3 DIMENSIONAL PHARMACEUTICALS INC
SC 13G, 2000-12-11
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G

                    UNDER THE SECURITIES EXCHANGE ACT OF 1934

                              (AMENDMENT NO. ___ )*


                       3-DIMENSIONAL PHARMACEUTICALS, INC.
        -----------------------------------------------------------------
                                (Name of Issuer)


                    COMMON STOCK, PAR VALUE $0.001 PER SHARE
        -----------------------------------------------------------------
                         (Title of Class of Securities)


                                    88554W104
                      ------------------------------------
                                 (CUSIP Number)


                                NOVEMBER 18, 2000
               --------------------------------------------------
              (Date of Event Which Requires Filing This Statement)


       Check the appropriate box to designate the rule pursuant to which this
Schedule is filed:

                                [ ] Rule 13d-1(b)

                                [X] Rule 13d-1(c)

                                [ ] Rule 13d-1(d)



<PAGE>   2


CUSIP No.                88554W104
         -----------------------------------

    1.   Names of Reporting Persons          BIOTECH GROWTH S.A.
                                        ---------------------------------------

         I.R.S. Identification Nos. of above persons (entities only):   N/A
                                                                    -----------


    2.   Check the Appropriate Box if a Member of a Group (See Instructions)

         (a)  [X]

         (b)  [ ]


    3.   SEC  Use Only
                       --------------------------------------------------------


    4.   Citizenship or Place of Organization    REPUBLIC OF PANAMA
                                              ---------------------------------



Number of Shares            5.   Sole Voting Power                      0
Beneficially Owned by Each                                   ------------------
Reporting Person with:

                            6.   Shared Voting Power                3,010,970
                                                             ------------------


                            7.   Sole Dispositive Power                 0
                                                             ------------------


                            8.   Shared Dispositive Power           3,010,970
                                                             ------------------

    9.   Aggregate Amount Beneficially Owned
         by Each Reporting Person                        3,010,970
                                              ---------------------------------


    10.  Check if the Aggregate Amount in Row (9) Excludes Certain Shares  [ ]


    11.  Percent of Class Represented by amount in Row (9)         14.3%
                                                             ------------------


    12.  Type of Reporting Person (See Instructions)           CO
                                                     --------------------------


                                       2

<PAGE>   3


CUSIP No.                88554W104
         -----------------------------------

    1.   Names of Reporting Persons          BB BIOTECH AG
                                        ---------------------------------------

         I.R.S. Identification Nos. of above persons (entities only):   N/A
                                                                    -----------


    2.   Check the Appropriate Box if a Member of a Group (See Instructions)

         (a)  [X]

         (b)  [ ]


    3.   SEC  Use Only
                       --------------------------------------------------------


    4.   Citizenship or Place of Organization    SWITZERLAND
                                              ---------------------------------



Number of Shares            5.   Sole Voting Power                      0
Beneficially Owned by Each                                   ------------------
Reporting Person with:

                            6.   Shared Voting Power                3,010,970
                                                             ------------------


                            7.   Sole Dispositive Power                 0
                                                             ------------------


                            8.   Shared Dispositive Power           3,010,970
                                                             ------------------

    9.   Aggregate Amount Beneficially Owned
         by Each Reporting Person                        3,010,970
                                              ---------------------------------


    10.  Check if the Aggregate Amount in Row (9) Excludes Certain Shares  [ ]


    11.  Percent of Class Represented by amount in Row (9)         14.3%
                                                             ------------------


    12.  Type of Reporting Person (See Instructions)           CO
                                                     --------------------------


                                       3

<PAGE>   4


ITEM 1

        1(a) Name of Issuer:               3-DIMENSIONAL PHARMACEUTICALS, INC.
                                    --------------------------------------------

        1(b) Address of Issuer's Principal Executive Offices:

                    SUITE 104, EAGLEVIEW CORPORATE CENTER, EXTON, PA  19341
             -------------------------------------------------------------------

ITEM 2

        2(a) Name of Person Filing:   BB BIOTECH AG ("BB BIOTECH"), ON BEHALF OF
                                      ------------------------------------------
             BIOTECH GROWTH S.A. ("BIOGROWTH"), ITS WHOLLY-OWNED SUBSIDIARY AND
             -------------------------------------------------------------------
             RECORD OWNER OF THE SECURITIES.
             -------------------------------

        2(b) Address of Principal Business Office or, if none, Residence:

             BB BIOTECH AG:   VODERGASSE 3, CH-8300 SCHAFFHAUSEN, SWITZERLAND

             BIOTECH GROWTH S.A.:  CALLE 53, URBANIZACION OBARRIO, TORRE
                                   SWISS BANK, PISO 16, PANAMA CITY, ZONA 1,
                                   REPUBLIC OF PANAMA

        2(c) Citizenship:                      SWITZERLAND
                             ---------------------------------------------------

