LYNX THERAPEUTICS INC
10-Q, 1998-05-13
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM 10-Q


X    QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
     ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 1998.

                                       OR

     TRANSITION  REPORT  PURSUANT  TO  SECTION  13 OR  15(d)  OF THE  SECURITIES
     EXCHANGE  ACT OF  1934  FOR  THE  TRANSITION  PERIOD  FROM  ___________  TO
     ___________.


                         Commission File Number 0-22570


                             Lynx Therapeutics, Inc.
             (Exact name of registrant as specified in its charter)

            Delaware                                             94-3161073
(State or other jurisdiction of                              (I.R.S. Employer
 incorporation or organization)                             Identification No.)


        3832 Bay Center Place
             Hayward, CA                                             94545
(Address of principal executive offices)                          (Zip Code)


                                 (510) 670-9300
              (Registrant's telephone number, including area code)


Indicate by check mark whether the registrant (1) has filed all reports required
to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during
the  preceding 12 months (or for such  shorter  period that the  Registrant  was
required  to file  such  reports),  and  (2) has  been  subject  to such  filing
requirements for the past 90 days.

                                    Yes X   No   

The  number of shares of Common  Stock  outstanding  as of April 30,  1998,  was
11,099,718.  The  aggregate  market value of the common stock of the  Registrant
held by non-affiliates as of April 30, 1998 was $87,186,929.

                                                                    Page 1 of 13

<PAGE>


                             Lynx Therapeutics, Inc.


                                      INDEX


PART I      FINANCIAL INFORMATION                                           Page
                                                                            ----

Item 1.     Condensed Consolidated Balance Sheets - March 31, 1998
                and December 31, 1997........................................ 3

            Condensed Consolidated Statements of Operations - three months
                 ended March 31, 1998 and 1997............................... 4

            Condensed Consolidated Statements of Cash Flows - three months
                ended March 31, 1998 and 1997................................ 5

            Notes to Condensed Consolidated Financial Statements............. 6

Item 2.     Management's Discussion and Analysis of
                Financial Condition and Results of Operations................ 8


PART II     OTHER INFORMATION

Item 1.     Legal Proceedings................................................10

Item 2.     Changes in Securities............................................10

Item 3.     Defaults Upon Senior Securities..................................10

Item 4.     Submission of Matters to a Vote of Security Holders..............10

Item 5.     Other Information................................................10

Item 6.     Exhibits and Reports on Form 8-K.................................10

Signatures  .................................................................11

                                                                    Page 2 of 13

<PAGE>


PART I            FINANCIAL INFORMATION
Item 1.           Financial Statements

<TABLE>
                                                       Lynx Therapeutics, Inc.
                                                CONDENSED CONSOLIDATED BALANCE SHEETS
                                                           (In thousands)

<CAPTION>
                                                                                                    March 31,           December 31,
                                                                                                      1998                  1997*
                                                                                                    -------------------------------
                                                                                                   (Unaudited)
<S>                                                                                                 <C>                    <C>     
Assets
Current assets:
   Cash and cash equivalents                                                                        $ 15,379               $  8,798
   Short-term investments                                                                              8,720                 16,132
   Accounts receivable                                                                                   350                    244
   Other current assets                                                                                  163                    199
                                                                                                    -------------------------------
Total current assets                                                                                  24,612                 25,373

Property and equipment:
   Leasehold improvements                                                                              3,803                  3,795
   Laboratory and other equipment                                                                      2,807                  3,562
                                                                                                    -------------------------------
                                                                                                       6,610                  7,357
   Less accumulated depreciation and amortization                                                     (2,709)                (3,588)
                                                                                                    -------------------------------
Net property and equipment                                                                             3,901                  3,769

Notes receivable from employees                                                                           49                    125
Long-term investments                                                                                  1,747                   --
                                                                                                    -------------------------------
                                                                                                    $ 30,309               $ 29,267
                                                                                                    ===============================
Liabilities and stockholders' equity
Current liabilities:
   Accounts payable                                                                                 $  1,299               $    210
   Accrued compensation                                                                                  177                    289
   Accrued professional fees                                                                             151                    179
   Deferred revenue from related parties                                                               1,604                  2,292
   Other accrued liabilities                                                                             437                    528
                                                                                                    -------------------------------
Total current liabilities                                                                              3,668                  3,498

Other noncurrent liabilities                                                                             187                    179

Stockholders' equity:
   Preferred stock                                                                                      --                   27,189
   Common stock                                                                                       74,357                 46,640
   Notes receivable from stockholders                                                                   (460)                  (460)
   Deferred compensation                                                                              (5,064)                (5,394)
   Accumulated other comprehensive income (loss)                                                         (31)                   (45)
   Accumulated deficit                                                                               (42,348)               (42,340)
                                                                                                    -------------------------------
Total stockholders' equity                                                                            26,454                 25,590
                                                                                                    ===============================
                                                                                                    $ 30,309               $ 29,267
                                                                                                    ===============================

<FN>
*    The Balance  Sheet  amounts at December 31, 1997 have been derived from audited  financial  statements  at that date but do not
     include all of the  information  and footnotes  required by generally  accepted  accounting  principles for complete  financial
     statements.

                                                       See accompanying notes.
</FN>

                                                                                                                        Page 3 of 13

</TABLE>

<PAGE>


                             Lynx Therapeutics, Inc.
                 CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                    (In thousands, except per share amounts)
                                   (Unaudited)


                                                            Three Months Ended
                                                                March 31,
                                                           --------------------
                                                             1998         1997
                                                           -------      -------

 Net revenues:
    Revenues from collaborative arrangements with          $   688      $ 1,063
    related parties
    Other revenues                                             126           72
                                                           --------------------
 Total revenues                                                814        1,135

 Operating  expenses:
    Research and development                                 3,842        3,075
    General and administrative                                 492          425
                                                           --------------------
 Total operating  expenses                                   4,334        3,500
                                                           --------------------

 Loss from operations                                       (3,520)      (2,365)

 Interest income                                               336          171
 Gain on sale of Antisense Business                          3,176         --
                                                           --------------------
 Net loss                                                  $    (8)     $(2,194)
                                                           ====================

 Basic and diluted net loss per share                      $ (0.00)     $ (0.80)
                                                           ====================

 Shares used in per share computation                        5,729        2,759
                                                           ====================

                             See accompanying notes.

                                                                    Page 4 of 13

<PAGE>


<TABLE>
                                                       Lynx Therapeutics, Inc.
                                           CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                                           (In thousands)
                                                             (Unaudited)

<CAPTION>
                                                                                                           Three Months Ended
                                                                                                                March 31,
                                                                                                        ---------------------------
                                                                                                          1998               1997
                                                                                                        --------           --------
<S>                                                                                                     <C>                <C>      
Cash flows from operating activities
Net loss                                                                                                $     (8)          $ (2,194)
Adjustments to reconcile net loss to net cash used in operating activities:
     Depreciation and amortization                                                                           355                300
     Amortization of deferred compensation                                                                   330                180
     Non-cash consideration received and costs incurred on the sale of the
       Antisense Business, net                                                                              (417)              --
     Changes in operating assets and liabilities:
         Accounts receivable                                                                                (106)                46
         Other current assets                                                                                 36                 67
         Accounts payable                                                                                  1,089                 74
         Accrued liabilities                                                                                (231)              (191)
         Deferred revenue from related party                                                                (688)            (1,063)
         Other noncurrent liabilities                                                                          8                  8
                                                                                                        ---------------------------
Net cash provided by (used in) operating activities                                                          368             (2,773)

Cash flows from investing activities
Purchases of short-term investments                                                                       (5,667)              --
Maturities of short-term investments                                                                      13,093              1,975
Purchases of long-term investments                                                                          (865)              --
Purchases of property and equipment                                                                         (697)              (865)
Notes receivable from employees                                                                               (9)                (5)
                                                                                                        ---------------------------
Net cash provided by investing activities                                                                  5,855              1,105

Cash flows from financing activities
Issuance (repurchase) of common stock                                                                        358                (32)
                                                                                                        ---------------------------
Net cash provided by (used in) financing activities                                                          358                (32)
                                                                                                        ---------------------------

Net increase (decrease) in cash and cash equivalents                                                       6,581             (1,700)
Cash and cash equivalents at beginning of period                                                           8,798             12,109
                                                                                                        ---------------------------
Cash and cash equivalents at end of period                                                              $ 15,379           $ 10,409
                                                                                                        ===========================

<FN>
                                                       See accompanying notes.
</FN>

                                                                                                                        Page 5 of 13

</TABLE>

<PAGE>


                             Lynx Therapeutics, Inc.
              NOTES TO CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

                                 March 31, 1998
                                   (Unaudited)


1.       Ownership and Nature of Business

         Lynx Therapeutics,  Inc. ("Lynx" or the "Company"), was incorporated in
February  1992 under the laws of the State of Delaware.  Lynx has spent the last
several years developing unique, proprietary technologies designed to enable the
simultaneous  identification  and  analysis  of all  (or  nearly  all)  the  DNA
molecules or fragments in a single  biological  sample.  Utilizing its massively
parallel solid phase  cloning,  massively  parallel  hybridization  arrays,  and
massively parallel sequencing technologies, Lynx expects eventually to probe for
genetic and genomic  information  in a much more  efficient  manner than current
technologies.   The  proposed   applications   of  Lynx's   massively   parallel
technologies  include gene discovery,  gene expression,  high resolution  genome
mapping  and  the  identification  of  genetic  variations.   Lynx  expects  its
technologies will be applicable to the genomes of man, pathogenic organisms, and
commercially  important plants and animals.  Lynx believes that its technologies
will open new avenues to understanding  genetics and the  relationships  between
gene function and the various states from health to disease.

2.       Basis of Presentation

         The accompanying  condensed  consolidated financial statements included
herein have been prepared by the Company  without  audit,  pursuant to the rules
and  regulations  promulgated  by the Securities  and Exchange  Commission  (the
"Commission"). Certain prior year amounts have been reclassified to conform with
current year presentation. Certain information and footnote disclosures normally
included in financial  statements prepared in accordance with generally accepted
accounting  principles  have  been  omitted  pursuant  to  Commission  rules and
regulations;  nevertheless,  the  Company  believes  that  the  disclosures  are
adequate to make the  information  presented not  misleading.  In the opinion of
management, the financial statements contain all adjustments, consisting only of
normal  recurring  adjustments,   necessary  to  present  fairly  the  financial
position,  results of  operations  and cash flows of the Company for the interim
periods  presented.  The results of  operations  for the quarter ended March 31,
1998, are not necessarily indicative of the results for the full year.

         The unaudited condensed  consolidated  financial statements include all
accounts of the Company and its wholly owned subsidiary, Lynx GmbH, formed under
the laws of the  Federal  Republic  of  Germany.  All  significant  intercompany
balances have been eliminated.

         These  financial  statements  should  be read in  conjunction  with the
audited  consolidated  financial  statements and notes thereto for the Company's
year ended  December 31, 1997,  included in its annual report on Form 10-K filed
with the Securities and Exchange Commission.

3.       Summary of Significant Accounting Policies

Net Loss Per Share

         In 1997,  the Financial  Accounting  Standards  Board  ("FASB")  issued
Statement of Financial  Accounting Standards No. 128 ("SFAS" 128), "Earnings Per
Share"  ("EPS"),  effective for periods ending after December 15, 1997. SFAS 128
requires that  companies  present two measures of earnings per share,  basic and
diluted.

         Basic  loss per share is  calculated  by  dividing  net  income or loss
applicable  to common  shareholders  by the  weighted  average  number of common
shares  outstanding,  net of certain common shares outstanding which are subject
to continued  vesting and the Company's  right of repurchase,  while diluted EPS
reflects the potential  dilution of securities  that could share in the earnings
of the company,  to the extent such  securities are dilutive.  Basic and diluted
loss per  share are  equivalent  for all  periods  presented  herein  due to the
Company's  net loss.  The Company  has  adopted  SFAS 128 for annual and interim
financial  statements  issued after  December 15, 1997,  and has  calculated and
restated  EPS in  accordance  with  SFAS 128 for each  period in which an income
statement is reported.  The following have been excluded from the calculation of
loss  per  share  because  the  effect  of  inclusion  would  be   antidilutive:
approximately 270,000 common shares which are outstanding but are subject to the
Company's right of repurchase which expires ratably over 5 years, and options to
purchase  approximately  1,400,000  shares of common stock at a weighted average
price of $4.67 per share.  Additionally,  all  periods  prior to March 31,  1998

                                                                    Page 6 of 13

<PAGE>


exclude approximately 500,000 shares of Series B, C, and D convertible preferred
stock.  On March 31, 1998,  the preferred  stock  converted to common stock on a
ten-for-one  basis.  The  converted  shares  are,  and will be,  included in the
calculations of basic EPS in all periods including, and subsequent to, March 31,
1998. (See Note 5)

Comprehensive Income

         As of January 1, 1998,  the  Company  adopted  Statement  of  Financial
Accounting  Standards,  No. 130 ("SFAS  130"),  Comprehensive  Income.  SFAS 130
establishes new rules for the reporting and display of comprehensive  income and
its components.  SFAS 130 requires  unrealized  gains or losses on the Company's
available-for-sale  securities, which prior to adoption were reported separately
in shareholders'  equity, to be included in other  comprehensive  income.  Prior
year financial  statements have been reclassified to conform to the requirements
of SFAS 130.

         During the first  quarter of 1998 and 1997,  total  comprehensive  loss
amounted to $39,000 and $2.2 million, respectively.

4.       Sale of the Antisense Business

         On  March  10,  1998,  Lynx  sold  its  portfolio  of  phosphorothioate
antisense   patents   and   licenses,   and  its   therapeutic   oligonucleotide
manufacturing  facility  (collectively,   the  "Antisense  Business"),  to  Inex
Pharmaceuticals   Corporation   ("Inex")   a   Canadian   company.   As  partial
consideration  in this  transaction,  Lynx  received $3 million in cash and will
receive 1.2 million  shares of Inex common stock,  in three equal  installments,
with the first  400,000  shares  received on the above date,  and the second and
third  installments  of stock to be received no later than two and three  years,
respectively,  from the closing date of the  transaction.  The Inex common stock
received  by Lynx is subject to certain  restrictions  on trading  for  specific
periods of time  following  receipt by Lynx.  Lynx is also  entitled  to receive
royalties on future sales of phosphorothioate  antisense products.  In addition,
Lynx has agreed to a  royalty-bearing  license to Inex for its  phosphoroamidate
chemistry  for  certain  therapeutic  applications  in the  fields of cancer and
inflammation that will be defined later.

         The gain on the sale of the Antisense Business is based on the cash and
the first installment of the Inex common stock received on the transaction date,
net of the book value of the assets  transferred to Inex and certain other costs
associated  with the  transaction and incurred by Lynx. The Inex common stock is
classified in long term assets.

5.        Conversion of Preferred Stock to Common Stock

         On March 31, 1998, pursuant to the Amended and Restated  Certificate of
Designation  dated  September 30, 1997, all of the shares of Series B, Series C,
and Series D preferred  stock were  converted into common stock on a ten-for-one
basis.  The inclusion of these shares in both the basic and diluted earnings per
share will have a  significant  impact on the earnings per share amounts in 1998
and  subsequent  years.  The net loss per share for the quarter ending March 31,
1998,  would have been  $(0.00) if the Series B, Series C and Series D preferred
stock were converted to common stock on January 1, 1998.

6.       New Facility Lease

         On February 27, 1998, the Company  entered into a  noncancelable  lease
for additional facilities space. The term of the lease commences on December 15,
1998 and expires on December 14, 2008. Under the terms of the lease, the monthly
rental  payments are fixed for the first  twenty-four  months.  Thereafter,  the
monthly  rental  payments  increase,  and are subject to annual  Consumer  Price
Index-based  adjustments,  with minimum and maximum limits.  The Company has the
option  to extend  the lease for an  additional  five year  period,  subject  to
certain  conditions,  with payments to be determined at the time of the exercise
of  such  option.  Additionally,  the  Company  has an  option  (the  "Expansion
Option"),  exercisable  on or prior to  January  1,  2000,  to lease  additional
building space for expansion  purposes.  In return for the Expansion Option, the
Company  may be  subject to a nominal  carrying  cost on the  additional  space,
depending on the timing of the exercise of such option, if ever.

                                                                    Page 7 of 13

<PAGE>


Item 2.  Management's Discussion and Analysis of Financial Condition and Results
        of Operations

         Except for the historical  information  contained herein, the following
discussion   contains   forward-looking   statements   that  involve  risks  and
uncertainties.  The Company's actual results could differ  materially from those
discussed  here.  Factors  that could cause or  contribute  to such  differences
include,  but are not limited to, those discussed in this section, as well as in
the Company's  annual report (Form 10-K) filed with the  Securities and Exchange
Commission for the fiscal year ended December 31, 1997.

Overview

Results of Operations

Revenue

         Revenue was $0.8 million and $1.1 million for the quarters  ended March
31, 1998 and 1997, respectively.  Revenues for 1998 included $0.7 million earned
under a collaborative  agreement with BASF AG ("BASF"),  and approximately  $0.1
million in other revenue,  primarily  compound for use in clinical  trials.  The
1997  revenues  included $0.7 million from BASF and $0.4 million from Hoechst AG
and Hoechst Marion Roussel (collectively,  "Hoechst") earned under collaborative
agreements.  Revenue will  continue to fluctuate  based on activity with current
and potential corporate partners and achievement of milestones.

Operating Expenses

         Research and development expenses were $3.8 million and $3.1 million in
the quarters ended March 31, 1998 and 1997,  respectively.  The increase was due
to  the  building  of  production   capacity  for  the  anticipated   commercial
application of the Company's novel, proprietary massively parallel technologies,
and to higher  amortization  of  deferred  compensation  related to the grant of
stock options, partially offset by reduced funding to various laboratories under
collaborative  research  agreements.  Lynx  expects  to  incur  substantial  and
increasing research and development expenses due to planned spending for ongoing
technology development and implementation, and new research applications.

         General and administrative expenses were $492,000 for the quarter ended
March 31, 1998,  compared to $425,000 for the quarter ended March 31, 1997.  The
increase was due to higher headcount-related  expenses. Lynx expects to continue
to incur  substantial  administrative  expenses in support of its  research  and
development efforts.

Interest Income

         Interest  income was $336,000 and $171,000 for the quarters ended March
31, 1998 and 1997  respectively.  The increase was due to a higher  average cash
balance in the quarter ended March 31, 1998 than in the same quarter in 1997.

Gain on Sale of Antisense Business

         Other income of $3.2  million for the quarter  ended March 31, 1998 was
comprised  of the  gain on the  sale of  Lynx's  portfolio  of  phosphorothioate
antisense   patents   and   licenses,   and  its   therapeutic   oligonucleotide
manufacturing  facility   (collectively,   the  "Antisense  Business")  to  Inex
Pharmaceuticals   Corporation   ("Inex").   As  partial  consideration  in  this
transaction,  Lynx  received  $3 million in cash and will  receive  1.2  million
shares of Inex common stock, in three equal installments, with the first 400,000
shares  received on March 10,  1998,  and the second and third  installments  of
stock to be received no later than two and three years,  respectively,  from the
closing  date of the  transaction.  The Inex  common  stock  received by Lynx is
subject  to  certain  restrictions  on  trading  for  specific  periods  of time
following receipt by Lynx.

         The gain on the sale of the Antisense Business reflects on the cash and
the first installment of the Inex common stock received on the transaction date,
net of the book value of the assets  transferred to Inex and certain other costs
associated with the transaction and incurred by Lynx.

                                                                    Page 8 of 13

<PAGE>


Liquidity and Capital Resources

         Net cash  provided by operating  activities of $367,000 for the quarter
ended March 31,  1998,  differed  from the net loss for the same period in 1997,
primarily due to increases in payables,  the non-cash consideration received and
costs incurred on the sale of the Antisense Business, current period recognition
of a portion of previously deferred revenue, depreciation and amortization,  and
deferred compensation expense. Net cash provided by investing activities related
to maturities of short-term investments partially offset by purchases of capital
equipment.  Net cash provided by financing activities related to the exercise of
stock options by employees. Cash and equivalents were $15.4 million at March 31,
1998.

         Lynx   plans  to  use   available   funds  for  the   development   and
implementation of its massively parallel  technologies and to build capacity for
their early commercial uses.  Pending such uses as described above, Lynx intends
to invest its excess  cash in  short-term,  investment  grade,  interest-bearing
securities or certificates of deposit.

         Since  commencing  operations  as  an  independent  company,  Lynx  has
obtained funding for its operations  through sales of preferred and common stock
to  venture  capital  investors,   institutional  investors,  and  collaborative
partners;  revenue from  collaborative  research and  development  arrangements,
interest income,  product sales, and government  grants.  The cost,  timing, and
amount  of  funds  required  for  specific  uses by  Lynx  cannot  be  precisely
determined  at this time and will be based upon Lynx's  progress in its research
and development,  administrative and legal costs, the establishment of corporate
collaborations and other arrangements, and the availability of alternate methods
of financing.

         Lynx  expects  to  incur   substantial  and  increasing   research  and
development  expenses  and  intends  to seek  additional  financing,  as needed,
through  contractual  arrangements  with  corporate  partners and equity or debt
offerings.  There can be no assurance that any additional  financing required by
Lynx will be available or, if available, will be on terms favorable to Lynx. The
Company  believes  that,  at  current  spending  levels,  its  existing  capital
resources and interest income thereon will enable it to maintain its current and
planned operations at least through mid-1999.

Impact of Year 2000

         The Company has  completed  an  assessment  of its  computer  operating
systems and related  software and, with only a few minor  exceptions,  has found
them to be Year 2000  compliant.  The  Company's  exposure is limited due to the
fact that most of its computers and software were acquired  within the past five
years and were Year 2000 compliant at purchase. The Company plans to replace the
operating  systems on the few  non-compliant  computers  before 2000 and expects
that the  cost  will be  immaterial.  The  Company  believes  that  even if such
modifications  are not made,  there  will be no  adverse  impact on  operations.
However,  Year 2000  problems may affect the computer  systems of the  Company's
business partners,  vendors, customers, and financial service organizations with
which the Company interacts.  The Company is in the process of developing a plan
to determine the impact that third parties which are not Year 2000 compliant may
have on the operations of the Company.  There can be no assurance that such plan
will be able to address fully, or at all, the "Year 2000 issue" which could have
a material adverse effect upon the Company's  business, financial  condition and
results of operations.

                                                                    Page 9 of 13

<PAGE>


PART II           OTHER INFORMATION

Item 1.           Legal Proceedings
                      None

Item 2.           Changes in Securities
                      None

Item 3.           Defaults upon Senior Securities
                      None

Item 4.           Submission of Matters to a Vote of Security Holders
                      None

Item 5.           Other Information
                      None

Item 6.           Exhibits and Reports on Form 8-K.

                      a)  Exhibits  -  The  following  documents  are  filed  as
Exhibits to this report:

                           Exhibit
                           Number         Description
                           ------         -----------

                           10.35*         Lease,  dated as of February 27, 1998,
                                          between the Company and SimFirst, L.P.
                                          limited partnership

                           27.1           Financial Data Schedule


                          *Portions of this agreement have been deleted pursuant
                           to our request for confidential treatment.

                      b)   The  Company  filed a  Current  Report on Form 8-K on
                           March  24,  1998,  reporting  under  Item 2 that  the
                           Company had sold its  portfolio  of  phosphorothioate
                           antisense  patents and licenses,  and its therapeutic
                           oligonucleotide   manufacturing   facility,  to  Inex
                           Pharmaceuticals Corporation of Vancouver, Canada.

                                                                   Page 10 of 13

<PAGE>


                                   SIGNATURES

         Pursuant to the  requirements  of the Securities  Exchange Act of 1934,
the  registrant  has duly  caused  this report to be signed on its behalf by the
undersigned, thereunto duly authorized.


                                            LYNX THERAPEUTICS, INC.

                                            /s/  Sam Eletr
                                            ------------------------------------
                                            By:      Sam Eletr, Ph.D.
                                                     Chief Executive Officer and
                                                     Chairman of the Board
                                            Date:    May 13, 1998


                                            /s/  Edward C. Albini
                                            ------------------------------------
                                            By:      Edward C. Albini
                                                     Chief Financial Officer
                                                     (Principal Financial and
                                                     Accounting Officer)
                                            Date:    May 13, 1998

                                                                   Page 11 of 13



                                                                   Exhibit 10.35

            Lease, dated as of February 27, 1998, between the Company
                     and SimFirst, L.P. limited partnership.

                                                                   Page 12 of 13

<PAGE>


                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                               UNDER 17 C.F.R. SS. 200.80(B)(4),
                                                            200.83 AND 240.24B-2


                                    NET LEASE
                             BASIC LEASE INFORMATION

DATE:                February 27, 1998

LANDLORD:            SimFirst, L.P., a California limited partnership

TENANT:              Lynx Therapeutics, Inc., a Delaware corporation

PREMISES:            All of Building B (73,920 rentable square feet) (the "Phase
                     I Premises")  Second  floor of Building C (36,960  rentable
                     square feet) (the "Phase II Premises")

PROPERTY:            Mt. Eden Business Park, Hayward, CA

USE:                 General  Office  purposes and research and  development  of
                     certain biotechnical and chemical products.

TERM:                Approximately ten (10) years and four (4) months

ESTIMATED COMMENCEMENT DATE:               August 15, 1998 (Phase I Premises)
                                           June 1, 1999 (Phase II Premises)

INITIAL BASE RENT:                         See Schedule 1

ESTIMATED RENT COMMENCEMENT DATE:          December 15, 1998 (Phase I Premises)
                                           October 1, 1999 (Phase II Premises)

TENANTiS PERCENTAGE SHARE:                 100%  (Phase I Premises)
                                           50% (Phase II Premises)

SECURITY DEPOSIT:                          $[...***...]*1

BROKERS:                                   CB Commercial Real Estate Group, Inc.

