LYNX THERAPEUTICS INC
DEF 14A, 1999-04-14
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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                            SCHEDULE 14A INFORMATION

          PROXY STATEMENT PURSUANT TO SECTION 14(A) OF THE SECURITIES
                    EXCHANGE ACT OF 1934 (AMENDMENT NO.   )

Filed by the Registrant                    [X]

Filed by a Party other than the Registrant [ ]

Check the appropriate box:
[ ]  Preliminary Proxy Statement       [ ]  Soliciting Material Pursuant to
                                            sec.240.14a-11(c) or sec.240.14a-12
[X]  Definitive Proxy Statement        [ ]  Confidential, for Use of the
                                            Commission Only
[ ]  Definitive Additional Materials        (as permitted by Rule 14a-6(e)(2))


                            Lynx Therapeutics, Inc.
            ------------------------------------------------
            (Name of Registrant as Specified in Its Charter)


  ------------------------------------------------------------------------
  (Name of Person(s) Filing Proxy Statement, if other than the Registrant)


Payment of filing fee (Check the appropriate box):

[X]  No fee required.
[ ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4) and 0-11.


(1)  Title of each class of securities to which transactions applies:

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(2)  Aggregate number of securities to which transactions applies:

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(3)   Per unit price or other underlying value of transaction  computed pursuant
      to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is
      calculated and state how it was determined):

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(4)   Proposed maximum aggregate value of transaction:

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(5)   Total fee paid:

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[ ]   Fee paid previously with preliminary materials.
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[ ]   Check box if any part of the fee is offset as  provided  by  Exchange  Act
      Rule  0-11(a)(2)  and identify the filing for which the offsetting fee was
      paid  previously.  Identify the previous filing by registration  statement
      number, or the Form or Schedule and the date of its filing.

(1)   Amount previously paid:

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(2)   Form, Schedule or Registration Statement No.:

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(3)  Filing party:

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(4)  Date filed:

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                             LYNX THERAPEUTICS, INC.
                              25861 Industrial Blvd.
                            Hayward, California 94545

                    NOTICE OF ANNUAL MEETING OF STOCKHOLDERS 
                           TO BE HELD ON MAY 12, 1999


TO THE STOCKHOLDERS OF LYNX THERAPEUTICS, INC.:

        NOTICE IS HEREBY GIVEN that the Annual Meeting of Stockholders of Lynx 
Therapeutics, Inc., a Delaware corporation (the "Company"), will be held 
on Wednesday, May 12, 1999 at 9:00 a.m., local time, at the Company's 
principal executive offices, located at 25861 Industrial Blvd., Hayward, 
California 94545, for the following purposes:

        1.      To elect directors to serve for the ensuing year and until 
their successors are elected.

        2.      To approve the Company's 1992 Stock Option Plan, as amended, 
to increase the aggregate number of shares of Common Stock 
authorized for issuance under such plan by 200,000 shares and 
to amend certain eligibility and change of control provisions 
of such plan.

        3.      To ratify the selection of Ernst & Young LLP as independent 
auditors of the Company for its fiscal year ending December 
31, 1999.

        4.      To transact such other business as may properly come before 
the meeting or any adjournment or postponement thereof.

        The foregoing items of business are more fully described in the 
Proxy Statement accompanying this Notice.

        The Board of Directors has fixed the close of business on March 22, 
1999, as the record date for the determination of stockholders entitled to 
notice of and to vote at this Annual Meeting and at any adjournment or 
postponement thereof.

                                  By Order of the Board of Directors

                                          [SIGNATURE]

                                  Edward C. Albini,
                                  Secretary

Hayward, California
April 14, 1999








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ALL STOCKHOLDERS ARE CORDIALLY INVITED TO ATTEND THE MEETING IN PERSON.  
WHETHER OR NOT YOU EXPECT TO ATTEND THE MEETING, PLEASE COMPLETE, DATE, SIGN 
AND RETURN THE ENCLOSED PROXY AS PROMPTLY AS POSSIBLE IN ORDER TO ENSURE 
YOUR REPRESENTATION AT THE MEETING.  A RETURN ENVELOPE (WHICH IS POSTAGE 
PREPAID IF MAILED IN THE UNITED STATES) IS ENCLOSED FOR THAT PURPOSE.  EVEN 
IF YOU HAVE GIVEN YOUR PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND THE 
MEETING.  PLEASE NOTE, HOWEVER, THAT IF YOUR SHARES ARE HELD OF RECORD BY A 
BROKER, BANK OR OTHER NOMINEE AND YOU WISH TO VOTE AT THE MEETING, YOU MUST 
OBTAIN FROM THE RECORD HOLDER A PROXY ISSUED IN YOUR NAME.
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<PAGE>








































                           LYNX THERAPEUTICS, INC.
                           25861 Industrial Blvd.
                          Hayward, California  94545

                              PROXY STATEMENT

                      FOR ANNUAL MEETING OF STOCKHOLDERS
                                MAY 12, 1999

                INFORMATION CONCERNING SOLICITATION AND VOTING

General

        The enclosed proxy is solicited on behalf of the Board of Directors 
of Lynx Therapeutics, Inc., a Delaware corporation ("Lynx" or the 
"Company"), for use at the Annual Meeting of Stockholders to be held on 
May 12, 1999, at 9:00 a.m., local time (the "Annual Meeting"), or at any 
adjournment or postponement thereof, for the purposes set forth herein and 
in the accompanying Notice of Annual Meeting.  The Annual Meeting will be 
held at the Company's principal executive offices, located at 25861 
Industrial Blvd., Hayward, California.  The Company intends to mail this 
proxy statement and accompanying proxy card on or about April 14, 1999, to 
all stockholders entitled to vote at the Annual Meeting.

Solicitation

        The Company will bear the entire cost of solicitation of proxies 
including preparation, assembly, printing and mailing of this proxy 
statement, the proxy and any additional information furnished to 
stockholders.  Copies of solicitation materials will be furnished to 
banks, brokerage houses, fiduciaries and custodians holding in their names 
shares of the Company's common stock (the "Common Stock") beneficially 
owned by others to forward to such beneficial owners.  The Company may 
reimburse persons representing beneficial owners of Common Stock for their 
costs of forwarding solicitation materials to such beneficial owners.  
Original solicitation of proxies by mail may be supplemented by telephone, 
telegram or personal solicitation by directors, officers or other regular 
employees of the Company.  No additional compensation will be paid to 
directors, officers or other regular employees for such services.

Voting Rights and Outstanding Shares

        Only holders of record of Common Stock at the close of business on 
March 22, 1999, will be entitled to notice of and to vote at the Annual 
Meeting.  At the close of business on March 22, 1999, the Company had 
outstanding 11,144,739 shares of Common Stock.  Each holder of record of 
Common Stock on such date will be entitled to one vote for each share held 
on all matters to be voted upon at the Annual Meeting.  

        All votes will be tabulated by the inspector of election appointed 
for the meeting, who will separately tabulate affirmative and negative 
votes, abstentions and broker non-votes.  Abstentions will be counted 
towards the tabulation of votes cast on proposals presented to the 
stockholders and will have the same effect as negative votes.  Broker non-
votes are counted towards a quorum, but are not counted for any purpose in 
determining whether a matter has been approved.

Revocability of Proxies

        Any person giving a proxy pursuant to this solicitation has the 
power to revoke it at any time before it is voted.  It may be revoked by 
filing with the Secretary of the Company at the Company's principal 
executive office, 25861 Industrial Blvd., Hayward, California 94545, a 
written notice of revocation or a duly executed proxy bearing a later 
date, or it may be revoked by attending the meeting and voting in person.  
Attendance at the meeting will not, by itself, revoke a proxy.


Stockholder Proposals

        The deadline for submitting a stockholder proposal for inclusion in 
the Company's proxy statement and form of proxy for the Company's 2000 
annual meeting of stockholders pursuant to Rule 14a-8 of the Securities 
and Exchange Commission is December 15, 1999.  Unless a stockholder who 
wishes to bring a matter before the stockholders at the Company's 2000 
annual meeting of stockholders notifies the Company of such matter prior 
to February 28, 2000, management will have discretionary authority to vote 
all shares for which it has proxies in opposition to such matter.  
Stockholders are also advised to review the Company's Bylaws, which 
contain additional requirements with respect to advance notice of 
stockholder proposal and director nominations.


                                  PROPOSAL 1

                             ELECTION OF DIRECTORS

        There are six nominees for the six Board positions presently 
authorized in the Company's By-laws.  Each director to be elected will 
hold office until the next annual meeting of stockholders and until his 
successor is elected and has qualified, or until such director's earlier 
death, resignation or removal.  Each nominee listed below is currently a 
director of the Company who was previously elected by the stockholders.

        Shares represented by executed proxies will be voted, if authority 
to do so is not withheld, for the election of the six nominees named 
below.  In the event that any nominee should be unavailable for election 
as a result of an unexpected occurrence, such shares will be voted for the 
election of such substitute nominee as management may propose.  Each 
person nominated for election has agreed to serve if elected, and 
management has no reason to believe that any nominee will be unable to 
serve. 

        Directors are elected by a plurality of the votes present in person 
or represented by proxy and entitled to vote.


           MANAGEMENT AND THE BOARD OF DIRECTORS RECOMMEND A VOTE 
                        IN FAVOR OF EACH NAMED NOMINEE.



Nominees

        The names of the nominees and certain information about them are set 
forth below:

<TABLE>
<CAPTION>

                                      Principal Position             Director
              Name                     with the Company        Age     Since
- --------------------------------- -------------------------- ------- ---------
<S>                               <C>                        <C>     <C>
Sam Eletr, Ph.D. ..............  Chairman of the Board and      59      1992
                                    Chief Executive Officer
William K. Bowes, Jr.(1) .......  Director                       72      1994
Sydney Brenner, M.B., D. Phil. .  Director                       71      1993
James C. Kitch(1) ..............  Director                       51      1993
Kathleen D. La Porte(2) ........  Director                       37      1994
Craig C. Taylor(2) .............  Director                       48      1994
</TABLE>
- ---------
(1)  Member of the Audit Committee
(2)  Member of the Compensation Committee

        Sam Eletr has served as Chairman of the Board of the Company since 
February 1992 and resumed the position of Chief Executive Officer of the 
Company in November 1996, a position he held from February 1992 through 
January 1996.  In 1981, Dr. Eletr founded Applied Biosystems, Inc., a 
manufacturer of instruments and consumables for life science research and 
related applications, now a wholly-owned subsidiary of Perkin Elmer 
Corporation, and served as Chairman of the Board of Directors and in 
various executive positions at ABI from its inception until March 1987.  
Dr. Eletr acted as a consultant to ABI from September 1990 until July 
1992, during which time he undertook to assume the leadership of the 
Company.

        William K. Bowes, Jr. has served as a director of the Company since 
March 1994.  He has been a general partner of U.S. Venture Partners, a 
venture capital partnership, since 1981.  He currently serves as a 
director of Amgen, Inc., a biotechnology company, AMCC, an integrated 
circuit company, XOMA Corporation, a biotechnology company, and one U.S. 
Venture Partners' privately owned portfolio company. 

