Center been occupied.  Landlord and Tenant acknowledge 
that certain of the costs of management, operation and maintenance of the 
Industrial Center may be allocated by Landlord exclusively to a single 
component of the Industrial Center (e.g. to the Building, another building 
located in the Industrial Center or a parking facility) and certain of such 
costs may be reasonably allocated by Landlord among such components.

    (e)  The term "Property Taxes" shall mean any form of real property
tax or assessment and any license fee, commercial rental tax, improvement bond
or bonds, levy, or other tax (other than inheritance, personal income, or estate
taxes), general and special, ordinary and extraordinary, foreseen as well as
unforeseen, and of any kind or nature whatsoever, imposed (i) on the Industrial
Center or applicable tax assessor's parcel by any authority having the direct or
indirect power to tax (including any city, state, or federal government, or any
school, agricultural, sanitary, water, fire, street, drainage, or other
improvement district thereof), (ii) against any legal or equitable interest of
Landlord in the Industrial Center, the Building, or the Premises, (iii) against
Landlord's right to rent or other income therefrom, or (iv) against Landlord's
business of leasing the Industrial Center, the Building, or the Premises.  The
term "real property tax(es)" shall also include any tax, fee, levy, assessment,
or charge:  (i) in substitution of, partially or totally, any tax, fee, levy,
assessment, or charge:  included above within the definition of "real property
tax(es)," (ii) that is imposed, added, or increased as a result of a transfer,
either partial or total, of Landlord's interest in the Industrial Center, the
Building, or the Premises, or (iii) that is imposed by reason of this
transaction, any modifications or changes hereto, or any transfers hereof. 
Notwithstanding any of the provisions of this paragraph 1(e) to the contrary,
Tenant shall have no obligation to pay any portion of "Property Taxes" to the
extent attributable to a "change in ownership" as that term is defined in
California Revenue and Taxation section 62 et. seq., except that Tenant shall
pay the portion of Property Taxes due to the transfer of all or any portion of
the Industrial Center to a bona fide third party.

                                       -8-


<PAGE>

    (e)  The term "Tenant's percentage share" shall mean the percentage
figure specified in the Basic Lease Information.  Tenant acknowledges that the
Basic Lease Information may set forth different percentage shares of Operating
Expenses and Property Taxes or a single percentage share applicable to both.

    (g)   The term "Laws" shall mean any federal, state, local and other
laws, codes, orders, ordinances, rules, regulations and statutes.

    2.    TERM.  The term of this Lease shall commence on the Commencement Date
and, unless sooner terminated as hereinafter provided, shall end on the
Expiration Date, as specified in the Basic Lease Information.  As soon as
reasonably possible, but in no event more than sixty (60) days after the
Commencement Date, Tenant shall inspect the Premises, and within such inspection
period, Tenant shall notify Landlord of any defect in the Building or building
systems, including, but not limited to, heating, ventilation and air
conditioning, electrical, roof, and plumbing systems are in good working order. 
Landlord shall repair any defects at Landlord's sole expense.  Tenant accepts
the Premises with all existing tenant improvements and fixtures in place.  If
Landlord, for any reason whatsoever, cannot deliver the Premises to Tenant on
the Commencement Date, this Lease shall not be void or voidable, nor shall
Landlord be liable to Tenant for any loss or damage resulting therefrom, but in
that event rental shall be waived for the period between the Commencement Date
and the time when Landlord delivers the Premises to Tenant.  No delay in
delivery of the Premises shall operate to extend the term of this Lease.  If the
Main Premises is not delivered to Tenant on or before ten (10) days after the
Commencement Date or if the Parking Parcel is not delivered to Tenant on or
before September 12, 1996, Tenant may elect to terminate this Lease by giving
written notice of such election within thirty (30) days of the applicable
delivery date.  No such termination shall alter the obligations of Landlord to
make any portion of Landlord's Initial Contribution (as defined in paragraph
52(f)) with respect to work which has been contracted for or undertaken on or
prior to the date such termination is effective.  Tenant shall have no
obligation to reimburse Landlord for any sums disbursed by Landlord from
Landlord's Initial Contribution.

                                       -9-


<PAGE>


    3.   RENTAL.

    (a)  Tenant shall pay to Landlord throughout the term of this Lease as
monthly rental for the Premises the sum specified in the Basic Lease Information
as the Base Rent, together with all charges and other amounts required under
this Lease as additional rent ("Additional Charges"), including, without
limitation, Tenant's percentage share of the total amount of Operating Expenses
paid or incurred by Landlord in each year and Tenant's percentage share of the
total dollar amount of Property Taxes paid by Landlord in each year.

    (b)  Notwithstanding the provisions of subparagraph (a) above, Tenant
shall not be responsible for paying any portion of any increase in real property
tax that is specified in the tax assessor's records and worksheets as being
caused by additional improvements placed upon the Industrial Center by tenants
of other premises in the Industrial Center or by Landlord for the exclusive
enjoyment of such other tenants.  Tenant shall, however, pay to Landlord at the
time payments on account of Tenant's percentage share of Property Taxes are
payable under paragraph 4 below the entirety of any increase in real property
tax if assessed solely by reason of additional improvements placed upon the
Premises by Tenant or at Tenant's request.

    (c)  Rental shall be paid to Landlord on or before the Commencement
Date and on or before the first day of each and every successive calendar month
thereafter during the term of this Lease.  In the event the term of this Lease
commences on a day other than the first day of a calendar month or ends on a day
other than the last day of a calendar month, the monthly rental for the first
and last fractional months of the term hereof shall be appropriately prorated.

    (d) All sums of money due from Tenant hereunder not specifically
characterized as rental shall constitute additional rent, and if any such sum is
not paid when due it shall nonetheless be collectible as additional rent with
the next installment of rental thereafter falling due, but nothing contained
herein shall be deemed to suspend or delay the payment of any-sum of money at
the time it becomes due and payable hereunder, or to limit any other remedy of
Landlord.

                                       -10-


<PAGE>


    (e)   The term "rent" as used in this Lease shall refer collectively to
the Base Rent and to all additional rent, Additional Charges and other sums
payable hereunder.  Tenant hereby acknowledges that late payment by Tenant to
Landlord of rent and other sums due hereunder after the expiration of any
applicable grace period will cause Landlord to incur costs not contemplated by
this Lease, the exact amount of which will be difficult to ascertain.  Such
costs include, but are not limited to, processing and accounting charges, and
late charges which may be imposed on Landlord by the terms of any trust deed
covering the Premises.  Accordingly, if any installment of rent or any other
sums due from Tenant shall not be received by Landlord when due or if a grace
period is applicable, prior to the expiration of the grace period, Tenant shall
pay to Landlord a late charge equal to one thousand dollars ($1,000).  The
parties hereby agree that such late charge, together with interest thereon as
provided herein, represents a fair and reasonable estimate of the costs Landlord
will incur by reason of late payment by Tenant based upon the circumstances
existing as of the date of this Lease.

    4.   ADDITIONAL CHARGES FOR OPERATING EXPENSES AND PROPERTY TAXES.

    (a)  This Lease is intended to be a completely net lease.  Except as
expressly provided herein, the Base Rent owing hereunder is to be paid by Tenant
absolutely net of all costs and expenses relating to Landlord's ownership and
operation of the Building.  The provisions of this paragraph 4 for the payment
of Tenant's percentage share of Property Taxes and Tenant's percentage share of
Operating Expenses are intended to pass on to Tenant its share of all such costs
and expenses.

    (b)  With respect to each calendar year during the term of this Lease,
Tenant shall pay to Landlord as Additional Charges, at the times hereinafter set
forth, an amount equal to Tenant's percentage share of Operating Expenses and
Property Taxes.  Within ninety (90) days following the commencement of any
calendar year Landlord shall notify Tenant of Landlord's estimate of the amount
of Operating Expenses and Property Taxes for such current calendar year
("Estimated Taxes and Expenses").  Tenant shall pay to Landlord on the first day
of each calendar month during such current calendar year one-twelfth (1/12) of
the amount of any such Estimated Taxes and Expenses for such current calendar
year.  If at any time or times Landlord

                                       -11-


<PAGE>

determines that the amount of Tenant's percentage share of Operating Expenses
or Property Taxes payable by Tenant for the current year will vary from its
estimate by more than five percent (5%), Landlord may, by notice to Tenant,
revise Landlord's estimate for such year, and subsequent payments by Tenant
for such year shall be based on such revised estimate.  Following the close
of each calendar year, Landlord shall deliver to Tenant a statement of the
actual amount of Tenant's percentage share of Operating Expenses and Property
Taxes for the immediately preceding year, accompanied by a statement made by
an accounting or auditing officer designated by Landlord showing the Operating
Expenses and Property Taxes for such year.  Tenant will be entitled one (1) time
per year to audit and verify the operations of the Industrial Center and the
Building and the related books and records of Landlord to assure that the
Operating Expenses from time to time reported by Landlord are in keeping with
a the provisions of this Lease regarding Tenant's obligation to pay a share
of Operating Expenses.  As to any calendar year, any undertaking by Tenant must
be initiated within twelve (12) months following the presentation by Landlord
to Tenant of the statement described herein.  In the event of any errors, the
appropriate party will make a correcting payment in full to the other party
within thirty (30) days after the determination and communication to all
parties of the amount of such error.  In the event of any errors on the part of
Landlord in excess of five percent (5%) of Tenant's actual share of Operating
Expenses liability for that calendar year, Landlord will also reimburse Tenant
for all costs of the audit and verification incurred by Tenant within said
thirty (30) day period.  Within three (3) months of the Commencement Date,
Tenant will be entitled to verify the rentable area of the Industrial 
Center and the Premises, the usable premises area and the Tenant's percentage
share.  In the event of any errors, these terms will be restated to eliminate
the errors.  In the event of any errors in excess of five percent (5%) of the
actual amounts, Landlord will also reimburse Tenant for all costs of the
verification reasonably incurred by Tenant, within thirty (30) days after the
determination and communication to all parties of the amount of the error.  All
amounts payable by Tenant as shown on such statement, less any amounts
theretofore paid by Tenant on account of Estimated Taxes and Expenses for such
calendar year made pursuant to this paragraph 4, shall be paid by or, if Tenant
theretofore shall have paid more than such amounts, reimbursed to Tenant within
thirty (30) days after delivery of such statement to Tenant.

                                       -12-


<PAGE>

    (c)   If the Expiration Date of this Lease is a day other than the last
day of a calendar year, within sixty (60) days after the Expiration Date,
Landlord shall deliver to Tenant a reconciliation statement showing Operating
Expenses incurred during such calendar year to the Expiration Date and the
amount Tenant has paid to date during such calendar year on account of Tenant's
percentage share of Operating Expenses.  If Tenant has paid more than Tenant's
percentage share, Landlord shall promptly refund such excess.  If Tenant has not
paid Tenant's percentage share, Tenant shall promptly pay Landlord the remaining
amount due.

     5.   USE.  The Premises shall be used and occupied only for the use
described in the Basic Lease Information, as permitted by the Laws of the City
of South San Francisco, California, and for no other use or purpose without
obtaining the prior written consent of Landlord which may be granted or denied
in Landlord's sole discretion.  Tenant shall have the right to use 79 unreserved
parking spaces in the area identified on EXHIBIT A hereto and shall have the
exclusive use of the parking area located on the Parking Parcel.

      6.  QUIET ENJOYMENT.  Provided Tenant performs its obligations hereunder,
Tenant shall lawfully and quietly occupy the Premises during the term of this
Lease without hindrance or molestation by Landlord, subject, however, to
applicable Laws, matters of record and the provisions of this Lease.

      7.  PERSONAL PROPERTY TAXES.  Tenant shall pay prior to delinquency all
taxes assessed against and levied upon trade fixtures, furnishings, equipment,
and all other personal property of Tenant contained in the Premises or
elsewhere.

      8.  UTILITIES.  Tenant shall pay directly to the appropriate providers for
all Utilities that are used on the Premises during the term of this Lease. 
Tenant shall pay Landlord, within ten (10) days after receipt of Landlord's
statement therefor, the amount by which, in Landlord's reasonable judgment, the
Utilities used by Tenant at the Premises exceed normal usage at the Industrial
Center for the use described in the Basic Lease Information.

                                       -13-


<PAGE>


      9.  COMMON AREAS.

      (a)   The term "Common Areas" shall mean all areas and facilities
outside the Premises and within the exterior boundary line of the Industrial
Center that are provided and designated by Landlord from time to time for the
general non-exclusive use of Landlord, Tenant, and other tenants of the
Industrial Center and their respective employees, suppliers, shippers,
customers, and invitees, including parking areas, loading and unloading areas,
trash areas, roadways, sidewalks, walkways, parkways, driveways, and landscaped
areas.

      (b)   During the term of this Lease, Tenant and its employees, agents,
suppliers, shippers, customers, and invitees shall have the non-exclusive right
to use, in common with others entitled to such use, the Common Areas as they
exist from time to time, subject to any rights, powers, and privileges reserved
by Landlord under the terms hereof.  Under no circumstances shall Tenant's right
to use the Common Areas be deemed to include the right to store any property,
temporarily or permanently, in the Common Areas.  Any such storage shall be
permitted only by the prior written consent of Landlord or Landlord's designated
agent, which consent may be revoked at any time.  In the event that any
unauthorized storage shall occur, Landlord shall have the right, without notice,
in addition to such other rights and remedies it may have, to remove the
property and charge the cost to Tenant, which cost shall be immediately payable
upon demand.

       (c)  Landlord, or such other persons as Landlord may appoint, shall
have the exclusive control and management of the Common Areas.

       (d)  Provided there is (i) no permanent reduction in the number of
parking spaces allocated to Tenant; (ii) no permanent interference with Tenant's
ingress and/or egress to the Premises, (iii) no permanent relocation of
driveways and entrances; or (iv) any permanent degradation of the character of
the Common Areas, Landlord shall have the right, in its sole discretion, from
time to time:  (i) to make changes to the Common Areas, including without
limitation changes in the location, size, shape, and number of driveways,
entrances, parking spaces, parking areas, loading and unloading areas, ingress,
egress, direction of traffic, landscaped areas, and walkways, (ii) to close
temporarily any of the Common Areas for

                                       -14-


<PAGE>



maintenance purposes so long as reasonable access to the Premises remains
available, (iii) to use the Common Areas while engaged in making additional
improvements, repairs, or alterations to the Industrial Center, or any portion
thereof, and (iv) to do and perform such acts and make such other changes in,
to, or with respect to the Common Areas and Industrial Center as Landlord may,
in the exercise of sound business judgment, deem to be appropriate.

    10.  PROPERTY INSURANCE.  Landlord shall, at Tenant's sole cost and
expense, keep the Premises (including improvements to the Premises constructed
at Landlord's expense) insured for the benefit of Landlord and Tenant in such
amounts and with such coverages as Landlord may reasonably determine to be
adequate.  At a minimum, Landlord shall carry "all risk" insurance with respect
to the Industrial Center in an amount sufficient to cover the full replacement
cost thereof.

    11.  LIABILITY INSURANCE.

    (a)  Tenant agrees to procure and maintain in force during the term
hereof, at Tenant's sole cost and expense, Commercial General Liability
insurance in an amount not less than two million dollars ($2,000,000) combined
single limit for bodily injury and property damage for injuries to or death of
persons and property damage occurring in, on or about the Premises.  Such policy
shall name Landlord, Landlord's managing agent and any other party designated by
Landlord as additional insureds, shall insure Landlords and Landlord's managing
agent's contingent liability as respects acts or omissions of Tenant, shall be
issued by a company licensed to do business in the State of California and
otherwise reasonably acceptable to Landlord, and shall provide that the policy
may not be cancelled nor amended without thirty (30) days prior written notice
to Landlord.  Tenant may carry said insurance under a blanket policy, provided
however, said insurance by Tenant shall include an endorsement confirming
application to and coverage of Landlord.  Said insurance shall be primary
insurance to any other insurance that may be available to Landlord.  Any other
insurance available to Landlord shall be non-contributing with and excess to
this insurance.

     (b)  A certificate of such policy of insurance shall be delivered to
Landlord by Tenant prior to commencement of the term of this Lease and upon each
renewal of such insurance.

                                       -15-


<PAGE>


      (c)   Tenant shall, prior to and throughout the term of this Lease,
procure from each of its insurers under all policies of fire, theft, public
liability, workers' compensation and any other insurance policies of Tenant now
or hereafter existing, pertaining in any way to the Premises or the Building or
any operation therein, a waiver, as set forth in paragraph 13 of this Lease, of
all rights of subrogation which the insurer might otherwise, if at all, have
against the Landlord or any officer, agent or employee of Landlord (including
Landlord's managing agent).

       12.  LOSS PAYABLE REQUIREMENTS.  All policies of insurance required
hereunder, except those policies set forth in paragraph 11(c) above, shall
provide that the proceeds thereof shall be payable to Tenant and Landlord, as
their respective interests may appear, and, if Landlord so elects, the policies
referenced in paragraph 10 may be payable also to the holder of any of
Landlord's mortgages or deeds of trust on the Premises as the interest of such
holder may appear, pursuant to a standard mortgagee clause or a loss payable
clause.

       13.  WAIVER OF SUBROGATION.  Landlord and Tenant each hereby releases the
other from any and all claims, and waives its entire right of recovery against
the other, for loss or damage arising out of or incident to the perils insured
against under paragraphs 10 and 11 above to the extent such loss or damage is
insured against under such policies, whether due to the negligence of Landlord
or Tenant or the agents, employees, contractors, or invitees of either of them.

       14.  LANDLORD'S RIGHT TO PERFORM TENANT'S COVENANTS.  Tenant agrees that,
if Tenant shall at any time fail to make any payment or perform any other act to
be made or performed by it under this Lease, Landlord may, but shall not be
obligated to, make such payment or perform such other act to the extent Landlord
may deem desirable, with full right of offset, and without waiving or releasing
Tenant from any obligation under this Lease.  All sums so paid by Landlord and
all expenses paid in connection therewith, including without limitation
attorneys' fees, together with interest thereon at the Default Interest Rate
(defined in paragraph 50) from the date of such payment, shall be paid by Tenant
to Landlord on demand.

                                       -16-


<PAGE>


        15.  MAINTENANCE AND REPAIR.

        (a)  LANDLORD'S OBLIGATIONS.  Subject to the provisions of
subparagraph (b) and paragraphs 23 and 24 below, and except for damage caused by
any negligent or intentional act or omission of Tenant or any of Tenant's
employees, suppliers, shippers, customers, or invitees, which is not covered by
Landlord's insurance, in which event Tenant shall repair the damage, Landlord,
at Landlord's expense, subject to reimbursement pursuant to paragraph 4 above,
shall keep in good condition and repair the foundations, exterior walls,
structural condition of interior bearing walls, and roof of the Premises, as
well as the parking lots, walkways, driveways, landscaping, fences, signs, and
utility installations of the Common Areas, and shall provide the services for
which Operating Expenses are payable pursuant to paragraph 3.  Except for
obligations specifically undertaken by Landlord in this subparagraph (a),
Landlord shall have no obligation, in any manner whatsoever, to repair or
maintain the Premises.  Landlord shall have no obligation to make repairs under
this subparagraph (a) until a reasonable time after receipt of written notice
from Tenant of the need for such repairs.  In no event shall Landlord be liable
for damages or loss of any kind or nature by reason of Landlord's failure to
furnish any Common Area services when such failure is caused by accident,
breakage, repairs, strikes, lockout, or other labor disturbances or disputes of
any character, or by any other cause beyond the reasonable control of Landlord.

