AFFYMETRIX INC
10-Q, 1999-05-17
COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH
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<PAGE>


                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                    FORM 10-Q

    X    Quarterly Report Pursuant to Section 13 or 15(d) of the Securities 
- -------- Exchange Act of 1934 for the period ended MARCH 31, 1999

                                       or

         Transition Report Pursuant to Section 13 or 15(d) of the Securities 
- -------- Exchange Act of 1934 for the transition period from        to        .
                                                            -------     ------


                           Commission File No. 0-28218

                                AFFYMETRIX, INC.
             (Exact name of Registrant as specified in its charter)

                     DELAWARE                              77-0319159

         (State or other jurisdiction of                (I.R.S. Employer
         incorporation or organization)               Identification Number)

         3380 CENTRAL EXPRESSWAY, SANTA CLARA, CALIFORNIA             95051
         (Address of principal executive offices)                   (Zip Code)

        Registrant's telephone number, including area code: (408)731-5000

         Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.

                                 Yes  X   No
                                     ----    ----


             COMMON SHARES OUTSTANDING ON MARCH 31, 1999: 24,159,333

<PAGE>

                                AFFYMETRIX, INC.
                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
PART I.       FINANCIAL INFORMATION

                                                                                                     Page
<S>        <C>                                                                                       <C>
Item 1.    Financial Statements
                Condensed Consolidated Balance Sheets at March 31, 1999
                     and December 31, 1998 ....................................................       3

                Condensed Consolidated Statements of Operations for the Three Months
                     Ended March 31, 1999 and 1998 ............................................       4


                Condensed Consolidated Statements of Cash Flows for the Three Months
                     Ended March 31, 1999 and 1998 ............................................       5

                Notes to Condensed Consolidated Financial Statements...........................       6


Item 2.    Management's Discussion and Analysis of Financial Condition and
                     Results of Operations ....................................................       8


Item 3.    Quantitative and Qualitative Disclosures About Market Risk..........................      11


PART II.      OTHER INFORMATION

Item 1.    Legal Proceedings...................................................................      12

Item 6.    Exhibits and Reports on Form 8-K ...................................................      14


SIGNATURES.....................................................................................      15
</TABLE>

                                       2

<PAGE>



PART 1.  FINANCIAL INFORMATION

ITEM 1.  FINANCIAL STATEMENTS

                                                  AFFYMETRIX, INC.
                                        CONDENSED CONSOLIDATED BALANCE SHEET

                                                   (In thousands)


<TABLE>
<CAPTION>
                                                                         March 31,                       December 31,
                                                                            1999                             1998
                                                                        ------------                     ------------
                                                                        (Unaudited)
<S>                                                                  <C>                              <C>
ASSETS

Current Assets:

      Cash and cash equivalents                                      $       29,761                   $        1,301
      Short-term investments                                                 70,164                           79,267
      Accounts receivable                                                    11,432                            8,919
      Inventories                                                             4,425                            3,276
      Other current assets                                                    1,605                            2,184
                                                                        ------------                     ------------
             Total current assets                                           117,387                           94,947

Net property and equipment                                                   33,008                           30,865

Acquired technology rights                                                    9,460                            9,625

Other assets                                                                  1,200                              991
                                                                        ------------                     ------------
                                                                     $      161,055                   $      136,428
                                                                        ------------                     ------------
                                                                        ------------                     ------------

LIABILITIES AND STOCKHOLDERS' EQUITY

Current liabilities                                                  $       13,441                  $        14,560

Obligation to Beckman Coulter, Inc.                                           5,000                            5,000

Other liabilities                                                               200                              261

Convertible redeemable preferred stock                                       49,857                           49,857

Stockholders' equity:

      Common stock                                                              242                              230
      Additional paid-in-capital                                            192,291                          159,147
      Accumulated deficit                                                   (99,797)                        (92,720)
      Other                                                                   (179)                               93
                                                                        ------------                    -------------
             Total stockholders' equity                                      92,557                           66,750
                                                                        ------------                    -------------
                                                                     $      161,055                  $       136,428
                                                                        ------------                     ------------
                                                                        ------------                     ------------
</TABLE>

Note:    The balance sheet at December 31, 1998 has been derived from the
         audited financial statements at that date but does not include all of
         the information and footnotes required by generally accepted accounting
         principles for complete financial statements.

                                               See accompanying notes.