        Sydney Brenner has served as a director of the Company since October 
1993.  In July 1996, he was appointed the Director and President of The 
Molecular Sciences Institute, a non-profit research institute in Berkeley, 
California.  In September 1996 he retired from his position of Honorary 
Professor of Genetic Medicine, University of Cambridge Clinical School.  
From 1986 to his retirement in 1991, Dr. Brenner directed the Medical 
Research Council Unit of Molecular Genetics.  He was a member of the 
Scripps Research Institute in La Jolla, California until December 1994.

        James C. Kitch has served as a director of the Company since 
February 1993 and Secretary of Lynx from February 1992 to December 1997.  
He was a director of ABI, Lynx's predecessor, from August 1986 to February 
1993.  He is a partner at Cooley Godward LLP, a law firm which has 
provided legal services to the Company.

        Kathleen D. La Porte has served as a director of the Company since 
March 1994.  She is a general partner of the Sprout Group, the venture 
capital affiliate of Donaldson, Lufkin and Jenrette.  From 1987 to 1993, 
Ms. La Porte was a principal at Asset Management Company.  She currently 
serves as a director of Keravision, Inc., a medical device company, Gentle 
Dental Service Corporation, a healthcare service company, and several 
private companies.

        Craig C. Taylor has served as a director of the Company since March 
1994 and as Acting Chief Financial Officer from July 1994 to April 1997.  
He has been active in venture capital since 1977 when he joined Asset 
Management Company.  He is a general partner of AMC Partners 89 L.P., 
which serves as the general partner of Asset Management Associates 1989 
L.P., a private venture capital partnership.  He currently serves as a 
director of Metra BioSystems, Inc., a biotechnology company, 
Pharmacyclics, Inc., a biotechnology company, and several private 
companies.

Board Committees and Meetings

        During the calendar year ended December 31, 1998, the Board of 
Directors held five meetings.  The Board has an Audit Committee and a 
Compensation Committee.  The Board does not have a standing Nominating 
Committee.

        The Audit Committee meets with the Company's independent auditors at 
least annually to review the results of the annual audit and discuss the 
financial statements, recommends to the Board the independent auditors to 
be retained, and receives and considers the accountants' comments as to 
controls, adequacy of staff and management performance and procedures in 
connection with audit and financial controls.  The Audit Committee is 
composed of Messrs. Bowes and Kitch.  It met one time during such calendar 
year.

        The Compensation Committee reviews and recommends salaries and 
incentive compensation for officers and key employees.  The Compensation 
Committee also serves as the Stock Option Committee for the Company's 1992 
Stock Option Plan for the employees of the Company and in that capacity 
approves employee stock option grants.  The Compensation Committee is 
composed of two non-employee directors: Ms. La Porte and Mr. Taylor.  It 
met one time during such calendar year.

        During the calendar year ended December 31, 1998, each Board member 
attended 80% or more of the aggregate of the meetings of the Board and of 
the committees on which he or she served, held during the period for which 
he or she was a director or committee member, respectively.

                                PROPOSAL 2

            APPROVAL OF THE 1992 STOCK OPTION PLAN, AS AMENDED


        In July 1992, the Board of Directors of the Company (the "Board") 
adopted, and the stockholders subsequently approved, the Company's 1992 
Stock Option Plan (the "1992 Plan"). As a result of a series of 
amendments, there are currently 4,000,000 shares of the Company's Common 
Stock authorized for issuance under the 1992 Plan.  In May 1996, the Board 
adopted, and the stockholders subsequently approved, an amendment to the 
1992 Plan to extend the term of the 1992 Plan until March 2006.  At March 
1, 1999, options covering an aggregate of 3,149,163 shares, less canceled 
shares, of Common Stock had been granted under the 1992 Plan, and 
approximately 713,107 shares remained available for future grants.

        In March 1999, the Board approved an amendment to the 1992 Plan, 
subject to stockholder approval, to enhance the flexibility of the Board 
in granting stock options under the 1992 Plan.  The amendment increases 
the number of shares authorized for issuance under the 1992 Plan from a 
total of 4,000,000 shares to 4,200,000 shares.  The Board adopted this 
amendment to ensure that the Company can continue to grant stock options 
at levels determined appropriate by the Board.  During the last fiscal 
year, the Company granted options under the 1992 Plan (i) to current 
executive officers and directors to purchase 50,000 shares of Common Stock 
at an exercise price of $15.00 per share, and (ii) to all employees and 
consultants as a group (excluding executive officers) to purchase 357,500 
shares of Common Stock at exercise prices of $7.13 to $15.00 per share.

       In March 1999, the Board also amended the 1992 Plan, subject to 
stockholder approval, generally to include directors (including non-
employee directors) of the Company and its affiliates as eligible to 
participate in the 1992 Plan.  The amendment was required in order for the 
Company to grant nonstatutory stock options to non-employee directors 
under the 1992 Plan.  In March 1999, the Board also amended the 1992 Plan, 
subject to stockholder approval, to increase the limitation, required 
pursuant to Section 162(m) of the Internal Revenue Code of 1986, as 
amended (the "Code"), on the maximum number of shares covered by options 
granted to any employee under the 1992 Plan in a calendar year to 
1,000,000 (the "Section 162(m) Limitation").  Previously, the Section 
162(m) limitation was 500,000 shares.  Also, in March 1999, the Board 
amended the 1992 Plan generally to update provisions relating to change of 
control and to update language and terminology.

        Stockholders are requested in this Proposal 2 to approve the 1992 
Plan, as amended.  If the stockholders fail to approve this Proposal 2, 
options granted under the 1992 Plan after the Annual Meeting will not 
qualify as performance-based compensation and, in some circumstances, the 
Company may be denied a business expense deduction for compensation 
recognized in connection with the exercise of these stock options.  The 
affirmative vote of the holders of a majority of the shares present in 
person or represented by proxy and entitled to vote at the meeting will be 
required to approve the 1992 Plan, as amended.  Abstentions will be 
counted toward the tabulation of votes cast on proposals presented to the 
stockholders and will have the same effect as negative votes.  Broker non-
votes are counted towards a quorum, but are not counted for any purpose in 
determining whether this matter has been approved.


        MANAGEMENT AND THE BOARD OF DIRECTORS RECOMMEND A VOTE 
                        IN FAVOR OF PROPOSAL 2.


        The essential features of the 1992 Plan are outlined below:

General

        The 1992 Plan provides for the grant of both incentive and 
nonstatutory stock options.  Incentive stock options granted under the 
1992 Plan are intended to qualify as "incentive stock options" within 
the meaning of Section 422 of the Internal Revenue Code of 1986, as 
amended (the "Code").  Nonstatutory stock options granted under the 1992 
Plan are intended not to qualify as incentive stock options under the 
Code.  See "Federal Tax Information" for a discussion of the tax 
treatment of incentive and nonstatutory stock options.

Purpose

        The 1992 Plan was adopted to provide a means by which selected 
officers, employees of, and consultants to the Company and its affiliates 
could be given an opportunity to purchase stock in the Company, to assist 
in retaining the services of employees holding key positions, to secure 
and retain the services of persons capable of filling such positions and 
to provide incentives for such persons to exert maximum efforts for the 
success of the Company.  All of the Company's approximately 90 employees 
and consultants are currently eligible to participate in the 1992 Plan.  
Subject to Stockholder approval of this Proposal 2, all the Company's 
directors (including specifically all non-employee directors) will also be 
eligible to participate in the 1992 Plan.

Administration

        The 1992 Plan is administered by the Board.  Subject to the 
provisions of the 1992 Plan, the Board has the power to construe and 
interpret the 1992 Plan and, to determine the persons to whom and the 
dates on which options will be granted, the number of shares of common 
stock to be subject to each option, the time or times during the term of 
each option within which all or a portion of such option may be exercised, 
the exercise price, the type of consideration and other terms of the 
option.

        The 1992 Plan is administered by the Board unless and until the 
Board delegates administration to a committee composed of two or more 
Board members, all of the members of which committee may be non-employee 
directors (as such term is defined in Rule 16b-3 promulgated under the 
Securities Exchange Act of 1934, as amended (the "Exchange Act"), and/or 
outside directors (as such term is defined in the Treasury regulations 
promulgated under Section 162(m) of the Code).  If administration is 
delegated to a committee, such committee will have, in connection with the 
administration of the 1992 Plan, the powers possessed by the Board, 
subject, however, to such resolutions, not inconsistent with the 
provisions of the 1992 Plan, as may be adopted from time to time by the 
Board.  The Board or the committee may delegate to a committee of one or 
more members of the Board the authority to grant options to eligible 
persons who are not then subject to Section 16 of the Exchange Act and/or 
who are either (i) not then employees covered by Code Section 162(m) and 
are not expected to be covered by Section 162(m) at the time of 
recognition of income resulting from such option, or (ii) not persons with 
respect to whom the Company wishes to avoid the application of Section 
162(m).  The Board may abolish such committee at any time and revest in 
the Board the administration of the 1992 Plan.  The Board has delegated 
administration of the 1992 Plan to the Compensation Committee of the 
Board.  As used herein with respect to the 1992 Plan, the "Board" refers 
to the Compensation Committee as well as to the Board itself.

Eligibility

        Incentive stock options may be granted under the 1992 Plan only to 
selected key employees (including officers) of the Company and its 
affiliates.  Selected key employees (including officers) and consultants 
are currently eligible to receive nonstatutory stock options under the 
1992 Plan.  Subject to stockholder approval of this Proposal 2, all of the 
Company's directors (including specifically all non-employee directors) 
will also be eligible to receive nonstatutory stock options under the 1992 
Plan.

        No incentive stock option may be granted under the 1992 Plan to any 
person who, at the time of the grant, owns (or is deemed to own) stock 
possessing more than 10% of the total combined voting power of the Company 
or any affiliate of the Company, unless the option exercise price is at 
least 110% of the fair market value of the stock subject to the option on 
the date of grant, and the term of the option does not exceed five years 
from the date of grant.  For incentive stock options granted under the 
1992 Plan (and all such other plans of the Company and its affiliates), 
the aggregate fair market value, determined at the time of grant, of the 
shares of Common Stock with respect to which such options are exercisable 
for the first time by an optionholder during any calendar year (under all 
such plans of the Company and its affiliates) may not exceed $100,000.

        Subject to this stockholder approval of this Proposal 2, no employee 
may be granted options under the 1992 Plan covering more than 1,000,000 
shares of Common Stock during any calendar year.

Stock Subject to the 1992 Plan

        Subject to stockholder approval of this Proposal 2, an aggregate of 
4,200,000 shares of Common Stock are authorized for issuance under the 
1992 Plan.  If options granted under the 1992 Plan expire or otherwise 
terminate without being exercised, the shares of Common Stock not acquired 
pursuant to such options again become available for issuance under the 
1992 Plan.

Terms of Options

        The following is a description of the permissible terms of options 
under the 1992 Plan.  Individual option grants may be more restrictive as 
to any or all of the permissible terms described below.