         (b)  TENANT'S OBLIGATIONS.  Except for those areas that are Landlord's
responsibility pursuant to subparagraph (a) above, Tenant shall, at Tenant's
sole cost and expense, keep the entire Premises secure, clean and in good order,
condition, and repair, and shall make promptly all necessary repairs, interior
and exterior, ordinary as well as extraordinary, foreseen as well as unforeseen.
When used in this paragraph, the term "repair(s)" shall include alterations,
replacements, renewals, and Tenant's trade fixtures, Improvements (as defined in
Paragraph 53) and specialized equipment whether or not any such fixtures,
Improvements or equipment are affixed to the Premises.  All repairs shall be
equal in quality and class to the original work, ordinary wear and tear
excepted.

        16.   SURRENDER OF PREMISES.  Upon expiration or any sooner termination
of this Lease, Tenant shall surrender to Landlord the entire Premises, together
with all Alterations (defined in

                                       -17-


<PAGE>


paragraph 24 below), in the same condition as when received or installed,
ordinary wear and tear excepted, and if Tenant has terminated the Lease pursuant
to paragraph 25, damage due to casualty or Act of God shall be excepted, and
clean and free of debris and unaffixed personal property and free of any liens
created or suffered to be created by Tenant. Tenant shall have the right, but
not the obligation to, remove any Trade Fixtures belonging to Tenant, provided
that Tenant shall perform prior to the expiration of the term of this Lease all
restoration made necessary by such removal.  Landlord may, in accordance with
applicable laws, retain or dispose of in any manner any Trade Fixtures or
personal property of Tenant that Tenant does not remove from the Premises upon
expiration or termination of the Lease term, in which case title thereto shall
vest in Landlord.  The term "Trade Fixtures" as used herein shall mean all
fixtures (including without limitation, chemistry hoods and casework),
equipment, and personal property owned by Tenant and used in connection with
the operation of any business on the Premises, whether or not affixed to the
Building.

     17.   SERVICE CONTRACTS.  Tenant shall, at Tenant's sole cost and expense,
enter into a regularly scheduled preventive maintenance/service contract with a
maintenance contractor for servicing all hot water, heating, and air
conditioning systems, and elevators (if there be any) within the Premises.  The
maintenance contractor and the contract shall be subject to the approval of
Landlord.  The contract shall include all services suggested by the equipment
manufacturers and shall become effective, and a copy thereof shall be delivered
to Landlord, within thirty (30) days of the date Tenant takes possession of the
Premises.

      18.  WASTE.  Tenant shall not do or suffer any waste or damage,
disfigurement, or injury to the Premises or permit or suffer any overloading of
the floors of the Building.

      19.  OPTIONS.  Anything in this Lease or any of its addenda or amendments
to the contrary notwithstanding, if during any twelve (12) month-period of the
term of this Lease, three (3) or more material events of default by Tenant
(i.e., monetary defaults as set forth in paragraph 38(a), failure to carry
insurance, breach of other tenants' right of quiet enjoyment, an event of
default as set forth in paragraph 38(b) or use of the Premises that is not
lawful) have occurred, all of Tenant's rights, if any, to expand or increase the
size of the Premises

                                       -18-


<PAGE>


or to extend the term of this Lease, shall cease, expire and be at an end.

      20.  WAIVER OF REPAIR AND DEDUCT.  Tenant hereby waives any and all rights
it may have to make repairs at Landlord's expense or in lieu thereof to vacate
the Premises as provided in California Civil Code Section 1942 or any other law,
statute,-or ordinance now or hereafter in effect.

      21.  COMPLIANCE WITH LAWS.  Landlord shall be responsible for complying,
at Landlord's sole cost and expense, without reimbursement from Tenant, with the
ADA as it relates to the existing sidewalks and parking area, except the parking
area on the Parking Parcel, in the Industrial Center and the path of travel to
the entrances and exits from the Building.  Tenant shall, at Tenant's sole cost
and expense, comply promptly with all Laws and with the recommendations of any
insurer under any policies required under this Lease, that may be applicable to
Tenant's particular use of the Premises.  To Landlord's current actual
knowledge, the Premises complies with the ADA as such act is currently
interpreted, excepting a bathroom vanity in the men's bathroom located on the
first floor, as has been previously disclosed to Tenant.  Landlord agrees to
remove such bathroom vanity within thirty (30) days of receiving a written
request for such removal from Tenant.  Notwithstanding the foregoing, Landlord,
without reimbursement from Tenant, shall perform any work required to bring the
Common Areas into compliance with the ADA, except that Landlord shall have the
right of reimbursement set forth in paragraph 1(c)(xxvi).

       22.  HAZARDOUS MATERIALS.

       (a)  The term "Hazardous Material" shall mean any substance that is
(a) defined under any Environmental Law as a hazardous substance, hazardous
waste, hazardous material, pollutant or contaminant, (b) a petroleum
hydrocarbon, including crude oil or any fraction or mixture thereof,
(c) hazardous, toxic, corrosive, flammable, explosive, infectious, radioactive,
carcinogenic or a reproductive toxicant, or (d) otherwise regulated pursuant to
any Environmental Law.  The term "Environmental Law" shall mean all federal,
state and local laws, statutes, ordinances, regulations, rules, judicial and
administrative orders and decrees, permits, licenses, approvals, authorizations
and similar requirements of all federal, state and local governmental agencies
or other governmental authorities

                                       -19-


<PAGE>


pertaining to the protection of human health and safety or the environment,
now existing or later adopted during the term of this Lease.  As used in this
Lease, "Permitted Activities" shall mean laboratory, production, manufacturing,
general office and warehouse uses for developing manufacturing and
distributing biotechnology and/or pharmaceutical products or such other uses to
which Landlord shall reasonably consent in writing.  As used in this Lease,
"Permitted Materials" shall mean the materials handled by Tenant in the
ordinary course of conducting Permitted Activities.

      (b)  Tenant hereby agrees that:  (a) Tenant shall not conduct, or
permit to be conducted, on the Premises any activity which is not a Permitted
Activity; (b) Tenant shall not use, store or otherwise handle, or permit any
use, storage or other handling of, any Hazardous Material which is not a
Permitted Material on or about the Premises; (c) Tenant shall obtain and
maintain in effect all permits and licenses required pursuant to any
Environmental Law for Tenant's activities on the Premises, and Tenant shall at
all times comply with all applicable Environmental Laws; (d) Tenant shall not
engage in the storage, treatment or disposal on or about the Premises of any
Hazardous Material except for any temporary accumulation of waste generated in
the course of Permitted Activities; (e) Tenant shall not install any aboveground
or underground storage tank or any subsurface lines for the storage or transfer
of any Hazardous Material, except for the lawful discharge of waste to the
sanitary sewer, and Tenant shall store all Hazardous Materials in a manner that
protects the Premises, the Property and the environment from accidental spills
and releases; (f) Tenant shall not cause or permit to occur any release of any
Hazardous Material or any condition of pollution or nuisance on or about the
Premises, whether affecting surface water or groundwater, air, the land or the
subsurface environment; (g) Tenant shall promptly remove from the Premises any
Hazardous Material introduced, or permitted to be introduced, onto the Premises
by Tenant which is not a Permitted Material and, on or before the date Tenant
ceases to occupy the Premises, Tenant shall remove from the Premises all
Hazardous Materials and all Permitted Materials handled by or permitted on the
Premises by Tenant; and (h) if any release of a Hazardous Material to the
environment, or any condition of pollution or nuisance, occurs on or about or
beneath the Premises as a result of any act or omission of Tenant or its agents,
officers, employees, contractors, invitees or licensees, Tenant shall, at
Tenant's

                                       -20-


<PAGE>



sole cost and expense, promptly undertake all remedial measures required to
clean up and abate or otherwise respond to the release, pollution or nuisance
in accordance with all applicable Environmental Laws.  Landlord and Landlord's
representatives shall have the right, but not the obligation, to enter the
Premises at any reasonable time for the purpose of inspecting the storage,
use and handling of any Hazardous Material on the Premises in order to
determine Tenant's compliance with the requirements of this Lease and applicable
Environmental Law.  If Landlord gives written notice to Tenant that Tenant's
use, storage or handling of any Hazardous Material on the Premises may not
comply with this Lease or applicable Environmental Law, Tenant shall correct any
such violation within five (5) days after Tenant's receipt of such notice from
Landlord.  Tenant shall indemnify and defend Landlord against and hold Landlord
harmless from all claims, demands, actions, judgments, liabilities, costs,
expenses, losses, damages, penalties, fines and obligations of any nature
(including reasonable attorneys' fees and disbursements incurred in the
investigation, defense or settlement of claims) that Landlord may incur as a
result of, or in connection with, claims arising from the presence, use,
storage, transportation, treatment, disposal, release or other handling, on or
about or beneath the Premises, of any Hazardous Material introduced or permitted
on or about or beneath the Premises by any act or omission of Tenant or its
agents, officers, employees, contractors, invitees or licensees.  The liability
of Tenant under this paragraph 22 shall survive the termination of this Lease
with respect to acts or omissions that occur before such termination.

     (c)  Landlord shall not cause or permit to occur any release of any
Hazardous Material or any condition of pollution or nuisance on or about the
Premises, whether affecting surface water or groundwater, air, the land or the
subsurface environment.  Landlord shall promptly remove from on or about the
Premises any Hazardous Material introduced, or permitted to be introduced, onto
the Premises by Landlord.  If any release of a Hazardous Material into the
environment, or any condition of pollution or nuisance, occurs on or about or
beneath the Premises as a result of any act or omission of Landlord or its
agents, officers, employees, contractors, invitees or licensees, Landlord shall,
at Landlord's sole cost and expense, promptly undertake all remedial measures
required to clean up and abate or otherwise respond to the release, pollution or
nuisance in accordance with all applicable Environmental Laws.  Landlord

                                       -21-


<PAGE>



shall indemnify and defend Tenant against and hold Tenant harmless from all
claims, demands, actions, judgments, liabilities, costs, expenses, losses,
damages, penalties, fines and obligations of any nature (including reasonable
attorneys' fees and disbursements incurred in the investigation, defense or
settlement of claims) that Tenant may incur as a result of, or in connection
with, claims arising from the presence, use, storage, transportation, treatment,
disposal, release or other handling, on or about or beneath the Premises, of any
Hazardous Material introduced or permitted on or about or beneath the Premises
by any act or omission of Landlord or its agents, officers, employees,
contractors, invitees or licensees.  The liability of Landlord under this
paragraph 22 shall survive the termination of this Lease with respect to acts
or omissions that occur before such termination.

     23.   ALTERATIONS.  Except for non-structural alterations costing less than
fifty thousand dollars ($50,000), Tenant shall not alter the Premises without
the prior written consent of Landlord, which consent shall not be unreasonably
withheld.  Within thirty (30) days of the completion of any alterations,
additions and improvements, Tenant shall deliver as-built plans to Landlord for
such alterations, additions and/or improvements.  Tenant shall not be required
to remove any alterations, additions, improvements or Trade Fixtures upon the
expiration or earlier termination of the Lease.

      24.  PROPERTY OF LANDLORD.  All repairs, improvements, changes,
alterations, equipment, Trade Fixtures, and machinery made or installed by
Tenant (collectively, "Alterations") shall immediately upon completion or
installation thereof be and become the property of Tenant throughout the Lease
term.  At the end of the Lease term, all repairs, improvements, changes,
alterations, equipment and machinery, except for furniture, fixtures, equipment
and Trade Fixtures which Tenant elects to remove, shall become the property of
Landlord.

      25.  DAMAGE OR DESTRUCTION.  Subject to the other provision of this
paragraph, if the Premises or any portion thereof becomes damaged or wholly or
partially untenantable because of fire, earthquake, act of God, the elements or
other casualty, Landlord shall repair such damage at Landlord's sole cost and
expense provided insurance proceeds payable with respect to such loss are equal
to or greater than seventy-five percent (75%) of the cost to repair such damage
or destruction.  Landlord shall

                                       -22-


<PAGE>


notify Tenant within thirty (30) days after the date the loss occurs of the
estimated cost to repair such damage or destruction and whether such damage or
destruction may be repaired within one hundred and fifty (150) days of the date
such loss occurred ("Landlord's Damage Notice"). If the insurance proceeds
payable with respect to such loss are less than seventy-five percent (75%) of
the cost to repair such damage or destruction, Landlord may elect to terminate
this Lease upon written notice to Tenant given within ten (10) days following
receipt of Landlord's Damage Notice.  If Landlord estimates the repairs will
take more than one hundred fifty (150) days from the date the loss occurred,
either Landlord or Tenant may elect to terminate this Lease upon written notice
to the other given within ten (10) days following receipt of Landlord's Damage
Notice.  If neither Landlord nor Tenant elect to terminate this Lease, then
Landlord shall restore the damage or destruction at Landlord's sole expense
within one hundred fifty (150) days after the date the loss occurred.
If Landlord fails to substantially complete the restoration of such damage or
destruction within one hundred fifty (150) days following such damage or
destruction, Tenant may elect to terminate this Lease by giving written notice
of such election to Landlord not later than the one hundred eightieth (180th)
day following the date the loss occurred.  Rent shall abate for such part of
the Premises as shall be rendered unusable by Tenant in the conduct of its
business during the time such part is so unusable.

    26.   WAIVER.  Tenant hereby waives California Civil Code Sections 1932,
1933, 1941 and 1942 and the provisions of any other law now or hereafter in
effect that would relieve Tenant from any obligation to pay rent under this
Lease except to the extent expressly provided in this Lease.

    27.   CONDEMNATION.

    (a)   If the Premises or any portion thereof are taken under the power
of eminent domain (hereinafter referred to as "Condemnation"), this Lease shall
terminate as to the part so taken as of the date the condemning authority takes
title or possession, whichever occurs first.  If more than fifty percent (50%)
of the floor area of the Premises is taken by Condem-nation, then at Tenant's
option, exercisable only in writing and within ten (10) days after Landlord
shall have given Tenant written notice of such taking (or, in the absence of
such notice, within ten (10) days after the condemning authority

                                       -23-


<PAGE>


shall have taken possession), and provided that Tenant is not in default under
this Lease, Tenant may terminate this Lease as of the date the condemning
authority takes possession.  If Tenant does not terminate this Lease in
accordance with the foregoing, this Lease shall remain in full force and effect
as to the portion of the Premises remaining, except that the rent shall be
reduced in the proportion that the floor area of the portions of the Premises
taken bears to the total floor area of the Premises at the time of the taking.
No reduction of rent shall occur if no portion of the area taken contains any
portion of the Premises.  Notwithstanding the foregoing, if more than ten
percent (10%) of the parking spaces allocated to Tenant are taken, within sixty
(60) days after such taking, Landlord shall provide alternative parking spaces
to replace those parking spaces taken by Condemnation at a location reasonably
acceptable to Tenant.  If Landlord fails to deliver such parking spaces within
such sixty (60) day period, Tenant may elect to terminate the Lease by giving
written notice to Landlord within thirty (30) days of the expiration of such
sixty (60) day period.

       (b)   In the event any portion of the Premises is taken by Condemnation,
Landlord shall be entitled to and shall receive the total award  made in such
Condemnation, which award Tenant hereby assigns to Landlord, except that Tenant
shall be entitled to receive such portion of the award as may be specifically
allocated in such proceedings as compensation for Tenant's Trade Fixtures, the
unamortized benefit of those improvements made at Tenant's sole cost and
expense, and Tenant's relocation expenses.

        (c)   If less than the entire Premises shall be taken by Condemnation,
and this Lease is not terminated pursuant to subparagraph (a) above, with the
net amount of any award for severance damages received by Landlord in any
proceeding for physical damage to the Building Landlord shall promptly restore
that portion of the Building not so taken to a complete architectural unit.

         28. TENANT'S WORK.  All work done by Tenant in or about the Premises
(hereinafter called the "Work") shall be done in all cases subject to the
following conditions, each of which Tenant covenants to observe and perform:

         (a) No Work involving any structural change and no Work involving any
alteration, restoration, or rebuilding costing

                                       -24-


<PAGE>


more than fifty thousand dollars ($50,000) shall be undertaken until detailed
plans and specifications have first been submitted to and approved in writing
by Landlord;

          (b)  No Work involving a cost, as reasonably estimated by Tenant, of
more than fifty thousand dollars ($50,000) shall be undertaken except under the
supervision of an architect or engineer approved in writing by Landlord (unless
such requirement is waived by Landlord in writing), which approval shall not be
unreasonably withheld;

          (c)  All Work shall be (i) commenced only after reasonable notice to
Landlord and only after all required local and other governmental permits and
authorizations have been obtained, (ii) done in a good and workmanlike manner,
(iii) performed in compliance with the building and zoning laws and with all
other applicable Laws and in accordance with the recommendations of any insurer
under any policies required by this Lease, and (iv) completed promptly and free
of liens; and

          (d)   If Landlord shall so elect, for Work that costs in excess of
fifty thousand dollars ($50,000), Tenant shall pay to Landlord a fee of one
thousand dollars ($1,000) to review any plans for Work or to monitor Tenant's
performance of any Work.

          29.   MECHANIC'S LIENS.  Tenant shall not suffer or permit any
mechanics' or other liens (or claims thereof) to be filed against the Premises
or Tenant's leasehold interest therein or hereunder by reason of work, labor,
services, or materials supplied or claimed to have been supplied to Tenant or
anyone holding the Premises or any part thereof through or under Tenant.
Landlord shall have the right at all reasonable times to post and keep posted
on the Premises any notices that Landlord may deem necessary or advisable for
the protection of Landlord and the Premises from mechanics' liens.  If any such
liens (or claims thereof) shall at any time be filed against the Premises,
Tenant shall cause the same to be discharged of record within forty-five
(45) days after the date of filing.

           30.  FINANCIAL STATEMENTS.  Upon the request of Landlord, Tenant
shall provide to Landlord from time to time, at no expense to Landlord, copies
of such quarterly financial statements with respect to Tenant as are required
to be filed with the Securities Exchange Commission.

                                       -25-


<PAGE>

       31.   LANDLORD'S ENTRY.  Tenant agrees to permit Landlord and any
authorized representatives of Landlord to enter the Premises with reasonable
frequency during usual business hours, or at any other time in case of
emergency, (a) to inspect the Premises and, if Landlord so desires, but without
implying any obligation of Landlord to do so, to make any repairs deemed
necessary or desirable by Landlord and to perform any work in the Premises
deemed necessary by Landlord to comply with any Laws or the recommendations of
any insurer, and (b) during the final nine (9) months of the term of this Lease,
for the purpose of leasing the Premises, during which nine (9) month period
Landlord may display on the Premises, in such manner as not to interfere
unreasonably with Tenant's business, usual "For Sale" or "To Let" signs.

        32.   ASSIGNMENT AND SUBLETTING.

        (a)   Tenant shall not hypothecate or encumber this Lease or any
interest herein without the prior written consent of Landlord, which may be
granted or denied in Landlord's absolute discretion.  Tenant shall not, without
the prior consent of Landlord, which consent shall not be unreasonably withheld
by Landlord, transfer or assign this Lease or any interest herein, sublet the
Premises or any part thereof, or permit the use of the Premises by any party
other than Tenant.  This Lease shall not, nor shall any interest herein, be
assignable as to the interest of Tenant by operation of law without the consent
of Landlord, which consent shall not be unreasonably withheld.  Any of the
foregoing acts without such consent shall be void and shall, at the option of
Landlord, terminate this Lease.  In connection with each consent requested by
Tenant, Tenant shall submit to Landlord the terms of the proposed transaction,
the identity of the parties to the transaction, the proposed documentation for
the transaction, and all other information reasonably requested by Landlord
concerning the proposed transaction and the parties involved.

