LYNX THERAPEUTICS INC
10-Q, 1997-08-11
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM 10-Q


     X       QUARTERLY  REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
- ---------    EXCHANGE ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED JUNE 30, 1997.

                                       OR

              TRANSITION   REPORT  PURSUANT  TO  SECTION  13  OR  15(d)  OF  THE
- ---------     SECURITIES  EXCHANGE  ACT OF 1934 FOR THE  TRANSITION  PERIOD FROM
                    TO       .
              ------   -----


                         Commission File Number 0-22570


                             Lynx Therapeutics, Inc.
             (Exact name of registrant as specified in its charter)


                Delaware                               94-3161073
      (State or other jurisdiction of               (I.R.S. Employer
     incorporation or organization)               Identification No.)


          3832 Bay Center Place
                 Hayward, CA                             94545
  (Address of principal executive offices)             (Zip Code)


                                 (510) 670-9300
              (Registrant's telephone number, including area code)


Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  Registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days.

                          Yes     X      No
                             -----------   -----------


The  number of  shares  of Common  Stock,  Series B  Preferred  Stock,  Series C
Preferred Stock,  and Series D Preferred Stock  outstanding as of July 31, 1997,
were:  3,207,670;  332,288;  123,299;  and 40,000,  respectively.  The Series B,
Series C and Series D Preferred  Stock are  convertible  into Common  Stock on a
ten-for-one  basis.  Information  regarding  the  aggregate  market value of the
Registrant's  voting  stock  is not  included  because  there  is  currently  no
established public trading market for the Company's voting stock.


                                                                    Page 1 of 11


<PAGE>


<TABLE>


                                              Lynx Therapeutics, Inc.



                                                       INDEX


<CAPTION>

PART I            FINANCIAL INFORMATION                                                                        Page
<S>               <C>                                                                                            <C>

Item 1.           Condensed Consolidated Balance Sheets - June 30, 1997
                      and December 31, 1996...............................................................        3

                  Condensed Consolidated Statements of Operations - three and six  months
                       ended June 30, 1997 and 1996.......................................................        4

                  Condensed Consolidated Statements of Cash Flows - six  months
                      ended June 30, 1997 and 1996........................................................        5

                  Notes to Condensed Consolidated Financial Statements....................................        6

Item 2.           Management's Discussion and Analysis of
                      Financial Condition and Results of Operations.......................................        7


PART II           OTHER INFORMATION

Item 1.           Legal Proceedings.......................................................................       10

Item 2.           Changes in Securities...................................................................       10

Item 3.           Defaults Upon Senior Securities.........................................................       10

Item 4.           Submission of Matters to a Vote of Security Holders.....................................       10

Item 5.           Other Information.......................................................................       10

Item 6.           Exhibits and Reports on Form 8-K........................................................       10

Signatures        ........................................................................................       11




                                                                                                       Page 2 of 11
</TABLE>
<PAGE>


PART I            FINANCIAL INFORMATION

Item 1.           Financial Statements
<TABLE>

                                              Lynx Therapeutics, Inc.
                                       CONDENSED CONSOLIDATED BALANCE SHEETS
                                                  (In thousands)
<CAPTION>

                                                                                June 30,            December 31,
                                                                                  1997                 1996*
                                                                       ---------------------------------------------
                                                                              (Unaudited)
<S>                                                                          <C>                       <C>

Assets
Current assets:
   Cash and cash equivalents                                                 $    6,718                $   12,109
   Short-term investments                                                            --                     1,973
   Accounts receivable                                                              191                       118
   Other current assets                                                              67                       158
                                                                       ---------------------------------------------
Total current assets                                                              6,976                    14,358

Property and equipment:
   Leasehold improvements                                                         3,749                     3,193
   Laboratory and other equipment                                                 3,663                     2,976
                                                                       ---------------------------------------------
                                                                                  7,412                     6,169
   Less accumulated depreciation and amortization                                (2,921)                   (2,290)
                                                                       ---------------------------------------------
Net property and equipment                                                        4,491                     3,879