                                       3

<PAGE>



                                AFFYMETRIX, INC.
              CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                   (In thousands, except per share amounts)
                                 (Unaudited)

<TABLE>
<CAPTION>
                                                                              Three Months Ended
                                                                                    March 31,
                                                                     1999                            1998
                                                               ------------------               ----------------
<S>                                                         <C>                              <C>
Revenue:

      Product                                               $             15,163             $            6,531
      Research                                                             2,444                          2,997
      License fees and royalties                                             197                            225
                                                               ------------------               ----------------
         Total revenue                                                    17,804                          9,753

Costs and expenses:

      Cost of product revenue                                              5,093                          2,493
      Research and development                                            10,367                          8,511
      Selling, general and administrative                                  9,658                          5,741
                                                               ------------------               ----------------
         Total costs and expenses                                         25,118                         16,745
                                                               ------------------               ----------------

Loss from operations                                                     (7,314)                         (6,992)

Interest income, net                                                       1,050                          1,092
                                                               ------------------               ----------------

Net loss                                                                 (6,264)                         (5,900)

Preferred stock dividends                                                  (813)                              -
                                                               ------------------               ----------------

Net loss attributable to
      Common Stockholders                                   $            (7,077)             $           (5,900)
                                                               ------------------               ----------------
                                                               ------------------               ----------------
Basic and diluted net loss
      per common share                                      $             (0.30)             $           (0.26)
                                                               ------------------               ----------------
                                                               ------------------               ----------------
</TABLE>


Note:  Certain prior year balances have been reclassified to conform with the
       current year presentation.

                                       See accompanying notes.

                                       4

<PAGE>



                                AFFYMETRIX, INC.
                 CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                Increase (decrease) in cash and cash equivalents
                                 (In thousands)
                                   (Unaudited)
<TABLE>
                                                                                                Three months ended March 31,
                                                                                            -------------------------------------
                                                                                                 1999                   1998
                                                                                            --------------          -------------
<S>                                                                                         <C>                     <C>
Cash flows from operating activities:
       Net loss                                                                                $   (6,264)             $  (5,900)
       Adjustments to reconcile net loss to net cash used in operating activities:
            Depreciation and amortization                                                           2,162                  1,069
            Change in operating assets and liabilities:
                 Accounts receivable                                                               (2,513)                 1,138
                 Inventories                                                                       (1,149)                  (547)
                 Other current assets                                                                 579                   (105)
                 Other assets                                                                        (209)                     4
                 Accounts payable and other accrued liabilities                                    (3,073)                (1,347)
                 Deferred revenue                                                                   1,140                    978
                                                                                            --------------          -------------
                       Net cash used in operating activities                                       (9,327)                (4,710)

Cash flows from investing activities:

       Capital expenditures                                                                        (3,713)                (4,548)
       Proceeds from the sale of short-term investments                                            18,419                 25,309
       Proceeds from maturities of short-term investments                                               -                    (34)
       Purchases of short-term investments                                                        (10,015)               (19,496)
                                                                                            --------------          -------------
                       Net cash provided by investing activities                                    4,691                  1,231

Cash flows from financing activities:

       Issuance of common stock                                                                    33,156                    253
       Principal payments on capital lease obligation                                                 (60)                   (55)
                                                                                            --------------          -------------
                       Net cash provided by financing activities                                   33,096                    198

Net increase / (decrease) in cash and cash equivalents                                             28,460                 (3,281)
Cash and cash equivalents at beginning of period                                                    1,301                  4,779
                                                                                            --------------          -------------
Cash and cash equivalents at end of period                                                     $   29,761              $   1,498
                                                                                            --------------          -------------
                                                                                            --------------          -------------
</TABLE>
                          See accompanying notes.


                                       5

<PAGE>





                                 AFFYMETRIX, INC.
               NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS
                                  MARCH 31, 1999
                                   (Unaudited)