        Exercise Price; Payment.  The exercise price of incentive stock 
options under the 1992 Plan may not be less than the fair market value of 
the Common Stock subject to the option on the date of the option grant, 
and in some cases (see "Eligibility" above), may not be less than 110% of 
such fair market value.  The exercise price of nonstatutory options under 
the 1992 Plan may not be less than 85% of the fair market value of the 
Common Stock subject to the option on the date of the option grant.  At 
March 1, 1999, the closing price of the Company's Common Stock as reported 
on The Nasdaq National Marketr was $11.00 per share.

        The exercise price of options granted under the 1992 Plan must be 
paid either: (a) in cash at the time the option is exercised; (b) at the 
discretion of the Board, by delivery of other Common Stock of the Company 
or pursuant to a deferred payment arrangement, or (c) in any other form of 
legal consideration acceptable to the Board.

        Option Exercise.  Options granted under the 1992 Plan may become 
exercisable ("vest") in cumulative increments as determined by the 
Board.  Shares covered by options granted in the future under the 1992 
Plan may be subject to different vesting terms.  Options granted to date 
under the 1992 Plan typically vest in cumulative increments over a period 
of five years during the optionholder's employment or service with the 
Company.  The Board has the power to accelerate the time during which an 
option may be exercised.  In addition, options granted under the 1992 Plan 
may permit exercise prior to vesting, but in such event the optionholder 
may be required to enter into an early exercise stock purchase agreement 
that allows the Company to repurchase shares not yet vested should the 
optionholder leave the employ of the Company before vesting.  To the 
extent provided by the terms of an option, an optionholder may satisfy any 
federal, state or local tax withholding obligation relating to the 
exercise of such option by a cash payment upon exercise, by authorizing 
the Company to withhold a portion of the stock otherwise issuable to the 
optionholder, by delivering already-owned stock of the Company or by a 
combination of these means.

        Term.  The maximum term of options under the 1992 Plan is 10 years, 
except that in certain cases (see "Eligibility") the maximum term is five 
years.  Options under the 1992 Plan terminate three months after the 
optionholder ceases to be in continuous service with the Company or any 
affiliate of the Company, unless (a) the termination of service is due to 
such person's permanent and total disability (as defined in the Code), in 
which case the option may, but need not, provide that it may be exercised 
at any time within 12 months of such termination; (b) the optionholder 
dies while in service with the Company or any affiliate of the Company, in 
which case the option may, but need not, provide that it may be exercised 
(to the extent the option was exercisable at the time of the 
optionholder's death) within 12 months of the optionholder's death by the 
person or persons to whom the rights to such option pass by will or by the 
laws of descent and distribution; or (c) the option by its terms 
specifically provides otherwise.  Individual options by their terms may 
provide for exercise within a longer period of time following termination 
of employment or the service relationship.  The option term may also be 
extended in the event that exercise of the option within these periods is 
prohibited for specified reasons.

Adjustment Provisions

If any change is made in the stock subject to the 1992 Plan or 
subject to any option without the receipt of consideration by the Company 
(through merger, consolidation, reorganization, recapitalization, 
reincorporation, stock dividend, dividend in property other than cash, 
stock split, liquidating dividend, combination of shares, exchange of 
shares, change in corporate structure or other transaction not involving 
the receipt of consideration by the Company), the 1992 Plan will be 
appropriately adjusted in the class(es) and maximum number of securities 
subject to the 1992 Plan pursuant to subsection 4(a) of the 1992 Plan and 
the maximum number of securities subject to award to any person pursuant 
to subsection 5(c) of the 1992 Plan, and outstanding options will be 
appropriately adjusted in the class(es) and number of securities and price 
per share of stock subject to such outstanding options.  Such adjustments 
shall be made by the Board, the determination of which shall be final, 
binding and conclusive.  (The conversion of any convertible securities of 
the Company shall not be treated as a transaction "without receipt of 
consideration" by the Company.)

Effect of Certain Corporate Events

        The 1992 Plan provides that, in the event of a specified type of 
merger or other corporate reorganization, to the extent permitted by law, 
any surviving corporation shall assume any options outstanding under the 
1992 Plan or substitute similar options for those outstanding under such 
plan, or such outstanding options will continue in full force and effect.  
In the event that any surviving corporation refuses to assume or continue 
options outstanding under the 1992 Plan, or to substitute similar options, 
then with respect to optionholders whose service has not terminated, the 
vesting and the time during which such options may be exercised shall be 
accelerated.  In such a case, an outstanding option will terminate if the 
optionholder does not exercise it before the change in control.

Duration, Amendment and Termination.

        The Board may suspend or terminate the 1992 Plan without stockholder 
approval or ratification at any time.  Unless sooner terminated, the 1992 
Plan will terminate on March 11, 2006.

        The Board may also amend the 1992 Plan at any time or from time to 
time.  However, no amendment will be effective unless approved by the 
stockholders of the Company within 12 months before or after its adoption 
by the Board to the extent stockholder approval is necessary to satisfy 
the requirements of Section 422 of the Code, Rule 16b-3 promulgated under 
the Exchange Act, or any Nasdaq or other securities exchange listing 
requirements.  The Board may in its sole discretion submit any other 
amendment to the 1992 Plan for stockholder approval.

Restrictions on Transfer

        Under the 1992 Plan, an incentive stock option may not be 
transferred by the optionholder otherwise than by will or by the laws of 
descent and distribution.  During the lifetime of an optionholder, an 
incentive stock option may be exercised only by the optionholder.  A 
nonstatutory stock option is transferable to the extent provided in the 
option agreement.  If the option agreement for a nonstatutory stock option 
does not provide for transferability, then the nonstatutory stock option 
is not transferable except by will or by the laws of descent and 
distribution and is exercisable during the lifetime of the optionholder 
only by the optionholder.  In addition, shares subject to repurchase by 
the Company under an early exercise stock purchase agreement may be 
subject to restrictions on transfer which the Board deems appropriate.

Federal Income Tax Information

        Long-term capital gains currently are generally subject to lower tax 
rates than ordinary income or short-term capital gains.  The maximum long-
term capital gains rate for federal income tax purposes is currently 20% 
while the maximum ordinary income rate and short-term capital gains rate 
is effectively 39.6%.  Slightly different rules may apply to optionholders 
who acquire stock subject to certain repurchase options or who are subject 
to Section 16(b) of the Exchange Act.

        Incentive Stock Options.  Incentive Stock options under the 1992 
Plan are intended to be eligible for the favorable federal income tax 
treatment accorded "incentive stock options" under the Code.

        There generally are no federal income tax consequences to the 
optionholder or the Company by reason of the grant or exercise of an 
incentive stock option.  However, the exercise of an incentive stock 
option may increase the optionholder's alternative minimum tax liability, 
if any.

        If an optionholder holds stock acquired through exercise of an 
incentive stock option for at least two years from the date on which the 
option is granted and at least one year from the date on which the shares 
are transferred to the optionholder upon exercise of the option, any gain 
or loss on a disposition of such stock will be a long-term capital gain or 
loss if the optionholder held the stock for more than one year.  
Generally, if the optionholder disposes of the stock before the expiration 
of either of these holding periods (a "disqualifying disposition"), at the 
time of disposition, the optionholder will realize taxable ordinary income 
equal to the lesser of (a) the excess of the stock's fair market value on 
the date of exercise over the exercise price, or (b) the optionholder's 
actual gain, if any, on the purchase and sale.  The optionholder's 
additional gain or any loss upon the disqualifying disposition will be a 
capital gain or loss which will be long-term or short-term depending on 
whether the stock was held for more than one year.  Slightly different 
rules may apply to optionholders who acquire stock subject to certain 
repurchase options or who are subject to Section 16(b) of the Exchange 
Act.

        To the extent the optionholder recognizes ordinary income by reason 
of a disqualifying disposition, the Company will generally be entitled 
(subject to the requirement of reasonableness and the satisfaction of a 
tax reporting obligation) to a corresponding business expense deduction in 
the tax year in which the a disqualifying disposition occurs.

        Nonstatutory Stock Options.  Nonstatutory stock options granted 
under the 1992 Plan generally have the following federal income tax 
consequences:

        There are no tax consequences to the optionholder or the Company by 
reason of the grant of a nonstatutory stock option.  Upon exercise of a 
nonstatutory stock option, the optionholder normally will recognize 
taxable ordinary income equal to the excess, if any, of the stock's fair 
market value on the date of exercise over the option exercise price.  
Generally, with respect to employees, the Company is required to withhold 
from regular wages or supplemental wage payments an amount based on the 
ordinary income recognized.  Subject to the requirement of reasonableness 
and the satisfaction of any tax reporting obligation, the Company will 
generally be entitled to a business expense deduction equal to the taxable 
ordinary income realized by the optionholder.  Upon disposition of the 
stock, the optionholder will recognize a capital gain or loss equal to the 
difference between the selling price and the sum of the amount paid for 
such stock plus any amount recognized as ordinary income upon exercise of 
the option.  Such gain or loss will be long-term or short-term depending 
on whether the stock was held for more than one year.  Slightly different 
rules may apply to optionholders who acquire stock subject to certain 
repurchase options or who are subject to Section 16(b) of the Exchange 
Act.

        Potential Limitation on Company Deductions. Section 162(m) of the 
Code denies a deduction to any publicly held corporation for compensation 
paid to certain employees in a taxable year to the extent that 
compensation exceeds $1,000,000 for a covered employee.  It is possible 
that compensation attributable to stock options, when combined with all 
other types of compensation received by a covered employee from the 
Company, may cause this limitation to be exceeded in any particular year.   

        Certain kinds of compensation, including qualified "performance-
based compensation," are disregarded for purposes of the deduction 
limitation.  In accordance with Treasury regulations issued under Section 
162(m), compensation attributable to stock options will qualify as 
performance-based compensation, provided that the option is granted by a 
compensation committee comprised solely of "outside directors" and 
either: (i) the option plan contains a per-employee limitation on the 
number of shares for which options may be granted during a specified 
period, the per-employee limitation is approved by the stockholders, and 
the exercise price of the option is no less than the fair market value of 
the stock on the date of grant; or (ii) the option is granted (or 
exercisable) only upon the achievement (as certified in writing by the 
compensation committee) of an objective performance goal established in 
writing by the compensation committee while the outcome is substantially 
uncertain, and the option is approved by stockholders.


                                PROPOSAL 3

             RATIFICATION OF SELECTION OF INDEPENDENT AUDITORS


        The Board of Directors has selected Ernst & Young LLP as the 
Company's independent auditors for the fiscal year ending December 31, 
1999 and has further directed that management submit the selection of 
independent auditors for ratification by the stockholders at the Annual 
Meeting.  Ernst & Young LLP has audited the Company's financial statements 
since its inception in 1992.  Representatives of Ernst & Young LLP are 
expected to be present at the Annual Meeting, will have an opportunity to 
make a statement if they so desire and will be available to respond to 
appropriate questions.

        Stockholder ratification of the selection of Ernst & Young LLP as 
the Company's independent auditors is not required by the Company's By-
laws or otherwise.  However, the Board is submitting the selection of 
Ernst & Young LLP to the stockholders for ratification as a matter of good 
corporate practice.  If the stockholders fail to ratify the selection, the 
Audit Committee and the Board will reconsider whether or not to retain 
that firm.  Even if the selection is ratified, the Audit Committee and the 
Board in their discretion may direct the appointment of different 
independent auditors at any time during the year if they determine that 
such a change would be in the best interests of the Company and its 
stockholders.

