LYNX THERAPEUTICS INC
DEF 14A, 1998-04-15
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
Previous: TBA ENTERTAINMENT CORP, 10KSB40, 1998-04-15
Next: WHITE RIVER CORP, 10-K405, 1998-04-15




                            SCHEDULE 14A INFORMATION

                  Proxy Statement Pursuant to Section 14(a) of
                      the Securities Exchange Act of 1934
                                (Amendment no. 1)


Filed by the Registrant                      [X]
Filed by a party other than the Registrant   [ ]

Check the appropriate box:                 
[ ]  Preliminary Proxy Statement           
[ ]  Confidential, for Use of the Commission Only (as permitted by
     Rule 14a-6(e)(2))                
[X]  Definitive Proxy Statement            
[ ]  Definitive Additional Materials       
[ ]  Soliciting Material Pursuant to       
     Rule 14a-11(c) or Rule 14a-12       

                            Lynx Therapeutics, Inc.
            ------------------------------------------------
            (Name of Registrant as Specified in Its Charter)


  ------------------------------------------------------------------------
  (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of filing fee (Check the appropriate box):

[X]  No fee required.
[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.


(1)  Title of each class of securities to which transactions applies:

- --------------------------------------------------------------------------------

(2)  Aggregate number of securities to which transactions applies:

- --------------------------------------------------------------------------------

(3)   Per unit price or other underlying value of transaction  computed pursuant
      to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is
      calculated and state how it was determined):

- --------------------------------------------------------------------------------

(4)   Proposed maximum aggregate value of transaction:

- --------------------------------------------------------------------------------

(5)   Total fee paid:

- --------------------------------------------------------------------------------

[ ]   Fee paid previously with preliminary materials.
- --------------------------------------------------------------------------------

[ ]   Check box if any part of the fee is offset as  provided  by  Exchange  Act
      Rule  0-11(a)(2)  and identify the filing for which the offsetting fee was
      paid  previously.  Identify the previous filing by registration  statement
      number, or the Form or Schedule and the date of its filing.

(1)   Amount previously paid:

- --------------------------------------------------------------------------------

(2)   Form, Schedule or Registration Statement No.:

- --------------------------------------------------------------------------------

(3)  Filing party:

- --------------------------------------------------------------------------------

(4)  Date filed:

- --------------------------------------------------------------------------------


<PAGE>


                             LYNX THERAPEUTICS, INC.
                              3832 Bay Center Place
                            Hayward, California 94545

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS
                           TO BE HELD ON MAY 18, 1998

TO THE STOCKHOLDERS OF LYNX THERAPEUTICS, INC.:

         NOTICE IS HEREBY GIVEN that the Annual Meeting of  Stockholders of Lynx
Therapeutics,  Inc., a Delaware  corporation  (the  "Company"),  will be held on
Monday,  May 18,  1998 at 1:00 p.m.,  local  time,  at the  Company's  principal
executive offices, located at 3832 Bay Center Place, Hayward,  California 94545,
for the following purposes:

         1. To elect  directors  to serve for the  ensuing  year and until their
            successors are elected.

         2. To approve the  Company's  1992 Stock  Option Plan,  as amended,  to
            increase the aggregate  number of shares of Common Stock  authorized
            for issuance under such plan by 600,000 shares and to add provisions
            with respect to Section 162(m) of the Internal Revenue Code of 1986,
            as amended.

         3. To approve the Company's 1998 Employee Stock Purchase Plan.

         4. To ratify the selection of Ernst & Young LLP as independent auditors
            of the Company for its fiscal year ending December 31, 1998.

         5. To  transact  such other  business as may  properly  come before the
            meeting or any adjournment or postponement thereof.

         The foregoing  items of business are more fully  described in the Proxy
Statement accompanying this Notice.

         The Board of  Directors  has fixed the close of  business  on March 23,
1998,  as the record  date for the  determination  of  stockholders  entitled to
notice  of and to  vote  at  this  Annual  Meeting  and  at any  adjournment  or
postponement thereof.

                                              By Order of the Board of Directors


                                              Edward C. Albini,
                                              Secretary

Hayward, California
April 13, 1998


- --------------------------------------------------------------------------------
ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON.  WHETHER
OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE,  DATE, SIGN AND RETURN
THE   ENCLOSED   PROXY  AS   PROMPTLY  AS  POSSIBLE  IN  ORDER  TO  ENSURE  YOUR
REPRESENTATION  AT THE MEETING.  A RETURN  ENVELOPE (WHICH IS POSTAGE PREPAID IF
MAILED IN THE UNITED  STATES) IS  ENCLOSED  FOR THAT  PURPOSE.  EVEN IF YOU HAVE
GIVEN YOUR PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE MEETING. PLEASE
NOTE, HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A BROKER, BANK OR OTHER
NOMINEE  AND YOU WISH TO VOTE AT THE  MEETING,  YOU MUST  OBTAIN FROM THE RECORD
HOLDER A PROXY ISSUED IN YOUR NAME.
- --------------------------------------------------------------------------------



<PAGE>

                              LYNX THERAPEUTICS, INC.
                              3832 Bay Center Place
                            Hayward, California 94545

                                 PROXY STATEMENT

                       FOR ANNUAL MEETING OF STOCKHOLDERS
                                  MAY 18, 1998


                 INFORMATION CONCERNING SOLICITATION AND VOTING

General

         The enclosed  proxy is solicited on behalf of the Board of Directors of
Lynx Therapeutics,  Inc., a Delaware corporation ("Lynx" or the "Company"),  for
use at the Annual  Meeting of  Stockholders  to be held on May 18, 1998, at 1:00
p.m., local time (the "Annual  Meeting"),  or at any adjournment or postponement
thereof,  for the purposes set forth  herein and in the  accompanying  Notice of
Annual  Meeting.  The Annual  Meeting  will be held at the  Company's  principal
executive  office,  3832 Bay Center  Place,  Hayward,  California.  The  Company
intends to mail this proxy  statement  and  accompanying  proxy card on or about
April 13, 1998, to all stockholders entitled to vote at the Annual Meeting.

Solicitation

         The  Company  will bear the  entire  cost of  solicitation  of  proxies
including preparation,  assembly,  printing and mailing of this proxy statement,
the proxy and any additional  information  furnished to stockholders.  Copies of
solicitation materials will be furnished to banks, brokerage houses, fiduciaries
and custodians  holding in their names shares of Common Stock beneficially owned
by others to  forward to such  beneficial  owners.  The  Company  may  reimburse
persons  representing  beneficial  owners  of Common  Stock  for their  costs of
forwarding   solicitation   materials  to  such  beneficial   owners.   Original
solicitation of proxies by mail may be  supplemented  by telephone,  telegram or
personal  solicitation by directors,  officers or other regular employees of the
Company. No additional compensation will be paid to directors, officers or other
regular employees for such services.

Voting Rights and Outstanding Shares

         Only  holders  of record of Common  Stock,  Series B  preferred  stock,
Series C preferred  stock, and Series D preferred stock at the close of business
on March 23,  1998,  will be  entitled  to  notice of and to vote at the  Annual
Meeting. At the close of business on March 23, 1998, the Company had outstanding
and entitled to vote  6,098,068  shares of Common Stock,  and 332,288  shares of
Series B preferred stock,  123,299 shares of Series C preferred stock and 40,000
shares of Series D preferred stock, each share of which is presently convertible
into ten shares of Common Stock. The holders of Common Stock, Series B preferred
stock, Series C preferred stock, and Series D preferred stock will vote together
as a class (on an  as-if-converted  to  Common  Stock  basis)  on each  proposal
described in this Proxy Statement. Each holder of record of Common Stock on such
date will be entitled to one vote for each share held on all matters to be voted
upon at the Annual Meeting.  Each holder of record of Series B preferred  stock,
Series C  preferred  stock,  and Series D  preferred  stock on such date will be
entitled to ten votes for each share held on all matters to be voted upon at the
Annual Meeting.

         All votes will be tabulated by the inspector of election  appointed for
the meeting,  who will  separately  tabulate  affirmative  and  negative  votes,
abstentions  and  broker  non-votes.  Abstentions  will be counted  towards  the
tabulation  of votes cast on proposals  presented to the  stockholders  and will
have the same effect as negative votes.  Broker  non-votes are counted towards a
quorum, but are not counted for any purpose in determining  whether a matter has
been approved.

Revocability of Proxies

         Any person giving a proxy pursuant to this  solicitation  has the power
to revoke it at any time  before it is voted.  It may be revoked by filing  with
the Secretary of the Company at the Company's  principal  executive office, 3832
Bay Center Place, Hayward, California 94545, a written notice of revocation or a
duly executed  proxy bearing a


                                       2.
<PAGE>

later date,  or it may be revoked by attending the meeting and voting in person.
Attendance at the meeting will not, by itself, revoke a proxy.

Stockholder Proposals

         Proposals  of  stockholders  that are  intended to be  presented at the
Company's  1999 Annual Meeting of  Stockholders  must be received by the Company
not later than December 14, 1998, in order to be included in the proxy statement
and proxy relating to that Annual Meeting.


                                   PROPOSAL 1

                              ELECTION OF DIRECTORS

         There are six nominees for the six Board positions presently authorized
in the Company's By-laws. Each director to be elected will hold office until the
next annual meeting of  stockholders  and until his successor is elected and has
qualified, or until such director's earlier death,  resignation or removal. Each
nominee listed below is currently a director of the Company.

         Shares  represented by executed  proxies will be voted, if authority to
do so is not withheld,  for the election of the six nominees named below. In the
event that any  nominee  should be  unavailable  for  election as a result of an
unexpected  occurrence,  such  shares  will be voted  for the  election  of such
substitute nominee as management may propose. Each person nominated for election
has agreed to serve if elected and  management has no reason to believe that any
nominee will be unable to serve.

         Directors  are elected by a plurality of the votes present in person or
represented by proxy and entitled to vote.


             MANAGEMENT AND THE BOARD OF DIRECTORS RECOMMEND A VOTE
                         IN FAVOR OF EACH NAMED NOMINEE.

Nominees
<TABLE>
         The names of the  nominees and certain  information  about them are set
forth below:
<CAPTION>
                                                     Principal Position                                Director
                    Name                             with the Company                      Age           Since
         --------------------------------            ----------------                      ---           -----
<S>                                                  <C>                                   <C>           <C>
         Sam Eletr, Ph.D.                            Chairman of the Board and             58            1992
                                                       Chief Executive Officer
         William K. Bowes, Jr.(1)                    Director                              71            1994
         Sydney Brenner, M.B., D. Phil.              Director                              70            1993
         James C. Kitch(1)                           Director                              50            1993
         Kathleen D. La Porte(2)                     Director                              36            1994
         Craig C. Taylor(2)                          Director                              47            1994
<FN>
         -------------------------------- 
         (1)      Member of the Audit Committee
         (2)      Member of the Compensation Committee
</FN>
</TABLE>


         Dr.  Eletr has served as  Chairman  of the Board of the  Company  since
February 1992 and resumed the position of Chief Executive Officer of the Company
in November 1996, a position he held from February 1992 through January 1996. In
1981, Dr. Eletr founded  Applied  Biosystems,  Inc.,  ("ABI") a manufacturer  of
instruments and consumables for life science research and related  applications,
now a  wholly-owned  subsidiary  of  Perkin  Elmer  Corporation,  and  served as
Chairman of the Board of  Directors  and in various  executive  positions at ABI
from its inception until March 1987. Dr. Eletr acted as a consultant to ABI from
September  1990 until July 1992,  during  which time he  undertook to assume the
leadership of the Company.


                                       3.
<PAGE>

         Mr. Bowes has served as a director of the Company  since March 1994. He
has  been a  general  partner  of  U.S.  Venture  Partners,  a  venture  capital
partnership,  since 1981.  He currently  serves as a director of Amgen,  Inc., a
biotechnology company, AMCC, an integrated circuit company, XOMA Corporation,  a
biotechnology  company, and one U.S. Venture Partners' privately owned portfolio
company.

         Dr. Brenner has served as a director of the Company since October 1993.
In July 1996,  he was  appointed  the  Director and  President of The  Molecular
Sciences Institute, a non-profit research institute in Berkeley,  California. In
September  1996,  he retired from his position of Honorary  Professor of Genetic
Medicine,  University of Cambridge Clinical School.  From 1986 to his retirement
in 1991, Dr.  Brenner  directed the Medical  Research  Council Unit of Molecular
Genetics.  He was a  member  of the  Scripps  Research  Institute  in La  Jolla,
California until December 1994.

         Mr. Kitch has served as a director of the Company  since  February 1993
and Secretary of Lynx from February 1992 to December  1997. He was a director of
ABI, Lynx's  predecessor,  from August 1986 to February 1993. He is a partner at
Cooley Godward LLP, a law firm which has provided legal services to the Company.

         Ms. La Porte has served as a director of the Company  since March 1994.
She is a general partner of the Sprout Group,  the venture capital  affiliate of
Donaldson,  Lufkin and Jenrette. From 1987 to 1993, Ms. La Porte was a principal
at  Asset  Management  Company.  She  currently  serves  as a  director  of Onyx
Pharmaceuticals,  Inc., a biotechnology  company, Fem Rx, Inc., a medical device
company, and several private companies.

         Mr. Taylor has served as a director of the Company since March 1994 and
as Acting  Chief  Financial  Officer  from July 1994 to April 1997.  He has been
active in venture capital since 1977 when he joined Asset Management Company. He
is a general  partner  of AMC  Partners  89 L.P.,  which  serves as the  general
partner of Asset  Management  Associates  1989 L.P., a private  venture  capital
partnership.  He  currently  serves as a director of Metra  BioSystems,  Inc., a
biotechnology company, Pharmacyclics, Inc., a biotechnology company, and several
private companies.

Board Committees and Meetings

         During  the  calendar  year  ended  December  31,  1997,  the  Board of
Directors  held  seven  meetings.  The  Board  has  an  Audit  Committee  and  a
Compensation Committee. The Board does not have a standing Nominating Committee.

         The Audit  Committee meets with the Company's  independent  auditors at
least  annually  to review  the  results  of the annual  audit and  discuss  the
financial  statements,  recommends to the Board the  independent  auditors to be
retained,  and receives and considers the accountants'  comments as to controls,
adequacy of staff and management  performance  and procedures in connection with
audit and financial controls.  The Audit Committee is composed of Messrs.  Bowes
and Kitch. It met one time during such calendar year.

         The Compensation Committee reviews and recommends salaries for officers
and key employees.  The  Compensation  Committee also serves as the Stock Option
Committee for the 1992 Stock Option Plan for the employees of the Company and in
that capacity approves employee stock option grants. The Compensation  Committee
is composed of two non-employee directors: Ms. La Porte and Mr. Taylor.

         During the calendar  year ended  December  31, 1997,  each Board member
attended  80% or more of the  aggregate  of the meetings of the Board and of the
committees on which he or she served, held during the period for which he or she
was a director or committee member, respectively.


                                       4.
<PAGE>


                                   PROPOSAL 2

             APPROVAL OF AN AMENDMENT TO THE 1992 STOCK OPTION PLAN


         In July 1992,  the Board of  Directors  of the  Company  (the  "Board")
adopted, and the stockholders  subsequently  approved,  the Company's 1992 Stock
Option Plan (the "1992 Plan"). As a result of a series of amendments,  there are
3,400,000 shares of the Company's  Common Stock (the "Common Stock")  authorized
for  issuance  under the 1992  Plan.  In May 1996,  the Board  adopted,  and the
stockholders  subsequently approved, an amendment to the 1992 Plan to extend the
term of the 1992 Plan until March 2006. At February 28, 1998,  options  covering
an aggregate of 3,053,255 shares,  less canceled shares, of the Common Stock had
been granted under the 1992 Plan,  and  approximately  346,745  shares  remained
available for future grants.