NOTE 1--SUMMARY OF SIGNIFICANT ACCOUNTING PRINCIPLES

    BASIS OF PRESENTATION

         The accompanying unaudited condensed consolidated financial 
statements have been prepared in accordance with generally accepted 
accounting principles for interim financial information and with the 
instructions to Form 10-Q and Article 10 of Regulation S-X. Accordingly, they 
do not include all of the information and footnotes required by generally 
accepted accounting principles for complete financial statements. The 
consolidated financial statements include accounts of Affymetrix, Inc. 
("Affymetrix" or the "Company") and Affymetrix, UK Ltd., a wholly owned 
subsidiary functioning as a sales and technical arm for the European market. 
All material intercompany accounts and transactions have been eliminated in 
consolidation. In the opinion of management, all adjustments (consisting of 
normal recurring entries) considered necessary for a fair presentation have 
been included. Operating results for the three months ended March 31, 1999 
are not necessarily indicative of the results that may be expected for the 
year ending December 31, 1999. For further information, refer to the 
financial statements and notes thereto included in the Annual Report on Form 
10-K for the year ended December 31, 1998 filed by Affymetrix. Certain 
amounts in 1998 have been reclassified to conform to 1999 presentation.

    REVENUE RECOGNITION

         Product revenues include sales of GeneChip-Registered Trademark- 
instrumentation, software and probe arrays as well as the associated 
subscription fees earned under EasyAccess-TM- supply agreements. 
Instrumentation, software and probe array revenues are generally recognized 
upon shipment. Reserves are provided for anticipated returns and warranty 
expenses at the time the associated revenue is recognized. Revenues from 
subscription fees earned under EasyAccess supply agreements are recorded 
ratably over the term of the agreement subject to adjustments for anticipated 
reductions provided for in certain agreements for late delivery of probe 
arrays. Payments received in advance under these arrangements are recorded as 
deferred revenue until earned. Research revenues include amounts earned, 
including milestones, from services performed pursuant to commercial 
collaboration and supply agreements as well as under government grants. 
Research revenues are recorded in the period in which the costs are incurred 
or in which the revenues are earned as defined in the related agreement. 
Direct costs associated with these contracts and grants are reported as 
research and development expense. License and royalty revenues include 
amounts earned from third parties licensed under the Company's intellectual 
property and are recognized when earned under the terms of the related 
agreements.

NOTE 2--CASH, CASH EQUIVALENTS AND SHORT-TERM INVESTMENTS

         As of March 31, 1999, debt securities held by the Company are 
comprised of U.S. Government obligations and U.S. corporate debt securities. 
They are classified as available-for-sale and are carried at fair value with 
unrealized gains and losses reported in stockholders' equity.

                                       6

<PAGE>

NOTE 3--INVENTORIES

         Inventories consist of the following (in thousands):

<TABLE>
<CAPTION>
                                                            March 31,         December 31,
                                                              1999                1998
                                                           -----------        -------------
<S>                                                        <C>                <C>
Raw material...........................................     $   2,070              $  1,775
Work in process........................................           189                    70
Finished goods.........................................         2,166                 1,431
                                                           -----------             --------
    Total..............................................     $   4,425              $  3,276
                                                           -----------             --------
                                                           -----------             --------
</TABLE>

NOTE 4--COMPREHENSIVE LOSS

         The components of comprehensive loss for the three months ended 
March 31, 1999 and 1998 are as follows (in thousands):

<TABLE>
<CAPTION>
                                                             Three Months Ended
                                                                 March 31,
                                                              1999       1998
                                                            ---------  ---------
<S>                                                         <C>        <C>
Net loss attributable to common stockholders.............    $(7,077)   $(5,900)
Unrealized gain (loss) on securities.....................       (335)        80
                                                            ---------  ---------
Comprehensive loss.......................................    $(7,412)   $(5,820)
                                                            ---------  ---------
                                                            ---------  ---------
</TABLE>

NOTE 5--COMMON STOCK PURCHASE AGREEMENT

         On March 15, 1999, the Company completed the private placement of 
1,000,000 shares of common stock for an aggregate purchase price of $32.5 
million to the Growth Fund of America, Inc., which is managed by Capital 
Research and Management Company. The Company is obligated to file a 
registration statement to cover all of these shares within 90 days of the 
completion of the private placement.

NOTE 6--FOREIGN CURRENCY TRANSLATION

         The financial statements of Affymetrix, UK Ltd. are measured using 
the U.S. dollar as the functional currency. Assets and liabilities of this 
subsidiary are translated at the rates of exchange at the balance sheet date. 
Income and expense items are translated at average quarterly rates of 
exchange. The resultant translation adjustments are included in the 
consolidated statement of operation.

