NEUROCRINE BIOSCIENCES INC
10-Q, 1997-11-14
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>   1
                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION

                             WASHINGTON, D.C. 20549

                                    FORM 10-Q

(Mark One)

[X]     QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                 SECURITES AND EXCHANGE ACT OF 1934

For the quarterly period ended SEPTEMBER 30, 1997

                                       OR

[ ]     TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
                  SECURITIES AND EXCHANGE ACT OF 1934

For the transition period from ______________________ to ____________________

                         Commission file number 0-28150

                          NEUROCRINE BIOSCIENCES, INC.
             (Exact name of registrant as specified in its charter)

                 DELAWARE                              33-0525145
      (State or other jurisdiction of       (IRS Employer Identification No.)
      incorporation or organization)

                             3050 SCIENCE PARK ROAD
                           SAN DIEGO, CALIFORNIA 92121
                    (Address of principal executive offices)

                                 (619) 658-7600
              (Registrant's telephone number, including area code)

   Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Section 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days:

                             Yes [X]   No [ ]

  The number of outstanding shares of the registrant's Common Stock, no par
  value, was 17,041,235 as of October 31, 1997


                                       1
<PAGE>   2


                           NEUROCRINE BIOSCIENCES, INC
                                    FORM 10-Q
                                      INDEX
<TABLE>
<CAPTION>
PART I         FINANCIAL INFORMATION                                                                                   PAGE
                                                                                                                       ----
<S>            <C>                                                                                                     <C>
ITEM 1:        Financial Statements...................................................................................  3

               Condensed Balance Sheets as of September 30, 1997 and December 31, 1996................................  3
3

               Condensed Statements of Operations for the three months and nine months
               ended September 30, 1997 and 1996......................................................................  4

               Condensed Statements of Cash Flows for the nine months
               ended September 30, 1997 and 1996......................................................................  5

               Notes to Financial Statements..........................................................................  6

ITEM 2:        Management's Discussion and Analysis of Financial Condition
               and Results of Operations..............................................................................  7

               Overview...............................................................................................  7

               Results of Operations..................................................................................  7

               Liquidity and Capital Resources........................................................................  8

ITEM 6:        Exhibits and Reports on Form 8-K....................................................................... 10

               10.1  Lease between Science Park Center LLC (Lessor) and Neurocrine Biosciences, Inc. (Lessee) 

               10.2  Option Agreement between Science Park Center LLC (Optioner) and Neurocrine Biosciences, Inc. 
                     (Optionee) 

               10.3  Construction Loan Agreement 

               10.4  Secured Promissory Note 

               10.5  Operating Agreement for Science Park Center LLC 

               27.1  Financial Data Schedule

SIGNATURES   ......................................................................................................... 11
</TABLE>


                                       2
<PAGE>   3
PART I. FINANCIAL INFORMATION

Item 1. FINANCIAL STATEMENTS

                                 NEUROCRINE BIOSCIENCES, INC.

                                   CONDENSED BALANCE SHEETS
<TABLE>
<CAPTION>
                                                                   SEPTEMBER 30,      DECEMBER 31,
                                                                       1997               1996
                                                                   ------------      -------------
                                                                    (UNAUDITED)         (NOTE)
<S>                                                               <C>                <C>         
                            ASSETS
Current assets:
    Cash and cash equivalents                                     $ 15,094,554       $ 11,325,361
    Short-term investments, available for sale                      53,832,352         58,594,853
    Receivables under collaborative agreements                       2,631,488          1,329,513
    Other current assets                                             1,954,596            840,962
                                                                  ------------       ------------
        Total current assets                                        73,512,990         72,090,689

 Property, equipment, and leasehold improvements, net                5,340,892          3,546,420
 Licensed technology and patent application costs, net               1,306,705          1,443,403
 Other assets                                                        4,745,245            876,070
                                                                  ------------       ------------

        Total assets                                              $ 84,905,832       $ 77,956,582
                                                                  ============       ============

             LIABILITIES AND STOCKHOLDERS' EQUITY
Current liabilities:
    Accounts payable                                              $  1,692,261       $    800,157
    Accrued expenses, other current liabilities, and current
        portion of obligations under capital leases                  3,579,421          3,267,357
                                                                  ------------       ------------
        Total current liabilities                                    5,271,682          4,067,514

Long-term liabilities                                                1,101,682          1,122,100

Stockholders' equity:
    Preferred Stock, $0.001 par value, 5,000,000 shares
        authorized, no shares issued and outstanding
    Common stock, no par value:
        Authorized shares - 100,000,000
        Issued and outstanding shares - 16,951,073 and
        16,776,614 at September 30, 1997 and 
        December 31 1996, respectively                              83,496,706         82,788,513
    Accumulated deficit                                             (4,964,238)       (10,021,545)
                                                                  ------------       ------------
        Total stockholders' equity                                  78,782,468         72,766,968
                                                                  ------------       ------------

        Total liabilities and stockholders' equity                $ 84,905,832       $ 77,956,582
                                                                  ============       ============
</TABLE>





Note:   The balance sheet at December 31, 1996 has been derived from the audited
        financial statements at that date, but does not include all of the
        disclosures required by generally accepted accounting principles.