        (b)   Notwithstanding anything to the contrary contained herein, Tenant
may assign this Lease at any time, without Landlord's prior consent, to any
entity that acquires all or substantially all of Tenant's stock in a merger or
consolidation, or that is acquired in whole by Tenant, or that acquires all or
substantially all of the assets of Tenant (each an "Affiliate").  Within five
(5) days of the assignment to an

                                       -26-


<PAGE>


Affiliate, Tenant shall give Landlord written notice of such assignment.

         (c)   Without limiting the other instances in which it may be
reasonable for Landlord to withhold its consent to an assignment or subletting,
Landlord and Tenant acknowledge that it shall be reasonable for Landlord to
withhold its consent in the following instances:

         (i)  if at the time consent is requested or at any time prior to the
granting of consent, Tenant is in default under this Lease or would be in
default under this Lease but for the pendency of any grace or cure period
specified in this Lease;

        (ii)  if the proposed assignee or sublessee is a governmental agency,
except government agencies related to university research or hospitals;

       (iii)  if, in Landlord's reasonable judgment, the use of the Premises
by the proposed assignee or sublessee would involve occupancy in violation of
this Lease; or

        (iv)  if, in Landlord's reasonable judgment, the financial worth of the
proposed assignee or sublessee does not meet the current credit standards
applied by Landlord or its investment advisors for a new tenant of the Premises.

         (d)  If at any time during the term of this Lease Tenant desires to
assign its interest in this Lease or sublet all or any part of the Premises,
Landlord shall have a right to negotiate with Tenant for an assignment or
sublease.  Tenant shall give notice to Landlord of its intention to assign or
sublet ("Tenant's Offer").  If Landlord wishes to become a subtenant or assignee
of Tenant, Landlord shall notify Tenant within twenty (20) days after the giving
of Tenant's Offer, whereupon Landlord and Tenant shall negotiate in good faith
during the next twenty (20) day period to arrive at an agreement as to the terms
of such assignment or subletting.  If Landlord and Tenant do not reach agreement
on the terms of an assignment or subletting within said forty (40) day period
following the giving of Tenant's Offer ("Landlord's Negotiation Period"), then
Tenant shall be free for a period of one hundred twenty (120) days following the
end of the Landlord's Negotiation Period to assign its entire interest in this
Lease or to sublet such space as set forth in Tenant's Notice on such terms as
Tenant may

                                       -27-


<PAGE>


desire; provided that Tenant shall give notice to Landlord setting
forth the terms of the specific proposed assignment or sublet ("Tenant's
Notice').  Within thirty (30) days of giving the Tenant's Notice, Landlord shall
either (i) consent to the assignment in which event the provisions of
subparagraph (g) shall be applicable, or consent to the subletting in which
event the provisions of subparagraph (h) shall be applicable, or (ii) notify
Tenant in writing of the grounds upon which Landlord is withholding consent.

      (e)  Notwithstanding the provisions of subparagraphs (a) and (b)
above, Tenant may assign this Lease or sublet the Premises or any portion
thereof, with prior notice to Landlord but without the necessity of Landlord's
consent and without extending any option to Landlord pursuant to
subparagraph (d) above, to any Affiliate (as defined herein).

      (f)  No sublessee (other than Landlord if it so negotiates pursuant to
subparagraph (d) above) shall have a right further to sublet without Landlord's
prior consent, which Tenant acknowledges may be withheld in Landlord's absolute
discretion, and any assignment by a sublessee of its sublease shall be subject
to Landlord's prior consent in the same manner as if Tenant were entering into a
new sublease.  No sublease, once consented to by Landlord, shall be modified or
terminated by Tenant without delivering notice of such modification or
termination to Landlord within ten (10) days of the execution of such
modification or termination.

      (g)  In the case of an assignment to an entity other than Landlord,
fifty percent (50%) of any sums or other economic consideration received by
Tenant as consideration for such assignment shall be paid to Landlord after
first deducting (1) the rental due hereunder, paid to Tenant, if any, (2) the
cost of leasehold improvements made to the Premises, and (3) the cost of any
real estate commissions, marketing and other costs (including rent concessions),
incurred by Tenant in connection with such assignment.

       (h)  In the case of a subletting to an entity other than Landlord,
fifty percent (50%) of any sums or economic consideration received by Tenant as
a result of such subletting shall be paid to Landlord after first deducting
(1) the rental due hereunder, prorated to reflect only rental allocable to the
sublet portion of the Premises, (2) the cost of leasehold

                                       -28-


<PAGE>


improvements made to the sublet portion of the Premises at Tenant's sole cost,
amortized over the term of this Lease except for leasehold improvements made by
Tenant for the specific benefit of the sublessee, which shall be amortized over
the term of the sublease, and (3) the cost of any real estate commissions,
marketing and other costs (including rent concessions), incurred by Tenant in
connection with such subletting, amortized over the term of the sublease.

       (i)  Regardless of Landlord's consent, no subletting or assignment
(except to Landlord pursuant to the provisions of subparagraph (d) above) shall
release Tenant of Tenant's obligation or alter the primary liability of Tenant
to pay the rent and to perform all other obligations to be performed by Tenant
hereunder.  The acceptance of rent by Landlord from any other person shall not
be deemed to be a waiver by Landlord of any provision hereof.  Consent to one
assignment or subletting shall not be deemed consent to any subsequent
assignment or subletting.  In the event of default by any assignee of Tenant or
any successor of Tenant in the performance of any of the terms hereof, Landlord
may proceed directly against Tenant without the necessity of exhausting remedies
against such assignee or successor.  Landlord may consent to subsequent
assignments or subletting of this Lease without notifying Tenant, or any
successor of Tenant, and without obtaining its or their consent thereto, and
such action shall not relieve Tenant of liability under this Lease.

       (j)  In the event Tenant shall assign this Lease or sublet the
Premises or request the consent of Landlord to any assignment, subletting,
hypothecation or other action requiring Landlord's consent hereunder, then
Tenant shall pay Landlord's then reasonable and standard processing fee and
Landlord's reasonable attorneys' fees incurred in connection therewith, which
shall not exceed one thousand dollars ($1000).

       33.  SUBORDINATION.  At Landlord's option, this Lease shall be
subordinate to any ground lease, mortgage, deed of trust, or any other
hypothecation or security now or hereafter placed upon the Premises and to any
and all advances made on the security thereof and to all renewals,
modifications, consolidations, replacements, and extensions thereof; provided
such ground lessor, mortgagee or trustee shall have entered into a written
agreement with Tenant not to disturb Tenant's possession of the Premises as
long as Tenant is not in default under the Lease.

                                       -29-


<PAGE>


Notwithstanding such subordination, Tenant's right to a quiet possession of the
Premises shall not be disturbed if Tenant is not in default and so long as
Tenant shall pay the rent and observe and perform all of the provisions of this
Lease, unless this Lease is otherwise terminated pursuant to its terms.  If any
mortgagee, trustee, or ground lessor shall elect to have this Lease prior to the
lien of its mortgage, deed of trust, or ground lease, and shall give written
notice thereof to Tenant, this Lease shall be deemed prior to such mortgage,
deed of trust, or ground lease, whether this Lease is dated prior or subsequent
to the date of such mortgage, deed of trust, or ground lease or the date of the
recording thereof.

     34.   ATTORNMENT.  In the event any proceedings are brought for the
foreclosure of, or in the event of exercise of the power of sale under, any
mortgage or deed of trust now or hereafter on the Premises or any part thereof,
Tenant shall, if so requested by the purchaser upon such foreclosure or sale or
the grantee under a deed in lieu of foreclosure, attorn to such purchaser or
grantee and recognize such purchaser or grantee as the Landlord under this
Lease.

     35.   INDEMNIFICATION.  Tenant agrees to indemnify, defend, and save
Landlord harmless from and to reimburse Landlord for any and all claims arising
from (a) the conduct or management of, or any work or thing whatsoever done in
or about, the Premises during the term of this Lease, (b) any condition caused
by Tenant existing during the term of this Lease of (i) the Premises, (ii) any
street, curb, or sidewalk adjoining the Premises, or (iii) any vaults,
passageways, or spaces therein or appurtenant thereto, (c) any breach or default
on the part of Tenant in the performance of any covenant or agreement on the
part of Tenant to be performed pursuant to the terms of this Lease, (d) any act
or negligence of Tenant or any of its agents, contractors, servants, employees,
or licensees, (e) any accident, injury, or damage whatsoever caused by Tenant to
any person, firm, or corporation occurring during the term of this Lease in or
about the Premises or upon or under the sidewalks or the land adjacent thereto,
and (f) any and all costs, counsel fees, expenses, and liabilities incurred in
connection with the such claim or action or proceeding brought thereon, except
to the extent that any of the above-described claims arise out of any negligence
or willful misconduct of Landlord.  In case any action or proceeding be brought
against Landlord by reason of any such claim, Tenant, upon notice from Landlord,
covenants to

                                       -30-


<PAGE>


resist or defend such action or proceeding by counsel satisfactory to Landlord.

     36.   ATTORNEYS' FEES.  If any action arising in any manner whatsoever out
of this Lease is brought by either party hereto against the other, then and in
that event the unsuccessful party to such action shall pay to the prevailing
party all costs and expenses, including reasonable attorneys' fees, incurred by
such prevailing party, and if the prevailing party shall recover judgment in
such action, such costs, expenses and attorneys' fees shall be included in and
as part of such judgment.

     37.   LANDLORD REPRESENTATIONS.  Landlord shall deliver the Main Premises
to tenant clean and free of debris on the Commencement Date, and Landlord hereby
represents to Tenant that (i) the roof, plumbing, sewer, electrical and HVAC
systems are all in good working order on the Commencement Date, and (ii) there
are no Hazardous Materials except as disclosed to Tenant present in, on, or
under the Premises.

     38.   EVENTS OF DEFAULT.  The following events shall be deemed to be events
of default by Tenant under this Lease:

     (a)   The failure of Tenant to pay any installments of Base Rent or
additional rent or any other payment or reimbursement to Landlord required
herein when due, except that upon Tenant's first such default in any given
calendar year, such default shall not be considered an event of default until
Landlord has given Tenant notice of such default, and Tenant shall have failed
to cure such default for ten (10) days following the delivery of such notice;

     (b)   (i) The application by Tenant for consent to the appointment of a
receiver, trustee, or liquidator of Tenant or of all or a substantial part of
Tenant's assets, (ii) Tenant's insolvency or admission in writing of its
inability to pay its debts as they come due, (iii) the making by Tenant of any
general arrangement or assignment for the benefit of creditors, (iv) Tenant
becomes a "debtor" as defined in 11 U.S.C. Section 101 or any successor statute
thereto (unless, in the case of a petition filed against Tenant, the same is
dismissed within sixty (60) days), (v) the appointment of a trustee or receiver
to take possession of all or substantially all of Tenant's assets located at the
Premises or of Tenant's interest in this Lease (unless possession is restored to
Tenant within thirty

                                       -31-


<PAGE>


(30) days), (vi) the attachment, execution, or other judicial seizure of all or
substantially all of Tenant's assets located at the Premises or of Tenant's
interest in this Lease (unless such seizure is discharged within thirty
(30) days), or (vii) any transfer of Tenant's assets in fraud of its
creditors; or

      (c)  The failure of Tenant to comply with any other term, provision,
or covenant of this Lease, where such failure shall continue for a period of
thirty (30) days after written notice thereof to Tenant, provided, however, that
if such failure cannot reasonably be cured within thirty (30) days, Tenant shall
not be deemed in default with respect to such failure if Tenant commences to
cure such default within said thirty (30) day period and thereafter diligently
and continuously prosecutes such cure to a prompt completion.  In the event
Landlord serves Tenant with a "Notice to Perform or Quit" pursuant to applicable
unlawful detainer statutes, such notice shall also constitute the notice
required by this subsection, provided that such notice gives Tenant at least
thirty (30) days in which to perform or quit.

      39.  LANDLORD'S REMEDIES.  Upon the occurrence of any event of default by
Tenant, Landlord may, at its option and without any further notice or demand (in
addition to any other rights and remedies under this Lease, at law or in equity)
do any of the following:

      (a)  Landlord shall have the right, so long as such default continues,
to give notice of termination to Tenant.  On the date specified in such notice
(which shall not be less than three (3) days after the giving of such notice)
this Lease shall terminate;

      (b)  In the event of any such termination of this Lease, Landlord may
then or at any time thereafter re-enter the Premises and remove therefrom all
persons and property and again repossess and enjoy the Premises, without
prejudice to any other remedies that Landlord may have by reason of Tenant's
default or of such termination;

      (c)  In the event of any such termination of this Lease, Landlord may
recover damages which shall include, without limitation:  (1) the amount at the
time of award computed by discounting such amount at the discount rate of the
Federal

                                       -32-


<PAGE>



Reserve Bank of San Francisco at the time of award plus one percent) of
(A) unpaid rent earned at the time of termination, (B) the amount by which the
unpaid rent that would have been earned during the period from termination until
the award exceeds the amount of such rental loss that Tenant proves could have
been reasonably avoided, and (C) the amount by which the unpaid rent for the
balance of the term after the time of award exceeds the amount of such rental
loss that Tenant proves could be reasonably avoided; (2) all legal expenses and
other related costs incurred by Landlord following Tenant's default; (3) all
costs incurred by Landlord in restoring the Premises to good order and
condition, or, to the extent reasonably necessary to accomplish such reletting,
in remodeling, renovating, or otherwise preparing the Premises for reletting;
and (4) all other costs (including without limitation any brokerage commissions)
incurred by Landlord in reletting the Premises; provided that in no event shall
Landlord recover more damages than those reasonably necessary to make Landlord
whole;

      (d)   Following the termination of this Lease (or upon Tenant's failure
to remove its personal property from the Premises after the expiration of the
term of this Lease), Landlord may remove any and all personal property located
in the Premises and sell or place such property in a public or private warehouse
or elsewhere at the sole cost and expense of Tenant in accordance with
applicable Laws.  Tenant waives all claims for damages that may be caused by
Landlord's removing, storing or selling the property as herein provided;

      (e)   Landlord shall have the right to cause a receiver to be appointed
in any action against Tenant to take possession of the Premises and to collect
the rents or profits derived therefrom.  The appointment of such receiver shall
not constitute an election on the part of Landlord to terminate this Lease
unless notice of such intention is given to Tenant; or

      (f)   Landlord shall have the remedy described in California Civil Code
Section 1951.4 (i.e. Landlord may continue this Lease in effect after Tenant's
abandonment and recover rent as it becomes due, because Tenant has the right to
sublet or assign, subject only to reasonable limitations).  Even though Tenant
has breached this Lease and abandoned the Premises, this Lease shall continue in
effect for so long as Landlord does not terminate Tenant's right to possession,
and Landlord may enforce all its rights and remedies under this Lease, including
the right to

                                       -33-


<PAGE>



recover rent in periodic actions as it becomes due under this Lease.  In such
event, Landlord may re-enter the Premises and remove all persons and property
if the Premises have not been vacated, using any available summary proceedings,
without such re-entry or removal being deemed a termination or acceptance of
surrender of this Lease.  Landlord may then elect to relet the Premises for the
account of Tenant for a period that may extend beyond the term hereof, and upon
such other terms as Landlord may reasonably deem appropriate.  Tenant shall
reimburse Landlord upon demand for all costs incurred by Landlord in connection
with such reletting, including without limitation necessary restoration,
renovation, or improvement costs, attorneys' fees, and brokerage commissions.
The proceeds of such reletting shall be applied first to any sums then due and
payable to Landlord from Tenant, including the reimbursement described above.
The balance, if any, shall be applied to the payment of future rent as it
becomes due hereunder.  In no event shall Landlord receive damages in excess
of those reasonably necessary to make Landlord whole.

     40.   CUMULATIVE REMEDIES.  The specified remedies to which Landlord may
resort under the terms of this Lease are cumulative and are not intended to be
exclusive of any other remedies or means of redress to which Landlord may be
entitled, either at law or in equity, in case of any breach or threatened breach
by Tenant of any covenant, agreement, or condition of this Lease.

     41.   NO WAIVERS.  The failure of Landlord to insist in any one or more
instances upon the strict performance or observance of any of the covenants,
agreements, or conditions of this Lease or to exercise any option herein
contained shall not be construed as a waiver or a relinquishment of future
performance or observance of such covenant, agreement, or condition or exercise
of such option.

     42.   APPLICATION OF TENANT DEPOSITS.  In the event of any default by
Tenant under this Lease, Landlord may, at its option, apply on account of such
default any monies (and the proceeds of any and all other security) deposited by
or for the account of Tenant under any provision of this Lease.  Tenant shall
not be entitled to interest on any monies so deposited.

     43.   HOLDING OVER.  Tenant covenants that it will vacate the Premises
immediately upon the expiration or sooner termination of this Lease.  If, with
Landlord's written consent,

                                       -34-


<PAGE>


Tenant retains possession of the Premises or any part thereof after the
expiration or termination hereof, Tenant shall pay Landlord rent at one
hundred twenty-five percent (125%) of the monthly rate of Base Rent
specified in paragraph 3 for the time Tenant thus remains in possession.
In all other cases, if Tenant retains possession of the Premises or any
part thereof after the expiration or termination hereof, Tenant shall pay
Landlord rent at one hundred fifty percent (150%) of the monthly rate of Base
Rent specified in paragraph 3 for the time Tenant thus remains in possession. 
The provisions of this paragraph do not exclude Landlord's rights of re-entry or
any other right hereunder, including without limitation the right to refuse one
hundred fifty percent (150%) of the monthly rate of Base Rent and instead to
remove Tenant through summary proceedings for holding over beyond the expiration
of the term of this Lease.

     44.  NOTICES.  All notices, demands, and requests that may or are required
to be given by either party to the other shall be in writing and shall be deemed
given when sent-by United States Certified Mail, postage prepaid, and addressed
as follows:  (a) to Tenant at the address specified in the Basic Lease
Information, or at such other place as Tenant may from time to time designate by
written notice to Landlord, or (b) to Landlord at the address specified in the
Basic Lease Information, or at such other places as Landlord may from time to
time designate by written notice to Tenant.

     45.  LIMITATION OF LANDLORD'S LIABILITY.  In the event of a sale or
transfer by Landlord of its interest in the Premises or this Lease and the
transferee's written assumption of Landlord's obligations, such sale or transfer
shall operate to release the transferor from all liability for the performance
of the obligations of Landlord hereunder, expressed or implied, from and after
the date of such transfer, and Tenant agrees thereafter to look solely to the
successor in interest of Landlord in and to this Lease for the performance
thereafter of Landlord's obligations hereunder; provided, however, Landlord
shall not be relieved of its obligations pursuant to paragraphs 52(f) and (g)
until such obligation has been fully performed by Landlord or such transferee. 
Landlord may transfer to its successor in interest the Security Deposit (and all
other forms of security) given by or for Tenant to Landlord and thereupon
Landlord shall be discharged from any further liability with respect thereto.

                                     -35-
<PAGE>

     46.  ESTOPPEL CERTIFICATES.  At any time and from time to time upon not
less than ten (10) days prior request by Landlord, Tenant agrees to execute,
acknowledge, and deliver to Landlord a statement in writing certifying that
(a) this Lease is unmodified and in full force and effect (or if there have been
modifications, that the same is in full force and effect as modified and
identifying the modifications), (b) the dates to which Base Rent, additional
rent, and other charges have been paid, and (c) whether there is then existing
any claim by Tenant of default hereunder by Landlord and, if so, specifying the
nature thereof.  Failure by Tenant to execute, acknowledge and deliver such an
estoppel certificate within such ten (10) day period shall be conclusive
evidence that (i) the Lease is unmodified and in full force and effect,
(ii) Tenant has not prepaid more than one (1) month of Base Rent, additional
rent, and other charges, and (iii) Tenant has no claim of default hereunder by
Landlord.  It is intended that any such statement or failure to deliver such a
statement may be relied upon by any person proposing to acquire Landlord's
interest in this Lease or any prospective mortgagee of, or assignee of any
mortgage upon, such interest.