                                       7

<PAGE>

Item 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL 
         CONDITION AND RESULTS OF OPERATIONS

         This Management's Discussion and Analysis of Financial Condition and 
Results of Operations as of March 31, 1999 and for the three month periods 
ended March 31, 1999 and 1998 should be read in conjunction with the 
Management's Discussion and Analysis of Financial Condition and Results of 
Operations included in the Company's Annual Report on Form 10-K for the year 
ended December 31, 1998.

         All statements in this discussion that are not historical are 
forward-looking statements. Such statements are subject to risks and 
uncertainties that could cause actual results to differ materially for 
Affymetrix from those projected, including, but not limited to, uncertainties 
relating to technological approaches, product development, manufacturing and 
market acceptance, uncertainties related to cost and pricing of Affymetrix' 
products, dependence on collaborative partners, uncertainties relating to 
sole source suppliers, uncertainties relating to FDA and other regulatory 
approvals, competition, risks relating to intellectual property of others and 
the uncertainties of patent protection. These and other risk factors are 
discussed in Affymetrix' Annual Report on Form 10-K for the year ended 
December 31, 1998. Affymetrix expressly disclaims any obligation or 
undertaking to release publicly any updates or revisions to any 
forward-looking statements contained herein to reflect any change in 
Affymetrix' expectations with regard thereto or any change in events, 
conditions, or circumstances on which any such statements are based.

OVERVIEW

         Affymetrix, Inc. has developed and intends to establish its GeneChip 
system as the platform of choice for acquiring, analyzing and managing 
complex genetic information in order to improve the diagnosis, monitoring and 
treatment of disease. The Company's GeneChip system consists of disposable 
DNA probe arrays containing gene sequences on a chip, reagents for use with 
the probe arrays, a scanner and other instruments to process the probe 
arrays, and software to analyze and manage genetic information.

         The business and operations of the Company were commenced in 1991 by 
Affymax N.V. ("Affymax") and were initially conducted within Affymax. In 
March 1992, the Company was incorporated as a California corporation and 
wholly owned subsidiary of Affymax and in September 1998 was reincorporated 
as a Delaware corporation. In March 1995, Glaxo plc, now Glaxo Wellcome plc 
("Glaxo"), acquired Affymax, including its ownership interest in Affymetrix. 
Beginning in September 1993, the Company issued equity securities which 
diluted Affymax' and then Glaxo's ownership in Affymetrix. On April 14, 1998, 
the Company completed the sale of 1,634,522 shares of Series AA Preferred 
Stock to Glaxo Wellcome Americas, Inc. (a wholly owned subsidiary of Glaxo) 
for net proceeds of approximately $49.9 million. The Preferred Stock is 
convertible into Affymetrix Common Stock at approximately $40.00 per share. 
Glaxo's acquisition of the Series AA Preferred Stock increased Glaxo's 
beneficial ownership of Affymetrix to approximately 37% on an as converted 
basis. In March 1999, the Company sold 1,000,000 shares of common stock to a 
third party in a private placement, which reduced Glaxo's ownership position 
to 35% on an as converted basis.

                                       8

<PAGE>

RESULTS OF OPERATIONS

     THREE MONTHS ENDED MARCH 31, 1999 AND 1998

         Product revenue increased 132% to $15.2 million for the quarter 
ended March 31, 1999, up from $6.5 million for the quarter ended March 31, 
1998. The increase in product revenue during the quarter, compared to the 
same period in 1998, resulted principally from the growth in placements of 
GeneChip-Registered Trademark- systems together with the accompanying sales 
of GeneChip probe arrays and related products and subscription fees. Research 
revenue decreased 18% to $2.4 million for the quarter ended March 31, 1999, 
down from $3.0 million for the quarter ended March 31, 1998. The decrease was 
due principally to the timing of milestone achievements under research 
contracts, offset by higher grant revenue from the Advanced Technology 
Program, for which the funding expires in January 2000. License fees and 
royalties revenue was $0.2 million in both the three months ended March 31, 
1999 and 1998.

         Cost of product revenue was $5.1 million for the three months ended 
March 31, 1999, compared to $2.5 million for the three months ended March 31, 
1998. Gross margin on product revenue was approximately 66% for the three 
months ended March 31, 1999, compared to 62% for the three months ended March 
31, 1998. The improved gross margin was principally the result of higher 
subscription fees recorded for the three months ended March 31, 1999. The 
Company currently expects that gross margins will decline for the remainder 
of 1999 as costs associated with the expansion of manufacturing capacity at 
the Company's Sunnyvale and West Sacramento facilities are incurred. Margins 
have fluctuated, and will continue to fluctuate significantly, as a result of 
variations in manufacturing yields and changes in the mix of products sold. 
In addition, the Company has experienced, and continues to experience, 
variations in the manufacturing yield of its GeneChip products which has 
impacted, and will continue to impact, the Company's ability to meet its 
commitments to deliver product to its customers in a timely manner. Any 
prolonged difficulty in providing timely delivery of products may adversely 
affect the Company's relationships with its customers and its business, its 
financial condition and results of operations.

