AFFYMETRIX INC
8-K, 1999-09-28
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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                       SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549




                                    FORM 8-K



                                 CURRENT REPORT


                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934

Date of Report (Date of earliest event reported): September 14, 1999
                                                  -----------------------------

                                Affymetrix, Inc.
- -------------------------------------------------------------------------------
             (Exact Name of Registrant as Specified in its Charter)


          Delaware                     0-28218             77-0319159
- -----------------------------        ------------      -------------------
(State or Other Jurisdiction)        (Commission         (IRS Employer
         of Incorporation            File Number)      Identification No.)


3380 Central Expressway, Santa Clara, CA                   95051
- -------------------------------------------------------------------------------
(Address of Principal Executive Offices)                 (Zip Code)


Registrant's telephone number, including area code: (408) 731-5000
                                                    ---------------------------

                                 Not applicable
- -------------------------------------------------------------------------------
          (Former Name or Former Address, if Changed Since Last Report)


<PAGE>

Item 5.  Other Events.
         ------------

         Affymetrix, Inc., a Delaware corporation (the "Company"), issued one
press release on September 14, 1999, and two press releases on September 17,
1999 in connection with the private placement of its 5% Convertible Subordinated
Notes due 2006.


Item 7.  Financial Statements, Pro Forma Financial Information and Exhibits.
         ------------------------------------------------------------------

Exhibit
Number    Description
- -------------------------------------------------------------------------------

 99.1     Press Release dated September 14, 1999.

 99.2     Press Release dated September 17, 1999.

 99.3     Press Release dated September 17, 1999.


                                      -2-

<PAGE>


                                   SIGNATURES

                  Pursuant to the requirements of the Securities Exchange Act of
1934, the Registrant has duly caused this report to be signed on its behalf by
the undersigned, thereunto duly authorized.


                                         AFFYMETRIX, INC.



                                         By: /s/ Vernon A. Norviel
                                             ----------------------------------
                                             Name: Vernon A. Noviel
                                             Title: Senior Vice President,
                                                    General Counsel and
                                                    Secretary

Date: September 27, 1999

                                      -3-

<PAGE>


                                  EXHIBIT INDEX


  Exhibit Number                   Description
  --------------                   -----------

       99.1          Press Release dated September 14, 1999.
       99.2          Press Release dated September 17, 1999.
       99.3          Press Release dated September 17, 1999.


FOR IMMEDIATE RELEASE

Contact:          Affymetrix, Inc.
                  ----------------
                  Edward M. Hurwitz            Anne Bowdidge
                  Vice President and           Associate Director
                  Chief Financial Officer      of Investor Relations
                  (408) 731-5000               (408) 731-5925


                AFFYMETRIX, INC. ANNOUNCES PROPOSED $100 MILLION
                       CONVERTIBLE SUBORDINATED NOTE OFFER

SANTA CLARA, CA -SEPTEMBER 14, 1999- Affymetrix,  Inc., (NASDAQ: AFFX) announced
today that it proposes to make a private offering of $100 million of Convertible
Subordinated  Notes due 2006 (the "Notes") with an option to issue an additional
$25 million of Notes

The Notes will be convertible into Common Stock, at the option of the holder, at
a price to be  determined.  The  Company  expects to complete  this  offering in
September, 1999.

The Notes have not been registered under the Securities Act of 1933, as amended,
or  applicable  state  securities  laws,  and unless so  registered,  may not be
offered or sold in the United States, except pursuant to an applicable exemption
from the  registration  requirements  of the Securities Act of 1933, as amended,
and applicable state securities laws.

This press release shall not constitute an offer to sell or the  solicitation of
an offer to buy the Notes. This press release is being issued pursuant to and in
accordance with Rule 135c under the Securities Act of 1933, as amended.

Affymetrix has developed and intends to establish its GeneChip(R)  system as the
platform  of choice  for  acquiring,  analyzing  and  managing  complex  genetic
information  in order to improve the  diagnosis,  monitoring  and  treatment  of
disease.  The Company's  GeneChip system consists of disposable DNA probe arrays
containing gene sequences on a chip,  reagents for use with the probe arrays,  a
scanner  and other  instruments  to process  the probe  arrays and  software  to
analyze and manage genetic information. Additional information on Affymetrix and
GeneChip technology can be found at www.affymetrix.com.