Notes receivable from employees                                                     189                       175
                                                                       ---------------------------------------------
                                                                             $   11,656                $   18,412
                                                                       =============================================
Liabilities and stockholders' equity
Current liabilities:
   Accounts payable                                                          $      349                $      429
   Accrued compensation and vacation                                                311                       394
   Accrued professional fees                                                        107                       169
   Deferred revenue from related parties - current                                3,125                     3,875
   Other accrued liabilities                                                        365                       373
                                                                       ---------------------------------------------
Total current liabilities                                                         4,257                     5,240

Deferred revenue from related parties - long-term                                   916                     2,292
Other noncurrent liabilities                                                        164                       148

Stockholders' equity:
   Preferred stock                                                               27,189                    27,189
   Common stock                                                                  17,469                    17,361
   Notes receivable from stockholders                                              (460)                     (210)
   Deferred compensation                                                         (1,650)                   (2,092)
   Unrealized gain/(loss) on marketable securities                                   (2)                        3
   Accumulated deficit                                                          (36,227)                  (31,519)
                                                                       ---------------------------------------------
Total stockholders' equity                                                        6,319                    10,732
                                                                       ---------------------------------------------
                                                                             $   11,656                $   18,412
                                                                       =============================================
<FN>

*The Balance  Sheet  amounts at December 31, 1996 have been derived from audited
 financial statements at that date but do not include all of the information and
 footnotes  required by generally  accepted  accounting  principles for complete
 financial statements.



                                               See accompanying notes.
</FN>


                                                                                                        Page 3 of 11
</TABLE>

<PAGE>


<TABLE>

                                              Lynx Therapeutics, Inc.
                                  CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                                (In thousands, except share and per share amounts)
                                                    (Unaudited)


<CAPTION>
                                                           Three Months Ended                 Six Months Ended
                                                                June 30,                          June 30,
                                                    -------------------------------------------------------------------

                                                             1997            1996            1997           1996
                                                             ----            ----            ----           ----
<S>                                                     <C>             <C>             <C>            <C>

Net revenues:
   Revenues from collaborative arrangements
     with related parties                                   1,224             375           2,287            750
   Other revenues                                              98              87             170            204
                                                    -------------------------------------------------------------------
Total revenues                                              1,322             462           2,457            954

Operating  expenses:
   Research and development                                 3,377           2,929           6,452          5,334
   General and administrative                                 591             628           1,017          1,167
                                                    -------------------------------------------------------------------
Total operating  expenses                                   3,968           3,557           7,469          6,501
                                                    -------------------------------------------------------------------

Loss from operations                                       (2,646)         (3,095)         (5,012)        (5,547)

Interest income                                               133             143             304            330
                                                    -------------------------------------------------------------------
Net loss                                                   (2,513)         (2,952)         (4,708)        (5,217)
                                                    ===================================================================

Net loss per share                                          (0.79)          (1.26)          (1.49)         (2.23)
                                                    ===================================================================

Shares used in per share computation                    3,198,205       2,338,815       3,171,416      2,336,820
                                                    ===================================================================



<FN>

                                              See accompanying notes.
</FN>



                                                                                                           Page 4 of 11
</TABLE>
<PAGE>


<TABLE>

                                              Lynx Therapeutics, Inc.
                                  CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                                  (In thousands)
                                                    (Unaudited)


<CAPTION>

                                                                                             Six Months Ended
                                                                                                 June 30,
                                                                                   ---------------------------------
                                                                                             1997            1996
                                                                                             ----            ----
Cash flows from operating activities
<S>                                                                                     <C>              <C>

Net loss                                                                                $  (4,708)       $ (5,217)
Adjustments to reconcile net loss to net cash used in operating activities:
     Depreciation and amortization                                                            631             457
     Deferred compensation                                                                    293             ---
     Changes in operating assets and liabilities:
         Accounts receivable                                                                  (73)            (12)
         Other current assets                                                                  91            (145)
         Accounts payable                                                                     (80)            (65)
         Accrued liabilities                                                                 (153)            246
         Deferred revenue from related parties                                             (2,126)           (750)
         Other noncurrent liabilities                                                          16              29
                                                                                   ---------------------------------
Net cash used in operating activities                                                      (6,109)         (5,457)