        The affirmative vote of the holders of a majority of the shares 
present in person or represented by proxy and entitled to vote at the 
Annual Meeting will be required to ratify the selection of Ernst & Young 
LLP.  Abstentions will be counted toward the tabulation of votes cast on 
proposals presented to stockholders and will have the same effect as 
negative votes.  Broker non-votes are counted towards a quorum, but are 
not counted for any purpose in determining whether this matter has been 
approved.


         MANAGEMENT AND THE BOARD OF DIRECTORS RECOMMEND A VOTE 
                         IN FAVOR OF PROPOSAL 3.



SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

        The following table sets forth certain information regarding 
beneficial ownership of the Company's Common Stock as of March 1, 1999, by 
(i) each stockholder who is known by the Company to own beneficially more 
than 5% of the Common Stock; (ii) each Named Executive Officer of the 
Company listed on the Summary Compensation Table; (iii) each director of 
the Company; and (iv) all directors and executive officers of the Company 
as a group. 

<TABLE>
<CAPTION>

                                                  Common Stock(1)
                                              ---------------------
Name and Address of Beneficial Owners           Number   Percent(2)
- --------------------------------------------  ---------- ----------
<S>                                           <C>        <C>
Entities affiliated with
  U.S. Venture Partners IV, L.P.(3)........     730,000        6.6%
  2180 Sand Hill Road, Suite 300
  Menlo Park, CA  94025

Entities affiliated with the
  Sprout Group(4)..........................     729,980        6.6%
  3000 Sand Hill Road, Suite 270
  Menlo Park, CA  94025

Cannon Street Fund Ltd.....................     565,000        5.1%
  c/o Meridian Venture Group
  R.R. Box 272
  Charlottesville, VA  22314

Asset Management Associates 1989 L.P.(5)...     360,000        3.2%

Sam Eletr, Ph.D.(6)........................     460,759        4.1%

Edward C. Albini(7)........................     100,000       **

William K. Bowes, Jr.(8)...................     747,720        6.7%
  U.S. Venture Partners IV, L.P.
  2180 Sand Hill Road, Suite 300
  Menlo Park, CA  94025

Sydney Brenner, M.D., D. Phil.(9)..........     309,057        2.8%

James C. Kitch(10).........................       9,787       **

Kathleen D. La Porte(4)....................     729,980        6.6%
  Sprout Group
  3000 Sand Hill Road
  Building 4, Suite 270
  Menlo Park, CA  94025

Stephen C. Macevicz, Ph.D(11)..............      99,651       **

Craig C. Taylor(12)........................     371,497        3.3%

All directors and officers.................   2,828,451       25.4%
  as a group (11 persons)(13)

</TABLE>
- ---------
**Less than one percent.


(1)   This table is based upon information supplied by officer, directors, 
      and principal stockholders and Schedules 13D and 13G filed with the 
      Securities and Exchange Commission.  Except as otherwise noted, and 
      subject to community property laws where applicable, the Company 
      believes that each person or entity named in the table has sole 
      voting and investment power with respect to all shares shown as 
      beneficially owned by him, her or it.

(2)   Percentage of beneficial ownership is based on 11,132,815 shares of 
      Common Stock outstanding as of March 1, 1999, except as otherwise 
      noted in the footnotes.  Beneficial ownership is determined in 
      accordance with the rules of the Securities and Exchange Commission 
      and generally includes voting or investment power with respect to 
      securities.  Shares of Common Stock subject to options currently 
      exercisable or exercisable within 60 days of March 1, 1999, are 
      deemed outstanding for computing the percentage of the person 
      holding such option but are not deemed outstanding for computing the 
      percentage of any other person.

(3)   Includes 730,000 shares of Common Stock held by entities affiliated 
      with U.S. Venture Partners IV, L.P. ("U.S.V.P. IV")  Mr. Bowes, a 
      director of the Company, is a general partner of Presidio Management 
      Group IV, the general partner of U.S.V.P. IV.  Mr. Bowes shares the 
      power to vote and control the disposition of shares held by U.S.V.P. 
      IV and therefore may be deemed to be the beneficial owner of such 
      shares.  Mr. Bowes disclaims beneficial ownership of such shares, 
      except to the extent of his pro-rata interest therein.

(4)   Includes 729,980 shares of Common Stock held by entities affiliated 
      with the Sprout Group.  Ms. La Porte, a director of the Company, is 
      a general partner of the Sprout Group, an entity affiliated with 
      Sprout Capital VI, Sprout Capital VII and DLJ Capital.  Ms. La Porte 
      shares the power to vote and control the disposition of shares held 
      by Sprout Capital VI, Sprout Capital VII and DLJ Capital and 
      therefore may be deemed to be the beneficial owner of such shares.  
      Ms. La Porte disclaims beneficial ownership of such shares, except 
      to the extent of her pro-rata interest therein.

(5)   Includes 360,000 shares of Common Stock held by Asset Management 
      Associates 1989 L.P. ("Asset 1989 L.P.").  Mr. Taylor, a director of 
      the Company, is a general partner of AMC Partners 89, which is the 
      general partner of Asset 1989 L.P.  Mr. Taylor shares the power to 
      vote and control the disposition of shares held by Asset 1989 L.P. 
      and therefore may be deemed to be the beneficial owner of such 
      shares.  Mr. Taylor disclaims beneficial ownership of such shares, 
      except to the extent of his pro-rata interest therein. 

(6)   Includes 217,500 shares of Common Stock issuable upon exercise of 
      Lynx stock options held by Dr. Eletr that are exercisable within 60 
      days.

(7)   Includes 50,000 shares of Common Stock issuable upon exercise of 
      Lynx stock options held by Mr. Ablini.

(8)   See Note 3 above.  Common Stock amount also includes 17,720 shares 
      held by Mr. Bowes.

(9)   Includes 49,057 shares of Common Stock issuable upon exercise of 
      Lynx stock options held by Dr. Brenner that are exercisable within 
      60 days.

(10)  Includes 2,287 shares of Common Stock and 7,500 shares of Common 
      Stock issuable upon the exercise of Lynx stock options held by Mr. 
      Kitch on behalf of GC&H Investments, an investment partnership of 
      which Mr. Kitch is a general partner.  Mr. Kitch shares the power to 
      vote and control the disposition of such shares and therefore may be 
      deemed to be the beneficial owner of such shares.  Mr. Kitch 
      disclaims beneficial ownership of such shares, except to the extent 
      of his pro-rata interest therein.

(11)  Includes 54,000 shares of Common Stock issuable upon exercise of 
      Lynx stock options held by Dr. Macevicz that are exercisable within 
      60 days.

(12)  See Note 5 above.  Includes 11,497 shares of Common Stock held by 
      Mr. Taylor.

(13)  Includes 1,839,980 shares of Common Stock held directors and by 
      entities affiliated with certain directors and 324,057 shares of 
      Common Stock issuable upon exercise of Lynx stock options held by 
      directors and officers that are exercisable within 60 days.  See 
      Notes 3 through 12 above.

Section 16(a) Beneficial Ownership Reporting Compliance

        Section 16(a) of the Securities Exchange Act of 1934, as amended, 
(the "Exchange Act") requires the Company's directors and executive 
officers, and persons who own more than 10% of a registered 
class of the Company's equity securities, to file with the SEC initial 
reports of ownership and reports of changes in ownership of Common Stock 
and other equity securities of the Company.  Officers, directors and 
greater than 10% stockholders are required by SEC regulation 
to furnish the Company with copies of all Section 16(a) forms they file.

        To the Company's knowledge, based solely on a review of the copies 
of such reports furnished to the Company and written representations that 
no other reports were required, during the fiscal year ended December 31, 
1998, all Section 16(a) filing requirements applicable to its officers, 
directors and greater than 10% beneficial owners were complied with.

Directors

        Directors are not compensated by the Company for service as directors.


                           EXECUTIVE COMPENSATION

Executive Officers

        The executive officers of the Company and certain information about 
them as of December 31, 1998 are listed below:

<TABLE>
<CAPTION>

             Name               Age             Company Positions
- ------------------------------ ------ -------------------------------------
<S>                            <C>    <C>


Sam Eletr, Ph.D .............     59  Chief Executive Officer and 
                                        Chairman of the Board
Edward C. Albini ............     41  Chief Financial Officer and Secretary
Stephen C. Macevicz, Ph.D. ..     49  Vice President, Intellectual Property
</TABLE>

        Sam Eletr has served as Chairman of the Board of the Company since 
February 1992 and resumed the position of Chief Executive Officer of the 
Company in November 1996, a position he held from February 1992 through 
January 1996.  In 1981, Dr. Eletr founded Applied Biosystems, Inc., a 
manufacturer of instruments and consumables for life science research and 
related applications, now a wholly-owned subsidiary of Perkin Elmer 
Corporation, and served as Chairman of the Board of Directors and in 
various executive positions at ABI from its inception until March 1987.  
Dr. Eletr acted as a consultant to ABI from September 1990 until July 
1992, during which time he undertook to assume the leadership of the 
Company.

        Edward C. Albini has served as Chief Financial Officer of the 
Company since April 1997.  He was elected Secretary of the Company in 
February 1998.  From January 1983 to April 1997, Mr. Albini served in 
various financial management positions with Genentech, Inc., a 
biotechnology company.  His most recent role at Genentech was as the 
Director of Financial Planning and Analysis.  Mr. Albini holds a BS degree 
in Accounting from Santa Clara University and an MBA degree from Walter A. 
Haas School of Business at the University of California at Berkeley.  Mr. 
Albini is also a certified public accountant.

        Stephen C. Macevicz joined the Company in September 1995 as Vice 
President, Intellectual Property.  He was Senior Patent Attorney and Chief 
Patent Counsel of ABI, from 1992 to August 1995 and from 1986 to 1992, 
Patent Counsel of DNAX Research Institute of Molecular and Cellular 
Biology, a research subsidiary of Schering-Plough Corporation.  He 
received his law degree from the University of California, Berkeley (Boalt 
Hall) in 1984 and his Ph.D. in Biophysics from the University of 
California, Berkeley in 1979.


Compensation Tables

        Summary Compensation Table. The following table sets forth certain 
compensation paid by the Company during the calendar years ended December 
31, 1998, 1997 and 1996, to its Chief Executive Officer and each of the 
other most highly compensated executive officers whose compensation 
exceeded $100,000 (the "Named Executive Officers"):

                           SUMMARY COMPENSATION TABLE

<TABLE>
<CAPTION>
                                                                   Other 
                                                     Long-Term     Annual
                                         Annual     Compensation  Compensa-
  Name and Principal Position    Year   Salary(1)    Options(#)    tion(2)
- ------------------------------- ------- ---------   ------------ -----------
<S>                             <C>     <C>         <C>          <C>
Sam Eletr, Ph.D. ..............   1998  $230,460           --        $ --
  Chief Executive Officer and     1997   196,131           --          --
  Chairman of the Board           1996   176,121         32,500        --

Edward C. Albini ..............   1998  $147,336         50,000        $750
  Chief Financial Officer         1997   100,244 (3)     50,000        --
                                  1996       --            --          --

Stephen C. Macevicz, Ph.D. ....   1998  $167,611           --          $750
  Vice President, Intellectual    1997   155,886           --           750
  Property                        1996   144,505           --           750

</TABLE>
- ---------
(1)  Includes amounts earned but deferred at the election of the Named
     Executive Officer pursuant to the Company's 401(k) Plan.
(2)  Contributions made by the Company to the Company's 401(k) Plan on
     behalf of such employee.
(3)  Mr. Albini joined the Company on April 17, 1997.