         Research and development expenses were $10.4 million for the three 
months ended March 31, 1999, compared to $8.5 million for the three months 
ended March 31, 1998. The increase in research and development expenses was 
attributable primarily to the hiring of additional research and development 
personnel and associated purchases of research supplies. The Company expects 
research and development spending to increase over the next several years as 
product development and core research efforts continue to expand.

         Selling, general and administrative expenses were $9.7 million for 
the three months ended March 31, 1999, compared to $5.7 million for the three 
months ended March 31, 1998. The increase in selling, general and 
administrative expenses resulted primarily from the Company's expansion of 
commercial activities and significantly increased legal costs arising from 
the Company's ongoing patent litigation. Selling, general and administrative 
expenses are expected to continue to increase as the Company expands sales 
and marketing, prosecutes and defends its intellectual property position and 
defends against claims made by third parties, and adds management and support 
staff. In particular, the Company expects legal costs to increase over the 
next several months as ongoing patent litigation with Hyseq, Inc. and with 
Incyte Pharmaceuticals, Inc. and Synteni, Inc. result in increased additional 
legal expenditures.

                                       9

<PAGE>

         Net interest income was $1.0 million for the three months ended 
March 31, 1999, compared to $1.1 million for the three months ended March 31, 
1998. The fluctuations in net interest income result principally from 
variation in the Company's short-term investment balances.

     IMPACT OF YEAR 2000

         The Company is assessing the potential impact of the Year 2000 
computer problem on its products (including GeneChip systems and software), 
information systems, embedded systems (including computers used in its 
manufacturing process) and on the ability of certain third parties to supply 
critical materials and services as well as the readiness of certain 
customers. The Company has initiated the assessment of its products, 
identified certain software code that needs to be revised and is in the 
process of updating this code for existing and future products. The Company 
believes that with this update, its products will be Year 2000 ready. The 
Company expects to complete the assessment of its computer systems, embedded 
systems, certain third party suppliers and major customers by the end of the 
second quarter of 1999, and to take necessary remediation action by the end 
of 1999. Expenditures to date have not been material and have consisted 
solely of the limited use of outside consultants and the time of certain 
company personnel. Based on the partial assessment completed through March 
31, 1999, the Company does not currently expect the future costs of 
completing the assessment, modifying its products, making system 
modifications, purchasing replacement computer systems and assessing the Year 
2000 readiness of material third party suppliers and major customers to be 
material. While the Company does not anticipate a material business 
interruption to result from the Year 2000 problem, the Company gives no 
assurances that its products or systems will be Year 2000 ready and the 
Company cannot guarantee the Year 2000 readiness of key third party suppliers 
and service providers, collaborators and major customers. Pending the 
completion of the assessment of the Company's Year 2000 readiness, the 
Company may make certain contingency plans (for example the stockpile of 
critical raw materials in late 1999), but currently such plans have not been 
developed. If any of the Company's products or information systems, embedded 
systems, key third party suppliers and services providers and major customers 
are not Year 2000 ready, the Company may experience a business interruption 
and be subject to certain litigation which would have a material adverse 
impact on the Company's business, results of operations and financial 
condition.

LIQUIDITY AND CAPITAL RESOURCES

         As of March 31, 1999, the Company's cash, cash equivalents, and 
short-term investments were $99.9 million compared to $80.6 million at 
December 31, 1998. The increase is primarily attributable to the proceeds 
from issuance of common stock to Growth Fund of America, Inc., offset by cash 
used to fund the Company's operating loss and capital expenditures, 
principally for the expansion of manufacturing capacity.

         Net cash used in operating activities was $9.3 million for the three 
months ended March 31, 1999, as compared to $4.7 million for the three months 
ended March 31, 1998. The increase in net cash used in operating activities 
resulted primarily from increases in the Company's net loss and changes in 
operating assets and liabilities.

