LYNX THERAPEUTICS INC
10-Q, 2000-11-14
MEDICINAL CHEMICALS & BOTANICAL PRODUCTS
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<PAGE>   1

                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                                    FORM 10-Q

[X]  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE
     ACT OF 1934 FOR THE QUARTERLY PERIOD ENDED SEPTEMBER 30, 2000.

                                       OR

[ ]  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES
     EXCHANGE ACT OF 1934 FOR THE TRANSITION PERIOD FROM TO _______ TO _______.

                         COMMISSION FILE NUMBER 0-22570

                             LYNX THERAPEUTICS, INC.
             (Exact name of registrant as specified in its charter)


<TABLE>
<S>                                                         <C>
           DELAWARE                                             94-3161073
(State or other jurisdiction of                              (I.R.S. Employer
 incorporation or organization)                             Identification No.)
</TABLE>


                             25861 INDUSTRIAL BLVD.
                                HAYWARD, CA 94545
                              (Address of principal
                               executive offices)


                                 (510) 670-9300
              (Registrant's telephone number, including area code)


Indicate by check mark whether the registrant, (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days.   Yes [X]   No [ ]

The number of shares of common stock outstanding as of November 3, 2000 was
11,432,010.

<PAGE>   2

                             LYNX THERAPEUTICS, INC.

                                    FORM 10-Q

                    FOR THE QUARTER ENDED SEPTEMBER 30, 2000

                                      INDEX

<TABLE>
<CAPTION>
PART I  FINANCIAL INFORMATION (UNAUDITED)                                    PAGE
<S>     <C>                                                                   <C>
ITEM 1. Financial Statements

        Condensed Consolidated Balance Sheets - September 30, 2000
        and December 31, 1999...............................................    3

        Condensed Consolidated Statements of Operations - three and
        nine months ended September 30, 2000 and 1999.......................    4

        Condensed Consolidated Statements of Cash Flows - nine months

        ended September 30, 2000 and 1999...................................    5

        Notes to Condensed Consolidated Financial Statements................    6

ITEM 2. Management's Discussion and Analysis of

        Financial Condition and Results of Operations ......................    8

ITEM 3. Quantitative and Qualitative Disclosures About Market Risk .........   15


PART II OTHER INFORMATION

ITEM 1. Legal Proceedings...................................................   16

ITEM 2. Changes in Securities and Use of Proceeds...........................   16

ITEM 3. Defaults Upon Senior Securities.....................................   16

ITEM 4. Submission of Matters to a Vote of Security Holders.................   16

ITEM 5. Other Information...................................................   16

ITEM 6. Exhibits and Reports on Form 8-K....................................   16

SIGNATURES        ..........................................................   17
</TABLE>


                                       2.

<PAGE>   3

PART I FINANCIAL INFORMATION

ITEM 1. FINANCIAL STATEMENTS

                             LYNX THERAPEUTICS, INC.

                      CONDENSED CONSOLIDATED BALANCE SHEETS
                                 (IN THOUSANDS)

<TABLE>
<CAPTION>
                                                             SEPTEMBER 30,  DECEMBER 31,
                                                                 2000          1999*
                                                             -------------  ------------
                                                                     (UNAUDITED)
<S>                                                            <C>            <C>
ASSETS
Current assets:
   Cash and cash equivalents                                   $  4,769       $ 18,050
   Short-term investments                                        15,049         12,736
   Accounts receivable                                            4,131          4,045
   Other current assets                                           1,705          1,379
                                                               --------       --------
Total current assets                                             25,654         36,210

Property and equipment:
   Leasehold improvements                                        11,356         10,347
   Laboratory and other equipment                                12,002          8,025
                                                               --------       --------
                                                                 23,358         18,372
   Less accumulated depreciation and amortization                (8,083)        (5,494)
                                                               --------       --------
Net property and equipment                                       15,275         12,878

Other non-current assets                                            697          2,550
                                                               --------       --------
                                                               $ 41,626       $ 51,638
                                                               ========       ========
LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
   Accounts payable                                            $  1,864       $    834
   Accrued compensation                                             392            356
   Deferred revenue - current portion                             5,417          8,438
   Notes payable - current portion                                1,033            944
   Other accrued liabilities                                        452            596
                                                               --------       --------
Total current liabilities                                         9,158         11,168

Deferred revenue                                                 15,753         16,896
Notes payable                                                     3,576          3,471
Other non-current liabilities                                       682            457

Stockholders' equity:
   Common stock                                                  75,671         74,606
   Notes receivable from stockholders                              (293)          (293)
   Deferred compensation                                         (1,753)        (2,444)
   Accumulated other comprehensive income (loss)                    796          1,128
   Accumulated deficit                                          (61,964)       (53,351)
                                                               --------       --------
Total stockholders' equity                                       12,457         19,646
                                                               --------       --------
                                                               $ 41,626       $ 51,638
                                                               ========       ========
</TABLE>

*The Balance Sheet at December 31, 1999 has been derived from audited financial
 statements at that date but do not include all of the information and footnotes
 required by generally accepted accounting principles for complete financial
 statements.

                             See accompanying notes.


                                       3.

<PAGE>   4

                             LYNX THERAPEUTICS, INC.

                 CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                    (IN THOUSANDS, EXCEPT PER SHARE AMOUNTS)
                                   (UNAUDITED)

<TABLE>
<CAPTION>
                                              THREE MONTHS ENDED             NINE MONTHS ENDED
                                                 SEPTEMBER 30,                  SEPTEMBER 30,
                                            -----------------------       -----------------------
                                              2000           1999           2000           1999
                                            --------       --------       --------       --------
<S>                                         <C>            <C>            <C>            <C>
Revenues:
    Technology access and service fees      $  3,425       $  1,122       $  9,275       $  2,737

Operating costs and expenses:
   Cost of services fees revenue               1,166             --          2,564             --
   Research and development                    5,868          4,261         14,634         12,427
   General and administrative                  1,568          1,057          4,593          2,778
                                            --------       --------       --------       --------
Total operating expenses                       8,602          5,318         21,791         15,205
                                            --------       --------       --------       --------

Loss from operations                          (5,177)        (4,196)       (12,516)       (12,468)

Interest income, net                             202            237            797            881
Other income/(expense)                             9             59          3,225             86
                                            --------       --------       --------       --------
Loss before provision for income taxes        (4,966)        (3,900)        (8,494)       (11,501)

Provision for income taxes                        --             50            119            206
                                            --------       --------       --------       --------
Net loss                                    $ (4,966)      $ (3,950)      $ (8,613)      $(11,707)
                                            ========       ========       ========       ========

Basic and diluted net loss per share        $  (0.44)      $  (0.36)      $  (0.76)      $  (1.06)
                                            ========       ========       ========       ========

Shares used in per share computation          11,399         11,108         11,315         11,086
                                            ========       ========       ========       ========
</TABLE>

                             See accompanying notes.


