3 DIMENSIONAL PHARMACEUTICALS INC
SC 13G, EX-99, 2000-08-15
PHARMACEUTICAL PREPARATIONS
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                                   EXHIBIT A
                            JOINT FILING AGREEMENT

Pursuant to Rule 13d-1(k)(1) promulgated under the Securities Exchange Act of
1934, the undersigned agree to the joint filing of a Statement on Schedule 13G
(including any and all amendments thereto, and any filing on Schedule 13D
relating to the same investment) with respect to the shares of common stock, par
value $0.001 per share, of 3-Dimensional Pharmaceuticals, Inc., and further
agree that this Joint Filing Agreement be included as an Exhibit thereto.
In addition, each party to this Agreement expressly authorizes each other
party to this Agreement to file on its behalf any and all amendments to such
Statement.


Dated:  August 15, 2000.


RHO MANAGEMENT COMPANY, INC.

    By: /s/ Joshua Ruch
    --------------------------
    Name: Joshua Ruch
    Title: President



RHO MANAGEMENT TRUST II
By: RHO MANAGEMENT COMPANY, INC.
    As Investment Advisor

    By: /s/ Joshua Ruch
    --------------------------
    Name: Joshua Ruch
    Title: President



RHO MANAGEMENT TRUST IV
By: RHO MANAGEMENT COMPANY, INC.
    As Investment Advisor


    By: /s/ Joshua Ruch
    --------------------------
    Name: Joshua Ruch
    Title: President


JOSHUA RUCH

      /s/ Joshua Ruch
    --------------------------
      Name: Joshua Ruch







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