         The Company's investing activities, other than purchases, sales and
maturities of available-for-sale securities, consisted of capital expenditures,
which totaled $3.7 million for the three months ended March 31, 1999 and $4.5
million for the three months ended March 31, 1998. Capital expenditures during
the three months ended March 31, 1999 primarily included 

                                       10

<PAGE>

facilities and production equipment for the new manufacturing facility in 
West Sacramento, California. The Company expects to increase its capital 
expenditures during the remainder of 1999 to further complete and expand the 
West Sacramento manufacturing facility.

         Financing activities for the three months ended March 31, 1999, 
include net proceeds of $32.5 million from the private placement of 1,000,000 
shares of common stock in March 1999.

         The Company anticipates that its existing capital resources will 
enable it to maintain currently planned operations and planned capital 
expenditures through at least 2000. However, this expectation is based on the 
Company's current operating plan and capital expenditure plan, which could 
change, and therefore the Company could require additional funding sooner 
than anticipated. In addition, the Company expects its capital requirements 
to increase over the next several years as it expands its facilities and 
acquires scientific equipment to support expanded manufacturing and research 
and development efforts. The Company's long-term capital expenditure 
requirements will depend on numerous factors, including, but not limited to: 
the progress of its research and development programs; initiation or 
expansion of research programs; the development of commercial scale 
manufacturing capabilities; its ability to maintain existing collaborative 
and customer arrangements and establish and maintain new collaborative and 
customer arrangements; the costs involved in preparing, filing, prosecuting, 
defending and enforcing intellectual property rights; the effectiveness of 
products; commercialization activities and arrangements; and other factors.

ITEM 3.  QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET
              RISK

         There have been no material changes in the Company's reported risk 
since December 31, 1998.

                                       11
<PAGE>



PART II.  OTHER INFORMATION

ITEM 1.  LEGAL PROCEEDINGS

         On March 3, 1997, Hyseq filed a lawsuit in United States District 
Court for the Northern District of California (San Jose Division) alleging 
that Affymetrix' products infringe United States Patents 5,202,231 and 
5,525,464. In addition, in December 1997, Hyseq filed a second action 
claiming that Affymetrix' products infringe a related patent, United States 
Patent 5,695,940. On August 18, 1998, the Company filed a lawsuit in Federal 
District Court in the Northern District of California (San Francisco 
Division) against Hyseq alleging infringement of U.S. Patent Nos. 5,795,716 
and 5,744,305 ("'305"). On September 1, 1998, the Company added Affymetrix' 
U.S. Patent No. 5,800,992 ("'992") to the complaint of infringement against 
Hyseq. The Hyseq action, which seeks damages based on the sale of Affymetrix' 
products and processes and seeks to enjoin commercial activities relating to 
those products and processes, and any other legal action against the Company 
or its collaborative partners claiming damages on account of the sale of 
Affymetrix' products and seeking to enjoin commercial activities relating to 
the affected products and processes could, in addition to subjecting the 
Company to potential liability for damages, require the Company or its 
collaborative partners to obtain a license in order to continue to 
manufacture or market the affected products and processes. While the Company 
believes that the Hyseq complaints are without merit, there can be no 
assurance that the Company will prevail in the Hyseq actions or that the 
Company or its collaborative partners will prevail in any other action, nor 
can there be any assurance that any license required would be made available 
on commercially acceptable terms, if at all. Furthermore, the Company has 
incurred and is likely to continue to incur substantial costs and expend 
substantial personnel time in defending against the claims filed by Hyseq.

         On January 6, 1998, the Company filed a patent infringement action 
in the United States District Court for the District of Delaware (No. 98-6) 
alleging that certain of Incyte's and Synteni's products infringe United 
States Patent 5,445,934 ("'934"). On September 1, 1998, the Company filed a 
complaint against Incyte and Synteni in Federal District Court in Delaware 
alleging infringement of the '305 Patent and the '992 Patent. These actions 
were transferred to the United States District Court for the Northern 
District of California on November 18, 1998, as case numbers C98-4507 and 
C98-4508, respectively. The actions seek to enjoin commercial activities of 
Incyte and Synteni relating to the Affymetrix patents and, in regard to the 
'992 Patent, sought a preliminary injunction. Incyte and Synteni moved for 
summary judgement that certain claims of the `992 Patent were invalid. On May 
4, 1999, the Court denied Affymetrix' motion for preliminary injunction and 
denied Incyte/Synteni's motion for summary judgement.