            See accompanying notes to condensed financial statements.



                                       3
<PAGE>   4

                          NEUROCRINE BIOSCIENCES, INC.

                       CONDENSED STATEMENTS OF OPERATIONS
                                   (UNAUDITED)
<TABLE>
<CAPTION>
                                                    THREE MONTHS ENDED                NINE MONTHS ENDED
                                                       SEPTEMBER 30,                    SEPTEMBER 30,
                                                -----------------------------     ------------------------------
                                                    1997             1996             1997             1996
                                                ------------     ------------     ------------     ------------
<S>                                             <C>              <C>              <C>              <C>         
Revenues under collaborative research
  agreements:
      Sponsored  research                       $  2,987,500     $  1,625,000     $  8,262,500     $  4,875,000
      Milestones                                   1,750,000               --        7,750,000        3,000,000
      Other revenue                                1,503,279          562,965        3,883,363        1,983,359
                                                ------------     ------------     ------------     ------------
                    Total revenues                 6,240,779        2,187,965       19,895,863        9,858,359

Operating expenses
      Research and development                     4,997,731        3,032,562       14,027,058        8,339,515
      General and administration                   1,566,683          717,370        4,055,133        2,012,554
                                                ------------     ------------     ------------     ------------
                    Total operating expenses       6,564,414        3,749,932       18,082,191       10,352,069
                                                ------------     ------------     ------------     ------------
Income (loss) from operations                       (323,635)      (1,561,967)       1,813,672         (493,710)

Interest income                                    1,059,015          938,005        2,892,283        1,686,220
Interest expense                                     (35,088)         (60,277)        (123,499)        (198,216)
Other income                                         257,380          279,200          696,405          382,781
                                                ------------     ------------     ------------     ------------
Income (loss) before income taxes                    957,672         (405,039)       5,278,861        1,377,075

Provision for income taxes                           145,161               --          221,554               --
                                                ------------     ------------     ------------     ------------

Net income (loss)                               $    812,511     $   (405,039)    $  5,057,307     $  1,377,075
                                                ============     ============     ============     ============

Net income (loss) per share                     $       0.04     $      (0.02)    $       0.28     $       0.09
                                                ============     ============     ============     ============

Shares used in computing net income
    (loss) per share                              18,439,495       16,764,209       18,381,141       16,160,506
                                                ============     ============     ============     ============
</TABLE>


            See accompanying notes to condensed financial statements.



                                       4
<PAGE>   5

                          NEUROCRINE BIOSCIENCES, INC.

                       CONDENSED STATEMENTS OF CASH FLOWS
                                   (UNAUDITED)
<TABLE>
<CAPTION>
                                                                       NINE MONTHS ENDED
                                                                         SEPTEMBER 30,
                                                                -------------------------------
                                                                    1997               1996
                                                                ------------       ------------
<S>                                                             <C>                <C>         
OPERATING ACTIVITIES
Net income                                                      $  5,057,307       $  1,377,075
Adjustments to reconcile net income to cash provided by
  (used in) operating activities:
    Compensation expense recognized for stock options                 98,055             56,115
    Depreciation and amortization                                    890,388            697,887
    Deferred revenue                                                 125,000            324,065
    Deferred rent                                                    292,634             41,457
Change in operating assets and liabilities: 
       Other current assets and receivables under
         collaborative agreements                                 (2,415,609)        (4,447,227)
       Other assets                                               (3,869,175)          (735,374)
       Accounts payable and accrued liabilities                    1,360,062           (576,433)
                                                                ------------       ------------
Net cash flows provided by (used in) operating activities          1,538,662         (3,262,435)

INVESTING ACTIVITIES
Purchases of short-term investments                              (85,019,124)       (64,454,483)
Sales/maturities of short-term investments                        89,932,032         23,336,485
Purchases of furniture, equipment, leasehold improvements,
 licensed technology and patent application costs                 (2,548,162)        (1,831,338)
                                                                ------------       ------------
Net cash flows provided by (used in) investing activities          2,364,746        (42,949,336)