Cash flows from investing activities
Purchases of short-term investments                                                            --            (995)
Maturities of short-term investments                                                        1,968             994
Purchases of property and equipment                                                        (1,243)         (1,006)
Notes receivable from employees                                                              (264)           (230)
                                                                                   ---------------------------------
Net cash provided by (used in) investing activities                                           461          (1,237)

Cash flows from financing activities
Issuance of common stock                                                                      257              13
                                                                                   ---------------------------------
Net cash provided by  financing activities                                                    257              13
                                                                                   ---------------------------------

Net decrease in cash and cash equivalents                                                  (5,391)         (6,681)
Cash and cash equivalents at beginning of period                                           12,109          13,779
                                                                                   ---------------------------------
Cash and cash equivalents at end of period                                              $   6,718        $  7,098
                                                                                   =================================



<FN>
                                              See accompanying notes.
</FN>

                                                                                                        Page 5 of 11
</TABLE>
<PAGE>


                             Lynx Therapeutics, Inc.
                   NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

                                  June 30, 1997
                                   (Unaudited)


1.       Company Overview

         Lynx has developed a unique, proprietary technology for the analysis of
DNA called Massively Parallel Signature  Sequencing,  or MPSS. MPSS, the Company
believes,  is the only technology available today that can analyze and identify,
simultaneously,  very large numbers of DNA molecules or fragments  from a single
biological  sample.  Lynx's technology has three major  applications and each of
these  can  be  applied  to  the  genomes  of  man,  pathogenic   organisms  and
commercially  important plants and animals.  These three major  applications are
gene expression analysis, genomic sequencing and high resolution genomic maps.

         In 1995, Lynx launched an internal biology-based drug discovery program
to  establish  the  concepts,   strategies  and  techniques  necessary  for  the
identification  of drug  targets  based on the  analysis  of  differential  gene
expression.  This program is designed to  capitalize  eventually on the power of
MPSS  but  in  its  early  phase  it  is  utilizing  know-how  and  intermediate
technologies  currently  resident within Lynx. The initial projects are centered
on the medically important field of neurovascular diseases that are particularly
well suited to analyses with the Company's gene sequencing and target  discovery
(MPSS) technologies.

         Lynx was originally  formed in late 1992 to target  inappropriate  gene
expression  in disease with  synthetic  DNA  fragments  designed to bind to, and
functionally  block,  genes whose  inappropriate  expression could be correlated
with disease. Lynx's early efforts at identifying and targeting gene function in
disease were based on the research of academic  collaborators using conventional
techniques.  The research  efforts have resulted in a compound  (LR-3280) now in
Phase II  clinical  trials for the  prevention  of coronary  artery  restenosis.
Lynx's early efforts in this area have formed the foundation  and  understanding
for the development of its new genetic technologies.

2.       Basis of presentation

         The condensed  consolidated  financial  statements included herein have
been  prepared  by  the  Company  without  audit,  pursuant  to  the  rules  and
regulations   promulgated  by  the  Securities  and  Exchange   Commission  (the
"Commission"). Certain prior year amounts have been reclassified to conform with
current year presentation. Certain information and footnote disclosures normally
included in financial  statements prepared in accordance with generally accepted
accounting  principles  have  been  omitted  pursuant  to  Commission  rules and
regulations;  nevertheless,  the  Company  believes  that  the  disclosures  are
adequate  to make  the  information  presented  not  misleading.  The  financial
statements  include  all  accounts  of  the  Company  and,  in  the  opinion  of
management,  contain  all  adjustments,  consisting  only  of  normal  recurring
adjustments,  necessary to present  fairly the  financial  position,  results of
operations, and cash flows of the Company for the interim periods presented. The
results of operations  for the three and six months ended June 30, 1997, are not
necessarily indicative of the results for the full year.

         These  financial  statements  should  be read in  conjunction  with the
audited  consolidated  financial  statements and notes thereto for the Company's
year ended December 31, 1996.