                                       4.

<PAGE>   5

                             LYNX THERAPEUTICS, INC.

                 CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS
                                 (IN THOUSANDS)
                                   (UNAUDITED)

<TABLE>
<CAPTION>
                                                             NINE MONTHS ENDED
                                                                SEPTEMBER 30,
                                                          -----------------------
                                                            2000           1999
                                                          --------       --------
<S>                                                       <C>            <C>
CASH FLOWS FROM OPERATING ACTIVITIES:
Net loss                                                  $ (8,613)      $(11,707)
Adjustments to reconcile net loss to net cash
provided by operating activities:
     Depreciation and amortization                           2,589          1,308
     Amortization of deferred compensation                     691          1,041
     Gain on sale of antisense program                      (3,119)            --
     Changes in operating assets and liabilities:
         Accounts receivable                                   (86)        (8,684)
         Other current assets                                 (326)           157
         Accounts payable                                    1,030         (4,368)
         Accrued liabilities                                  (108)           (97)
         Deferred revenue                                   (4,164)        19,762
         Non-current liabilities                               225            197
                                                          --------       --------
Net cash used in operating activities                      (11,881)        (2,391)

CASH FLOWS FROM INVESTING ACTIVITIES:
Purchases of short-term investments                        (10,081)       (16,467)
Maturities of short-term investments                        12,354         11,999
Leasehold improvements and equipment purchases              (4,986)        (3,316)
Notes receivable from officers and employees                    54           (166)
                                                          --------       --------
Net cash provided by (used in) investing activities         (2,659)        (7,950)

CASH FLOWS FROM FINANCING ACTIVITIES:
Proceeds from equipment loan                                   922          3,243
Repayments of equipment loan                                  (728)          (117)
Issuance of common stock                                     1,065            131
                                                          --------       --------
Net cash provided by financing activities                    1,259          3,257
                                                          --------       --------
Net increase (decrease) in cash and cash equivalents       (13,281)        (7,084)
Cash and cash equivalents at beginning of period            18,050         16,170
                                                          --------       --------
Cash and cash equivalents at end of period                $  4,769       $  9,086
                                                          ========       ========

Supplemental disclosure of cash flow information:
   Cash paid during the period for income taxes           $    137       $    303
                                                          ========       ========
   Cash paid during the period for interest               $    108       $     23
                                                          ========       ========
</TABLE>

                             See accompanying notes.


                                       5.

<PAGE>   6

                             LYNX THERAPEUTICS, INC.
         NOTES TO UNAUDITED CONDENSED CONSOLIDATED FINANCIAL STATEMENTS

                               SEPTEMBER 30, 2000

1.   NATURE OF BUSINESS

     Lynx Therapeutics, Inc. ("Lynx" or the "Company") is a leader in the
development and application of novel technologies for the discovery of gene
expression patterns and genomic variations important to the pharmaceutical,
biotechnology and agricultural industries. These technologies are based on
Megaclone(TM), Lynx's unique and proprietary cloning procedure, which transforms
a sample containing millions of DNA molecules into one made up of millions of
micro-beads, each of which carries approximately 100,000 copies of one of the
DNA molecules in the sample. Based on Megaclone(TM), Lynx has developed a suite
of applications that have the potential to enhance the pace, scale and quality
of genomics and genetics research programs. Currently, Lynx's principal
collaborators and customers are BASF AG, E.I. DuPont de Nemours and Company,
Aventis CropScience GmbH, Oxagen Limited, Hybrigenics S.A, Genomics
Collaborative Inc. and Molecular Engines Laboratories S.A.

2.   BASIS OF PRESENTATION

     The accompanying condensed consolidated financial statements included
herein have been prepared by the Company without audit, pursuant to the rules
and regulations promulgated by the Securities and Exchange Commission (the
"SEC"). Certain prior year amounts have been reclassified to conform to current
year presentation. Certain information and footnote disclosures normally
included in financial statements prepared in accordance with generally accepted
accounting principles have been omitted pursuant to SEC rules and regulations;
nevertheless, the Company believes that the disclosures are adequate to make the
information presented not misleading. In the opinion of management, the
financial statements contain all adjustments, consisting only of normal
recurring adjustments, necessary to present fairly the financial position,
results of operations and cash flows of the Company for the interim periods
presented. The results of operations for the three and nine months ended
September 30, 2000, are not necessarily indicative of the results for the full
year.

     The unaudited condensed consolidated financial statements include all
accounts of the Company and its wholly owned subsidiary, Lynx Therapeutics GmbH,
formed under the laws of the Federal Republic of Germany. All significant
intercompany balances and transactions have been eliminated.

     These financial statements should be read in conjunction with the audited
consolidated financial statements and notes thereto for the Company's year ended
December 31, 1999, included in its annual report on Form 10-K filed with the
SEC.

3.   SUMMARY OF SIGNIFICANT ACCOUNTING POLICIES

REVENUE RECOGNITION

     Revenues from technology access fees have generally resulted from upfront
payments from collaborators and customers who are provided access to Lynx's
technologies for specified periods. The Company receives service fees from
collaborators and customers for genomics discovery services performed by Lynx on
the biological samples they send to Lynx. Technology access fees are deferred
and recognized as revenues on a straight-line basis over the noncancelable term
of the agreement to which they relate. Payments for services and/or materials
provided by Lynx are recognized as revenues when earned over the period in which
the services are performed and/or materials are delivered, provided no other
obligations, refunds or credits exist to be applied to future work.

NET LOSS PER SHARE

     Basic earnings per share ("EPS") is computed by dividing income or loss
applicable to common stockholders by the weighted-average number of common
shares outstanding for the period, net of certain common shares outstanding
which are subject to continued vesting and the Company's right of repurchase.
Diluted EPS reflects the potential dilution of securities that could share in
the earnings of the Company, to the extent such securities are dilutive. Basic
and diluted net loss per share is equivalent for all periods presented herein
due to the Company's net loss in all periods. At September 30, 2000, options to
purchase approximately 2,203,910 shares of common stock at a weighted-average
price of $12.86 per share have been excluded from the calculation of diluted
loss per share for 2000 because the effect of inclusion would be antidilutive.
The options will be included in the calculation at such time as the effect is no
longer antidilutive, as calculated using the treasury stock method.
Approximately 20,000 common shares which are outstanding but are subject to the
Company's right of repurchase, which expires ratably over five years, have been
excluded from the calculation of basic loss per share. The repurchasable shares
will be included in the calculation of basic EPS at such time as the Company's
right of repurchase lapses.


