ARRIS PHARMACEUTICAL CORP/DE/
SC 13G/A, 1997-02-14
PHARMACEUTICAL PREPARATIONS
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                                 UNITED STATES
                      SECURITIES AND EXCHANGE COMMISSION
                            Washington, D.C. 20549
                                       
                                 SCHEDULE 13G
                                       
                   Under the Securities Exchange Act of 1934
                                       
                              (Amendment No. 2 )*
                                       
                       Arris Pharmaceutical Corporation
                               (Name of Issuer)
                                       
                                 Common Stock
                        (Title of Class of Securities)
                                       
                                   04269W107
                                (CUSIP Number)
                                       
Check the following box if a fee is being paid with the statement |_|. (A fee is
not required only if the filing person: (1) has a previous statement on file
reporting beneficial ownership of more than five percent of the class of
securities described in Item 1 and (2); has filed no amendment subsequent
thereto reporting beneficial ownership of five percent or less of such class.)
(See Rule 13d-7).

*The remainder of this cover page shall be filled out for a reporting person's
initial filing on this form with respect to the subject class of securities, and
for any subsequent amendment containing information which would alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

<PAGE>

CUSIP No.  04269W107                  13G                   Page 2 of 16 Pages
         
    1       NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Venrock Associates
            I.R.S. #13-6300995


    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  /x/
                                                                     (b)  / /


    3       SEC USE ONLY


    4       CITIZENSHIP OR PLACE OF ORGANIZATION

              New York, U.S.A.


            NUMBER OF                 5      SOLE VOTING POWER

             SHARES                          0

          BENEFICIALLY                6      SHARED VOTING POWER         
                                   
            OWNED BY                         0             
                                   
              EACH                                   
            REPORTING                 7      SOLE DISPOSITIVE POWER      
                                   
             PERSON                          0                           
              WITH                                   
                                   
                                      8      SHARED DISPOSITIVE POWER    
                                                                         
                                             0                     

    9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            0


    10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES*




    11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9


            0.00%


    12      TYPE OF REPORTING PERSON*

            PN




                      *SEE INSTRUCTION BEFORE FILLING OUT!

                          Page 2 of 16 pages


<PAGE>




CUSIP No.  04269W107                  13G                   Page 3 of 16 Pages
         




    1       NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Venrock Associates II, L.P.
            I.R.S. #13-3844754


    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  /x/
                                                                     (b)  / /


    3       SEC USE ONLY


    4       CITIZENSHIP OR PLACE OF ORGANIZATION

               New York, U.S.A.


             NUMBER OF                 5      SOLE VOTING POWER

             SHARES                          0

          BENEFICIALLY                6      SHARED VOTING POWER         
                                   
            OWNED BY                         0                     
                                   
              EACH                                   
            REPORTING                 7      SOLE DISPOSITIVE POWER      
                                   
             PERSON                          0                           
              WITH                                   
                                   
                                      8      SHARED DISPOSITIVE POWER    
                                                                         
                                             0                     


    9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            0


    10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES*




    11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9


            0.00%


    12      TYPE OF REPORTING PERSON*

            PN




                      *SEE INSTRUCTION BEFORE FILLING OUT!

                          Page 3 of 16 pages


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CUSIP No.  04269W107                  13G                   Page 4 of 16 Pages
         




    1       NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Peter O. Crisp
            ###-##-####


    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  /x/
                                                                     (b)  / /


    3       SEC USE ONLY


    4       CITIZENSHIP OR PLACE OF ORGANIZATION

               U.S.A.


            NUMBER OF                 5      SOLE VOTING POWER

             SHARES                          25,409

          BENEFICIALLY                6      SHARED VOTING POWER         
                                   
            OWNED BY                         0                     
                                   
              EACH                                   
            REPORTING                 7      SOLE DISPOSITIVE POWER      
                                   
             PERSON                          25,409                           
              WITH                                   
                                   
                                      8      SHARED DISPOSITIVE POWER    
                                                                         
                                             0                              


    9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            25,409


    10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES*




    11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9


            0.18%


    12      TYPE OF REPORTING PERSON*

            IN




                      *SEE INSTRUCTION BEFORE FILLING OUT!