                                     Page 1

<PAGE>


All statements in this press release that are not historical are forward-looking
statements  within the meaning of Section 21E of the  Securities  Exchange  Act,
including statements regarding the Company's "expectations," "beliefs," "hopes,"
"intentions," "strategies" or the like. Such statements are subject to risks and
uncertainties   that  could  cause  actual  results  to  differ  materially  for
Affymetrix from those projected,  including,  but not limited to,  uncertainties
relating to technological approaches,  product development,  manufacturing,  and
market  acceptance,  uncertainties  related to cost and  pricing  of  Affymetrix
products,  dependence on collaborative partners,  uncertainties relating to sole
source suppliers,  uncertainties relating to FDA and other regulatory approvals,
competition,   risks  relating  to  intellectual  property  of  others  and  the
uncertainties of patent protection and litigation.  These and other risk factors
are  discussed  in  Affymetrix'  Annual  Report on Form 10-K for the year  ended
December  31,  1998 and 10-Q for the  quarter  ended June 30,  1999 and Form S-3
filed July 12, 1999, as amended.  Affymetrix  expressly disclaims any obligation
or   undertaking   to  release   publicly   any  updates  or  revisions  to  any
forward-looking statements contained herein to reflect any change in Affymetrix'
expectations  with  regard  thereto  or any  change in  events,  conditions,  or
circumstances on which any such statements are based.  Affymetrix,  GeneChip and
the Affymetrix logo are registered trademarks used by Affymetrix, Inc.


                                     Page 2




FOR IMMEDIATE RELEASE

Contact:       Affymetrix, Inc.
               ----------------
               Edward M. Hurwitz             Anne Bowdidge
               Vice President and            Associate Director
               Chief Financial Officer       of Investor Relations
               (408) 731-5000                (408) 731-5925


               AFFYMETRIX, INC. RAISES $125 MILLION IN CONVERTIBLE
                          SUBORDINATED DEBT PLACEMENT


SANTA CLARA, CA -SEPTEMBER 17, 1999- Affymetrix,  Inc., (NASDAQ: AFFX) announced
today the private  placement of $125 million  principal amount of 5% Convertible
Subordinated Notes due 2006. The Notes are convertible, subject to adjustment in
certain circumstances,  into Affymetrix common stock at a price equal to $123.00
per share.

Affymetrix  has agreed to file a  registration  statement  for the resale of the
Notes and the shares of common stock  issuable upon the  conversion of the Notes
within 90 days after the closing date.  This summary of the terms and conditions
of the  Notes  is not  intended  to be a  complete  summary  of  the  terms  and
conditions of such securities. Copies of the Notes and related documents will be
filed with SEC on a form 8-K after the closing date.

The Notes have not been registered under the Securities Act of 1933, as amended,
or  applicable  state  securities  laws,  and unless so  registered,  may not be
offered or sold in the United States, except pursuant to an applicable exemption
from the  registration  requirements  of the Securities Act of 1933, as amended,
and applicable state securities laws.

This press release shall not constitute an offer to sell or the  solicitation of
an offer to buy the Notes. This press release is being issued pursuant to and in
accordance with Rule 135c under the Securities Act of 1933, as amended.

Affymetrix has developed and intends to establish its GeneChip(R)  system as the
platform  of choice  for  acquiring,  analyzing  and  managing  complex  genetic
information  in order to improve the  diagnosis,  monitoring  and  treatment  of
disease.  The Company's  GeneChip system consists of disposable DNA probe arrays
containing gene sequences on a chip,  reagents for use with the probe arrays,  a
scanner  and other  instruments  to process  the probe  arrays and  software  to
analyze and manage genetic information. Additional


                                     Page 1


<PAGE>

information on Affymetrix and GeneChip technology can be found at
www.affymetrix.com.


All statements in this press release that are not historical are forward-looking
statements  within the meaning of Section 21E of the Securities  Exchange Act as
amended, including statements regarding the Company's "expectations," "beliefs,"
"hopes," "intentions,"  "strategies" or the like. Such statements are subject to
risks and uncertainties that could cause actual results to differ materially for
Affymetrix from those projected,  including,  but not limited to,  uncertainties
relating to technological approaches,  product development,  manufacturing,  and
market  acceptance,  uncertainties  related to cost and  pricing  of  Affymetrix
products,  dependence on collaborative partners,  uncertainties relating to sole
source suppliers,  uncertainties relating to FDA and other regulatory approvals,
competition,   risks  relating  to  intellectual  property  of  others  and  the
uncertainties of patent protection and litigation.  These and other risk factors
are  discussed  in  Affymetrix'  Annual  Report on Form 10-K for the year  ended
December  31,  1998 and 10-Q for the  quarter  ended June 30,  1999 and Form S-3
filed July 12, 1999, as amended.  Affymetrix  expressly disclaims any obligation
or   undertaking   to  release   publicly   any  updates  or  revisions  to  any
forward-looking statements contained herein to reflect any change in Affymetrix'
expectations  with  regard  thereto  or any  change in  events,  conditions,  or
circumstances on which any such statements are based.  Affymetrix,  GeneChip and
the Affymetrix logo are registered trademarks used by Affymetrix, Inc.