                                       6.

<PAGE>   7

COMPREHENSIVE INCOME

     Statement of Financial Accounting Standards No. 130, "Reporting
Comprehensive Income" ("SFAS 130") establishes rules for the reporting and
presentation of comprehensive income and its components. SFAS 130 requires
unrealized gains or losses on the Company's available-for-sale securities, which
prior to adoption were reported separately in stockholders' equity, to be
included in other accumulated comprehensive income (loss).

     Total comprehensive loss during the quarters ended September 30, 2000 and
1999 was $4.0 million and $3.9 million, respectively. For the nine months ended
September 30, 2000 and 1999, total comprehensive loss amounted to $8.9 million
and $11.7 million, respectively.

RECENT ACCOUNTING PRONOUNCEMENTS

     In June 1998, the Financial Accounting Standards Board (the "FASB") issued
Statement of Financial Accounting Standards No. 133, "Accounting for Derivative
Instruments and Hedging Activities" ("SFAS 133"). SFAS 133 requires Lynx to
recognize all derivatives on the balance sheet at fair value. Derivatives that
are not hedges must be adjusted to fair value through net income. If the
derivative is a hedge, depending on the nature of the hedge, changes in the fair
value of the derivative are either offset against the change in fair value of
assets, liabilities or firm commitments through earnings or recognized in the
other comprehensive income until the hedged item is recognized in earnings. The
ineffective portion of the derivative's change in fair value will be immediately
recognized in earnings. SFAS 133 is effective for Lynx's year ending December
31, 2001. Lynx does not currently hold any derivatives and does not expect this
pronouncement to materially impact results of operations.

     In December 1999, the SEC issued Staff Accounting Bulletin No. 101,
"Revenue Recognition in Financial Statements" ("SAB 101"), which must be adopted
in the fourth quarter of 2000. SAB 101 summarizes certain areas of the Staff's
views in applying generally accepted accounting principles to revenue in
financial statements and specifically addresses revenue recognition for
non-refundable technology access fees. Lynx believes that its current revenue
recognition principles comply with SAB 101, and thus does not believe the
adoption will have a significant effect on results of operations.

     In March 2000, the FASB issued Interpretation No. 44, "Accounting for
Certain Transactions Involving Stock Compensation" ("FIN 44"), which contains
rules designed to clarify the application of APB 25. FIN 44 was effective on
July 1, 2000 and adopted by Lynx at that time. The adoption of FIN 44 did not
have a material impact on Lynx's operating results or financial position.

4.   CORPORATE COLLABORATIONS

     In August 2000, Lynx entered into a collaboration agreement with Genomics
Collaborative Inc. Scientists from both companies designed a study to conduct a
comprehensive genome-wide scan for single nucleotide polymorphisms, or SNPs,
that are associated with type 2 diabetes, also known as non-insulin dependent
diabetes mellitus. Genomics Collaborative plans to provide Lynx with over 4,000
DNA samples taken from type 2 diabetics and matched controls from Genomic
Collaborative's Global Repository(TM). Lynx plans to analyze the DNA samples
using its Megatype(TM) technology to produce a complete set of validated
diabetes-associated SNP markers. Pursuant to the terms of this agreement, the
Company and Genomics Collaborative will share equally any profits resulting from
an agreement during a specified period with a third party for the sale, license
or sublicense of the results from the collaboration.

     In September 2000, Lynx entered into a two-year research collaboration
agreement with Molecular Engines Laboratories S.A. of Paris, France, to identify
differentially expressed genes associated with tumor reversion. Under the terms
of the agreement, Lynx will receive payments from Molecular Engines Laboratories
for genomics discovery services to be performed by Lynx. Lynx will receive
royalty payments from the commercialization of any products or services stemming
from the scientific results of the research program.


                                       7.

<PAGE>   8

ITEM 2. MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS
        OF OPERATIONS

     This discussion and analysis should be read in conjunction with the
Company's financial statements and accompanying notes included in this report
and the Company's 1999 audited financial statements and notes thereto included
in its 1999 Annual Report on Form 10-K. Operating results for the three and nine
months ended September 30, 2000 are not necessarily indicative of results that
may occur in future periods.

     Except for the historical information contained herein, the following
discussion contains forward-looking statements that involve risks and
uncertainties. When used herein, the words "believe," "anticipate," "expect,"
"estimate" and similar expressions are intended to identify such forward-looking
statements. There can be no assurance that these statements will prove to be
correct. The Company's actual results could differ materially from those
discussed here. Factors that could cause or contribute to such differences
include, but are not limited to, those discussed in this section, as well as in
the Company's 1999 Annual Report on Form 10-K as filed with the SEC. Lynx
undertakes no obligation to update any of the forward-looking statements
contained herein to reflect any future events or developments.

RESULTS OF OPERATIONS

REVENUES

     Revenues for the third quarter and nine-month period ended September 30,
2000 were $3.4 million and $9.3 million, respectively, earned primarily from
technology access and service fees from our customers and collaborators. For the
corresponding third quarter and nine-month period of 1999, revenues were $1.1
and $2.7 million, respectively, earned primarily from technology access fees
from our customers and collaborators.

OPERATING COSTS AND EXPENSES

     Total operating costs and expenses were $8.6 million for the quarter ended
September 30, 2000, compared to $5.3 million in the corresponding period in the
previous year. For the nine-month period ended September 30, 2000, operating
costs and expenses were $21.8 million, compared to $15.2 million in the
corresponding period in 1999.

     For the quarter and nine-month period ended September 30, 2000, cost of
service fees were $1.2 million and $2.6 million, respectively, and reflect the
costs of providing our genomics discovery services. Research and development
expenses were $5.9 million for the quarter ended September 30, 2000, compared to
$4.3 million in the corresponding period in 1999. For the nine-month period
ended September 30, 2000, research and development expenses were $14.6 million,
compared to $12.4 million in the corresponding period in 1999. The increase in
research and development expenses for the quarter and for the nine-month period
in 2000, as compared to the same periods in 1999, was due primarily to
expenditures for scientific materials and supplies, personnel-related expenses,
and facilities expenses related to internally applying our technologies in
building a store of genomic information, and discovery programs and expanding
our technology development and implementation activities. We expect research and
development expenses to increase substantially due to planned spending for
Lynx's internal programs, ongoing technology development and implementation, as
well as new technology applications.