        Except as disclosed above, no compensation characterized as long-
term compensation, including restricted stock awards issued at a price 
below fair market value or long-term incentive plan payouts, were paid by 
the Company during the year ended December 31, 1998, to any of the Named 
Executive Officers.

Stock Option Grants and Exercises

        The following table sets forth, for each of the Named Executive 
Officers in the Summary Compensation Table, certain information regarding 
options granted during the year ended December 31, 1998.

                       Option Grants in Last Fiscal Year

<TABLE>
<CAPTION>
                                            Individual Grants     
                              ----------------------------------------------
                                             Percent                            Potential Realizable
                                             of Total                             Value at Assumed
                                             Options                              Annual Rates of
                               Number of     Granted    Exercise                    Stock Price
                               Securities       to       or Base                 Appreciation for
                               Underlying   Employees   Price per   Expir-        Option Term(3)
                                Options     in Fiscal    Share       ation    -----------------------
            Name               Granted(1)    Year(2)     ($/sh)      Date        5%($)      %10%($)
- ----------------------------- ------------  ----------  ---------  ---------  ----------- -----------
<S>                           <C>           <C>         <C>        <C>        <C>         <C>
Edward C. Albini ............      50,000       12.59%    $15.00   02/26/08      471,671   1,195,307

</TABLE>
- ---------

(1)  Officers of the Company were granted the right to exercise their
     options prior to vesting, subject to the Company's right of
     repurchase at the original issue price, which lapses ratably over
     five years.  Options granted generally vest over a five-year
     period.  The term of the options is ten years.

(2)  Based on an aggregate of 397,500 options granted to employees of
     and consultants to the Company during the year ended December 31,
     1998, including the Named Executive Officer.

(3)  The potential realizable value is calculated based on the term of
     the option at its time of grant (ten years).  It is calculated by
     assuming that the stock price of the date of grant appreciates at
     the indicated annual rate, compounded annually for the entire
     term of the option, and that the option is exercised and sold on
     the last day of the term for the appreciated stock price.

        The following table sets forth certain information concerning the 
number of options exercised by the Named Executive Officers during the 
year ended December 31, 1998, and the number of shares covered by both 
exercisable and unexercisable stock options held by the Named Executive 
Officers.  Also reported are values for "in-the-money" options that 
represent the positive spread between the respective exercise prices of 
outstanding options and the fair market value of the Company's Common 
Stock as of December 31, 1998 ($11.44 per share).

  Aggregated Option Exercises in the Year Ended December 31, 1998 and Option 
                                    Values

<TABLE>
<CAPTION>

                                                                          Value of Unexercised
                         Shares                Number of Unexercised      In-the-Money Options
                        Acquired    Value       Options at Year-End           at Year-End(1)
                           on      Realized  -------------------------  -------------------------
         Name           Exercise     (1)     Exercisable Unexercisable  Exercisable Unexercisable
- ----------------------- ---------  --------  ----------- -------------  ----------- -------------
<S>                     <C>        <C>       <C>         <C>            <C>         <C>
Sam Eletr .............     --       $ --       189,333        28,167   $1,774,297      $278,853
Edward C. Albini ......     --         --          --          50,000         --           --
Stephen C. Macevicz ...     --         --        26,000        28,000      285,252       311,657

</TABLE>
- ---------

(1)  Based on the fair market value of the Company's Common Stock at
     December 31, 1998 ($11.44), minus the exercise price of the
     option, multiplied by the number of shares underlying the options.



<PAGE>



















                  REPORT OF THE COMPENSATION COMMITTEE (1)

General

        The Company became a public reporting company in December l993, when 
the Company registered its Common Stock and Series A preferred stock under 
the Exchange Act, and the Compensation Committee was established in March 
l994.  Accordingly, the Compensation Committee made the primary 
compensation determinations for the Company's officers during the year 
ended December 31, 1998, including the establishment of base salaries, 
consideration of bonuses and stock option grants.  During 1998, the 
members of the Compensation Committee were Kathleen La Porte and Craig 
Taylor.  The Compensation Committee has provided the following with 
respect to the compensation of executive officers during the year ended 
December 31, 1998:

Compensation Philosophy

        The Company and its Compensation Committee believe that the 
compensation of all employees, including executive officers, must be 
sufficient to attract and retain highly qualified personnel and that the 
Company must align compensation with short-term and long-term business 
strategies and performance goals.  The current compensation philosophy is 
to emphasize stockholder value linked with incentives such as stock 
options over salary increases. The basic elements of executive officer 
compensation are as follows:

        Salary.  To insure that its compensation practices remain 
competitive, the Company compares its compensation of executives with that 
of executives of other companies of similar industry, size and geographic 
location.  Salary increases are generally granted on an annual basis and 
are based on both individual performance and the standard percentage of 
salary increases granted to other employees.

        Bonuses.  During 1998, the Compensation Committee did not consider 
bonuses when establishing executive compensation, focusing instead on base 
salary and long-term incentives as the primary compensation vehicles 
appropriate to the early stages of the Company's development.  As part of 
its general compensation philosophy, however, the Company believes that 
executive performance may be maximized via a system of annual incentive 
awards, and the Company may consider such awards in the future.

        Long-term Incentives.  The Company believes that equity ownership 
provides significant motivation to executive officers to maximize value 
for the Company's stockholders.  The Compensation Committee grants stock 
options to executive officers and other key employees based on a variety 
of factors, including the financial performance of the Company and 

- ----------
(1)  The material in this report is not "soliciting material," is not deemed
"filed" with the SEC, and is not to be incorporated by reference into any
filing of the Company under the 1933 Act or 1934 Act, whether made before or
after the date hereof and irrespective of any general incorporation language
contained in such filing.

<PAGE>
assessment of personal performance.  Through stock option grants, 
executives receive significant equity incentives to build long-term 
stockholder value.  The exercise price of options generally is 100% of the 
fair market value as quoted on The Nasdaq Stock Marketr on the last market 
trading day prior to the day of determination.  Employees receive value 
from these grants only if the Common Stock appreciates in the long term.

        Employment and Severance Agreements.  The Company does not have 
employment or severance agreements with any of its officers or employees.

Chief Executive Officer Compensation

        Dr. Eletr's compensation was established in accordance with the 
criteria described above and was determined by the Board primarily on the 
basis of the salary received by Dr. Eletr in 1997 and pursuant to 
discussions between the Board and Dr. Eletr, with particular consideration 
given to Dr. Eletr's equity ownership position in the Company. In 
establishing compensation, the Board was mindful of the near complete 
dependence on Dr. Eletr for the success and direction of the Company given 
its early stage of operation as an independent entity.  Because of his 
ownership position in the Company, the salary established by the Board may 
not reflect a salary that would otherwise be required to competitively 
compensate and retain Dr. Eletr and may not be indicative of future 
compensation.

Certain Tax Considerations

        Section 162(m) of the Code limits the Company to a deduction for 
federal income tax purposes of not more than $1 million of compensation 
paid to certain executive officers in a taxable year. Compensation above 
$1 million may be deducted if it is "performance-based compensation" 
within the meaning of the Code. The Board has not yet established a policy 
for determining which forms of incentive compensation awarded to executive 
officers shall be designed to qualify as performance based compensation.

        From the members of the Compensation Committee:

        Kathleen La Porte
        Craig Taylor










Stock Performance Graph

        The following graph compares the 12-month cumulative total 
stockholder return on the Common Stock of the Company to that of the S&P 
Biotechnology Index, The Nasdaq Stock Market(RM) and the Hambrecht & Quist 
Biotechnology Index.*

                          PERFORMANCE GRAPH

[The following  descriptive  data is supplied in accordance  with Rule 304(d)
 of Regulation S-T]

<TABLE>
<CAPTION>
                LYNX
           THERAPEUTICS,   NASDAQ STOCK     S & P      HAMBRECHT & QUIST
  Date          INC.       MARKET (U.S.) BIOTECHNOLOGY   BIOTECHNOLOGY
- ---------  --------------  ------------  ------------  ------------------
<S>        <C>             <C>           <C>           <C>
12/30/97        100            100           100              100 
  12/97         126             98           106               99 
  1/98          125            101            98               99 
  2/98          116            111           104              104 
  3/98           78            115           119              113 
  4/98           82            117           117              110 
  5/98           69            110           118              105 
  6/98           73            118           128              106 
  7/98          103            117           144              110 
  8/98           72             94           119               90 
  9/98           63            107           148              112 
  10/98          76            112           154              120 
  11/98         100            123           147              123 
  12/98          89            139           205              150 
</TABLE>


*  $100 Invested on 12/30/97 in stock or on 11/30/97
    in index - including reinvestment of dividends.
    Fiscal year ending December 31.




Compensation Committee Interlocks and Insider Participation

        As noted above, the Company's Compensation Committee was established 
in March 1994 by two non-employee directors, Ms. Kathleen La Porte and Mr. 
Craig Taylor.  There were no officers or employees of the Company who 
participated in deliberations of the Company's Compensation Committee 
concerning executive officer compensation during the year ended December 
31, 1998.

 Certain Relationships and Related Transactions

        In April 1997, the Company entered into a full-recourse loan 
agreement with Edward C. Albini, an officer of the Company.  A note 
receivable of $250,000 was issued under a stock purchase agreement for the 
purchase of 50,000 shares of Common Stock whereby all the shares issued 
under the agreement are pledged as collateral.  The outstanding principal 
amount is due and payable in full in April 2002, subject to an obligation 
to prepay under specified circumstances.  Interest is payable upon the 
expiration or termination of the note and accrues at the rate of 6.49% per 
annum.

        In October 1995, the Company entered into a full-recourse loan 
agreement with Karoly Nikolich, a former officer of the Company. A note 
receivable of $210,000 was issued under a stock purchase agreement for the 
purchase of 60,000 shares of Common Stock whereby all the shares issued 
under the agreement are pledged as collateral.  The note and all interest 
receivable was paid in full according to the terms of the agreement in 
April 1998.


        For legal services rendered during the calendar year ended December 
31, 1998, the Company paid approximately $239,000 to Cooley Godward LLP, 
the Company's counsel, of which Mr. Kitch, a director of the Company, is a 
partner.


                              OTHER MATTERS

        The Board of Directors knows of no other matters that will be 
presented for consideration at the Annual Meeting.  If any other matters 
are properly brought before the meeting, it is the intention of the 
persons named in the accompanying proxy to vote on such matters in 
accordance with their best judgment.