     47.  BROKERAGE.  Tenant represents and warrants that it has dealt with no
broker, agent, or other person in connection with this transaction and that no
other broker, agent, or other person brought about this transaction, other than
the Brokers listed in the Basic Lease Information, and Tenant agrees to
indemnify and hold Landlord harmless from and to reimburse Landlord for any and
all claims by any other broker, agent, or person claiming a commission or other
form of compensation by virtue of having dealt with Tenant with respect to this
leasing transaction.  The provisions of this paragraph shall survive the
termination of this Lease.

     48.  SECURITY DEPOSIT.  Tenant shall, upon execution of this Lease, deposit
with Landlord the sum specified in the Basic Lease Information as security for
the full and faithful performance of every provision of this Lease to be
performed by Tenant (the "Security Deposit").  If Tenant defaults with respect
to any provision of this Lease, Landlord may use, apply, or retain all or any
part of the Security Deposit for the payment of Base Rent or any other sum in
default, for the payment of any other amount that Landlord may spend or become
obligated to spend by reason of Tenant's default, or to compensate Landlord for
any other loss, cost, or damage that

                                       -36-


<PAGE>


Landlord may suffer by reason of Tenant's default, and if Tenant so defaults at
least three (3) times, Landlord may require Tenant to deposit cash with Landlord
to increase the Security Deposit up to a sum no greater than two (2) times the
then current Base Rent.  If any portion of the Security Deposit is so used or
applied, Tenant shall, within five (5) days after written demand therefor,
deposit cash with Landlord in an amount sufficient to restore the Security
Deposit to the amount required by Landlord as allowed under this paragraph 48.
Landlord shall not be required to keep the Security Deposit separate from its
general funds and Tenant shall not be entitled to interest on such deposit.

     49.  SIGNAGE.  Tenant shall not place or permit on the outside of the
Premises any sign, advertisement, illumination, projection, or similar thing (a
"Sign"), unless (a) Landlord has given its prior written consent thereto, which
shall not be unreasonably withheld, and (b) such Sign complies with applicable
law.  Notwithstanding the foregoing, provided that (i) Landlord gives Tenant
prior written consent, which consent will not be unreasonably withheld; and
(ii) Tenant complies with applicable laws, Tenant may install one sign with its
name and corporate logo on the Building and one sign with its name and corporate
logo in front of the Building.  Tenant must maintain and repair all Signs in a
first class condition.  Upon the expiration or earlier termination of this
Lease, Tenant shall remove all Signs installed by Tenant and repair all damage
caused by any such removal.

    50.  TERMINATION OPTION.  Tenant shall have the one time right to terminate
this Lease upon the last day of the sixtieth (60th) month of the Lease term by
delivering notice to Landlord of Tenant's option to terminate at least nine (9)
months prior to the end of the sixtieth (60th) month of the Lease term.  If
Tenant exercises its right to terminate this Lease, upon delivery of Tenant's
notice to terminate, Tenant shall pay to Landlord one hundred forty-four
thousand nine hundred dollars ($144,900) as a termination fee and any
unamortized Amortized Costs (as defined in paragraph 52(g)).

     51.  EXTENSION OPTION.

     (a)  If Tenant or an Affiliate directly occupies at least seventy-five
percent (75%) of the Premises upon the last day of the Lease term, Tenant shall
have the option to renew this Lease

                                       -37-


<PAGE>



for one (1) additional sixty (60) month term (the "Extended Term"), by
delivering notice to Landlord of Tenant's option to extend the term of this
Lease.  If Tenant exercises its right to extend, the term of this Lease shall
be extended for the applicable sixty (60) month period, and Tenant shall
continue to lease the Premises on all of the terms and conditions of this
Lease, except that (i) the Base Rent payable by Tenant during the Extended Term
shall be the fair market rent as determined in paragraph 51(b) or
paragraph 51(c) hereof; and (ii) Tenant shall have no further renewal options
under this Lease.  Notwithstanding the foregoing, if an event of default by
Tenant exists on the first day of the Extended Term, this Lease shall
automatically terminate, and Tenant shall be deemed to have elected not to
exercise its renewal option.

     (b)  If Tenant exercises the right to extend the term of this Lease
for the Extended Term in accordance with paragraph 51(a) hereof, effective as of
first day of the Extended Term, the Base Rent shall be ninety-five percent (95%)
of the prevailing fair market rental value of the Premises on the first day of
the Extended Term, on and subject to the agreements, covenants and conditions
(except the amount of Base Rent) of this Lease, based on then current rent being
offered and accepted for comparable space in comparable buildings in the San
Francisco Bay Area used by biotechnology companies for uses comparable to
Tenant's use of the Premises leased on terms comparable to this Lease as of the
first day of the Extended Term, expressly excluding any rental value added to
the Premises from alternations or improvements or Trade Fixtures paid for by
Tenant directly or through amortization in the rent.  Such fair market rental
value shall be determined by agreement between Landlord and Tenant.  If Landlord
and Tenant do not agree on such fair market rental value by the date three (3)
months prior to the first day of the Extended Term, such fair market rental
value shall be determined by appraisal in accordance with paragraph 51(c)
hereof.  Notwithstanding the foregoing, in no event shall the Base Rent during
the Extended Term be less than the Base Rent for the month immediately preceding
the Extended Term.  Landlord and Tenant each shall, promptly after the Base Rent
for the Extended Term has been determined pursuant to this paragraph 51(b) or
paragraph 51(c) hereof, execute and deliver to the other an amendment to this
Lease which sets forth the Base Rent during the Extended Term, but the Base Rent
so determined shall be effective during the Extended Term whether or not such
amendment is executed.

                                       -38-


<PAGE>



     (c)  For the purpose of paragraph 51 hereof, if Landlord and Tenant do
not agree on the fair market rental value of the Premises by the date three (3)
months prior to the first day of the Extended Term, such fair market rental
value shall be determined as follows:  Landlord and Tenant each shall appoint
one (1) appraiser within fifteen (15) days after a written request for
appointment of appraisers has been given by either Landlord or Tenant to the
other.  If either Landlord or Tenant fails to appoint its appraiser within such
period of fifteen (15) days, such appraiser shall be appointed by the Superior
Court of the State of California in and for the County of San Mateo upon
application of the other.  Each such appraiser shall appraise such fair market
rental value of the Premises and complete and submit his written appraisal
setting forth the appraised value to Landlord and Tenant within thirty (30) days
after the appointment of both such appraisers.  If the higher appraised value in
such two (2) appraisals is not more than one hundred ten percent (110%) of the
lower appraised value, such fair market rental value of the Premises shall be
the average of the two (2) appraised values.  If the higher appraised value is
more than one hundred ten percent (110%) of the lower appraised value, Landlord
and Tenant shall agree upon and appoint a neutral third appraiser within
fifteen (15) days after both of the first two (2) appraisals have been submitted
to Landlord and Tenant.  If Landlord and Tenant do not agree and fail to appoint
such neutral third appraiser within such period of fifteen (15) days, such
neutral third appraiser shall be appointed by the Superior Court of the State of
California in and for the County of San Mateo upon application of either
Landlord or Tenant.  The neutral third appraiser shall appraise such fair market
rental value of the Premises and complete and submit his written appraisal
setting forth the appraised value to Landlord and Tenant within thirty (30) days
after his appointment.  Such fair market rental value of the Premises shall be
the average of the two (2) appraised values in such three (3) appraisals that
are closest to each other.  The fair market rental value of the Premises,
determined in accordance with this paragraph 51(c), shall be conclusive and
binding upon Landlord and Tenant.  Any proceedings in connection with the
determination of the fair market rental value of the Premises shall be subject
to California Code of Civil Procedure sections 1280 to 1294.2 (including section
1283.05) or successor California laws then in effect relating to arbitration and
any such proceedings shall be conducted in the County of San Mateo.  All
appraisers appointed

                                       -39-


<PAGE>



by Landlord or Tenant, or both of them, shall be members of the American
Institute of Real Estate Appraisers of the National Association of Realtors
or real estate professionals qualified by appropriate training or experience
and have at least ten (10) years of experience dealing with commercial real
estate.  The appraisers shall have no power or authority to amend or modify
this Lease in any respect and their jurisdiction is limited accordingly.
Landlord and Tenant each shall pay the fee and expenses charged by its
appraiser plus one-half of the fee and expenses charged by the neutral third
appraiser.  If the fair market rental value of the Premises has not been
determined in accordance with this paragraph 51(c) by the first day of the
Extended Term, Tenant shall pay as Base Rent the average of the amount of Base
Rent proposed by Landlord and the amount of Base Rent proposed by Tenant, but
not less than the Base Rent for the month immediately preceding the Extended
Term, effective on the first day of the Extended Term, and Tenant shall continue
to pay such average until the fair market rental value of the Premises has been
determined, at which time any adjustment in the Base Rent resulting therefrom
shall be made retroactively within ten (10) days after such determination.

     52.  TENANT IMPROVEMENTS.

     (a)  Within the first year of the Lease term, Tenant shall have the
right to construct Improvements (as defined in paragraph 52(b) below) in the
Premises ("Tenant's Work"); provided that (i) Landlord gives its prior written
consent to all Tenant Plans (as defined in paragraph 52(c) below), construction
drawings and building materials for Tenant's Work, which consent shall not be
unreasonably withheld, and (ii) Tenant complies with all Laws respecting the
construction of the Improvements in the Premises.  Landlord may charge Tenant
one fee of one thousand dollars ($1,000) to review all Tenant Plans and manage
the construction of Tenant's Work.

     (b)  IMPROVEMENTS.  The term "Improvements" shall mean all improvements
shown in the Tenant Plans and, to the extent specified in the Tenant Plans, all
signage, partitions, built-ins, related cabinets, laboratory production and
manufacturing built-ins and fixtures, and all carpets and floor coverings,
electrical, heating, ventilation and air conditioning and plumbing work, gas and
air lines, ceiling plan and security plan.  Except as provided above, however,
Improvements shall not include any personal property of Tenant.  The "cost of
the

                                       -40-


<PAGE>


Improvements" means the entire cost of the design and construction of the
Improvements including, without limitation, all fees and costs of any designer,
engineer or contractor and any other consultants, and all permit fees and other
governmental costs and fees.

     (c)  Within the first six (6) months of the Lease term, Tenant shall
submit plans, working drawings and specifications ("Tenant Plans") to Landlord
for Landlord's written approval (which shall not be unreasonably withheld). 
Tenant Plans shall be prepared by qualified licensed architects and engineers
retained by Tenant and approved in writing by Landlord (which shall not be
unreasonably withheld), shall comply with all applicable codes, laws,
ordinances, rules and regulations, shall not adversely affect the Building shell
or core or any systems, components or elements of the Building, shall be in a
form sufficient to secure the approval of all government authorities with
jurisdiction over the Industrial Center, and shall be otherwise satisfactory to
Landlord in Landlord's reasonable discretion.  Tenant Plans shall be complete
plans, working drawings and specifications for the layout, improvement and
finish of the Premises consistent with the design and construction of the
Industrial Center, including mechanical and electrical drawings and decorating
plans.

     (d)  Tenant Plans shall be subject to Landlord's written approval (which
shall not be unreasonably withheld).  If Landlord disapproves the Tenant Plans,
or any portion thereof, Landlord shall promptly give notice to Tenant setting
forth the reasons for disapproval.  As promptly as reasonably possible
thereafter, but not later than five (5) business days after Landlord's notice,
Tenant shall submit to Landlord revised Tenant Plans.  Such revisions shall be
subject to Landlord's written approval (which shall not be unreasonably
withheld).

     (e)  The contractor ("Contractor") shall be selected by Tenant and
approved by Landlord in writing, which approval shall not be unreasonably
withheld.

     (f)  As Landlord's contribution for the costs of preparing the Tenant
Plans and performing Tenant's Work, Landlord shall give Tenant an allowance in
the amount of one hundred fifty thousand dollars ($150,000) ("Landlord's Initial
Contribution").  Landlord shall pay Landlord's Initial Contribution directly to
Tenant's architects, engineers and Contractor for the account of

                                       -41-


<PAGE>



Tenant, in installments as professional services for Tenant Plans are rendered
or Tenant's Work is performed, within ten (10) days after Landlord's receipt
from Tenant of a written request for payment accompanied by written invoices and
other written evidence reasonably satisfactory to Landlord showing the costs
incurred, until the earlier of the exhaustion of Landlord's Initial Contribution
or the last day of the twelfth (12th) month of the Lease term.

     (g)  If Tenant informs Landlord within six (6) months of the Commencement
Date that the cost of Tenant Plans and Tenant's Work will exceed Landlord's
Initial Contribution, Tenant may elect, from time to time, by written notice to
Landlord (the "Amortization Notice") received by Landlord to amortize a portion
of the cost of the Tenant Plans and Tenant's Work (but not to exceed three
hundred fifty thousand dollars ($350,000) (the "Amortized Costs") over the
portion of the Term beginning on the first day of the seventh (7th) month of the
Lease term and ending on the last day of the sixtieth (60th) month of the Lease
term, which Amortized Costs shall bear interest at the rate of nine percent (9%)
per annum during such portion of the Term.  Tenant shall pay to Landlord the
Amortized Costs and all interest thereon in equal monthly installments as
Additional Rent together with Tenant's payments of Base Rent.  Landlord shall
pay the Amortized Costs directly to Tenant's architects, engineers and
Contractor for the account of Tenant, in installments as professional services
for Tenant Plans are rendered or Tenant's Work is performed, upon Landlord's
receipt from Tenant of a written request for payment accompanied by written
invoices and other written evidence reasonably satisfactory to Landlord showing
the costs incurred, until the earlier of the exhaustion of the Amortized Costs
or the last day of the sixth (6th) month of the Lease term.

     (h)  All work performed at the Industrial Center or in the Premises by
Tenant or Contractor shall be subject to the following additional requirements:

     (1)  Such work shall not proceed until Landlord has approved in writing: 
(i) the Contractor, (ii) the amount and coverage of public liability and
property damage insurance, with Landlord named as an additional insured, carried
by Contractor, (iii) complete and detailed plans and specifications for such
work, and (iv) a schedule for the work.

                                       -42-


<PAGE>


     (2)  All work shall be done in conformity with a valid permit when
required, a copy of which shall be furnished to Landlord before such work is
commenced.  In any case, all such work shall be performed in accordance with
all applicable laws.  Notwithstanding any failure by Landlord to object to any
such work, Landlord shall have no responsibility for Tenant's failure to comply
with applicable laws.

     (3)  Tenant or Contractor shall arrange for necessary utility, hoisting
and elevator service.

     (4)  Tenant's entry on the Premises for any purpose, including inspection
or performance of improvement work by Tenant, prior to the Commencement Date
shall be subject to all of the covenants of this Lease except the payment of
rent.  Entry by Tenant shall include entry by Tenant's officers, employees,
agents, contractors, licensees or invitees.

     (5)  Tenant shall be responsible for cleaning the Premises and removing
all debris.  All completed work shall be subject to inspection and acceptance by
Landlord.  Tenant shall reimburse Landlord upon demand for all extra expense
incurred by Landlord by reason of faulty work done by Tenant or Contractor by
reason of inadequate cleanup by Tenant or Contractor.

     53.  EQUIPMENT LEASING.  Tenant's Trade Fixtures are not required to remain
upon the Premises and be surrendered therewith upon termination of this Lease. 
Trade Fixtures now or hereafter installed and used by Tenant on the Premises may
or will be directly financed by a third-party lender or otherwise subjected to a
security interest or owned by an equipment rental company or vendor ("Equipment
Lessor") and leased to Tenant either directly from the Equipment Lessor or by
way of equipment sublease or assignment of equipment lease from an equipment
sublessor ("Equipment Sublessor"), and the Landlord hereby agrees to recognize
the rights therein of any such third-party lender, vendor, or Equipment Lessor
or Sublessor (or assignee).  Landlord agrees that all such items of financed or
leased Trade Fixtures installed or to be installed on the Premises shall be and
remain personal property and not real property, notwithstanding the fact that
the same may be nailed or screwed or otherwise attached or affixed to the
Premises, and further agrees to recognize the rights therein of any such
third-party lender, vendor, or Equipment Lessor or Sublessor (or assignee).
Tenant shall have the right at any time, provided Tenant is not

                                       -43-


<PAGE>



in default hereunder, to remove or replace any or all Trade Fixtures, whether
or not financed or leased, regardless of whether attached or affixed to the
Premises, and to the extent of their respective interests therein such
third-party lender, vendor, or Equipment Lessor or Sublessor (or assignee)
shall also have such a right regardless of whether Tenant is in default
hereunder.  Any damage to the Premises caused by such a removal shall be
repaired promptly by and at the expense of Tenant or other party causing such
removal.  Landlord agrees that it does not have and shall not assert any
right, lien or claim in or to the Trade Fixtures against any third-party
lender, vendor, or Equipment Lessor or Sublessor (or assignee), and, subject
to the obligation promptly to repair any damage to the Premises, such party
may remove and dispose of the same without reference to, and free and clear
of, any or other demand of Landlord; provided, however that no such disposal
or sale may be made on the Premises.  Landlord agrees to execute a waiver of
Landlord's lien upon the request of any Equipment Lessor or Sublessor
substantially in form and content as set forth on EXHIBIT C hereto.

     54.  MISCELLANEOUS.  This Lease cannot be changed orally, but only by
agreement in writing signed by the party against whom, or against whose
successors and assigns, enforcement of the change is sought.  The voluntary or
other surrender of this Lease by Tenant, or a mutual cancellation thereof, shall
not  work a merger as to any existing subtenancies and shall, at the
option of Landlord, terminate any and all such existing subtenancies or, at
Landlord's option, operate as an assignment to it of any and all such
subtenancies.  The words "Landlord" and "Tenant" as used herein shall include
the plural as well as the singular.  If there is more than one tenant, the
obligations hereunder imposed upon the tenant shall be joint and several.
Time is of the essence of this Lease and each and all of its provisions.
This Lease shall be construed and enforced in accordance with the
laws of the State in which the Premises are situated.  The term "Default
Interest Rate" shall mean an annual rate equal to two percent (2%) over the
annual prime rate of interest announced publicly by Citibank, N.A. in New York,
New York from time to time or the maximum interest rate permitted by law,
whichever is less.  Any amount due from Tenant, if not paid when first due,
shall bear interest at the Default Interest Rate from the date due until paid. 
If any covenant, agreement, or condition of this Lease or the application
thereof to any

                                       -44-


<PAGE>
person, firm, corporation, or circumstance is or becomes to any extent invalid
or unenforceable, the remainder of this Lease, or the application of such
covenant, agreement, or condition to persons, firms, corporations, or
circumstances other than those as to which it is invalid or unenforceable, shall
not be affected thereby, and in lieu of each clause or provision of this Lease
that is illegal, invalid, or unenforceable, there shall be added as a part of
this Lease a clause or provision as similar in terms to such clause or provision
as is possible and as may be legal, valid, and enforceable.  If any excavation
or other building operation shall be made, or about to be made, upon any
adjoining property or streets, upon the request of Landlord, Tenant shall permit
the owner or lessee of such adjoining property and their respective
representatives to enter the Premises and shore the foundations and walls
thereof, and to do any other act or thing reasonably necessary, in Landlord's
opinion, for the safety or preservation of the Building and Premises. 
Landlord's acceptance of a partial rent payment shall not constitute a waiver of
any rights of Tenant or Landlord, including, without limitation, any right
Landlord may have to recover possession of the Premises, in unlawful detainer,
or otherwise.  The parties agree that the covenants and agreements herein
contained shall bind and inure to the benefit of Landlord and its successors and
assigns, and shall bind and inure to the benefit of Tenant and its successors
and assigns, subject to the provisions of paragraph 32, and provided that any
consent required to any assignment hereof shall be had and obtained as specified
in this Lease.