     General and administrative expenses increased to $1.6 million for the
quarter ended September 30, 2000, compared to $1.1 million in the corresponding
period in the previous year. For the nine-month period ended September 30, 2000,
general and administrative expenses increased to $4.6 million, compared to $2.8
million in the same period in 1999. Contributing factors to the increase in
expenses between years include increased personnel-related expenses and the
costs of outside services. We expect to continue to incur substantial
administrative expenses in support of our commercial, research and development
and business development activities.

INTEREST INCOME, NET

     Net interest income was $0.2 million and $0.8 million for the third quarter
and nine-month period ended September 30, 2000, respectively, compared to $0.2
and $0.9 million for the same respective periods in 1999. The 2000 periods
reflected a decrease in interest income due to lower average cash balances and
by higher interest expense, as compared to the 1999 periods.

OTHER INCOME, NET

     Other income was $9,000 in the quarter ended September 30, 2000, compared
to $59,000 in the corresponding period in 1999. The 2000 and 1999 amounts were
related primarily to sublease rental income on property previously occupied by
Lynx. For the nine-month period ended September 30, 2000, other income was $3.2
million, compared to $86,000 in the same period in 1999. The 2000 other income
was primarily related to a $3.1 million gain recognized from the receipt of
400,000 shares of common stock of Inex Pharmaceuticals Corporation ("Inex")
pursuant to the terms of a 1998 agreement for the sale


                                       8.

<PAGE>   9

of our antisense program to Inex. The 1999 income was attributable to a gain on
the sale of certain fixed assets no longer used in our operations and sublease
rental income, offset by compensation-related payments associated with the sale
of our former antisense therapeutics business.

INCOME TAXES

     The provision for income taxes for the quarter and nine-month periods ended
September 30, 2000 and 1999 consist entirely of the our estimated alternative
minimum tax amounts.

LIQUIDITY AND CAPITAL RESOURCES

     Net cash used in operating activities of $11.9 million for the nine-month
period ended September 30, 2000 differed from the net loss in 2000 primarily due
to a decrease in deferred revenue and the receipt of common stock from the sale
of our antisense program to Inex, partially offset by depreciation and
amortization expense, an increase in accounts payable, and in deferred
compensation expense. The 1999 amount of net cash used in operating activities
of $2.4 million differed from the net loss in 1999 primarily due to an increase
in deferred revenue from amounts received under agreements, partially offset by
an increase in accounts receivable and a decrease in accounts payable.

     Net cash used by investing activities of $2.7 million for the nine-month
period ended September 30, 2000, related primarily to capital expenditures,
partially offset by the net maturities of short-term investments. Net cash used
in investing activities of $8.0 million for the nine-month period ended
September 30, 1999 related primarily to the net purchases of short-term
investments and capital expenditures. Net cash provided by financing activities
of $1.3 million for the nine-month period ended September 30, 2000, related
primarily to the issuance of common stock upon exercise of stock option grants,
and the proceeds, net of principal repayments, under an equipment loan
arrangement. Net cash provided by financing activities of $3.3 million for the
nine-month period ended September 30, 1999, related primarily to proceeds
received under an equipment loan arrangement. Cash, cash equivalents, and
short-term investments were $19.8 million at September 30, 2000.

     In late 1998, we entered into a financing agreement with a financial
institution under which we drew down $4.8 million during 1999 for the purchase
of equipment and certain other capital expenditures. We granted the lender a
security interest in all items financed by us under this agreement. Each draw
down under the loan has a term of 48 months from the date of the draw down. The
original draw down period under the agreement expired on March 31, 2000. In
September 2000, Lynx obtained additional financing of $950,000, under an
amendment to the original financing agreement. As of September 30, 2000, the
principal balance under loans outstanding under this agreement was approximately
$4.6 million.

     We plan to use available funds for ongoing commercial and research and
development activities, working capital and other general corporate purposes and
capital expenditures. We expect capital investments during the remainder of 2000
will be comprised primarily of equipment purchases required in the normal course
of business and expenditures for leasehold improvements. We intend to invest our
excess cash in investment-grade, interest-bearing securities.

     We have obtained funding for our operations primarily through sales of
preferred and common stock to venture capital investors, institutional investors
and collaborators, revenues from contractual arrangements and interest income.
The timing and amount of funds required for specific uses by us cannot be
precisely determined at this time and will be based upon the progress and the
scope of our collaborative and independent research and development projects;
payments received under customer and collaborative agreements; our ability to
establish and maintain customer and collaborative agreements; costs included in
protecting intellectual property rights; legal and administrative costs;
additional facilities capacity needs, and the availability of alternate methods
of financing.

     We expect to incur substantial and increasing research and development
expenses and intend to seek additional financing, as needed, through contractual
arrangements with customers and collaborators and others, and through equity or
debt offerings. There can be no assurance that any additional financing required
by us will be available or, if available, will be on terms favorable to us. We
believes that, at current spending levels, our existing capital resources, and
interest income thereon, will enable it to maintain our current and planned
operations through at least the next 12 months.

ADDITIONAL BUSINESS RISKS

OUR TECHNOLOGIES ARE NEW AND UNPROVEN AND MAY NOT ALLOW US OR OUR COLLABORATORS
TO IDENTIFY GENES OR TARGETS FOR DRUG DISCOVERY.

     Our technologies are new and unproven. The application of these
technologies is in too early a stage to determine whether it can be successfully
implemented. These technologies assume information about gene expression and
gene sequences may enable scientists to better understand complex biological
processes. Relatively few therapeutic products based on gene discoveries have
been successfully developed and commercialized. Our technologies may not enable
us or our


                                       9.

<PAGE>   10
collaborators to identify genes or targets for drug discovery. To date, no
targets for drug discovery have been identified based on our technologies.

WE ARE DEPENDENT ON OUR CUSTOMERS AND COLLABORATIONS AND WILL NEED TO FIND
ADDITIONAL CUSTOMERS AND COLLABORATORS IN THE FUTURE TO DEVELOP AND
COMMERCIALIZE DIAGNOSTIC, THERAPEUTIC OR OTHER PRODUCTS.

     Our strategy for the development and commercialization of our technologies
and potential products includes entering into collaborations, service agreements
or licensing arrangements with pharmaceutical, biotechnology and agricultural
companies. We do not have the resources to develop or commercialize diagnostic,
therapeutic or other products on our own. We cannot assure you that we will be
able to negotiate additional collaborative arrangements or contracts on
acceptable terms, or at all, or that such collaborations or relationships will
be successful.