                                        By Order of the Board of Directors

                                          [SIGNATURE]

                                        Edward C. Albini
                                        Secretary


April 14, 1999


A copy of the Company's Annual Report to the Securities and Exchange 
Commission on Form 10-K for the period ended December 31, 1998, is 
available without charge upon written request to: Investor Relations, Lynx 
Therapeutics, Inc., 25861 Industrial Blvd., Hayward, California 94545.



<PAGE>













                         LYNX THERAPEUTICS, INC.
                 PROXY SOLICITED BY THE BOARD OF DIRECTORS
                  FOR THE ANNUAL MEETING OF STOCKHOLDERS 
                       TO BE HELD ON MAY 12, 1999

        The undersigned hereby appoints Sam Eletr and Edward C. Albini, and 
each of them, as attorneys and proxies of the undersigned, with full power 
of substitution, to vote all of the shares of stock of Lynx Therapeutics, 
Inc. (the "Company") which the undersigned may be entitled to vote at 
the Annual Meeting of Stockholders of Lynx Therapeutics, Inc. to be held 
at the Company's principal executive offices, 25861 Industrial Blvd., 
Hayward, CA  94545 at 9:00 a.m. (local time), and at any and all 
postponements, continuations and adjournments thereof, with all powers 
that the undersigned would possess if personally present, upon and in 
respect of the following matters and in accordance with the following 
instructions, with discretionary authority as to any and all other matters 
that may properly come before the meeting.

        UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED 
FOR ALL NOMINEES LISTED IN PROPOSAL 1 AND FOR PROPOSALS 2 AND 3 AS MORE 
SPECIFICALLY DESCRIBED IN THE PROXY STATEMENT.  IF SPECIFIC INSTRUCTIONS 
ARE INDICATED, THIS PROXY WILL BE VOTED IN ACCORDANCE THEREWITH.


SEE REVERSE                                                    SEE REVERSE
   SIDE         CONTINUED AND TO BE SIGNED ON REVERSE SIDE         SIDE


[X] Please mark votes
    as in this example.

    THE BOARD OF DIRECTORS RECOMMENDS A VOTE FOR THE NOMINEES FOR
    DIRECTORS LISTED BELOW AND A VOTE FOR PROPOSAL 2 AND FOR PROPOSAL 3.

    1.   To elect directors to hold office until the next Annual
         Meeting of Stockholders and until their successors are
         elected.

          NOMINEES:  Sam Eletr, William K. Bowes, Jr., Sydney Brenner,
          James C. Kitch, Kathleen D. La Porte, Craig C. Taylor

        FOR ALL NOMINEES [ ]        [ ] WITHHELD FROM ALL NOMINEES

[ ] _____________________________________      MARK HERE IF YOU PLAN
    For all nominess except as noted above        TO ATTEND THE     [ ]
                                                    MEETING


    2.   To approve the Company's 1992 Stock Option Plan, as amended,
         to increase the aggregate number of shares of common stock
         authorized for issuance under such plan by 200,000 shares
         and to amend certain eligibility and change of control
         provisions of such plan.

                 FOR           AGAINST           ABSTAIN
                 [ ]             [ ]               [ ]


    3.   To ratify the selection of Ernst & Young LLP as independent
         auditors of the Company for its fiscal year ending December
         31, 1999.

                 FOR           AGAINST           ABSTAIN
                 [ ]             [ ]               [ ]


    4.   To transact such other business as may properly come before
         the meeting or any adjournment or postponement thereof.


                                              MARK HERE FOR ADDRESS [ ]
                                              CHANGE AND NOTE AT LEFT 


    Please sign exactly as your name(s) appear(s) hereon.  All
    holders must sign.  When signing in a fiduciary capacity,
    please indicate full title as such.  If a corporation or
    partnership, please sign in full corporate or partnership
    name by authorized person.


    Signature:_____________  Date: ____  Signature:_____________  Date: ____









<PAGE>




















                         LYNX THERAPEUTICS, INC.
                         1992 STOCK OPTION PLAN

                          Adopted July 1, 1992
                        Amended February 26, 1998
                  Approved By Stockholders May 18, 1998
                          Amended March 16, 1999
              Approved by the Stockholders _____________, 1999

1. Purposes.

     (a) Eligible Option Recipients.  The persons eligible to receive 
Options are the Employees, Directors and Consultants of the Company and 
its Affiliates.

     (b) Available Options.  The purpose of the Plan is to provide a 
means by which eligible recipients of Options may be given an opportunity 
to benefit from increases in value of the Common Stock through the 
granting of the following Options:  (i) Incentive Stock Options, and (ii) 
Nonstatutory Stock Options.

     (c) General Purpose.  The Company, by means of the Plan, seeks to 
retain the services of the group of persons eligible to receive Options, 
to secure and retain the services of new members of this group and to 
provide incentives for such persons to exert maximum efforts for the 
success of the Company and its Affiliates.

2. Definitions.

     (a) "Affiliate" means any parent corporation or subsidiary 
corporation of the Company, whether now or hereafter existing, as those 
terms are defined in Sections 424(e) and (f), respectively, of the Code.

     (b) "Board" means the Board of Directors of the Company.

     (c) "Code" means the Internal Revenue Code of 1986, as amended.

     (d) "Committee" means a Committee appointed by the Board in 
accordance with subsection 3(c).

     (e) "Common Stock" means the common stock of the Company.

     (f) "Company" means Lynx Therapeutics, Inc., a Delaware corporation.

     (g) "Consultant" means any person, including an advisor, (1) 
engaged by the Company or an Affiliate to render consulting or advisory 
services and who is compensated for such services or (2) who is a member 
of the Board of Directors of an Affiliate.  However, the term 
"Consultant" shall not include either Directors of the Company who are 
not compensated by the Company for their services as Directors or 
Directors of the Company who are merely paid a director's fee by the 
Company for their services as Directors.

     (h) "Continuous Service" means that the Optionholder's service 
with the Company or an Affiliate, whether as an Employee, Director or 
Consultant, is not interrupted or terminated.  The Optionholder's 
Continuous Service shall not be deemed to have terminated merely because 
of a change in the capacity in which the Optionholder renders service to 
the Company or an Affiliate as an Employee, Consultant or Director or a 
change in the entity for which the Optionholder renders such service, 
provided that there is no interruption or termination of the 
Optionholder's Continuous Service.  For example, a change in status from 
an Employee of the Company to a Consultant of an Affiliate or a Director 
of the Company will not constitute an interruption of Continuous Service.  
The Board or the chief executive officer of the Company, in that party's 
sole discretion, may determine whether Continuous Service shall be 
considered interrupted in the case of any leave of absence approved by 
that party, including sick leave, military leave or any other personal 
leave.

     (i) "Covered Employee" means the chief executive officer and the 
four (4) other highest compensated officers of the Company for whom total 
compensation is required to be reported to stockholders under the Exchange 
Act, as determined for purposes of Section 162(m) of the Code.

     (j) "Director" means a member of the Board of Directors of the Company.

     (k) "Disability" means the permanent and total disability of a 
person within the meaning of Section 22(e)(3) of the Code.

     (l) "Employee" means any person employed by the Company or an 
Affiliate.  Mere service as a Director or payment of a director's fee by 
the Company or an Affiliate shall not be sufficient to constitute 
"employment" by the Company or an Affiliate.

     (m) "Exchange Act" means the Securities Exchange Act of 1934, as amended.

     (n) "Fair Market Value" means, as of any date, the value of the 
Common Stock determined as follows:

          (i) If the Common Stock is listed on any established stock 
exchange or traded on the Nasdaq National Market or the Nasdaq SmallCap 
Market, the Fair Market Value of a share of Common Stock shall be the 
closing sales price for such stock (or the closing bid, if no sales were 
reported) as quoted on such exchange or market (or the exchange or market 
with the greatest volume of trading in the Common Stock) on the last 
market trading day prior to the day of determination, as reported in The 
Wall Street Journal or such other source as the Board deems reliable.

          (ii) In the absence of such markets for the Common Stock, the 
Fair Market Value shall be determined in good faith by the Board.

     (o) "Incentive Stock Option" means an Option intended to qualify 
as an incentive stock option within the meaning of Section 422 of the Code 
and the regulations promulgated thereunder.

     (p) "Non-Employee Director" means a Director of the Company who 
either (i) is not a current Employee or Officer of the Company or its 
parent or a subsidiary, does not receive compensation (directly or 
indirectly) from the Company or its parent or a subsidiary for services 
rendered as a consultant or in any capacity other than as a Director 
(except for an amount as to which disclosure would not be required under 
Item 404(a) of Regulation S-K promulgated pursuant to the Securities Act 
("Regulation S-K")), does not possess an interest in any other 
transaction as to which disclosure would be required under Item 404(a) of 
Regulation S-K and is not engaged in a business relationship as to which 
disclosure would be required under Item 404(b) of Regulation S-K; or (ii) 
is otherwise considered a "non-employee director" for purposes of Rule 
16b-3.

     (q) "Nonstatutory Stock Option" means an Option not intended to 
qualify as an Incentive Stock Option.

     (r) "Officer" means a person who is an officer of the Company 
within the meaning of Section 16 of the Exchange Act and the rules and 
regulations promulgated thereunder.

     (s) "Option" means an Incentive Stock Option or a Nonstatutory 
Stock Option granted pursuant to the Plan.

     (t) "Option Agreement" means a written agreement between the 
Company and an Optionholder evidencing the terms and conditions of an 
individual Option grant.  Each Option Agreement shall be subject to the 
terms and conditions of the Plan.

     (u) "Optionholder" means a person to whom an Option is granted 
pursuant to the Plan or, if applicable, such other person who holds an 
outstanding Option.

     (v) "Outside Director" means a Director of the Company who 
either (i) is not a current employee of the Company or an "affiliated 
corporation" (within the meaning of Treasury Regulations promulgated 
under Section 162(m) of the Code), is not a former employee of the Company 
or an "affiliated corporation" receiving compensation for prior services 
(other than benefits under a tax qualified pension plan), was not an 
officer of the Company or an "affiliated corporation" at any time and is 
not currently receiving direct or indirect remuneration from the Company 
or an "affiliated corporation" for services in any capacity other than 
as a Director or (ii) is otherwise considered an "outside director" for 
purposes of Section 162(m) of the Code.

     (w) "Plan" means this Lynx Therapeutics, Inc. 1992 Stock Option Plan.

     (x) "Rule 16b-3" means Rule 16b-3 promulgated under the Exchange 
Act or any successor to Rule 16b-3, as in effect from time to time.

     (y) "Securities Act" means the Securities Act of 1933, as amended.

     (z) "Ten Percent Stockholder" means a person who owns (or is 
deemed to own pursuant to Section 424(d) of the Code) stock possessing 
more than ten percent (10%) of the total combined voting power of all 
classes of stock of the Company or of any of its Affiliates.

3. Administration.

     (a) Administration by Board.  The Board will administer the Plan 
unless and until the Board delegates administration to a Committee, as 
provided in subsection 3(c).

