AFFYMETRIX INC
RW, 1997-11-04
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>

                              November 4, 1997


VIA EDGAR
- ---------


Securities and Exchange Commission
450 Fifth Street, N.W.
Washington, DC 20549


                              Affymetrix, Inc.
              Registration Statement on Form S-3 (No. 333-38167)
              --------------------------------------------------

Ladies/Gentlemen:

     Pursuant to Rule 477 of the Securities Act of 1933, Affymetrix, Inc. 
("Registrant") hereby requests withdrawal of the above-referenced 
Registration Statement (the "Registration Statement") filed with the 
Securities and Exchange Commission on October 17, 1997. The Registrant is 
requesting withdrawal of the Registration Statement due to recent market 
volatility and current market conditions. Because of these conditions, we 
have concluded that it is neither in the best interest of the Company nor its 
shareholders to proceed with the offering at this time. No securities have 
been sold under the Registration Statement and all activity in pursuit of the 
offering has been discontinued.

     Please provide to Registrant and Registrant's legal counsel a copy of 
the order granting the withdrawal of the Registration Statement as soon as 
possible.

     Please contact either the undersigned at (408) 731-5919 or Stephen 
Ferruolo of Heller Ehrman White & McAuliffe, legal counsel to the Registrant, 
at (650) 324-7141, if you have any questions regarding the withdrawal of the 
Registration Statement.

                                 Very truly yours,

                                 /s/ Edward M. Hurwitz

                                 Edward M. Hurwitz
                                 Vice President and
                                 Chief Financial Officer

cc:  Karen Garnett, Esq.
     Nasdaq Stock Market
     Stephen C. Ferruolo, Esq.



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