         There can be no assurance that Affymetrix will prevail in asserting 
its patent rights against Hyseq, Incyte, Synteni or others. The Company has 
and is likely to continue to incur substantial costs and expend substantial 
personnel time in asserting the Company's patent rights against Hyseq, 
Incyte, Synteni and others. Failure to successfully enforce its patent rights 
or the loss of these patent rights or others would remove a legal obstacle to 
competitors in designing probe array systems with similar competitive 
advantages to the GeneChip technology, which could have a material adverse 
effect on the Company's business, financial condition and operating results.

         The United States Patent and Trademark Office ("USPTO") notified 
Affymetrix that Stanford University presented claims that relate to 
substantially the same subject matter as certain claims from the `992 Patent 
and all of the claims of the `305 Patent. The Stanford application is alleged 
to be exclusively licensed to Incyte. The USPTO notified Affymetrix on April 
2, 1999 that it had declared an interference proceeding relating to these 
patents and claims of patents. The 

                                       12

<PAGE>

USPTO will conduct proceedings to determine the priority of these claims. 
These proceedings will result in substantial costs to the Company. Affymetrix 
cannot assure that it will prevail in such proceedings. Failure to prevail 
could result in inability to prevent others from copying aspects of 
Affymetrix' products and/or adversely affect our own freedom to operate, and 
could have a material adverse effect on the Company's business, financial 
condition, and results of operation.

         On April 17, 1998, Incyte filed a response and counterclaim to case 
number C98-4507, asserting the '934 Patent is invalid and not infringed. 
Also, on April 17, 1998, Incyte filed a counterclaim alleging that a patent 
license agreement entered into in December 1997 between Affymetrix and 
Molecular Dynamics interfered with an agreement between Incyte and Molecular 
Dynamics. In the counterclaim, Incyte alleges that the terms of the patent 
license to Molecular Dynamics prevented Molecular Dynamics from meeting its 
obligations to Incyte and seeks damages from Affymetrix. On September 21, 
1998, Incyte and Synteni filed an answer asserting various defenses to the 
lawsuits in relation to the '992 Patent and the '305 Patent, and asserted 
several counterclaims, namely a request for declaration of noninfringement 
and invalidity, an assertion of unfair competition, a request for a 
declaration that Synteni and Dari Shalon (a one time employee of Synteni) 
have not misappropriated any of Affymetrix' trade secrets, a claim of 
tortious interference with Incyte's and Synteni's economic advantage, a claim 
of slander of title of a patent and a claim of trade libel. Affymetrix 
believes the counterclaims are without merit. However, the Company has and is 
likely to continue to incur substantial costs and expend substantial 
personnel time in defending against these and any other counterclaims filed 
by Incyte and Synteni. Failure to successfully enforce its patent rights or 
defend against counterclaims of Incyte, Synteni, or others could have a 
material adverse effect on the Company's business, financial condition and 
operating results.

                                       13

<PAGE>

ITEM 6.    EXHIBITS AND REPORTS ON FORM 8-K

(a)  Exhibits:

<TABLE>
<CAPTION>
      EXHIBIT
      NUMBER                             DESCRIPTION OF DOCUMENT
      -------                            -----------------------
<S>                        <C>
      (1) 3.1              Certificate of Incorporation

      (1) 3.2              Bylaws

       + 10.41             Promissory Note between Rich Rava and the Company 
                           dated April 3, 1997.

            27             Financial data schedule.
</TABLE>

- ----------
(1)  Incorporated by reference to the same number exhibit filed with 
     Registrant's Form 8-K as filed on September 29, 1998 (File No. 
     000-28218).

+    Management contract, compensatory plan or arrangement.

(b)  Reports on Form 8-K.

         No reports on Form 8-K were filed during the quarter ended March 31,
1999.


                                       14

<PAGE>

                                   SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934, 
the Registrant has duly caused this report to be signed on its behalf by the 
undersigned, thereunto duly authorized.

May 13, 1999                                    AFFYMETRIX, INC.

                                                By:   /s/ Edward M. Hurwitz    
                                                     --------------------------
                                                      Edward M. Hurwitz
                                                      Vice President and
                                                      Chief Financial Officer

                                       15


<PAGE>



                                                  AFFYMETRIX, INC.
                                                    EXHIBIT INDEX

                                                   March 31, 1999

<TABLE>
<CAPTION>
     EXHIBIT
     NUMBER                                    DESCRIPTION OF DOCUMENT
     -------                                   -----------------------
<S>                        <C>
      (1) 3.1              Certificate of Incorporation

      (1) 3.2              Bylaws

       + 10.41             Promissory Note between Rich Rava and the Company 
                           dated April 3, 1997.