        2(d) Title of Class of Securities  COMMON STOCK, PAR VALUE $0.001
                                           ------------------------------
                                           PER SHARE
                                           --------------------


        2(e) CUSIP Number                  88554W104
                                 -----------------------------


ITEM 3

IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), OR 13d-2(b) OR (c), CHECK
WHETHER THE PERSON FILING IS A:

        a. [ ] Broker or Dealer registered under Section 15 of the Act.

        b. [ ] Bank as defined in Section 3(a)(6) of the Act.

        c. [ ] Insurance company as defined in Section 3(a)(19) of the Act.

        d. [ ] Investment company registered under section 8 of the Investment
               Company Act of 1940.

        e. [ ] An investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E);

        f. [ ] An employee benefit plan or endowment fund in accordance with
               Rule 13d-1(b)(1)(ii)(F);

        g. [ ] A parent holding company or control person in accordance with
               Rule 13d-1(b)(1)(ii)(G);

        h. [ ] A savings associations as defined in Section 3(b) of the
               Federal Deposit Insurance Act (12 U.S.C. 1813);

        i. [ ] A church plan that is excluded from the definition of an
               investment company under section 3(c)(14) of the Investment
               Company Act of 1940;

        j. [ ] Group, in accordance with Rule 13d-1(b)(1)(ii)(J).


                                       4
<PAGE>   5


ITEM 4.  OWNERSHIP

        Provide the following information regarding the aggregate number and
percentage of the class of securities of the issuer identified in Item 1.

        (a)  Amount beneficially owned:             3,010,970
                                          --------------------------------------

        (b)  Percent of class:                       14.3%
                                          --------------------------------------

        (c)  Number of shares as to which the person has:

             (i)   Sole power to vote or to direct the vote            0
                                                              ------------------

             (ii)  Shared power to vote or to direct the vote      3,010,970
                                                              ------------------

             (iii) Sole power to dispose or to direct the
                   disposition of                                      0
                                                              ------------------

             (iv) Shared power to dispose or to direct the
                  disposition of                                   3,010,970
                                                              ------------------



ITEM 5.  OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

        If this statement is being filed to report the fact that as of the date
hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following: [ ]



ITEM 6.  OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.



                                      N/A
      --------------------------------------------------------------------------



ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE
    SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY OR CONTROL PERSON.



        THIS STATEMENT IS FILED JOINTLY BY BB BIOTECH AND BIOGROWTH. BIOGROWTH
        ------------------------------------------------------------------------
        IS A WHOLLY OWNED SUBSIDIARY OF BB BIOTECH.
        ------------------------------------------------------------------------



ITEM 8.  IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP



                                      N/A
      --------------------------------------------------------------------------



ITEM 9.  NOTICE OF DISSOLUTION OF GROUP



                                      N/A

      --------------------------------------------------------------------------


                                       5
<PAGE>   6

ITEM 10.  CERTIFICATION

        By signing below I certify that, to the best of my knowledge and belief,
the securities referred to above were not acquired and are not held for the
purpose of or with the effect of changing or influencing the control of the
issuer of the securities and were not acquired and are not held in connection
with or as a participant in any transaction having that purpose or effect.



SIGNATURES

        After reasonable inquiry and the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

                                             BB BIOTECH AG



Date:       NOVEMBER 6, 2000             By:              /S/  ANDERS HOVE
        -------------------------            -----------------------------------
                                                         Signatory Authority

                                       Name:                 ANDERS HOVE
                                             -----------------------------------

                                      Title:             SIGNATORY AUTHORITY
                                             -----------------------------------


                                             BIOTECH GROWTH S.A.



Date:       NOVEMBER 6, 2000             By:            /S/  DUBRAVKA RACNJAK
        -------------------------            -----------------------------------
                                                         Signatory Authority

                                       Name:              DUBRAVKA RACNJAK
                                             -----------------------------------

                                      Title:             SIGNATORY AUTHORITY
                                             -----------------------------------


                                       6
<PAGE>   7



                                  EXHIBIT A


                            JOINT FILING STATEMENT

        Pursuant to Rule 13d-1(f)(1), we, the undersigned, hereby express our
agreement that the attached Schedule 13G (including all amendments thereto) is
filed on behalf of each of the undersigned.

                                             BB BIOTECH AG



Date:       NOVEMBER 6, 2000             By:              /S/  ANDERS HOVE
        -------------------------            -----------------------------------
                                                         Signatory Authority

                                       Name:                 ANDERS HOVE
                                             -----------------------------------

                                      Title:             SIGNATORY AUTHORITY
                                             -----------------------------------


                                             BIOTECH GROWTH S.A.



Date:       NOVEMBER 6, 2000             By:            /S/  DUBRAVKA RACNJAK
        -------------------------            -----------------------------------
                                                         Signatory Authority

                                       Name:              DUBRAVKA RACNJAK
                                             -----------------------------------

                                      Title:             SIGNATORY AUTHORITY
                                             -----------------------------------



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