3.       Net loss per share

         In 1997, the Financial  Accounting  Standards Board issued Statement of
Financial  Accounting  Standards  No. 128  ("SFAS  128"),  "Earnings  Per Share"
("EPS").  SFAS 128 requires that companies


                                                                    Page 6 of 11
<PAGE>

present two measures of earnings per share,  basic and diluted.  Basic  earnings
per share is computed by dividing income available to common shareholders by the
weighted-average  number of common  shares  outstanding  for the  period,  while
diluted EPS reflects the potential  dilution of  securities  that could share in
the  earnings  of the  company.  SFAS 128 is  effective  for  interim and annual
periods  ending  after  December  15,  1997.  The  Company  does not believe the
adoption  of SFAS  128  will  have a  material  impact  on its  loss  per  share
calculations.


Item 2.           Management's  Discussion  and Analysis of  Financial Condition
                  and Results of Operations

         Except for the historical  information  contained herein, the following
discussion   contains   forward-looking   statements   that  involve  risks  and
uncertainties.  The Company's actual results could differ  materially from those
discussed  here.  Factors  that could cause or  contribute  to such  differences
include,  but are not limited to, those discussed in this section, as well as in
the Company's  annual report (Form 10-K) filed with the  Securities and Exchange
Commission for the fiscal year ended December 31, 1996.

Overview

         Lynx  has  been   unprofitable   since  its  inception  and  may  incur
substantial losses for the next several years, due primarily to the expansion of
its research and development programs,  including additional  development of its
MPSS  technology.  Lynx  may  generate  revenues  based on its  agreements  with
collaborative  partners as a result of achievement of the milestones  defined in
the  agreements.  However,  there is no guarantee  that the  milestones  will be
achieved  or that the  technologies  will be  proven  successful.  Lynx does not
anticipate that it will generate  significant revenues and profits, if any, from
the  commercial  sale of its products and  services  for several  years,  if not
longer.  There can be no assurance that Lynx will ever successfully  develop and
market any of its  proposed  products or that it will ever be able to achieve or
sustain profitability.

         Lynx's  business is subject to significant  risks,  including the risks
inherent in its research and development efforts,  uncertainties associated with
obtaining and enforcing patents,  the lengthy and expensive  regulatory approval
process,  and  possible  competition  from other  products.  The MPSS program is
dependent upon the successful integration of independent  technologies,  each of
which has its own development  risks. In addition,  Lynx's MPSS technology could
face  competition  from the  development  of  similarly  efficient,  or  better,
combinations  of  novel  cloning  and  sequencing  techniques.  Even  if  Lynx's
therapeutic  compounds appear  promising at an early stage of development,  they
may not reach the market for a number of reasons.  Such reasons  include but are
not limited to the  possibilities  that the  compounds  are found to be toxic or
ineffective during clinical trials, the failure to receive necessary  regulatory
approvals,  the difficulty to manufacture on a large scale,  or the inability to
market a compound due to proprietary rights of third parties.

Results of Operations

Revenue

         Lynx had total revenues of approximately  $1.3 million and $462,000 for
the quarters  ended June 30, 1997 and 1996,  respectively.  The 1997 revenue was
comprised of approximately  $1.2 million earned under  collaborative  agreements
with corporate  partners,  $85,000 in product revenue and $13,000 earned under a
government  grant.  The 1996 revenue was  comprised  of $375,000  earned under a
collaborative  agreement  with a corporate  partner  and  $87,000  earned from a
government grant.

         Lynx had revenues of approximately $2.5 million and $954,000 in the six
months ended June 30, 1997 and 1996, respectively. The 1997 revenue consisted of
approximately $2.3 million in collaborative


                                                                    Page 7 of 11

<PAGE>

revenue,  $85,000 in product  revenue  and  $85,000 in grant  revenue.  The 1996
revenue was comprised of $750,000 in  collaborative  revenue and $204,000 earned
from a government grant.

         Revenue will  continue to fluctuate  based on activity with current and
potential  corporate  partners,   achievement  of  milestones,   and  timing  of
government grant funding.