         In February  1998,  the Board  approved an  amendment to the 1992 Plan,
subject to  stockholder  approval,  to enhance the  flexibility  of the Board in
granting stock options to the Company's employees and consultants. The amendment
increases the number of shares  authorized for issuance under the 1992 Plan from
a total of  3,400,000  shares  to  4,000,000  shares.  The  Board  adopted  this
amendment  to ensure  that the Company  can  continue to grant stock  options to
employees and consultants at levels determined appropriate by the Board.

         In February  1998,  the Board also  amended  the 1992 Plan,  subject to
stockholder approval,  generally to permit the Company,  under Section 162(m) of
the Internal  Revenue Code of 1986, as amended (the  "Code"),  to continue to be
able to deduct as a business  expense certain  compensation  attributable to the
exercise of stock options  granted under the 1992 Plan.  Section 162(m) denies a
deduction to any publicly  held  corporation  for certain  compensation  paid to
specified  employees  in a  taxable  year to the  extent  that the  compensation
exceeds   $1,000,000  for  any  covered   employee.   See  "Federal  Income  Tax
Information"  below for a discussion of the  application of Section  162(m).  In
light of the Section 162(m)  requirements,  the Board has amended the 1992 Plan,
subject to  stockholder  approval,  to include a  limitation  providing  that no
employee may be granted  options  under the 1992 Plan during a calendar  year to
purchase in excess of 500,000 shares of Common Stock. Previously, no such formal
limitation was placed on the number of shares  available for option grants to an
employee.  In  addition,  the 1992  Plan was  amended,  subject  to  stockholder
approval,  to provide  that,  in the  Board's  discretion,  directors  who grant
options to covered employees generally will be "outside directors" as defined in
Section 162(m). For a description of this requirement, see "Administration."

         Stockholders are requested in this Proposal 2 to approve the 1992 Plan,
as amended. If the Stockholders fail to approve this Proposal 2, options granted
under  the  1992  Plan   after  the   annual   meeting   will  not   qualify  as
performance-based  compensation and, in some  circumstances,  the Company may be
denied a business expense  deduction for  compensation  recognized in connection
with the exercise of these stock options. The affirmative vote of the holders of
a majority of the shares  present in person or represented by proxy and entitled
to vote at the meeting  will be  required to approve the 1992 Plan,  as amended.
Abstentions  will be counted  toward the  tabulation  of votes cast on proposals
presented  to  stockholders  and will have the same  effect as  negative  votes.
Broker  non-votes  are  counted  towards a quorum,  but are not  counted for any
purpose in determining whether this matter has been approved.

             MANAGEMENT AND THE BOARD OF DIRECTORS RECOMMEND A VOTE
                             IN FAVOR OF PROPOSAL 2.


         The essential features of the 1992 Plan are outlined below:

General

         The 1992 Plan provides for the grant of both incentive and nonstatutory
stock options.  Incentive stock options granted under the 1992 Plan are intended
to qualify as "incentive stock options" within the meaning of Section 422 of the
Code.  Nonstatutory  stock options  granted under the 1992 Plan are intended not
qualify as incentive stock options under the Code. See "Federal Tax Information"
for a  discussion  of the tax  treatment  of incentive  and  nonstatutory  stock
options.


                                       5.
<PAGE>


Purpose

         The 1992 Plan was adopted to provide a means by which selected officers
and  employees of and  consultants  to the Company and its  affiliates  could be
given an opportunity  to purchase  stock in the Company,  to assist in retaining
the  services  of  employees  holding  key  positions,  to secure and retain the
services of persons capable of filling such positions and to provide  incentives
for such persons to exert maximum efforts for the success of the Company. All of
the Company's  employees and consultants are eligible to participate in the 1992
Plan.

Administration

         The 1992 Plan is administered by the Board.  The Board has the power to
construe and interpret the 1992 Plan and,  subject to the provisions of the 1992
Plan,  to determine  the persons to whom and the dates on which  options will be
granted,  the number of shares to be subject to each  option,  the time or times
during the term of each option  within which all or a portion of such option may
be exercised,  the exercise price, the type of consideration  and other terms of
the option.

         The 1992 Plan is  administered  by the Board unless and until the Board
delegates  administration to a committee  composed of two or more Board members,
all of the members of which  committee  may be  non-employee  directors (as such
term is defined in Rule 16b-3 promulgated  under the Securities  Exchange Act of
1934, as amended (the "Exchange Act"), and/or outside directors (as such term is
defined in the Treasury  regulations  promulgated  under  Section  162(m) of the
Code). If administration is delegated to a committee,  such committee will have,
in connection with the  administration of the 1992 Plan, the powers possessed by
the Board,  subject,  however,  to such  resolutions,  not inconsistent with the
provisions  of the 1992 Plan,  as may be adopted from time to time by the Board.
The Board or the committee may delegate to a committee of one or more members of
the Board the  authority to grant  options to eligible  persons who are not then
subject  to Section  16 of the  Exchange  Act and/or who are either (i) not then
employees  covered by Code Section  162(m) and are not expected to be covered by
Section 162(m) at the time of recognition of income  resulting from such option,
or (ii) not  persons  with  respect  to whom the  Company  wishes  to avoid  the
application of Section 162(m).  The Board may abolish such committee at any time
and  revest in the  Board the  administration  of the 1992  Plan.  The Board has
delegated  administration of the 1992 Plan to the Compensation  Committee of the
Board.  As used herein with respect to the 1992 Plan,  the "Board" refers to the
Compensation Committee as well as to the Board itself.

Eligibility

         Incentive  stock  options  may be  granted  under the 1992 Plan only to
selected key employees  (including  officers) of the Company and its affiliates.
Selected key  employees  (including  officers) and  consultants  are eligible to
receive  nonstatutory  stock options under the 1992 Plan.  Directors who are not
salaried  employees of or  consultants to the Company or to any affiliate of the
Company are not eligible to participate in the 1992 Plan.

         No option may be granted  under the 1992 Plan to any person who, at the
time of the  grant,  owns (or is deemed to own) stock  possessing  more than ten
percent (10%) of the total combined voting power of the Company or any affiliate
of the  Company,  unless the option  exercise  price is at least one hundred ten
percent  (110%) of the fair market  value of the stock  subject to the option on
the date of grant,  and the term of the option  does not exceed  five years from
the date of grant. For incentive stock options granted under the 1992 Plan after
1986, the aggregate fair market value,  determined at the time of grant,  of the
shares of Common Stock with respect to which such  options are  exercisable  for
the first time by an optionee  during any calendar year (under all such plans of
the Company and its affiliates) may not exceed $100,000.

Stock Subject to the 1992 Plan

         Subject to  stockholder  approval of this  Proposal 2, an  aggregate of
4,000,000  shares of Common Stock are  authorized  for  issuance  under the 1992
Plan.  If options  granted  under the 1992 Plan  expire or  otherwise  terminate
without being exercised, the Common Stock not purchased pursuant to such options
again becomes available for issuance under the 1992 Plan.


                                       6.
<PAGE>


Terms of Options

         The  following is a  description  of the  permissible  terms of options
under the 1992 Plan.  Individual option grants may be more restrictive as to any
or all of the permissible terms described below.

         Exercise Price;  Payment. The exercise price of incentive stock options
under  the 1992 Plan may not be less than the fair  market  value of the  Common
Stock subject to the option on the date of the option  grant,  and in some cases
(see  "Eligibility"  above), may not be less than one hundred ten percent (110%)
of such fair market value. The exercise price of nonstatutory  options under the
1992  Plan may not be less than  eighty-five  percent  (85%) of the fair  market
value of the Common Stock subject to the option on the date of the option grant.
At  February  27,  1998,  the closing  price of the  Company's  Common  Stock as
reported on the Nasdaq National Market System was $14.875.

         The exercise price of options  granted under the 1992 Plan must be paid
either:  (a) in cash at the time the option is exercised;  (b) at the discretion
of the Board,  by delivery of other Common Stock of the Company or pursuant to a
deferred payment  arrangement,  or (c) in any other form of legal  consideration
acceptable to the Board.

         Option  Exercise.  Options  granted  under  the 1992  Plan  may  become
exercisable ("vest") in cumulative increments as determined by the Board. Shares
covered by options  granted in the future  under the 1992 Plan may be subject to
different  vesting terms.  Options granted to date under the 1992 Plan typically
vest in cumulative  increments over a period of five years during the optionee's
employment or service as a consultant. The Board has the power to accelerate the
time during which an option may be exercised. In addition, options granted under
the 1992  Plan may  permit  exercise  prior to  vesting,  but in such  event the
optionee  may be  required  to  enter  into an  early  exercise  stock  purchase
agreement that allows the Company to repurchase shares not yet vested should the
optionee leave the employ of the Company before vesting.  To the extent provided
by the terms of an option,  an optionee may satisfy any federal,  state or local
tax  withholding  obligation  relating to the  exercise of such option by a cash
payment upon exercise,  by authorizing  the Company to withhold a portion of the
stock otherwise issuable to the optionee,  by delivering  already-owned stock of
the Company or by a combination of these means.

         Term.  The  maximum  term of options  under the 1992 Plan is ten years,
except that in certain cases (see "Eligibility") the maximum term is five years.
Options under the 1992 Plan terminate  three months after the optionee ceases to
be employed  by the  Company or any  affiliate  of the  Company,  unless (a) the
termination of employment is due to such person's permanent and total disability
(as defined in the Code),  in which case the option may,  but need not,  provide
that  it may be  exercised  at any  time  within  twelve  (12)  months  of  such
termination;  (b)  the  optionee  dies  while  employed  by the  Company  or any
affiliate  of the Company,  in which case the option may, but need not,  provide
that it may be exercised (to the extent the option was  exercisable  at the time
of the optionee's  death) within eighteen (18) months of the optionee's death by
the person or persons to whom the rights to such  option  pass by will or by the
laws of descent and  distribution;  or (c) the option by its terms  specifically
provides  otherwise.  Individual options by their terms may provide for exercise
within a longer  period  of time  following  termination  of  employment  or the
consulting relationship.  The option term may also be extended in the event that
exercise of the option within these periods is prohibited for specified reasons.

Adjustment Provisions

         If any change is made in the stock  subject to the 1992 Plan or subject
to any option  without the  receipt of  consideration  by the  Company  (through
merger, consolidation, reorganization, recapitalization,  reincorporation, stock
dividend,  dividend  in  property  other than  cash,  stock  split,  liquidating
dividend,  combination  of  shares,  exchange  of  shares,  change in  corporate
structure or other transaction not involving the receipt of consideration by the
Company),  the 1992 Plan will be  appropriately  adjusted in the  class(es)  and
maximum  number of  securities  subject to the 1992 Plan  pursuant to subsection
4(a) of the 1992 Plan and the maximum  number of securities  subject to award to
any person pursuant to subsection 5(c) of the 1992 Plan, and outstanding options
will be  appropriately  adjusted in the class(es)  and number of securities  and
price per share of stock subject to such outstanding  options.  Such adjustments
shall be made by the Board, the  determination of which shall be final,  binding
and conclusive.  (The  conversion of any  convertible  securities of the Company
shall not be treated as a transaction  "without receipt of consideration" by the
Company.)


                                       7.
<PAGE>


Effect of Certain Corporate Events

         The 1992 Plan provides that, in the event of a specified type of merger
or other corporate reorganization, to the extent permitted by law, any surviving
corporation  shall  assume  any  options  outstanding  under  the  1992  Plan or
substitute  similar  options  for those  outstanding  under such  plan,  or such
outstanding  options will  continue in full force and effect.  In the event that
any  surviving  corporation  refuses to assume or continue  options  outstanding
under the 1992 Plan, or to substitute  similar options,  then such options shall
be  terminated  if  not  exercised  prior  to  such  event.  In the  event  of a
dissolution  or  liquidation  of the  Company,  any  options  outstanding  shall
terminate if not exercised prior to such event.

Duration, Amendment and Termination.

         The Board may suspend or terminate  the 1992 Plan  without  stockholder
approval or ratification at any time.  Unless sooner  terminated,  the 1992 Plan
will terminate on March 11, 2006.

         The  Board  may also  amend  the 1992  Plan at any time or from time to
time.   However,   no  amendment  will  be  effective  unless  approved  by  the
stockholders of the Company within twelve months before or after its adoption by
the Board to the  extent  stockholder  approval  is  necessary  to  satisfy  the
requirements  of  Section  422 of the Code,  Rule  16b-3  promulgated  under the
Exchange Act, or any Nasdaq or other securities  exchange listing  requirements.
The Board may in its sole discretion submit any other amendment to the 1992 Plan
for stockholder approval.

Restrictions on Transfer

         Under the 1992 Plan, an incentive  stock option may not be  transferred
by  the  optionee  otherwise  than  by  will  or by  the  laws  of  descent  and
distribution.  During the lifetime of an optionee, an incentive stock option may
be exercised only by the optionee.  A nonstatutory  stock option is transferable
to the extent provided in the option  agreement.  If the option  agreement for a
nonstatutory  stock  option  does  not  provide  for  transferability,  then the
nonstatutory  stock option is not transferable  except by will or by the laws of
descent and distribution and is exercisable  during the lifetime of the optionee
only by the optionee.  In addition,  shares subject to repurchase by the Company
under an early exercise stock purchase  agreement may be subject to restrictions
on transfer which the Board deems appropriate.

Federal Income Tax Information

         Incentive  Stock Options.  Incentive  Stock options under the 1992 Plan
are  intended to be eligible  for the  favorable  federal  income tax  treatment
accorded "incentive stock options" under the Code.

         There generally are no federal income tax  consequences to the optionee
or the Company by reason of the grant or exercise of an incentive  stock option.
However,  the exercise of an incentive  stock option may increase the optionee's
alternative minimum tax liability, if any.

         If an optionee  holds stock acquired  through  exercise of an incentive
stock  option  for more  than two  years  from the date on which  the  option is
granted and more than one year from the date on which the shares are transferred
to the optionee upon  exercise of the option,  any gain or loss on a disposition
of such stock will be long-term or mid-term capital gain or loss. Generally,  if
the  optionee  disposes of the stock  before the  expiration  of either of these
holding periods (a "disqualifying disposition"), at the time of disposition, the
optionee  will realize  taxable  ordinary  income equal to the lesser of (a) the
excess  of the  stock's  fair  market  value  on the date of  exercise  over the
exercise price,  or (b) the optionee's  actual gain, if any, on the purchase and
sale.  The  optionee's  additional  gain,  or any loss  upon  the  disqualifying
disposition will be a capital gain or loss which will be long-term,  mid-term or
short-term depending on how long the optionee held the stock. Slightly different
rules may apply to optionees  who acquire  stock  subject to certain  repurchase
options or who are subject to Section 16(b) of the Exchange Act.

         To the extent the optionee  recognizes  ordinary  income by reason of a
disqualifying  disposition,  the Company will generally be entitled  (subject to
the  requirement  of  reasonableness  and the  satisfaction  of a tax  reporting
obligation) to a  corresponding  business  expense  deduction in the tax year in
which the a disqualifying disposition occurs.