                                       -45-


<PAGE>



    Exhibits A, B and C, consisting of seven (7) pages, are attached hereto and
become part of this Lease.

    IN WITNESS WHEREOF, Landlord and Tenant have executed this Lease as of the
day and year first above written.

                             LANDLORD:
                             
                             THE EQUITABLE LIFE ASSURANCE SOCIETY OF
                             THE UNITED STATES, a New York
                             corporation
                             
                             
                             
                             By   /s/ Michael A. Evans
                                ------------------------------------
                                Its Investment Officer   
                                   ---------------------------------
                             
                             TENANT:
                             
                             ARRIS PHARMACEUTICAL CORPORATION, a
                             Delaware corporation
                             
                             
                             
                             By   /s/ Daniel H. Petree
                                ------------------------------------
                                Its Exec. V.P.
                                   ---------------------------------



                                       -46-


<PAGE>




                                       EXHIBIT A

                    DESCRIPTION OF PREMISES AND INDUSTRIAL CENTER


<PAGE>


                                      EXHIBIT B

                                    PARKING PARCEL


<PAGE>


                                      EXHIBIT C
                                           
                           LANDLORD'S WAIVER AND AGREEMENT



    WHEREAS, ______________________________________________ (hereinafter
"Landlord") is the Landlord and _______________ ______________, (hereinafter
"Tenant") is the tenant pursuant to that certain leased dated
__________________________ (hereinafter "Lease") covering a all or a portion of
the real property commonly known as (hereinafter "Premises"); and

    WHEREAS, ____________ (hereinafter "Lender") has made, or will make, a
certain loan or will sell, subject to and be secured by a security interest in,
that certain personal property or equipment described in Exhibit A hereto
(hereinafter "Personal Property") which is now or about to be located on the
Premises.

    NOW, THEREFORE, so long as the Lease has not been terminated and the loan
secured by Lender's security interest in the Personal Property remains
outstanding, and in consideration of the mutual covenants and agreements herein
contained, Landlord, Tenant and Lender hereby covenant and agree as follows:

    (1)  Landlord waives any interest in the Personal Property and agrees
that the Personal Property shall not become part of the Premises regardless of
the manner in which the Personal Premises may be attached or affixed to the
Premises provided that the Premises is not materially damaged or altered
thereby.

    (2)  Landlord agrees it will not prevent Lender or its designee from 
entering upon the Premises at all reasonable times to inspect or remove the 
Personal Property, and Lender agrees to promptly and fully repair any 
resulting damage to the Premises.

    (3)  Lender and Tenant shall each indemnify and defend Landlord (with 
attorney's reasonably satisfactory to Landlord) and hold Landlord harmless 
from any and all loss, cost, expense, damage, claim, or liability arising in 
any manner whatsoever out of the exercise by Lender of any rights pursuant to 
this Waiver and Agreement, including, without limitation, any damage or 
injury to any person or property occurring in, on or about the

<PAGE>


Premises which was caused by the negligence or willful misconduct of Lender or
its agents, employees, or invitees.

    (4)  Upon written request and notification by Landlord of the
termination of the Lease or the exercise of its rights to possession of the
Premises by virtue thereof, Lender agrees to cause the Personal Property to be
removed from the Premises and any resulting damage to the Premises to be
promptly repaired. Within ten (10) days after such written request and notice to
Lender, if the Personal Property has not been removed, Landlord may remove the
Personal Property and repair any resulting damage to the Premises at Lender's
expense wholly without liability by Landlord to Lender for any damage to the
Personal Property or any impairment of Lender's security interest. 
Notwithstanding the foregoing, Lender may elect to assume Tenant's rights and
obligations under the Lease of the Premises, and Landlord hereby consents
thereto.

    (5)  All requests, notices or service provided for or permitted to
be-given or made pursuant to this Waiver and Agreement shall be deemed to be an
adequate and sufficient notice if given in writing and service is made by
registered or certified mail or overnight air courier, or by facsimile
communication, addressed to the addresses set forth below, or to such other
addresses as may from time to time be specified in writing by either party-to
the other:

    If to Landlord:

         --------------------------------
         --------------------------------
         --------------------------------
         --------------------------------

    and

         --------------------------------
         --------------------------------
         --------------------------------
         --------------------------------

    If to Lender:

         --------------------------------
         --------------------------------
<PAGE>

         --------------------------------
         --------------------------------



    (6)  Tenant consents to the terms and provisions of this Waiver and 
Agreement.

    (7)  Notwithstanding any provision of this Waiver and Agreement to the 
contrary, Landlord shall have the rights provided for pursuant to California 
Civil Code Sections 1980 through 1991 or any successor statute.

    (8)  This Waiver and Agreement is binding upon and inures to the
benefit of Landlord and Lender and their respective successors and assigns, and
to no other person or entities, and shall become effective on the date it is
fully executed and by both Landlord and Lender, and Landlord has been served
with a fully executed copy.

    (9)  In the event that either party to this Lease commences any action
or proceeding against the other by reason of any breach or alleged breach of any
term or condition of this Waiver and Agreement or for the interpretation of this
Waiver and Agreement, the prevailing party in such an action or proceeding shall
be entitled to recover such amount as the court may judge to be reasonable
attorney's fees, and all reasonable costs incurred.  The court shall determine
the prevailing party.
`
Lender:                      Landlord:


- -------------------------    -----------------------------

Date:  ------------------    Date:  ----------------------


Tenant:

- -------------------------

Date:  ------------------



<PAGE>

_______________________________________________________________________________
                                EXHIBIT 10.40
BANK OF AMERICA                                 BUSINESS LOAN AGREEMENT
NATIONAL TRUST AND SAVINGS ASSOCIATION
_______________________________________________________________________________

This Agreement dated as of September 24, 1996, is between Bank of America 
National Trust and Savings Association (the "Bank") and Arris Pharmaceutical 
Corporation (the "Borrower").

1.   LINE OF CREDIT AMOUNT AND TERMS

1.1  LINE OF CREDIT AMOUNT.

(a)  During the availability period described below, the Bank will provide a
     line of credit to the Borrower.  The amount of the line of credit (the
     "Commitment") is the lesser of:

     (i)  Twelve Million Dollars ($12,000,000) or

     (ii) the sum of the following:

          (A)  the amount of Bank of America time deposits pledged to the Bank;
               plus

          (B)  the loan value of the marketable securities pledged to the Bank.
               The loan value of a marketable security will be a percentage of 
               its fair market value.  Except for the types of securities listed
               below, the fair market value will be determined by the Bank from 
               time to time in its sole discretion.  The percentage applied to 
               a particular marketable security will be set by the Bank at the 
               time it is pledged to the Bank.  The percentage can be changed by
               the Bank at any time for reasonable cause.  The Bank's records of
               the applicable percentage will be controlling.  It is provided, 
               however, that notwithstanding any of the foregoing, the Bank and 
               the Borrower agree that the loan value of marketable securities 
               consisting of (1) U.S. treasury bills will be 90%, (2) U.S. 
               treasury notes or bonds or other obligations issued or guaranteed
               by the federal government and with maturities longer than one 
               year will be 80%, and (3) U.S. corporate or municipal bonds rated
               at least AA by Standard & Poor's Ratings Group or at least Aa by 
               Moody's Investors Service, Inc. will be 75%.
              
     If at any time the total amount of principal outstanding under the line of
     credit exceeds this limit, the Borrower will immediately either increase
     the loan value of marketable securities or other acceptable collateral
     pledged to the Bank, or reduce the total amount outstanding in order to
     comply with this limit.  If any of the pledged assets are margin stock, the
     Borrower will provide the Bank a Form U-1 Purpose Statement, and the Bank
     and the Borrower will comply with the restrictions imposed by Regulation U
     of the Federal Reserve, which may require a reduction in the loan value of
     the margin stock pledged to the Bank.

     The Bank is prohibited from accepting as collateral certain Ineligible
     Securities while they are being underwritten or privately placed by BA
     Securities, Inc.  The Bank shall comply with these restrictions.  BA 
     Securities, Inc. is a wholly-owned subsidiary of BankAmerica Corporation, 
     and is a registered broker-dealer which is permitted to underwrite and deal
     in certain Ineligible Securities.  "Ineligible Securities" means securities
     which may not be underwritten or dealt in by member banks of the Federal 
     Reserve System under Section 16 of the Banking Act of 1933 (12 U.S.C. 
     Section 24, Seventh), as amended.

(b)  This is a revolving line of credit with a term repayment option.  During
     the availability period, the Borrower may repay principal amounts and 
     reborrow them.


                                      -1-
<PAGE>

(c)  The Borrower agrees not to permit the outstanding principal balance of the
     line of credit to exceed the Commitment.

1.2  AVAILABILITY PERIOD.  The line of credit is available between the date of
this Agreement and December 31, 1997 (the "Expiration Date") unless the Borrower
is in default.

1.3  INTEREST RATE.

(a)  Unless the Borrower elects an optional interest rate as described below, 
     the interest rate is (i) the Bank's Reference Rate minus 1.50 percentage
     points with respect to that portion of the outstanding principal balance 
     of the line of credit that is less than or equal to the amount of Bank of 
     America time deposits pledged to the Bank and (ii) the Bank's Reference 
     Rate minus 1.0 percentage point with respect to that portion of the 
     outstanding principal balance of the line of credit that exceeds the amount
     of Bank of America time deposits pledged to the Bank.

(b)  The Reference Rate is the rate of interest publicly announced from time to
     time by the Bank in San Francisco, California, as its Reference Rate.  The
     Reference Rate is set by the Bank based on various factors, including the 
     Bank's costs and desired return, general economic conditions and other 
     factors, and is used as a reference point for pricing some loans.  The Bank
     may price loans to its customers at, above, or below the Reference Rate. 
     Any change in the Reference Rate shall take effect at the opening of 
     business on the day specified in the public announcement of a change in the
     Bank's Reference Rate.

1.4  REPAYMENT TERMS.

(a)  The Borrower will pay interest on October 1, 1996, and then monthly
     thereafter until payment in full of any principal outstanding under this 
     line of credit.

(b)  The Borrower will repay the principal amount outstanding on the Expiration
     Date in 20 successive equal quarterly installments starting April 1, 1998. 
     On December 31, 2002, the Borrower will repay the remaining principal 
     balance plus any interest then due.

(c)  The Borrower may prepay the loan in full or in part at any time.  The
     prepayment will be applied to the most remote installment of principal due
     under this Agreement.

1.5  OPTIONAL INTEREST RATES.  Instead of the interest rate based on the Bank's
Reference Rate, the Borrower may elect to have all or portions of the line of
credit (during the availability period and during the term repayment period)
bear interest at the rate(s) described below during an interest period agreed to
by the Bank and the Borrower.  Each interest rate is a rate per year.  Interest
will be paid on the last day of each interest period, and, if the interest
period is longer than three months, then on the last day each quarter during the
interest period.  At the end of any interest period, the interest rate will
revert to the rate based on the Reference Rate, unless the Borrower has
designated another optional interest rate for the portion.

1.6  LIBOR RATE.  The Borrower may elect to have all or portions of the
principal balance bear interest at the LIBOR Rate plus the applicable spread. 
The applicable spread will be (1) 0.495 percentage point with respect to that
portion of the outstanding LIBOR Rate portions that, when added to the
outstanding principal balance (if any) bearing interest at the Bank's Reference
Rate minus 1.5 percentage points, results in a sum less than or equal to the
amount of Bank of America time deposits pledged to the Bank and (2) 0.995
percentage point with respect to the remaining portion of the outstanding LIBOR
Rate portions.

Designation of a LIBOR Rate portion is subject to the following requirements:

(a)  The interest period during which the LIBOR Rate will be in effect will be
     one, two, three, or six months.  The first day of the interest period must
     be a day other than a Saturday or a Sunday on which the Bank is open for 
     business in California, New York and London and dealing in offshore dollars
     (a "LIBOR 


                                      -2-
<PAGE>

     Banking Day").  The last day of the interest period and the actual number 
     of days during the interest period will be determined by the Bank using the
     practices of the London inter-bank market.

(b)  Each LIBOR Rate portion will be for an amount not less than Five Hundred
     Thousand Dollars ($500,000).

(c)  The "LIBOR Rate" means the interest rate determined by the following
     formula, rounded upward to the nearest 1/100 of one percent.  (All amounts
     in the calculation will be determined by the Bank as of the first day of 
     the interest period.)

                   LIBOR Rate  =  London Inter-Bank Offered Rate
                                  ------------------------------
                                    (1.00 - Reserve Percentage)

     Where,

     (i)  "London Inter-Bank Offered Rate" means the interest rate (rounded
          upward to the nearest  1/16th of one percent) at which the Bank's 
          London Branch, London, Great Britain, would offer U.S. dollar deposits
          for the applicable interest period to other major banks in the London 
          inter-bank market at approximately 11:00 a.m. London time two (2) 
          London Banking Days before the commencement of the interest period.  
          A "London Banking Day" is a day on which the Bank's London Branch is 
          open for business and dealing in offshore dollars.

     (ii) "Reserve Percentage" means the total of the maximum reserve 
           percentages for determining the reserves to be maintained by member 
           banks of the Federal Reserve System for Eurocurrency Liabilities, as 
           defined in Federal Reserve Board Regulation D, rounded upward to the 
           nearest 1/100 of one percent.  The percentage will be expressed as a 
           decimal, and will include, but not be limited to, marginal, 
           emergency, supplemental, special, and other reserve percentages.

(d)  The Borrower shall irrevocably request a LIBOR Rate portion no later than
     12:00 noon San Francisco time on the LIBOR Banking Day preceding the day on
     which the London Inter-Bank Offered Rate will be set, as specified above.

(e)  The Borrower may not elect a LIBOR Rate with respect to any principal
     amount which is scheduled to be repaid before the last day of the 
     applicable interest period.

(f)  Any portion of the principal balance already bearing interest at the LIBOR
     Rate will not be converted to a  different rate during its interest period.

(g)  Each prepayment of a LIBOR Rate portion, whether voluntary, by reason of
     acceleration or otherwise, will be accompanied by the amount of accrued 
     interest on the amount prepaid and a prepayment fee as described below.  
     A "prepayment" is a payment of an amount on a date earlier than the 
     scheduled payment date for such amount as required by this Agreement.  
     The prepayment fee shall be equal to the amount (if any) by which:

     (i)  the additional interest which would have been payable during the
          interest period on the amount prepaid had it not been prepaid, exceeds

     (ii) the interest which would have been recoverable by the Bank by placing
          the amount prepaid on deposit in the domestic certificate of deposit
          market, the eurodollar deposit market, or other appropriate money 
          market selected by the Bank, for a period starting on the date on 
          which it was prepaid and ending on the last day of the interest period
          for such portion (or the scheduled payment date for the amount 
          prepaid, if earlier).


                                      -3-
<PAGE>

(h)  The Bank will have no obligation to accept an election for a LIBOR Rate
     portion if Dollar deposits in the principal amount, and for periods equal 
     to the interest period, of a LIBOR Rate portion are not available in the 
     London inter-bank market.

2.   EXPENSES

(a)  The Borrower agrees to immediately repay the Bank for expenses that 
     include, but not limited to, filing, recording and search fees, appraisal 
     fees and documentation fees related to this Agreement.

(b)  The Borrower agrees to reimburse the Bank for any expenses it incurs in the
     preparation of this Agreement and any agreement or instrument required by 
     this Agreement up to a maximum of Five Thousand Dollars ($5,000).  Expenses
     include, but are not limited to, reasonable attorneys' fees, including any 
     allocated costs of the Bank's in-house counsel.

3.   COLLATERAL

3.1  PERSONAL PROPERTY.  The Borrower's obligations to the Bank under this 
Agreement will be secured by personal property the Borrower now owns or will 
own in the future as listed below.  The collateral is further defined in 
security agreement(s) executed by the Borrower.  In addition, all personal 
property collateral securing this Agreement shall also secure all other 
present and future obligations of the Borrower to the Bank (excluding any 
consumer credit covered by the federal Truth in Lending law, unless the 
Borrower has otherwise agreed in writing).  All personal property collateral 
securing any other present or future obligations of the Borrower to the Bank 
shall also secure this Agreement.

(a)  Stock and other securities.

(b)  Bank of America time deposits.

4.   DISBURSEMENTS, PAYMENTS AND COSTS

4.1  REQUESTS FOR CREDIT.  Each request for an extension of credit will be made
in writing in a manner reasonably acceptable to the Bank, or by another means
acceptable to the Bank.

4.2  DISBURSEMENTS AND PAYMENTS.  Each disbursement by the Bank and each payment
by the Borrower will be:

(a)  made at the Bank's branch (or other location) selected by the Bank from
     time to time;

(b)  made for the account of the Bank's branch selected by the Bank from time to
     time;

(c)  made in immediately available funds consisting of U.S. dollars;

(d)  evidenced by records kept by the Bank.  In addition, the Bank may, at its
     discretion, require the Borrower to sign one or more promissory notes.

4.3  TELEPHONE AND TELEFAX AUTHORIZATION.

(a)  The Bank may honor telephone or telefax instructions for advances or
     repayments or for the designation of optional interest rates given by any 
     one of the individuals authorized to sign loan agreements on behalf of the 
     Borrower, or any other individual designated by any one of such authorized 
     signers.

(b)  Advances will be deposited in and repayments will be withdrawn from the
     Borrower's account number 14998-04747, or such other of the Borrower's 
     accounts with the Bank as designated in writing by the Borrower.


                                      -4-
<PAGE>

(c)  The Borrower indemnifies and excuses the Bank (including its officers,
     employees, and agents) from all liability, loss, and costs in connection 
     with any act resulting from telephone or telefax instructions it reasonably
     believes are made by any individual authorized by the Borrower to give such
     instructions.  This indemnity and excuse will survive this Agreement.

4.4  DIRECT DEBIT (PRE-BILLING).

(a)  The Borrower agrees that the Bank will debit the Borrower's deposit account
     number 14998-04747 (the "Designated Account") on the date each payment of
     principal and interest and any fees from the Borrower becomes due (the "Due
     Date").  If the Due Date is not a banking day, the Designated Account will 
     be debited on the next banking day.

(b)  Approximately 10 days prior to each Due Date, the Bank will mail to the
     Borrower a statement of the amounts that will be due on that Due Date (the
     "Billed Amount").  The calculation will be made on the assumption that no 
     new extensions of credit or payments will be made between the date of the 
     billing statement and the Due Date, and that there will be no changes in 
     the applicable interest rate.

(c)  The Bank will debit the Designated Account for the Billed Amount,
     regardless of the actual amount due on that date (the "Accrued Amount").

     If the Billed Amount debited to the Designated Account differs from the
     Accrued Amount, the discrepancy will be treated as follows:

     (i)  If the Billed Amount is less than the Accrued Amount, the Billed
          Amount for the following Due Date will be increased by the amount of 
          the discrepancy.  The Borrower will not be in default by reason of 
          any such discrepancy.
    
     (ii) If the Billed Amount is more than the Accrued Amount, the Billed
          Amount for the following Due Date will be decreased by the amount of 
          the discrepancy.

     Regardless of any such discrepancy, interest will continue to accrue based
     on the actual amount of principal outstanding without compounding.  The
     Bank will not pay the Borrower interest on any overpayment.