                                           Colliers Parish International, Inc.

ADDRESS FOR NOTICES:       Landlord:       SimFirst, L.P.
                                           c/o Simeon Commercial Properties
                                           655 Montgomery Street; Suite 1190
                                           San Francisco, CA 94111

                           Tenant:         Lynx Therapeutics, Inc
                                           3832 Bay Center Place
                                           Hayward, CA 94545

TENANT IMPROVEMENTS ALLOWANCE:             $[...***...] per rentable square foot

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LANDLORD  INITIALS: /s/C.S.                TENANT INITIALS: /s/ E.A.


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                                TABLE OF CONTENTS
                                                                            Page
                                                                            ----

1.    Premises                                                                 1
2.    Term                                                                     1
3.    Rent                                                                     2
4.    Base Rent                                                                2
5.    Operating Expenses                                                       3
6.    Proration of Rent                                                        6
7.    Landlord's Work; Tenant Improvements                                     7
8.    Use of the Premises                                                      7
9.    Alterations                                                              8
10.   Repairs                                                                 11
11.   Damage or Destruction                                                   12
12.   Eminent Domain                                                          13
13.   Indemnity and Insurance                                                 13
14.   Assignment or Sublet                                                    15
15.   Default                                                                 18
16.   Landlord's Right to Perform Tenant's Covenants                          20
17.   Security Deposit                                                        20
18.   Surrender of Premises                                                   20
19.   Holding Over                                                            21
20.   Access to Premises                                                      21
21.   Signs                                                                   21
22.   Subordination                                                           21
23.   Transfer of the Property                                                22
24.   Estoppel Certificates; Financial Statements                             22
25.   Mortgagee Protection                                                    23
26.   Attorneys' Fees                                                         23
27.   Brokers                                                                 23
28.   Parking                                                                 23
29.   Utilities and Services                                                  24
30.   Tenant Relocation                                                       24
31.   Acceptance                                                              24
32.   Use of Building Name                                                    24
33.   Recording                                                               24
34.   Quitclaim                                                               24
35.   Notices                                                                 25
36.   Landlord's Exculpation                                                  25
37.   Additional Structures                                                   25
38.   Consents and Approvals                                                  25
39.   Renewal Option                                                          26
40.   Right of First Offer                                                    26
41.   Expansion Option                                                        28
42.   Licensed Area                                                           29
43.   General                                                                 32


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                             SCHEDULES AND EXHIBITS

SCHEDULE 1:  Base Rent

EXHIBIT "A":  Premises Designation
EXHIBIT "A-1": Property Site Plan
EXHIBIT "B":  Tenant Improvements
EXHIBIT "C":  Commencement Date Memorandum
EXHIBIT "D":  Rules and Regulations
EXHIBIT "E":   Appraisal Procedures



<PAGE>


                                    NET LEASE

         THIS LEASE,  which is  effective  as of the date set forth in the Basic
Lease  Information,  is entered into by Landlord and Tenant, as set forth in the
Basic Lease  Information.  Terms which are  capitalized in this Lease shall have
the meanings set forth in the Basic Lease Information.

1.   Premises.

         Landlord  leases to  Tenant,  and  Tenant  leases  from  Landlord,  the
Premises  described  in the Basic  Lease  Information  (as shown on Exhibit  A),
together  with the right in common to use the Common  Areas.  The  Common  Areas
shall mean the areas and  facilities  within the land shown on Exhibit  A-1 (the
"Land") and all buildings and other improvements now or hereafter located on the
Land  (collectively,  the  "Buildings";  the Land, the Buildings and the "Common
Areas",  collectively,  the  "Property"  or the "Real  Property"),  provided and
designated by Landlord for the general use, convenience or benefit of Tenant and
other  tenants and  occupants  of the  Property  (e.g.,  restrooms;  janitorial,
telephone and  electrical  closets;  sidewalks;  public  lobbies,  entrances and
stairs;  and  unreserved  parking  areas).  Landlord  reserves the right to make
changes to the Common  Areas.  Tenant may improve a portion of the Common  Areas
located  between  Buildings B and C for use as a common  outdoor eating area for
use by Tenant and all other tenants and  permitted  occupants of the Property in
accordance with plans and specifications approved by Landlord, such approval not
to be unreasonably withheld. Tenant acknowledges that any such area shall be and
remain Common Area,  notwithstanding  any funds  expended by Tenant in improving
the same or any course of conduct or practice  which may develop in Tenant being
the only party which chooses to use such area with any frequency.

2.   Term.

         a.  Lease  Term;  Commencement  Date.  The  Term  of this  Lease  shall
commence,  as to each Phase of the  Premises (a "Phase"),  on the date  Landlord
delivers  the Phase to Tenant  with  Landlord's  Base Shell Work (as  defined in
Exhibit B attached hereto) substantially completed ("Landlord's Delivery Date").
In no event shall  Landlord's  Delivery  Date of the Phase I Premises be earlier
than August 15, 1998,  or  Landlord's  Delivery Date of the Phase II Premises be
earlier than June 1, 1999,  unless  Tenant shall agree  thereto in writing.  The
date the Lease term so  commences  with respect to each Phase of the Premises is
referred to herein as the  "Commencement  Date" for such Phase. The term of this
Lease shall end as to the entire  Premises on the last day of the calendar month
in which the tenth (10th) annual  anniversary of the Rent Commencement Date with
respect to the Phase I Premises occurs (the "Expiration Date").

         b. Premises Not Delivered.  If, for any reason, Landlord cannot deliver
possession of any Phase of the Premises to Tenant in the  condition  required by
this Lease by the applicable  Estimated  Commencement  Date, (i) this Lease, and
Tenantis  obligations  hereunder,  shall not commence  until such  possession is
delivered  to Tenant;  (ii) the  failure  shall not affect the  validity of this
Lease,  or,  except as  provided  in  clause  (i) or in the next  sentence,  the
obligations of Tenant under this Lease,  and (iii) Landlord shall not be subject
to any liability. Notwithstanding the foregoing, (i) if the Phase I Commencement
Date shall not have occurred by [...***...],  as such date shall be extended for
any delay in the Phase I Commencement Date caused by Tenant Delay (as defined in
Exhibit B attached hereto), and as such date shall be further extended for up to
one-hundred  eighty  (180)  additional  days  for  any  delay  in

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the Phase I  Commencement  Date  caused by Force  Majeure (as defined in Section
10.c.  below),  Tenant shall have the right to  terminate  this Lease by written
notice to Landlord given within thirty (30) days after such date, as so extended
(such termination to be effective as of the date of Tenant's  notice),  and (ii)
if the Phase II  Commencement  Date shall not have occurred by  [...***...],  as
such date  shall be  extended  for any delay in the Phase II  Commencement  Date
caused by Tenant  Delay (as defined in Exhibit B attached  hereto),  and as such
date shall be further  extended for up to  one-hundred  eighty (180)  additional
days for any delay in the Phase II  Commencement  Date caused by Force  Majeure,
Tenant shall have the right to terminate  this Lease as to the Phase II Premises
only by written  notice to  Landlord  given  within  thirty (30) days after such
date,  as so  extended  (such  termination  to be  effective  as of the  date of
Tenant's  notice).  If this Lease  shall be  terminated  as  provided  under the
foregoing  clause (i),  Landlord  shall  return the  Security  Deposit to Tenant
within thirty (30) days after the termination date.

         c.  Commencement  Date Memorandum.  When the Commencement Date and Rent
Commencement  Date of each Phase is  determined,  the  parties  shall  execute a
Commencement Date Memorandum,  in the form attached hereto as Exhibit C, setting
forth the  applicable  Commencement  Date and Rent  Commencement  Date,  and the
Expiration Date, of this Lease.

         d. Early Entry. If Tenant is permitted by Landlord to enter any portion
of the Premises  prior to the  applicable  Commencement  Date for the purpose of
fixturing or any purpose other than the conduct of Tenantis business,  the entry
shall be subject to all the terms and  provisions  of this  Lease,  except  that
Tenantis  obligation to pay Base Rent and Operating  Expenses shall not commence
until the applicable Rent Commencement  Date.  Without  limitation,  in no event
will  Landlord  consent  to such  early  access  if  Landlord  shall  reasonably
determine that the same might delay Landlord's Delivery Date.

3.   Rent.

         As used in this Lease,  the term  "Rent"  shall  include:  (i) the Base
Rent; (ii) Operating Expenses payable by Tenant pursuant to Section 5 below; and
(iii) all other amounts which Tenant is obligated to pay under the terms of this
Lease.  All amounts of money payable by Tenant to Landlord shall be paid without
prior notice or demand,  deduction or offset. If any installment of Base Rent is
not paid by Tenant by the fifth  (5th) day of the  month,  or if any  payment of
Operating Expenses or any other amount payable by Tenant is not paid within five
(5) days of the due date  thereof,  Tenant  shall pay to Landlord a late payment
charge equal to [...***...] of the amount of the delinquent  amount, in addition
to the amount of Rent then owing,  regardless  of whether a notice of default or
notice of termination has been given by Landlord. In addition to the [...***...]
late charge, any Base Rent,  Operating Expenses or other amounts owing hereunder
which  are not paid  within  five (5) days  after  the date  they are due  shall
thereafter  bear interest at the rate  ("Interest  Rate") which is the lesser of
[...***...] per annum or the maximum rate permitted by applicable law.

4.   Base Rent.

         a. Initial Base Rent. On or before the first day of each calendar month
during the Term,  Tenant  shall pay to  Landlord,  as monthly  Base Rent for the
Premises,  in advance,  at  Landlord's  address for notices (as set forth in the
Basic Lease Information) or at such other address as Landlord may designate, the
monthly Base Rent specified in Schedule I attached  hereto,  provided,  however,
that Tenant's obligation to pay monthly Base Rent for each Phase of the Premises
shall not commence  until the

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Rent Commencement Date for such Phase.  Tenant's  obligation to pay Base Rent as
to each Phase of the Premises shall commence on the date (the "Rent Commencement
Date") which is the earlier to occur of (x) one hundred  twenty (120) days after
Landlord's  Delivery Date of the Phase, or (y) Tenant's occupancy of any portion
of such Phase for the conduct of business. Notwithstanding the foregoing, (i) in
the event that  Landlord's  Delivery Date  applicable to a Phase of the Premises
shall be delayed by reason of Tenant Delay, then for purposes of determining the
Rent  Commencement  Date for such Phase  pursuant to clause (x) of the preceding
sentence,  Landlord's  Delivery  Date  applicable  to such Phase shall be deemed
accelerated by the number of days of such Tenant Delay.

         b. CPI Adjustment.  Commencing with the [...***...] full calendar month
after  the  Phase I  Premises  Rent  Commencement  Date,  and at the end of each
twelfth  (12th) month  thereafter  during the Term,  including any extensions or
renewals,  the Base Rent (for the entire  Premises) for the ensuing  twelve (12)
month period (the  iAdjustment  Periodi) shall be an amount equal to the greater
of (i)  [...***...]%  of the  Base  Rent  in  effect  immediately  prior  to the
commencement  of  such  Adjustment  Period  (without  regard  to  any  temporary
abatement of rental then in effect pursuant to the provisions of this Lease), or
(ii) the product  obtained by  multiplying  the Base Rent in effect  immediately
prior to the  commencement  of such  Adjustment  Period  (without  regard to any
temporary  abatement of rental then in effect pursuant to the provisions of this
Lease),  by a  fraction,  the  numerator  of which is the Index (as  hereinafter
defined) published nearest but prior to the commencement date of such Adjustment
Period and the denominator of which is the Index published  nearest but prior to
commencement  of  the  twelve  (12)  month  period  immediately  preceding  such
Adjustment  Period,  but  in  no  event  shall  such  fraction,  expressed  as a
percentage, exceed [...***...]%.

         The term iIndexi as used herein shall mean the Consumer Price Index for
All Urban Consumers (1982-84 = 100) San Francisco-Oakland-San  Jose, California,
All Items, published by the Bureau of Labor Statistics of the U.S. Department of
Labor. If the Bureau of Labor  Statistics  ceases to publish the above Index, or
if the above Index is otherwise renamed, discontinued or superseded, the parties
agree that the Bureau of Labor Statistics or any successor  governmental  agency
thereto will be the sole judge of the comparability of successive  indexes,  but
if no succeeding index is published,  the calculations under this Lease based on
the Index  shall be made using the most  closely  comparable  statistics  on the
purchasing power of the consumer dollar as published by a responsible  financial
authority  and  approved  by  Landlord  and  Tenant,  such  approval  not  to be
unreasonably withheld.

5.   Operating Expenses.

         a.  Operating  Expenses.  Commencing as of the Rent  Commencement  Date
applicable to each Phase,  Tenant shall pay Tenant's Percentage Share applicable
to such Phase of Operating  Expenses  incurred by Landlord  during each calendar
year falling in whole or in part during the Term.

         b. Operating Expenses.  The term "Operating Expenses" shall include all
reasonable  expenses  and costs of every kind and nature,  except as provided in
the next paragraph,  which Landlord shall pay or become obligated to pay because
of or in connection with the ownership, management, administration, maintenance,
repair and  operation  of the  Premises,  the  Buildings,  the Common  Areas and
balance of the Property,  to the extent allocable,  as reasonably  determined by
Landlord,  to the  Building  in which the  applicable  Phase of the  Premises is
located.  Operating Expenses shall include,  without limitation,  the following:
(i) all impositions relating to the Property,  including Real Property Taxes (as
defined in

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Section 5.d.); (ii) premiums for insurance  relating to the Property,  including
as set forth in Sections 13.b., 13.d. and 13.i., and insurance  deductibles paid
by Landlord; (iii) wages, salaries, bonuses and expenses and benefits (including
hospitalization,  medical, surgical,  retirement plan, pension plan, union dues,
life  insurance,  including  group  life  insurance,  welfare  and other  fringe
benefits,  and vacation,  holidays and other paid absence benefits, and costs of
uniforms)  of all on-site and off-site  employees of Landlord or its agents,  at
the rank of  property  manager or below (but not above),  engaged in  operation,
management,  administration,  maintenance,  repair  and  security  of  the  Real
Property,   including,  without  limitation,   administrative,   management  and
accounting  personnel and the  individual(s)  responsible  for management of the
Property, and payroll, social security, workersi compensation,  unemployment and
similar taxes with respect to such employees of Landlord or its agents,  and the
cost of providing disability or other benefits imposed by law or otherwise, with
respect to such employees;  (iv) costs of all supplies,  materials and equipment
rentals  used in  operations;  (v) all  maintenance,  janitorial,  security  and
service costs; (vi) a management fee not to exceed [...***...]% of all base rent
revenues  from  the Real  Property  (i.e.  excluding  revenues  attributable  to
Tenant's and other  tenants'  payments of Operating  Expenses);  (vii) legal and
accounting   expenses,   including  the  cost  of  audits  by  certified  public
accountants  relating  to the Real  Property;  (viii) all repair,  painting  and
maintenance  costs  relating to the  Property  and its Common  Areas,  including
sidewalks, landscaping, service areas, mechanical rooms, parking areas, Building
exterior and driveways;  (ix) all charges for heat,  water,  gas,  steam,  fuel,
electricity  and other  utilities  used or consumed in the  Building  and Common
Areas; (x) costs of repairs, replacements, and general maintenance to and of the
Building Systems and the Base Building  Components (as such terms are defined in
Sections  9.a. and 10.a.,  respectively,  below);  and (xi) the costs of capital
improvements,  capital  replacements,  capital repairs,  capital equipment,  and
capital  tools and devices  installed  or paid for by Landlord  and  intended to
reduce other  Operating  Expenses or required to comply with Legal  Requirements
(as defined in Section 8.c.  below) or intended for the protection of the health
and safety of the occupants of the Property.  With respect to any costs included
in  Operating  Expenses  under  clause (x) which are  capital  expenditures,  as
determined  by  Landlord  in  accordance  with  generally  accepted   accounting
principles consistently applied, and with respect to the costs of items included
in Operating  Expenses under clause (xi), such costs shall be amortized over the
useful life of such capital improvement,  equipment, device or other expenditure
(as  reasonably   determined  by  Landlord),   together  with  interest  on  the
unamortized  balance at a rate per annum equal to [...***...]  percentage points
over the Treasury Rate charged at the time such item is constructed or acquired,
or at such higher rate as may have been paid by Landlord on funds  borrowed  for
the purpose of acquiring or constructing  such item, but in either case not more
than the  maximum  rate  permitted  by law at the time such item is  acquired or
constructed.  As used herein,  "Treasury Rate" means the six-month United States
treasury bill rate in effect from time to time by the San Francisco  Main Office
of Bank of America,  NT&SA (or any successor  bank  thereto),  or if there is no
such rate, the rate quoted by such bank in pricing  ninety day commercial  loans
to substantial commercial borrowers.

                  Operating  Expenses  shall  not  include  the  following:  (i)
depreciation  on the  Buildings or, except as provided  above,  amortization  of
equipment or systems therein;  (ii) debt service on any mortgage or similar debt
instrument encumbering the Buildings,  including interest, principal, points and
fees payable thereunder; (iii) rental under any ground or underlying lease; (iv)
attorneys' fees and expenses  incurred in connection with lease  negotiations or
disputes with past,  current or  prospective  tenants of any  Building;  (v) the
cost,  whether  capital  or  otherwise,  of  decorating,  improving  for  tenant
occupancy,  painting or  redecorating  portions of any Building to be demised to
tenants,  including  permit fees or other charges imposed as a condition to such
work; (vi) advertising and promotional  expenditures,  and costs of

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purchase and  installation of signs in or on any Building  identifying the owner
of the Building (except for Building  directories and similar devices which also
identify all tenants  generally);  (vii) costs reimbursed by insurance proceeds,
another  tenant  (other than through the pass through of Operating  Expenses) or
any third party; (viii) real estate broker's or other leasing commissions;  (ix)
capital  expenditures  required to comply with Legal  Requirements  with which a
Building  was  required  to  comply  as of the  date  the  Building's  temporary
certificate  of occupancy or the equivalent  was validly  issued,  or if none is
issued by the  applicable  jurisdiction,  as of the first date  occupancy of the
Building is legally allowed;  (x) except for making repairs or keeping permanent
systems in operation  while  repairs are being made,  rentals and other  related
expenses  incurred  in leasing  air  conditioning  systems,  elevators  or other
equipment ordinarily considered to be of a capital nature (except equipment that
is not  affixed to a Building  which is used in  providing  janitorial  or other
services,  and except to the extent such costs  would  otherwise  be  includable
pursuant  to  items  (x) and  (xi) as set  forth  in the  immediately  preceding
paragraph);  (xi) the cost of services made  available at no special cost to any
tenant of a Building but only made  available to Tenant at special  cost,  (xii)
costs  incurred  due to a  violation  by  Landlord,  as  determined  by  written
admission, stipulation, final judgment or arbitration award, of any of the terms
and  conditions  of any lease  relating to a Building  except to the extent such
costs  reflect  costs that would have been  incurred  by  Landlord  absent  such
violation;  (xiii)  overhead  and  profit  increments  paid  to  Landlord  or to
subsidiaries or affiliates of Landlord for services (other than management) to a
Building  to the extent  that the costs of the  services  materially  exceed the
amounts  normally  payable for similar services to unrelated third parties under
similar  circumstances  (taking into account the market factors in effect on the
date any relevant contracts were negotiated) in comparable business parks within
a ten (10) mile radius of the Property's  perimeter,  excluding San Mateo county
(the  "Comparable  Market");  (xvi) all direct costs of refinancing,  selling or
exchanging  the Building,  including  broker  commissions,  attorney's  fees and
closing  costs;   (xvii)  Landlord's   general  corporate  office  overhead  and
administrative expenses, except for management fees and as otherwise provided in
the preceding paragraph; (xvii) compensation paid to clerks, attendants or other
persons in  restaurants,  garages or other  commercial  concessions  operated by
Landlord unless the services or use thereof, as applicable, are provided free of
separate  charge to tenants of the  Building;  (xviii)  penalties  and  interest
charges  resulting  solely from  Landlord's  failure to pay Real Property  Taxes
prior to  delinquency,  except where  resulting  in whole or part from  Tenant's
failure  to  timely  pay Rent due  under  this  Lease;  (xix)  costs,  fines and
penalties  incurred  due to a violation  by Landlord of any Legal  Requirements,
except to the extent due to a  violation  by Tenant of the terms of this  Lease,
and except  further to the extent such costs  reflect costs that would have been
incurred  by Landlord  absent such  violation;  and (xx) the  purchase  price of
sculptures,  paintings  or other  objects of art  (which  shall not be deemed to
include landscaping or features related thereto) placed in the Common Areas.

                  The parties agree that  statements in this Lease to the effect
that Landlord is to perform certain of its  obligations  hereunder at its own or
sole cost and/or  expense  shall not be  interpreted  as excluding any cost from
Operating Expenses if such cost is an Operating Expense pursuant to the terms of
this Section 5.b.

         c. Monthly Increments;  Adjustment. Promptly following the commencement
of the Term and prior to the  commencement of each subsequent  calendar year (or
as soon  thereafter  as  practicable),  Landlord  shall  estimate the  Operating
Expenses  payable by Tenant for such  calendar  year  pursuant to this  Section.
Commencing as of the Rent  Commencement  Date, and continuing  thereafter of the
first day of each month, Tenant shall pay to Landlord,  in advance,  one-twelfth
(1/12) of Landlord's  estimated  amount. If at any time during the course of the
year Landlord determines that the Operating Expenses payable by Tenant will vary
from the then  estimated  amount,  by notice to Tenant  Landlord  may revise the
amount

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<PAGE>


payable by Tenant  during the balance of the  calendar  year such that the total
estimated  additional  amount due from Tenant for such  calendar year is paid by
Tenant during the balance of the calendar year in equal monthly amounts.  Within
ninety (90) days (or as soon thereafter as practicable)  after the close of each
calendar year, Landlord shall provide Tenant with a statement to account for any
difference  between  the actual and the  estimated  Operating  Expenses  for the
previous year.  Landlord's  annual statement shall be certified by an officer of
Landlord or by Landlord's  independent  accountant and be final and binding upon
Landlord and Tenant unless,  within ninety (90) days after  delivery  thereof to
Tenant,  Landlord  shall  revise or Tenant  shall  contest  any item  therein by
written notice to the other,  specifying  each item revised or contested and the
reason therefor. Notwithstanding the foregoing, the Real Property Taxes included
in any such annual  statement  may be modified by any  subsequent  adjustment or
retroactive  application  of Real Property  Taxes  affecting the  calculation of
Operating  Expenses.  If Tenant has overpaid  the amount of  Operating  Expenses
owing pursuant to this Section,  Landlord shall credit the  overpayment  against
Tenantis  next  payments due under this Section 5. If Tenant has  underpaid  the
amount of Operating  Expenses owing  pursuant to this Section,  Tenant shall pay
the  amount of the  underpayment  to  Landlord  within  thirty  (30) days  after
Tenant's receipt of Landlord's  statement.  If the rentable area of the Building
is not fully  occupied  during any calendar  year,  Operating  Expenses for such
calendar year shall be adjusted to equal Landlord's  reasonable  estimate of the
Operating  Expenses which would have been incurred  during such calendar year if
the total rentable area of the Building were occupied.

         d.  Definition of Real Property  Taxes.  The term "Real Property Taxes"
shall  mean  any  ordinary  or  extraordinary  form  of  assessment  or  special
assessment,  license  fee,  rent tax,  levy,  penalty  (if a result of  Tenant's
delinquency),  or tax (other than net income, estate,  succession,  inheritance,
transfer or  franchise  taxes),  imposed by any  authority  having the direct or
indirect power to tax, or by any city,  county,  state or federal government for
any maintenance or improvement or other district or division  thereof.  The term
shall include all transit charges,  housing fund assessments,  real estate taxes
and all other taxes  relating to the Premises,  Building  and/or  Property,  all
other taxes which may be levied in lieu of real estate taxes,  all  assessments,
assessment bonds, levies,  fees, and other governmental charges (including,  but
not limited to, charges for traffic facilities,  improvements, child care, water
services studies and  improvements,  and fire services studies and improvements)
for amounts  necessary to be expended  because of governmental  orders,  whether
general or special,  ordinary or extraordinary,  unforeseen as well as foreseen,
of any kind and nature for public improvement,  services,  benefits or any other
purposes which are assessed,  levied,  confirmed,  imposed or become a lien upon
the Premises,  Building or Property or become  payable  during the Term.  If, by
law, any Real Property  Taxes (other than amounts which are Tenant's  obligation
pursuant to Section 5.f.  below) could be paid in  installments at the option of
Landlord, then whether or not Landlord elects to pay such Real Property Taxes in
such  installments,  Real  Property  Taxes  (including  any interest  payable on
installments)  shall be computed  as if such  election  had been made,  and only
installments  thereof which would have become due during the given calendar year
shall be included in the calculation of Real Property Taxes for purposed of this
Lease for such calendar year.

         e. Tenant's Audit Rights.  Landlord shall maintain  records  respecting
Operating Expenses in accordance with sound accounting and management practices,
consistently  applied.  Tenant  shall  have  the  right  to  cause  a  reputable
nationally  recognized  accounting  firm to audit  Landlord's  books and records
pertaining  to  Operating  Expenses for the  immediately  prior  calendar  year,
provided  that Tenant  notifies  Landlord in writing of  Tenant's  intention  to
exercise  such audit right within sixty (60) days after  receipt of the relevant
annual  statement  described in Section 5.c.,  actually begins such audit within
thirty (30) days after such notice from Tenant (but in no event earlier than ten
(10)  Business  Days after such  notice) and

                                       6

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diligently  pursues such audit to completion.  Landlord agrees to make available
to Tenant's  auditors,  at the Building or at Landlord's  office in the State of
California,  the books and records relevant to the audit for review and copying,
but such books and records may not be removed from Landlord's  location.  Tenant
shall promptly  deliver to Landlord a copy of the report or other  documentation
prepared by Tenant's  auditors upon  completion of the audit.  Tenant shall bear
all costs of such audit,  except that,  if the audit (as conducted and certified
by  Tenant's   nationally   recognized   accounting  firm)  shows  an  aggregate
overstatement of Operating Expenses of five percent (5%) or more, and Landlord's
auditors concur in such findings (or, in the absence of such  concurrence,  such
overstatement  is  ultimately  confirmed by dispute  resolution),  then Landlord
shall bear  Tenant's  costs of the audit,  such  payment to be made by  Landlord
within  thirty (30) days of Landlord's  receipt of the invoice (with  reasonably
satisfactory  supporting  documentation)  for  such  costs.  If  the  agreed  or
confirmed audit shows an underpayment  of Operating  Expenses by Tenant,  Tenant
shall pay to Landlord,  within  thirty (30) days after the audit is agreed to or
confirmed,  the amount owed to Landlord , and, if the agreed or confirmed  audit
shows an overpayment of Operating  Expenses by Tenant,  Landlord shall reimburse
Tenant for such overpayment within thirty (30) days after the audit is agreed to
or confirmed.

         f. Taxes on Tenant Improvements and Personal Property.  Notwithstanding
any other provision hereof,  Tenant shall pay the full amount of any increase in
Real Property Taxes during the Term resulting from any and all  Alterations  (as
defined  in Section  9.a.  below),  including,  without  limitation,  the Tenant
Improvements, of any kind whatsoever placed in, on or about the Premises for the
benefit  of, at the  request  of,  or by  Tenant.  Tenant  shall  pay,  prior to
delinquency,  all taxes assessed or levied against Tenant's  personal  property,
equipment,  furniture or fixtures (collectively,  iPersonal Propertyi) in, on or
about the Premises.  When possible,  Tenant shall cause its Personal Property to
be  assessed  and  billed  separately  from the  real or  personal  property  of
Landlord.

         g. Fiscal Year.  Landlord  shall have the right to account and bill for
Operating Expenses on the basis of a fiscal year, rather than a calendar year as
set forth above, and to revise such fiscal year from time to time, provided that
Landlord follows generally accepted accounting  principles  consistently applied
in connection therewith.

         h. Net Lease.  This shall be a Net Lease and Base Rent shall be paid to
Landlord  absolutely  net of all costs and expenses  except as expressly  herein
provided.  The provisions for Tenant's  payment of Tenant's  Percentage Share of
Operating  Expenses are intended to pass on to Tenant and reimburse Landlord for
Tenant's  Percentage  Share of all costs and expenses  associated  with the Real
Property, except as expressly provided in this Lease.