                                       8.
<PAGE>


         Nonstatutory  Stock Options.  Nonstatutory  stock options granted under
the 1992 Plan generally have the following federal income tax consequences:

         There are no tax  consequences to the optionee or the Company by reason
of the grant of a  nonstatutory  stock option.  Upon exercise of a  nonstatutory
stock option, the optionee normally will recognize taxable ordinary income equal
to the excess of the stock's fair market value on the date of exercise  over the
option  exercise  price.  Generally,  with respect to employees,  the Company is
required to withhold from regular wages or supplemental  wage payments an amount
based  on  the  ordinary  income  recognized.  Subject  to  the  requirement  of
reasonableness and the satisfaction of any tax reporting obligation, the Company
will generally be entitled to a business expense  deduction equal to the taxable
ordinary income  realized by the optionee.  Upon  disposition of the stock,  the
optionee will recognize a capital gain or loss equal to the  difference  between
the selling  price and the sum of the amount paid for such stock plus any amount
recognized  as ordinary  income upon  exercise of the option.  Such gain or loss
will be  long-term,  mid-term or  short-term  depending on how long the optionee
held the stock.  Slightly  different  rules may apply to  optionees  who acquire
stock subject to certain  repurchase options or who are subject to Section 16(b)
of the Exchange Act.

         Potential Limitation on Company Deductions.  Section 162(m) of the Code
which denies a deduction to any publicly held corporation for compensation  paid
to certain employees in a taxable year to the extent that  compensation  exceeds
$1,000,000 for a covered employee. It is possible that compensation attributable
to stock options, when combined with all other types of compensation received by
a covered employee from the Company, may cause this limitation to be exceeded in
any particular year.

         Certain kinds of compensation,  including qualified  "performance-based
compensation,"  are  disregarded  for purposes of the deduction  limitation.  In
accordance with Treasury  regulations issued under Section 162(m),  compensation
attributable  to stock options will qualify as  performance-based  compensation,
provided that the option is granted by a compensation committee comprised solely
of "outside  directors" and either:  (i) the option plan contains a per-employee
limitation  on the number of shares for which  options  may be granted  during a
specified period,  the per-employee  limitation is approved by the stockholders,
and the  exercise  price of the option is no less than the fair market  value of
the stock on the date of grant;  or (ii) the option is granted (or  exercisable)
only  upon  the  achievement  (as  certified  in  writing  by  the  compensation
committee)  of an  objective  performance  goal  established  in  writing by the
compensation  committee while the outcome is  substantially  uncertain,  and the
option is approved by stockholders.


                                 PR0PROPOSAL 3

                APPROVAL OF THE 1998 EMPLOYEE STOCK PURCHASE PLAN


         In February  1998,  the Board adopted the Company's 1998 Employee Stock
Purchase Plan (the "Purchase  Plan").  The Purchase Plan authorizes the issuance
of  200,000  shares of Common  Stock  pursuant  to  purchase  rights  granted to
employees of the Company and is intended to be an "employee stock purchase plan"
as defined in Section 423 of the Code.

         The Purchase  Plan was adopted by the Board to provide a means by which
employees  of the Company and its  affiliates  will be given an  opportunity  to
purchase  stock in the  Company,  to assist in  retaining  the  services  of its
employees,  to secure and retain the  services of new  employees  and to provide
incentives  for such  persons to exert  maximum  efforts  for the success of the
Company.

         Stockholders  are  requested in this Proposal 3 to approve the Purchase
Plan. The affirmative vote of the holders of a majority of the shares present in
person or  represented  by proxy and  entitled  to vote on the  proposal  at the
meeting will be required to approve the  proposal.  Abstentions  will be counted
toward  the  tabulation  of votes  cast on the  proposal  and will have the same
effect as negative votes.  Broker non-votes are counted towards a quorum but are
not  counted  for any  purpose  in  determining  whether  this  matter  has been
approved.


                                       9.

<PAGE>

             MANAGEMENT AND THE BOARD OF DIRECTORS RECOMMEND A VOTE
                             IN FAVOR OF PROPOSAL 3.



The essential features of the Purchase Plan are outlined below.

Purpose

         The  purpose  of the  Purchase  Plan is (i) to provide a means by which
employees of the Company (and any parent or subsidiary of the Company designated
by the Board to participate in the Purchase Plan) may be given an opportunity to
purchase  Common Stock of the Company through  payroll  deductions,  and (ii) to
assist the Company in (a) securing the services of new employees,  (b) retaining
the  services of  existing  employees,  and (c)  providing  incentives  for such
persons to exert maximum  efforts for the success of the Company.  The rights to
purchase Common Stock granted under the Purchase Plan are intended to qualify as
options  issued under an "employee  stock purchase plan" as that term is defined
in Section 423(b) of the Code.

Administration

         The  Purchase  Plan is  administered  by the Board  which has the final
power to construe and interpret  the Purchase Plan and the rights  granted under
it. The Board has the power,  subject to the provisions of the Purchase Plan, to
determine  when and how rights to purchase  Common  Stock will be  granted,  the
provisions of each offering of such rights  (which need not be  identical),  and
whether  employees of any  affiliate  (defined in the Purchase  Plan to mean any
parent or subsidiary  of the Company)  shall be eligible to  participate  in the
Purchase  Plan.  The  Board  has the  power to  delegate  administration  of the
Purchase Plan to a committee of two or more Board members. The Board may abolish
any such committee at any time and revest in the Board the administration of the
Purchase  Plan.  As used herein with respect to the Purchase  Plan,  the "Board"
refers to such committee as well as to the Board itself.

Stock Subject to Purchase Plan

         Subject to  stockholder  approval of this  Proposal 3, an  aggregate of
200,000  shares of Common Stock is  authorized  for issuance  under the Purchase
Plan.  If rights  granted  under the Purchase  Plan  expire,  lapse or otherwise
terminate  without  being  exercised,  the shares of Common Stock not  purchased
under such rights again become available for issuance under the Purchase Plan.

Offerings

         The Purchase Plan is implemented by offerings of rights to all eligible
employees  from time to time by the Board.  Such  offerings have a duration of 6
months.  The initial offering is scheduled to commence on August 1, 1998, with a
purchase  date of January 31, 1999.  As of February  28, 1998,  no shares of the
Common Stock had been purchased under the Purchase Plan.

Eligibility

         Any person who is  customarily  employed at least 20 hours per week and
five months per  calendar  year by the Company (or by any  affiliate  designated
from  time to time by the  Board)  on the  first  day of an  offering  period is
eligible to participate in that offering under the Purchase Plan,  provided such
employee  has been in the  continuous  employ of the  Company for such period of
time  preceding  the first day of the offering  period as shall be determined by
the Board, which period must be in all cases less than two years. If, during the
course  of  an  offering,   an  employee  satisfies  the  foregoing  eligibility
requirements,  the Board may provide that such employee may  participate in that
offering.

         Notwithstanding the foregoing, no employee is eligible for the grant of
any  rights  under the  Purchase  Plan if,  immediately  after such  grant,  the
employee would own,  directly or indirectly,  stock possessing 5% or more of the
total  combined  voting power or value of all classes of stock of the Company or
of any affiliate (including any stock which such employee may purchase under all
outstanding rights and options),  nor will any employee be granted rights to buy
more than  $25,000  worth of stock  (determined  at the fair market value of the
shares at the time such rights are granted)  under all employee  stock  purchase
plans of the Company in any calendar year.


                                      10.
<PAGE>


Participation

         An eligible  employee  becomes a  participant  in the Purchase  Plan by
delivering  to the  Company,  prior to the time set  forth in the  offering,  an
agreement  authorizing payroll deductions of up to 10% (or such lower percentage
as the  Board  may  determine  for a  particular  offering)  of such  employee's
compensation during the offering.

Purchase Price

         The  purchase  price per share at which  shares are sold in an offering
under  the  Purchase  Plan  cannot be less than the lower of (i) 85% of the fair
market  value of a share of  Common  Stock  on the date of  commencement  of the
offering, or (ii) 85% of the fair market value of a share of Common Stock on the
date of purchase.

Payment of Purchase Price; Payroll Deductions

         The purchase price of the shares is  accumulated by payroll  deductions
over the offering period. A participant may increase,  reduce,  or commence such
payroll  deductions  after the beginning of any offering period only as provided
for in the offering.  All payroll deductions made for a participant are credited
to his or her account  under the Purchase  Plan and  deposited  with the general
funds of the Company.

Purchase of Stock

         By executing an  agreement to  participate,  an employee is entitled to
purchase shares under the Purchase Plan. In connection with offerings made under
the Purchase Plan,  the Board  specifies a maximum number of shares any employee
may be granted the right to purchase and the maximum  aggregate number of shares
which may be purchased  pursuant to such  offering by all  participants.  If the
aggregate  number of shares to be purchased  upon exercise of rights  granted in
the offering were to exceed the maximum aggregate number, the Board would make a
pro rata  allocation  of shares  available  in a uniform and  equitable  manner.
Unless  the  employee's  participation  is  discontinued,  his or her  right  to
purchase shares is exercised  automatically at the end of the offering period at
the applicable price. See "Withdrawal."

Withdrawal

         While each  participant  in the  Purchase  Plan is  required to sign an
agreement  authorizing payroll  deductions,  the participant may withdraw from a
given  offering by  delivering  to the Company a notice of  withdrawal  from the
Purchase  Plan,  which  will  terminate  his or  her  payroll  deductions.  Such
withdrawal  may be  elected  at any  time  prior  to the  end of the  applicable
offering, except as provided by the Board in the offering.

         Upon any withdrawal  from an offering by the employee,  at the election
of  such  employee  the  Company  will  distribute  to the  employee  his or her
accumulated payroll deductions without interest, less any accumulated deductions
previously applied to the purchase of stock on the employee's behalf during such
offering  and such  employee's  interest in the offering  will be  automatically
terminated.  An employee's  withdrawal from an offering will not have any effect
upon such  employee's  eligibility to participate in subsequent  offerings under
the Purchase Plan.

Termination of Employment

         Rights  granted  pursuant  to any  offering  under  the  Purchase  Plan
terminate immediately upon cessation of an employee's employment for any reason,
and the Company will  distribute  to the employee all of his or her  accumulated
payroll  deductions  (reduced to the extent,  if any, such  deductions have been
used to acquire stock for the terminated  employee) under the offering,  without
interest.

Restrictions on Transfer

         Rights granted under the Purchase Plan are not  transferable and may be
exercised only by the person to whom such rights are granted.


                                      11.
<PAGE>


Duration, Amendment and Termination

         The Board may  suspend,  terminate  or amend the  Purchase  Plan at any
time.

         The Board at any time,  and from time to time,  may amend the  Purchase
Plan.  However,  any  amendment  of the  Purchase  Plan must be  approved by the
stockholders  within 12 months of its  adoption  by the Board to the extent such
amendment requires stockholder approval in order for the Purchase Plan to obtain
employee  stock  purchase  plan  treatment  under  Section 423 of the Code or to
comply with the requirements of Rule 16b-3 promulgated under the Exchange Act or
any Nasdaq or any other securities exchange listing requirements.

         Rights  granted  before  amendment or  termination of the Purchase Plan
will not be altered or impaired by any amendment or  termination of the Purchase
Plan without consent of the person to whom such rights were granted.

Adjustment Provisions

         If there is any  change in the stock  subject to the  Purchase  Plan or
subject  to  any  rights  granted  under  the  Purchase  Plan  (through  merger,
consolidation,  reorganization,  recapitalization,  stock dividend, stock split,
change in  corporate  structure  or  otherwise),  the  Purchase  Plan and rights
outstanding  thereunder will be  appropriately  adjusted as to the class and the
maximum number of shares subject to such Purchase Plan and the class,  number of
shares and price per share of stock subject to such outstanding rights.

Effect of Certain Corporate Events

         In the event of a dissolution,  liquidation or specified type of merger
of the Company,  then, as determined by the Board in its sole discretion (i) any
surviving corporation may assume outstanding rights or substitute similar rights
for those  outstanding under the Purchase Plan, (ii) such rights may continue in
full force and effect or (iii) participants'  accumulated payroll deductions may
be used to purchase Common Stock immediately prior to the transaction  described
above and the participants' rights under the ongoing offering terminated.

Federal Income Tax Information

         Rights  granted  under the  Purchase  Plan are  intended to qualify for
favorable  federal income tax treatment  associated with rights granted under an
employee stock purchase plan which qualifies under the provisions of Section 423
of the Code.

         A  participant  will be taxed on amounts  withheld  for the purchase of
shares as if such  amounts  were  actually  received.  No other  income  will be
taxable to a  participant  until  disposition  of the shares  acquired,  and the
method of taxation will depend upon the holding period of the purchased shares.

         If the stock  purchased in an offering is sold (or  otherwise  disposed
of) more than two years after the  beginning  of the  offering and more than one
year after the stock is transferred to the  participant,  then the lesser of (i)
the excess of the fair market value of the stock at the time of such disposition
over the purchase price or (ii) the excess of the fair market value of the stock
as of the beginning of the offering over the purchase  price  (determined  as of
the beginning of the offering) will be treated as ordinary  income.  Any further
gain or any loss will be taxed as capital gain or loss.

         If the stock is sold or disposed of before the  expiration of either of
the holding periods described above, then the excess of the fair market value of
the stock on the  purchase  date over the  purchase  price  will be  treated  as
ordinary  income at the time of such  disposition,  and the Company  may, in the
future,  be required to withhold  income taxes relating to such ordinary  income
from other  payments  made to the  participant.  The balance of any gain will be
treated as capital  gain.  Even if the stock is later  disposed of for less than
its fair market value on the purchase date,  the same amount of ordinary  income
is attributed to the participant,  and a capital loss is recognized equal to the
difference  between the sales  price and the fair  market  value of the stock on
such  purchase  date.  Any capital gain or loss will be  long-term,  mid-term or
short-term depending on how long the stock has been held.

         There are no federal income tax  consequences  to the Company by reason
of the grant or exercise of rights (i.e.,  purchase of stock) under the Purchase
Plan.  The Company is entitled to a deduction to the extent amounts are 


                                      12.
<PAGE>

taxed as ordinary income to a participant by reason of a disposition  before the
expiration of the holding periods described above (subject to the requirement of
reasonableness and a tax reporting obligation).


                                   PROPOSAL 4

                RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS


         The Board of Directors has selected  Ernst & Young LLP as the Company's
independent  auditors  for the fiscal  year  ending  December  31,  1998 and has
further  directed that management  submit the selection of independent  auditors
for  ratification by the  stockholders at the Annual Meeting.  Ernst & Young LLP
has audited the  Company's  financial  statements  since its  inception in 1992.
Representatives  of Ernst & Young LLP are  expected  to be present at the Annual
Meeting, will have an opportunity to make a statement if they so desire and will
be available to respond to appropriate questions.

         Stockholder  ratification  of the selection of Ernst & Young LLP as the
Company's  independent  auditors  is not  required by the  Company's  By-laws or
otherwise.  However,  the Board is submitting the selection of Ernst & Young LLP
to the stockholders for ratification as a matter of good corporate practice.  If
the stockholders fail to ratify the selection, the Audit Committee and the Board
will  reconsider  whether or not to retain that firm.  Even if the  selection is
ratified,  the Audit Committee and the Board in their  discretion may direct the
appointment  of  different  independent  auditors at any time during the year if
they  determine that such a change would be in the best interests of the Company
and its stockholders.

         The affirmative vote of the holders of a majority of the shares present
in person or  represented  by proxy and  entitled to vote at the Annual  Meeting
will be required to ratify the selection of Ernst & Young LLP.

             MANAGEMENT AND THE BOARD OF DIRECTORS RECOMMEND A VOTE
                             IN FAVOR OF PROPOSAL 4.