     Substantially all of our revenues have been derived from corporate
collaborations and agreements. Revenues from collaborations and other agreements
depend upon continuation of the collaborations or relationships, the achievement
of milestones and royalties derived from future products developed from our
research and technologies. If we are unable to successfully achieve milestones
or our customers and collaborators fail to develop successful products, we will
not earn the revenues contemplated under such agreements. If existing agreements
are not renewed, or if we are unable to enter into new customer or collaborative
agreements on commercially acceptable terms, our revenues may decrease, and our
activities may fail to lead to commercialized products.

     Our dependence on customer and collaborative arrangements with third
parties subjects us to a number of risks. We have limited or no control over the
resources that our collaborators may choose to devote to our joint efforts. Our
collaborators may breach or terminate their agreements with us or fail to
perform their obligations thereunder. Further, our collaborators may elect not
to develop products arising out of our collaborative arrangements or may fail to
devote sufficient resources to the development, manufacture, market or sale of
such products. Some of our customers and collaborators could also become our
competitors in the future. Our business could be harmed if our customers and
collaborators:

     o    do not develop commercially successful products using our
          technologies;

     o    develop competing products;

     o    preclude us from entering into collaborations and other agreements
          with their competitors;

     o    fail to obtain necessary regulatory approvals; or

     o    terminate their agreements with us.

WE ARE AN EARLY STAGE COMPANY, SO OUR PROFITABILITY IS UNCERTAIN AND THERE IS A
HIGH RISK OF FAILURE.

     You must evaluate us in light of the uncertainties and complexities
affecting an early stage genomics company. Our products and services are still
in the early stages of commercialization. Our technologies depend on the
successful integration of independent technologies, each of which has its own
development risks. We cannot assure you that our technologies will continue to
be successfully developed, that our services will continue to be sought by
customers and collaborators or that any products developed from our technologies
will prove to be commercially successful. Further, we cannot assure you that we
will be successful in expanding the scope of our research into new areas of
pharmaceutical, biotechnology or agricultural research. Significant research and
development, financial resources and personnel will be required to capitalize on
our technologies. Commercialization of our technologies, whether through the
sales of services, royalties or other arrangements, may not generate sufficient
or sustainable revenues to enable us to be profitable.

WE HAVE A HISTORY OF NET LOSSES. WE EXPECT TO CONTINUE TO INCUR NET LOSSES, AND
WE MAY NOT ACHIEVE OR MAINTAIN PROFITABILITY.

     We have incurred net losses each year since our inception in 1992,
including net losses of approximately $10.8 million in 1997, $4.3 million in
1998 and $6.7 million in 1999. As of September 30, 2000, we had an accumulated
deficit of approximately $62.0 million. We expect these losses to continue for
at least the next several years. The size of these net losses will depend, in
part, on the rate of growth, if any, in our revenues and on the level of our
expenses. Our research and development expenditures and general and
administrative costs have exceeded our revenues to date, and we expect research
and development expenses to increase substantially due to planned spending for
ongoing technology development and implementation, as well as new applications.
As a result, we expect our operating expenses will increase significantly in the
near term, and consequently, we will need to generate significant additional
revenues to achieve profitability. Even if we do increase our revenues and
achieve profitability, we may not be able to sustain profitability.

     Our ability to generate revenues and achieve profitability is dependent on
many factors, including:

     o    our ability to enter into additional corporate collaborations and
          agreements;

     o    our ability, or that of our customers and collaborators, to discover
          genes and targets for drug discovery;

                                      10.

<PAGE>   11

     o    our customers' and collaborators' ability to develop diagnostic,
          therapeutic or other products from our drug discovery targets; and

     o    the successful clinical testing, regulatory approval and
          commercialization of such products.

The time required to reach profitability is highly uncertain, and we cannot
assure you that we will be able to achieve profitability on a sustained basis,
if at all.

WE MAY NEED TO RAISE ADDITIONAL FUNDS IN THE FUTURE, WHICH MAY NOT BE AVAILABLE
TO US.

     We have invested significant capital in our infrastructure and in our
commercial, research and development and business development activities. We
expect our capital and operating expenditures to increase over the next several
years as we expand our operations. Our future capital requirements will depend
on many factors, including:

     o    the progress and scope of our collaborative and independent research
          and development projects;

     o    payments received under customer and collaborative agreements;

     o    our ability to establish and maintain customer and collaborative
          arrangements;

     o    the progress of the development and commercialization efforts under
          our collaborations and corporate agreements;

     o    the costs associated with obtaining access to samples and related
          information; and

     o    the costs involved in preparing, filing, prosecuting, maintaining and
          enforcing patent claims and other intellectual property rights.

     Changes to our current operating plan may require us to consume available
capital resources significantly sooner than we expect. We may be unable to raise
sufficient additional capital when we need it, on favorable terms or at all. If
our capital resources are insufficient to meet future capital requirements, we
will have to raise additional funds. The sale of equity or convertible debt
securities in the future would be dilutive to our stockholders. If we are unable
to obtain adequate funds on reasonable terms, we may be required to curtail
operations significantly or to obtain funds by entering into financing or
customer and collaborative agreements on unattractive terms.

OUR REVENUES DEPEND ON A SMALL NUMBER OF COLLABORATORS AND CUSTOMERS.

     To date, we have received a significant portion of our revenues from a
small number of collaborators and customers. For the three-month period ended
September 30, 2000, revenues from three collaborators and customers accounted
for 5%, 61% and 32% of our revenues. For the three-month period ended September
30, 1999, revenues from two collaborators and customers accounted for 41% and
59% of our revenues. For the nine-month period ended September 30, 2000,
revenues from three collaborators and customers accounted for 13%, 54% and 31%
of our total revenues. For the same period in 1999, revenues from two
collaborators and customers accounted for 39% and 61% of our total revenues. Our
operating results may be harmed, if we lose one of these collaborators or
customers and we are not able to attract new collaborators or customers.

WE DEPEND ON A SOLE SUPPLIER TO MANUFACTURE FLOW CELLS USED IN OUR MPSS
TECHNOLOGY.

     The flow cells used in our MPSS technology are obtained from a single
supplier. Our reliance on outside vendors generally, and this sole supplier in
particular, involves several risks, including:

     o    the inability to obtain an adequate supply of required components due
          to manufacturing capacity constraints, a discontinuance of a product
          by a third-party manufacturer or other supply constraints;

     o    reduced control over quality and pricing of components; and

     o    delays and long lead times in receiving materials from vendors.

THE GENOMICS INDUSTRY IS INTENSELY COMPETITIVE AND EVOLVING RAPIDLY, AND OUR
COMPETITORS MAY DEVELOP PRODUCTS AND TECHNOLOGIES THAT MAKE OURS OBSOLETE.