6.  Proration of Rent. If any Rent  Commencement  Date is not the first day of a
calendar  month,  or if the end of the Term is not the  last  day of a  calendar
month, Base Rent payable by Tenant pursuant to Section 4, and Operating Expenses
payable by Tenant  pursuant  to Section 5, shall be  prorated  on a daily  basis
(based upon a thirty (30) day month) for such fractional  month. The termination
of this Lease shall not affect the  obligations of Landlord and Tenant  pursuant
to Section 5.c. which are to be performed after the termination.

7. Landlord's Work; Tenant Improvements. Landlord agrees to construct Landlord's
Work  pursuant  to the terms of Exhibit B, and Tenant  agrees to  construct  the
Tenant  Improvements  pursuant to the terms of Exhibit B. Except as set forth in
Exhibit  B, the  Premises  shall be  delivered  to  Tenant  in its then  "as-is"

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condition,  and Landlord  shall not have any  obligation  to make or pay for any
alterations,  additions,  improvements  or repairs to prepare the  Premises  for
Tenantis occupancy.

8. Use of the Premises.

         a. Use. The Premises  shall be used solely for the use set forth in the
Basic Lease Information and for no other use or purpose.  Landlord  acknowledges
that such use may  include  [...***...].  Tenant  shall not  unreasonably  do or
suffer or permit  anything to be done in or about the  Premises or the  Property
which will in any way obstruct or interfere  with the rights of other tenants or
occupants of the  Buildings or injure or annoy them,  or use or suffer or permit
the Premises to be used for any immoral,  unlawful or objectionable purpose, nor
shall Tenant cause, maintain,  suffer or permit any nuisance in, on or about the
Premises or the Real Property. Without limiting the foregoing,  Tenant shall not
permit any odors,  smoke,  dust,  gas or other  substances  to emanate  from the
Premises except in accordance with all applicable  Legal  Requirements and sound
environmental practices and through such devices and in such manner as shall not
interfere  with the use of the  Property  by other  tenants or  permitted  users
thereof or cause any damage to the Premises or the balance of the Property,  and
as Landlord shall have approved in writing, such approval not to be unreasonably
withheld,  nor shall  Tenant  permit any noise or  vibration to emanate from the
Premises without the prior written approval of Landlord,  and no loudspeakers or
other similar device which can be heard outside the Premises shall,  without the
prior written  approval of Landlord,  be used in or about the  Premises.  Tenant
shall  not  commit  or  suffer  to be  committed  any  waste in, to or about the
Premises.  Tenant agrees not to employ any person,  entity or contractor for any
work in the Premises  (including  moving Tenant's  equipment and furnishings in,
out or around the  Premises)  whose  presence  may give rise to a labor or other
disturbance in the Building and, if necessary to prevent such a disturbance in a
particular situation,  Landlord may require Tenant to employ union labor for the
work.

         b. Rules and  Regulations;  CC&R's.  Tenant shall comply with the Rules
and  Regulations  attached hereto as Exhibit D, as the same may be modified from
time to time by Landlord upon prior notice to Tenant (the "Rules"). In addition,
Tenant shall comply with any covenants,  conditions and restrictions  ("CC&R's")
applicable to the Real Property,  and all rules,  regulations  and  restrictions
imposed by any association  formed  pursuant to the CC&R's,  in each case to the
extent  Landlord has  delivered a copy thereof to Tenant and the same are not in
conflict with the provisions of this Lease.

         c.  Compliance.  Tenant  shall not  permit the  Premises  to be used in
violation  of or in  conflict  with,  and at its  sole  cost and  expense  shall
promptly comply with, all laws,  statutes,  ordinances and  governmental  rules,
regulations or requirements  now in force or which  hereinafter may be in force,
with the  requirements of any board of fire  underwriters or other similar board
now or hereafter constituted, with any direction or occupancy certificate issued
pursuant to any law by any public officer or officers, as well as the provisions
of all  recorded  documents  affecting  the  Premises  (all  of  the  foregoing,
collectively, "Legal Requirements"),  insofar as any thereof relate to or affect
the  condition,  use or occupancy of the Premises,  and Tenant shall perform all
work to the Premises and other portions of the Property  required to effect such
compliance  (or, at  Landlordis  election,  Landlord  may  perform  such work at
Tenantis expense).  The judgement of any court of competent  jurisdiction or the
admission of Tenant in any actions against Tenant,  whether  Landlord be a party
thereto or not,  that Tenant has so violated any such law,  statute,  ordinance,
rule,  regulation  or  requirement,  shall be  conclusive  of such  violation as
between Landlord or Tenant.

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         d. Hazardous  Materials.  Tenant shall not cause or permit the storage,
use, generation, release, handling or disposal (collectively, "Handling") of any
Hazardous  Materials  (as defined  below),  in, on, or about the Premises or the
Property by Tenant or any agents, employees, contractors, licensees, subtenants,
customers,  guests or  invitees of Tenant  (collectively  with  Tenant,  "Tenant
Parties"), except that Tenant shall be permitted to use in the Premises (i) in a
normal and  customary  manner normal  quantities of office  supplies or products
(such as copier fluids or cleaning supplies)  customarily used in the conduct of
general business office activities  ("Common Office  Chemicals"),  and (ii) in a
manner  reasonably  required  by  Tenant's  permitted  use of the  Premises  the
Hazardous  Materials  customarily  used in a Group B Occupancy under the Uniform
Building Code ("Excepted  Hazardous  Materials");  provided that the Handling of
such Common Office  Chemicals and Excepted  Hazardous  Materials shall comply at
all times with all Legal  Requirements,  including  Hazardous Materials Laws (as
defined below).  In addition,  with  Landlord's  prior written  approval,  which
approval shall not be unreasonably withheld, Tenant shall be permitted to use in
the Premises  such other  Hazardous  Materials as may be necessary in connection
with the conduct of Tenant's permitted business upon the Premises,  provided the
Handling of such  Hazardous  Materials  shall comply at all times with all Legal
Requirements,  including  Hazardous Materials Laws. In no event shall Landlord's
approval  requested  pursuant to the preceding  sentence be deemed  unreasonably
withheld if Landlord shall (x) determine in good faith that Tenant's use of such
Hazardous Materials would present an unreasonable threat of contamination of the
Premises or any other portion of the Property,  (y) determine in good faith that
Tenant's use of such  Hazardous  Materials  would violate the  provisions of any
other  lease or any ground  lease or  underlying  lease,  or mortgage or deed of
trust, affecting the Property or any portion thereof , or interfere with the use
and  occupancy of any other portion of the Building or the Property by any other
tenant or permitted  occupant thereof (except that in no event shall this clause
(y) preclude Tenant from using Excepted Hazardous  Materials),  or (z) condition
the  effectiveness  thereof upon Tenant's  delivery to Landlord of evidence that
Tenant  has  obtained  all  governmental  permits  and  approvals  necessary  in
connection  with Tenant's  Handling of such Hazardous  Materials,  together with
copies of all such permits and approvals.  Upon Landlord's  request from time to
time,  Tenant  shall  provide to Landlord a complete  written  inventory  of all
Hazardous Materials which Tenant anticipates using or storing on, or discharging
from , the Premises along with copies of all reports, permits and business plans
filed with any federal,  state, local or other governmental agency. Tenant shall
update the inventory as  frequently as required to reflect any material  changes
to  the  items  required  to  be  disclosed  therein.  Tenant  shall  be  solely
responsible  for and shall  indemnify,  defend and hold  Landlord  and all other
Indemnitees (as defined in Section 13.a.  below),  harmless from and against all
Claims (as defined in Section  13.a.  below),  arising  out of or in  connection
with,  or otherwise  relating to (i) any Handling of Hazardous  Materials by any
Tenant  Party or  Tenant's  breach  of its  obligations  hereunder,  or (ii) any
removal,  cleanup,  or  restoration  work and materials  necessary to return the
Property or any other  property of whatever  nature  located on the  Property to
their condition existing prior to the Handling of Hazardous  Materials in, on or
about the Premises by any Tenant Party.  Tenant shall promptly  provide Landlord
with copies of all notices received by it, including,  without  limitation,  any
notice of  violations,  notice of  responsibility  or demand for action from any
federal, state or local authority or official in connection with the presence of
Hazardous  Materials  in or about  the  Premises  or any  other  portion  of the
Property.  In the event of any release of Hazardous  Materials upon the Premises
or any other  portion of the  Property,  or upon  adjacent  lands,  if caused by
Tenant or any other Tenant Party,  Tenant shall  promptly  remedy the problem in
accordance with all applicable Legal  Requirements.  For purposes of this Lease,
"Hazardous  Materials"  means any explosive,  radioactive  materials,  hazardous
wastes,  or  hazardous   substances,   including  without  limitation   asbestos
containing  materials,   PCB's,  CFC's,  or  substances  defined  as  "hazardous
substances"  in  the  Comprehensive  Environmental  Response,  Compensation  and
Liability Act of 1980, as amended,  42 U.S.C.  Section 9601-9657;  the Hazardous
Materials  Transportation

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<PAGE>


Act of 1975, 49 U.S.C. Section 1801-1812; the Resource Conservation and Recovery
Act of 1976,  42  U.S.C.  Section  6901-6987;  or any  other  Legal  Requirement
regulating,   relating  to,  or  imposing  liability  or  standards  of  conduct
concerning  any such  materials or  substances  now or at any time  hereafter in
effect  (collectively,  "Hazardous  Materials  Laws").  The  provisions  of this
Section 8.d. shall survive the expiration or earlier termination of this Lease.

9.   Alterations.

         a.  Alterations.  Tenant shall not make any  Alterations (as defined in
Section  9.e.  below)  in, to or upon the  Premises  without  the prior  written
consent of Landlord in each  instance,  which consent shall not be  unreasonably
withheld with respect to proposed  Alterations  which (i) are not  structural in
nature,  (ii)  do not  affect  the  Base  Building  Components,  (iii)  are,  in
Landlord's opinion, compatible with the Building in which the applicable portion
of the Premises is located and the balance of the Property,  and the  Building's
mechanical,   plumbing,   electrical,    heating/ventilation/air   conditioning,
communication,  security and fire and other life safety  systems  (collectively,
the "Building Systems"),  and (iv) in Landlord's opinion will not interfere with
the use and  occupancy  of any other  portion of the Building or the Property by
any other tenant or permitted  occupant thereof.  Tenant shall give Landlord not
less than ten (10) days' prior written notice of any Alterations  Tenant desires
to make.  Any  Alterations as to which Landlord shall consent shall be made only
by contractors approved in advance, in writing by Landlord, which approval shall
not be unreasonably withheld;  provided, however, that Landlord may, in its sole
discretion,  specify the engineers and  contractors to perform any work relating
to or affecting  the Building  Systems or the Base Building  Components.  Tenant
shall comply with all Legal  Requirements  applicable  to each  Alteration  and,
except as to Cosmetic Alterations (as defined below) shall deliver to Landlord a
complete set of "as built" plans and  specifications  for each  Alteration.  Any
work to the balance of the Building or Property  (required by Legal Requirements
or otherwise) related to or affected or triggered by Tenantis  Alterations shall
be performed by Tenant at Tenantis expense (or, at Landlordis election, Landlord
may perform such work at Tenantis  expense).  Tenant shall be solely responsible
for maintenance and repair of all Alterations  made by Tenant.  Tenant shall pay
Landlord on demand  (whether prior to or during the course of  construction ) an
amount (the  "Alterations  Fee") equal to  [...***...] of the total cost of each
Alteration (and for purposes of calculating the Alterations Fee, such cost shall
include  architectural  and engineering fees, but shall not include permit fees)
up to a total  cost of  $[...***...],  and  [...***...]  of such total cost over
$[...***...],  as compensation to Landlord for  miscellaneous  costs incurred by
Landlord  in  connection  with  the  Alteration;   provided,  however,  that  no
Alterations  Fee  shall  be  payable  for  Cosmetic  Alterations  or the  Tenant
Improvements.  In  addition,  except as to Cosmetic  Alterations,  Tenant  shall
reimburse  Landlord  for all  reasonable  third  party fees paid by  Landlord in
connection with reviewing the proposed  Alterations (whether or not the proposed
Alterations are ultimately  approved by Landlord or made by Tenant),  including,
without   limitation,   Landlord's   architectural  and  engineering  fees.  All
Alterations  shall be  performed  diligently  and in a  first-class  workmanlike
manner and in accordance with plans and specifications approved by Landlord, and
shall comply with all Legal Requirements and Landlord's  construction procedures
and requirements for the Building (including Landlord's requirements relating to
insurance and contractor qualifications and scheduling of the work).

         Notwithstanding  the  foregoing,  Tenant shall have the right,  without
Landlord's  consent,  to make any Alteration to the Premises,  provided that the
Alteration  (a) is decorative in nature (such as paint,  carpet or other wall or
floor  finishes,  partitions  or other such work),  (b) does not affect the Base
Building

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Components or the Building Systems, (c) is not structural in nature and does not
require a building permit or other  governmental  permit,  uses only first-class
materials and is performed in a workman-like  manner and in accordance  with all
applicable Legal  Requirements,  and (d) does not cost in excess of [...***...].
Any Alteration  permitted without  Landlord's consent pursuant to this paragraph
is referred to in this Lease as a "Cosmetic Alteration".

         b.  Liens.  If,  because  of any act or  omission  of  Tenant or anyone
claiming by,  through,  or under Tenant,  any  mechanic's  lien or other lien is
filed against the Premises or any other portion of the Property or against other
property of Landlord  (whether or not the lien is valid or enforceable),  Tenant
shall,  at its own  expense,  cause  it to be  discharged  of  record  within  a
reasonable time, not to exceed ten (10) days,  after the date of the filing.  In
addition,  Tenant shall defend and indemnify  Landlord and hold it harmless from
any and all Claims  resulting  from the lien.  Without  limitation of Landlordis
other  remedies,  Landlord  shall have the rights under  Section 16 below if any
such lien is not timely discharged by Tenant.

         c. Ownership of Alterations. All Alterations shall be Tenant's property
during the term of this Lease.  All  Alterations,  once completed,  shall not be
altered or removed from the Premises  without  Landlord's prior written approval
pursuant to Section  9.a.  above,  except  that Tenant may remove any  Removable
Trade  Fixtures (as defined in Section 9.e.  below) without  Landlord's  consent
provided  that Tenant  repairs any damage to the  Premises or the Real  Property
caused by such removal.  Without  limitation,  Landlord's  approval  pursuant to
Section  9.a.  above  shall  not be  deemed  unreasonably  withheld  if any such
Alterations  would be  removed,  altered or  demolished  and not  replaced  with
Alterations  of equal or greater  value and of the same utility and character as
the prior Alterations. Upon the expiration or earlier termination of this Lease,
all Alterations (other than Removable Trade Fixtures,  which shall be and at all
times remain Tenant's property) shall immediately and automatically, without any
required  action  or  notice by  Landlord  or  Tenant,  become  Landlord's  sole
property,  without  any  obligation  on Landlord to pay Tenant any sums or other
consideration  therefor.  Tenant shall not finance any  Alterations by any means
whatsoever which would result in a lien or security  interest thereon or therein
in favor of any party,  nor shall  Tenant  otherwise  allow any lien or security
interest to be imposed upon or attach to any Alterations.  Except as provided in
Section 9.d. and below in this Section  9.c.,  Landlord may require  Tenant,  at
Tenant's sole expense and by the end of the Term, to remove any  Alterations and
to  restore  the   Premises  to  its   condition   prior  to  the   Alterations.
Notwithstanding the preceding  sentence,  Tenant shall not be required to remove
any of the Tenant  Improvements  (other than  Removable  Trade  Fixtures) to any
portion of the Premises improved as general office space or warehouse space, and
nor shall  Tenant be  required to remove any of the Tenant  Improvements  (other
than Removable Trade  Fixtures) to any portion of the Phase I Premises  improved
as laboratory  space if no more than  [...***...] of the rentable square footage
of the Phase I Premises is improved as laboratory space, and nor shall Tenant be
required to remove any of the Tenant  Improvements  (other than Removable  Trade
Fixtures) to any portion of the Phase II Premises  improved as laboratory  space
if no more than  [...***...]  of the  rentable  square  footage  of the Phase II
Premises is improved as laboratory space.

         d.  Request  Regarding  Removal  Obligation.  At the time  that  Tenant
requests Landlord's consent to any Alteration,  Tenant may request that Landlord
notify Tenant if Landlord  will require  Tenant,  at Tenant's  sole expense,  to
remove any or all of the  Alteration by the end of the Term,  and to restore the
Premises to its condition  prior to the  Alteration.  Unless Landlord shall have
expressly  agreed

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in writing not to require  such  removal and  restoration,  Landlordis  election
right under Section 9.c. shall  continue  through the end of the Term as to such
Alterations.

         e.  Definitions.  The term  "Alterations"  shall mean any  alterations,
additions  or   improvements,   including,   without   limitation,   the  Tenant
Improvements constructed by Tenant pursuant to Exhibit B attached hereto (except
that in the event of any  conflict  between the terms of Exhibit B and the terms
of this Section 9 (or the balance of this  Lease),  the terms of Exhibit B shall
control), Built-In Trade Fixtures, and Removable Trade Fixtures, except that any
Removable  Trade  Fixtures  which  are  Portable  Equipment  shall not be deemed
"Alterations".

                  The term "Built-In Trade Fixtures" shall mean [...***...].

                  The term "Removable  Trade  Fixtures"  shall mean  [...***...]
except  that in no event  shall  "Removable  Trade  Fixtures"  include any items
described  above in the  definition  of "Built-In  Trade  Fixtures" or described
below in the definition of "Base Improvements".

                  The term "Portable Equipment" means [...***...].

                  The term "Base Improvements" means [...***...].

10.  Repairs.

         a. Landlord's Repairs.  Landlord shall maintain the roof,  foundations,
floor slabs and exterior walls of the Building (collectively, the "Base Building
Components")  in good condition and repair,  reasonable  wear and tear excepted.
The term walls as used herein shall not include  windows,  glass or plate glass,
doors,  special  store  fronts or office  entries.  The term roof as used herein
shall not include  skylights,  smoke hatches or roof vents.  Landlord shall also
maintain in good condition and repair,  reasonable  wear and tear excepted,  the
Common Areas, including, but not limited to, the landscaped areas, parking areas
and driveways. Tenant shall reimburse Landlord for Landlord's costs of complying
with its  obligations  under this Section 10 in accordance with Section 5 above,
provided,  however, that any damage caused by or repairs necessitated by any act
of Tenant or any other  Tenant  Party may be repaired by Landlord at  Landlord's
option and at Tenant's expense. Tenant shall give Landlord prompt written notice
of any repairs  required of Landlord  pursuant to this  Section 10,  after which
notice Landlord shall have reasonable opportunity to perform the same.

                  Landlord  shall also repair any patent  defects in  Landlord's
Work in each Phase of the Premises  provided that Tenant gives  Landlord  notice
thereof within three (3) months  following the  Commencement  Date applicable to
such Phase. Landlord shall also repair latent defects in Landlord's Work in each
Phase of the Premises,  provided  Tenant gives  Landlord  notice  thereof within
thirty (30) days after the date that Tenant discovers the same, but in any event
within two (2) years following the Commencement Date applicable to such Phase.

         b. Tenant's Repairs.  Tenant shall, at Tenant's  expense,  maintain all
parts of the Premises in a good, clean and secure condition, promptly making all
necessary repairs and replacements  including,  but not limited to, all windows,
glass or plate  glass,  doors and any special  store  fronts or office  entries,
walls and wall finishes,  floor covering,  Building  Systems,  truck doors, dock
bumpers,  dock plates and  levelers,  plumbing  work and  fixtures,  downspouts,
skylights,  smoke hatches, roof vents and utility equipment, in

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each case to the extent the same are  located  within or  exclusively  serve the
Premises.  Tenant  shall,  at Tenant's  expense,  also  perform  necessary  pest
extermination and regular removal of trash and debris. Tenant shall, at Tenant's
expense,  enter  into  a  regularly  scheduled  preventive   maintenance/service
contract with a maintenance  contractor for servicing all hot water, heating and
air  conditioning  systems and  equipment  within or serving the  Premises,  and
provide  Landlord with copies of all such  contracts  upon  Landlord's  request.
Tenant shall not damage any demising  wall or disturb the  integrity and support
provided by any demising wall and shall, at its sole expense, immediately repair
any damage to any  demising  wall caused by Tenant or its  employees,  agents or
invitees  or any other  Tenant  Party.  Tenant  hereby  waives all right to make
repairs at the expense of Landlord or in lieu thereof to vacate the Premises and
its other similar rights as provided in California Civil Code Sections  1932(1),
1941 and 1942 or any  other  Legal  Requirement  (whether  now or  hereafter  in
effect).  Notwithstanding the foregoing, Tenant shall not be required to perform
any repairs which are required to be performed by Landlord  under Section 10.a.,
or are required by reason of Landlord's gross negligence or willful misconduct.

         c. Rent Abatement.  In the event that Landlord fails to repair the Base
Building  Components  as  required  hereunder,  and such  failure  is not due to
strikes, lock-outs, labor disputes,  shortages of material or labor, fire, flood
or other casualty,  inclement weather (including rainfall) or adverse conditions
resulting  therefrom,  acts of God or any  other  cause  (other  than  financial
inability) beyond the reasonable control of Landlord ("Force Majeure"), and such
repair  is not  necessitated  by the acts or  omissions  of  Tenant or any other
Tenant  Party,  and as a result of such failure by Landlord  Tenant is unable to
conduct and does not conduct its business in all or a substantial portion of the
Premises for a period of [...***...] or more consecutive days, the Base Rent and
Operating  Expenses  shall be  abated  commencing  with the  expiration  of such
[...***...]  day period,  based upon the area of the  Premises  which  Tenant is
unable to use and does not use for the  conduct of its  business  as a result of
such failure by Landlord, and continuing until the earlier of the making of such
repair or the use of such  portion of the  Premises by Tenant for the conduct of
its business.