                                      13.
<PAGE>


           STOCK OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT
<TABLE>
         The following table sets forth certain information regarding beneficial
ownership of the Common Stock (on an as-if  converted  basis) as of February 28,
1998, by (i) each  stockholder  who is known by the Company to own  beneficially
more than 5% of the Common Stock (on an as-if converted basis);  (ii) each Named
Executive Officer of the Company listed on the Summary Compensation Table below;
(iii)  each  director  of the  Company;  and (iv) all  directors  and  executive
officers  of the  Company as a group.  All Series D  preferred  stock is held by
Hoechst  Marion  Roussel as  reflected in the Common Stock table and as noted in
footnote (10).
<CAPTION>
                                                                            Series B                 Series C
Name and Address                             Common Stock(1)           Preferred Stock(1)       Preferred Stock(1)
of Beneficial Owners                      Number     Percent(2)        Number   Percent(2)     Number     Percent(2)
- --------------------                      ------     ----------        ------   ----------     ------     ----------
<S>                                       <C>          <C>             <C>         <C>         <C>           <C>
Entities affiliated with
     U.S. Venture Partners IV, L.P.(3)    730,000      10.9%           50,000      15.0%       23,000        18.7%
     2180 Sand Hill Road, Suite 300
     Menlo Park, CA  94025

Entities affiliated with the
     Sprout Group(4)                      729,980      10.9%           49,999      15.0%       22,999        18.7%
     3000 Sand Hill Road
     Building 4, Suite 270
     Menlo Park, CA  94025

Cannon Street Fund Ltd.                   565,000       8.7%           40,000      12.0%       16,500        13.4%
     c/o Meridian Venture Group
     R.R. Box 272
     Charlottesville, VA  22314

Biotechnology Investments Limited         545,000       8.4%           40,000      12.0%       14,500        11.8%
     c/o Old Court Limited
     P.O. Box 58
     St. Julian's Court
     St. Peter Port
     Guernsey, Channel Islands

Entities affiliated with
     INVESCO Trust Company(5)             522,500       8.8%               --        N/A           --          N/A
     7800 East Union Avenue
     Denver, CO  80237

Entities affiliated with
     WPG-Farber, Present Fund LLP(6)      505,000       8.4%               --        N/A           --          N/A
     c/o Weiss, Peck & Greer, L.L.C.
     One New York Plaza
     New York, NY  10004

Lombard Odier & Cie(7)                    490,000       8.2%               --        N/A           --          N/A
     11 Rue de la Corraterie
     1204 Geneva, Switzerland

Entities affiliated with
     Mehta and Isaly(8)                   450,000       7.6%               --        N/A           --          N/A
     41 Madison Avenue
     New York, NY  10010


                                                           14.
<PAGE>

                                                                            Series B                 Series C
Name and Address                             Common Stock(1)           Preferred Stock(1)       Preferred Stock(1)
of Beneficial Owners                      Number     Percent(2)        Number   Percent(2)     Number     Percent(2)
- --------------------                      ------     ----------        ------   ----------     ------     ----------

Singapore Bio-Innovations Pte, Ltd.       420,000       6.6%           42,000      12.6%           --          N/A
     250 North Bridge Road
     24-00 Raffles City Tower
     Singapore  0617

Entities affiliated with
     Partech International(9)             415,000       6.7%           15,000       4.5%       15,000        12.2%
     101 California Ave., Suite 3150
     San Francisco, CA  94111

Hoechst Marion Roussel(10)                400,000       6.3%               --        N/A           --          N/A
     10236 Marion Park Drive
     Kansas City, MO  64137-1405

Entities affiliated with
     The Tisch Family(11)                 400,000       6.7%               --        N/A           --          N/A
     667 Madison Avenue
     New York, NY  10021

Asset Management Associates               360,000       5.7%           36,000      10.8%           --          N/A
  1989 L.P.(12)
     2275 East Bayshore Rd., #150
     Palo Alto, CA  94303

Chiron Corporation                        300,000       5.1%               --        N/A           --          N/A
     4360 Horton Street
     Emeryville, CA  94608

Sam Eletr, Ph.D.(13)                      463,759       7.5%               --        N/A           --          N/A
     Lynx Therapeutics, Inc.
     3832 Bay Center Place
     Hayward, CA  94545

William K. Bowes, Jr.(14)                 747,721      11.2%           50,000      15.0%       23,000        18.7%
     U.S. Venture Partners IV, L.P.
     2180 Sand Hill Road, Suite 300
     Menlo Park, CA  94025

Sydney Brenner, M.D., D. Phil.(15)        287,375       4.3%               --        N/A           --          N/A

Timothy G. Geiser(16)                     160,327       2.6%               --        N/A           --          N/A

James C. Kitch(17)                         17,818         **              700         **          300           **

Kathleen D. La Porte(4)                   729,980      10.9%           49,999      15.0%       22,999        18.7%
     Sprout Group
     3000 Sand Hill Road
     Building 4, Suite 270
     Menlo Park, CA  94025

Stephen C. Macevicz, Ph.D.(18)            106,151       1.8%               --        N/A           --          N/A

Karoly Nikolich, Ph.D.(19)                100,000       1.7%               --        N/A           --          N/A


                                                          15.
<PAGE>


                                                                            Series B                 Series C
Name and Address                             Common Stock(1)           Preferred Stock(1)       Preferred Stock(1)
of Beneficial Owners                      Number     Percent(2)        Number   Percent(2)     Number     Percent(2)
- --------------------                      ------     ----------        ------   ----------     ------     ----------

Craig C. Taylor(20)                       371,497       5.9%           36,000      10.8%        1,000           **
     Asset Management Associates
       1989 L.P.
     2275 East Bayshore Rd., #150
     Palo Alto, CA  94303

Gerald Zon, Ph.D.(21)                     160,806       2.6%               --        N/A           --          N/A

All directors and officers              3,195,434      38.1%          136,699      41.1%       47,299        38.4%
     as a group (11 persons)(22)
<FN>
**Less than one percent.

 (1)     Except as otherwise noted, and subject to community property laws where
         applicable,  each  person or entity  named in the table has sole voting
         and investment  power with respect to all shares shown as  beneficially
         owned by him, her or it. Beneficial  ownership of Common Stock reflects
         beneficial ownership of Series B preferred stock and Series C preferred
         stock as set forth in the  table,  and  Series D  preferred  stock with
         respect to Hoechst Marion Roussel, as set forth in footnote (10).

 (2)     Percentage  of  beneficial  ownership is based on  5,940,269  shares of
         Common Stock, 332,288 shares of the Company's Series B preferred stock,
         123,299  shares of the  Company's  Series C preferred  stock and 40,000
         shares of the  Company's  Series D preferred  stock  outstanding  as of
         February 28,  1998,  except as otherwise  noted in the  footnotes.  The
         Series B, Series C and Series D preferred  stock  converted into Common
         Stock on a ten-for-one basis on March 31, 1998. Beneficial ownership is
         determined in accordance  with the rules of the Securities and Exchange
         Commission  and  generally  includes  voting or  investment  power with
         respect  to  securities.  Shares of Common  Stock  subject  to  options
         currently  exercisable  or  exercisable  within 60 days of February 28,
         1998, are deemed outstanding for computing the percentage of the person
         holding such option but are not deemed  outstanding  for  computing the
         percentage of any other person.

 (3)     Includes 50,000 shares of Series B preferred stock and 23,000 shares of
         Series C preferred stock held by entities  affiliated with U.S. Venture
         Partners  IV,  L.P.  ("U.S.V.P.  IV").  Mr.  Bowes,  a director  of the
         Company,  is a general  partner of  Presidio  Management  Group IV, the
         general partner of U.S.V.P.  IV. Mr. Bowes shares the power to vote and
         control the disposition of shares held by U.S.V.P. IV and therefore may
         be  deemed  to be the  beneficial  owner  of  such  shares.  Mr.  Bowes
         disclaims beneficial ownership of such shares,  except to the extent of
         his pro-rata interest therein.

 (4)     Includes 49,999 shares of Series B preferred stock and 22,999 shares of
         Series C preferred stock held by entities affiliated with Sprout Group.
         Ms. La Porte,  a director of the Company,  is a general  partner of the
         Sprout  Group,  an entity  affiliated  with Sprout  Capital VI,  Sprout
         Capital VII and DLJ Capital.  Ms. La Porte shares the power to vote and
         control the  disposition  of shares held by Sprout  Capital VI,  Sprout
         Capital  VII and DLJ  Capital  and  therefore  may be  deemed to be the
         beneficial  owner of such  shares.  Ms. La Porte  disclaims  beneficial
         ownership of such shares, except to the extent of her pro-rata interest
         therein.

(5)      Includes  522,500  shares of Common  Stock held by entities  affiliated
         with INVESCO Trust Company.

(6)      Includes  500,000  shares of Common  Stock held by entities  affiliated
         with WPG-Farber-Weber Fund.

(7)      Includes  490,000 shares of Common Stock held by Lombard Odier & Cie as
         custodian.  Lombard Odier & Cie disclaims  beneficial ownership of such
         shares.

(8)      Includes  450,000  shares of Common  Stock held by entities  affiliated
         with Mehta and Isaly.

(9)      Includes  115,000  shares of Common Stock,  150,000  shares of Series B
         preferred  stock and 150,000 shares of Series C preferred stock held by
         entities affiliated with Partech International.


                                      16.
<PAGE>


(10)     Consists  solely of 40,000  shares of Series D preferred  stock,  which
         constitutes 100% of the shares of Series D preferred stock outstanding.

(11)     Includes  400,000  shares of Common  Stock held by entities  affiliated
         with the Tisch Family Interests.

(12)     Includes  36,000  shares  of  Series B  preferred  stock  held by Asset
         Management  Associates  1989 L.P.  ("Asset 1989 L.P.").  Mr. Taylor,  a
         director of the Company, is a general partner of AMC Partners 89, which
         is the general  partner of Asset 1989 L.P. Mr.  Taylor shares the power
         to vote and control the  disposition  of shares held by Asset 1989 L.P.
         and therefore may be deemed to be the beneficial  owner of such shares.
         Mr. Taylor disclaims beneficial ownership of such shares, except to the
         extent of his pro-rata interest therein.

(13)     Includes  217,500 shares of Common Stock issuable upon exercise of Lynx
         stock options held by Dr. Eletr that are exercisable within 60 days.

(14)     See Note 3 above.  Common Stock amount also includes 17,721 shares held
         by Mr. Bowes.

(15)     Includes  27,375 shares of Common Stock  issuable upon exercise of Lynx
         stock  options held by Sydney  Brenner that are  exercisable  within 60
         days.

(16)     Includes  123,500 shares of Common Stock issuable upon exercise of Lynx
         stock options held by Dr. Geiser that are  exercisable  within 60 days.
         Also  includes 4 shares of Common Stock held of record by Dr.  Geiser's
         wife, as to which shares Dr. Geiser disclaims beneficial ownership.

(17)     Includes  700  shares of  Series B  preferred  stock and 300  shares of
         Series  C  preferred  stock  held by GC&H  Investments,  an  investment
         partnership of which Mr. Kitch, a director of the Company, is a general
         partner. Also includes 1,985 shares of Common Stock and 5,833 shares of
         Common Stock  issuable  upon the exercise of Lynx stock options held by
         Mr. Kitch on behalf of GC&H Investments.  Mr. Kitch shares the power to
         vote and control the  disposition  of such shares and  therefore may be
         deemed to be the beneficial  owner of such shares.  Mr. Kitch disclaims
         beneficial  ownership  of such  shares,  except  to the  extent  of his
         pro-rata interest therein.

(18)     Includes  54,000 shares of Common Stock  issuable upon exercise of Lynx
         stock options held by Dr. Macevicz that are exercisable within 60 days.

(19)     Includes  40,000 shares of Common Stock  issuable upon exercise of Lynx
         stock options held by Dr. Nikolich that are exercisable within 60 days.

(20)     See Note 12 above.  Includes  1,497  shares  of Common  Stock and 1,000
         shares of Series C preferred stock held by Mr. Taylor.

(21)     Includes  130,750 shares of Common Stock issuable upon exercise of Lynx
         stock options held by Dr. Zon that are exercisable within 60 days. Also
         includes  105 shares of Common  Stock held of record by Dr.  Zon's wife
         and 64 shares of Common Stock  issuable  upon  exercise of Perkin Elmer
         Options held by Dr.  Zon's wife that are fully vested and  exercisable,
         as to which shares Dr. Zon disclaims beneficial ownership.

(22)     Common Stock amount includes  1,839,980 shares of Series B and Series C
         preferred stock (Common Stock  equivalent) held by entities  affiliated
         with certain directors and 599,022 shares of Common Stock issuable upon
         exercise of the Company's  stock options and Perkin Elmer stock options
         held by directors and officers that are exercisable within 60 days. See
         Notes 12 through 20 above.
</FN>
</TABLE>


Compliance With The Reporting Requirements Of Section 16(a)

         Section 16(a) of the Exchange Act requires the Company's  directors and
executive  officers,  and  persons  who own  more  than ten  percent  (10%) of a
registered  class  of the  Company's  equity  securities,  to file  with the SEC
initial reports of ownership and reports of changes in ownership of Common Stock
and other equity securities of the Company. Officers, directors and greater than
ten percent  (10%)  stockholders  are required by SEC  regulation to furnish the
Company with copies of all Section 16(a) forms they file.


                                      17.
<PAGE>


         To the Company's knowledge,  based solely on a review of copies of such
reports  furnished to the Company,  during the calendar year ended  December 31,
1997,  all  Section  16(a)  filing  requirements  applicable  to  its  officers,
directors  and greater than ten percent  (10%)  beneficial  owners were complied
with.

Directors

         Directors are not compensated by the Company for service as directors.


                             EXECUTIVE COMPENSATION

Executive Officers

         The  executive  officers of the Company and certain  information  about
them as of December 31, 1997 are listed below:

    Name                          Age     Company Positions
    ----                          ---     -----------------
    Sam Eletr, Ph.D.              58      Chief Executive Officer and
                                            Chairman of the Board
    Edward C. Albini              40      Chief Financial Officer and Secretary
    Timothy G. Geiser, Ph.D.      55      Vice President, Manufacturing
    Stephen C. Macevicz, Ph.D.    48      Vice President, Intellectual Property
    Karoly Nikolich, Ph.D.        49      Vice President, Research
    Gerald Zon, Ph.D.             52      Vice President, Medicinal Chemistry

         Sam Eletr,  Ph.D.,  has served as  Chairman of the Board of the Company
since February 1992 and resumed the position of Chief  Executive  Officer of the
Company in November 1996, a position he held from February 1992 through  January
1996.  In  1981,  Dr.  Eletr  founded  Applied   Biosystems,   Inc.  ("ABI"),  a
manufacturer  of  instruments  and  consumables  for life  science  research and
related applications, now a wholly-owned subsidiary of Perkin Elmer Corporation,
and  served as  Chairman  of the Board of  Directors  and in  various  executive
positions  at ABI from its  inception  until  March 1987.  Dr.  Eletr acted as a
consultant  to ABI from  September  1990 until July 1992,  during  which time he
undertook to assume the leadership of the Company.

         Edward C. Albini,  has served as Chief Financial Officer of the Company
since April 1997. He was elected Secretary of the Company in February 1998. From
January 1983 to April 1997,  Mr. Albini served in various  financial  management
positions with Genentech, Inc., a biotechnology company ("Genentech").  His most
recent role at Genentech was as the Director of Financial Planning and Analysis.
Mr. Albini holds a BS degree in Accounting  from Santa Clara  University  and an
MBA  degree  from  Walter  A. Haas  School  of  Business  at the  University  of
California at Berkeley. Mr. Albini is also a certified public accountant.

         Timothy G. Geiser,  Ph.D., has served as Vice President,  Manufacturing
of Lynx since July 1992.  Prior to that time,  he was a Senior  Scientist of ABI
from  May 1981 to July  1992,  where  he  directed  DNA  chemistry  and  peptide
chemistry R&D  activities and later joined with Dr. Zon in 1987 to co-direct the
establishment  of the DNA  Therapeutics  Group which led to the formation of the
Company. He received his Ph.D. in Organic Chemistry from Cornell University.