                          Page 4 of 16 pages


<PAGE>




CUSIP No. 04269W107                   13G                   Page 5 of 16 Pages
         



    1       NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Anthony B. Evnin
            ###-##-####


    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  /x/
                                                                     (b)  / /


    3       SEC USE ONLY


    4       CITIZENSHIP OR PLACE OF ORGANIZATION

              U.S.A.


            NUMBER OF                 5      SOLE VOTING POWER

             SHARES                          25,330

          BENEFICIALLY                6      SHARED VOTING POWER         
                                   
            OWNED BY                         0                     
                                   
              EACH                                   
            REPORTING                 7      SOLE DISPOSITIVE POWER      
                                   
             PERSON                          25,330                           
              WITH                                   
                                   
                                      8      SHARED DISPOSITIVE POWER    
                                                                         
                                             0                     


    9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            25,330


    10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES*




    11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9


            0.18%


    12      TYPE OF REPORTING PERSON*

            IN




                      *SEE INSTRUCTION BEFORE FILLING OUT!

                          Page 5 of 16 pages


<PAGE>



CUSIP No. 04269W107                   13G                   Page 6 of 16 Pages
         

    1       NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            David R. Hathaway
            ###-##-####


    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  /x/
                                                                     (b)  / /


    3       SEC USE ONLY


    4       CITIZENSHIP OR PLACE OF ORGANIZATION

              U.S.A.


             NUMBER OF                 5      SOLE VOTING POWER

             SHARES                           15,395

          BENEFICIALLY                6      SHARED VOTING POWER         
                                   
            OWNED BY                         0                     
                                   
              EACH                                   
            REPORTING                 7      SOLE DISPOSITIVE POWER      
                                   
             PERSON                          15,395                           
              WITH                                   
                                   
                                      8      SHARED DISPOSITIVE POWER    
                                                                         
                                             0                     


    9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            15,395


    10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES*




    11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9


            0.11%


    12      TYPE OF REPORTING PERSON*

            IN




                      *SEE INSTRUCTION BEFORE FILLING OUT!

                          Page 6 of 16 pages


<PAGE>



CUSIP No.  04269W107                  13G                   Page 7 of 16 Pages
         



    1       NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Patrick F. Latterell
            ###-##-####


    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  /x/
                                                                     (b)  / /


    3       SEC USE ONLY


    4       CITIZENSHIP OR PLACE OF ORGANIZATION

               U.S.A.


             NUMBER OF                5      SOLE VOTING POWER

             SHARES                          21,401

          BENEFICIALLY                6      SHARED VOTING POWER         
                                   
            OWNED BY                         0                     
                                   
              EACH                                   
            REPORTING                 7      SOLE DISPOSITIVE POWER      
                                   
             PERSON                          21,407                           
              WITH                                   
                                   
                                      8      SHARED DISPOSITIVE POWER    
                                                                         
                                             0                     


    9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            21,401


    10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES*




    11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9


            0.15%


    12      TYPE OF REPORTING PERSON*

            IN




                      *SEE INSTRUCTION BEFORE FILLING OUT!

                          Page 7 of 16 pages


<PAGE>




CUSIP No.  04269W107                  13G                   Page 8 of 16 Pages
         




    1       NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Ted H. McCourtney
            ###-##-####


    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  /x/
                                                                     (b)  / /


    3       SEC USE ONLY


    4       CITIZENSHIP OR PLACE OF ORGANIZATION

               U.S.A.