     The biotechnology industry is highly fragmented and is characterized by
rapid technological change. In particular, the area of genomics research is a
rapidly evolving field. Competition among entities attempting to identify genes
associated with specific diseases and to develop products based on such
discoveries is intense. Many of our competitors have substantially greater
research and product development capabilities and financial, scientific and
marketing resources than we do.

     We face, and will continue to face, competition from pharmaceutical,
biotechnology and agricultural companies, as well as academic research
institutions, clinical reference laboratories and government agencies. Some of
our competitors:

     o    are attempting to identify and patent randomly sequenced genes and
          gene fragments;


                                      11.
<PAGE>   12

     o    are pursuing a gene identification, characterization and product
          development strategy based on positional cloning; and

     o    are using a variety of different gene expression analysis
          methodologies, including the use of chip-based systems, to attempt to
          identify disease-related genes.

     In addition, numerous pharmaceutical, biotechnology and agricultural
companies are developing genomic research programs, either alone or in
partnership with our competitors. Our future success will depend on our ability
to maintain a competitive position with respect to technological advances. Rapid
technological development by others may result in our technologies and future
products becoming obsolete.

     Any products that are developed through our technologies will compete in
highly competitive markets. Our competitors may be more effective at using their
technologies to develop commercial products. Further, we cannot assure you that
our competitors will not obtain intellectual property rights that would limit
the use of our technologies or the ability to commercialize diagnostic,
therapeutic or other products using our technologies. As a result, our
competitors may be able to more easily develop technologies and products that
would render our technologies and products, and those of our customers and
collaborators, obsolete and noncompetitive.

IF WE ARE UNABLE TO ADEQUATELY PROTECT OUR PROPRIETARY TECHNOLOGIES, THIRD
PARTIES MAY BE ABLE TO USE OUR TECHNOLOGY, WHICH COULD ADVERSELY AFFECT OUR
ABILITY TO COMPETE IN THE MARKET.

     Our success depends in part on our ability to obtain patents and maintain
adequate protection of the intellectual property related to our technologies and
products. The patent positions of biotechnology companies, including our patent
position, are generally uncertain and involve complex legal and factual
questions. We will be able to protect our proprietary rights from unauthorized
use by third parties only to the extent that our proprietary technologies are
covered by valid and enforceable patents or are effectively maintained as trade
secrets. The laws of some foreign countries do not protect proprietary rights to
the same extent as the laws of the U.S., and many companies have encountered
significant problems in protecting and defending their proprietary rights in
foreign jurisdictions. We have applied, and will continue to apply, for patents
covering our technologies, processes and products as and when we deem
appropriate. However, these applications may be challenged or may fail to result
in issued patents. Our existing patents and any future patents we obtain may not
be sufficiently broad to prevent others from practicing our technologies or from
developing competing products. Furthermore, others may independently develop
similar or alternative technologies or design around our patents. In addition,
our patents may be challenged or invalidated or fail to provide us with any
competitive advantage.

     We also rely on trade secret protection for our confidential and
proprietary information. We have taken security measures to protect our
proprietary information and trade secrets, but these measures may not provide
adequate protection. While we seek to protect our proprietary information by
entering into confidentiality agreements with employees, collaborators and
consultants, we cannot assure you that our proprietary information will not be
disclosed or that we can meaningfully protect our trade secrets. In addition,
our competitors may independently develop substantially equivalent proprietary
information or may otherwise gain access to our trade secrets, which could
adversely affect our ability to compete in the market.

LITIGATION OR THIRD-PARTY CLAIMS OF INTELLECTUAL PROPERTY INFRINGEMENT COULD
REQUIRE US TO SPEND SUBSTANTIAL TIME AND MONEY AND ADVERSELY AFFECT OUR ABILITY
TO DEVELOP AND COMMERCIALIZE OUR TECHNOLOGIES AND PRODUCTS.

     Our commercial success depends in part on our ability to avoid infringing
patents and proprietary rights of third parties and not breaching any licenses
that we have entered into with regard to our technologies. Other parties have
filed, and in the future are likely to file, patent applications covering genes,
gene fragments, the analysis of gene expression and the manufacture and use of
DNA chips. We intend to continue to apply for patent protection for methods
relating to gene expression and for the individual disease genes and drug
discovery targets we discover. If patents covering technologies required by our
operations are issued to others, we may have to rely on licenses from third
parties. We cannot assure you that such licenses will be available on
commercially reasonable terms, or at all.

     Third parties may accuse us of employing their proprietary technology
without authorization. In addition, third parties may obtain patents that relate
to our technologies and claim that use of such technologies infringes these
patents. Regardless of their merit, such claims could require us to incur
substantial costs, including the diversion of management and technical
personnel, in defending ourselves against any such claims or enforcing our
patents. In the event that a successful claim of infringement is brought against
us, we may be required to pay damages and obtain one or more licenses from third
parties. We may not be able to obtain these licenses at a reasonable cost, or at
all. Defense of any lawsuit or failure to obtain any of these licenses could
adversely affect our ability to develop and commercialize our technologies and
products.

WE HAVE LIMITED EXPERIENCE IN SALES AND MARKETING AND THUS MAY BE UNABLE TO
FURTHER COMMERCIALIZE OUR TECHNOLOGIES AND PRODUCTS.


                                      12.

<PAGE>   13

     Our ability to achieve profitability depends on attracting collaborators
and customers for our technologies and products. There are a limited number of
pharmaceutical, biotechnology and agricultural companies that are potential
collaborators and customers for our technologies and products. To market our
technologies and products, we must develop a sales and marketing group with the
appropriate technical expertise. We may not be able to build such a sales force.
We cannot assure you that our sales and marketing efforts will be successful or
that our technologies and products will gain market acceptance.

OUR SALES CYCLE IS LENGTHY, AND WE MAY SPEND CONSIDERABLE RESOURCES ON
UNSUCCESSFUL SALES EFFORTS OR MAY NOT BE ABLE TO ENTER INTO AGREEMENTS ON THE
SCHEDULE WE ANTICIPATE.

     Our ability to obtain collaborators and customers for our technologies and
products depends in significant part upon the perception that our technologies
and products can help accelerate their drug discovery and genomics efforts. Our
sales cycle is typically lengthy because we need to educate our potential
collaborators and customers and sell the benefits of our products to a variety
of constituencies within such companies. In addition, we may be required to
negotiate agreements containing terms unique to each collaborator or customer.
We may expend substantial funds and management effort with no assurance that we
will successfully sell our technologies and products. Actual and proposed
consolidations of pharmaceutical companies have negatively affected, and may in
the future negatively affect, the timing and progress of our sales efforts.