         Stephen C.  Macevicz,  Ph.D.,  joined the Company in September  1995 as
Vice President,  Intellectual  Property. He was Senior Patent Attorney and chief
patent counsel of ABI from 1992 to August 1995 and, prior to that,  from 1986 to
1992,  Patent  Counsel of DNAX  Research  Institute  of  Molecular  and Cellular
Biology, a research subsidiary of Schering-Plough  Corporation.  He received his
law degree from the University of California,  Berkeley (Boalt Hall) in 1984 and
his Ph.D. in Biophysics from the University of California, Berkeley in 1979.

         Karoly Nikolich,  Ph.D., has served as Vice President,  Research of the
Company since  November 1996 and was Vice  President,  Biological  Research from
October 1995 to November 1996. Prior to that time, he was a Senior Scientist and
Head of the Neuroscience  Research Program at Genentech from 1989 to 1995, and a
scientist from 1985 to 1989. Dr. Nikolich  established the neuroscience  program
at Genentech and is a widely  published  and


                                      18.
<PAGE>


recognized expert in neurotropic factor research.  After receiving his doctorate
from Eotvos  University  of  Budapest,  he was a  postdoctoral  fellow at Tulane
University and prior to joining  Genentech,  a visiting scientist at the Hormone
Research Laboratory, University of California, San Francisco.

         Gerald Zon, Ph.D.,  has served as Vice President,  Medicinal  Chemistry
and Head of Quality  Control and Regulatory  Affairs of Lynx since January 1993.
Dr.  Zon  joined  Lynx in July  1992.  Prior to that  time,  he served as Senior
Scientist at ABI from November 1986 to July 1992, and directed the Food and Drug
Administration's Pharmacology Laboratory from 1981 to 1986. Dr. Zon received his
Ph.D.  in  Organic  Chemistry  from  Princeton  University,  and  has  over  200
publications in the areas of organic, medicinal and oligonucleotide chemistry.

Compensation Tables

         Summary  Compensation  Table.  The following table sets forth,  for the
years ended December 31, 1997, 1996 and 1995, the  compensation  awarded or paid
to or earned by the Company's  Chief  Executive  Officer and its other four most
highly compensated executive officers at December 31, 1997 (the "Named Executive
Officers").
<TABLE>

                                           Summary Compensation Table
<CAPTION>
                                                                               Long Term
                                                               Annual         Compensation       All Other
Name and Principal Position                        Year       Salary(1)        Options(#)     Compensation(2)
- ---------------------------                        ----       ---------        ----------     ---------------
<S>                                                <C>        <C>                <C>           <C>
Sam Eletr, Ph.D                                    1997       $196,131              --         $   --
   Chief Executive Officer and                     1996        176,121            32,500           --
   Chairman of the Board                           1995        170,484           105,000           --

Timothy G. Geiser, Ph.D                            1997        156,634(3)           --              750
   Vice President, Manufacturing                   1996        153,818              --              750
                                                   1995        142,674            60,000            750

Stephen C. Macevicz, Ph.D                          1997        155,886              --              750
   Vice President, Intellectual Property 1996                  144,505              --              750
                                                   1995         53,632(4)        106,000           --

Karoly Nikolich, Ph.D                              1997        155,889              --              750
   Vice President, Research                        1996        150,210            30,000            750
                                                   1995         37,085(5)         70,000           --

Gerald Zon, Ph.D                                   1997        156,610(6)           --              750
   Vice President, Medicinal Chemistry             1996        154,168              --              750
                                                   1995        143,130            60,000            750
<FN>
(1)      Includes amounts earned but deferred at the election of the Named Executive  Officer pursuant to
         the Company's 401(k) Plan.
(2)      Contributions made by the Company to the Company's 401(k) Plan on behalf of such  employee.  
(3)      Dr.  Geiser  resigned  from the  Company in January  1998,  in  connection  with the sale of the
         phosphorothioate antisense assets to Inex Pharmaceuticals Corporation.
(4)      Dr. Macevicz  joined the Company in September 1995. The 1995 annual salary  represents a partial
         year.
(5)      Dr.  Nikolich  joined the Company in October 1995.  The 1995 annual salary  represents a partial
         year.
(6)      Dr.  Zon  resigned  from  the  Company  in  January  1998,  in  connection  with the sale of the
         phosphorothioate antisense assets to Inex Pharmaceuticals Corporation.
</FN>
</TABLE>

         Except as disclosed  above, no compensation  characterized as long-term
compensation,  including  restricted  stock awards  issued at a price below fair
market  value or  long-term  incentive  plan  payouts,  were paid by the Company
during the year ended December 31, 1997 to any of the Named Executive Officers.


                                       19.
<PAGE>


Stock Option Information

         There  were no grants of stock  options  to any of the Named  Executive
Officers in the Summary  Compensation  Table during the year ended  December 31,
1997.

         The  following  table sets forth  certain  information  concerning  the
number of options exercised by the Named Officers during the year ended December
31, 1997, and the number of shares covered by both exercisable and unexercisable
stock  options  held  by the  Named  Officers.  Also  reported  are  values  for
"in-the-money" options that represent the positive spread between the respective
exercise  prices  of  outstanding  options  and the  fair  market  value  of the
Company's Common Stock as of December 31, 1997 ($16.25 per share).
<TABLE>
                 Aggregated Option Exercises in the Year Ended December 31, 1997 and Option Values

<CAPTION>
                                                              Number of                 Value of Unexercised
                                                          Unexercised Options         In-the-Money Options at
                        Shares                              at Year-End                     Year-End (1)
                      Acquired on       Value        ----------------------------     ----------------------------
       Name            Exercise      Realized(1)     Exercisable   Unexercisable     Exercisable    Unexercisable
       ----            --------      -----------     -----------   -------------     -----------    -------------
<S>                      <C>         <C>               <C>             <C>           <C>              <C>
Sam Eletr                --          $  --             185,000         32,500        $2,621,250       $478,075
Timothy G. Geiser        --             --             123,500             --         1,771,025             --
Stephen C. Macevicz      --             --              54,000             --           856,650             --
Karoly Nikolich          --             --              40,000             --           495,000             --
Gerald Zon               --             --             130,750             --         1,883,613             --
<FN>
(1)      Based  on the  fair  market  value  of the  Company's  Common  Stock at
         December 31, 1997  ($16.25),  minus the  exercise  price of the option,
         multiplied by the number of shares underlying the options.
</FN>
</TABLE>


                      REPORT OF THE COMPENSATION COMMITTEE1

General

         The Company became a public  reporting  company in December l993,  when
the Company  registered its Common Stock and Series A preferred  stock under the
Exchange  Act, and the  Compensation  Committee  of the Board of  Directors  was
established  in March l994.  Accordingly,  the  Compensation  Committee made the
primary  compensation  determinations for the Company's officers during the year
ended  December  31,  1997,   including  the  establishment  of  base  salaries,
consideration  of bonuses and stock option  grants.  During 1997, the members of
the  Compensation  Committee  included  Kathleen La Porte and Craig Taylor.  The
Compensation   Committee  has  provided  the  following   with  respect  to  the
compensation of executive officers during the year ended December 31, 1997:

Compensation Philosophy

         The  Company  and  its   Compensation   Committee   believe   that  the
compensation of all employees,  including executive officers, must be sufficient
to attract and retain highly qualified personnel and that the Company must align
compensation with short-term and long-term  business  strategies and performance
goals. The current  compensation  philosophy is to emphasize  stockholder  value
linked with  incentives such as stock options over salary  increases.  The basic
elements of executive officer compensation are as follows:

         Salary. To insure that its compensation  practices remain  competitive,
the Company  compares its  compensation of executives with that of executives of
other  companies  of similar  industry,  size and  geographic  location.  Salary
increases  are  generally  granted  on an  annual  basis  and are  based on both
individual  performance and the standard  percentage of salary increases granted
to other employees.

- -------------------------------
1 The  Material  in this  report is not  "soliciting  material",  is not  deemed
"filed" with the SEC, and is not to be incorporated by reference into any filing
of the Company under the 1933 Act or 1934 Act,  whether made before or after the
date hereof and irrespective of any general incorporation  language contained in
such filing.

                                      20.
<PAGE>


         Bonuses.  During  1997,  the  Compensation  Committee  did not consider
bonuses  when  establishing  executive  compensation,  focusing  instead on base
salary and long-term incentives as the primary compensation vehicles appropriate
to the  early  stages  of the  Company's  development.  As part  of its  general
compensation   philosophy,   however,   the  Company   believes  that  executive
performance  may be maximized  via a system of annual  incentive  awards and the
Company may consider such awards in the future.

         Long-term  Incentives.  The  Company  believes  that  equity  ownership
provides significant  motivation to executive officers to maximize value for the
Company's  stockholders.  The  Compensation  Committee grants stock to executive
officers and other key  employees  based on a variety of factors,  including the
financial  performance  of the Company and  assessment of personal  performance.
Through stock option grants, executives receive significant equity incentives to
build long-term  stockholder  value. The exercise price of options  generally is
100% of the fair market  value as quoted on The Nasdaq  Stock Market on the date
of grant.  Employees  receive  value from these  grants only if the Common Stock
appreciates in the long term.

         Employment  and  Severance  Agreements.   The  Company  does  not  have
employment or severance agreements with any of its officers or employees.

Chief Executive Officer Compensation

         Dr.  Eletr's  compensation  was  established  in  accordance  with  the
criteria  described above and was determined by the Board primarily on the basis
of the salary received by Dr. Eletr in 1996 and pursuant to discussions  between
the Board and Dr. Eletr,  with  particular  consideration  given to Dr.  Eletr's
equity  ownership  position in the Company.  In establishing  compensation,  the
Board was mindful of the near  complete  dependence on Dr. Eletr for the success
and  direction  of  the  Company  given  its  early  stage  of  operation  as an
independent entity. Because of his ownership position in the Company, the salary
established  by the  Board may not  reflect a salary  that  would  otherwise  be
required  to  competitively  compensate  and  retain  Dr.  Eletr  and may not be
indicative of future compensation.

Certain Tax Considerations

         Section  162(m) of the Code  limits  the  Company  to a  deduction  for
federal income tax purposes of not more than $1 million of compensation  paid to
certain executive officers in a taxable year.  Compensation above $1 million may
be deducted if it is "performance-based  compensation" within the meaning of the
Code. The Board has not yet established a policy for determining  which forms of
incentive  compensation  awarded to  executive  officers  shall be  designed  to
qualify as performance based compensation.

         From the members of the Compensation Committee:

                  Kathleen La Porte
                  Craig Taylor

Performance Measurement Comparison

         The Common Stock was subject to certain restrictions on transfer as set
forth in the  Company's  By-laws,  which  restrictions  expired on September 30,
1994. The Company listed its Common Stock on The Nasdaq Stock Market on December
30, 1997. The Company has not included a Performance  Measurement  Graph in this
proxy  statement  because  such graph with one day of trading in  calendar  year
1997, will not provide meaningful information to the Company's stockholders.

Compensation Committee Interlocks and Insider Participation

         The Company's  Compensation  Committee was  established  in March 1994.
There  were  no  officers  or  employees  of the  Company  who  participated  in
deliberations  of the  Company's  Compensation  Committee  concerning  executive
officer compensation during the year ended December 31, 1997.


                                      21.
<PAGE>


Certain Relationships and Related Transactions

         In 1992,  Applied  Biosystems,  a  division  of Perkin  Elmer  ("ABI"),
distributed  all but an aggregate of 299,800  shares of the Lynx Common Stock it
held  to  its  shareholders  (the  "Distribution").   In  connection  with  this
transaction, Lynx granted ABI an option to purchase up to 215,900 shares of Lynx
Common  Stock at $0.10 per share  which,  prior to October  1996,  could only be
exercised by ABI in connection with the distribution by ABI of Lynx stock to its
option holders upon the exercise of ABI stock options outstanding as of the date
of the  Distribution.  In September  1997,  the option expired and the remaining
shares were canceled.

         In  October  1995,  the  Company  entered  into  a  full-recourse  loan
agreement with Karoly Nikolich, Ph.D., Vice President-Research of the Company. A
note receivable of $210,000 was issued under a stock purchase  agreement for the
purchase of 60,000  shares of Common Stock  whereby all the shares  issued under
the agreement are pledged as collateral. The outstanding principal amount is due
and payable in full in October  2000,  subject to an  obligation to prepay under
specified circumstances.  Interest is payable upon the expiration or termination
of the note and accrues at the rate of 6.38% per annum.

         In April 1997, the Company entered into a full-recourse  loan agreement
with Edward C. Albini,  Chief Financial Officer and Secretary of the Company.  A
note receivable of $250,000 was issued under a stock purchase  agreement for the
purchase of 50,000  shares of Common Stock  whereby all the shares  issued under
the agreement are pledged as collateral. The outstanding principal amount is due
and  payable in full in April 2002,  subject to an  obligation  to prepay  under
specified circumstances.  Interest is payable upon the expiration or termination
of the note and accrues at the rate of 6.49% per annum.

         For legal services rendered during the calendar year ended December 31,
1997,  the Company  paid  approximately  $228,449  to Cooley  Godward  LLP,  the
Company's counsel, of which Mr. Kitch, a director of the Company, is a partner.

                                  OTHER MATTERS

         The Board of Directors knows of no other matters that will be presented
for  consideration  at the Annual  Meeting.  If any other  matters are  properly
brought  before the meeting,  it is the  intention  of the persons  named in the
accompanying  proxy  to vote on such  matters  in  accordance  with  their  best
judgment.

                                            By Order of the Board of Directors





                                                     Edward C. Albini
                                    Secretary


April 13, 1998


         A copy of the Company's  Annual Report to the  Securities  and Exchange
Commission  on Form 10-K for the period ended  December  31, 1997,  is available
without charge upon written request to: Investor  Relations,  Lynx Therapeutics,
Inc., 3832 Bay Center Place, Hayward, California 94545.


                                      22.
<PAGE>
                             LYNX THERAPEUTICS, INC.
                             1992 STOCK OPTION PLAN

                              Adopted July 1, 1992
                            Amended February 26, 1998
                    Approved by the Stockholders ____________


1.       PURPOSES.

         (a) The  purpose  of the Plan is to  provide a means by which  selected
Employees of and Consultants to the Company, and its Affiliates, may be given an
opportunity to purchase stock of the Company.

         (b) The Company,  by means of the Plan, seeks to retain the services of
persons who are now Employees of or  Consultants  to the Company,  to secure and
retain the services of new Employees and Consultants,  and to provide incentives
for such persons to exert maximum efforts for the success of the Company.

         (c) The Company  intends that the Options  issued under the Plan shall,
in the  discretion  of the Board or any  Committee to which  responsibility  for
administration  of the Plan has been delegated  pursuant to subsection  3(c), be
either Incentive Stock Options or Nonstatutory Stock Options.  All Options shall
be separately  designated  Incentive Stock Options or Nonstatutory Stock Options
at the time of grant,  and in such form as issued  pursuant  to section 6, and a
separate  certificate  or  certificates  will be issued for shares  purchased on
exercise of each type of Option.

2.       DEFINITIONS.

         (a) "Affiliate" means any parent corporation or subsidiary corporation,
whether now or hereafter existing, as those terms are defined in Sections 424(e)
and (f) respectively, of the Code.

         (b) "Board" means the Board of Directors of the Company.

         (c) "Code" means the Internal Revenue Code of 1986, as amended.

         (d) "Committee" means a Committee  appointed by the Board in accordance
with subsection 3(c) of the Plan.

         (e) "Company" means Lynx Therapeutics Inc., a Delaware corporation.