(d)  The Borrower will maintain sufficient funds in the Designated Account to
     cover each debit.  If there are insufficient funds in the Designated 
     Account on the date the Bank enters any debit authorized by this Agreement,
     the debit will be reversed.

4.5  BANKING DAYS.  Unless otherwise provided in this Agreement, a banking day
is a day other than a Saturday or a Sunday on which the Bank is open for
business in California. All payments and disbursements which would be due on a
day which is not a banking day will be due on the next banking day.  All
payments received on a day which is not a banking day will be applied to the
credit on the next banking day.

4.6  TAXES.  If any payments to the Bank under this Agreement are made from
outside the United States, the Borrower will not deduct any foreign taxes from
any payments it makes to the Bank.  If any such taxes are imposed on any
payments made by the Borrower (including payments under this paragraph), the
Borrower will pay the taxes and will also pay to the Bank, at the time interest
is paid, any additional amount which the Bank specifies as necessary to preserve
the after-tax yield the Bank would have received if such taxes had not been
imposed. The Borrower will confirm that it has paid the taxes by giving the Bank
official tax receipts (or notarized copies) within 30 days after the due date.

4.7 ADDITIONAL COSTS.


                                      -5-
<PAGE>

(a)  The Borrower will pay the Bank, on demand, for the Bank's costs or losses 
     arising from any statute or regulation, or any request or requirement of
     a regulatory agency which is applicable to all national banks or a class 
     of all national banks.  The costs and losses will be allocated to the loan 
     in a manner determined by the Bank, using any reasonable method.  The costs
     include the following:

     (i)  any reserve or deposit requirements; and

     (ii) any capital requirements relating to the Bank's assets and commitments
          for credit.

(b)  The Borrower's obligations under this subparagraph (a) of this paragraph 
     shall be limited to the Bank's costs and losses arising on or after the 
     date which is ninety (90) days after the date the Bank sends written notice
     to the Borrower confirming the Borrower's obligations under this paragraph 
     and describing in reasonably sufficient detail such costs and losses.

4.8  INTEREST CALCULATION.  Except as otherwise stated in this Agreement, all
interest and fees, if any, will be computed on the basis of a 360-day year and
the actual number of days elapsed.  This results in more interest or a higher
fee than if a 365-day year is used.

4.9  INTEREST ON LATE PAYMENTS.  At the Bank's sole option in each instance, any
amount not paid when due under this Agreement (including interest) shall bear
interest from the due date at the Bank's Reference Rate.  This may result in
compounding of interest.

4.10 DEFAULT RATE.  Upon the occurrence and during the continuation of any
default under this Agreement, advances under this Agreement will at the option
of the Bank bear interest at a rate per annum which is 1.0 percentage point
higher than the rate of interest otherwise provided under this Agreement.  This
will not constitute a waiver of any default.

5.   CONDITIONS

The Bank must receive the following items, in form and content acceptable to the
Bank, before it is required to extend any credit to the Borrower under this
Agreement:

5.1  AUTHORIZATIONS.  Evidence that the execution, delivery and performance by
the Borrower of this Agreement and any instrument or agreement required under
this Agreement have been duly authorized.

5.2  GOVERNING DOCUMENTS.  A copy of the Borrower's filed articles of
incorporation and any amendments thereto.

5.3  SECURITY AGREEMENTS.  Signed original security agreements, assignments and
financing statements (together with collateral in which the Bank requires a
possessory security interest), which the Bank requires.

5.4  EVIDENCE OF PRIORITY.  Evidence that security interests and liens in favor
of the Bank are valid, enforceable, and prior to all others' rights and
interests, except those the Bank consents to in writing.  This evidence must
include, without limitation, (i) a copy of a duly signed and filed financing
statement change (Form UCC-2) from Silicon Valley Bank ("SVB") with respect to
SVB's financing statement file no. 9519460184 pursuant to which SVB releases
from the collateral described in said financing statement any and all collateral
consisting of documents, cash, deposit accounts, securities accounts, investment
accounts, securities, certificates of deposit, instruments, chattel paper,
general intangibles and all other investments or property of any sort now or
hereafter owned by the Borrower AND maintained or administered by Bank of
America National Trust and Savings Association in the name of the Borrower or
for the benefit of the Borrower, and all proceeds thereof (the "BofA
Collateral") and (ii) a copy of duly signed and filed financing statement
changes (Form UCC-2) from Hambrecht & Quist Guaranty Finance, L. P. ("H&Q") with
respect to H&Q's financing statement file no. 94059807 and financing statement
file no. 9517760687 pursuant to which H&Q releases from the collateral described
in said financing statements any and all collateral consisting of the BofA
Collateral.


                                      -6-
<PAGE>

5.5  OTHER ITEMS.  Any other items that the Bank reasonably requires.

6.   REPRESENTATIONS AND WARRANTIES

When the Borrower signs this Agreement, and until the Bank is repaid in full,
the Borrower makes the following representations and warranties.  Each request
for an extension of credit constitutes a renewed representation.

6.1  ORGANIZATION OF BORROWER.  The Borrower is a corporation duly formed and
existing under the laws of the state where organized.

6.2  AUTHORIZATION.  This Agreement, and any instrument or agreement required
hereunder, are within the Borrower's powers, have been duly authorized, and do
not conflict with any of its organizational papers.

6.3  ENFORCEABLE AGREEMENT.  This Agreement is a legal, valid and binding
agreement of the Borrower, enforceable against the Borrower in accordance with
its terms, and any instrument or agreement required hereunder, when executed and
delivered, will be similarly legal, valid, binding and enforceable.

6.4  GOOD STANDING.  In each state in which the Borrower does business, it is
properly licensed, in good standing, and, where required, in compliance with
fictitious name statutes.

6.5  NO CONFLICTS.  This Agreement does not conflict with any law, agreement, or
obligation by which the Borrower is bound.

6.6  FINANCIAL INFORMATION.  All financial and other information that has been
or will be supplied to the Bank is:

(a)  sufficiently complete to give the Bank accurate knowledge of the Borrower's
     financial condition.

(b)  in form and content required by the Bank.

(c)  in compliance with all government regulations that apply.

6.7  LAWSUITS.  There is no lawsuit, tax claim or other dispute pending or
threatened against the Borrower, which, if lost, would impair the Borrower's
financial condition or ability to repay the loan, except as have been disclosed
in writing to the Bank.

6.8  PERMITS, FRANCHISES.  The Borrower possesses all permits, memberships,
franchises, contracts and licenses required and all trademark rights, trade name
rights, patent rights and fictitious name rights necessary to enable it to
conduct the business in which it is now engaged.

6.9  COLLATERAL.  All collateral required in this Agreement is owned by the
grantor of the security interest free of any title defects or any liens or
interests of others.

6.10 OTHER OBLIGATIONS.  The Borrower is not in default on any obligation for
borrowed money, any purchase money obligation or any other material lease,
commitment, contract, instrument or obligation.

6.11 INCOME TAX RETURNS.  The Borrower has no knowledge of any pending
assessments or adjustments of its income tax for any year.

6.12 NO EVENT OF DEFAULT.  There is no event which is, or with notice or lapse
of time or both would be, a default under this Agreement.

6.13 LOCATION OF BORROWER.  The Borrower's place of business (or, if the
Borrower has more than one place of business, its chief executive office) is
located at the address listed under the Borrower's signature on this Agreement.


                                      -7-
<PAGE>

7.   COVENANTS

The Borrower agrees, so long as credit is available under this Agreement and
until the Bank is repaid in full:

7.1  USE OF PROCEEDS.  To use the proceeds of the credit only for working
capital, capital expenditures and general corporate purposes.

7.2  USE OF PROCEEDS - INELIGIBLE SECURITIES.  Not to use, directly or
indirectly, any portion of the proceeds of the credit (including any letters of
credit) for any of the following purposes:

(a)  knowingly to purchase Ineligible Securities from BA Securities, Inc. (the
     "Arranger") during any period in which the Arranger makes a market in such
     Ineligible Securities; or 

(b)  knowingly to purchase during the underwriting or placement period 
     Ineligible Securities being underwritten or privately placed by the 
     Arranger.

7.3  FINANCIAL INFORMATION.  To provide the following financial information and
statements and such additional information as requested by the Bank from time to
time:

(a)  Within 120 days of the Borrower's fiscal year end, the Borrower's annual
     financial statements.  These financial statements must be audited (with an
     unqualified opinion) by Ernst & Young or by another Certified Public 
     Accountant ("CPA") acceptable to the Bank.

(b)  Copies of the Borrower's Form 10-K Annual Report, within 120 days of the
     Borrower's fiscal year end.

(c)  Copies of the Borrower's Form 10-Q Quarterly Report, within 60 days of the
     period's end.

(d)  Copies of the Borrower's Form 8-K Current Report within 30 days after the
     date of filing with the Securities and Exchange Commission.

7.4  NOTICES TO BANK.  To promptly notify the Bank in writing of:

(a)  any lawsuit over One Million Dollars ($1,000,000) against the Borrower.

(b)  any substantial dispute between the Borrower and any government authority.

(c)  any failure to comply with this Agreement.

(d)  any material adverse change in the Borrower's financial condition or
     ability to repay the loan (any such change hereinafter referred to as a
     "Material Adverse Change).

(e)  any change in the Borrower's name, legal structure, place of business, or
     chief executive office if the Borrower has more than one place of business.

7.5  BOOKS AND RECORDS.  To maintain adequate books and records.

7.6  COMPLIANCE WITH LAWS.  To comply with the laws (including any fictitious
name statute), regulations, and orders of any government body with authority
over the Borrower's business with which the failure to comply would cause a
Material Adverse Change.

7.7  PRESERVATION OF RIGHTS.  To maintain and preserve all rights, privileges,
and franchises which the Borrower now has and which the failure to maintain or
preserve would cause a Material Adverse Change.


                                      -8-
<PAGE>

7.8  PERFECTION OF LIENS.  To help the Bank perfect and protect its security
interests and liens, and reimburse it for related necessary costs it incurs to
protect its security interests and liens.

7.9  INSURANCE.  To maintain insurance as is usual for the business it is in.

7.10 ADDITIONAL NEGATIVE COVENANTS.  Not to, without the Bank's written consent
(which consent shall not be unreasonably withheld):

(a)  engage in any business activities material in scope and substantially
     different from the Borrower's present business, which is health care.

(b)  liquidate or dissolve the Borrower's business.

8.   DEFAULT

If any of the following events occur, the Bank may do one or more of the
following: declare the Borrower in default, stop making any additional credit
available to the Borrower, and require the Borrower to repay its entire debt
immediately and without prior notice.  If an event of default occurs under the
paragraph entitled "Bankruptcy," below, then the entire debt outstanding under
this Agreement will automatically be due immediately or, with respect to any
bankruptcy petition filed against the Borrower, immediately upon the expiration
of the cure period without dismissal of the petition.

8.1  FAILURE TO PAY.  The Borrower fails to make a payment under this Agreement
within 15 days after the date when due.

8.2  LIEN PRIORITY.  The Bank fails to have an enforceable first lien (except
for any prior liens to which the Bank has consented in writing) on or security
interest in any property given as security for this loan.

8.3  FALSE INFORMATION.  The Borrower has given the Bank false or misleading
information or representations.

8.4  BANKRUPTCY.  The Borrower files a bankruptcy petition, a bankruptcy
petition is filed against the Borrower, or the Borrower makes a general
assignment for the benefit of creditors. The default will be deemed cured if any
bankruptcy petition filed against the Borrower is dismissed within a period of
45 days after the filing; provided, however, that the Bank will not be obligated
to extend any additional credit to the Borrower during that period.

8.5  RECEIVERS.  A receiver or similar official is appointed for the Borrower's
business, or the business is terminated.

8.6  LAWSUITS.  Any lawsuit or lawsuits are filed on behalf of one or more trade
creditors against the Borrower in an aggregate amount of Five Million Dollars
($5,000,000) or more in excess of any insurance coverage, and such lawsuit or
lawsuits are not dismissed within 30 days after filing; provided, however, that
the Bank will not be obligated to extend any additional credit to the Borrower
during that period.

8.7  JUDGMENTS.  Any judgments or arbitration awards are entered against the
Borrower, or the Borrower enters into any settlement agreements with respect to
any litigation or arbitration, in an aggregate amount of Five Million Dollars
($5,000,000) or more in excess of any insurance coverage, and such judgments or
arbitration awards remain unstayed, unvacated, undischarged or unsatisfied for
45 days after entry; provided, however, that the Bank will not be obligated to
extend any additional credit to the Borrower during that period.

8.8  GOVERNMENT ACTION.  Any government authority takes final, non-appealable
action that results in a Material Adverse Change.

8.9  MATERIAL ADVERSE CHANGE.  A Material Adverse Change occurs.


                                      -9-
<PAGE>

8.10 DEFAULT UNDER RELATED DOCUMENTS.  Any guaranty, subordination agreement,
security agreement, deed of trust, or other document required by this Agreement
is no longer in effect,  or any such document is violated, and, if there is an
applicable grace or cure period, the violation continues beyond such grace or
cure period.

8.11 OTHER BANK AGREEMENTS.  The Borrower fails to meet the material conditions
of, or fails to perform any material obligation under any other agreement the
Borrower has with the Bank or any affiliate of the Bank.  If, in the Bank's
opinion, the breach is capable of being remedied, the breach will not be
considered an event of default under this Agreement for a period of 30 days
after the date on which the Bank gives written notice of the breach to the
Borrower; provided, however, that the Bank will not be obligated to extend any
additional credit to the Borrower during that period.

8.12 OTHER BREACH UNDER AGREEMENT.  The Borrower fails to meet the conditions
of, or fails to perform any obligation under, any term of this Agreement not
specifically referred to in this Article.  If, in the Bank's opinion, the breach
is capable of being remedied, the breach will not be considered an event of
default under this Agreement for a period of 30 days after the date on which the
Bank gives written notice of the breach to the Borrower; provided, however, that
the Bank will not be obligated to extend any additional credit to the Borrower
during that period.

9.   ENFORCING THIS AGREEMENT; MISCELLANEOUS

9.1  GAAP.  Except as otherwise stated in this Agreement, all financial
information provided to the Bank and all financial covenants will be made under
generally accepted accounting principles, consistently applied.

9.2  CALIFORNIA LAW.  This Agreement is governed by California law.

9.3  SUCCESSORS AND ASSIGNS.  This Agreement is binding on the Borrower's and
the Bank's successors and assignees.  The Borrower agrees that it may not assign
this Agreement without the Bank's prior consent.  The Bank may sell
participations in or, with the prior consent of the Borrower, (which consent
shall not be unreasonably withheld) assign this loan, and may exchange financial
information about the Borrower with actual or potential participants or
assignees.  If a participation is sold or the loan is assigned, the purchaser
will have the right of set-off against the Borrower.

9.4  ARBITRATION.

(a)  This paragraph concerns the resolution of any controversies or claims
     between the Borrower and the Bank, including but not limited to those that 
     arise from:
    
     (i)  This Agreement (including any renewals, extensions or modifications of
          this Agreement);

     (ii) Any document, agreement or procedure related to or delivered in
          connection with this Agreement;

     (iii)Any violation of this Agreement; or

     (iv) Any claims for damages resulting from any business conducted between
          the Borrower and the Bank, including claims for injury to persons, 
          property or business interests (torts).

(b)  At the request of the Borrower or the Bank, any such controversies or
     claims will be settled by arbitration in accordance with the United States 
     Arbitration Act.  The United States Arbitration Act will apply even though 
     this Agreement provides that it is governed by California law.

(c)  Arbitration proceedings will be administered by the American Arbitration
     Association and will be subject to its commercial rules of arbitration.


                                      -10-
<PAGE>

(d)  For purposes of the application of the statute of limitations, the filing
     of an arbitration pursuant to this paragraph is the equivalent of the 
     filing of a lawsuit, and any claim or controversy which may be arbitrated 
     under this paragraph is subject to any applicable statute of limitations. 
     The arbitrators will have the authority to decide whether any such claim or
     controversy is barred by the statute of limitations and, if so, to dismiss 
     the arbitration on that basis.

(e)  If there is a dispute as to whether an issue is arbitrable, the arbitrators
     will have the authority to resolve any such dispute.

(f)  The decision that results from an arbitration proceeding may be submitted
     to any authorized court of law to be confirmed and enforced.

(g)  The procedure described above will not apply if the controversy or claim,
     at the time of the proposed submission to arbitration, arises from or 
     relates to an obligation to the Bank secured by real property located in 
     California.  In this case, both the Borrower and the Bank must consent to 
     submission of the claim or controversy to arbitration.  If both parties do
     not consent to arbitration, the controversy or claim will be settled as 
     follows:
    
     (i)  The Borrower and the Bank will designate a referee (or a panel of
          referees) selected under the auspices of the American Arbitration
          Association in the same manner as arbitrators are selected in 
          Association-sponsored proceedings;
    
     (ii) The designated referee (or the panel of referees) will be appointed by
          a court as provided in California Code of Civil Procedure Section 638 
          and the following related sections;

     (iii)The referee (or the presiding referee of the panel) will be an
          active attorney or a retired judge; and
    
     (iv) The award that results from the decision of the referee (or the panel)
          will be entered as a judgment in the court that appointed the referee,
          in accordance with the provisions of California Code of Civil 
          Procedure Sections 644 and 645.

(h)  This provision does not limit the right of the Borrower or the Bank to:

     (i)  exercise self-help remedies such as setoff;

     (ii) foreclose against or sell any real or personal property collateral; or

     (iii)act in a court of law, before, during or after the arbitration
          proceeding to obtain:
         
          (A)  an interim remedy; and/or

          (B)  additional or supplementary remedies.
    
(i)  The pursuit of or a successful action for interim, additional or
     supplementary remedies, or the filing of a court action, does not 
     constitute a waiver of the right of the Borrower or the Bank, including the
     suing party, to submit the controversy or claim to arbitration if the other
     party contests the lawsuit.  However, if the controversy or claim arises 
     from or relates to an obligation to the Bank which is secured by real 
     property located in California at the time of the proposed submission to 
     arbitration, this right is limited according to the provision above 
     requiring the consent of both the Borrower and the Bank to seek resolution 
     through arbitration.

(j)  If the Bank forecloses against any real property securing this Agreement,
     the Bank has the option to exercise the power of sale under the deed of 
     trust or mortgage, or to proceed by judicial foreclosure.


                                      -11-
<PAGE>

9.5  SEVERABILITY; WAIVERS.  If any part of this Agreement is not enforceable,
the rest of the Agreement may be enforced.  The Bank retains all rights, even if
it makes a loan after default.  If the Bank waives a default, it may enforce a
later default.  Any consent or waiver under this Agreement must be in writing.

9.6  ADMINISTRATION COSTS.  The Borrower shall pay the Bank for all reasonable
costs incurred by the Bank in connection with administering this Agreement.

9.7  ATTORNEYS' FEES.  The Borrower shall reimburse the Bank for any reasonable
attorneys' fees and costs incurred by the Bank in connection with the
enforcement or preservation of any rights or remedies under this Agreement and
any other documents executed in connection with this Agreement, and including
any amendment, waiver, "workout" or restructuring under this Agreement.  In the
event of a lawsuit or arbitration proceeding, the prevailing party is entitled
to recover costs and reasonable attorneys' fees incurred in connection with the
lawsuit or arbitration proceeding, as determined by the court or arbitrator.  In
the event that any case is commenced by or against the Borrower under the
Bankruptcy Code (Title 11, United States Code) or any similar or successor
statute, the Bank is entitled to recover costs and reasonable attorneys' fees
incurred by the Bank related to the preservation, protection, or enforcement of
any rights of the Bank in such a case.  As used in this paragraph, "attorneys'
fees" includes the allocated costs of in-house counsel.