11.  Damage or Destruction.

         a.  Landlord's  Obligation  to Rebuild.  If the Premises are damaged or
destroyed,  Landlord  shall  promptly  and  diligently  repair the  Premises  as
described in Section  11.c.  below  unless  Landlord has the option to terminate
this Lease as provided herein, and Landlord elects to terminate.

         b. Right to Terminate. Landlord shall have the option to terminate this
Lease if the  Premises or any  Building in which any portion of the  Premises is
located is destroyed or damaged by fire or other casualty, regardless of whether
the  casualty  is insured  against  under this  Lease,  if  Landlord  reasonably
estimates that the repair of the Premises or such Building,  in each case to the
extent of Landlord's  Work,  cannot be completed  within  [...***...]  after the
casualty.  Landlord  shall  also have the right to  terminate  this Lease if the
repair  of the  Premises  or of the  Building,  in each  case to the  extent  of
Landlord's Work, is not fully covered by insurance maintained (or required to be
maintained)  by the Landlord  pursuant to this Lease other than by reason of the
deductible amounts under Landlordis  insurance  policies.  Tenant shall have the
option to  terminate  this Lease if the Premises is damaged or destroyed by fire
or other  casualty,  and Landlord  reasonably  estimates  that the repair of the
Premises,  to  the  extent  of  Landlord's  Work,  cannot  be  completed  within
[...***...]  after the  casualty.  Landlord  shall notify  Tenant of  Landlordis
reasonable  repair period  estimate  within (60) days after the  casualty.  If a
party  desires to exercise  the right to  terminate  this Lease as a result of a
casualty,  the party shall  exercise the right by giving the other party

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written  notice of its  election  to  terminate  within  thirty  (30) days after
delivery of Landlordis  repair period estimate,  in which event this Lease shall
terminate fifteen (15) days after the date of the terminating partyis notice. If
neither  Landlord nor Tenant  exercises the right to terminate this Lease,  this
Lease  shall  continue  in full  force and effect and  Landlord  shall  promptly
commence the process of obtaining  necessary  permits and  approvals,  and shall
commence  repair of the  Premises  or the  Building as soon as  practicable  and
thereafter prosecute the repair diligently to completion.

         c. Limited Obligation to Repair. Landlord's obligation, should Landlord
elect or be  obligated  to  repair  or  rebuild,  shall be  limited  to the Base
Building Components and the other components of Landlord's Work. Unless Landlord
or Tenant terminates this Lease as permitted hereunder,  Tenant, at its expense,
shall replace or fully repair all Alterations, including the Tenant Improvements
and Built-in Trade Fixtures, but excluding, at Tenant's option,  Removable Trade
Fixtures, existing at the time of the damage or destruction.  Unless Landlord or
Tenant terminates this Lease as permitted hereunder,  and so long as no Event of
Default shall have occurred and be continuing hereunder, Landlord shall make the
proceeds paid to Landlord from the  insurance  maintained by Tenant  pursuant to
Section 13.h. below (the "Tenant Improvement  Insurance  Proceeds") available to
Tenant for such replacement and repair. Such amounts shall be disbursed pursuant
to the  procedures  set forth in  Exhibit B  attached  hereto  with  respect  to
Landlord's  Contribution,  except that the frequency of such disbursements shall
be every  thirty  (30)  days or such  longer  intervals  as Tenant  may  request
(subject,  in any event,  to the conditions for  disbursement  set forth in said
Exhibit  B). If either  Landlord  or Tenant  terminates  this Lease  pursuant to
Section  11.b.,  and so long as no Event of Default shall have occurred and been
continuing at the time of such termination, Landlord shall pay to Tenant, within
thirty  (30) days after the  termination  date (or such  later date as  Landlord
receives the Tenant Improvement  Insurance Proceeds),  the portion of the Tenant
Improvement Insurance Proceeds in [...***...],  including the Base Improvements,
Built-In  Trade  Fixtures,  and other Tenant  Improvements,  but  excluding  the
Removable Trade Fixtures (since the Tenant  Improvement  Insurance Proceeds will
not include any amount  attributable to the Removable Trade Fixtures),  provided
that Tenant shall have furnished to Landlord,  within ninety (90) days after the
Rent  Commencement  Date  applicable to each Phase of the  Premises,  a detailed
accounting of such costs paid by Tenant in such Phase of the  Premises,  such as
receipts and construction invoices.

         d.  Abatement of Rent. In the event of any damage or destruction to the
Premises which does not result in  termination of this Lease,  the Base Rent and
Operating Expenses shall be temporarily abated proportionately to the degree the
Premises are  untenantable as a result of the damage or destruction,  commencing
from the date of the  damage or  destruction  and  continuing  during the period
required by Landlord to substantially complete its repair and restoration of the
Premises to the extent of  Landlord's  Work;  provided,  however,  that  nothing
herein shall preclude Landlord from being entitled to collect the full amount of
any  rent  loss  insurance  proceeds.  Tenant  shall  not  be  entitled  to  any
compensation  or  damages  from  Landlord  for loss of the use of the  Premises,
damage to Tenant's  Personal  Property or any  inconvenience  occasioned  by any
damage,  repair or  restoration.  Tenant hereby waives the provisions of Section
1932, Subdivision 2, and Section 1933, Subdivision 4, and Sections 1941 and 1942
of  the  California  Civil  Code,  and  the  provisions  of  any  similar  Legal
Requirement (whether now or hereafter in effect).

         e. Insurance Proceeds. Subject to Section 11.c. above, if this Lease is
terminated,  Landlord may keep all the  insurance  proceeds  resulting  from the
damage  payable  to  Landlord  pursuant  to  insurance

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coverage  maintained  by  Landlord,  or  maintained  by Tenant  and under  which
Landlord is loss payee  pursuant to the foregoing  provisions,  and Tenant shall
have no claims thereto.

12. Eminent  Domain.  If all or any material part of the Premises or the balance
of the  Property  is taken for  public  or  quasi-public  use by a  governmental
authority  under the power of eminent  domain or is conveyed  to a  governmental
authority in lieu of such taking (a itakingi), Landlord may terminate this Lease
by written notice to Tenant within thirty (30) days after the taking.  If all or
any material  part of the Premises or the balance of the Property is taken,  and
if the taking causes the remaining  part of the Premises to be  untenantable  or
inaccessible,  and  inadequate  for use by Tenant for the purpose for which they
were leased,  then Tenant, at its option and by giving notice within thirty (30)
days  after  the  taking,  may  terminate  this  Lease as of the date  Tenant is
required to surrender  possession of the Premises or the date such other portion
of the Property is taken,  as  applicable.  If part of the Premises is taken but
the remaining part is tenantable and accessible,  and adequate for Tenant's use,
then this Lease shall be  terminated  as to the part taken as of the date Tenant
is required to surrender possession,  and, unless Landlord shall have terminated
this  Lease  pursuant  to the  foregoing  provisions,  Landlord  shall make such
repairs, alterations and improvements as may be necessary to render the part not
taken  tenantable,  and the Base Rent shall be reduced in proportion to the part
of the  Premises  taken.  All  compensation  awarded for the taking shall be the
property of Landlord  without any deduction  therefrom for any estate of Tenant,
and Tenant hereby  assigns to Landlord all its right,  title and interest in and
to the  award.  Tenant  shall  have the  right,  however,  to  recover  from the
governmental  authority,  but not from  Landlord,  such  compensation  as may be
awarded to Tenant on account of the  interruption of Tenant's  business,  moving
and relocation expenses, removal of Tenant's Personal Property, and the value of
the Tenant Improvements,  Built-In Trade Fixtures,  Removable Trade Fixtures and
other Alterations in Tenant's  proportionate  share,  based on the proportionate
share of costs for such items paid by  Tenant,  provided  that any such award to
Tenant will not reduce the award which would otherwise be made to Landlord.

13.  Indemnity and Insurance.

         a.   Indemnity.   Tenant  shall  hold  Landlord  and  its   constituent
shareholders,  partners,  members  or other  owners,  and all of  their  agents,
contractors,  officers, directors and employees (collectively with Landlord, the
"Indemnitees")  harmless from and indemnify the Indemnitees  against any and all
claims,   liabilities,   damages,  costs  and  expenses,   including  reasonable
attorneys' fees and costs incurred in defending against the same  (collectively,
"Claims"),  to the extent arising from (a) the acts or omissions of Tenantor any
other Tenant Party in, on or about the Real Property, or (b) any construction or
other work  undertaken  by or on behalf of Tenant in, on or about the  Premises,
whether  prior to or during  the Term,  other than any such work  undertaken  by
Landlord,  or (c) any  accident,  injury or damage,  howsoever and by whomsoever
caused,  to any  person or  property,  occurring  in, on or about the  Premises;
except to the extent such Claims are caused directly by the gross  negligence or
willful  misconduct  of the party  seeking  the benefit of such  indemnity  from
Tenant.  In  case  any  action  or  proceeding  be  brought  against  any of the
Indemnitees  by reason of any such Claim,  Tenant,  upon  notice from  Landlord,
covenants  to  resist  and  defend  at  Tenant's  sole  expense  such  action or
proceeding  by counsel  reasonably  satisfactory  to Landlord  and  Tenant.  The
provisions  of this  Section  13.a.  shall  survive  the  expiration  or earlier
termination of this Lease with respect to any injury,  illness,  death or damage
occurring prior to such expiration or termination.

         b. Fire and Extended  Coverage.  Landlord shall procure and maintain in
full force and effect with respect to the  Buildings a policy or policies of all
risk insurance (including sprinkler,  vandalism and malicious mischief coverage,
and any other endorsements  desired by the Landlord or required by the

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holder of any fee or leasehold mortgage on the Real Property, but excluding,  at
Landlordis option, the insurance  described in Section 13.i. below) in an amount
equal to [...***...] of the full replacement cost (including debris removal, and
demolition,   but  excluding  the  land  and  the  footings,   foundations   and
installations below the basement level) of Landlord's Work. Such insurance,  and
all other  insurance  maintained by Landlord under this Lease,  shall be for the
sole benefit of Landlord,  and the proceeds  therefrom shall be under Landlordis
sole control.

         c. Public Liability,  Etc.. Tenant, at its own cost and expense,  shall
keep and  maintain  in full  force  and  effect  during  the Term the  following
insurance   coverages,   written  by  an   insurance   company  with  a  general
policyholders'  rating of "A" or better and a financial  size  ranking of "Class
VIII" or higher,  in the most recent edition of Best's  Insurance  Guide, in the
form customary to the locality,  (i)  commercial  general  liability  insurance,
including  contractual  liability  coverage,  insuring Tenant's  activities with
respect to the Premises  and/or the Building  against loss,  damage or liability
for  personal  injury  or death of any  person  or loss or  damage  to  property
occurring  in, upon or about the Premises,  with a minimum limit of  [...***...]
per  occurrence/general  aggregate,  plus a [...***...]  per  occurrence/general
aggregate   umbrella,   (ii)  fire  damage   legal   liability   insurance   and
personal/advertising   injury   insurance,   each  in  the  minimum   amount  of
[...***...],  (iii) worker's  compensation  insurance in statutory amounts,  and
(iv) if Tenant  operates  owned,  leased or non-owned  vehicles on the Property,
comprehensive   automobile   liability   insurance   with  a  minimum  limit  of
$[...***...] per occurrence;  provided, however, that if, at any time during the
Term,  Tenant  shall have in full  force and  effect a blanket  policy of public
liability  insurance with the same coverage for the Premises as described above,
as well as coverage of other  premises  and  properties  of Tenant,  or in which
Tenant has some interest,  the blanket  insurance  shall satisfy the requirement
hereof and be endorsed to separately apply to the Premises.

         d. Rental Abatement  Insurance.  Landlord may keep and maintain in full
force and effect during the Term rental abatement insurance against abatement or
loss of rents with  respect to the  Property  in such  amount as  determined  by
Landlord.

         e.  Insurance  Certificates.  Tenant shall  furnish to Landlord,  on or
before the Commencement Date and thereafter within thirty (30) days prior to the
expiration  of each  policy,  and from time to time on at least  ten (10)  days'
prior written request from Landlord, an original certificate of insurance issued
by the insurance  carrier of each policy of insurance carried by Tenant pursuant
to this Section 13. The certificates  shall expressly  provide that the policies
shall not be cancelable  except after thirty (30) days' prior written  notice to
the parties named as insureds.  In addition,  Tenant shall give Landlord written
notice  of any  change  in  coverage  at least  thirty  (30)  days  prior to the
effective  date of such change,  but no such change in coverage shall render the
policies in noncompliance with the requirements hereof. Landlord, its successors
and assigns,  and any nominee of Landlord  holding any interest in the Premises,
including,  without  limitation,  any ground  lessor or the holder of any fee or
leasehold mortgage, shall be named as an additional insured under each policy of
insurance  maintained  by  Tenant  pursuant  to this  Lease.  The  policies  and
certificates shall further provide that the coverage shall be primary,  and that
any coverage  carried by Landlord  shall be secondary and  noncontributory  with
respect to Tenantis policy.

         f. Tenant's Failure. If Tenant fails to maintain any insurance required
by this Lease,  Tenant shall be liable for any loss or cost  resulting  from the
failure.  This Section  shall not be deemed to be a waiver of any of  Landlord's
rights and remedies under any other provision of this Lease.

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         g. Waiver of  Subrogation.  Any policy or  policies  of fire,  extended
coverage or similar casualty  insurance which either party obtains in connection
with the Building,  the Premises,  or Tenant's Personal Property shall include a
clause or endorsement  denying the insurer any rights of subrogation against the
other party to the extent  rights  have been waived by the insured  prior to the
occurrence  of injury or loss.  Landlord  and Tenant  each  waives any rights of
recovery  against  the other for injury or loss due to  hazards  covered by such
insurance  policies,  regardless of whether such insurance  policies or coverage
shall  actually  have been  obtained  by the party  granting  such  waiver,  and
regardless  of the  cause  of  such  fire  or  casualty,  including  the  act or
negligence of the party  benefiting from such waiver.  Because this Section 13.g
will preclude the assignment of any claim  mentioned in it by way of subrogation
or  otherwise to an insurance  company or any other  person,  each party to this
Lease agrees  immediately  to give to each of its  insurance  companies  written
notice of the terms of the mutual waivers  contained in this Section 13.g and to
have the insurance  policies  properly  endorsed,  if necessary,  to prevent the
invalidation  of  the  insurance  coverages  by  reason  of the  mutual  waivers
contained in this Section 13.g.

         h.  Tenant's  Property  and  Fixtures.  Tenant shall assume the risk of
damage to any of Tenantis furniture,  equipment,  machinery,  goods, supplies or
fixtures or other Personal Property (including the Portable  Equipment),  and to
any  Alterations  which  Tenant  may make to the  Premises  (including  the Base
Improvements, Built-In Trade Fixtures, Removable Trade Fixtures and other Tenant
Improvements),  and shall insure the same  throughout  the Term,  for their full
replacement cost, under insurance policies  reasonably  satisfactory to Landlord
(certificates  of which  shall be  delivered  to  Landlord as set forth above in
Section 13.e). Tenant hereby releases Landlord from any obligation to insure the
foregoing  items and from any  liability  for loss of or  damage to such  items,
regardless  of  cause.  Landlord  shall  be  named  the  loss  payee of all such
insurance  covering  Alterations other than Removable Trade Fixtures,  provided,
however,  that  Landlord  shall be obligated to disburse  proceeds from any such
insurance to the extent  required by and in  accordance  with the  provisions of
Section 11 above.  Landlord  shall not be the loss  payee on any such  insurance
covering the Portable Equipment.

         i. Earthquake and Flood  Insurance.  In addition to any other insurance
policies carried by Landlord in connection with the Building, Landlord may elect
to procure and maintain in full force and effect during the Term with respect to
the Building a policy of  earthquake/volcanic  action and flood  and/or  surface
water insurance,  including rental value insurance  against abatement or loss of
rent in the case of damage or loss  covered  under the  earthquake/volcanic  and
flood and/or surface water insurance, in an amount up to [...***...] of the full
replacement cost (including debris removal and demolition) of the Building.

14.  Assignment or Sublet.

         a.  Tenant  shall not assign  this Lease or sublet the  Premises or any
portion  thereof without the prior written consent of Landlord in each instance,
which consent shall not, subject to Landlordis rights under clause (i) below, be
unreasonably  withheld.  If Tenant desires to assign this Lease or to sublet the
Premises,  or any part thereof,  Tenant shall give to Landlord written notice of
its  intent at least  sixty  (60) days in  advance  of the date on which  Tenant
desires to assign or sublet the Premises, which notice shall designate the terms
of the proposed  assignment or sublet,  the identity of the proposed assignee or
sublessee,  and shall be  accompanied  by financial  statements of such proposed
assignee or sublessee and such other  information  regarding  such party and its
business  and  reputation  as shall be required  by  Landlord  to  evaluate  the
proposed  assignment  or  sublet.  Landlord  shall have  thirty  (30) days after
receipt

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of Tenant's written notice and the above specified  information  within which to
notify  Tenant in writing  that  Landlord  elects to (i) consent to the proposed
assignment or sublet as described in Tenant's notice,  or (ii) reasonably refuse
to consent to Tenantis  proposed  assignment or sublet,  stating the reasons for
such  refusal.  If Landlord  fails to notify  Tenant in writing of its  election
within the thirty  (30) day  period,  Landlord  shall be deemed to have made the
election  in clause (ii) above.  No consent by  Landlord  to any  assignment  or
sublet shall be deemed to be a consent to a use not permitted  under this Lease,
to any act in violation of this Lease or to any subsequent assignment or sublet.
No  assignment  or sublet  by  Tenant  shall  relieve  Tenant  of any  liability
theretofore or thereafter arising under this Lease. Any attempted  assignment or
sublet by Tenant in violation of the terms and  covenants of this Section  shall
be void.

         b.  Processing  Expenses.  Tenant shall pay to Landlord,  as Landlord's
cost of processing  each proposed  assignment or subletting  (whether or not the
same is ultimately  approved by Landlord or  consummated  by Tenant),  an amount
equal to the sum of (i) Landlord's  reasonable attorneys' and other professional
fees,   plus  (ii)  the  sum  of   $[...***...]   for  the  cost  of  Landlord's
administrative, accounting and clerical time (collectively, "Processing Costs").
Notwithstanding  anything to the contrary herein, Landlord shall not be required
to process any request for  Landlord's  consent to an  assignment  or subletting
until  Tenant has paid to  Landlord  the amount of  Landlord's  estimate  of the
Processing  Costs. When the actual amount of the Processing Costs is determined,
it shall be reconciled  with  Landlord's  estimate,  and any payments or refunds
required as a result thereof shall promptly thereafter be made by the parties.

         c.  Consideration  to  Landlord.  In the  event  of any  assignment  or
sublease,  whether  or not  requiring  Landlord's  consent,  Landlord  shall  be
entitled  to  receive,   as  additional  rent  hereunder,   [...***...]  of  any
consideration (including, without limitation, payment for leasehold improvements
(including the Tenant  Improvements  or any other  Alterations) in excess of the
Assignment  or  Subletting  Costs (as defined and  amortized as set forth below)
paid by the assignee or subtenant  for the  assignment  or sublease  and, in the
case of a sublease,  Tenant shall pay to Landlord on a monthly  basis the excess
of the amount of rent and other  consideration  paid for the sublet space by the
subtenant over the amount of Monthly Base Rent under Section 4 above,  Operating
Expenses under Section 5 above, and Assignment or Subletting Costs (amortized as
set forth below),  attributable to the sublet space for the corresponding month.
"Assignment or Subletting  Costs" shall mean, (i) on an amortized basis over the
term of the sublease or assignment,  any brokerage commissions paid by Tenant in
connection  with  the  subletting  or  assignment  (not  to  exceed  commissions
typically  paid in the  market at the time of such  subletting  or  assignment),
Tenant's  reasonable  costs of advertising  the space for sublease or assignment
and any improvement allowance paid by Tenant to the subtenant or assignee or any
improvement  costs paid by Tenant solely to prepare the space for the assignment
or  sublet,  and (ii)  [...***...],  provided  that,  as a  condition  to Tenant
recapturing  the  Assignment  or  Subletting  Costs,  Tenant  shall  provide  to
Landlord,  within sixty (60) days of Landlord's  execution of Landlord's consent
to the  assignment or  subletting,  a detailed  accounting of the  Assignment or
Subletting  Costs and supporting  documents,  such as receipts and  construction
invoices. Upon Landlord's request, Tenant shall direct any subtenant or assignee
to pay directly to Landlord the amounts due to it pursuant to this Section 14.c.
on account of such  sublease or  assignment.  If there is more than one sublease
under this Lease, the amounts (if any) to be paid by Tenant to Landlord pursuant
to this Section  14.c.  shall be  separately  calculated  for each  sublease and
amounts due Landlord  with regard to any one sublease may not be offset  against
rental and other  consideration  pertaining to or due

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under any other sublease.  For purposes of clause (ii) above,  the  [...***...]*
shall be included in the  Assignment  or Subletting  Costs.  For purposes of the
amortization  in clauses (i) and (ii) above,  such  amortization  shall be at an
interest rate per annum equal to [...***...] percentage points over the Treasury
Rate charged at the time such costs are paid by Tenant.

         d. Documentation. No permitted assignment or subletting by Tenant shall
be  effective  until  there has been  delivered  to  Landlord  a fully  executed
counterpart of the assignment or sublease which  expressly  provides that (i) in
the case of a sublease,  the  subtenant  may not assign its  sublease or further
sublet the sublet space without  Landlord's prior written  consent,  (ii) in the
case of an assignment,  the assignee assumes all of Tenant's  obligations  under
this Lease arising on or after the date of the assignment, and (iii) in the case
of a sublease,  the  subtenant  agrees to be and remain  jointly  and  severally
liable with Tenant to Landlord for the payment of Rent  pertaining to the sublet
space in the amount set forth in the sublease, and for the performance of all of
the terms and  provisions  of this  Lease  pertaining  to the sublet  space.  In
addition  to the  foregoing,  no  assignment  or  sublease  by  Tenant  shall be
effective   until  there  has  been  delivered  to  Landlord  a  fully  executed
counterpart of Landlord's consent to assignment or sublease form, as applicable.
The failure or refusal of a subtenant or assignee to execute any such instrument
shall not release or discharge  the  subtenant or assignee from its liability as
set forth above.  Notwithstanding the foregoing,  no subtenant or assignee shall
be permitted to occupy the Premises  unless and until such subtenant or assignee
provides Landlord with  certificates  evidencing that such subtenant or assignee
is carrying all insurance coverage required of it under this Lease.

         e. No Merger.  Without  limiting any of the  provisions of this Section
14, the  voluntary  or other  surrender  of this  Lease by  Tenant,  or a mutual
cancellation by Landlord and Tenant,  shall not work a merger, and shall, at the
option of Landlord,  terminate all or any existing subleases or subtenancies or,
at the option of Landlord,  operate as an  assignment  to Landlord of any or all
such  subleases or  subtenancies.  If Landlord does elect that such surrender or
cancellation  operate  as an  assignment  of  such  subleases  or  subtenancies,
Landlord  shall in no way be liable for any  previous  act or omission by Tenant
under the subleases or for the return of any deposit(s) under the subleases that
have not been actually delivered to Landlord, nor shall Landlord be bound by any
sublease  modification(s) executed without Landlord's consent or for any advance
rental payment by the subtenant in excess of one month's rent.

         f. Indirect Assignments. For purposes of this Section 14, the following
events shall be deemed an assignment or sublease, as appropriate: (i) a transfer
of Control (as defined  below) of Tenant or any  subtenant or  assignee,  or any
entity  controlling any of them, in a single  transaction or a series of related
or unrelated  transactions  (including,  without  limitation,  by consolidation,
merger, acquisition or reorganization),  except that the transfer of outstanding
capital stock or other listed equity  interests by persons or parties other than
"insiders"  within  the  meaning  of the  Securities  Exchange  Act of 1934,  as
amended,  through the  "over-the-counter"  market or any recognized  national or
international  securities exchange, shall not be included in determining whether
Control has been  transferred;  (ii) a reduction of Tenant's assets to the point
that this Lease and/or other leases are substantially Tenant's only asset(s); or
(iii) a change or conversion  in the form of entity of Tenant,  any subtenant or
assignee,  or any  entity  controlling  any of them,  which  has the  effect  of
limiting the liability of any of the  partners,  members or other owners of such
entity.  "Control" shall mean direct or indirect ownership of 50% or more of all
of the  voting  stock of a  corporation  or 50% or more of the  voting  legal or
equitable  interest  in any other  business  entity,  or the power to direct the
management  and  operations  of any  entity (by equity  ownership,

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contract or otherwise).  Notwithstanding  anything to the contrary  contained in
this  Lease,  any  transfer  of Control  which does not result in a decrease  in
Tenant's  net  worth and does not have a  material  adverse  effect on  Tenant's
ability  to perform  its  obligations  under  this Lease  shall not be deemed an
assignment  or sublease for purposes of this Section 14, or any other  provision
of this Lease.

         g. Affiliates; Successors.  Notwithstanding anything to the contrary in
Section  14.a.,  but subject to the other  provisions of this Section 14, Tenant
may assign this Lease or sublet the  Premises or any  portion  thereof,  without
Landlord's  consent,  to any  partnership,  corporation  or other  entity  which
controls,  is  controlled  by, or is under common  control with Tenant  (control
being defined for such purposes as ownership of 50% or more of all of the voting
stock of a corporation or 50% or more of the voting legal or equitable  interest
in any  other  business  entity,  and the  power to direct  the  management  and
operations  of, the relevant  entity) (an  "Affiliate")  or to any  partnership,
corporation or other entity resulting from a merger or consolidation with Tenant
or which  acquires  all or  substantially  all of  Tenant's  assets  (through  a
transfer of assets or equity  interests  in Tenant) as a going  concern and such
assets  include  substantial  assets  other  than  this  Lease (a  "Successor"),
provided that (i) Landlord receives at least ten (10) days' prior written notice
of the assignment or subletting,  in which Tenant shall  expressly  confirm that
Tenant remains  primarily  liable (together with the assignee in the event of an
assignment) for all of the  obligations of the Tenant under this Lease,  (ii) in
the case of an assignment to a Successor,  the Successor's net worth is not less
than  Tenant's  net worth  immediately  prior to such  assignment  (or series of
transactions  of  which  such  assignment  is a  part),  (iii)  in the case of a
subletting or assignment to an Affiliate, the Affiliate remains an Affiliate for
the  duration  of the  subletting  or the balance of the term in the event of an
assignment,  (iv) Landlord  receives a fully  executed copy of the assignment or
sublease  agreement  between  Tenant and the Affiliate or Successor at least ten
(10) days prior to the effective date of such  assignment or sublease,  in which
the  Affiliate  or  Successor,  as the case may be,  assumes (in the event of an
assignment)  all of Tenant's  obligations  under this Lease,  and agrees (in the
event of a sublease) that such subtenant  will, at Landlord's  election,  attorn
directly to Landlord in the event that this Lease is terminated  for any reason,
(v) the use of the  Premises  will  not  materially  change  from the use of the
Premises  prior to such  assignment  (or  series of  transactions  of which such
assignment is a part) or subletting,  and (vi) in the case of an assignment, the
essential purpose of such assignment is to transfer an active,  ongoing business
with  substantial  assets in addition to this Lease, and the assignment is not a
subterfuge  by  Tenant  to  avoid  it  obligations   under  this  Lease  or  the
restrictions on assignment and subletting contained herein.