            NUMBER OF                 5      SOLE VOTING POWER

             SHARES                          25,705

          BENEFICIALLY                6      SHARED VOTING POWER         
                                   
            OWNED BY                         0                     
                                   
              EACH                                   
            REPORTING                 7      SOLE DISPOSITIVE POWER      
                                   
             PERSON                          25,705                           
              WITH                                   
                                   
                                      8      SHARED DISPOSITIVE POWER    
                                                                         
                                             0                     


    9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            25,705


    10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES*




    11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9


            0.18%


    12      TYPE OF REPORTING PERSON*

            IN




                      *SEE INSTRUCTION BEFORE FILLING OUT!

                          Page 8 of 16 pages


<PAGE>




CUSIP No.  04269W107                  13G                   Page 9 of 16 Pages
         




    1       NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Ray A. Rothrock
            ###-##-####


    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  /x/
                                                                     (b)  / /


    3       SEC USE ONLY


    4       CITIZENSHIP OR PLACE OF ORGANIZATION

               U.S.A.


            NUMBER OF                 5      SOLE VOTING POWER

             SHARES                          0

          BENEFICIALLY                6      SHARED VOTING POWER         
                                   
            OWNED BY                         0
                                   
              EACH                                   
            REPORTING                 7      SOLE DISPOSITIVE POWER      
                                   
             PERSON                          0                           
              WITH                                   
                                   
                                      8      SHARED DISPOSITIVE POWER    
                                                                         
                                             0


    9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            0


    10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES*




    11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9


            0.00%


    12      TYPE OF REPORTING PERSON*

            IN




                      *SEE INSTRUCTION BEFORE FILLING OUT!

                          Page 9 of 16 pages


<PAGE>




CUSIP No.  04269W107                  13G                   Page 10 of 16 Pages
         




    1       NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Kimberley A. Rummelsburg
            ###-##-####


    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  /x/
                                                                     (b)  / /


    3       SEC USE ONLY


    4       CITIZENSHIP OR PLACE OF ORGANIZATION

              U.S.A.


            NUMBER OF                 5      SOLE VOTING POWER

             SHARES                          0

          BENEFICIALLY                6      SHARED VOTING POWER         
                                   
            OWNED BY                         1,800
                                   
              EACH                                   
            REPORTING                 7      SOLE DISPOSITIVE POWER      
                                   
             PERSON                          0                           
              WITH                                   
                                   
                                      8      SHARED DISPOSITIVE POWER    
                                                                         
                                             1,800

    9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            1,800


    10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES*




    11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9


            0.01%


    12      TYPE OF REPORTING PERSON*

            IN




                      *SEE INSTRUCTION BEFORE FILLING OUT!

                               Page 10 of 16 pages


<PAGE>




CUSIP No.  04269W107                  13G                   Page 11 of 16 Pages
         




    1       NAME OF REPORTING PERSON
            S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

            Anthony Sun
            ###-##-####


    2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*        (a)  /x/
                                                                     (b)  / /


    3       SEC USE ONLY


    4       CITIZENSHIP OR PLACE OF ORGANIZATION

               U.S.A.


            NUMBER OF                 5      SOLE VOTING POWER

             SHARES                          0

          BENEFICIALLY                6      SHARED VOTING POWER         
                                   
            OWNED BY                         22,912
                                   
              EACH                                   
            REPORTING                 7      SOLE DISPOSITIVE POWER      
                                   
             PERSON                          0                           
              WITH                                   
                                   
                                      8      SHARED DISPOSITIVE POWER    
                                                                         
                                             22,912                     


    9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

            22,912


    10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
            SHARES*




    11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9


            0.16%


    12      TYPE OF REPORTING PERSON*

            IN




                      *SEE INSTRUCTION BEFORE FILLING OUT!

                               Page 11 of 16 pages


<PAGE>




                  Introduction:     This Amendment No. 2 amends a Statement on
Schedule 13G (the "Schedule") filed with the Securities and Exchange Commission
on February 15, 1994 on behalf of Venrock Associates, a limited partnership
organized under the laws of the State of New York, Peter O. Crisp, Anthony B.
Evnin,  David R. Hathaway, Patrick F. Latterell, Ted H. McCourtney, Kimberley A.
Rummelsburg and Anthony Sun in respect of shares of Common Stock of Arris
Pharmaceutical Corporation.  This Schedule was amended by Amendment No. 1, filed
on February 14, 1996, on behalf of Venrock Associates II, L.P., a limited
partnership organized under the laws of the State of New York, as well as the
parties named above.