         (f) "Consultant" means any person, including an advisor, engaged by the
Company or an  Affiliate  to render  services  and who is  compensated  for such
services,  provided that the term  "Consultant"  shall not include Directors who
are paid only a director's fee by the Company or who are not  compensated by the
Company for their services as Directors.

         (g)  "Continuous  Status  as  an  Employee  or  Consultant"  means  the
employment or  relationship  as a Consultant is not interrupted or terminated by
the Company or any Affiliate.  The Board, in its sole discretion,  may determine
whether  Continuous  Status as an Employee  or  Consultant  shall be  considered
interrupted  in the case of:  (i) any leave of  absence  approved  by the Board,
including sick leave,  military leave,  or any other personal  leave;  provided,
however,  that for purposes of Incentive  Stock Options,  any such leave may not
exceed ninety (90) days, unless  re-employment upon the expiration of such leave
is guaranteed by contract  (including  certain Company policies) or statute;  or
(ii)  transfers  between  locations  of the  Company  or  between  the  Company,
Affiliates or its successor.


                                       1.
<PAGE>


         (h) "Covered  Employee" means the chief executive  officer and the four
(4)  other  highest   compensated   officers  of  the  Company  for  whom  total
compensation is required to be reported to stockholders  under the Exchange Act,
as determined for purposes of Section 162(m) of the Code.

         (i)  "Director" means a member of the Board.

         (j)  "Disability"  means total and  permanent  disability as defined in
Section 22(e)(3) of the Code.

         (k)  "Employee"  means any person,  including  Officers and  Directors,
employed by the Company or any  Affiliate of the Company.  Neither  service as a
Director nor payment of a director's  fee by the Company  shall be sufficient to
constitute "employment" by the Company.

         (l)  "Exchange  Act"  means the  Securities  Exchange  Act of 1934,  as
amended.

         (m) "Fair Market Value" means,  as of any date, the value of the common
stock of the Company determined as follows:

                  (i) If the  common  stock is listed on any  established  stock
exchange or a national market system,  including without limitation the National
Market System of the National Association of Securities Dealers,  Inc. Automated
Quotation  ("Nasdaq")  System,  the Fair Market Value of a share of common stock
shall be the closing sales price for such stock (or the closing bid, if no sales
were  reported) as quoted on such system or exchange  (or the exchange  with the
greatest volume of trading in common stock) on the last market trading day prior
to the day of  determination,  as reported  in the Wall  Street  Journal or such
other source as the Board deems reliable;

                  (ii) If the common  stock is quoted on the Nasdaq  System (but
not  on  the  National  Market  System  thereof)  or is  regularly  quoted  by a
recognized  securities  dealer but  selling  prices are not  reported,  the Fair
Market  Value of a share of common  stock shall be the mean between the high bid
and high asked prices for the common stock on the last market  trading day prior
to the day of  determination,  as reported  in the Wall  Street  Journal or such
other source as the Board deems reliable;

                  (iii) In the absence of an  established  market for the common
stock, the Fair Market Value shall be determined in good faith by the Board.

         (n) "Incentive  Stock Option" means an Option intended to qualify as an
incentive  stock  option  within the  meaning of Section 422 of the Code and the
regulations promulgated thereunder.

         (o) "Non-Employee  Director" means a Director of the Company who either
(i) is not a current  Employee  or  Officer  of the  Company  or its parent or a
subsidiary,  does not receive  compensation  (directly or  indirectly)  from the
Company or its parent or a subsidiary  for services  rendered as a consultant or
in any  capacity  other  than as a  Director  (except  for an amount as to which
disclosure would not be required under Item 404(a) of Regulation S-K promulgated
pursuant to the Securities Act ("Regulation S-K")), does not possess an interest
in any other  transaction  as to which  disclosure  would be required under Item
404(a) of  Regulation  S-K and is not engaged in a business  relationship  as to
which  disclosure would be required under Item 404(b) of Regulation S-K; or (ii)
is otherwise considered a "non-employee director" for purposes of Rule 16b-3.

         (p) "Nonstatutory Stock Option" means an Option not intended to qualify
as an Incentive Stock Option.

         (q)  "Officer"  means a person who is an officer of the Company  within
the  meaning  of Section 16 of the  Exchange  Act and the rules and  regulations
promulgated thereunder.

         (r) "Option" means a stock option granted pursuant to the Plan.


                                       2.
<PAGE>


         (s) "Option  Agreement" means a written  agreement  between the Company
and an Optionee  evidencing  the terms and  conditions of an  individual  Option
grant. The Option Agreement is subject to the terms and conditions of the Plan.

         (t) "Optioned  Stock" means the common stock of the Company  subject to
an Option.

         (u) "Optionee" means an Employee or Consultant who holds an outstanding
Option.

         (v) "Outside  Director"  means a Director of the Company who either (i)
is not a current employee of the Company or an "affiliated  corporation" (within
the meaning of Treasury  Regulations  promulgated  under  Section  162(m) of the
Code),  is not a former  employee of the Company or an "affiliated  corporation"
receiving  compensation  for prior  services  (other than  benefits  under a tax
qualified  pension  plan),  was not an officer of the Company or an  "affiliated
corporation"  at any time and is not  currently  receiving  direct  or  indirect
remuneration from the Company or an "affiliated corporation" for services in any
capacity  other than as a Director or (ii) is otherwise  considered  an "outside
director" for purposes of Section 162(m) of the Code.

         (w) "Plan" means this 1992 Stock Option Plan.

         (x) "Rule 16b-3" means Rule 16b-3 of the Exchange Act or any  successor
to Rule 16b-3,  as in effect when  discretion is being exercised with respect to
the Plan.

3.       ADMINISTRATION.

         (a) The Plan shall be  administered  by the Board  unless and until the
Board delegates administration to a Committee, as provided in subsection 3(c).

         (b) The  Board  shall  have the  power,  subject  to,  and  within  the
limitations of, the express provisions of the Plan:

                  (i) To  determine  from  time to  time  which  of the  persons
eligible under the Plan shall be granted Options;  when and how the Option shall
be  granted;  whether  the  Option  will  be  an  Incentive  Stock  Option  or a
Nonstatutory Stock Option; the provisions of each Option granted (which need not
be identical), including the time or times such Option may be exercised in whole
or in part;  and the  number of shares  for which an Option  shall be granted to
each such person.

                  (ii) To construe and  interpret  the Plan and Options  granted
under it, and to  establish,  amend and  revoke  rules and  regulations  for its
administration.  The Board,  in the  exercise  of this  power,  may  correct any
defect,  omission or inconsistency in the Plan or in any Option Agreement,  in a
manner and to the extent it shall deem  necessary  or expedient to make the Plan
fully effective.

                  (iii) To amend the Plan as provided in Section 11.

         (c)      Delegation to Committee.

                  (i) General. The Board may delegate administration of the Plan
to a Committee or Committees  of one or more members of the Board,  and the term
"Committee" shall apply to any person or persons to whom such authority has been
delegated.  If administration  is delegated to a Committee,  the Committee shall
have, in connection with the  administration of the Plan, the powers theretofore
possessed by the Board, including the power to delegate to a subcommittee any of
the  administrative   powers  the  Committee  is  authorized  to  exercise  (and
references  in this Plan to the Board shall  thereafter  be to the  Committee or
subcommittee),  subject, however, to such resolutions, not inconsistent with the
provisions  of the Plan,  as may be adopted from time to time by the Board.  The
Board  may  abolish  the  Committee  at any time and  revest  in the  Board  the
administration of the Plan.


                                       3.
<PAGE>


                  (ii)  Committee  Composition  when  Common  Stock is  Publicly
Traded.  At such time as the common stock of the Company is publicly traded,  in
the  discretion  of the Board,  a Committee  may  consist  solely of two or more
Outside Directors,  in accordance with Section 162(m) of the Code, and/or solely
of two or more Non-Employee Directors, in accordance with Rule 16b-3. Within the
scope of such  authority,  the  Board or the  Committee  may (i)  delegate  to a
committee of one or more members of the Board who are not Outside Directors, the
authority  to grant  Options  to  eligible  persons  who are either (a) not then
Covered  Employees  and are not expected to be Covered  Employees at the time of
recognition of income resulting from such Option or (b) not persons with respect
to whom the Company wishes to comply with Section 162(m) of the Code and/or (ii)
delegate  to a  committee  of one or  more  members  of the  Board  who  are not
Non-Employee  Directors the  authority to grant Options to eligible  persons who
are not then subject to Section 16 of the Exchange Act.

4.       SHARES SUBJECT TO THE PLAN.

         (a) Subject to the  provisions  of Section 10  relating to  adjustments
upon changes in stock,  the stock that may be sold pursuant to Options shall not
exceed in the aggregate Four Million  (4,000,000) shares of the Company's common
stock less any shares of the Company's common stock remaining  outstanding which
were  originally  issued to employees,  officers or directors of, or consultants
to, the Company  pursuant to stock purchase  agreements or similar  compensatory
arrangements  approved by the Company's Board of Directors.  If any Option shall
for any reason expire or otherwise  terminate  without  having been exercised in
full, the stock not purchased under such Option shall again become available for
the Plan.

         (b) The stock subject to the Plan may be unissued  shares or reacquired
shares, bought on the market or otherwise.

5.       ELIGIBILITY.

         (a)  Incentive   Stock  Options  may  be  granted  only  to  Employees.
Nonstatutory Stock Options may be granted only to Employees or Consultants.

         (b) No person  shall be eligible  for the grant of an Option if, at the
time of grant,  such person owns (or is deemed to own pursuant to Section 424(d)
of the Code) stock  possessing more than ten percent (10%) of the total combined
voting power of all classes of stock of the Company or of any of its  Affiliates
unless the  exercise  price of such  Option is at least one  hundred ten percent
(110%)  of the  Fair  Market  Value of such  stock at the date of grant  and the
Option is not  exercisable  after the expiration of five (5) years from the date
of grant.

         (c) Section 162(m) Limitation.  Subject to the provisions of Section 10
relating to adjustments  upon changes in stock, no employee shall be eligible to
be granted Options covering more than Five Hundred Thousand  (500,000) shares of
the common stock of the Company during any calendar year.

6.       OPTION PROVISIONS.

         Each  Option  shall be in such form and shall  contain  such  terms and
conditions  as the Board  shall deem  appropriate.  The  provisions  of separate
Options  need  not  be  identical,   but  each  Option  shall  include  (through
incorporation of provisions  hereof by reference in the Option or otherwise) the
substance of each of the following provisions:

         (a) Term. No Option shall be  exercisable  after the  expiration of ten
(10) years from the date it was granted.

         (b) Price.  The exercise price of each Incentive  Stock Option shall be
not less than one hundred  percent  (100%) of the fair market value of the stock
subject to the Option on the date the Option is granted.  The exercise  price of
each Nonstatutory Stock Option shall be not less than eighty-five  percent (85%)
of the fair  market  value of the stock  subject  to the  Option on the date the
Option is granted.


                                       4.
<PAGE>


         (c) Consideration.  The purchase price of stock acquired pursuant to an
Option  shall be paid,  to the  extent  permitted  by  applicable  statutes  and
regulations,  either (i) in cash at the time the option is exercised, or (ii) at
the discretion of the Board or the Committee, either at the time of the grant or
exercise of the Option,  (A) by delivery to the Company of other common stock of
the Company, (B) according to a deferred payment or other arrangement (which may
include,  without  limiting the  generality of the  foregoing,  the use of other
common stock of the Company) with the person to whom the Option is granted or to
whom the Option is transferred  pursuant to subsection 6(d), or (c) in any other
form of legal consideration that may be acceptable to the Board.

         In the case of any  deferred  payment  arrangement,  interest  shall be
payable at least  annually  and shall be charged at the minimum rate of interest
necessary to avoid the treatment as interest, under any applicable provisions of
the Code,  of any amounts  other than  amounts  stated to be interest  under the
deferred payment arrangement.

         (d)   Transferability.   An   Incentive   Stock  Option  shall  not  be
transferable except by will or by the laws of descent and distribution and shall
be  exercisable  during the lifetime of the  Optionee  only by the  Optionee.  A
Nonstatutory  Stock Option shall be  transferable  to the extent provided in the
Option  Agreement.  If the  Nonstatutory  Stock  Option  does  not  provide  for
transferability,  then the  Nonstatutory  Stock Option shall not be transferable
except  by  will  or by the  laws of  descent  and  distribution  and  shall  be
exercisable during the lifetime of the Optionee only by the Optionee.

         (e) Vesting.  The total number of shares of stock  subject to an Option
may,  but need not, be allotted in periodic  installments  (which may,  but need
not, be equal).  The Option  Agreement may provide that from time to time during
each of such installment  periods,  the Option may become  exercisable  ("vest")
with respect to some or all of the shares  allotted to that  period,  and may be
exercised  with  respect to some or all of the shares  allotted  to such  period
and/or any prior period as to which the Option  became  vested but was not fully
exercised.  During the  remainder of the term of the Option (if its term extends
beyond the end of the  installment  periods),  the option may be exercised  from
time to time with  respect to any shares then  remaining  subject to the Option.
The  provisions  of this  subsection  6(e) are subject to any Option  provisions
governing the minimum number of shares as to which an Option may be exercised.

         (f) Securities Law Compliance. The Company may require any Optionee, or
any  person  to whom an  Option  is  transferred  under  subsection  6(d),  as a
condition  of  exercising  any  such  Option,  (1) to  give  written  assurances
satisfactory  to the Company as to the  Optionee's  knowledge and  experience in
financial  and  business  matters  and/or to employ a  purchaser  representative
reasonably  satisfactory to the Company who is knowledgeable  and experienced in
financial  and business  matters,  and that he or she is capable of  evaluating,
alone or together  with the  purchaser  representative,  the merits and risks of
exercising the Option;  and (2) to give written  assurances  satisfactory to the
Company  stating that such person is acquiring  the stock  subject to the Option
for such  person's own account and not with any present  intention of selling or
otherwise  distributing the stock. These requirements,  and any assurances given
pursuant to such  requirements,  shall be inoperative if (i) the issuance of the
shares  upon  the  exercise  of the  Option  has  been  registered  under a then
currently effective  registration statement under the Securities Act of 1933, as
amended (the  "Securities  Act"),  or (ii) as to any particular  requirement,  a
determination  is made by counsel for the Company that such requirement need not
be met in the circumstances under the then applicable securities laws.

         (g) Termination of Employment or  Relationship as a Consultant.  In the
event an Optionee's  Continuous  Status as an Employee or Consultant  terminates
(other than upon the Optionee's death or Disability),  the Optionee may exercise
his or her Option,  but only within such period of time as is  determined by the
Board,  and only to the extent that the  Optionee was entitled to exercise it at
the date of  termination  (but in no event later than the expiration of the term
of  such  Option  as set  forth  in the  Option  Agreement).  In the  case of an
Incentive  Stock Option,  the Board shall  determine  such period of time (in no
event to exceed three (3) months from the date of  termination)  when the Option
is granted.  If, at the date of  termination,  the  Optionee is not  entitled to
exercise  his or her  entire  Option,  the shares  covered by the  unexercisable
portion of the Option  shall  revert to the Plan.  If,  after  termination,  the
Optionee  does not exercise his or her Option  within the time  specified in the
Option  Agreement,  the Option shall  terminate,  and the shares covered by such
Option shall revert to the Plan.