15.  Default.

         a. Tenant's  Default.  A material  breach of this Lease by Tenant shall
exist  if  any  of  the  following  events   (severally,   "Event  of  Default";
collectively,  "Events of Default") shall occur: (i) if Tenant shall have failed
to pay Base Rent, Tenant's Percentage Share of Operating Expenses,  or any other
sum required to be paid  hereunder,  including any interest due under Section 3,
within five (5) days after the same is due hereunder;  (ii) if Tenant shall have
failed to perform any term,  covenant or  condition  of this Lease  except those
requiring the payment of money,  and Tenant shall have failed to cure the breach
within thirty (30) days after  written  notice from Landlord if the breach could
reasonably be cured within the thirty (30) day period; provided, however, if the
failure could not  reasonably  be cured within the thirty (30) day period,  then
Tenant  shall not be in default  unless it has failed to promptly  commence  and
thereafter  continue to make diligent and reasonable efforts to cure the failure
as soon as  practicable  as reasonably  determined by Landlord;  (iii) if Tenant
shall have  assigned  its assets for the benefit of its  creditors;  (iv) if the
sequestration  of,  attachment  of, or execution  on, any  material  part of the
property of

                                       20

<PAGE>


Tenant upon the Premises or on any property essential to the conduct of Tenant's
business upon the Premises shall have occurred,  and Tenant shall have failed to
obtain a return or release of the property  within thirty (30) days  thereafter,
or prior to sale pursuant to any sequestration, attachment or levy, whichever is
earlier;  (v) if Tenant shall have failed to  continuously  and  uninterruptedly
conduct its  business in the  Premises,  or shall have  abandoned or vacated the
Premises;  (vi) if a court  shall  have  made or  entered  any  decree  or order
adjudging  Tenant to be  insolvent,  or approving  as properly  filed a petition
seeking  reorganization of Tenant, or directing the winding up or liquidation of
Tenant, and the decree or order shall have continued for a period of thirty (30)
days;  (vii) if Tenant shall make or suffer any  transfer  which  constitutes  a
fraudulent or otherwise  avoidable  transfer  under any provision of the federal
Bankruptcy  Laws or any  applicable  state law;  or (viii) if Tenant  shall have
failed to comply with the  provisions  of Sections 22 or 24 of this Lease within
the time periods stated therein.  An Event of Default shall constitute a default
under this Lease.

         b. Remedies Upon Tenant's Default.  Upon an Event of Default,  Landlord
shall have the following remedies,  in addition to all other rights and remedies
provided by law, equity,  statute or otherwise  provided in this Lease, to which
Landlord may resort cumulatively or in the alternative:

                   (i)Landlord has the remedy described in California Civil Code
Section  1951.4 (a landlord  may continue the lease in effect after the tenant's
breach and abandonment and recover rent as it becomes due, if the tenant has the
right to sublet and assign  subject  only to  reasonable  limitations),  and may
continue this Lease in full force and effect,  and this Lease shall  continue in
full force and effect as long as Landlord does not terminate  Tenant's  right to
possession,  and Landlord shall have the right to collect Rent when due.  During
the period  Tenant is in default,  Landlord may enter the Premises and relet it,
or any part of it, to third parties for Tenant's account, provided that any Rent
in excess of the Rent due hereunder  shall be payable to Landlord.  Tenant shall
be liable immediately to Landlord for all costs Landlord incurs in reletting the
Premises,  including,  without  limitation,  brokers'  commissions,  expenses of
cleaning and redecorating the Premises required by the reletting and like costs.
Reletting may be for a period  shorter or longer than the remaining Term of this
Lease. Tenant shall pay to Landlord the Rent and other sums due under this Lease
on the dates the Rent is due,  less the Rent and other  sums  Landlord  receives
from any  reletting.  No act by Landlord  allowed by this  Subsection  (i) shall
terminate this Lease unless  Landlord  notifies  Tenant in writing that Landlord
elects to terminate this Lease.

                   (ii) Landlord may terminate  Tenant's  right to possession of
the  Premises at any time by giving  written  notice to that  effect.  No act by
Landlord other than giving written  notice to Tenant of such  termination  shall
terminate this Lease. Acts of maintenance,  efforts to relet the Premises or the
appointment  of a  receiver  on  Landlord's  initiative  to  protect  Landlord's
interest  under this Lease shall not  constitute a termination of Tenant's right
to  possession.  On  termination,  Landlord  shall  have the right to remove all
personal  property of Tenant and store it at Tenant's  cost and to recover  from
Tenant as  damages:  (a) the worth at the time of award of unpaid Rent and other
sums due and payable which had been earned at the time of termination;  plus (b)
the worth at the time of award of the amount by which the unpaid  Rent and other
sums due and payable which would have been payable after  termination  until the
time of award  exceeds the amount of the Rent loss that Tenant proves could have
been reasonably  avoided;  plus (c) the worth at the time of award of the amount
by which the unpaid  Rent and other sums due and  payable for the balance of the
Term after the time of award  exceeds  the  amount of the Rent loss that  Tenant
proves  could be  reasonably  avoided;  plus (d) any other  amount  necessary to
compensate Landlord for all the detriment proximately caused by Tenant's failure
to perform  Tenant's  obligations  under this Lease,  or which,  in the ordinary
course  of  things,  would be likely to  result  therefrom,  including,

                                       21

<PAGE>


without limitation,  any costs or expenses incurred by Landlord: (1) in retaking
possession  of the  Premises,  including  reasonable  attorneys'  fees and costs
therefor;  (2)  maintaining  or  preserving  the Premises for reletting to a new
tenant,  including repairs or alterations to the Premises for the reletting; (3)
leasing  commissions;  (4) any other costs necessary or appropriate to relet the
Premises;  and (5) at Landlord's election,  such other amounts in addition to or
in lieu of the  foregoing  as may be permitted  from time to time by  California
Civil Code Section 1951.2 or any other laws of the State of California.

                      The "worth at the time of award" of the  amounts  referred
to in  Subsections  (ii)(a) and (ii)(b) is computed by allowing  interest at the
lesser of  [...***...]  per annum or the maximum  rate  permitted by law, on the
unpaid Rent and other sums due and payable from the date due through the date of
award.  The "worth at the time of award" of the amount referred to in Subsection
(ii)(c)  is  computed  by  discounting  the amount at the  discount  rate of the
Federal  Reserve Bank of San  Francisco  at the time of award,  plus one percent
(1%).  Tenant waives  redemption or relief from forfeiture under California Code
of Civil Procedure  Sections 1174 and 1179, or under any other present or future
law, if Tenant is evicted or Landlord takes possession of the Premises by reason
of any default of Tenant hereunder.

         c. Landlord's Default. Landlord shall not be deemed to be in default in
the performance of any obligation required to be performed by Landlord hereunder
unless and until  Landlord has failed to perform the  obligation  within  thirty
(30) days after receipt of written  notice by Tenant to Landlord  specifying the
obligation Landlord has failed to perform; provided, however, that if the nature
of  Landlord's  obligation  is such that more than thirty (30) days are required
for its  performance,  then  Landlord  shall not be deemed to be in  default  if
Landlord shall commence the  performance  of such  obligation  within the thirty
(30)  day  period  and  thereafter  shall  diligently   prosecute  the  same  to
completion.

16.  Landlord's Right to Perform Tenant's Covenants.

         If Tenant  shall at any time fail to make any  payment or  perform  any
other act on its part to be made or performed  under this Lease,  Landlord  may,
but shall not be obligated  to, make the payment or perform any other act to the
extent  Landlord may deem desirable and, in connection  therewith,  pay expenses
and employ  counsel.  Any payment or  performance by Landlord shall not waive or
release Tenant from any obligations of Tenant under this Lease. All sums so paid
by Landlord,  and all  penalties,  interest and costs in  connection  therewith,
shall be due and  payable  by  Tenant  on the  next day  after  any  payment  by
Landlord, together with interest thereon at the Interest Rate, from that date to
the date of payment  thereof by Tenant to Landlord,  plus  collection  costs and
attorneys'  fees.  Landlord  shall  have the same  rights and  remedies  for the
nonpayment thereof as in the case of default in the payment of Base Rent.

17.  Security Deposit.

         Tenant has deposited with Landlord the Security Deposit,  in the amount
specified in the Basic Lease Information,  as security for the full and faithful
performance  of every  provision  of this Lease to be  performed  by Tenant.  If
Tenant  defaults with respect to any provision of this Lease,  Landlord may use,
apply or retain all or any part of the  Security  Deposit for the payment of any
Rent or other sum in default,  for the payment of any amount which  Landlord may
expend or become obligated to expend by reason of Tenant's  default,  or for any
loss or  damage  which  Landlord  may  suffer by  reason  of  Tenant's  default;

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*    Confidential Treatment Requested

                                       22

<PAGE>


provided,  however,  that  the  Security  Deposit  shall  not  be a  measure  or
limitation  of  Landlord's  damages or constitute a bar or defense to any of the
Landlordis  other  remedies  under this Lease or at law.  If any  portion of the
Security Deposit is used or applied, Tenant shall deposit with Landlord,  within
ten (10) days after written  demand  therefor,  cash in an amount  sufficient to
restore the  Security  Deposit to its  original  amount.  Landlord  shall not be
required to keep the  Security  Deposit  separate  from its general  funds,  and
Tenant  shall not be  entitled to interest  on the  Security  Deposit.  Upon the
expiration or earlier termination of this Lease, and Tenantis fulfillment of all
of its  obligations  hereunder  (including  any  obligations  which survive such
expiration or earlier  termination),  Landlord shall return the Security Deposit
(or the balance thereof after application as aforesaid) to Tenant.

18.  Surrender of Premises.

         By taking  possession  of the  Premises,  except as otherwise  provided
herein, Tenant shall be deemed to have accepted the Premises and the Property in
good, clean and completed condition and repair,  subject to all applicable laws,
codes and  ordinances.  On the  Expiration  Date or earlier  termination of this
Lease,  Tenant shall  surrender  the Premises to Landlord in its condition as of
the applicable Rent Commencement Date, normal wear and tear excepted,  provided,
however,  that Tenant shall  remove from the Premises all of Tenant's  Removable
Trade Fixtures and Portable Equipment and any Alterations required to be removed
pursuant to Section 9 of this Lease.  Tenant  shall repair any damage or perform
any restoration  work required by the removal.  If Tenant fails to timely remove
any Removable  Trade Fixtures,  Portable  Equipment or Alterations as aforesaid,
Landlord  may  remove  the  property  and store  and/or  dispose  of the same at
Tenant's expense,  including  interest at the Interest Rate. If the Premises are
not so surrendered  at the  termination  of this Lease,  Tenant shall  indemnify
Landlord  against all Claims  resulting from delay by Tenant in so  surrendering
the Premises,  including,  without limitation, any claims made by any succeeding
tenant,  losses to Landlord  due to lost  opportunities  to lease to  succeeding
tenants,  and  attorneys'  fees and costs.  Tenant shall give written  notice to
Landlord at least thirty (30) days prior to vacating the Premises and shall meet
with Landlord for a joint inspection of the Premises at the time of vacating. In
the event of Tenant's  failure to give such notice or  participate in such joint
inspection,  Landlord's  inspection at or after  Tenant's  vacating the Premises
shall  conclusively  be deemed  correct  for  purposes of  determining  Tenant's
responsibility  for removal of  Alterations  and repairs and  restoration of the
Premises.

19.  Holding Over.

         If Tenant  remains  in  possession  of all or any part of the  Premises
after  the  expiration  of the Term or the  earlier  termination  of this  Lease
without  Landlord's  prior  written  consent,  the tenancy shall be a tenancy at
sufferance  only and shall not constitute a renewal or extension for any further
term,  regardless of whether Landlord shall accept Rent for any such period.  In
such event,  Base Rent shall be increased in an amount equal to  [...***...]  of
the Base Rent during the last month of the Term (including any extensions),  and
any other sums due under this Lease shall be payable in the  amount,  and at the
times,  specified  in this Lease.  The  tenancy  shall be subject to every other
term, condition, covenant and agreement contained in this Lease, except that any
renewal or extension option in favor of Tenant shall not be applicable.  No such
increase  shall impair  Landlordis  other rights and remedies  against Tenant by
reason of such  holding  over by Tenant,  and Tenant  shall  vacate the Premises
immediately upon Landlord's request.

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*    Confidential Treatment Requested

                                       23

<PAGE>


20.  Access to Premises.

         Tenant  shall  permit  Landlord and its agents to enter the Premises at
all reasonable  times,  except in the case of an emergency (in which event entry
shall be made when  necessary),  to inspect  the  Premises,  to post  Notices of
Nonresponsibility  and  similar  notices,  to show the  Premises  to  interested
parties such as  prospective  mortgagees,  purchasers and tenants to provide any
services  required  of  Landlord  hereunder,   to  make  necessary  alterations,
additions,  improvements  or repairs  either to the Premises,  the Building,  or
other  premises  within the  Building,  and to  discharge  Tenant's  obligations
hereunder when Tenant has failed to do so within a reasonable time after written
notice  from  Landlord.  No such entry shall give rise to an  abatement  of Rent
hereunder,  constitute a constructive  eviction,  or otherwise diminish Tenant's
obligations  under this Lease.  In exercising  its rights under this Section 20,
Landlord  shall at all times  endeavor to minimize  interference  with  Tenant's
operations,  to the  extent  practicable.  During  the  last  year of the  Term,
Landlord shall have the right to erect on the exterior of the Premises and/or on
the exterior or in the Common  Areas of the  Building and the Property  suitable
signs indicating that the Premises are available for lease.

21.  Signs.

         The size,  design,  color,  location and other physical  aspects of any
sign in or on the  Premises  shall be subject to the CC&R's,  Rules,  Landlord's
approval prior to installation,  and to all Legal Requirements. The costs of any
permitted  sign,  and the costs of its  installation,  maintenance  and removal,
shall be at  Tenant's  sole  expense  and shall be paid  within ten (10) days of
Tenant's receipt of a bill from Landlord for the costs. In no event shall Tenant
be permitted to place any sign, logo or other  identification on the exterior of
the Building, in the Buildingis Common Areas (other than on a Building directory
maintained to identify the Buildingis tenants),  or upon the Property,  or which
is inside the Premises but visible from outside of the Premises (other than upon
the door(s) to the Premises),  without  Landlord's prior written consent in each
instance.

22.  Subordination.

         a. Subordinate Nature.  Except as provided in Subsection b., this Lease
is subject and  subordinate to all ground and underlying  leases,  mortgages and
deeds of trust  which now or may  hereafter  affect the  Property or any portion
thereof,  to the CC&R's,  and to all  renewals,  modifications,  consolidations,
replacements  and  extensions  of the  foregoing,  without the  necessity of any
further  documentation  evidencing  such  subordination.   Notwithstanding  such
self-operative  subordination,  within  ten (10) days after  Landlord's  written
request therefor,  subject to Section 22.d. below,  Tenant shall execute any and
all  documents  required by Landlord,  the lessor under any ground or underlying
lease  ("Ground  Lessor"),  or the holder or holders of any  mortgage or deed of
trust  ("Holder"),  evidencing  this Lease to be  subordinate to the lien of any
such  lease,  mortgage  or deed of  trust,  as the  case may be.  Tenant  hereby
irrevocably  appoints  Landlord  as  Tenant's  attorney-in-fact  to execute  and
deliver  any such  instrument  in the name of Tenant  if  Tenant  fails to do so
within such time. If the interest of Landlord in the Property or the Building is
transferred to any Ground Lessor or Holder pursuant to or in lieu of proceedings
for  enforcement  of any such lease,  mortgage,  or deed of trust,  Tenant shall
immediately and  automatically  attorn to the Ground Lessor or Holder,  and this
Lease  shall  continue  in full force and effect as a direct  lease  between the
Ground Lessor or Holder and Tenant on the terms and conditions set forth herein.

                                       24

<PAGE>


         b. Possible  Priority of Lease.  If a Ground Lessor or a Holder advises
Landlord  that it desires or requires  this Lease to be prior and  superior to a
lease,  mortgage or deed of trust,  Landlord may notify Tenant. Within seven (7)
days of Landlord's notice,  Tenant shall execute,  have acknowledged and deliver
to  Landlord  any and all  documents  or  instruments,  in the  reasonable  form
presented to Tenant, which Landlord,  Ground Lessor or Holder deems necessary or
desirable to make this Lease prior and  superior to the lease,  mortgage or deed
of trust.

         c. Lease  Modification.  If, in connection with obtaining financing for
the Property or any portion  thereof,  any Holder or Ground Lessor shall request
reasonable  modification  to this Lease as a condition  to such ground  lease or
financing, Tenant shall execute and deliver to Landlord, within ten (10) days of
Landlord's request, any such modification agreement so requested,  provided such
modifications  do not  adversely  affect  Tenant's  rights or increase  Tenant's
obligations hereunder.

         d.  Nondisturbance  Agreement.  Prior  to the  date on  which  Landlord
commences  pouring the  foundations  for the first Building to be located on the
Property, Landlord shall deliver to Tenant a subordination,  non-disturbance and
attornment agreement from each Ground Lessor and Holder existing as of such date
in form reasonably  required by such party and reasonably  acceptable to Tenant.
If Landlord fails to timely deliver such  agreements,  Tenant may terminate this
Lease by notice to Landlord within ten (10) days  thereafter.  As a condition to
subordination  of this Lease to any Superior  Interest  arising after such date,
Landlord shall deliver to Tenant, and Tenant agrees to execute, a subordination,
non-disturbance  and attornment  agreement from the applicable  Ground Lessor or
Holder in form  reasonably  required by such party and reasonably  acceptable to
Tenant.

23. Transfer of the Property.

         Upon  transfer  of the  Property  and  assignment  of this  Lease,  and
assumption  by  the  purchaser  or  assignee  of  the  obligations  of  Landlord
thereafter  arising  under this  Lease,  Landlord  shall be  entirely  freed and
relieved of all liability for such  obligations,  and if Landlord shall transfer
the  Security  Deposit to the  transferee  of  Landlordis  interest  in the Real
Property,  Landlord  shall be  released  from  all  liability  for the  Security
Deposit. Tenant shall attorn to any entity purchasing or otherwise acquiring the
Premises at any sale or other proceeding.

24.  Estoppel Certificates; Financial Statements.

         Within ten (10) days following written request by Landlord from time to
time  throughout  the Term,  Tenant  shall  execute  and  deliver to Landlord an
estoppel  certificate in the form prepared by Landlord.  The certificate  shall:
(i) certify  that this Lease is  unmodified  and in full force and effect or, if
modified,  state the nature of the  modification and certify that this Lease, as
so  modified,  is in full force and  effect,  and the date to which the Rent and
other charges are paid;  (ii)  acknowledge  that there are not, to Tenant's best
knowledge,  any uncured defaults on the part of Landlord hereunder,  or if there
are  uncured  defaults  on the part of the  Landlord,  state  the  nature of the
uncured defaults; and (iii) set forth such other matters regarding this Lease as
may be required either by Landlord, any existing or prospective Ground Lessor or
Holder, or a prospective purchaser of the Property from Landlord. At the request
of Landlord from time to time during the Term,  Tenant shall provide to Landlord
its current  financial  statements or other  information  setting forth Tenant's
financial  condition and net worth. If Tenant is a publicly traded  corporation,
Tenant may satisfy its obligations under the preceding sentence by delivering to
Landlord  Tenant's then most recent  publicly  available  financial  statements.
Landlord shall use such  documentation  solely for purposes of this Lease and in
connection with the ownership, financing,

                                       25

<PAGE>


management and disposition of the Real Property.

25.  Mortgagee Protection.

         In the event of any default on the part of  Landlord,  Tenant will give
notice by  registered  or certified  mail to each Ground Lessor and Holder whose
identity  has been  disclosed  to Tenant,  and shall offer the Ground  Lessor or
Holder a  reasonable  opportunity  after such  notice (but in no event less than
thirty (30) days) to cure the default,  including  time to obtain  possession of
the Property or the Premises by lease  termination,  power of sale or a judicial
foreclosure (as applicable), if such should prove necessary to effect a cure. In
no event  shall any Ground  Lessor or Holder in any way or to any extent be: (a)
liable for any act or omission of any prior  Landlord  in  contravention  of any
provision of this Lease; or (b) subject to any offsets, claims or defenses which
Tenant  might have  against any prior  Landlord;  or (c) bound by any Rent which
Tenant  might have paid for more than  thirty  (30) days in advance to any prior
Landlord;  or (d) bound by any  agreement  or  modification  of this  Lease made
without such Ground Lessor's or Holder's written consent.  Tenant agrees that if
any Ground Lessor or Holder acquires  possession of the Premises or title to the
Property as a result of  termination  of its ground lease or foreclosure of such
Holder's  deed of  trust  or  other  security  instrument,  as  applicable,  the
acceptance  of a lease  surrender  or deed  in  lieu  of  such  foreclosure,  or
otherwise,  the  provisions of Section 36 below shall be applicable to liability
of such Ground Lessor or Holder as successor Landlord under this Lease.

26.  Attorneys' Fees.

         If either party shall bring any action or legal  proceeding for damages
for an alleged  breach of any provision of this Lease,  to recover rent or other
sums due, to  terminate  the tenancy of the  Premises or to enforce,  protect or
establish  any term,  condition  or  covenant  of this  Lease or right of either
party,  the  prevailing  party shall be  entitled  to recover,  as a part of the
action  or  proceedings,  or in a  separate  action  brought  for that  purpose,
reasonable attorneys' fees and court costs as may be fixed by the court or jury.
The  prevailing  party shall be the party which secures a final  judgment in its
favor,  provided  that if the party  bringing any action shall  dismiss the same
without  the  consent of the other  party,  the other  party shall be deemed the
prevailing party.

27.  Brokers.

         Tenant  warrants and  represents  that it has had no dealings  with any
real estate broker or agent in connection  with the  negotiation  of this Lease,
except for any brokers(s) specified in the Basic Lease Information,  and that it
knows of no other real  estate  broker or agent who is or might be entitled to a
fee,  commission or other  compensation  in connection  with this Lease.  Tenant
shall  indemnify  and  hold  harmless  Landlord  from  and  against  any and all
liabilities or expenses (including reasonable attorneys' fees and costs) arising
out of claims made by any other broker or  individual  for a fee,  commission or
other compensation resulting from this Lease.

28.  Parking.

         Tenant  shall  have  the  right  to  park  in  the  Buildings'  parking
facilities,  in common with other tenants of the Buildings,  upon such terms and
conditions as may from time to time be established  by Landlord.  There shall be
no charge  for any  portion of the  parking  facilities  which is not  reserved.
Tenant

                                       26

<PAGE>


shall  have the right to use  [...***...]  parking  spaces on the  Property  per
[...***...]  rentable  square feet of the  Premises set forth in the Basic Lease
Information  (as rounded down to the nearest whole space).  Tenant agrees not to
use in excess of such number of parking  spaces and further  agrees to cooperate
with Landlord and other tenants in the use of the parking  facilities.  Landlord
reserves the right, in its absolute discretion, to determine whether the parking
facilities are becoming  crowded and to allocate and assign parking spaces among
Tenant and the other tenants.  Landlord shall not be liable to Tenant, nor shall
this Lease be affected,  if any parking is impaired by  moratorium,  initiative,
referendum,  law, ordinance,  regulation or order passed,  issued or made by any
governmental or quasi-governmental body or by fire or other casualty.

29.  Utilities and Services.

         Tenant shall arrange for all telephone,  water,  gas,  electricity  and
other power and utilities  which it shall require in connection  with its use or
occupancy of the Premises and shall pay for the same,  together  with any taxes,
penalties,  surcharges or the like  pertaining  thereto.  Landlord shall have no
obligation to furnish any utilities or services to the Premises or any equipment
providing for the same. Without  limitation,  Tenant shall be solely responsible
for providing such heating,  ventilation  and air  conditioning  ("HVAC") to the
Premises as Tenant shall  require for the  comfortable  occupancy  thereof.  Any
equipment or systems which Tenant shall require in order to supply HVAC shall be
subject  to the  provisions  of Section 9 above.  Tenant  shall  obtain,  at its
expense all electric light bulbs, ballasts and tubes as it shall require for the
Premises.  If any of the  foregoing  utilities  or services  are not  separately
metered to Tenant,  Tenant shall pay a reasonable  proportion,  as determined by
Landlord,  of all charges  jointly  serving  the  Premises  and other  premises.
Landlord  shall not be liable for any damages  directly or indirectly  resulting
from nor shall the Base Rent,  Operating  Expenses  or any other  monies owed by
Tenant to  Landlord  under  this Lease be abated or reduced by reason of (a) the
installation,  use or  interruption  of use of any equipment  used in connection
with the furnishing of any of the foregoing utilities and services,  (b) failure
to furnish or delay in furnishing  any such utilities or services for any reason
whatsoever, or (c) the limitation,  curtailment, rationing or restriction on use
of water,  electricity,  gas or any other form of energy or any other service or
utility whatsoever serving the Premises or the Real Property.  Landlord shall be
entitled to cooperate voluntarily and in a reasonable manner with the efforts of
national,  state or local government  agencies or utility  suppliers in reducing
energy or other resource  consumption,  provided that the majority of the owners
of comparable  business parks in the Comparable  Market are also so cooperating.
The  obligation to make  services  available  hereunder  shall be subject to the
limitations of any such voluntary, reasonable program.