WE MAY HAVE DIFFICULTY MANAGING OUR GROWTH.

     We expect to continue to experience significant growth in the number of our
employees and the scope of our operations. This growth may place a significant
strain on our management and operations. As our operations expand, we expect
that we will need to manage additional relationships with various collaborators
and customers, suppliers and other third parties. Our ability to manage our
operations and growth effectively requires us to continue to improve our
operational, financial and management controls, reporting systems and
procedures. If we are unable to manage this growth effectively, our business may
be harmed.

THE LOSS OF KEY PERSONNEL OR THE INABILITY TO ATTRACT AND RETAIN ADDITIONAL
PERSONNEL COULD IMPAIR THE GROWTH OF OUR BUSINESS.

     We are highly dependent on the principal members of our management and
scientific staff. The loss of any of these persons' services might adversely
impact the achievement of our objectives and the continuation of existing
collaborations or customer relationships. In addition, recruiting and retaining
qualified scientific personnel to perform future research and development work
will be critical to our success. There is currently a shortage of skilled
executives and employees with technical expertise, and this shortage is likely
to continue. As a result, competition for skilled personnel is intense and
turnover rates are high. Competition for experienced scientists from numerous
companies and academic and other research institutions may limit our ability to
attract and retain such personnel. We are dependent on our President and Chief
Executive Officer, Norman J.W. Russell, Ph.D., and Chairman, Sam Eletr, Ph.D.,
the loss of whose services could have a material adverse effect on our business.

WE USE HAZARDOUS CHEMICALS AND RADIOACTIVE AND BIOLOGICAL MATERIALS IN OUR
BUSINESS. ANY CLAIMS RELATING TO IMPROPER HANDLING, STORAGE OR DISPOSAL OF THESE
MATERIALS COULD BE TIME CONSUMING AND COSTLY.

     Our research and development processes involve the controlled use of
hazardous materials, including chemicals and radioactive and biological
materials. Our operations produce hazardous waste products. We cannot eliminate
the risk of accidental contamination or discharge and any resultant injury from
these materials. Federal, state and local laws and regulations govern the use,
manufacture, storage, handling and disposal of hazardous materials. We may be
sued for any injury or contamination that results from our use or the use by
third parties of these materials, and our liability may exceed our insurance
coverage and our total assets. Compliance with environmental laws and
regulations may be expensive, and current or future environmental regulations
may impair our research, development and production efforts.

ETHICAL, LEGAL AND SOCIAL ISSUES MAY LIMIT THE PUBLIC ACCEPTANCE OF, AND DEMAND
FOR, OUR TECHNOLOGIES AND PRODUCTS.

     Our collaborators and customers may seek to develop diagnostic products
based on genes we discover. The prospect of broadly available gene-based
diagnostic tests raises ethical, legal and social issues regarding the
appropriate use of gene-based diagnostic testing and the resulting confidential
information. It is possible that discrimination by third-party payors, based on
the results of such testing, could lead to the increase of premiums by such
payors to prohibitive levels, outright cancellation of insurance or
unwillingness to provide coverage to individuals showing unfavorable gene
expression profiles. Similarly, employers could discriminate against employees
with gene expression profiles indicative of the potential for high
disease-related costs and lost employment time. Finally, government authorities
could, for social or other purposes, limit or prohibit the use of such tests
under certain circumstances. We cannot assure you that ethical, legal and social
concerns about genetic testing and target identification will not adversely
affect market acceptance of our technologies and products.


                                      13.

<PAGE>   14

     Although our technology is not dependent on genetic engineering, genetic
engineering plays a prominent role in our approach to product development. The
subject of genetically modified food has received negative publicity, which has
aroused public debate. Adverse publicity has resulted in greater regulation
internationally and trade restrictions on imports of genetically altered
agricultural products. Public attitudes may be influenced by claims that
genetically engineered products are unsafe for consumption or pose a danger to
the environment. Such claims may prevent genetically engineered products from
gaining public acceptance. The commercial success of our future products may
depend, in part, on public acceptance of the use of genetically engineered
products, including drugs and plant and animal products.

IF WE DEVELOP PRODUCTS WITH OUR COLLABORATORS, AND IF PRODUCT LIABILITY LAWSUITS
ARE SUCCESSFULLY BROUGHT AGAINST US, WE COULD FACE SUBSTANTIAL LIABILITIES THAT
EXCEED OUR RESOURCES.

     We may be held liable if any product we develop with our collaborators
causes injury or is otherwise found unsuitable during product testing,
manufacturing, marketing or sale. Although we have general liability and product
liability insurance, this insurance may become prohibitively expensive or may
not fully cover our potential liabilities. Inability to obtain sufficient
insurance coverage at an acceptable cost or to otherwise protect us against
potential product liability claims could prevent or inhibit the
commercialization of products developed with our collaborators.

HEALTHCARE REFORM AND RESTRICTIONS ON REIMBURSEMENTS MAY LIMIT OUR RETURNS ON
DIAGNOSTIC OR THERAPEUTIC PRODUCTS THAT WE MAY DEVELOP WITH OUR COLLABORATORS.

     If we are successful in validating targets for drug discovery, products
that we develop with our collaborators based on those targets may include
diagnostic or therapeutic products. The ability of our collaborators to
commercialize such products may depend, in part, on the extent to which
reimbursement for the cost of these products will be available from government
health administration authorities, private health insurers and other
organizations. In the U.S., third-party payors are increasingly challenging the
price of medical products and services. The trend towards managed healthcare in
the U.S., legislative healthcare reforms and the growth of organizations such as
health maintenance organizations that may control or significantly influence the
purchase of healthcare products and services, may result in lower prices for any
products our collaborators may develop. Significant uncertainty exists as to the
reimbursement status of newly approved healthcare products, and we cannot assure
you that adequate third-party coverage will be available to enable our
collaborators to maintain price levels sufficient to realize an appropriate
return on their investment in research and product development.

OUR FACILITIES ARE LOCATED NEAR KNOWN EARTHQUAKE FAULT ZONES, AND THE OCCURRENCE
OF AN EARTHQUAKE OR OTHER CATASTROPHIC DISASTER COULD CAUSE DAMAGE TO OUR
FACILITIES AND EQUIPMENT, WHICH COULD REQUIRE US TO CEASE OR CURTAIL OPERATION.

     Our facilities are located near known earthquake fault zones and are
vulnerable to damage from earthquakes. We are also vulnerable to damage from
other types of disasters, including fire, floods, power loss, communications
failures and similar events. If any disaster were to occur, our ability to
operate our business at our facilities would be seriously, or potentially
completely, impaired. In addition, the unique nature of our research activities
could cause significant delays in our programs and make it difficult for us to
recover from a disaster. The insurance we maintain may not be adequate to cover
our losses resulting from disasters or other business interruptions.
Accordingly, an earthquake or other disaster could materially and adversely harm
our ability to conduct business.