     (b) Powers of Board.  The board shall have the power, subject to, 
and within the limitations of, the express provisions of the Plan:

          (i) To determine from time to time which of the persons 
eligible under the Plan shall be granted Options; when and how each Option 
shall be granted; what type or combination of types of Option shall be 
granted; the provisions of each Option granted (which need not be 
identical), including the time or times when a person shall be permitted 
to receive stock pursuant to an Option; and the number of shares with 
respect to which an Option shall be granted to each such person.

          (ii) To construe and interpret the Plan and Options granted 
under it, and to establish, amend and revoke rules and regulations for its 
administration.  The Board, in the exercise of this power, may correct any 
defect, omission or inconsistency in the Plan or in any Option Agreement, 
in a manner and to the extent it shall deem necessary or expedient to make 
the Plan fully effective.

          (iii) To amend the Plan or an Option as provided in Section 11.

          (iv) Generally, to exercise such powers and to perform such 
acts as the Board deems necessary or expedient to promote the best 
interests of the Company which are not in conflict with the provisions of 
the Plan.

     (c) Delegation to Committee.

          (i) General.  The Board may delegate administration of the 
Plan to a Committee or Committees of one or more members of the Board, and 
the term "Committee" shall apply to any person or persons to whom such 
authority has been delegated.  If administration is delegated to a 
Committee, the Committee shall have, in connection with the administration 
of the Plan, the powers theretofore possessed by the Board, including the 
power to delegate to a subcommittee any of the administrative powers the 
Committee is authorized to exercise (and references in this Plan to the 
Board shall thereafter be to the Committee or subcommittee), subject, 
however, to such resolutions, not inconsistent with the provisions of the 
Plan, as may be adopted from time to time by the Board.  The Board may 
abolish the Committee at any time and revest in the Board the 
administration of the Plan.

          (ii) Committee Composition when Common Stock is Publicly 
Traded.  At such time as the Common Stock is publicly traded, in the 
discretion of the Board, a Committee may consist solely of two or more 
Outside Directors, in accordance with Section 162(m) of the Code, and/or 
solely of two or more Non-Employee Directors, in accordance with Rule 16b-3.
Within the scope of such authority, the Board or the Committee may (i) 
delegate to a committee of one or more members of the Board who are not 
Outside Directors, the authority to grant Options to eligible persons who 
are either (a) not then Covered Employees and are not expected to be 
Covered Employees at the time of recognition of income resulting from such 
Option or (b) not persons with respect to whom the Company wishes to 
comply with Section 162(m) of the Code and/or (ii) delegate to a committee 
of one or more members of the Board who are not Non-Employee Directors the 
authority to grant Options to eligible persons who are not then subject to 
Section 16 of the Exchange Act.

4. Shares Subject to the Plan.

     (a) Share Reserve.  Subject to the provisions of Section 10 
relating to adjustments upon changes in stock, the stock that may be 
issued pursuant to Options shall not exceed in the aggregate four million 
two hundred thousand (4,200,000) shares of Common Stock less any shares of 
Common Stock remaining outstanding which were originally issued to 
Employees, Officers or Directors of, or Consultants to, the Company 
pursuant to stock purchase agreements or similar compensatory arrangements 
approved by the Board.

     (b) Reversion of Shares to the Share Reserve.  If any Option shall 
for any reason expire or otherwise terminate, in whole or in part, without 
having been exercised in full, the stock not acquired under such Option 
shall revert to and again become available for issuance under the Plan.  
If any Common Stock acquired pursuant to the exercise of an Option shall 
for any reason be repurchased by the Company under an unvested share 
repurchase option provided under the Plan, the stock repurchased by the 
Company under such repurchase option shall not revert to and again become 
available for issuance under the Plan.

     (c) Source of Shares.  The stock subject to the Plan may be 
unissued shares or reacquired shares, bought on the market or otherwise.

5. Eligibility.

     (a) Eligibility for Specific Options.  Incentive Stock Options may 
be granted only to Employees. Nonstatutory Stock Options may be granted to 
Employees, Directors and Consultants.

     (b) Ten Percent Stockholders.  No Ten Percent Stockholder shall be 
eligible for the grant of an Incentive Stock Option unless the exercise 
price of such Option is at least one hundred ten percent (110%) of the 
Fair Market Value of the Common Stock at the date of grant and the Option 
is not exercisable after the expiration of five (5) years from the date of 
grant.

     (c) Section 162(m) Limitation.  Subject to the provisions of 
Section 10 relating to adjustments upon changes in stock, no employee 
shall be eligible to be granted Options covering more than One Million 
(1,000,000) shares of the Common Stock during any calendar year.

     (d) Consultants.  

          (i) A Consultant shall not be eligible for the grant of an 
Option if, at the time of grant, a Form S-8 Registration Statement under 
the Securities Act ("Form S-8") is not available to register either the 
offer or the sale of the Company's securities to such Consultant because 
of the nature of the services that the Consultant is providing to the 
Company, or because the Consultant is not a natural person, or as 
otherwise provided by the rules governing the use of Form S-8, unless the 
Company determines both (i) that such grant (A) shall be registered in 
another manner under the Securities Act (e.g., on a Form S-3 Registration 
Statement) or (B) does not require registration under the Securities Act 
in order to comply with the requirements of the Securities Act, if 
applicable, and (ii) that such grant complies with the securities laws of 
all other relevant jurisdictions.

          (ii) As of April 7, 1999 Form S-8 generally is available to 
consultants and advisors only if (i) they are natural persons; (ii) they 
provide bona fide services to the issuer, its parents, its majority-owned 
subsidiaries or majority-owned subsidiaries of the issuer's parent; and 
(iii) the services are not in connection with the offer or sale of 
securities in a capital-raising transaction, and do not directly or 
indirectly promote or maintain a market for the issuer's securities.

6. Option Provisions.

     Each Option shall be in such form and shall contain such terms and 
conditions as the Board shall deem appropriate.  All Options shall be 
separately designated Incentive Stock Options or Nonstatutory Stock 
Options at the time of grant, and a separate certificate or certificates 
will be issued for shares purchased on exercise of each type of Option.  
The provisions of separate Options need not be identical, but each Option 
shall include (through incorporation of provisions hereof by reference in 
the Option or otherwise) the substance of each of the following 
provisions:

     (a) Term.  Subject to the provisions of subsection 5(b) regarding 
Ten Percent Stockholders, no Incentive Stock Option shall be exercisable 
after the expiration of ten (10) years from the date it was granted.

     (b) Exercise Price of an Incentive Stock Option.  Subject to the 
provisions of subsection 5(b) regarding Ten Percent Stockholders, the 
exercise price of each Incentive Stock Option shall be not less than one 
hundred percent (100%) of the Fair Market Value of the stock subject to 
the Option on the date the Option is granted.  Notwithstanding the 
foregoing, an Incentive Stock Option may be granted with an exercise price 
lower than that set forth in the preceding sentence if such Option is 
granted pursuant to an assumption or substitution for another option in a 
manner satisfying the provisions of Section 424(a) of the Code.

     (c) Exercise Price of a Nonstatutory Stock Option.  The exercise 
price of each Nonstatutory Stock Option shall be not less than eighty-five 
percent (85%) of the Fair Market Value of the stock subject to the Option 
on the date the Option is granted.  Notwithstanding the foregoing, a 
Nonstatutory Stock Option may be granted with an exercise price lower than 
that set forth in the preceding sentence if such Option is granted 
pursuant to an assumption or substitution for another option in a manner 
satisfying the provisions of Section 424(a) of the Code.

     (d) Consideration.  The purchase price of stock acquired pursuant 
to an Option shall be paid, to the extent permitted by applicable statutes 
and regulations, either (i) in cash at the time the Option is exercised or 
(ii) at the discretion of the Board at the time of the grant of the Option 
(or subsequently in the case of a Nonstatutory Stock Option) by delivery 
to the Company of other Common Stock, according to a deferred payment or 
other arrangement (which may include, without limiting the generality of 
the foregoing, the use of other Common Stock) with the Optionholder or in 
any other form of legal consideration that may be acceptable to the Board; 
provided, however, that at any time that the Company is incorporated in 
Delaware, payment of the Common Stock's "par value," as defined in the 
Delaware General Corporation Law, shall not be made by deferred payment.

     In the case of any deferred payment arrangement, interest shall be 
compounded at least annually and shall be charged at the minimum rate of 
interest necessary to avoid the treatment as interest, under any 
applicable provisions of the Code, of any amounts other than amounts 
stated to be interest under the deferred payment arrangement.  

     (e) Transferability of an Incentive Stock Option.  An Incentive 
Stock Option shall not be transferable except by will or by the laws of 
descent and distribution and shall be exercisable during the lifetime of 
the Optionholder only by the Optionholder.  Notwithstanding the foregoing 
provisions of this subsection 6(e), the Optionholder may, by delivering 
written notice to the Company, in a form satisfactory to the Company, 
designate a third party who, in the event of the death of the 
Optionholder, shall thereafter be entitled to exercise the Option.

     (f) Transferability of a Nonstatutory Stock Option.  A
Nonstatutory Stock Option shall be transferable to the extent provided in 
the Option Agreement.  If the Nonstatutory Stock Option does not provide 
for transferability, then the Nonstatutory Stock Option shall not be 
transferable except by will or by the laws of descent and distribution and 
shall be exercisable during the lifetime of the Optionholder only by the 
Optionholder.  Notwithstanding the foregoing provisions of this subsection 
6(f), the Optionholder may, by delivering written notice to the Company, 
in a form satisfactory to the Company, designate a third party who, in the 
event of the death of the Optionholder, shall thereafter be entitled to 
exercise the Option.

     (g) Vesting Generally.  The total number of shares of Common Stock 
subject to an Option may, but need not, vest and therefore become 
exercisable in periodic installments which may, but need not, be equal.  
The Option may be subject to such other terms and conditions on the time 
or times when it may be exercised (which may be based on performance or 
other criteria) as the Board may deem appropriate.  The vesting provisions 
of individual Options may vary.  The provisions of this subsection 6(g) 
are subject to any Option provisions governing the minimum number of 
shares as to which an Option may be exercised.

     (h) Termination of Continuous Service.  In the event an 
Optionholder's Continuous Service terminates (other than upon the 
Optionholder's death or Disability), the Optionholder may exercise his or 
her Option (to the extent that the Optionholder was entitled to exercise 
it as of the date of termination) but only within such period of time 
ending on the earlier of (i) the date three (3) months following the 
termination of the Optionholder's Continuous Service (or such longer or 
shorter period specified in the Option Agreement), or (ii) the expiration 
of the term of the Option as set forth in the Option Agreement.  If, after 
termination, the Optionholder does not exercise his or her Option within 
the time specified in the Option Agreement, the Option shall terminate.

     (i) Extension of Termination Date.  An Optionholder's Option 
Agreement may also provide that if the exercise of the Option following 
the termination of the Optionholder's Continuous Service (other than upon 
the Optionholder's death or Disability) would be prohibited at any time 
solely because the issuance of shares would violate the registration 
requirements under the Securities Act, then the Option shall terminate on 
the earlier of (i) the expiration of the term of the Option set forth in 
subsection 6(a) or (ii) the expiration of a period of three (3) months 
after the termination of the Optionholder's Continuous Service during 
which the exercise of the Option would not be in violation of such 
registration requirements.