30.  Intentionally Deleted.

31.  Acceptance.

         Delivery of this Lease, duly executed by Tenant,  constitutes  Tenantis
offer to lease the  Premises  as set forth  herein,  and under no  circumstances
shall such  delivery be deemed to create an option or  reservation  to lease the
Premises  for the  benefit of Tenant.  This Lease  shall  become  effective  and
binding only upon execution  hereof by Landlord and delivery of a signed copy to
Tenant.  If Landlord does not accept the Tenant's  offer,  any sums delivered by
Tenant with its offer shall be returned to Tenant.

32.  Use of Building Name.

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         Tenant  shall not employ the name of the  Building in the name or title
of its business or occupation,  or for any other purpose, except to identify the
address of the Building, without Landlord's prior written consent, which consent
Landlord may  withhold in its sole  discretion.  Landlord  reserves the right to
change  the name of the  Building  without  Tenant's  consent  and  without  any
liability to Tenant.

33.  Recording.

         Neither  Landlord nor Tenant shall record this Lease,  nor a short form
memorandum of this Lease, without the prior written consent of the other.

34.  Quitclaim.

         Upon any termination or expiration of this Lease pursuant to its terms,
Tenant, at Landlord's request,  shall execute,  have acknowledged and deliver to
Landlord a quitclaim deed of all Tenant's interest in the Premises, Building and
Property created by this Lease.

35.  Notices.

         Any  notice,  demand or request  required  or desired to be given under
this Lease  shall be in writing  sent to the address of the party  specified  in
this  Lease,  and  shall be  given  by hand  delivery,  electronic  mail  (e.g.,
telecopy),  overnight  courier  service (e.g.  Federal  Express),  or the United
States mail, registered or certified,  the postage prepaid. All notices shall be
deemed to have been given when  received at the address of the party to which it
has been sent (or when such receipt is refused).  As of the date of execution of
this Lease,  the  addresses of Landlord and Tenant are as specified in the Basic
Lease  Information.  Either party may change its address by giving notice of the
change in accordance with this Section.

36.  Landlord's Exculpation.

         The term  "Landlord," as used in this Lease,  shall mean only the owner
or owners  (or lessee or lessees  under any ground or  underlying  lease) of the
Property at the time in question.  Notwithstanding  any other  provision of this
Lease, the liability of Landlord for its obligations under this Lease is limited
solely to Landlord's  interest in the Property as the same may from time to time
be  encumbered,  and no  personal  liability  shall at any time be  asserted  or
enforceable  against any other  assets of  Landlord  or against the  constituent
shareholders,  partners or other owners of Landlord, or the directors, officers,
employees  and agents of Landlord or such  constituent  shareholder,  partner or
other owner,  on account of any of Landlord's  obligations or actions under this
Lease.  Notwithstanding any other provision of this Lease, Landlord shall not be
liable for any consequential damages or interruption or loss of business, income
or  profits,  nor shall  Landlord  be liable  for loss of or damage to  artwork,
currency,  jewelry,  bullion, unique or valuable documents,  securities or other
valuables,  or for  other  property  not in the  nature  of  ordinary  fixtures,
furnishings and equipment.  Wherever in this Lease Tenant (a) releases  Landlord
from any claim or liability,  (b) waives or limits any right of Tenant to assert
any claim against  Landlord or to seek recourse against any property of Landlord
or (c) agrees to indemnify  Landlord against any matters,  the relevant release,
waiver, limitation or indemnity shall run in favor of and apply to Landlord, the
constituent  shareholders,  partners  or  other  owners  of  Landlord,  and  the
directors,  officers, employees and agents of Landlord and each such constituent
shareholder, partner or other owner. In no event shall any shareholder, partner,
member,  officer,  director  or other  constituent  of Landlord or its direct or
indirect  constituents ever be personally  liable for Landlord's  obligations or
liability under this Lease.

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37.  Additional Structures.

         Any diminution or interference with light, air or view by any structure
which may be erected on land adjacent to the Building shall in no way alter this
Lease or impose any liability on Landlord.

38.  Consents and Approvals.

         Wherever the consent,  approval,  judgment or determination of Landlord
is required or permitted under this Lease,  except as expressly  provided herein
Landlord  may  exercise  its sole  discretion  in granting or  withholding  such
consent or approval or in making such judgment or determination. Whenever Tenant
requests  Landlord  to take any action or give any consent or  approval,  Tenant
shall reimburse  Landlord for all of Landlord's  costs incurred in reviewing the
proposed  action  or  consent  (whether  or not  Landlord  consents  to any such
proposed  action),  including,  without  limitation,  reasonable  attorneys'  or
consultants' fees and expenses,  within ten (10) days after Landlord's  delivery
to Tenant of a statement of such costs. If it is determined that Landlord failed
to give its consent or approval where it was required to do so under this Lease,
Tenant's  sole  remedy  will be an order of specific  performance  or  mandatory
injunction  of the  Landlord's  agreement to give its consent or  approval.  The
review  and/or  approval by Landlord of any item shall not impose upon  Landlord
any  liability  for accuracy or  sufficiency  of any such item or the quality or
suitability  of such item for its  intended  use. Any such review or approval is
for the sole purpose of protecting Landlord's interest in the Real Property, and
neither  Tenant  nor any  Tenant  Party nor any  person or entity  claiming  by,
through  or under  Tenant,  nor any other  third  party  shall  have any  rights
hereunder by virtue of such review and/or approval by Landlord.

39.  Renewal Option.

         a.  Tenant  shall  have the  option  to renew  this  Lease  for one (1)
additional  term of five (5) years,  commencing  upon  expiration of the initial
Term. Such renewal option must be exercised,  if at all, by written notice given
by Tenant to Landlord  not later than  [...***...]  prior to  expiration  of the
initial Term.  Notwithstanding the foregoing,  this renewal option shall be null
and void and  Tenant  shall  have no  right to renew  this  Lease if on the date
Tenant  exercises such renewal option or on the date  immediately  preceding the
commencement date of the renewal period (i) the original Tenant named under this
Lease in the Basic Lease Information is not in occupancy of at least [...***...]
of the entire Premises then demised  hereunder or such Tenant does not intend to
continue to occupy at least  [...***...]  of the entire  Premises  then  demised
hereunder  (but  intends to assign this Lease or sublet the Premises in whole or
in part such that such occupancy requirement will not be met), or (ii) Tenant is
in default of any of its  obligations  under this  Lease.  For  purposes of this
Lease, the term "occupancy" means physical occupancy for the conduct of Tenant's
business,  and, without  limitation,  Tenant shall not be deemed in occupancy of
any space it has subleased or otherwise vacated.

                  If Tenant  exercises  such  renewal  option,  then  during the
renewal  term  all of the  terms  and  conditions  set  forth  in this  Lease as
applicable  to the  Premises  during the  initial  term shall  apply  during the
renewal  term,  except that (i) Tenant shall have no further right to renew this
Lease,  (ii)  Tenant  shall take the  Premises in their then  "as-is"  state and
condition  and  Landlord  shall  have  no  obligation  to  make  or pay  for any
improvements to the Premises,  and (iii) the monthly Base Rent payable by Tenant
for the Premises  shall be the "fair market rent" for the  Premises,  based upon
the terms of this Lease,  as renewed.  For purposes of this Section 39, the term
"fair market rent" shall mean the rental rate for comparable space

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under primary lease (and not sublease) to new tenants, taking into consideration
all  relevant  characteristics  of the space,  including  existing  improvements
[...***...],  situated in comparable  buildings in comparable  business parks in
the  Comparable  Market  (as  defined  in  Section  5.b.  above),   taking  into
consideration the then-prevailing  ordinary rental market practices with respect
to  tenant  concessions  (if  any)  (e.g.  not  offering  extraordinary  rental,
promotional  deals and other  concessions  to tenants which deviate from what is
the  then-prevailing  ordinary  practice  in an  effort to  alleviate  cash flow
problems,  difficulties in meeting loan obligations or other financial distress,
or in response to a greater than average  vacancy rate).  Fair market rent shall
include the periodic rental increases,  if any, that would be included for space
leased for the renewal  period.  The fair  market rent shall be mutually  agreed
upon by  Landlord  and Tenant in writing  within the thirty  (30)  calendar  day
period  commencing three (3) months prior to commencement of the renewal period.
If Landlord and Tenant do not agree upon the fair market rent within said thirty
(30) day period,  then the fair market rent shall be established by appraisal in
accordance with the procedures set forth in Exhibit E attached hereto.

         b.  Notwithstanding  anything in the  foregoing  or in Exhibit E to the
contrary, in no event shall the Base Rent during the renewal period be less than
the Base  Rent  payable  by  Tenant  for the  month  immediately  preceding  the
commencement of the renewal period (without regard to any temporary abatement of
rental then in effect pursuant to the provisions of this Lease).

40.  Right of First Offer.

         a. Commencing as of [...***...],  Tenant shall have a continuing  right
of first offer to lease any increment of space of more than [...***...] rentable
square feet in the  Property  which  thereafter  becomes  "available  for lease"
during  the  Term,  subject  to the  provisions  of  this  Section  40.  Without
limitation,  an increment of space shall not be deemed  "available for lease" if
(i) the tenant under an expiring  lease of such space desires to renew or extend
its lease of such space  pursuant to the  exercise of a right or option to do so
which  was  granted  (A) in such  party's  lease  of such  space  as  originally
executed,  or (B) in any amendment adding such space to such party's lease after
such lease was executed,  if such space was first offered to Tenant  pursuant to
this  Section 40 and Tenant did not  timely and  validly  exercise  its right to
lease such space,  or (ii) if any tenant of the  Property has an option or right
of first  offer or refusal or other  right to lease such space  pursuant  to the
exercise  of a right or option to do so which was  granted  (A) in such  party's
lease of space in the Property as originally  executed,  or (B) in any amendment
adding space to such party's lease after such lease was executed, if the subject
space is contiguous  to such added space,  and the added space and the rights to
such subject space were first offered to Tenant  pursuant to this Section 40 and
Tenant did not timely and validly  exercise its right to lease such space.  Each
increment of space as to which Tenant has the foregoing  right of first offer is
referred to herein as a "First Offer Increment".

         b. Landlord shall give Tenant written notice ("Landlord's  Availability
Notice)" of each First Offer Increment  within thirty (30) days after such First
Offer Increment becomes  available for lease, or, if sooner,  within thirty (30)
days after  Landlord  shall be in a position to  estimate  when such First Offer
Increment will become available for lease.  Landlord's Availability Notice shall
identify  the First  Offer  Increment  and  specify  the  availability  date (or
estimated availability date) of the First Offer Increment.

         c. If Tenant elects to lease the First Offer Increment, Tenant shall so
notify Landlord in writing within ten (10) Business Days after Tenant's  receipt
of  Landlord's  Availability  Notice.  If Tenant

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does not  exercise  its right to lease a First Offer  Increment  within such ten
(10) Business Day period, then for the one (1) year period following  Landlord's
Availability  Notice (as such period shall be extended,  by  Landlord's  written
notice to Tenant, to conclude any then pending negotiations between Landlord and
a prospective tenant of the First Offer Increment) Landlord shall be released of
its  obligation to offer or lease such First Offer  Increment to Tenant,  Tenant
shall have no rights with respect thereto,  and the provisions of this Paragraph
40 shall not again  apply to that First Offer  Increment  unless the First Offer
Increment again becomes  "available for lease" or remains "available for lease",
as the case may be,  after  the  expiration  of such  one (1)  year  period  (as
extended as described above).

         d. Upon Tenant's  election to lease a First Offer  Increment,  Landlord
and Tenant shall  promptly  enter into an  amendment of this Lease,  adding such
First Offer  Increment to the Premises on all the terms and conditions set forth
in this Lease as to the  Premises  then demised  hereunder,  except that (i) the
term of the lease to Tenant of such First Offer  Increment  shall  commence upon
the  availability  date specified in Landlord's  Availability  Notice (but in no
event  sooner than thirty  (30) days after the date of  Landlord's  Availability
Notice) and shall continue  coextensively  with the remaining Term of this Lease
and any extension thereof,  (ii) the initial monthly Base Rent payable by Tenant
for the First Offer  Increment  shall be the fair market rent for such space, as
defined in Section 39 above (and such rent shall be subject to adjustment at the
same  time  and in the same  manner  as the Base  Rent  for the  balance  of the
Premises  pursuant to Section 4.b. of this  Lease),  (iii)  Tenant's  Percentage
Share shall be increased to take into  account the First Offer  Increment  (such
increase to be determined by dividing the rentable  square footage of such First
Offer Increment by the rentable square footage of the Buildings (as set forth in
the Basic  Lease  Information),  and (iv)  Tenant  shall  take the  First  Offer
Increment in its then "as-is"  state and  condition  and Landlord  shall have no
obligation to make or pay for any improvements thereto. The fair market rent for
the First Offer  Increment  shall be mutually agreed upon by Landlord and Tenant
in writing within the thirty (30)-day period  commencing with Tenant's notice to
Landlord electing to lease such First Offer Increment,  but no sooner than three
(3) months prior to the availability date (or estimated  availability  date) set
forth in Landlord's  Availability  Notice.  If Landlord and Tenant are unable to
agree upon the fair market rent within  such thirty  (30)-day  period,  then the
fair  market rent shall be  established  by  appraisal  in  accordance  with the
procedures set forth in Exhibit E to this Lease. If the fair market monthly rent
for a First Offer Increment has not been established prior to the date the First
Offer Increment is to be added to the Premises, then Tenant shall pay as monthly
Base Rent for the First Offer  Increment the amount  produced by multiplying the
rentable  square  footage  of the First  Offer  Increment  by the Rent Floor (as
defined below) and, if the fair market monthly rent, as subsequently determined,
exceeds the rent paid by Tenant for the First Offer Increment  during the period
prior to the date the fair market monthly rent was determined,  Tenant shall pay
the deficiency to Landlord within ten (10) days after such determination, and if
the fair market rent, as subsequently determined,  is less than the rent so paid
by Tenant,  Landlord shall credit  Tenant's  overpayment  against  Tenant's next
accruing monthly Rent obligations with respect to the Premises.  As used herein,
"Rent Floor" means the Base Rent payable by Tenant (for all of the Premises then
leased hereunder), as calculated on an average basis per rentable square foot of
the Premises,  for the full calendar  month  immediately  preceding the calendar
month in which the  First  Offer  Increment  is added to the  Premises  (without
giving effect to any temporary rent abatements then in effect).

         e. If  Tenant  exercises  the  right of  first  offer  granted  herein,
Landlord does not guarantee that the First Offer  Increment will be available on
the  availability  date stated in Landlord's  Availability  Notice,  if the then
existing  occupants of the First Offer  Increment  shall  hold-over,  or for any
other reason beyond

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Landlord's  reasonable  control.  In such event, as Tenant's sole recourse,  the
term of this  Lease as to the  First  Offer  Increment  shall be  delayed  until
Landlord legally delivers the same to Tenant.

         f.  Notwithstanding  the  foregoing,  if as of  the  date  of  Tenant's
exercise of its right of first offer, or the date immediately preceding the date
the lease term of the First Offer  Increment  is to  commence,  (i) Tenant is in
default of any of its obligations  under this Lease, or (ii) the original Tenant
named under this Lease in the Basic Lease Information (A) is not in occupancy of
at least [...***...] of the entire Premises then demised hereunder,  or (B) does
not intend to remain in such  occupancy  (but  intends  to assign  this Lease or
sublet the  Premises  in whole or in part such that such  occupancy  requirement
will not be met),  or (C) does not  intend  to occupy  the  entire  First  Offer
Increment,  following  the  commencement  of the lease  term of the First  Offer
Increment,  then in any such case Tenant  shall have no right to lease the First
Offer  Increment  and  Tenant's  exercise of its right of first offer as to such
First  Offer  Increment  shall be null and void.  Tenant's  right of first offer
shall not be  applicable  during  the last one (1) year of the Term  unless  and
until Tenant shall validly  exercise its renewal option,  in which case Tenant's
right of first offer shall terminate one (1) year prior to the expiration of the
renewal term (unless earlier terminated as provided herein).

41.  Expansion Option.

         a. Tenant  shall have an option (the  "Expansion  Option") to lease the
ground floor of Building C of the Property (the "Expansion  Space"), as shown on
Exhibit A attached hereto,  pursuant to the terms and conditions of this Section
41. Tenant shall  exercise the Expansion  Option,  if at all, by written  notice
("Tenant's  Expansion  Notice")  thereof to  Landlord  on or prior to January 1,
2000. If Tenant does not timely exercise the Expansion  Option,  it shall expire
and be of no force or effect,  Landlord  shall be released of its  obligation to
offer or lease the Expansion Space to Tenant pursuant to this Section 41, Tenant
shall have no rights with respect  thereto  pursuant to this Section 41, and the
provisions of this Section 41 shall terminate.

         b. Upon Tenant's timely exercise of the Expansion Option,  Landlord and
Tenant  shall  promptly  enter into an  amendment  of this  Lease,  adding  such
Expansion  Space to the  Premises on all the terms and  conditions  set forth in
this Lease as to the Premises then demised  hereunder,  except that (i) the term
of the lease to Tenant of the  Expansion  Space shall  commence on the date (the
"Expansion Space Commencement Date") specified in Tenant's Expansion Notice, but
in no event  shall  such  date be  earlier  than  thirty  (30)  days  after  the
Commencement  Date for the Phase II  Premises  or later than  [...***...],  and,
subject to Section 41.c.  below,  Landlord shall deliver the Expansion  Space to
Tenant on such date with Landlord's Base Shell Work completed therein,  (ii) the
initial  monthly  Base Rent  payable by Tenant  for the  Expansion  Space  shall
commence [...***...] days after the Expansion Space Commencement Date, and shall
be the fair market rent for such space,  as defined in Section 39 above,  except
that such Base Rent  commencement  date and the other provisions of this Section
41 applicable to the Expansion  Space shall be taken into account in determining
such fair market rent (and such rent shall be subject to  adjustment at the same
time and in the same  manner as the Base Rent for the  balance  of the  Premises
pursuant to Section 4.b. of this Lease),  (iii) Tenant's  Percentage Share shall
be  increased  to take into  account the  Expansion  Space (such  increase to be
determined by dividing the rentable  square footage of such  Expansion  Space by
the rentable  square  footage of the  Buildings (as set forth in the Basic Lease
Information). Without limitation of the foregoing, (x) the provisions of Section
4.a. above regarding the  commencement of Base Rent shall apply to the Expansion
Space,  with each  reference  therein to a Phase

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being deemed a reference  to the  Expansion  Space,  and (y) the  provisions  of
Exhibit B to this Lease governing the Tenant  Improvements  shall fully apply to
the Expansion  Space,  except that Landlord's  Contribution  with respect to the
Expansion  Space shall be  $[...***...]  (which equals  $[...***...]  per agreed
rentable  square  foot of the  Expansion  Space).  The fair  market rent for the
Expansion  Space shall be mutually agreed upon by Landlord and Tenant in writing
within the  thirty  (30)-day  period  commencing  three (3) months  prior to the
Expansion  Space  Commencement  Date. If Landlord and Tenant are unable to agree
upon the fair market rent within  such  thirty  (30)-day  period,  then the fair
market rent shall be established by appraisal in accordance  with the procedures
set forth in Exhibit E to this Lease.  If the fair market  monthly  rent for the
Expansion Space has not been  established  prior to the date Base Rent commences
with  respect  thereto,  then  Tenant  shall  pay as  monthly  Base Rent for the
Expansion  Space the amount  produced by multiplying the rentable square footage
of the  Expansion  Space by the Rent Floor (as  defined  below) and, if the fair
market monthly rent, as subsequently determined, exceeds the rent paid by Tenant
for the  Expansion  Space  during the period  prior to the date the fair  market
monthly rent was determined,  Tenant shall pay the deficiency to Landlord within
ten (10)  days  after  such  determination,  and if the  fair  market  rent,  as
subsequently determined, is less than the rent so paid by Tenant, Landlord shall
credit  Tenant's   overpayment  against  Tenant's  next  accruing  monthly  Rent
obligations with respect to the Premises. As used herein, "Rent Floor" means the
Base Rent payable by Tenant (for all of the Premises then leased hereunder),  as
calculated on an average basis per rentable square foot of the Premises, for the
full calendar month  immediately  preceding the calendar month in which the Base
Rent for the Expansion Space  commences  (without giving effect to any temporary
rent abatements then in effect).

         c.  If  Tenant  exercises  the  Expansion  Option,  Landlord  does  not
guarantee  that the  Expansion  Space will  delivered to Tenant in the condition
required  hereunder on the date specified in Tenant's  Expansion Notice pursuant
to Section  41.b.  above.  In the event of any  delivery  after  such  date,  as
Tenant's sole recourse,  the term of this Lease as to the Expansion  Space shall
be delayed  until the date  Landlord  legally  delivers  the same to Tenant with
Landlord's Base Shell Work completed therein.

         d.  Notwithstanding  the  foregoing,  if as of  the  date  of  Tenant's
exercise of its Expansion Option, or the date immediately preceding the date the
lease term of the  Expansion  Space is to commence,  (i) Tenant is in default of
any of its obligations under this Lease, or (ii) the original Tenant named under
this Lease in the Basic Lease  Information  (A) is not in  occupancy of at least
[...***...]  of the entire  Premises  then  demised  hereunder,  or (B) does not
intend to remain in such  occupancy  (but intends to assign this Lease or sublet
the Premises in whole or in part such that such occupancy  requirement  will not
be met), or (C) does not intend to occupy the entire Expansion Space,  following
the commencement of the lease term of the Expansion Space, or (D) has not leased
the Phase II Premises pursuant to this Lease, then in any such case Tenant shall
have no right  to  lease  the  Expansion  Space  and  Tenant's  exercise  of the
Expansion Option shall be null and void.

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42.  Licensed Area.

         a. As used  herein,  the  iLicensed  Areai  shall mean a portion of the
Common Areas between  Buildings B and C, containing  approximately  1,700 square
feet, in a location reasonably approved by Landlord;  the "Generator" shall mean
a [...***...]  reasonably approved by Landlord;  and the "Generator  Facilities"
shall mean the  [...***...],  all as reasonably  approved by Landlord,  together
with any fuel or other Hazardous Materials contained therein.  The Licensed Area
shall  not be part of the  Premises  for any  purposes  of the  Lease;  however,
certain  provisions  of the Lease shall apply to the Licensed Area as if it were
part of the Premises, as more particularly set forth below.

                  Landlord  hereby grants to Tenant,  as an  appurtenance to the
Premises,  and for the term of the Lease  (subject  to  earlier  termination  as
hereinafter  set forth),  the right to use the Licensed Area, for the purpose of
installing,   maintaining   and   operating  the  Generator  and  the  Generator
Facilities,  all in accordance with the remaining provisions of this Section 42.
Tenant  accepts the Licensed Area in its "as-is"  condition.  Landlord  makes no
representations respecting the Licensed Area or its suitability for operation of
the Generator Facilities.

                  Tenant   shall  have  the  right  to  install  the   Generator
Facilities in  accordance  with plans and  specifications  approved by Landlord,
such  approval  not to be  unreasonably  withheld.  Such  installation  (and any
subsequent  maintenance  or testing  activities  with  respect to the  Generator
Facilities) shall be governed by the provisions of Section 9 of this Lease (with
each reference  therein to the Premises being deemed a reference to the Licensed
Area), except that if the Generator  Facilities are installed  concurrently with
the Tenant Improvements,  the provisions of Exhibit B shall apply thereto to the
extent  inconsistent with said Section 9. Landlord  expressly reserves the right
to require that any installation, maintenance or testing activities be conducted
at times  other  than  normal  business  hours of the  Property,  so as to avoid
interference  with the activities of other  occupants of the Property.  Landlord
also reserves the right to require Tenant to install and maintain throughout the
term of the Lease such  landscaping  in or about the  Licensed  Area as Landlord
shall require to hide the Generator  Facilities from view and otherwise create a
sightly condition consistent with the character of the balance of the Property.

                  Tenant  shall not  commence any  installation  or  maintenance
activities (or engage in any use of the Generator) until Tenant has demonstrated
to Landlordis  reasonable  satisfaction that Tenant has obtained (and that there
remain  in full  force  and  effect)  all  necessary  governmental  permits  and
approvals  (including,  without  limitation,  electrical  wiring  permits,  fuel
storage tank permits and the like) for the Generator Facilities.  If at any time
during the term of the Lease such permits or  approvals  shall expire and not be
renewed, or if applicable laws, orders,  rules,  regulations or ordinances shall
otherwise  not permit the  Generator  Facilities to remain or be operated in the
Licensed  Area, or if there shall be any release of Materials  upon the Licensed
Area or any other portion of the Property (or upon adjacent  lands)  arising out
of or in connection with the Generator Facilities,  Tenant shall promptly remove
the  Generator  Facilities  in accordance  with the  provisions  set forth below
applicable to Tenant's  removal of the Generator  Facilities upon the expiration
or earlier termination of the Lease.