OUR STOCK PRICE MAY BE EXTREMELY VOLATILE.

     The trading price of our common stock is subject to significant
fluctuations. The market prices of the common stock of many publicly held, early
stage biotechnology companies have in the past been, and can in the future be
expected to be, especially volatile. In addition, the securities markets have
from time to time experienced significant price and volume fluctuations that may
be unrelated to the operating performance of particular companies. The following
factors and events may have a significant and adverse impact on the market price
of our common stock:

     o    fluctuations in our operating results;

     o    announcements of technological innovations or new commercial products
          by us or our competitors;

     o    release of reports by securities analysts;

     o    developments or disputes concerning patent or proprietary rights;

     o    developments in our relationships with current or future collaborators
          or customers; and

     o    general market conditions.

Many of these factors are beyond our control. These factors may cause a decrease
in the market price of our common stock, regardless of our operating
performance.


                                      14.

<PAGE>   15

ANTI-TAKEOVER PROVISIONS IN OUR CHARTER DOCUMENTS AND UNDER DELAWARE LAW COULD
PREVENT OR DELAY A CHANGE IN CONTROL OF OUR COMPANY, EITHER OF WHICH COULD
ADVERSELY AFFECT OUR STOCK PRICE.

     Under our amended and restated certificate of incorporation, our board of
directors has the authority, without further action by the holders of our common
stock, to issue 2,000,000 additional shares of preferred stock from time to time
in series and with preferences and rights as it may designate. These preferences
and rights may be superior to those of the holders of our common stock. For
example, the holders of preferred stock may be given a preference in payment
upon our liquidation or for the payment or accumulation of dividends before any
distributions are made to the holders of common stock.

     Although we have no present intention to authorize or issue any additional
series of preferred stock, any authorization or issuance, while providing
desirable flexibility in connection with possible acquisitions and other
corporate purposes, could also have the effect of making it more difficult for a
third party to acquire a majority of our outstanding voting stock. The preferred
stock may have other rights, including economic rights senior to those of our
common stock, and, as a result, an issuance of additional preferred stock could
adversely affect the market value of our common stock. Provisions of Delaware
law may also discourage, delay or prevent someone from acquiring or merging with
us.

RECENT PRONOUNCEMENTS COULD IMPACT OUR FINANCIAL POSITION AND RESULTS OF
OPERATIONS.

     In June 1998, the Financial Accounting Standards Board (the "FASB") issued
Statement of Financial Accounting Standards No. 133, "Accounting for Derivative
Instruments and Hedging Activities" ("SFAS 133"). SFAS 133 requires Lynx to
recognize all derivatives on the balance sheet at fair value. Derivatives that
are not hedges must be adjusted to fair value through net income. If the
derivative is a hedge, depending on the nature of the hedge, changes in the fair
value of the derivative are either offset against the change in fair value of
assets, liabilities or firm commitments through earnings or recognized in the
other comprehensive income until the hedged item is recognized in earnings. The
ineffective portion of the derivative's change in fair value will be immediately
recognized in earnings. SFAS 133 is effective for Lynx's year ending December
31, 2001. Lynx does not currently hold any derivatives and does not expect this
pronouncement to materially impact results of operations.

     In December 1999, the SEC issued Staff Accounting Bulletin No. 101,
"Revenue Recognition in Financial Statements" ("SAB 101"), which must be adopted
in the fourth quarter of 2000. SAB 101 summarizes certain areas of the Staff's
views in applying generally accepted accounting principles to revenue in
financial statements and specifically addresses revenue recognition for
non-refundable technology access fees. Lynx believes that its current revenue
recognition principles comply with SAB 101, and thus does not believe the
adoption will have a significant effect on results of operations.

     In March 2000, the FASB issued Interpretation No. 44, "Accounting for
Certain Transactions Involving Stock Compensation" ("FIN 44"), which contains
rules designed to clarify the application of APB 25. FIN 44 was effective on
July 1, 2000 and adopted by Lynx at that time. The adoption of FIN 44 did not
have am material impact on our operating results or financial position.

ITEM 3. QUANTITATIVE AND QUALITATIVE DISCLOSURES ABOUT MARKET RISK

     The primary objective of the Company's investment activities is to preserve
principal while at the same time maximizing yields without significantly
increasing risk. To achieve this objective, the Company invests in highly liquid
and high-quality debt securities. The Company's investments in debt securities
are subject to interest rate risk. To minimize the exposure due to adverse
shifts in interest rates, the Company invests in short-term securities and
maintains an average maturity of less than one year. As a result, Lynx believes
it is not subject to significant interest rate risks.


                                      15.

<PAGE>   16

PART II OTHER INFORMATION

ITEM 1. LEGAL PROCEEDINGS

     None

ITEM 2. CHANGES IN SECURITIES AND USE OF PROCEEDS

     None

ITEM 3. DEFAULTS UPON SENIOR SECURITIES

     None

ITEM 4. SUBMISSION OF MATTERS TO A VOTE OF SECURITY HOLDERS

     None

ITEM 5. OTHER INFORMATION

     None

ITEM 6. EXHIBITS AND REPORTS ON FORM 8-K.

     a)   Exhibits - The following documents are filed as Exhibits to this
          report:

<TABLE>
<CAPTION>
          EXHIBIT NUMBER                 DESCRIPTION
          --------------                 -----------
<S>                                <C>
               27.1                Financial Data Schedule
</TABLE>


     b)   Reports on Form 8-K - No reports on Form 8-K were filed during the
          three-month period ended September 30, 2000.


                                      16.

<PAGE>   17

                                   SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned, thereunto duly authorized.

                                       LYNX THERAPEUTICS, INC.


                                       /s/ Norman J.W. Russell
                                       -----------------------------------------
                                       By: Norman J.W. Russell, Ph.D.
                                           President and Chief Executive Officer
                                       Date: November 14, 2000


                                       /s/ Edward C. Albini
                                       -----------------------------------------
                                       By: Edward C. Albini
                                           Chief Financial Officer
                                           (Principal Financial and
                                           Accounting Officer)
                                       Date: November 14, 2000



                                      17.

<PAGE>   18

                                 EXHIBIT INDEX

<TABLE>
<CAPTION>
          EXHIBIT NUMBER                 DESCRIPTION
          --------------                 -----------
<S>                                <C>
               27.1                Financial Data Schedule
</TABLE>


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