9.8  ONE AGREEMENT.  This Agreement and any related security or other agreements
required by this Agreement, collectively:

(a)  represent the sum of the understandings and agreements between the Bank and
     the Borrower concerning this credit; and

(b)  replace any prior oral or written agreements between the Bank and the
     Borrower concerning this credit; and

(c)  are intended by the Bank and the Borrower as the final, complete and
     exclusive statement of the terms agreed to by them.

In the event of any conflict between this Agreement and any other agreements
required by this Agreement, this Agreement will prevail.

9.9  NOTICES.  All notices required under this Agreement shall be personally
delivered or sent by first class mail, postage prepaid, to the addresses on the
signature page of this Agreement, or to such other addresses as the Bank and the
Borrower may specify from time to time in writing.

9.10 HEADINGS.  Article and paragraph headings are for reference only and shall
not affect the interpretation or meaning of any provisions of this Agreement.

This Agreement is executed as of the date stated at the top of the first page.


BANK OF AMERICA
NATIONAL TRUST AND SAVINGS ASSOCIATION     ARRIS PHARMACEUTICAL CORPORATION



X /s/ Stephanie Barrell                    X /s/ Daniel H. Petree
  ------------------------------------       -------------------------------
BY:     STEPHANIE BARRELL                  BY:     DANIEL H. PETREE    
TITLE:  VICE PRESIDENT                     TITLE:  EVP CORPORATE DEVELOPMENT 
                                                   AND CHIEF FINANCIAL OFFICER


                                     -12-

<PAGE>

ADDRESS WHERE NOTICES TO THE BANK         ADDRESS WHERE NOTICES TO THE BORROWER
ARE TO BE SENT:                           ARE TO BE SENT:

San Francisco Commercial Banking          385 Olyster Point Blvd.
Office #1499                              South San Francisco, CA 94080 
345 Montgomery Street                  
San Francisco, CA 94104









                                      -13-


<PAGE>

                                    EXHIBIT 10.41
                                  SUBLEASE AGREEMENT



This Sublease Agreement ("Sublease") dated AUGUST 6, 1996 for reference purposes
only, is entered into by and between ARRIS PHARMACEUTICAL CORPORATION, a
Delaware corporation (hereinafter "Sublessor") and FIBROGEN, INC., a Delaware
corporation (hereinafter "Sublessee"), and is subject to the terms and
conditions of that certain Lease ("Master Lease") dated June 22, 1993 (as
amended by that certain First Amendment to Lease dated October 25, 1993) entered
into by UTAH PARTNERS, LTD., a California limited partnership, as Lessor, and
KHEPRI PHARMACEUTICALS, INC., a Delaware corporation, as Lessee.  A copy of the
Master Lease is attached hereto as Exhibit "A".  Sublessor is the successor by
merger of KHEPRI PHARMACEUTICALS, INC.

1.   PREMISES.  Sublessor hereby leases to Sublessee, and Sublessee hereby hires
from Sublessor, on and subject to the terms and conditions hereinafter set
forth, the following premises (hereinafter referred to as "Premises"), situated
in the City of South San Francisco, County of San Mateo, State of California,
commonly known as 260 LITTLEFIELD AVENUE, SUITE A and described as consisting of
approximately 32,700 rentable square feet as more particularly described in the
Master Lease TOGETHER WITH the equipment listed on Exhibit "A" hereto which is
now present in or about the Premises.  Sublessee shall have the right to use the
Common Areas of the property (as defined in the Master Lease).  For purposes of
this Lease the  Office/Unimproved Space consists of approximately 23,700 square
feet and the Laboratory Space consists of approximately 9,000 square feet.

2.   SUBLEASE TERM; DELIVERY OF POSSESSION.

     a.   TERM.  The term of this Sublease shall begin on October 15, 1996
("Commencement Date") and end on July 15, 2005 ("Expiration Date") unless sooner
terminated pursuant to any provision hereof or of the Master Lease.

     b.   DELIVERY OF POSSESSION.  

<PAGE>

        (1)   Notwithstanding said Commencement Date, if for any reason
Sublessor cannot deliver possession of the Premises to Sublessee on said date,
Sublessor shall not be subject to any liability therefore, nor shall such
failure affect the validity of this Sublease or the obligations of Sublessee
hereunder or extend the term hereof, but in such case Sublessee shall not be
obligated to pay rent until possession of the Premises is tendered to Sublessee;
provided, however, that if Sublessor shall not have delivered possession of the
Premises within ninety (90) days from said Commencement Date, Sublessee may, at
Sublessee's option, by notice in writing to Sublessor within ten (10) days
thereafter, cancel this Sublease, in which event the parties shall be discharged
from all obligations thereunder.  

        (2)   The Premises will be delivered by Sublessor subject to all
applicable zoning, municipal, county and state laws, ordinances and regulations
governing and regulating the use of the sublease Premises, and Sublessee accepts
the Premises subject thereto. Except as set forth in the next sentence,
Sublessee shall accept the Premises in broom clean condition and otherwise "as
is".  Landlord will cause the following work to be completed prior to the
Commencement Date:  paint touched up as needed; carpets cleaned; building
systems in working condition.

        (3)   Sublessor and Sublessee shall conduct a walk-through inspection
of the Premises prior to the Commencement Date, and if the building systems in
the Premises are found not to be in working condition, a "punchlist" shall be
developed identifying those areas of repairs which are necessary to bring such
building systems into working condition.  If such repairs are the obligation of
Sublessor as tenant under the Master Lease, Sublessor shall cause such repairs
to be made.  If such repairs are the obligation of the Master Lessor as landlord
under the Master Lease, Sublessor shall use reasonable efforts to cause Master
Lessor to perform such obligations as provided in paragraph 10 below.

     c.  EARLY POSSESSION.  In the event Sublessee, with Sublessor's consent,
takes possession prior to the Commencement Date, such occupancy shall be subject
to all the provisions of this Sublease, shall not advance the termination date
of this 

                                       2

<PAGE>

Sublease, and Sublessee shall pay rent for the period ending with the
Commencement Date at the same rental as prescribed for the initial month of the
Sublease term, prorated at the rate of 1/30th thereof per day.  If Sublessor
consents to entry for the purpose of installing furniture, equipment, telephone
and computer systems, and the like and/or for temporary staging or storage of
Sublessee's property, such entry shall NOT trigger an obligation to pay rental
prior to the Commencement Date. 

3.   OPTION TO EXTEND MASTER LEASE TERM.    Sublessor shall only be obligated to
exercise Sublessor's first extension option pursuant to the Master Lease if
Sublessee has not been in default under this Sublease more than two (2) times in
any lease year as of the latest date for Sublessor to exercise its extension
option provided for in the Master Lease. Sublessor shall have the right to
terminate this Sublease effective on July 15, 2000 if Sublessee has been in
default under this Sublease more than two (2) times in any lease year (a lease
year being the 12 month period commencing on the Commencement Date and ending on
the day prior to each anniversary of the Commencement Date) as of the latest
date for Sublessor to exercise its extension option provided for in the Master
Lease.

4.   RENT.  Sublessee shall pay to Sublessor without deduction, set off, prior
notice or demand, as rent for the Sublease Premises, monthly rent ("Base Rent")
as set forth in the rent schedule below. Sublessee shall pay Sublessor upon the
execution hereof the sum of Fifty Five Thousand Six Hundred Seventy Seven
Dollars ($55,677.00) as rent for the month of October 15, 1996 - November 14,
1996, assuming this Sublease Agreement commences on October 15, 1996.

                       RENT SCHEDULE - OFFICE/UNIMPROVED SPACE
                       ---------------------------------------

    TIME PERIOD                        BASE RENT PER MONTH
    -----------                        -------------------
    Months 1-24                        $1.21 per sq. ft./mo.
    Months 25-46                       $1.27 per sq. ft./mo.
    Months 47-106                      $1.35 per sq. ft./mo.


                                       3

<PAGE>

                           RENT SCHEDULE - LABORATORY SPACE
                           --------------------------------

    TIME PERIOD                        BASE RENT PER MONTH
    -----------                        -------------------
    Months 1-24                        $3.00 per sq. ft./mo.
    Months 25-46                       $3.00 per sq. ft./mo.
    Months 47-106                      $2.25 per sq. ft./mo.

5.   SECURITY DEPOSIT.  Sublessee shall deposit with Sublessor upon execution
hereof the sum of Fifty Five Thousand Six Hundred Seventy Seven Dollars
($55,677.00) as security for Sublessee's faithful performance of Sublessee's
obligations hereunder.  If Sublessee defaults with respect to any provision of
this Sublease, Sublessor may use, apply or retain all or any part of the
Security Deposit for the payment of any Rent or other sum in default, for the
payment of any amount which Sublessor may expend or become obligated to expend
by reason of Sublessee's default, or to compensate Sublessor for any loss or
damage which Sublessor may suffer by reason of Sublessee's default.  If any
portion of the Security Deposit is used or applied, Sublessee shall deposit with
Landlord, within ten (10) days after written demand therefor, cash in an amount
sufficient to restore the Security Deposit to its original amount.  Landlord
shall not be required to keep the Security Deposit separate from its general
funds.  If Sublessee performs all of its obligations hereunder, said deposit
shall be returned, without interest, to Sublessee within thirty (30) days after
expiration of term hereof.

6.   USE.

     a.   PERMITTED USE.  The Premises shall be used and occupied only for
laboratory, research and development, wet chemistry, biological laboratories,
related offices and uses which are ancillary thereto (including warehouse and
distribution of cosmetic products) and for no other purpose without the prior
written consent of Sublessor and Master Lessor.

     b.   NO REPRESENTATIONS OR WARRANTIES.  Sublessee acknowledges that neither
Sublessor nor Sublessor's agents have made any representation or warranty as to
the suitability of the Sublease Premises for the conduct of Sublessee's
business. 

                                       4

<PAGE>

7.   MASTER LEASE.

     a.  SUBLEASE IS SUBORDINATE TO MASTER LEASE.  This sublease is subject and
subordinate to the Master Lease.  Sublessee shall not commit or permit to be
committed on the Sublease Premises any act or omission which shall violate any
term or condition of the Master Lease.  If the Master Lease terminates, this
Sublease shall terminate.  Sublessor shall have no liability to Sublessee, if
the Master Lease terminates without fault of Sublessor.

     b.  APPLICATION OF MASTER LEASE PROVISIONS.  Except as otherwise expressly
provided in this Sublease, Sublessee shall assume and perform the obligations of
the Sublessor as Lessee under the Master Lease. Therefore, except as otherwise
provided, for the purpose of this Sublease, wherever in the Master Lease
"Landlord" is used, it shall be deemed to mean the Sublessor herein, and
wherever in the Master Lease "Tenant" is used, it shall be deemed to mean the
Sublessee herein, and wherever in the Master Lease "Lease" is used, it shall be
deemed to mean this Sublease.

     c.    INCORPORATION OF MASTER LEASE PROVISIONS.  

       (1) All of the terms and conditions in the Master Lease are incorporated
herein EXCEPT for:  Basic Lease Provisions; 1 (Premises); 3 (Term); 5 (Base
Rent); 8 (Tenant Improvements); 9.a. and 9.e. (Use of Premises); 10.c.
(Ownership of Alterations); 11.b. (Landlord's Ongoing Obligations); 11.c.
(Landlord's Delivery Obligations); 12 (Damage or Destruction); 13 (Eminent
Domain); 14.c. (Casualty Insurance); 15.e. (Payment on Sublet); 18 (Security
Deposit); 19 (Acceptance of Premises); 20 (Holding Over); 36 (Notices); 39.h.
(Entire Agreement); and Schedule A.  

       (2)  Except as otherwise provided herein, Sublessor is responsible for
all financial obligations under the Master Lease.  Whenever any provision of the
Master Lease has NOT been incorporated herein, except as otherwise provided, any
provision of the Addendum which pertains to a provision of the Master Lease
which has not been incorporated herein, shall NOT be incorporated herein.  In
addition, Master Lease Addendum paragraph 25 (stated 

                                       5

<PAGE>

to pertain to paragraph 14.b, but really pertaining to paragraph 14.c.),  Master
Lease Addendum paragraph 42 (pertaining to Master Lease paragraph 34) and Master
Lease Addendum paragraph 46 (pertaining to options to extend) shall not be 
incorporated into this Sublease.

     d.    INDEMNITY.  Sublessee shall hold Sublessor harmless of and from all
liability, judgments, costs, damages, claims or demands, including reasonable
attorney's fees, arising out of Sublessee's failure to comply with or perform
Sublessee's obligations under this Sublease.

    
     f.      MASTER LEASE IN EFFECT. Sublessor represents to Sublessee that the
Master Lease is in full force and effect and that, to Sublessor's knowledge, no
default exists on the part of any party to the Master Lease.  Subject to the
terms and provisions of this Sublease, Sublessor agrees to keep the Master Lease
in full force and effect during the term of this Sublease, subject, however, to
any earlier termination of the Master Lease without the default of Sublessor.

8.       OPERATING EXPENSES.  Sublessee shall pay as additional rent the
amounts for which Sublessor is liable to Master Lessor pursuant to paragraph 6
(Operating Expenses) of the Master Lease.  When incorporated into this Sublease,
references to "Landlord" in paragraphs 6.b. and 6.c. of the Master Lease  shall
be deemed to include Master Lessor and/or Sublessor. With respect to paragraph
6.e. as incorporated into this Sublease, Sublessor shall have 15 days following
receipt of Master Lessor's annual reconciliation within which to provide
Sublessor's reconciliation to Sublessee. As between Sublessor and Sublessee,
Sublessee shall only be liable for those Operating Expenses due by Sublessor to
Master Lessor under the Master Lease for calendar year 1996 in the same
proportion as the number of days remaining in calendar year 1996 from and after
the Commencement Date bears to 365 days.

9.       ALTERATIONS.    Notwithstanding the provisions of paragraph 10.a. of
the Master Lease, any alteration which requires Master Lessor's approval
pursuant to the Master Lease shall not be commenced by Sublessee unless and
until such consent is obtained.  

                                       6

<PAGE>

Any alteration made by Sublessee shall become a part of the Sublease Premises,
and at Sublessor's election, shall be surrendered to Sublessor at the end of 
the Sublease term. Any alteration made by Sublessee shall, at Sublessor's 
election become Sublessor's property throughout the Sublease term.  In the 
event Sublessor is (or becomes) obligated under the Master Lease to remove any 
of Sublessee's alterations, Sublessee shall be obligated to remove same at 
Sublessee's sole cost and expense and to restore the Premises to its condition 
prior to the alteration.

10.      REPAIRS.  Pursuant to paragraph 11.b. of the Master Lease Master
Lessor is responsible to repair and maintain the roof, exterior walls,
foundation and HVAC system (including distribution ducts) (provided that the
cost of maintaining, repairing and replacing the HVAC system shall be included
in Operating Expenses, pursuant to the terms of Section 6 of the Master Lease),
unexposed portions of the building plumbing and electrical systems (except to
the extent installed or modified by Sublessor or Sublessee), the Common Areas,
and structural portions of the Building. Master Lessor also has the obligation
to repair certain categories of items as provided in paragraph 17 of the
Addendum to the Master Lease. Sublessor's sole obligation to Sublessee shall be
to request performance of such obligations by Master Lessor.  In the event
Master Lessor breaches its obligations, Sublessor will assign to Sublessee its
right to enforce such obligation and shall otherwise cooperate with Sublessee in
connection therewith, provided, however, Sublessee, at its sole cost and
expense, shall be responsible for enforcement thereof without reimbursement from
Sublessor.  Sublessee, not Master Lessor, shall be responsible for the repair of
the roof and structural portions of the Building to the extent the need for
maintenance or repair is caused in whole or in part by the act, neglect, fault
or omission of any duty of Sublessee, its agents, servants, contractors,
subcontractors, employees or invitees, in which case Sublessee shall pay to
Sublessor the cost of the maintenance and repairs caused in whole or in part by
Sublessee (except (i) to the extent the damage is covered by any insurance
maintained by Master Lessor, or, (ii) if Master Lessor fails to maintain the
insurance required to be maintained by Master Lessor pursuant to the terms of
the Master Lease, to the extent the damage would have been covered by insurance,
if Master Lessor had maintained the required 

                                       7

<PAGE>

insurance).  There shall be no abatement of Rent and no liability of Master 
Lessor or Sublessor by reason of any injury to or interference with Sublessee's 
business arising from the making of any repairs, alterations or improvements in 
or to the fixtures, appurtenances and equipment therein, provided that Sublessor
shall request Master Lessor to use reasonable efforts to minimize the 
interruption of Sublessee's use and occupancy of the Premises in connection with
its performance of the repairs and maintenance (although nothing contained 
herein shall be deemed to obligate Master Lessor to pay any overtime costs in 
order to minimize such interference, or otherwise to perform the repairs or 
maintenance during hours other than normal business hours).

11.      INSURANCE.  

    a.        Sublessee shall, at its sole cost and expense, obtain and
maintain in force a policy or policies of fire and property damage insurance
providing protection against those perils included within the classification of
"all risk" insurance from an insurance company or companies reasonably
satisfactory to Sublessor and Master Lessor and in a form reasonably
satisfactory to Sublessor and Master Lessor insuring the Tenant Improvements (as
defined in the Master Lease) and all other improvements, in an amount equal to
the full replacement cost thereof (which amount shall be subject to Sublessor's
and Master Lessor's approval).  The insurance policy or policies shall name
Master Lessor and Sublessor and the lender's of either of them, if any, as
additional insureds and shall provide that the policy or policies may not be
cancelled on less than thirty (30) days prior written notice to Master Lessor,
Sublessor and the lenders of either of them.  If Sublessee fails to carry the
insurance or to furnish Sublessor with copies of all the policies after a
request to do so, Sublessor shall have the right to obtain the insurance and
collect the costs thereof from Sublessee as additional rent.

    b.        In addition to the above referenced insurance, Sublessee shall
maintain liability insurance coverage as required by paragraph 14. of the Master
Lease which has been incorporated into this Sublease by reference. Each policy
of insurance which Sublessee is required to maintain pursuant to this Lease
shall name both Sublessor and Master Lessor as additional insureds 

                                       8

<PAGE>

(including cross-liability endorsements). Sublessee's insurance coverage shall 
be primary and non-contributory as respects any insurance maintained by 
Sublessor and/or Master Lessor.  Tenant shall deliver evidence of the coverage 
required hereunder (i) within seven (7) days after execution and delivery of 
this Sublease by Sublessor and Sublessee and (ii) within ten (10) days of the 
renewal date for each policy of insurance required hereunder.

    c.        Pursuant to the terms of the Master Lease as provided in
paragraph 25 of the Addendum thereto, Master Lessor is obligated to maintain
certain insurance coverage with respect to certain perils and to maintain a
certain level of liability coverage.  Sublessor's sole obligation to Sublessee
with respect to Master Lessor's obligations pursuant to said paragraph 25 shall
be to request performance of such obligations by Master Lessor.  In the event
Master Lessor breaches its obligations, Sublessor will assign to Sublessee its
right to enforce such obligation and shall otherwise cooperate with Sublessee in
connection therewith, provided, however, Sublessee, at its sole cost and
expense, shall be responsible for enforcement thereof without reimbursement from
Sublessor.