Operating Expenses

         Research and development expenses were $3.4 million and $2.9 million in
the three months ended June 30, 1997 and 1996,  respectively.  For the six-month
periods ending on June 30, 1997 and 1996, research and development expenses were
$6.5 million and $5.3 million, respectively. The increases were due to the costs
associated with increased levels of research and development personnel,  and the
amortization of deferred compensation recorded in conjunction with the Agreement
of Merger between Lynx and its majority owned  subsidiary,  Spectragen,  Inc. in
November 1996. The increases  were  partially  offset by reduced  company-funded
sponsored  research.  Lynx expects to incur substantial and increasing  research
and  development  expenses  due to planned  spending  for ongoing  research  and
development activities and new research applications.

         General and administrative expenses were $591,000 for the quarter ended
June 30,  1997,  compared to $628,000 for the quarter  ended June 30, 1996.  The
decrease  was  due to  lower  outside  professional  fees,  and  slightly  lower
headcount-related expenses.

         General  and  administrative  expenses  were $1.0  million  for the six
months  ended June 30,  1997,  compared to $1.2 million for the six months ended
June 30, 1996. The decrease was due to lower  headcount-related  expenses and to
lower investor  relations  costs compared to 1996.  Investor  relations costs in
1996 reflected the costs of the reverse stock split. Lynx expects to continue to
incur  substantial  administrative  expenses  in  support  of its  research  and
development efforts.

Interest Income

         Interest  income was  $133,000  and $143,000 for the three months ended
June 30, 1997 and 1996, respectively. For the six months ended June 30, 1997 and
1996, interest income was $304,000 and $330,000, respectively.

Liquidity and Capital Resources

         Net cash used in operating activities of approximately $6.1 million for
the six months ended June 30, 1997 differs from the net loss for the same period
primarily due to current period recognition of a portion of previously  deferred
revenue,  offset  in  part  by  depreciation  and  amortization,   and  deferred
compensation  expense.  Net cash  provided by  investing  activities  related to
maturities of short-term  investments  partially offset by costs associated with
purchases of capital equipment and the expansion of laboratory facilities.  Lynx
expects that future capital expenditures will be commensurate with growth in the
employee base and the  development of its MPSS and other  technologies.  At June
30, 1997, Lynx's cash and cash equivalents were $6.7 million.

         Lynx is currently  utilizing its available funds to support development
of its  MPSS  and  other  technologies,  and to fund  preclinical  research  and
clinical trials.  Pending such uses as described  above,  Lynx intends to invest
its excess cash in short-term,  investment grade, interest-bearing securities or
certificates of deposit.

         Since  commencing  operations  as  an  independent  company,  Lynx  has
obtained funding for its operations  through sales of preferred and common stock
to  venture  capital   investors  and  collaborative   partners,   revenue  from
collaborative  research and development  arrangements,  interest income, product
sales, and government  grants. The cost, timing and amount of funds required for
specific  uses by Lynx cannot be precisely  determined  at this time and will be
based upon  Lynx's  progress  in its  research  and


                                                                    Page 8 of 11
<PAGE>

development,  the scope and results of preclinical research and clinical trials,
the cost and timing of regulatory approvals, administrative and legal costs, the
establishment  of  corporate  collaborations  and  other  arrangements,  and the
availability  of alternate  methods of  financing.  Lynx may receive  additional
collaborative  research  payments from its existing partners  (Hoechst,  Tanabe,
Schwarz  Pharma  and BASF) and  equity  investments  from  Hoechst,  subject  to
achieving the milestones set forth in the various agreements. Lynx may also seek
to raise additional funding through the sale of its equity securities or through
corporate  collaborations  and other  arrangements  with  existing or  potential
corporate  partners.  There can be no assurance  that any  additional  financing
required by Lynx will be available or, if available,  will be on terms favorable
to Lynx.  The  failure to obtain  such  financing  may cause the Company to seek
other sources of capital or reevaluate its operating  plans.  Lynx believes that
its current cash and cash equivalents and interest income thereon will enable it
to maintain its current operations through the end of 1997.