                  The  provisions  of Section  13.a.  of this Lease  shall fully
apply to Tenant's use of the Licensed Area and the installation, maintenance and
operation of the Generator Facilities,  all as if each reference in said Section
13.a.  to the  "Premises"  were a  reference  to the  "Licensed  Area".  Without
limitation,  the parties  recognize that wiring,  conduits and other elements of
the  Generator  Facilities  may

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*    Confidential Treatment Requested

                                       34

<PAGE>


run from the Licensed Area through other Common Areas and/or  tenanted  areas of
the Property; and Tenant expressly agrees to indemnify, defend and save harmless
Landlord and the other Indemnitees from and against all loss, costs,  penalties,
liability,  damage and claims of  whatever  nature  arising  (or claimed to have
arisen) from the installation, maintenance and operation of such wires, conduits
and other facilities.

                  Tenant   shall  have  the  right  to  operate  the   Generator
Facilities so as to provide electrical power to the Premises.  However, (i) such
right shall be exercised only when (and for so long as) the supply of electrical
service  to the  Premises  in the  ordinary  manner has been  interrupted  or as
necessary to test the Generator  Facilities,  and (ii) Tenant shall not sell the
electrical services of the Generator  Facilities to any other party or otherwise
use the Generator  Facilities to provide electrical  services to any other party
or to any other portion of the Property.

                  A fire  or  other  casualty  or a  taking  by  eminent  domain
affecting  the Licensed Area or the  Generator  Facilities  shall not affect the
rights and obligations of Tenant under the Lease,  and the Lease shall remain in
full force and effect,  without any abatement of any amounts payable to Landlord
thereunder.  Landlord shall be entitled to all  compensation,  damages,  income,
rent  awards  and  interest  thereon  whatsoever  which  may be  paid or made in
connection  with any taking of the Licensed Area, and Tenant shall have no claim
against  Landlord or any  governmental  authority for the value of any unexpired
term of its rights to the Licensed Area; provided,  however,  that the foregoing
shall not prohibit  Tenant from  prosecuting a separate claim against the taking
authority for an amount separately designated for the Generator  Facilities,  so
long as any award to Tenant will not reduce the award to Landlord.

                  Throughout  the Term,  Tenant  shall  maintain  the  Generator
Facilities (including the fencing and landscaping surrounding the Licensed Area)
in a safe, operable and sightly condition, and observe all rules and regulations
promulgated by Landlord  pursuant to this Lease,  as applicable to the Generator
Facilities and Tenant's use and maintenance  thereof.  The Generator  Facilities
shall be and remain Tenant's property throughout the term of the Lease, and upon
the  expiration  or earlier  termination  of the Lease,  Tenant shall remove the
Generator Facilities, and shall restore the Licensed Area and all other portions
of the  Property  affected  by the  installation  and  removal of the  Generator
Facilities,   to  substantially  the  condition  which  existed  prior  to  such
installation and removal.

                  Landlord shall have the right,  from time to time, as required
by  applicable  Legal   Requirements,   to  require  Tenant  to  temporarily  or
permanently  relocate the Licensed Area to any other location  within the Common
Areas designated by Landlord. Such right shall be exercised by not less than one
hundred eighty (180) days prior written notice to Tenant, provided, however that
if applicable Legal  Requirements  shall require such relocation to be performed
prior to the  expiration  of one  hundred  eighty  (180) days  after  Landlord's
notice, then Landlord's required notice period shall be shortened to the longest
period allowable to comply with such Legal Requirements.  If such right shall be
exercised,  then  Tenant,  at its sole  cost and  expense,  shall  relocate  the
Generator  and all other  Generator  Facilities  to the location  designated  by
Landlord on or prior to the  expiration  of such thirty (30) day period (or such
longer  period  as  Landlord  shall set forth in its  relocation  notice).  Such
relocation  shall be performed by Tenant in  accordance  with all  provisions of
this Lease applicable to the  installation of the Generator  Facilities in their
original  location.  Tenant  acknowledges  that during any such  relocation  the
Generator  Facilities  will be unavailable for Tenant's use, and Tenant releases
Landlord and the other  Indemnitees  from any and all claims arising out of such
unavailability.

                  If Landlord  closes the Building and calls for its evacuation,
or suggests that the Building be evacuated for any reason,  including because of
an electrical failure, and if one or more employee,  agent,

                                       35

<PAGE>


contractor,  or other person  acting on behalf of or at the request of Tenant or
Tenant's  affiliate(s)  ("Tenant's  Personnel")  remains in or later  enters the
Building or the Premises during the evacuation period, then Tenant hereby waives
all claims  against  Landlord and its  constituent  owners,  agents,  employees,
officers and contractors (the  "Indemnitees")  for any injury incurred by any of
Tenant's Personnel,  or injury to property,  due in whole or in part to Tenant's
failure  to  evacuate  all of  Tenant's  Personnel  from  the  Premises  and the
Building. Further, Tenant will hold the Indemnitees harmless from and defend and
indemnify  them  against  any and all  claims,  liabilities,  damages  or costs,
including  reasonable  attorney's fees, incurred by them due to injury to person
or property as a direct or indirect  result of Tenant's  Personnel  remaining in
the Premises or the Building during such evacuation period.

                  To the maximum extent  practicable and applicable (but subject
to the other  provisions  set forth in this  Section  42),  the  obligations  of
Tenant,  and the  rights of  Landlord,  under the Lease  shall be applied to the
Licensed Area, all as if the Licensed Area were included in the Premises.

         b.  Tenant  shall  not use any  portion  of the  Licensed  Area for the
Handling of Hazardous  Materials  without the express  written  prior consent of
Landlord,  and then  only to the  extent  that  the  presence  of the  Hazardous
Materials is (i) properly licensed and approved by all appropriate  governmental
officials and in accordance with all applicable  Legal  Requirements and (ii) in
compliance with any terms and conditions  stated in said prior written  approval
by Landlord.  Tenant shall promptly  provide Landlord with copies of all notices
received by it, including, without limitation, any notice of violations,  notice
of  responsibility  or  demand  for  action  from  any  federal,  state or local
authority or official in connection with the presence of Hazardous  Materials in
or about the Licensed Area or any other portion of the Property. In the event of
any release of Hazardous  Materials  upon the Licensed Area or any other portion
of the Property, or upon adjacent lands, if caused by Tenant or any other Tenant
Party,  Tenant  shall  promptly  remedy  the  problem  in  accordance  with  all
applicable  Legal  Requirements.  The  provisions of Section 8.d. of this Lease,
including, without limitation,  Tenant's indemnification obligations thereunder,
shall fully apply to Tenantis  use of the  Licensed  Area and the  installation,
maintenance and operation of the Generator Facilities,  all as if each reference
in said Section 8.d. to the "Premises" were a reference to the "Licensed  Area".
The  provisions  of this Section  42.b.,  and the other  indemnities  granted by
Tenant in this Section 42, shall survive the  expiration or earlier  termination
of the Lease.

43.  General.

         a.  Captions.  The captions and headings used in this Lease are for the
purpose of  convenience  only and shall not be  construed to limit or extend the
meaning of any part of this Lease.

         b.  Time.  Time is of the  essence  for the  performance  of each term,
condition and covenant of this Lease.

         c. Severability.  If any provision of this Lease is held to be invalid,
illegal or unenforceable, the invalidity,  illegality, or unenforceability shall
not affect any other provision of this Lease,  but this Lease shall be construed
as if the invalid,  illegal or  unenforceable  provision had not been  contained
herein.

         d.  Choice of Law;  Construction.  This Lease  shall be  construed  and
enforced in accordance with the laws of the State of California. The language in
all parts of this Lease shall in all cases be 

                                       36

<PAGE>


construed  as a whole  according  to its fair  meaning and not  strictly  for or
against either Landlord or Tenant.

         e. Gender;  Singular,  Plural. When the context of this Lease requires,
the neuter  gender  includes the  masculine,  the  feminine,  a  partnership  or
corporation or joint venture, and the singular includes the plural.

         f. Binding Effect. The covenants and agreements contained in this Lease
shall be binding on the  parties  hereto  and,  subject to Section 14 above,  on
their respective successors and assigns.

         g. Waiver. The waiver of Landlord of any breach of any term,  condition
or covenant of this Lease shall not be deemed to be a waiver of the provision or
any  subsequent  breach of the same or any other term,  condition or covenant of
this Lease. The subsequent acceptance of Rent hereunder by Landlord shall not be
deemed to be a waiver of any  preceding  breach at the time of acceptance of the
payment.  No  covenant,  term or condition of this Lease shall be deemed to have
been waived by Landlord unless the waiver is in writing signed by Landlord.

         h. Entire  Agreement.  This Lease is the entire  agreement  between the
parties,  and  supersedes  all prior  agreements,  including  letters of intent,
between them, and there are no agreements or representations between the parties
except as expressly set forth herein.  Except as otherwise  provided herein,  no
subsequent  change or addition to this Lease shall be binding  unless in writing
and signed by the parties hereto.

         i. Waiver of Jury.  Tenant and Landlord hereby waive any right they may
have to a jury trial in the event of  litigation  between  Tenant  and  Landlord
pertaining  to this  Lease.  Landlord  and  Tenant  agree  that  this  paragraph
constitutes  a written  consent to waiver of trial by jury within the meaning of
California Code of Civil  Procedure  Section  631(a)(2),  and Tenant does hereby
authorize  and empower  Landlord to file this  paragraph  and or this Lease,  as
required,  with the clerk or judge of any court of competent  jurisdiction  as a
written consent to waiver of jury trial.

         j.  Counterparts.  This Lease may be executed in counterparts,  each of
which shall be an original,  and all of which together shall  constitute but one
instrument.

         k. Exhibits. The Basic Lease Information and all schedules and exhibits
attached hereto are hereby incorporated herein and made an integral part hereof.

         l.  Addendum.   The  Addendum,   if  any,  attached  hereto  is  hereby
incorporated herein and made an integral part hereof.

                                       37

<PAGE>


                  IN WITNESS  WHEREOF,  the parties have  executed this Lease on
the dates set forth below, effective as of the date first above written.


Landlord:                                          Tenant:

SimFirst, L.P.,  a California                      Lynx Therapeutics, Inc.,
limited partnership                                a Delaware corporation

By: Simeon Commercial Properties,
                                                   By: /s/ Sam Eletr
                                                       -------------------------
By:  /s/ Curt Setzer
     -------------------------                     Its:  Chief Executive Officer
                                                         & Chairman of the Board


Its: Vice President                                By: /s/ Ed Albini
    ---------------------------                        -------------------------
                                                   Its:  Chief Financial Officer

                                       38

<PAGE>


                                   SCHEDULE 1

                                    BASE RENT

PHASE I:

From the Phase I Rent  Commencement Date until the
day before the Phase II Rent Commencement Date:              $[...***...]

From the Phase II Rent  Commencement  Date through
the  day   before   the   Expansion   Space   Rent
Commencement  Date  or,  if the  Expansion  Option
shall   not   have   been    exercised,    through
[...***...]:                                                 $[...***...]

From the Expansion  Space Rent  Commencement  Date
or, if the  Expansion  Option  shall not have been
exercised,    from   [...***...],    through   the
expiration of the [...***...]  full calendar month
after the Phase I Rent Commencement Date:                    $[...***...]

From  the  first  day  of  the  [...***...]   full
calendar month after the Phase I Rent Commencement
Date  through the  expiration  of the  [...***...]
full  calendar   month  after  the  Phase  I  Rent
Commencement Date:                                           $[...***...]

Thereafter:                                                  As per Section 4.b.
                                                             of the Lease.

PHASE II:

From the Phase II Rent  Commencement  Date through
the  expiration of the  [...***...]  full calendar
month  after the Phase I Rent  Commencement  Date:           $[...***...]

From  the  first  day  of  the  [...***...]   full
calendar month after the Phase I Rent Commencement
Date through the  expiration  of the  thirty-sixth
full  calendar   month  after  the  Phase  I  Rent
Commencement Date:                                           $[...***...]

Thereafter:                                                  As per Section 4.b.
                                                             of the Lease.

EXPANSION SPACE:                                             As per Section 4.b.
                                                             of the Lease.


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*    Confidential Treatment Requested

<PAGE>


                                    EXHIBIT A
                              PREMISES DESIGNATION

                                  [MAP GRAPHIC]


<PAGE>


                                   EXHIBIT A-1

                               PROPERTY SITE PLAN

                                  [MAP GRAPHIC]


<PAGE>


                                    EXHIBIT B

                               TENANT IMPROVEMENTS

1.   Tenant Improvements.

         a.  Plans.  Improvements  shall  be  constructed  in  the  Premises  [n
accordance with this Paragraph 1. Prior to the  commencement of any construction
in the  Premises by Tenant,  Tenant  shall  furnish to Landlord  for  Landlord's
review and approval (which approval shall not be unreasonably withheld) detailed
layout  plans and finish  specifications  (the  "Space  Plans")  prepared  by an
architect reasonably  acceptable to Landlord.  The Space Plans shall show all of
the improvements which Tenant desires to be constructed in the Premises, and all
such  improvements  shall comply with all  applicable  building  codes and other
legal  requirements.   The  Space  Plans  shall  separately  note  any  proposed
structural work or  extraordinary or supplemental  electrical,  plumbing or HVAC
requirements, and shall contain such detail and specifications as would permit a
general contractor to obtain preliminary estimates of the cost of performing all
work shown thereon.  The Space Plans shall identify any "Iong4ead" materials (as
described in Paragraph 1.e.  below) then known by Tenant or Tenant's  architect.
Provided  that  Landlord  shall  have  received  copies of all prior  drafts and
interim copies of the proposed Space Plans,  Landlord shall respond to the Space
Plans within five (5) Business Days of its receipt thereof. Tenant shall respond
promptly to any  reasonable  objections of Landlord to the Space Plans and shall
resubmit appropriately revised Space Plans prepared by Tenant's architect within
ten (10) Business Days of Tenant's receipt of Landlord's  objections.  The Space
Plans, as finally  approved in writing by Landlord,  shall be referred to herein
as the  "Final  Space  Plans."  Within  thirty  (30)  days of the date  Landlord
approves in writing  the Space  Plans,  Tenant  shall  furnish to  Landlord  for
Landlord's  review  and  approval  (which  shall not be  unreasonably  withheld)
working plans and specifications, and a schedule and budget for the construction
(collectively, the "Working Drawings") prepared by Tenant's architect for all of
the  improvements  which Tenant desires to be  constructed in the Premises.  The
Working Drawings shall show  improvements  that conform to the Final Space Plans
(except  to  the  extent   specifically   noted   therein  or  in   accompanying
specifications)  and shall be in  sufficient  detail as to  enable  the  general
contractor  for the  work to  obtain  all  necessary  governmental  permits  for
construction  of all of  the  improvements  and to  secure  complete  bids  from
qualified  contractors  to perform  the work for all of the  improvements  to be
constructed  in the Premises.  Landlord  shall  respond to the Working  Drawings
within ten (10)  Business  Days of its receipt  thereof.  Tenant  shall  respond
promptly to any  reasonable  objections of Landlord to the Working  Drawings and
shall  resubmit  appropriately  revised  Working  Drawings  prepared by Tenant's
architect  within ten (10)  Business  Days of  Tenant's  receipt  of  Landlord's
objections.  (The  Working  Drawings,  as  approved in writing by  Landlord,  as
revised  by  Tenant  from  time to time  with  Landlord's  written  approval  in
accordance  with the following  provisions of this Paragraph 1, are  hereinafter
called the "Final  Plans",  and the  improvements  to be performed in accordance
with the Final Plans are hereinafter called the "Tenant Improvements").

         b. Construction by Tenant's Contractor. Landlord and Tenant acknowledge
that a general  contractor  selected  by Tenant  ("Tenant's  Contractor")  shall
construct the Tenant  Improvements.  The following provisions shall apply to the
construction:

                  i.  Approval.   Tenant's   Contractor   shall  be  subject  to
Landlord's  prior written  approval,  which approval  shall not be  unreasonably
withheld or delayed.

                  ii.   Qualifications.   Tenant's  Contractor  shall  (I)  have
substantial  recent  experience in the construction  of' tenant  improvements in
comparable  buildings in comparable  business parks in the



<PAGE>


greater San Francisco Bay Area,  (2) be licensed by the State of California  (as
evidenced by Tenant's  submission  to Landlord of' Tenant's  Contractor's  state
license number),  (3) utilize only union labor on the construction of the Tenant
Improvements, (4) have the capacity. to be bonded by a recognized surety company
to assure full  performance of the  construction  contract for the work shown on
the Final Plans (as evidenced by Tenant's submission to Landlord of a commitment
or other writing  satisfactory to Landlord issued by a recognized surety company
confirming that Tenant's Contractor is bondable for construction projects having
a  contract  price  not less than the  contract  price  under  the  construction
contract for the Tenant Improvements),  and (5) have the capacity to meet all of
the  requirements  of  Paragraph  1.d.iii.   below  (as  evidenced  by  Tenant's
submission to Landlord of documentation satisfactory to Landlord).

                  iii. Requirements. Tenant  shall be  responsible  for Tenant's
Contractor,  subcontractors,  suppliers and materialmen (A) obtaining Landlord's
prior written approval (which Landlord shall not unreasonably withhold or delay)
of all  subcontractors  and  labor to be  utilized  in the  performance  of such
construction  work,  (B)  obtaining  all  necessary   governmental  permits  and
approvals in connection with all construction work shown on the Final Plans (and
Landlord shall have no  responsibility  whatsoever in connection  with obtaining
the  same),  (c)  furnishing  to  Landlord,  prior  to the  commencement  of any
construction  in the  Premises,  certificates  evidencing  comprehensive  public
liability  insurance  with limits per  occurrence of not less than  $[...***...]
with an additional  $[...***...]  umbrella policy, and property damage insurance
with limits per  occurrence  of not less than  $[...***...],  covering  Tenant's
Contractor's  and  subcontractors'  operations  in the Premises and the Building
(including any liability arising out of work involving Hazardous  Materials) and
builders' risk insurance providing coverage in an amount equal to the full value
of the Tenant Improvements upon completion thereof, and with respect to all such
insurance naming Landlord as an additional insured,  and upon Landlord's request
also naming any or all of the  Indemnitees  (as defined in Section 13. a. of the
Lease)  as  additional  insureds,   (D)  performing  the  construction  work  in
accordance  with the  reasonable  standards and  procedures  which  Landlord may
promulgate  from time to time for the safe and orderly  progress of construction
(the "Construction  Procedures"),  and (E) performing the construction work in a
good and workmanlike manner and in accordance with applicable Legal Requirements
and in such manner as to preclude  disturbance of other tenants and occupants of
the Buildings and, with respect to any work the sound levels or other effects of
which would disturb other tenants or occupants of the Buildings, performing such
work during other than business hours. Landlord shall have no responsibility for
furnishing  any  security  services  in or about the  Building  or  Premises  to
safeguard  Tenant's  construction  of the Tenant  Improvements  or  materials in
connection therewith.

                  iv.   Construction:   Changes.   Prior  to   commencement   of
construction of the Tenant  Improvements Tenant shall enter into a contract with
Tenant's  Contractor for  construction of the Tenant  Improvements and deliver a
copy thereof to Landlord and Tenant shall cause Tenant's  Contractor to promptly
commence and diligently pursue to completion the Tenant Improvements. The Tenant
Improvements shall be constructed by Tenant's Contractor in conformance with the
Final Plans. In the event that Tenant shall desire any change in or to the Final
Plans,  is such change shall affect the  Building  Systems or the Base  Building
Components,  or  materially  alter the design  layout of the Premises  from that
previously approved by Landlord,  Tenant shall submit to Landlord for Landlord's
review and  written  approval a copy of the change  order  prepared  by Tenant's
architect  or Tenant's  Contractor  with  respect to such  Change  (the  "Change
Order"),  together with revised Working Drawings prepared by Tenant's  architect
incorporating  the requested change and clearly  identifying the same as such on
the revised Working Drawings.  Landlord shall not unreasonably withhold or delay
its approval of the Change Order


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*    Confidential Treatment Requested


<PAGE>


or revised  Working  Drawings,  provided,  however,  that Landlord shall have at
least five (5)  Business  Days  after  receipt  thereof  to review any  proposed
Change.  Upon  completion  of the Tenant  Improvements,  Tenant shall deliver to
Landlord "CAD" as-built plans of the Tenant Improvements.

                  v. Concurrent Work.  Landlord and Tenant acknowledge and agree
that the Premises  shall be delivered to Tenant for  construction  of the Tenant
Improvements  at  such  time  as  Landlord  shall  determine  after  substantial
completion  of  Landlord's  Base  Shell Work but prior to  completion  of all of
Landlord's Work (as such terms are defined below); provided, however, that in no
event shall  Landlord be required to deliver the  Premises to Tenant  until such
time as Landlord  shall  reasonably  determine that  construction  of the Tenant
Improvements will not likely delay or interfere with Landlord's Work or increase
the cost of Landlord's Work. Landlord and Tenant shall cooperate and cause their
respective  contractors to cooperate in coordinating their respective work so as
to allow  completion of the same in a timely and cost efficient  manner.  In the
event  of  irreconcilable   conflicts  regarding   scheduling  of  the  work  or
utilization of Building  resources in connection with the work,  Landlord's Work
shall have priority.

                  vi. Substantial  Completion.  "Substantial  Completion" of the
Tenant  Improvements  shall be  deemed  to have  occurred  when,  in  Landlord's
reasonable   judgment,   Tenant's   Contractor   has   substantially   completed
construction  of the Tenant  Improvements,  subject  only to the  completion  of
"Punch List Items".  Punch List Items shall mean incomplete or defective work or
materials in the Tenant Improvements which do not materially impair Tenant's use
of the Premises for the conduct of Tenant's business therein.

         c. Landlord's Work. Landlord shall perform the work to the Building and
the  Premises   identified  on  Schedules  I  attached   hereto   (collectively,
"Landlord's Work"). The portion of Landlord's Work required to construct a water
tight building shell (i.e. exterior walls, floor slabs, and roof) is referred to
herein as "Landlord's  Base Shell Work".  Landlord's  Work shall be performed at
Landlord's  sole cost and expense  (except for any costs  resulting  from Tenant
Delays) by such general contractor as Landlord shall determine.  Landlord's Work
shall be  performed  in a good and  workmanlike  manner and in  accordance  with
applicable  Legal   Requirements.   Tenant   acknowledges  that  the  plans  and
specifications  for  Landlord's  Work have been prepared on the basis of certain
information   previously   furnished  by  Tenant  with  respect  to  the  Tenant
Improvements,  and that any changes to  Landlord's  Work or increase in the cost
thereof  or delay in the  completion  thereof  required  by reason of the Tenant
improvements  shall  constitute  "Tenant Delays" as set forth below and shall be
Tenant's sole responsibility.

         d. Early Entry.  In the event that Landlord shall allow Tenant to enter
any portion of the Premises prior to the  commencement of the term of this Lease
as to such  portion,  for  purposes of  measuring or  inspecting  the  Premises,
Tenant's Contractor's  construction of the Tenant Improvements,  or for purposes
of  Tenant's  installation  of  furniture,  fixtures,  electronic  communication
equipment,  telephones  or  other  equipment,  or for any  other  purposes,  the
provisions of Section 13 of the Lease,  entitled Indemnity and Insurance,  shall
apply in full to such space, and Tenant shall be solely responsible for all such
furniture,  fixtures and equipment  and for any loss or damage  thereto from any
cause  whatsoever.  Such  early  access  shall be  granted  in  Landlord's  sole
discretion.  Without  limitation,  in no event  will  Landlord  grant such early
access or  installation if Landlord shall determine that the same might delay or
interfere with Landlord's Work or increase the cost of Landlord's Work.

         e. Tenant  Delays.  Tenant shall be  responsible  for, and shall pay to
Landlord,  any and all costs and  expenses  (including  lost rent)  incurred  by
Landlord  in  connection  with the  following,  or by reason of any delay in the
commencement or completion of Landlord's  Work or in Landlord's  timely



<PAGE>


delivery of any Phase of the Premises  caused by the following:  (i) the failure
of Tenant to submit the Space  Plans,  Final Space  Plans,  Working  Drawings or
Final  Plans to  Landlord  by the dates or within the time  periods set forth in
Paragraph  1.a.  above,  or the failure of the Space  Plans,  Final Space Plans,
Working Drawings or Final Plans to meet the applicable requirements of Paragraph
l.a.  above,  (ii) any  changes in the Space  Plans,  Working  Drawings or Final
Plans,  after  submission  thereof to  Landlord  (including  any costs or delays
resulting from proposed changes that are not ultimately made), (iii) any failure
by Tenant to promptly  respond to inquiries  regarding the  construction  of the
Tenant Improvements or Landlord's Work or to promptly grant Tenant's approval of
materials or finishes for the Tenant  Improvements or Landlord's  Work, (iv) any
failure by Tenant to timely pay any amounts due from Tenant  hereunder (it being
acknowledged  that if  Tenant  falls to make or  otherwise  delays  making  such
payments, Landlord may stop Landlord's Work rather than incur costs which Tenant
is  obligated  to fund but has not yet done so and any  delay  from  such a work
stoppage  will be a Tenant  Delay),  (v) any failure of Tenant's  Contractor  to
promptly  commence and diligently  pursue to completion the Tenant  Improvements
after  Landlord's  delivery of the Premises to Tenant,  (vi) any interference by
Tenant  with the  construction  of  Landlord's  Work,  or (vii) any other  delay
requested or caused by Tenant, including,  without limitation,  any delay caused
by Tenant's  early entry into any  portion of the  Premises  pursuant to Section
2.d. of the Lease.  Each of the foregoing is referred to herein and in the Lease
as a "Tenant Delay".