     (j) Disability of Optionholder.  In the event an Optionholder's 
Continuous Service terminates as a result of the Optionholder's 
Disability, the Optionholder may exercise his or her Option (to the extent 
that the Optionholder was entitled to exercise it as of the date of 
termination), but only within such period of time ending on the earlier of 
(i) the date twelve (12) months following such termination (or such longer 
or shorter period specified in the Option Agreement) or (ii) the 
expiration of the term of the Option as set forth in the Option Agreement.  
If, after termination, the Optionholder does not exercise his or her 
Option within the time specified herein, the Option shall terminate.

     (k) Death of Optionholder.  In the event (i) an Optionholder's 
Continuous Service terminates as a result of the Optionholder's death or 
(ii) the Optionholder dies within the period (if any) specified in the 
Option Agreement after the termination of the Optionholder's Continuous 
Service for a reason other than death, then the Option may be exercised 
(to the extent the Optionholder was entitled to exercise the Option as of 
the date of death) by the Optionholder's estate, by a person who acquired 
the right to exercise the Option by bequest or inheritance or by a person 
designated to exercise the option upon the Optionholder's death pursuant 
to subsection 6(e) or 6(f), but only within the period ending on the 
earlier of (1) the date twelve (12) months following the date of death (or 
such longer or shorter period specified in the Option Agreement) or (2) 
the expiration of the term of such Option as set forth in the Option 
Agreement.  If, after death, the Option is not exercised within the time 
specified herein, the Option shall terminate.

     (l) Early Exercise.  The Option may, but need not, include a 
provision whereby the Optionholder may elect at any time before the 
Optionholder's Continuous Service terminates to exercise the Option as to 
any part or all of the shares subject to the Option prior to the full 
vesting of the Option.  Any unvested shares so purchased may be subject to 
an unvested share repurchase option in favor of the Company or to any 
other restriction the Board determines to be appropriate.

7. Covenants of the Company.

     (a) Availability of Shares.  During the terms of the Options, the 
Company shall keep available at all times the number of shares of Common 
Stock required to satisfy such Options.

     (b) Securities Law Compliance.  The Company shall seek to obtain 
from each regulatory commission or agency having jurisdiction over the 
Plan such authority as may be required to grant Options and to issue and 
sell shares of Common Stock upon exercise of the Options; provided, 
however, that this undertaking shall not require the Company to register 
under the Securities Act the Plan, any Option or any stock issued or 
issuable pursuant to any such Option.  If, after reasonable efforts, the 
Company is unable to obtain from any such regulatory commission or agency 
the authority which counsel for the Company deems necessary for the lawful 
issuance and sale of stock under the Plan, the Company shall be relieved 
from any liability for failure to issue and sell stock upon exercise of 
such Options unless and until such authority is obtained.

8. Use of Proceeds from Stock.

     Proceeds from the sale of stock pursuant to Options shall constitute 
general funds of the Company.

9. Miscellaneous.

     (a) Acceleration of Exercisability and Vesting.  The Board shall 
have the power to accelerate the time at which an Option may first be 
exercised or the time during which an Option or any part thereof will vest 
in accordance with the Plan, notwithstanding the provisions in the Option 
stating the time at which it may first be exercised or the time during 
which it will vest.

     (b) Stockholder Rights.  No Optionholder shall be deemed to be the 
holder of, or to have any of the rights of a holder with respect to, any 
shares subject to such Option unless and until such Optionholder has 
satisfied all requirements for exercise of the Option pursuant to its 
terms.

     (c) No Employment or other Service Rights.  Nothing in the Plan or 
any instrument executed or Option granted pursuant thereto shall confer 
upon any Optionholder or other holder of Options any right to continue to 
serve the Company or an Affiliate in the capacity in effect at the time 
the Option was granted or shall affect the right of the Company or an 
Affiliate to terminate (i) the employment of an Employee with or without 
notice and with or without cause, (ii) the service of a Consultant 
pursuant to the terms of such Consultant's agreement with the Company or 
an Affiliate or (iii) the service of a Director pursuant to the Bylaws of 
the Company or an Affiliate, and any applicable provisions of the 
corporate law of the state in which the Company or the Affiliate is 
incorporated, as the case may be.

     (d) Incentive Stock Option $100,000 Limitation.  To the extent 
that the aggregate Fair Market Value (determined at the time of grant) of 
stock with respect to which Incentive Stock Options are exercisable for 
the first time by any Optionholder during any calendar year (under all 
plans of the Company and its Affiliates) exceeds one hundred thousand 
dollars ($100,000), the Options or portions thereof which exceed such 
limit (according to the order in which they were granted) shall be treated 
as Nonstatutory Stock Options.

     (e) Investment Assurances.  The Company may require an 
Optionholder, as a condition of exercising or acquiring stock under any 
Option, (i) to give written assurances satisfactory to the Company as to 
the Optionholder's knowledge and experience in financial and business 
matters and/or to employ a purchaser representative reasonably 
satisfactory to the Company who is knowledgeable and experienced in 
financial and business matters and that he or she is capable of 
evaluating, alone or together with the purchaser representative, the 
merits and risks of exercising the Option; and (ii) to give written 
assurances satisfactory to the Company stating that the Optionholder is 
acquiring the stock subject to the Option for the Optionholder's own 
account and not with any present intention of selling or otherwise 
distributing the stock.  The foregoing requirements, and any assurances 
given pursuant to such requirements, shall be inoperative if (iii) the 
issuance of the shares upon the exercise or acquisition of stock under the 
Option has been registered under a then currently effective registration 
statement under the Securities Act or (iv) as to any particular 
requirement, a determination is made by counsel for the Company that such 
requirement need not be met in the circumstances under the then applicable 
securities laws.  The Company may, upon advice of counsel to the Company, 
place legends on stock certificates issued under the Plan as such counsel 
deems necessary or appropriate in order to comply with applicable 
securities laws, including, but not limited to, legends restricting the 
transfer of the stock.

     (f) Withholding Obligations.  To the extent provided by the terms 
of an Option Agreement, the Optionholder may satisfy any federal, state or 
local tax withholding obligation relating to the exercise or acquisition 
of stock under an Option by any of the following means (in addition to the 
Company's right to withhold from any compensation paid to the Optionholder 
by the Company) or by a combination of such means:  (i) tendering a cash 
payment; (ii) authorizing the Company to withhold shares from the shares 
of the Common Stock otherwise issuable to the Optionholder as a result of 
the exercise or acquisition of stock under the Option; or (iii) delivering 
to the Company owned and unencumbered shares of the Common Stock.

10. Adjustments upon Changes in Stock.

     (a) Capitalization Adjustments.  If any change is made in the 
stock subject to the Plan, or subject to any Option, without the receipt 
of consideration by the Company (through merger, consolidation, 
reorganization, recapitalization, reincorporation, stock dividend, 
dividend in property other than cash, stock split, liquidating dividend, 
combination of shares, exchange of shares, change in corporate structure 
or other transaction not involving the receipt of consideration by the 
Company), the Plan will be appropriately adjusted in the class(es) and 
maximum number of securities subject to the Plan pursuant to subsection 
4(a) and the maximum number of securities subject to award to any person 
pursuant to subsection 5(c), and the outstanding Options will be 
appropriately adjusted in the class(es) and number of securities and price 
per share of stock subject to such outstanding Options.  Such adjustments 
shall be made by the Board, the determination of which shall be final, 
binding and conclusive.  (The conversion of any convertible securities of 
the Company shall not be treated as a transaction "without receipt of 
consideration" by the Company.)

     (b) Change in Control--Dissolution or Liquidation.  In the event 
of a dissolution or liquidation of the Company, then such Options shall be 
terminated if not exercised (if applicable) prior to such event.

     (c) Change in Control--Asset Sale, Merger, Consolidation or 
Reverse Merger.  In the event of (1) a sale of substantially all of the 
assets of the Company, (2) a merger or consolidation in which the Company 
is not the surviving corporation or (3) a reverse merger in which the 
Company is the surviving corporation but the shares of Common Stock 
outstanding immediately preceding the merger are converted by virtue of 
the merger into other property, whether in the form of securities, cash or 
otherwise, then any surviving corporation or acquiring corporation shall 
assume any Options outstanding under the Plan or shall substitute similar 
Options (including an award to acquire the same consideration paid to the 
stockholders in the transaction described in this subsection) for those 
outstanding under the Plan.  In the event any surviving corporation or 
acquiring corporation refuses to assume such Options or to substitute 
similar Options for those outstanding under the Plan, then with respect to 
Options held by Optionholders whose Continuous Service has not terminated, 
the vesting shall be accelerated in full, and the Options shall terminate 
if not exercised at or prior to such event.  With respect to any other 
Options outstanding under the Plan, such Options shall terminate if not 
exercised prior to such event.

11. Amendment of the Plan and Options.

     (a) Amendment of Plan.  The Board at any time, and from time to 
time, may amend the Plan.  However, except as provided in Section 10 
relating to adjustments upon changes in stock, no amendment shall be 
effective unless approved by the stockholders of the Company to the extent 
stockholder approval is necessary to satisfy the requirements of Section 
422 of the Code, Rule 16b-3 or any Nasdaq or securities exchange listing 
requirements.

     (b) Stockholder Approval.  The Board may, in its sole discretion, 
submit any other amendment to the Plan for stockholder approval, 
including, but not limited to, amendments to the Plan intended to satisfy 
the requirements of Section 162(m) of the Code and the regulations 
thereunder regarding the exclusion of performance-based compensation from 
the limit on corporate deductibility of compensation paid to certain 
executive officers.

     (c) Contemplated Amendments.  It is expressly contemplated that 
the Board may amend the Plan in any respect the Board deems necessary or 
advisable to provide eligible Employees with the maximum benefits provided 
or to be provided under the provisions of the Code and the regulations 
promulgated thereunder relating to Incentive Stock Options and/or to bring 
the Plan and/or Incentive Stock Options granted under it into compliance 
therewith.

     (d) No Impairment of Rights.  Rights under any Option granted 
before amendment of the Plan shall not be impaired by any amendment of the 
Plan unless (i) the Company requests the consent of the Optionholder and 
(ii) the Optionholder consents in writing.

     (e) Amendment of Options.  The Board at any time, and from time to 
time, may amend the terms of any one or more Options; provided, however, 
that the rights under any Option shall not be impaired by any such 
amendment unless (i) the Company requests the consent of the Optionholder 
and (ii) the Optionholder consents in writing.

12. Termination or Suspension of the Plan.

     (a) Plan Term.  The Board may suspend or terminate the Plan at any 
time.  Unless sooner terminated, the Plan shall terminate on March 11, 
2006.  No Options may be granted under the Plan while the Plan is 
suspended or after it is terminated.

     (b) No Impairment of Rights.  Rights and obligations under any 
Option granted while the Plan is in effect shall not be impaired by 
suspension or termination of the Plan, except with the written consent of 
the Optionholder.

13. Effective Date of Plan.

     The Plan shall become effective as determined by the Board, but no 
Option shall be exercised unless and until the Plan has been approved by 
the stockholders of the Company, which approval shall be within twelve 
(12) months before or after the date the Plan is adopted by the Board.



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