                  The Schedule is amended as follows:

Item 1(a)         Name of Issuer

                  Arris Pharmaceutical Corporation

Item 1(b)         Address of Issuer's Principal Executive Offices

                  385 Oyster Point Boulevard, Suite 3
                  South San Francisco, California 94080-2603

Item 2(a)         Name of Person Filing

                  Venrock Associates ("Venrock")
                  Venrock Associates II, L.P. ("Venrock II")
                  Peter O. Crisp
                  Anthony B. Evnin
                  David R. Hathaway
                  Patrick F. Latterell
                  Ted H. McCourtney
                  Ray A. Rothrock
                  Kimberley A. Rummelsburg
                  Anthony Sun

Item 2(b)         Address of Principal Business Office or, if none, Residence

                  30 Rockefeller Plaza
                  Room 5508
                  New York, New York 10112

Item 2(c)         Citizenship

                  Venrock and Venrock II are limited partnerships organized in
                  the State of New York. Peter O. Crisp, Anthony B. Evnin, David
                  R. Hathaway, Patrick F. Latterell, Ted H. McCourtney, Ray A.
                  Rothrock, Kimberley A. Rummelsburg and Anthony Sun are General
                  Partners of Venrock and Venrock II and all are citizens of the

                  United States of America.

Item 2(d)         Title of Class of Securities

                  Common Stock

Item 2(e)         CUSIP Number

                  04269W107

                          Page 12 of 16 pages


<PAGE>



Item 3            Not applicable.

Item 4            Ownership

                  (a) and (b)

                  Venrock and Venrock II beneficially own no shares of the
                  outstanding shares of common stock.

                  Peter O. Crisp beneficially owns 25,409 shares or 0.18% of the
                  outstanding shares of common stock. Anthony B. Evnin
                  beneficially owns 25,330 shares or 0.18% of the outstanding
                  shares of common stock. David R. Hathaway beneficially owns
                  15,395 shares or 0.11% of the outstanding shares of common
                  stock. Patrick F. Latterell beneficially owns 21,401 shares or
                  0.15% of the outstanding shares of common stock. Ted H.
                  McCourtney beneficially owns 25,705 shares or 0.18% of the
                  outstanding shares of common stock. Ray A. Rothrock
                  beneficially owns no shares or 0.00% of the outstanding shares
                  of common stock. Kimberley A. Rummelsburg beneficially owns
                  1,800 shares or 0.01% of the outstanding shares of common
                  stock. Anthony Sun beneficially owns 22,912 shares or 0.16 %
                  of the outstanding shares of common stock.

                  (c)

                  Peter O. Crisp has sole voting and dispositive power over
                  25,409 shares of common stock. Anthony B. Evnin has sole
                  voting and dispositive power over 25,330 shares of common
                  stock. David R. Hathaway has sole voting and dispositive power
                  over 15,395 shares of common stock. Patrick F. Latterell has
                  sole voting and dispositive power over 21,401 shares of common
                  stock. Ted H. McCourtney has sole voting and dispositive power
                  over 25,705 shares of common stock. Ray A. Rothrock has no
                  voting or dispositive power over any shares of common stock.
                  Kimberley A. Rummelsburg has shared voting and dispositive
                  power over 1,800 shares of common stock. Anthony Sun has

                  shared voting and dispositive power over 22,912 shares of
                  common stock.

Item 5            Ownership of Five Percent or Less of a Class


                  This Amendment No. 2 to the Schedule is being filed to report
                  the fact that each of the reporting persons has ceased to be
                  the beneficial owner of more than five percent of the
                  outstanding shares of common stock.