12.      DAMAGE OR DESTRUCTION.  

    a.        MASTER LESSOR HAS OBLIGATION TO RESTORE.  If the Sublease
Premises are damaged or destroyed, Master Lessor has the obligation pursuant to
paragraph 12 of the Master Lease to promptly and diligently repair the Premises
unless Master Lessor has the right to terminate.  If Master Lessor fails to
perform its obligations pursuant to paragraph 12 of the Master Lease,
Sublessor's sole obligation to Sublessee shall be to request performance of such
obligations by Master Lessor.  In the event Master Lessor breaches its
obligations, Sublessor will assign to Sublessee its right to enforce such
obligation, provided, however, Sublessee, at its sole cost and expense, shall be
responsible for enforcement thereof without reimbursement from Sublessor.

    b.        TERMINATION OF MASTER LEASE.  If the Master Lease terminates
pursuant to paragraph 12 of the Master Lease, this 

                                       9

<PAGE>

Sublease shall terminate concurrently with the termination of the Master Lease.

    c.        SUBLESSEE NOTICE; RIGHT TO TERMINATE.  Within twenty (20) days
following written request from Sublessor, Sublessee shall give notice to
Sublessor in writing whether Sublessee agrees to continue this Sublease in
effect if Master Lessor reasonably determines that the repair of the Premises or
the Building cannot be completed within two hundred seventy (270) days after the
casualty.  If Sublessee does not so agree to continue this Sublease in effect,
then Sublessor may elect to terminate the Master Lease and this Sublease. If
Sublessee agrees to continue this Sublease in effect as aforesaid, then
Sublessor shall have no right to exercise its right to terminate the Master
Lease or this Sublease.  If (i) Master Lessor reasonably determines that the
repair of the Premises or the Building cannot be completed within two hundred
seventy (270) days after the casualty, (ii) neither Master Lessor nor Sublessor
have elected to terminate the Master Lease, and (iii) Sublessee agrees to
continue this Sublease in effect notwithstanding the time to reconstruct, then
this Sublease shall continue in effect, and Sublessee shall fulfill all of the
obligations of Sublessor pursuant to the provisions of paragraph 12 of the
Master Lease.

    d.        LIMITED OBLIGATION TO REPAIR. Master Lessor's obligation, should
Master Lessor elect or be obligated to repair or rebuild, shall be limited to
replacing/restoring the building shell and Building systems so that the Building
shell and Building systems as repaired and restored are comparable (in scope of
improvements) to the Building shell and building systems which were in existence
on the Master Lease Commencement Date.  Master Lessor shall have no obligation
to replace or restore the Tenant Improvements or any other alterations installed
by Sublessor or Sublessee.  If this Sublease has not been terminated, Sublessee
shall be obligated to (i) with respect to those portions of the Premises which
are damaged and were built-out for office use as of the Master Lease
Commencement Date, either: (A) promptly buildout those portions with new tenant
improvements approved by Master Lessor and Sublessor in accordance with EXHIBIT
D to the Master Lease, and spend an amount equal to or greater than the Building
Standard Improvements Allowance (defined below) on the build-out; 

                                       10

<PAGE>

(B) promptly build-out those portions with new tenant improvements approved by 
Master Lessor and Sublessor in accordance with EXHIBIT D and spend an amount 
less than the Building Standard Improvement Allowance (in which case promptly 
upon completion of the Tenant Improvements, Sublessee shall pay to Sublessor 
the difference between the amount spent by Sublessee for new tenant improvements
and the Building Standard Improvements Allowance); or (C) pay to Sublessor an 
amount equal to the Building Standard Improvements Allowance multiplied by the 
rentable square footage of the office space so affected; and (ii) with respect 
to those portions of the Premises which are damaged, but were not built out for 
office use as of the Commencement Date, either: (A) promptly construct new 
tenant improvements approved by Master Lessor and Sublessor in accordance with 
EXHIBIT D in the space so affected (and expend no less than the Tenant 
Improvement Allowance for the improvements); (B) promptly construct new tenant 
improvements approved by Master Lessor and Sublessor in accordance with EXHIBIT 
D, in the space so affected, expending less than the Tenant Improvement 
Allowance (in which case Tenant shall pay to Sublessor the difference between 
the amount expended and the Tenant Improvement Allowance promptly upon 
completion of the construction); or (C) pay to Sublessor an amount equal to the 
Tenant Improvement Allowance applicable to the affected space.  Any payment by 
Tenant to Sublessor in accordance with subsections (i) (C) or (ii) (C) of the 
preceding sentence must be made upon the earlier of ten (10) days following 
Sublessee's receipt of insurance proceeds thereof, or ninety (90) days after the
occurrence of the damage or destruction, or Sublessee shall be deemed to have 
elected to restore and rebuild the portions of the Premises which were damaged.
As used herein, the term "Building Standard Improvements Allowance" shall have 
the meaning set forth in paragraph 12.c. of the Master Lease.  Sublessee shall 
at its sole cost and expense restore all improvements made by Sublessee.

    e.        ABATEMENT OF RENT.  Rent under this Sublease shall abate to the
same extent as the Rent owing by Sublessor under the Master Lease abates.

    f.        DAMAGE NEAR END OF TERM.  In addition to the rights to terminate
specified in subparagraph 12.c. of this Sublease, either Sublessor or Sublessee
shall have the right to cancel and 

                                       11

<PAGE>

terminate this Sublease as of the date of the occurrence of destruction or 
damage if the Premises or the Building is substantially destroyed or damaged 
(i.e., there is damage or destruction which Landlord determines would require 
more than four (4) months to repair) and made untenantable during the last 
twelve (12) months of the term of the Master Lease. Sublessor and Sublessee 
shall give notice of its election to terminate this Sublease under this 
subsection f. within thirty (30) days after Master Lessor or Sublessor 
determines that the damage or destruction would require more than four (4) 
months to repair.  If either Master Lessor or Sublessor elect to terminate the 
Master Lease pursuant to paragraph 12.e. of the Master Lease, this Sublease
shall terminate concurrently with the termination of the Master Lease.  If
neither Master Lessor nor Sublessor terminates the Master Lease and if either
Sublessor or Sublessee elects to terminate this Sublease, the repair of the
damage shall be governed by subsections 12.c. or 12.e., as the case may be. 

    g.        INSURANCE PROCEEDS.  If this Sublease is terminated, Master
Lessor and Sublessor may each keep all their respective insurance proceeds
resulting from the damage except for those proceeds, if any, which specifically
insured Sublessee's personal property and trade fixtures which Sublessee has a
right or obligation to remove upon the expiration of the Sublease term. 
Sublessor shall be entitled to receive from Sublessee the proceeds of insurance
carried by Sublessee with respect to Tenant Improvements or other alterations
installed in the Sublease Premises by Sublessor or at Sublessor's expense. To
the extent that Sublessee has paid for any alterations regardless of whether the
alterations may become the property of Sublessor upon termination of this
Sublease, Sublessee shall receive any portion of the insurance proceeds payable
with respect to the then unamortized cost (based on an 8 year, straight line,
amortization schedule) for the applicable alterations, reduced by the amounts
necessary to pay off any Equipment Lease or other lien against the applicable
alteration, and the balance of the proceeds, if any, will be payable to
Sublessor.  With respect to those Alterations which  Sublessee is obligated to
remove at the end of the Sublease term which are the property of Sublessee, all
proceeds shall be paid to Sublessee.

                                       12

<PAGE>

    h.        UNINSURED CASUALTY.  If the Master Lease terminates pursuant to
the provisions of paragraph 12.g. of the Master Lease, this Sublease shall
terminate.  Sublessor shall have no obligation to deposit funds with Master
Lessor pursuant to said paragraph 12.g.; provided, however, if Sublessor and
Sublessee have so agreed that Sublessee will provide the funds for deposit with
Master Lessor in that amount which Sublessor is permitted to contribute to
repairs in order to keep the Master Lease from terminating pursuant to paragraph
12.g., then upon Sublessee providing such funds, this Sublease shall continue in
effect.

13.      EMINENT DOMAIN.  If all or any part of the premises is taken for
public or quasi-public use by a governmental authority under the power of
eminent domain or is conveyed to a governmental authority in lieu of such
taking, and if the taking or conveyance causes the remaining part of the
Premises to be untenantable and inadequate for use by Sublessee for the purpose
for which they were leased, then Sublessee, at its option and by giving notice
within fifteen (15) days after the taking, may terminate this Sublease as of the
date Sublessee is required to surrender possession of the Premises.  If a part
of the Premises is taken or conveyed but the remaining part is tenantable and
adequate for Sublessee's use, then this Sublease shall be terminated as to the
part taken or conveyed as of the date Sublessee surrenders possession; Master
Lessor is obligated, at no cost or expenses to Sublessor or Sublessee, to
restore the Premises (other than any Tenant Improvements) to a complete
architectural unit of a design comparable to the design of the Premises (other
than any Tenant Improvements or alterations) immediately prior to the
condemnation, and the Rent shall be reduced based on any decrease in use to
Sublessee of the Premises.  All compensation awarded for the taking or
conveyance shall be the property of Master Lessor and Sublessor, as there
interests may appear, and Sublessee hereby assigns to Sublessor all its right,
title and interest in and to the award, unless the governmental authority makes
only one (1) award, and the award contains compensation for the value of moving
expenses, Sublessee's personal property, trade fixtures and alterations
(including the Tenant Improvements), in which case, subject to the rights of any
mortgagee or beneficiary of a deed of trust holding a lien on the Property,
Sublessee shall be entitled to the compensation paid for Sublessee's moving
expenses, trade 

                                       13

<PAGE>

fixtures, personal property and the portion of the award attributable to the 
then unamortized cost of alterations and improvements constructed at Sublessee's
expense (which are to be amortized on a straight line basis over the initial 
term of the Sublease).  Sublessee shall have the right, however, to recover 
from the governmental authority, but not from Sublessor or Master Lessor, except
as provided in the preceding sentence, such compensation as may be awarded to 
Sublessee on account of the interruption of Sublessee's business, moving and 
relocation expenses and removal of Sublessee's trade fixtures and personal 
property.

14.      ASSIGNMENT AND SUBLETTING.  Notwithstanding any provision of this
Sublease to the contrary, if Sublessor consents to a sublet, Sublessee shall pay
to Sublessor on a monthly basis as additional Rent, on the date Base Rent is
due, an amount equal to fifty percent (50%) of the amount by which the rent
payable to Sublessee ("Subrent") under the sublease exceeds the rent due for the
applicable portion of the Premises after deducting from the Subrent (A) the
reasonable out-of pocket costs incurred by Sublessee for brokerage commissions
and tenant concessions (which concessions are not reflected in the reduced
Subrent) and (B) the costs of any additional improvements constructed by
Sublessee in connection with the sublease (amortized on a straight line basis
over the term of the sublease).

15.      ACCESS TO PREMISES.  Master Lessor shall have the same right of access
to the Premises as Sublessor.

16.      SURRENDER AT END OF TERM.  Sublessee shall surrender the Premises to
Sublessor in its condition as of the Commencement Date, except for any
alterations Sublessee is not required to remove, normal wear and tear, acts of
God, damage, destruction (except to the extent Sublessee is obligated to restore
the same under paragraph 12 of this Sublease) and eminent domain covered by the
provisions of this Sublease.  Sublessee shall remove from the premises all of
Sublessee's personal property and trade fixtures and any alterations and
improvements Sublessee is required to remove, and shall repair all damage caused
by the removal.  Sublessee shall indemnify Sublessor against all loss or
liability resulting from delay by Sublessee in so surrendering the Premises,

                                       14

<PAGE>

including without limitation, any claims made by any succeeding tenant, losses
to Sublessor due to lost opportunities to lease to a succeeding tenant, and
attorneys' fees and costs.  Sublessee shall have no obligation to remove any
fixtures, Alterations or personal property placed or installed in the Premises
prior to the Commencement Date hereof.

17.      PHASE I ENVIRONMENTAL REPORT; SUBLESSOR INDEMNITY RE: HAZARDOUS
MATERIALS.  

    a.        Sublessee may, at its own expense, obtain a Phase I environmental
investigation report with respect to the Premises.  Sublessor will endeavor to
obtain and provide to Sublessee copies of environmental investigation reports
referred to in paragraph 9.e. of the Master Lease.

    b.        Sublessor shall indemnify, defend and hold Sublessee harmless
from and against any claim, damage, loss, liability, cost or expense (including
reasonable attorneys' fees) arising out of any spill or release of any Hazardous
Materials (as defined in paragraph 9.d. of the Master Lease which has been
incorporated by reference into this Sublease) on or about the Premises by
Sublessor, its employees, agents or contractors during the period of time
Sublessor or Khepri Pharmaceuticals, Inc. have occupied the Premises.

    c.        Sublessor is entitled to indemnification from the Master Lessor
as provided in paragraph 9.e. of the Master Lease. To the extent such
indemnification may redound to the benefit of Sublessee, Sublessor agrees to
cooperate with Sublessee to enforce such indemnity obligation against Master
Lessor; provided, however, Sublessee shall pay any and all costs incurred by
Sublessor or Sublessee in connection with the enforcement thereof for the
benefit of Sublessee.

18.      SIGNS.  Master Lessor shall have the same approval rights with respect
to signs as Sublessor.

19.      HOLDING OVER.  This Sublease shall terminate without further notice at
the expiration of the Sublease term.  Any holding over by Sublessee after
expiration or sooner termination of this Lease 


                                       15

<PAGE>

without the consent of Sublessor shall be construed to be a tenancy at 
sufferance.  Rent for the Premises during any tenancy at sufferance, or if 
Sublessor shall have consented to Sublessee's holding over, shall be at a rate 
equal to 150% of the Base Rent for the last month of the term, and shall 
otherwise be on the terms and conditions herein specified insofar as applicable,
including, without limitation, those providing for Additional Rent.

20.      BROKERS.  For purposes of paragraph 29 of the Master Lease as
incorporated into this Sublease, Cornish & Carry Commercial-Oncor International
is the only broker to whom a commission is owing, which commission shall be paid
by Sublessor.

21.      NOTICES.  All notices or demands of any kind required to be given by
Sublessor or Sublessee hereunder shall be in writing and shall be deemed
delivered forty-eight (48) hours after depositing the notice or demand in the
United States Mail, certified or registered, postage prepaid, addressed to the
Sublessor or Sublessee respectively at the addresses set forth after their
signatures at the end of this Sublease.  All rent and other payments due under
this Sublease or the Master Lease shall be made by Sublessee to Sublessor at the
same address.

22.      CONSENT OF MASTER LESSOR.  This Sublease is contingent upon Sublessor
obtaining the consent of the Master Lessor.

    IN WITNESS WHEREOF, the undersigned have executed this Sublease as of the
dates set forth below.

SUBLESSOR:

ARRIS PHARMACEUTICAL CORPORATION,
a Delaware corporation 


By:  /s/ Daniel H. Petree
     ----------------------------

Its:     Exec. V.P.                      Date 
     ----------------------------             ------------
385 Oyster Point Blvd., Suite 3

                                       16
<PAGE>


South San Francisco, CA  94080 

                                       17

<PAGE>

SUBLESSEE:

FIBROGEN, INC.,
a Delaware corporation


By:  /s/ Thomas B. Neff                Date  23 Aug 96
    ----------------------------            -----------------
    Thomas B. Neff, President
                   

260 Littlefield Avenue, Suite A
South San Francisco, CA  94080
 
                                       18

<PAGE>

                                     EXHIBIT "A"

THE FOLLOWING FIXTURES AND EQUIPMENT SHALL REMAIN WITH THE PREMISES AND SHALL BE
SURRENDERED BY SUBLESSEE AT THE EXPIRATION OR EARLIER TERMINATION OF THE
SUBLEASE:

    Portable Class 100 Clean Rooms (2)
    Chemilox Boiler
    Chemical Fume Hoods (6)
    Cold Room
    DI Water System with R/O module
    Generator
    Casework

                                       19


<PAGE>

                                 EXHIBIT 10.42
                                PROMISSORY NOTE



$750,000                                         South San Francisco, California
                                                               September 3, 1996


     FOR VALUE RECEIVED, the undersigned hereby unconditionally promises to pay
to the order of ARRIS PHARMACEUTICAL CORPORATION, a Delaware corporation (the
"Company"), at the offices of the Company, 385 Oyster Point Boulevard, South San
Francisco, California, or at such other place as the holder hereof may designate
in writing, in lawful money of the United States of America and in immediately
available funds, the principal sum of Seven Hundred Fifty Thousand Dollars
($750,000) together with interest accrued from the date hereof on the unpaid
principal at the rate of 6.02% per annum, or the maximum rate permissible by law
(which under the laws of the State of California shall be deemed to be the laws
relating to permissible rates of interest on commercial loans), whichever is
less, compounded annually, as follows:

          PRINCIPAL REPAYMENT.  The outstanding principal amount hereunder shall
     be DUE AND PAYABLE IN FULL ON SEPTEMBER 3, 1998; and

          INTEREST PAYMENTS.  Interest shall be payable IN ARREARS ON THE
     PRINCIPAL REPAYMENT DATE and shall be calculated on the basis of a 365-day
     year for the actual number of days elapsed;

PROVIDED, HOWEVER, that the parties agree that if the undersigned shall sell and
close on his property located at 3540 La Honda Road, San Gregorio, California,
prior to September 3, 1998, the undersigned shall make a reasonable, good faith
payment toward repayment of the principal and accrued interest due under this
Promissory Note as soon as reasonably practicable thereafter.  

     This Note may be prepaid at any time without penalty.  All money paid
toward the satisfaction of this Note shall be applied first to the payment of
interest as required hereunder and then to the retirement of the principal.

     The full amount of this Note is secured by a pledge of shares of Common
Stock of the Company, and is subject to all of the terms and provisions of the
Pledge Agreement of even date herewith between the undersigned and the Company.

     The undersigned hereby represents and agrees that the amounts due under
this Note are not consumer debt, and are not incurred primarily for personal,
family or household purposes, but are for business and commercial purposes only.


                                       1
<PAGE>

     The undersigned hereby waives presentment, protest and notice of protest,
demand for payment, notice of dishonor and all other notices or demands in
connection with the delivery, acceptance, performance, default or endorsement of
this Note. 

     The holder hereof shall be entitled to recover, and the undersigned agrees
to pay when incurred, all costs and expenses of collection of this Note,
including without limitation, reasonable attorneys' fees.

     This Note shall be governed by, and construed, enforced and interpreted in
accordance with, the laws of the State of California, excluding conflict of laws
principles that would cause the application of laws of any other jurisdiction.



                                       Signed /s/ John P. Walker
                                              ---------------------------------
                                                     John P. Walker






                                       2


<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM THE
CONSOLIDATED BALANCE SHEETS, STATEMENTS OF OPERATIONS AND STATEMENTS OF CASH
FLOWS INCLUDED IN THE COMPANY'S FORM 10-Q FOR THE PERIOD ENDED SEPTEMBER 30,
1996, AND IS QUALIFIED IN ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS
AND NOTES THERETO.
</LEGEND>
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   9-MOS
<FISCAL-YEAR-END>                          DEC-31-1996
<PERIOD-START>                             JAN-01-1996
<PERIOD-END>                               SEP-30-1996
<CASH>                                           4,407
<SECURITIES>                                    61,984
<RECEIVABLES>                                        0
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                                47,993
<PP&E>                                          16,789
<DEPRECIATION>                                 (8,572)
<TOTAL-ASSETS>                                  77,897
<CURRENT-LIABILITIES>                           15,743
<BONDS>                                              0
                                0
                                          0
<COMMON>                                        14,268
<OTHER-SE>                                      47,316
<TOTAL-LIABILITY-AND-EQUITY>                    77,897
<SALES>                                              0
<TOTAL-REVENUES>                                16,195
<CGS>                                                0
<TOTAL-COSTS>                                   18,126
<OTHER-EXPENSES>                                 4,109
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 486
<INCOME-PRETAX>                                (4,328)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                            (4,328)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   (4,328)
<EPS-PRIMARY>                                    (.34)
<EPS-DILUTED>                                    (.34)
        

</TABLE>


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