            27             Financial data schedule.
</TABLE>

- ----------
(1)  Incorporated by reference to the same number exhibit filed with 
     Registrant's Form 8-K as filed on September 29, 1998 (File No. 
     000-28218).

+    Management contract, compensatory plan or arrangement.



                                       16


<PAGE>

                                 PROMISSORY NOTE

Santa Clara, California                                         $50,000.00

April 3, 1997

1.   FOR VALUE RECEIVED, the undersigned RICHARD RAVA ("Rava") 
     unconditionally promise to pay to the order of Affymetrix Inc. 
     ("Affymetrix") at 3380 Central Expressway, Santa Clara, California (or 
     at such other address as the holder of this Note may designate by notice 
     to Rava), the sum of Fifty Thousand Dollars ($50,000.00) with interest 
     from the date hereof at 6.49% simple interest per annum. Such interest 
     shall be forgiven so long as Rava shall remain an employee of Affymetrix 
     in good standing.
     
2.   This Note, including all outstanding principal and any interest due 
     hereon shall be paid in full five years from the date of this Note.

3.   This note shall become immediately due and payable in full prior to 
     maturity if any of the following occur: sale of the residence at 338 
     LAKEVIEW WAY, REDWOOD CITY, CA; (the "Residence"); if the Residence 
     shall cease to be the principal residence of Rava; if any payment is not 
     made when due; or upon termination of Rava's employment by Affymetrix 
     for any reason. Rava requests and authorizes Affymetrix to withhold any 
     amount due Affymetrix hereunder from any salary, proceed of sale of 
     Affymetrix stock, stock options or other compensation due or payable to 
     Rava.

4.   Rava agrees to pay all reasonable costs of collection of this Note 
     if payments are not made when due. If legal action is necessary to 
     enforce or collect this Note, such costs shall include, without 
     limitation, reasonable attorney's fees. Interest shall accrue on all 
     past due payments at the rate of 10% per annum or the highest rate 
     permitted by law if lower.
     

5.   This Note shall be governed by and construed in accordance with the 
     internal laws of the State of California. Rava consents to personal 
     jurisdiction in any court in Santa Clara County, California.


      /s/ Richard P. Rava                              4/3/97
     -----------------------                        -----------
           RICHARD RAVA                                   Date



Witness:  /s/  Kenneth J. Nussbacher
        ------------------------------
              KENNETH NUSSBACHER

<TABLE> <S> <C>

<PAGE>
<ARTICLE> 5
<LEGEND>
THIS SCHEDULE CONTAINS SUMMARY FINANCIAL INFORMATION EXTRACTED FROM ITEM 1 OF
THE COMPANY'S FORM 10-Q FOR THE PERIOD ENDED MARCH 31, 1999 AND IS QUALIFIED IN
ITS ENTIRETY BY REFERENCE TO SUCH FINANCIAL STATEMENTS.
</LEGEND>
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          DEC-31-1999
<PERIOD-START>                             JAN-01-1999
<PERIOD-END>                               MAR-31-1999
<CASH>                                          29,761
<SECURITIES>                                    70,164
<RECEIVABLES>                                   11,432
<ALLOWANCES>                                     (476)
<INVENTORY>                                      4,425
<CURRENT-ASSETS>                               117,387
<PP&E>                                          44,509
<DEPRECIATION>                                (11,501)
<TOTAL-ASSETS>                                 161,055
<CURRENT-LIABILITIES>                           13,441
<BONDS>                                            200
                           49,857
                                          0
<COMMON>                                           242
<OTHER-SE>                                      92,315
<TOTAL-LIABILITY-AND-EQUITY>                   161,055
<SALES>                                         15,163
<TOTAL-REVENUES>                                17,804
<CGS>                                            5,093
<TOTAL-COSTS>                                    5,093
<OTHER-EXPENSES>                                20,025
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                 237
<INCOME-PRETAX>                                (7,077)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                            (7,077)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   (7,077)
<EPS-PRIMARY>                                   (0.30)
<EPS-DILUTED>                                   (0.30)
        

</TABLE>


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