                                       5.
<PAGE>


         (h)  Disability  of  Optionee.  In the event an  Optionee's  Continuous
Status as an Employee or  Consultant  terminates  as a result of the  Optionee's
Disability,  the Optionee may exercise his or her Option, but only within twelve
(12) months from the date of such  termination (or such shorter period specified
in the Option Agreement),  and only to the extent that the Optionee was entitled
to exercise it at the date of such  termination  (but in no event later than the
expiration of the term of such Option as set forth in the Option Agreement). If,
at the date of termination,  the Optionee is not entitled to exercise his or her
entire  Option,  the shares covered by the  unexercisable  portion of the Option
shall revert to the Plan. If, after termination,  the Optionee does not exercise
his or her Option within the time specified herein,  the Option shall terminate,
and the shares covered by such Option shall revert to the Plan.

         (i) Death of Optionee.  In the event of the death of an  Optionee,  the
Option may be  exercised,  at any time within  twelve (12) months  following the
date of death (or such shorter period specified in the Option Agreement) (but in
no event  later than the  expiration  of the term of such Option as set forth in
the Option Agreement),  by the Optionee's estate or by a person who acquired the
right to exercise the Option by bequest or  inheritance,  but only to the extent
the Optionee  was  entitled to exercise the Option at the date of death.  If, at
the time of death,  the  Optionee was not entitled to exercise his or her entire
Option,  the shares  covered by the  unexercisable  portion of the Option  shall
revert to the Plan.  If,  after  death,  the  Optionee's  estate or a person who
acquired  the right to exercise  the Option by bequest or  inheritance  does not
exercise  the  Option  within  the  time  specified  herein,  the  Option  shall
terminate, and the shares covered by such Option shall revert to the Plan.

         (j) Early Exercise.  The Option may, but need not,  include a provision
whereby the  Optionee may elect at any time while an Employee or  Consultant  to
exercise  the Option as to any part or all of the  shares  subject to the Option
prior to the full vesting of the Option. Any unvested shares so purchased may be
subject  to a  repurchase  right  in  favor  of  the  Company  or to  any  other
restriction the Board determines to be appropriate.

         (k)  Withholding.  To the  extent  provided  by the  terms of an Option
Agreement,  the Optionee may satisfy any federal, state or local tax withholding
obligation relating to the exercise of such Option by any of the following means
or by a combination of such means: (1) tendering a cash payment; (2) authorizing
the Company to withhold  shares  from the shares of the common  stock  otherwise
issuable to the  participant  as a result of the exercise of the Option;  or (3)
delivering to the Company owned and  unencumbered  shares of the common stock of
the Company.

7.       COVENANTS OF THE COMPANY.

         (a) During the terms of the Options,  the Company shall keep  available
at all times the number of shares of stock required to satisfy such Options.

         (b) The Company shall seek to obtain from each regulatory commission or
agency having  jurisdiction  over the Plan such  authority as may be required to
issue and sell shares of stock upon exercise of the Options; provided,  however,
that this  undertaking  shall not  require  the  Company to  register  under the
Securities  Act either  the Plan,  any  Option or any stock  issued or  issuable
pursuant to any such Option. If, after reasonable efforts, the Company is unable
to obtain from any such  regulatory  commission  or agency the  authority  which
counsel for the Company  deems  necessary  for the lawful  issuance  and sale of
stock under the Plan,  the  Company  shall be relieved  from any  liability  for
failure to issue and sell stock upon  exercise of such Options  unless and until
such authority is obtained.

8.       USE OF PROCEEDS FROM STOCK.

         Proceeds from the sale of stock  pursuant to Options  shall  constitute
general funds of the Company.


                                       6.
<PAGE>


9.       MISCELLANEOUS.

         (a) Neither an Optionee nor any person to whom an Option is transferred
under subsection 6(d) shall be deemed to be the holder of, or to have any of the
rights of a holder with respect to, any shares subject to such Option unless and
until such person has  satisfied  all  requirements  for  exercise of the Option
pursuant to its terms.

         (b) Nothing in the Plan or any  instrument  executed or Option  granted
pursuant  thereto  shall confer upon any  Employee,  Consultant  or Optionee any
right to continue in the employ of the Company or any  Affiliate (or to continue
acting  as a  Consultant)  or  shall  affect  the  right of the  Company  or any
Affiliate to terminate  the  employment or  relationship  as a Consultant of any
Employee, Consultant or Optionee with or without cause.

         (c) To the extent that the aggregate  Fair Market Value  (determined at
the time of  grant) of stock  with  respect  to which  Incentive  Stock  Options
granted after 1986 are exercisable for the first time by any Optionee during any
calendar  year under all plans of the  Company  and its  Affiliates  exceeds one
hundred  thousand  dollars  ($100,000),  the Options or portions  thereof  which
exceed such limit  (according to the order in which they were granted)  shall be
treated as Nonstatutory Stock Options.

10.      ADJUSTMENTS UPON CHANGES IN STOCK.

         (a) If any  change is made in the stock  subject to the Plan or subject
to any Option  without the  receipt of  consideration  by the  Company  (through
merger, consolidation, reorganization, recapitalization,  reincorporation, stock
dividend,  dividend  in  property  other than  cash,  stock  split,  liquidating
dividend,  combination  of  shares,  exchange  of  shares,  change in  corporate
structure or other transaction not involving the receipt of consideration by the
Company),  the Plan will be appropriately  adjusted in the class(es) and maximum
number of securities  subject to the Plan  pursuant to  subsection  4(a) and the
maximum  number  of  securities  subject  to award  to any  person  pursuant  to
subsection 5(c), and outstanding  Options will be appropriately  adjusted in the
class(es) and number of securities  and price per share of stock subject to such
outstanding  Options.   Such  adjustments  shall  be  made  by  the  Board,  the
determination of which shall be final,  binding and conclusive.  (The conversion
of any  convertible  securities  of  the  Company  shall  not  be  treated  as a
transaction "without receipt of consideration" by the Company.)

         (b) In the event of: (1) a merger or consolidation in which the Company
is not the surviving corporation or (2) a reverse merger in which the Company is
the  surviving  corporation  but  the  shares  of  the  Company's  common  stock
outstanding  immediately  preceding  the merger are  converted  by virtue of the
merger into other property, whether in the form of securities, cash or otherwise
then to the extent  permitted by applicable  law: (i) any surviving  corporation
shall assume any Options  outstanding under the Plan or shall substitute similar
Options  for  those  outstanding  under the Plan,  or (ii)  such  Options  shall
continue  in full  force and  effect.  In the event  any  surviving  corporation
refuses to assume or continue such Options, or to substitute similar options for
those  outstanding  under the Plan, then such Options shall be terminated if not
exercised  prior to such event.  In the event of a dissolution or liquidation of
the  Company,  any Options  outstanding  under the Plan shall  terminate  if not
exercised prior to such event.

11.      AMENDMENT OF THE PLAN.

         (a) The Board at any time,  and from time to time,  may amend the Plan.
However,  except as provided in Section 10 relating to adjustments  upon changes
in stock, no amendment shall be effective unless approved by the stockholders of
the  Company  within  twelve  (12)  months  before or after the  adoption of the
amendment,  to the extent  stockholder  approval  is  necessary  to satisfy  the
requirements  of Section 422 of the Code, Rule 16b-3 or any Nasdaq or securities
exchange listing requirements.

         (b) The Board may, in its sole  discretion,  submit any other amendment
to the Plan for stockholder approval,  including, but not limited to, amendments
to the Plan intended to satisfy the  requirements  of Section 162(m) of the Code
and the  regulations  thereunder  regarding the  exclusion of  performance-based
compensation  from the limit on corporate  deductibility of compensation paid to
certain executive officers.


                                       7.
<PAGE>

         (c) It is expressly  contemplated  that the Board may amend the Plan in
any respect the Board deems necessary or advisable to provide Optionees with the
maximum benefits provided or to be provided under the provisions of the Code and
the  regulations  promulgated  thereunder  relating to Incentive  Stock  Options
and/or to bring the Plan and/or  Incentive  Stock Options  granted under it into
compliance therewith.

         (d) Rights and obligations under any Option granted before amendment of
the Plan shall not be altered or  impaired by any  amendment  of the Plan unless
(i) the  Company  requests  the  consent  of the  person to whom the  Option was
granted and (ii) such person consents in writing.

12.      TERMINATION OR SUSPENSION OF THE PLAN.

         (a) The Board may  suspend or  terminate  the Plan at any time.  Unless
sooner terminated, the Plan shall terminate on March 11, 2006. No Options may be
granted under the Plan while the Plan is suspended or after it is terminated.

         (b) Rights and  obligations  under any Option granted while the Plan is
in effect shall not be altered or impaired by suspension or  termination  of the
Plan, except with the consent of the person to whom the Option was granted.

13.      EFFECTIVE DATE OF PLAN.

The Plan shall  become  effective  as  determined  by the Board,  but no Options
granted  under the Plan  shall be  exercised  unless and until the Plan has been
approved by the  stockholders of the Company,  and, if required,  an appropriate
permit  has been  issued by the  Commissioner  of  Corporations  of the State of
California.


                                       8.
<PAGE>
                            LYNX THERAPEUTICS, INC.

                        1998 EMPLOYEE STOCK PURCHASE PLAN

                            Adopted February 26, 1998
                Approved by the Stockholders on ___________, 1998

1.       PURPOSE.

         (a) The purpose of this 1998 Employee  Stock Purchase Plan (the "Plan")
is to provide a means by which employees of Lynx Therapeutics,  Inc., a Delaware
corporation  (the  "Company"),  and its  Affiliates,  as defined in subparagraph
1(b),  which are  designated as provided in  subparagraph  2(b), may be given an
opportunity to purchase stock of the Company.

         (b)  The  word  "Affiliate"  as  used  in the  Plan  means  any  parent
corporation or subsidiary corporation of the Company, as those terms are defined
in Sections 424(e) and (f), respectively,  of the Internal Revenue Code of 1986,
as amended (the "Code").

         (c) The Company,  by means of the Plan, seeks to retain the services of
its  employees,  to secure and  retain the  services  of new  employees,  and to
provide  incentives for such persons to exert maximum efforts for the success of
the Company.

         (d) The  Company  intends  that the  rights  to  purchase  stock of the
Company  granted under the Plan be considered  options issued under an "employee
stock purchase plan" as that term is defined in Section 423(b) of the Code.

2.       ADMINISTRATION.

         (a) The Plan  shall be  administered  by the  Board of  Directors  (the
"Board") of the Company unless and until the Board delegates administration to a
committee  as  provided  in  subparagraph  2(c).  Whether  or not the  Board has
delegated  administration  the Board shall have the final power to determine all
questions of policy and expediency that may arise in the  administration  of the
Plan.

         (b) The  Board  shall  have the  power,  subject  to,  and  within  the
limitations of, the express provisions of the Plan:

                  (i) To determine  when and how rights to purchase stock of the
Company  shall be granted  and the  provisions  of each  offering of such rights
(which need not be identical).

                  (ii) To designate  from time to time which  Affiliates  of the
Company shall be eligible to participate in the Plan.

                  (iii) To construe and  interpret  the Plan and rights  granted
under it, and to  establish,  amend and  revoke  rules and  regulations  for its
administration.  The Board,  in the  exercise  of this  power,  may  correct any
defect,  omission or inconsistency in the Plan, in a manner and to the extent it
shall deem necessary or expedient to make the Plan fully effective.

                  (iv) To amend the Plan as provided in paragraph 13.

                  (v)  Generally,  to exercise  such powers and to perform  such
acts as the Board or the Committee  deems  necessary or expedient to promote the
best  interests  of the Company and its  Affiliates  and to carry out the intent
that the Plan be treated as an "employee stock purchase plan" within the meaning
of Section 423 of the Code.


                                       1.
<PAGE>


         (c) The Board may  delegate  administration  of the Plan to a committee
composed  of not fewer than two (2) members of the Board (the  "Committee").  If
administration  is  delegated  to a  Committee,  the  Committee  shall have,  in
connection with the administration of the Plan, the powers theretofore possessed
by the board, subject,  however, to such resolutions,  not inconsistent with the
provisions  of the Plan,  as may be adopted from time to time by the Board.  The
Board  may  abolish  the  Committee  at any time and  revest  in the  Board  the
administration of the Plan.

3.       SHARES SUBJECT TO THE PLAN.

         (a) Subject to the  provisions of paragraph 12 relating to  adjustments
upon  changes in stock,  the stock that may be sold  pursuant to rights  granted
under the Plan shall not exceed in the aggregate two hundred thousand  (200,000)
shares of the Company's common stock (the "Common Stock").  If any right granted
under the Plan shall for any reason terminate without having been exercised, the
Common Stock not purchased under such right shall again become available for the
Plan.

         (b) The stock subject to the Plan may be unissued  shares or reacquired
shares, bought on the market or otherwise.

4.       GRANT OF RIGHTS; OFFERING.

         (a) The Board or the  Committee  may from time to time grant or provide
for the grant of rights to purchase  Common Stock of the Company  under the Plan
to  eligible  employees  (an  "Offering")  on a date  or  dates  (the  "Offering
Date(s)") selected by the Board or the Committee. Each Offering shall be in such
form and shall  contain such terms and  conditions as the Board or the Committee
shall deem  appropriate,  which shall  comply with the  requirements  of Section
423(b)(5) of the Code that all employees  granted rights to purchase stock under
the Plan shall have the same rights and privileges.  The terms and conditions of
an Offering shall be incorporated by reference into the Plan and treated as part
of the Plan.  The provisions of separate  Offerings  need not be identical,  but
each Offering  shall include  (through  incorporation  of the provisions of this
Plan by reference  in the document  comprising  the Offering or  otherwise)  the
period  during which the  Offering  shall be  effective,  which period shall not
exceed  twenty-seven  (27) months  beginning  with the  Offering  Date,  and the
substance of the provisions contained in paragraphs 5 through 8, inclusive.

         (b) If an employee has more than one right  outstanding under the Plan,
unless  he or  she  otherwise  indicates  in  agreements  or  notices  delivered
hereunder:  (1) each  agreement  or notice  delivered by that  employee  will be
deemed to apply to all of his or her rights under the Plan, and (2) a right with
a  lower  exercise  price  (or an  earlier-granted  right,  if two  rights  have
identical  exercise  prices),  will be exercised to the fullest  possible extent
before a right with a higher  exercise price (or a  later-granted  right, if two
rights have identical exercise prices) will be exercised.

5.       ELIGIBILITY.

         (a) Rights may be granted  only to  employees of the Company or, as the
Board or the  Committee  may  designate  as provided in  subparagraph  2(b),  to
employees of any  Affiliate of the Company.  Except as provided in  subparagraph
5(b),  an employee of the Company or any  Affiliate  shall not be eligible to be
granted rights under the Plan unless,  on the Offering  Date,  such employee has
been in the employ of the Company or any  Affiliate for such  continuous  period
preceding such grant as the Board or the Committee may require,  but in no event
shall the required  period of continuous  employment be equal to or greater than
two (2) years.  In addition,  unless  otherwise  determined  by the Board or the
Committee and set forth in the terms of the applicable Offering,  no employee of
the Company or any  Affiliate  shall be eligible to be granted  rights under the
Plan unless, on the Offering Date, such employee's customary employment with the
Company  or such  Affiliate  is for at least  twenty  (20) hours per week and at
least five (5) months per calendar year.

         (b) The Board or the Committee may provide that each person who, during
the course of an Offering,  first becomes an eligible employee of the Company or
designated  Affiliate  will, on a date or dates  specified in the


                                       2.
<PAGE>

Offering  which  coincides with the day on which such person becomes an eligible
employee or occurs thereafter,  receive a right under that Offering, which right
shall thereafter be deemed to be a part of that Offering.  Such right shall have
the same  characteristics  as any rights originally granted under that Offering,
as described herein, except that:

                  (i) the  date on which  such  right  is  granted  shall be the
"Offering Date" of such right for all purposes,  including  determination of the
exercise price of such right;

                  (ii) the  period of the  Offering  with  respect to such right
shall  begin  on its  Offering  Date  and end  coincident  with  the end of such
Offering; and

                  (iii)  the Board or the  Committee  may  provide  that if such
person  first  becomes an eligible  employee  within a specified  period of time
before the end of the Offering,  he or she will not receive any right under that
Offering.