                                     Page 2



FOR IMMEDIATE RELEASE

Contact:       Affymetrix, Inc.
               ----------------
               Edward M. Hurwitz             Anne Bowdidge
               Vice President and            Associate Director
               Chief Financial Officer       of Investor Relations
               (408) 731-5000                (408) 731-5925


                  AFFYMETRIX, INC. ANNOUNCES EXERCISE OF OPTION


SANTA CLARA, CA -SEPTEMBER 17, 1999- Affymetrix,  Inc., (NASDAQ: AFFX) announced
today that the initial purchaser of its recently  completed private placement of
$125 million principal amount of 5% Convertible  Subordinated Notes due 2006 has
exercised its option and purchased an additional $25 million of Notes. The Notes
are  convertible  into  Affymetrix  Common Stock at a price equal to $123.00 per
share.  Gross proceeds from the offering,  including exercise of the option, are
$150 million.

Affymetrix  has agreed to file a  registration  statement  for the resale of the
Notes and the shares of common stock  issuable upon the  conversion of the Notes
within 90 days after the closing date.  This summary of the terms and conditions
of the  Notes  is not  intended  to be a  complete  summary  of  the  terms  and
conditions of such securities. Copies of the Notes and related documents will be
filed with SEC on a form 8-K after the closing date.

The Notes have not been registered under the Securities Act of 1933, as amended,
or  applicable  state  securities  laws,  and unless so  registered,  may not be
offered or sold in the United States, except pursuant to an applicable exemption
from the  registration  requirements  of the Securities Act of 1933, as amended,
and applicable state securities laws.

This press release shall not constitute an offer to sell or the  solicitation of
an offer to buy the Notes. This press release is being issued pursuant to and in
accordance with Rule 135c under the Securities Act of 1933, as amended.

Affymetrix has developed and intends to establish its GeneChip(R)  system as the
platform  of choice  for  acquiring,  analyzing  and  managing  complex  genetic
information  in order to improve the  diagnosis,  monitoring  and  treatment  of
disease.  The Company's  GeneChip system consists of disposable DNA probe arrays
containing gene sequences on a chip,  reagents for use with the probe arrays,  a
scanner  and other  instruments  to process  the probe  arrays and  software  to
analyze and manage genetic information. Additional


                                     Page 1
<PAGE>

information   on   Affymetrix   and   GeneChip   technology   can  be  found  at
www.affymetrix.com.

All statements in this press release that are not historical are forward-looking
statements  within the meaning of Section 21E of the Securities  Exchange Act as
amended, including statements regarding the Company's "expectations," "beliefs,"
"hopes," "intentions,"  "strategies" or the like. Such statements are subject to
risks and uncertainties that could cause actual results to differ materially for
Affymetrix from those projected,  including,  but not limited to,  uncertainties
relating to technological approaches,  product development,  manufacturing,  and
market  acceptance,  uncertainties  related to cost and  pricing  of  Affymetrix
products,  dependence on collaborative partners,  uncertainties relating to sole
source suppliers,  uncertainties relating to FDA and other regulatory approvals,
competition,   risks  relating  to  intellectual  property  of  others  and  the
uncertainties of patent protection and litigation.  These and other risk factors
are  discussed  in  Affymetrix'  Annual  Report on Form 10-K for the year  ended
December  31,  1998 and 10-Q for the  quarter  ended June 30,  1999 and Form S-3
filed July 12, 1999, as amended.  Affymetrix  expressly disclaims any obligation
or   undertaking   to  release   publicly   any  updates  or  revisions  to  any
forward-looking statements contained herein to reflect any change in Affymetrix'
expectations  with  regard  thereto  or any  change in  events,  conditions,  or
circumstances on which any such statements are based.  Affymetrix,  GeneChip and
the Affymetrix logo are registered trademarks used by Affymetrix, Inc.






                                     Page 2



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