Item 6            Ownership of More than Five Percent on Behalf of Another
                  Person


                  No person, other than the General Partners of Venrock and
                  Venrock II, has the right to receive or the power to direct
                  the receipt of dividends from, or the proceeds from the sale
                  of, the shares of common stock owned by Venrock and Venrock
                  II.

Item 7            Identification and Classification of the Subsidiary Which
                  Acquired the Security Being Reported on By the Parent Holding
                  Company
                  

                  Not applicable.

Item 8            Identification and Classification of Members of the Group


                  This schedule is being filed pursuant to Rule 13d-1(c). The
                  identities of the eight General Partners of Venrock and
                  Venrock II are stated in Item 2.

Item 9            Notice of Dissolution of Group


                  Not applicable.

                          Page 13 of 16 pages


<PAGE>




Item 10           Certification

                  Not applicable.

                          Page 14 of 16 pages


<PAGE>


                                    SIGNATURE

                  After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this Statement in true,
complete and correct.



February 14, 1997                      VENROCK ASSOCIATES

                                       By: /s/ Ted H. McCourtney
                                           -------------------------------
                                       Ted H. McCourtney
                                       General Partner

February 14, 1997                      VENROCK ASSOCIATES II, L.P.


                                       By: /s/ Ted H. McCourtney
                                           -------------------------------
                                       Ted H. McCourtney
                                       General Partner

February 14, 1997                      GENERAL PARTNERS

                                       /s/ Peter O. Crisp
                                       -----------------------------------
                                       Peter O. Crisp
                                               
                                       /s/ Anthony B. Evnin
                                       -----------------------------------
                                       Anthony B. Evnin
                                               
                                       /s/ David R. Hathaway
                                       -----------------------------------
                                       David R. Hathaway
                                               
                                       /s/ Patrick F. Latterell
                                       -----------------------------------
                                       Patrick F. Latterell
                                               


                                       /s/ Ted H. McCourtney
                                       -----------------------------------
                                       Ted H. McCourtney

                                       /s/ Ray A. Rothrock
                                       -----------------------------------
                                       Ray A. Rothrock

                                       /s/ Kimberley A. Rummelsburg
                                       -----------------------------------
                                       Kimberley A. Rummelsburg

                                       /s/ Anthony Sun
                                       -----------------------------------
                                       Anthony Sun


<PAGE>

                                                                   Exhibit 1

                                    AGREEMENT

                  Pursuant to Rule 13d-1(f) promulgated pursuant to the
Securities Exchange Act of 1934, as amended, the undersigned agree that the
attached Schedule 13G is being filed on behalf of each of the undersigned.

February 14, 1997                      VENROCK ASSOCIATES

                                       By: /s/ Ted H. McCourtney
                                           -------------------------------
                                       Ted H. McCourtney
                                       General Partner

February 14, 1997                      VENROCK ASSOCIATES II, L.P.


                                       By: /s/ Ted H. McCourtney
                                           -------------------------------
                                       Ted H. McCourtney
                                       General Partner

February 14, 1997                      GENERAL PARTNERS

                                       /s/ Peter O. Crisp
                                       -----------------------------------
                                       Peter O. Crisp
                                               
                                       /s/ Anthony B. Evnin
                                       -----------------------------------
                                       Anthony B. Evnin
                                               
                                       /s/ David R. Hathaway
                                       -----------------------------------
                                       David R. Hathaway
                                               
                                       /s/ Patrick F. Latterell
                                       -----------------------------------
                                       Patrick F. Latterell
                                               


                                       /s/ Ted H. McCourtney
                                       -----------------------------------
                                       Ted H. McCourtney

                                       /s/ Ray A. Rothrock
                                       -----------------------------------
                                       Ray A. Rothrock

                                       /s/ Kimberley A. Rummelsburg
                                       -----------------------------------
                                       Kimberley A. Rummelsburg

                                       /s/ Anthony Sun
                                       -----------------------------------
                                       Anthony Sun




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