         (c) No employee shall be eligible for the grant of any rights under the
Plan if, immediately after any such rights are granted, such employee owns stock
possessing five percent (5%) or more of the total combined voting power or value
of all classes of stock of the Company or of any Affiliate. For purposes of this
subparagraph  5(c),  the  rules of  Section  424(d) of the Code  shall  apply in
determining the stock  ownership of any employee,  and stock which such employee
may purchase under all outstanding  rights and options shall be treated as stock
owned by such employee.

         (d) An eligible  employee may be granted  rights under the Plan only if
such  rights,  together  with any other rights  granted  under  "employee  stock
purchase  plans" of the  Company and any  Affiliates,  as  specified  by Section
423(b)(8) of the Code, do not permit such employee's rights to purchase stock of
the  Company  or any  Affiliate  to accrue at a rate which  exceeds  twenty-five
thousand dollars ($25,000) of fair market value of such stock (determined at the
time such rights are  granted) for each  calendar  year in which such rights are
outstanding at any time.

         (e)  Officers  of the  Company and any  designated  Affiliate  shall be
eligible to participate in Offerings under the Plan, provided, however, that the
Board or the Committee may provide in an Offering that certain employees who are
highly compensated  employees within the meaning of Section  423(b)(4)(D) of the
Code shall not be eligible to participate.

6.       RIGHTS; PURCHASE PRICE.

         (a) On each  Offering  Date,  each  eligible  employee,  pursuant to an
Offering  made under the Plan,  shall be granted the right to purchase up to the
number of shares of Common  Stock of the Company  purchasable  with a percentage
designated by the Board or the Committee not exceeding ten percent (10%) of such
employee's  Earnings (as by the Board for each Offering) during the period which
begins on the  Offering  Date (or such later date as the Board or the  Committee
determines  for a  particular  Offering)  and  ends on the  date  stated  in the
Offering,  which date shall be no later than the end of the Offering.  The Board
or the  Committee  shall  establish  one or more dates  during an Offering  (the
"Purchase  Date(s)") on which rights  granted  under the Plan shall be exercised
and purchases of Common Stock carried out in accordance with such Offering.

         (b) In connection  with each Offering made under the Plan, the Board or
the  Committee  may specify a maximum  number of shares that may be purchased by
any  employee  as well as a  maximum  aggregate  number  of  shares  that may be
purchased by all eligible employees pursuant to such Offering.  In addition,  in
connection  with each Offering that  contains more than one Purchase  Date,  the
Board or the  Committee may specify a maximum  aggregate  number of shares which
may be purchased by all eligible  employees on any given Purchase Date under the
Offering.  If the aggregate  purchase of shares upon exercise of rights  granted
under the Offering would exceed any such maximum aggregate number,  the Board or
the Committee  shall make a pro rata  allocation  of the shares  available in as
nearly a  uniform  manner  as shall be  practicable  and as it shall  deem to be
equitable.


                                       3.
<PAGE>


         (c) The purchase  price of stock  acquired  pursuant to rights  granted
under the Plan shall be not less than the lesser of:

                   (i) an amount equal to eighty-five  percent (85%) of the fair
market value of the stock on the Offering Date; or

                   (ii) an amount equal to eighty-five percent (85%) of the fair
market value of the stock on the Purchase Date.

7.       PARTICIPATION; WITHDRAWAL; TERMINATION.

         (a) An eligible  employee may become a participant in the Plan pursuant
to an Offering by delivering a participation agreement to the Company within the
time specified in the Offering, in such form as the Company provides.  Each such
agreement shall  authorize  payroll  deductions of up to the maximum  percentage
specified by the Board or the Committee of such employee's  Earnings (as defined
by the Board for each Offering) during the Offering. The payroll deductions made
for each participant  shall be credited to an account for such participant under
the Plan and  shall  be  deposited  with the  general  funds of the  Company.  A
participant may reduce (including to zero) or increase such payroll  deductions,
and an eligible employee may begin such payroll deductions,  after the beginning
of any Offering  only as provided for in the Offering.  A  participant  may make
additional payments into his or her account only if specifically provided for in
the Offering and only if the participant has not had the maximum amount withheld
during the Offering.

         (b) At any time during an Offering,  a participant may terminate his or
her  payroll  deductions  under  the Plan and  withdraw  from  the  Offering  by
delivering  to the  Company a notice of  withdrawal  in such form as the Company
provides.  Such  withdrawal  may be  elected at any time prior to the end of the
Offering except as provided by the Board or the Committee in the Offering.  Upon
such withdrawal from the Offering by a participant, the Company shall distribute
to such participant all of his or her accumulated payroll deductions (reduced to
the extent,  if any,  such  deductions  have been used to acquire  stock for the
participant) under the Offering,  without interest, and such participant's right
to acquire Common Stock under that Offering shall be automatically terminated. A
participant's  withdrawal  from an  Offering  will  have  no  effect  upon  such
participant's  eligibility to participate in any other  Offerings under the Plan
but such participant will be required to deliver a new  participation  agreement
in order to participate in subsequent Offerings under the Plan.

         (c) Rights  granted  pursuant  to any  Offering  under  the Plan  shall
terminate  immediately  upon cessation of a  participant's  employment  with the
Company and any  designated  Affiliate,  for any reason,  and the Company  shall
distribute to such  terminated  employee all of his or her  accumulated  payroll
deductions  (reduced to the extent,  if any, such  deductions  have been used to
acquire  stock  for  the  terminated  employee),  under  the  Offering,  without
interest.

         (d) Rights  granted  under  the Plan  shall  not be  transferable  by a
participant other than by will or the laws of descent and distribution,  or by a
beneficiary  designation as provided in paragraph 14, and during a participant's
lifetime, shall be exercisable only by such participant.

8.       EXERCISE.

         (a) On each date specified therefor in the relevant Offering ("Purchase
Date"),  each participant's  accumulated payroll deductions and other additional
payments  specifically  provided for in the  Offering  (without any increase for
interest)  will be  applied  to the  purchase  of whole  shares  of stock of the
Company,  up to the maximum number of shares permitted  pursuant to the terms of
the Plan and the applicable  Offering,  at the purchase  price  specified in the
Offering.   Unless  otherwise  provided  for  in  the  applicable  Offering,  no
fractional  shares shall be issued upon the exercise of rights granted under the
Plan. The amount, if any, of accumulated  payroll  deductions  remaining in each
participant's account after the purchase of shares which is less than the amount
required  to  purchase  one  share  of stock on the  final  Purchase  Date of an
Offering  shall be held in each such  participant's  account for the purchase of
shares under the next Offering under the Plan, unless such participant withdraws
from


                                       4.
<PAGE>

such next Offering,  as provided in subparagraph  7(b), or is no longer eligible
to be granted  rights under the Plan,  as provided in paragraph 5, in which case
such amount shall be  distributed to the  participant  after such final Purchase
Date,  without interest.  The amount, if any, of accumulated  payroll deductions
remaining in any participant's account on the final Purchase Date of an Offering
after the  purchase of shares which is equal to or in excess of the value of one
whole share of common  stock  shall be  distributed  in full to the  participant
after such Purchase Date, without interest.

         (b) No rights  granted  under the Plan may be  exercised  to any extent
unless  the shares to be issued  upon such  exercise  under the Plan  (including
rights granted  thereunder) are covered by an effective  registration  statement
pursuant to the  Securities Act of 1933, as amended (the  "Securities  Act") and
the Plan is in material compliance with all applicable state,  foreign and other
securities  and other laws  applicable to the Plan. If on a Purchase Date in any
Offering  hereunder  the Plan is not so  registered  or in such  compliance,  no
rights  granted  under  the  Plan or any  Offering  shall be  exercised  on such
Purchase  Date, and the Purchase Date shall be delayed until the Plan is subject
to such an effective registration statement and such compliance, except that the
Purchase Date shall not be delayed more than twelve (12) months and the Purchase
Date shall in no event be more than  twenty-seven  (27) months from the Offering
Date.  If on the  Purchase  Date of any  Offering  hereunder,  as delayed to the
maximum extent  permissible,  the Plan is not registered and in such compliance,
no rights  granted  under the Plan or any Offering  shall be  exercised  and all
payroll  deductions  accumulated  during the Offering (reduced to the extent, if
any, such  deductions  have been used to acquire  stock) shall be distributed to
the participants, without interest.

9.       COVENANTS OF THE COMPANY.

         (a) During the terms of the rights  granted under the Plan, the Company
shall at all times keep available as authorized but unissued  shares that number
of shares of stock required to satisfy such rights.

         (b) The Company shall seek to obtain from each federal,  state, foreign
or other regulatory  commission or agency having jurisdiction over the Plan such
authority as may be required to issue and sell shares of stock upon  exercise of
the rights granted under the Plan. If, after reasonable efforts,  the Company is
unable to obtain from any such  regulatory  commission  or agency the  authority
which counsel for the Company deems  necessary for the lawful  issuance and sale
of stock under the Plan,  the Company  shall be relieved  from any liability for
failure to issue and sell stock upon  exercise of such  rights  unless and until
such authority is obtained.

10.      USE OF PROCEEDS FROM STOCK.

         Proceeds  from the sale of stock to  participants  pursuant  to  rights
granted under the Plan shall constitute general funds of the Company.

11.      RIGHTS AS A STOCKHOLDER.

         A  participant  shall not be deemed to be the holder of, or to have any
of the rights of a holder with respect to, any shares  subject to rights granted
under the Plan unless and until the participant's  shares acquired upon exercise
of rights  hereunder  are  recorded in the books of the Company (or its transfer
agent).


                                       5.
<PAGE>


12.      ADJUSTMENTS UPON CHANGES IN STOCK.

         (a) If any change is made in the stock  subject to the Plan, or subject
to  any  rights   granted  under  the  Plan  (through   merger,   consolidation,
reorganization,  recapitalization,  stock  dividend,  dividend in property other
than cash, stock split, liquidating dividend, combination of shares, exchange of
shares,  change in corporate  structure or other  transaction  not involving the
receipt of consideration by the Company),  the Plan and outstanding  rights will
be appropriately  adjusted in the class(es) and maximum number of shares subject
to the Plan and the  class(es) and number of shares and price per share of stock
subject to outstanding  rights.  Such adjustments  shall be made by the Board or
the  Committee,   the  determination  of  which  shall  be  final,  binding  and
conclusive.  (The conversion of any convertible  securities of the Company shall
not be treated as a "transaction  not involving the receipt of  consideration by
the Company.")

         (b) In the event of: (1) a dissolution  or  liquidation of the Company;
(2) a  merger  or  consolidation  in  which  the  Company  is not the  surviving
corporation;  (3) a  reverse  merger  in  which  the  Company  is the  surviving
corporation but the shares of Common Stock outstanding immediately preceding the
merger are converted by virtue of the merger into other property, whether in the
form of  securities,  cash or otherwise;  or (4) the  acquisition by any person,
entity or group within the meaning of Section  13(d) or 14(d) of the  Securities
Exchange  Act of 1934,  as  amended  (the  "Exchange  Act"),  or any  comparable
successor  provisions  (excluding  any employee  benefit plan, or related trust,
sponsored or  maintained  by the Company or any Affiliate of the Company) of the
beneficial  ownership  (within the meaning of Rule 13d-3  promulgated  under the
Exchange  Act,  or  comparable  successor  rule) of  securities  of the  Company
representing  at least fifty percent (50%) of the combined voting power entitled
to vote in the election of  directors,  then,  as determined by the Board in its
sole   discretion  (i)  any  surviving  or  acquiring   corporation  may  assume
outstanding  rights or substitute  similar rights for those under the Plan, (ii)
such  rights may  continue  in full  force and  effect,  or (iii)  participants'
accumulated  payroll deductions may be used to purchase Common Stock immediately
prior to the transaction  described above and the participants' rights under the
ongoing Offering terminated.

13.      AMENDMENT OF THE PLAN.

         (a) The Board or the Committee at any time,  and from time to time, may
amend  the Plan.  However,  except as  provided  in  paragraph  12  relating  to
adjustments  upon  changes in stock,  no  amendment  shall be  effective  unless
approved by the  stockholders of the Company within twelve (12) months before or
after the  adoption of the  amendment  if such  amendment  requires  stockholder
approval in order for the Plan to obtain  employee stock purchase plan treatment
under Section 423 of the Code or to comply with the  requirements  of Rule 16b-3
promulgated under the Exchange Act.

         (b) The Board or the  Committee  may amend the Plan in any  respect the
Board  or the  Committee  deems  necessary  or  advisable  to  provide  eligible
employees  with the  maximum  benefits  provided  or to be  provided  under  the
provisions of the Code and the regulations  promulgated  thereunder  relating to
employee  stock  purchase  plans and/or to bring the Plan and/or rights  granted
under it into compliance therewith.

         (c) Rights and obligations under any rights granted before amendment of
the Plan shall not be altered or impaired by any  amendment of the Plan,  except
with the consent of the person to whom such rights  were  granted,  or except as
necessary  to comply  with any laws or  governmental  regulations,  or except as
necessary to ensure that the Plan and/or  rights  granted  under the Plan comply
with the requirements of Section 423 of the Code.

14.      DESIGNATION OF BENEFICIARY.

         (a) A participant  may file a written  designation of a beneficiary who
is to receive any shares and cash, if any, from the participant's  account under
the Plan in the event of such  participant's  death  subsequent to the end of an
Offering but prior to delivery to the  participant  of such shares and cash.  In
addition,  a participant may file a written  designation of a beneficiary who is
to receive any cash from the  participant's  account under the Plan in the event
of such participant's death during an Offering.


                                       6.
<PAGE>

         (b) Such  designation of beneficiary  may be changed by the participant
at any time by written  notice in the form  prescribed  by the  Company.  In the
event of the death of a participant and in the absence of a beneficiary  validly
designated under the Plan who is living at the time of such participant's death,
the  Company   shall  deliver  such  shares  and/or  cash  to  the  executor  or
administrator  of the  estate  of the  participant,  or if no such  executor  or
administrator has been appointed (to the knowledge of the Company), the Company,
in its sole discretion,  may deliver such shares and/or cash to the spouse or to
any one or more  dependents  or relatives of the  participant,  or if no spouse,
dependent or relative is known to the Company,  then to such other person as the
Company may designate.

15.      TERMINATION OR SUSPENSION OF THE PLAN.

         (a) The  Board or the  Committee  in its  discretion,  may  suspend  or
terminate  the Plan at any time.  No rights may be granted  under the Plan while
the Plan is suspended or after it is terminated.

         (b) Rights and  obligations  under any rights granted while the Plan is
in effect shall not be altered or impaired by suspension or  termination  of the
Plan, except as expressly provided in the Plan or with the consent of the person
to whom such rights were granted, or except as necessary to comply with any laws
or  governmental  regulation,  or except as  necessary  to ensure  that the Plan
and/or rights granted under the Plan comply with the requirements of Section 423
of the Code.

16.      EFFECTIVE DATE OF PLAN.

         The Plan  shall  become  effective  upon  adoption  by the  Board  (the
"Effective  Date"),  but no rights  granted  under the Plan  shall be  exercised
unless and until the Plan has been approved by the  stockholders  of the Company
within  twelve (12)  months  before or after the date the Plan is adopted by the
Board, which date may be prior to the Effective Date.




© 2022 IncJournal is not affiliated with or endorsed by the U.S. Securities and Exchange Commission