                                                                    Page 9 of 11

<PAGE>


PART II           OTHER INFORMATION

Item 1.           Legal Proceedings

                      None

Item 2.           Changes in Securities

                      None

Item 3.           Defaults upon Senior Securities

                      None

Item 4.           Submission of Matters to a Vote of Security Holders

                  At the  annual  meeting  of  shareholders  held May 13,  1997,
shareholders voted on the following:


                  (1) Election of Directors:

                      Nominee                       For             Withheld
                      -------                       ---             --------

                      Sam Eletr                  1,942,842          133,610
                      Sydney Brenner             1,942,893           95,844
                      Kathleen D. La Porte       1,942,893           95,653
                      William K. Bowes           1,942,842           95,704
                      James C. Kitch             1,937,007          101,539
                      Craig C. Taylor            1,942,902           95,644

                  (2) Ratification of Selection of Independent Auditors:

                      For              Against           Non-Vote
                      ---              -------           --------

                      2,036,025           1,303            --

Item 5.           Other Information

                      None


Item 6.           Exhibits and Reports on Form 8-K.

                      a)   Exhibits  - The  following  document is  filed  as an
                           Exhibit to this report:

                           Exhibit
                           Number                Description
                           -------               -----------

                           27.1                  Financial Data Table

                      b)   No reports on Form 8-K were filed during the  quarter
                           ended June 30, 1997.


                                                                   Page 10 of 11
<PAGE>


                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned, thereunto duly authorized.


                                                         LYNX THERAPEUTICS, INC.


                                            /s/   Sam Eletr
                                            ------------------------------------
                                            By:      Sam Eletr, Ph.D.
                                                     Chief Executive Officer and
                                                     Chairman of the Board
                                            Date:    August 12, 1997


                                            /s/  Edward C. Albini
                                            ------------------------------------
                                            By:      Edward C. Albini
                                                     Chief Financial Officer
                                                     (Principal Financial and
                                                     Accounting Officer)
                                            Date:    August 12, 1997


                                                                   Page 11 of 11

<TABLE> <S> <C>


<ARTICLE>                     5
<LEGEND>
                                THIS SCHEDULE  CONTAINS SUMMARY  FINANCIAL
                                INFORMATION  EXTRACTED  FROM THE QUARTERLY
                                REPORT  PURSUANT TO SECTION 13 OR 15(d) OF
                                THE  SECURITIES  EXCHANGE  ACT OF 1934 FOR
                                THE FORM 10-Q PERIOD ENDED JUNE 30, 1997.
</LEGEND>
<MULTIPLIER>                                   1,000
       
<S>                             <C>
<PERIOD-TYPE>                                        6-MOS
<FISCAL-YEAR-END>                              DEC-31-1997
<PERIOD-START>                                 JAN-01-1997
<PERIOD-END>                                   JUN-30-1997
<CASH>                                               6,718
<SECURITIES>                                             0
<RECEIVABLES>                                          191
<ALLOWANCES>                                             0
<INVENTORY>                                              0
<CURRENT-ASSETS>                                     6,976
<PP&E>                                               7,412
<DEPRECIATION>                                      (2,921)
<TOTAL-ASSETS>                                      11,656
<CURRENT-LIABILITIES>                                4,257
<BONDS>                                                  0
                                    0
                                         27,189
<COMMON>                                            17,469
<OTHER-SE>                                         (38,339)
<TOTAL-LIABILITY-AND-EQUITY>                        11,656
<SALES>                                                  0
<TOTAL-REVENUES>                                     2,457
<CGS>                                                    0
<TOTAL-COSTS>                                            0
<OTHER-EXPENSES>                                     7,469
<LOSS-PROVISION>                                         0
<INTEREST-EXPENSE>                                       0
<INCOME-PRETAX>                                     (4,708)
<INCOME-TAX>                                             0
<INCOME-CONTINUING>                                 (4,708)
<DISCONTINUED>                                           0
<EXTRAORDINARY>                                          0
<CHANGES>                                                0
<NET-INCOME>                                        (4,708)
<EPS-PRIMARY>                                        (1.49)
<EPS-DILUTED>                                        (1.49)
        


</TABLE>


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