                  Landlord  shall  notify  Tenant in writing of any Tenant Delay
(identifying  the nature of the Tenant Delay) as soon as reasonably  practicable
after  Landlord  becomes  actually  aware of such Tenant  Delay,  together  with
Landlord's  then good faith  estimate  of the  probable  duration of such Tenant
Delay.

         f. Cost of Improvements.  The cost of the construction and installation
of the Tenant Improvements shall be borne as follows:

                  i. Landlord  shall pay the entire cost of Landlord's  Work (as
described in Paragraph l.c. above), including costs of obtaining permits for the
same.  Landlord  shall  also pay the  Improvement  Tax (as  defined  below')  in
connection with Landlord's Work and the Tenant Improvements, up to the amount of
$1.44 per rentable square foot of the Premises.

                  ii.   Tenant   shall  pay  the  entire   cost  of  the  Tenant
Improvements (including,  without limitation, the Construction Operations Fee as
described in Paragraph 1.f.ii.C.  below, costs of permits and other governmental
fees,  and the  portion of the City of  Hayward  Interim  Supplemental  Building
Construction and Improvement Tax (the "Improvement  Tax") in excess of $1.44 per
rentable  square  foot of the  Premises),  except  that in  addition to the sums
referenced in clause i. above,  Landlord shall contribute  toward the total cost
of the construction and installation of the Tenant Improvements an amount not to
exceed the  product of  [...***...]  times the number of  rentable  square  feet
comprising the Rentable Area of the Premises  ("Landlord's  Contribution").  The
following provisions shall govern the payment of Landlord's Contribution:

              A. Disbursement  Schedule:  Installments.  Landlord shall disburse
Landlord's  Contribution in two  installments.  The first  installment  shall be
disbursed at the  mid-point of the schedule for the  construction  of the Tenant
Improvements.  The second  installment  shall be disbursed on  completion of the
Tenant  Improvements,  but in no event prior to the date on which  Tenant  shall
commence  paying rent under the Lease.  Landlord's  obligation  to disburse each
installment shall be further subject to the following conditions.


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              B.  Disbursement  of  Landlord's   Contribution.   Landlord  shall
disburse Landlord's Contribution directly to Tenant's Contractor,  and/or to the
applicable  subcontractors,  and/or to Tenant, as Landlord shall determine, upon
receipt of (x)  invoices of Tenant's  Contractor  to be furnished to Landlord by
Tenant  covering work actually  performed,  construction  in place and materials
incorporated  into  the  construction  (as  may  be  applicable)  describing  in
reasonable detail such work,  construction  and/or  materials,  (y) lien waivers
executed by Tenant's Contractor, subcontractors or suppliers, as applicable, for
their  portion  of  the  work  covered  by  the  requested  disbursement  and by
Landlord's  previous  disbursements  (all  such  waivers  to  be  in  the  forms
prescribed by California  Civil Code Section 3262).  No payment will be made for
materials or supplies not  incorporated  into the  construction,  regardless  of
whether the  materials  or supplies  are located on the  Premises.  Landlord may
withhold the amount of any and all retentions provided for in original contracts
or  subcontracts  until  expiration of the applicable lien periods or Landlord's
receipt of  unconditional  lien waivers and full releases upon final payment (in
the form  prescribed  by  California  Civil Code  Section  3262)  from  Tenant's
Contractor and all subcontractors and suppliers.

              C.  Construction  Operations  Fee.  Landlord shall retain from the
amount of Landlord's  Contribution,  in the manner described below, an aggregate
sum equal to [...***...] of the total cost of the  construction and installation
of the Tenant  Improvements  (which cost of the  construction  and  installation
shall.  include  architectural and engineering fees but shall not include permit
fees or the Improvement Tax) (the "Construction Operations Fee") as compensation
to Landlord for review of plans,  specifications  and budgets,  coordinating the
schedule for construction of the Tenant  Improvements with any other work to the
Building  or other  tenants'  premises  therein,  review  and  qualification  of
Tenant's  Contractor for work in the Building,  monitoring Tenant's and Tenant's
Contractor's  compliance with the Construction  Procedures (but without limiting
Tenant's liability for any  noncompliance),  and for other  miscellaneous  costs
incurred  by  Landlord  as a  result  of the  construction  work  not  otherwise
reimbursable  by Tenant  hereunder.  Other costs  reimbursable  by Tenant  shall
include, without limitation, the reasonable out of pocket costs paid by Landlord
to its architect and engineer to review the plans and  specifications  submitted
by Tenant pursuant to the foregoing  provisions.  At the time Landlord makes any
disbursement of Landlord's  Contribution,  Landlord shall retain from Landlord's
Contribution,  as a partial payment of the Construction Operations Fee and other
reimbursable  costs, a proportionate  amount of the Construction  Operations Fee
and such costs based upon Landlord's  reasonable estimate of the amount required
to be  withheld  from  such  disbursement  in order to  ensure  that the  entire
Construction  Operations  Fee and such  costs are  retained  over the  course of
construction  on a prorata basis.  At such time as Landlord's  Contribution  has
been  entirely  disbursed,   if  the  entire  Construction  Operations  Fee  and
reimbursable  costs  have not yet been  paid to  Landlord,  Tenant  shall pay to
Landlord  a prorate  portion  of each  payment  made by Tenant on account of the
Tenant  Improvements  in order to ensure  that the  balance of the  Construction
Operations  Fee and  such  costs  are  paid  to  Landlord  over  the  course  of
construction on a prorata basis.

              D. Certain  Costs.  Portions of  Landlord's  Contribution  may, at
Tenant's election,  be applied toward Tenant's  architectural fees in connection
with the design and construction of the Tenant Improvements, including the costs
of producing  the Space  Plans,  Working  Drawings  and Final  Plans;  provided,
however that the portion of Landlord's Contribution applied to such fees may not
exceed  [...***...]  per  rentable  square  foot  of the  Rentable  Area  of the
applicable Phase of the Premises.  Landlord shall reimburse Tenant for such fees
(or, if Tenant so notifies  Landlord in writing,  will make payments directly to
Tenant's architect, engineer or vendor) within thirty (30) days after Landlord's
receipt of copies of  receipted  invoices  and such other  evidence  as Landlord
shall  reasonably  require  coveting the same, but


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in no event prior to the date Tenant shall commence  construction  of the Tenant
Improvements. In no event may any portions of Landlord's Contribution be applied
towards the costs of Tenant's engineering fees, or personal property,  equipment
or furniture, or towards rent due under this Lease.

              E.  Entire  Premises  to be  Improved.  Tenant  acknowledges  that
Landlord's  Contribution  is to be applied to the Tenant  Improvements  (and the
architectural  costs described  above) covering the entire  Premises.  If Tenant
does not improve the entire  Premises,  then,  without  limitation  of any other
rights or remedies  of  Landlord  hereunder,  Landlord's  Contribution  shall be
adjusted  on a prorata per  rentable  square foot basis to reflect the number of
rentable square feet actually being improved.

              F.  Evidence  of Costs.  No later than  ninety (90) days after the
Rent Commencement Date, Tenant shall deliver a final as-built cost budget of the
Tenant Improvements,  certified by an officer of Tenant,  together with evidence
of such costs such as receipts and construction invoices.

              G.   Provisions   Applicable   to  Phases.   Landlord  and  Tenant
acknowledge  that  the  Phase I  Premises  and the  Phase  II  Premises  will be
delivered and improved at different  times in accordance  with the provisions of
the Lease.  Accordingly,  the foregoing  provisions shall apply separately as to
each Phase of the  Premises,  and where the  foregoing  provisions  refer to the
"Premises",  such reference shall be deemed a reference to the applicable  Phase
of the Premises.



<PAGE>


                                   SCHEDULE I

Outline  Specification  prepared by Cabak Rooney Jordan  Associates for Mr. Eden
Business Park, Phase I dated October 18, 1997,  revised January 16, 1998 amended
as follows:

1.   [...***...].
2.   [...***...].
3.   [...***...].
4.   [...***...].
5.   [...***...].

Drawings  prepared by Cabak Rooney Jordan Associates for Mt. Eden Business Park,
Sheets A-l, 2, 10, 11, 12, 13, 17, 18.


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                                    EXHIBIT C

                          COMMENCEMENT DATE MEMORANDUM


LANDLORD:             ____________________________________

                      ____________________________________

TENANT:               ____________________________________

                      ____________________________________

LEASE DATE:           ____________________________________

PREMISES:             ____________________________________

                      ____________________________________

                      ____________________________________



Pursuant to Section 2.d. of the above-referenced Lease, the Commencement Date of
Phase __ of the Premises is hereby established  as_____________,  19__, the Rent
Commencement   Date  of  Phase  __  of  the   Premises  is  hereby   established
as_____________,  19__, and the Expiration Date for all of the Premises  demised
under the Lease is hereby established as _____________, 200_.


                      LANDLORD:


                      _______________________________
                      a _____________________________


                      By ____________________________
                        Its _________________________



                      TENANT:

                      _______________________________
                      a _____________________________


                      By ____________________________
                        Its _________________________


<PAGE>


                                    EXHIBIT D

                              RULES AND REGULATIONS



1. No sign, placard, picture,  advertisement,  name or notice shall be installed
or displayed  on any part of the outside or inside of the  Building  without the
prior written consent of Landlord.  Landlord shall have the right to remove,  at
Tenant's  expense  and  without  notice,  any sign  installed  or  displayed  in
violation of this rule.  All approved  signs or lettering on doors,  windows and
walls shall be printed,  painted,  affixed or inscribed at the expense of Tenant
by a person chosen by Landlord,  using  materials of Landlord's  choice and in a
style and format approved by Landlord.

2. The directory of the Building will be provided exclusively for the display of
the name and location of tenants, and Landlord reserves the right to exclude any
other names therefrom.  Tenant shall pay Landlord's standard charge for Tenant's
listing thereon and for any changes by Tenant.

3. Except as consented to in writing by Landlord or in accordance  with Building
standard improvements, no draperies,  curtains, blinds, shades, screens or other
devices shall be hung at or used in connection  with any window or exterior door
or doors of the  Premises.  No  awning  shall  be  permitted  on any part of the
Premises.  Tenant shall not place anything  against or near glass  partitions or
doors or windows which may appear unsightly from outside the Premises.

4. Tenant shall not obstruct any sidewalks,  halls,  lobbies,  passages,  exits,
entrances,  elevators or stairways of the Building. No tenant and no employee or
invitee of any tenant shall go upon the roof of the Building or make any roof or
terrace  penetrations.  Tenant  shall  not  allow  anything  to be placed on the
outside terraces or balconies without the prior written consent of Landlord.

5. No Tenant shall invite to the  Premises,  or permit the visit of,  persons in
such numbers or under such conditions as to interfere with the use and enjoyment
of the Common Areas of the Building by other tenants.

6.   Intentionally Deleted.

7. Landlord will furnish Tenant,  free of charge, two (2) keys to Tenant's suite
entrance.  Landlord may make a reasonable charge for any additional keys and for
having any locks  changed.  Tenant shall not make or have made  additional  keys
without Landlord's prior written consent, and Tenant shall not alter any lock or
install  a new  additional  lock  or bolt on any  door of its  Premises  without
Landlord's  prior written  consent.  Tenant shall deliver to Landlord,  upon the
termination of its tenancy, the keys to all locks for doors on the Premises.  If
Tenant loses any keys furnished by Landlord,  Tenant shall pay Landlord the cost
of rekeying the Premises.

8.  If  Tenant  requires  telegraphic,  telephonic,  burglar  alarm  or  similar
services,  it shall first obtain, and comply with,  Landlord's  instructions for
their installation.

9. The  elevator  shall be  available  for use by all  tenants in the  Building,
subject to  reasonable  scheduling  as  Landlord  in its  discretion  shall deem
appropriate. No equipment, materials, furniture, packages, supplies, merchandise
or other  property  will be received in the  Building or carried in the elevator
except  between  the  hours,  in  the  manner  and in  the  elevators  as may be
designated by Landlord.



<PAGE>


10.  Tenant shall not place a load upon any floor of the Premises  which exceeds
the maximum load per square foot which the floor was designed to carry and which
is allowed by law.  Tenant's  business  machines and mechanical  equipment which
cause  noise or  vibration  which may be  transmitted  to the  structure  of the
Building or to any space therein,  and which is  objectionable to Landlord or to
any  tenants in the  Building,  shall be placed  and  maintained  by Tenant,  at
Tenant's  expense,  on vibration  eliminators  or other  devices  sufficient  to
eliminate noise or vibration.

11.  Tenant  shall  not use or  permit  to be used in the  Premises  any foul or
noxious gas or substance, or permit or allow the Premises to be occupied or used
in a manner  offensive or  objectionable  to Landlord or other  occupants of the
Building by reason of noise, odors or vibrations.  No animal,  except seeing eye
dogs or other  licensed  disability  assist animals when in the company of their
masters, may be brought into or kept in the Building.

12.  Tenant shall not use any method of heating or  air-conditioning  other than
that supplied by Landlord,  unless Tenant  receives the prior written consent of
Landlord.

13.  Tenant shall  cooperate  fully with  Landlord to assure the most  effective
operation of the Building's heating and  air-conditioning and to comply with any
governmental energy-saving rules, laws or regulations of which Tenant has actual
notice.  Tenant shall refrain from attempting to adjust controls other than room
thermostats installed for Tenant's use.

14. All entrance  doors to the  Premises  shall be left locked when the Premises
are not in use, and all doors opening to public  corridors  shall be kept closed
except for normal ingress and egress to and from the Premises.

15.  Landlord  reserves  the  right,  exercisable  without  notice  and  without
liability to Tenant, to change the name and street address of the Building.

16. Landlord  reserves the right to exclude any person from the Building between
the hours of 6:00 p.m.  and 7:00 a.m. the  following  day, or any other hours as
may be established from time to time by Landlord, and on Saturdays,  Sundays and
legal holidays,  unless that person is known to the person or employee in charge
of the  Building  and has a pass or is  properly  identified.  Tenant  shall  be
responsible  for all persons for whom it requests  passes and shall be liable to
Landlord for all acts of those persons. Landlord shall not be liable for damages
for any error in admitting or excluding any person from the  Building.  Landlord
reserves the right to prevent  access to the Building by closing the doors or by
other  appropriate  action in case of invasion,  mob, riot, public excitement or
other commotion.

17.  Tenant shall close and lock the doors of its  Premises,  shut off all water
faucets or other  water  apparatus  and turn off all lights and other  equipment
which is not required to be  continuously  run.  Tenant shall be responsible for
any damage or injuries  sustained by other  tenants or occupants of the Building
or Landlord for noncompliance with this Rule.

18. The toilet rooms, toilets, urinals, wash bowls and other apparatus shall not
be used for any purpose other than that for which they were constructed,  and no
foreign substance of any kind whatsoever shall be placed therein. The expense of
any breakage, stoppage or damage resulting from any violation of this rule shall
be borne by the tenant who, or whose  employees or  invitees,  shall have caused
it.



<PAGE>


19. Tenant shall not install any radio or  television  antenna,  loudspeaker  or
other  device on the roof or exterior  walls of the  Building.  Tenant shall not
interfere  with radio or  television  broadcasting  or reception  from or in the
Building or elsewhere.

20. Tenant shall not cut or bore holes for wires in the partitions,  woodwork or
plaster of the Premises.  Tenant shall not affix any floor covering to the floor
of the  Premises in any manner  except as approved by Landlord.  Landlord  shall
approve in writing the method of  attachment  of any  objects  affixed to walls,
ceilings or doors in the Premises.  Tenant shall repair,  or be responsible  for
the cost of repair of any damage resulting from noncompliance with this Rule.

21. Tenant shall not install,  maintain or operate upon the Premises any vending
machine  (other than  vending  machines  primarily  intended for use by Tenant's
employees) without the prior written consent of Landlord.

22.  Canvassing,  soliciting  and  distributing  handbills or any other  written
material  and peddling in the  Building  are  prohibited,  and each tenant shall
cooperate to prevent these activities.

23. Landlord reserves the right to exclude or expel from the Building any person
who, in Landlord's judgment,  is intoxicated or under the influence of liquor or
drugs,  or who is in  violation  of any of  the  Rules  and  Regulations  of the
Building.

24.  Tenant shall store all its trash and garbage  within its  Premises.  Tenant
shall not place in any trash box or  receptacle  any  material  which  cannot be
disposed of in the ordinary and customary  manner of trash and garbage  disposal
within the Building. All garbage and refuse disposal shall be made in accordance
with directions issued from time to time by Landlord.

25. Use by Tenant of  Underwriters'  Laboratory  approved  equipment for brewing
coffee,  tea, hot chocolate and similar  beverages and microwaving food shall be
permitted,  provided  that  the  equipment  and use is in  accordance  with  all
applicable federal,  state, county and city laws, codes,  ordinances,  rules and
regulations.

26.  Tenant  shall not use the name of the  Building  in  connection  with or in
promoting or  advertising  the business of Tenant,  except as Tenant's  address,
without the written consent of Landlord.

27.  Tenant  shall  comply  with all  safety,  fire  protection  and  evacuation
procedures and regulations  established by Landlord or any governmental  agency.
Tenant shall be responsible for any increased insurance premiums attributable to
Tenant's use of the Premises, Building or Property.

28. Tenant assumes any and all  responsibility  for protecting its Premises from
theft and robbery, which responsibility  includes keeping doors locked and other
means of entry to the Premises closed.

29. Tenant shall not use the Premises,  or suffer or permit  anything to be done
on, in or about the Premises, which may result in an increase to Landlord in the
cost of insurance maintained by Landlord on the Building and Common Areas.

30. Tenant's  requests for assistance will be attended to only upon  appropriate
application to the office of the Building by an authorized individual. Employees
of Landlord  shall not perform any work or do anything  outside of their regular
duties  unless under  special  instructions  from  Landlord,  and no employee



<PAGE>


of Landlord will admit any person  (Tenant or  otherwise) to any office  without
specific instructions from Landlord.

31.  Tenant  shall not park its  vehicles in any  parking  areas  designated  by
Landlord  as areas for parking by  visitors  to the  Building or other  reserved
parking  spaces.  Tenant shall not leave vehicles in the Building  parking areas
overnight,  nor park any  vehicles  in the  Building  parking  areas  other than
automobiles,   motorcycles,   motor  driven  or  non-motor  driven  bicycles  or
four-wheeled trucks.  Tenant, its agents,  employees and invitees shall not park
any one (1) vehicle in more than one (1) parking space.

32. The  scheduling  and manner of all Tenant  move-ins and  move-outs  shall be
subject to the reasonable discretion and approval of Landlord, and unless Tenant
occupies  the entire  Building in which the move is taking  place,  move-ins and
move-outs shall take place only after 6:00 p.m. on weekdays,  on weekends, or at
other times as Landlord may reasonably designate.  Landlord shall have the right
to approve or disapprove  the movers or moving company  employed by Tenant,  and
Tenant  shall  cause  the  movers  to use only the  entry  doors  and  elevators
designated by Landlord. If Tenant's movers damage the elevator or any other part
of the Property,  Tenant shall pay to Landlord the amount required to repair the
damage.

33. The Premises shall not be used for the storage of  merchandise,  for washing
clothes, for lodging or for any improper, objectionable or immoral purpose.

34.  Tenant shall not use in any space or in the public  halls of the  Building,
any hand trucks except those  equipped with rubber tires and side guards or such
other  material-handling  equipment as Landlord  may  approve.  Tenant shall not
bring any bicycles or other vehicles of any kind into the building.

35.  Landlord shall have the right to control and operate the public portions of
the Building, and the public facilities,  heating and air conditioning,  as well
as facilities  furnished for the common use of the tenants, in such manner as it
deems best for the benefit of the tenants generally.

36.  Landlord may waive any one or more of these Rules and  Regulations  for the
benefit  of Tenant  or any other  tenant,  but no  waiver by  Landlord  shall be
construed  as a waiver of the Rules  and  Regulations  in favor of Tenant or any
other  tenant,  nor prevent  Landlord  from  thereafter  enforcing the Rules and
Regulations against any or all of the tenants of the Building.

37. These Rules and  Regulations  are in addition to, and shall not be construed
to in any way  modify  or  amend,  in whole or in part,  the  terms,  covenants,
agreements and conditions of any lease of premises in the Building.

38. Landlord  reserves the right to make other  reasonable Rules and Regulations
as, in its  judgment,  may from time to time be needed for safety and  security,
for care and cleanliness of the Building and for the  preservation of good order
therein.  Tenant agrees to abide by all Rules and Regulations hereinabove stated
and any additional rules and regulations which are adopted.

39. Tenant shall be responsible for the observance of all of the foregoing rules
by Tenant's employees, agents, clients, customers, invitees and guests.



<PAGE>


                                    EXHIBIT E

                               APPRAISAL PROCEDURE

         After the  expiration  of the thirty  (30)-day  period set forth in the
Lease for the mutual  agreement  of  Landlord  and Tenant as to the fair  market
rent, each party hereto,  at its cost, may engage a real estate appraiser to act
on its behalf in determining  the fair market rent.  The  appraisers  each shall
have at least five (5)  years'  experience  in  brokering  or valuing  leases in
comparable  business parks in the Comparable Market and shall submit to Landlord
and Tenant in advance  for  Landlord's  and  Tenant's  reasonable  approval  the
appraisal  methods to be used.  If a party  appoints  such an appraiser  and the
other party fails to appoint  such an appraiser  within  fifteen (15) days after
notice  from the  first  party  that  the  first  party  has  appointed  such an
appraiser,  the single appraiser appointed shall be the sole appraiser and shall
set the fair market rent. If the two  appraisers are appointed by the parties as
stated in this paragraph, such appraisers shall meet promptly and attempt to set
the fair market rent. If such  appraisers are unable to agree within thirty (30)
days after  appointment of the second  appraiser,  the appraisers  shall elect a
third appraiser meeting the  qualifications  stated in this paragraph within ten
(10)  days  after  the last  date the two  appraisers  are given to set the fair
market rent, except that if the higher of the two determinations is 105% or less
of the  amount  set forth in the lower  determination,  the  average  of the two
determinations  shall be the fair market rent and the third  appraiser shall not
be appointed.  Each of the parties  hereto shall bear one-half (1/2) the cost of
appointing  the third  appraiser  and of the third  appraiser's  fee.  The third
appraiser  shall be a person who has not  previously  acted in any  capacity for
either party.  The third  appraiser shall conduct his own  investigation  of the
fair market  rent,  and shall be  instructed  not to advise  either party of his
determination  of the fair  market  rent  except  as  follows:  When  the  third
appraiser has made his determination, he shall so advise Landlord and Tenant and
shall establish a date, at least five (5) days after the giving of notice by the
third  appraiser  to  Landlord  and  Tenant,  on  which he  shall  disclose  his
determination  of the fair market  rent.  Such  meeting  shall take place in the
third  appraiser's  office unless otherwise agreed by the parties.  After having
initialed a paper on which his  determination  of fair market rent is set forth,
the third appraiser shall place his  determination  of the fair market rent in a
sealed  envelope.  Landlord's  appraiser and Tenant's  appraiser  shall each set
forth their  determination of fair market rent on a paper,  initial the same and
place them in sealed envelopes. Each of the three envelopes shall be marked with
the name of the  party  whose  determination  is  inside  the  envelope.  In the
presence of the third  appraiser,  the  determination of the fair market rent by
Landlord's appraiser and Tenant's appraiser shall be opened and examined. If the
higher of the two  determinations is 105% or less of the amount set forth in the
lower  determination,  the average of the two  determinations  shall be the fair
market rent, the envelope  containing the  determination of the fair market rent
by the third  appraiser  shall be  destroyed  and the third  appraiser  shall be
instructed  not to disclose his  determination.  If either  party's  envelope is
blank,  or does  not  set  forth  a  determination  of  fair  market  rent,  the
determination of the other party shall prevail and be treated as the fair market
rent. If the higher of the two determinations is more than 105% of the amount of
the  lower   determination,   the  envelope  containing  the  third  appraiser's
determination  shall be opened.  The fair market rent shall be the rent proposed
by either  Landlord's  appraiser or Tenant's  appraiser  which is closest to the
determination of fair market rent by the third appraiser.



<TABLE> <S> <C>


<ARTICLE>                     5
<LEGEND>
     THIS SCHEDULE  CONTAINS SUMMARY  FINANCIAL  INFORMATION  EXTRACTED FROM THE
     QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
     ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED MARCH 31, 1998.
</LEGEND>
<MULTIPLIER>                                   1,000
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                              DEC-31-1998
<PERIOD-START>                                 JAN-01-1998
<PERIOD-END>                                   MAR-31-1998
<CASH>                                              15,379
<SECURITIES>                                         8,720
<RECEIVABLES>                                          350
<ALLOWANCES>                                             0
<INVENTORY>                                              0
<CURRENT-ASSETS>                                    24,612
<PP&E>                                               6,610
<DEPRECIATION>                                       2,709
<TOTAL-ASSETS>                                      30,309
<CURRENT-LIABILITIES>                                3,668
<BONDS>                                                  0
                                    0
                                              0
<COMMON>                                            74,357
<OTHER-SE>                                         (47,903)
<TOTAL-LIABILITY-AND-EQUITY>                        30,309
<SALES>                                                  0
<TOTAL-REVENUES>                                       814
<CGS>                                                    0
<TOTAL-COSTS>                                            0
<OTHER-EXPENSES>                                     4,334
<LOSS-PROVISION>                                         0
<INTEREST-EXPENSE>                                       0
<INCOME-PRETAX>                                         (8)
<INCOME-TAX>                                             0
<INCOME-CONTINUING>                                     (8)
<DISCONTINUED>                                           0
<EXTRAORDINARY>                                          0
<CHANGES>                                                0
<NET-INCOME>                                            (8)
<EPS-PRIMARY>                                        (0.00)
<EPS-DILUTED>                                        (0.00)
        


</TABLE>


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