FINANCING ACTIVITIES
Issuance of common stock, net                                        451,875         47,518,523
Principal payments on obligations under capital leases              (593,946)          (547,632)
Payments received on notes receivable from stockholders                7,856              7,853
                                                                ------------       ------------
Net cash flows (used in) provided by financing activities           (134,215)        46,978,744
                                                                ------------       ------------
Increase in cash and cash equivalents                              3,769,193            766,973

Cash and cash equivalents at beginning of period                  11,325,361          6,392,749
                                                                ------------       ------------
Cash and cash equivalents at end of period                      $ 15,094,554       $  7,159,722
                                                                ============       ============

SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION
    Interest paid                                               $    123,499       $    198,216
                                                                ============       ============
    Taxes paid                                                  $    225,000       $         --
                                                                ============       ============
</TABLE>



            See accompanying notes to condensed financial statements.




                                       5
<PAGE>   6

                          NEUROCRINE BIOSCIENCES, INC.

                     NOTES TO CONDENSED FINANCIAL STATEMENTS

1. BASIS OF PRESENTATION

   The interim unaudited condensed financial statements contained herein have
been prepared in accordance with generally accepted accounting principles for
interim financial information. Accordingly, they do not include all of the
information and footnotes required by generally accepted accounting principles
for complete financial statements. The financial statements include all
adjustments (consisting of normal recurring adjustments) necessary for a fair
presentation of the financial position, results of operations, and cash flows
for the periods presented. The results of operations for the interim periods
shown in this report are not necessarily indicative of results expected for the
full year. The financial statements should be read in conjunction with the
audited financial statements and notes for the year ended December 31, 1996,
included in the Company's Annual Report on Form 10-K filed with the Securities
and Exchange Commission.

2. NET INCOME PER SHARE

   Net income per share is computed using the weighted average number of shares
of common stock outstanding during each period. Common stock equivalent shares
from stock options, warrants, and convertible preferred shares are excluded from
the computation when their effect is antidilutive. For the three and nine month
periods ended September 30, 1997, shares used in computing net income per share
also include common equivalent shares arising from dilutive stock options,
warrants, and convertible preferred shares using the treasury stock method.
Income per share on a fully diluted basis was unchanged.

   In February 1997, the Financial Accounting Standards Board issued Statement
No. 128, "Earnings per Share," which is required to be adopted on December 31,
1997. At that time, the Company will be required to change the method currently
used to compute earnings per share and to restate all prior periods. Under the
new method, the dilutive effect of common stock equivalents will be excluded
from "basic" earnings per share, and basic earnings per share for the three and
nine months ended September 30, 1997 and 1996 will be $0.05, $0.30, ($0.02) and
$0.10, respectively. Under the new method, "diluted" earnings per share will not
be materially different than net income (loss) per share as presented herein.



                                       6
<PAGE>   7
ITEM 2.                       MANAGEMENT DISCUSSION AND ANALYSIS
                       OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS

   The following Management's Discussion and Analysis of Financial Condition and
Results of Operations of Neurocrine Biosciences, Inc. ("Neurocrine" or the
"Company") contain forward-looking statements which involve risks and
uncertainties, pertaining generally to the expected continuation of the
Company's collaborative agreements, the receipt of research payments thereunder,
the future achievement of various milestones in product development and the
receipt of payments related thereto, the potential receipt of royalty payments,
the period of time the Company's existing capital resources will meet its
funding requirements, and financial results and operations. Actual results could
differ materially from those anticipated in these forward-looking statements as
a result of various factors, including those set forth below and those outlined
in the Company's 1996 Annual Report on Form 10-K filed with the Securities and
Exchange Commission.

OVERVIEW

   Since the founding of the Company in January 1992, Neurocrine has been
engaged in the discovery and development of novel pharmaceutical products for
diseases and disorders of the central nervous and immune systems. To date,
Neurocrine has not generated any revenues from the sale of products, and does
not expect to generate any product revenues for the foreseeable future. The
Company's revenues are expected to come from its strategic alliances. The
Company has generated net income for the three and nine month periods ended
September 30, 1997 and the nine months ended September 30, 1996 primarily from
revenues from its strategic alliances. The Company does not anticipate
continuing to generate net income as its operating expenses are anticipated to
rise significantly in future periods as products are advanced through the
various stages of clinical development. Neurocrine has incurred a cumulative
deficit of approximately $5.0 million as of September 30, 1997 and expects to
incur operating losses in the future which are potentially greater than losses
in prior years.

RESULTS OF OPERATIONS

Three Months Ended September 30, 1997 Compared to Three Months Ended September
30, 1996

   Revenues increased to $6.2 million for the quarter ended September 30, 1997
compared with $2.2 million for the same period in 1996. Increased revenues were
primarily the result of increased sponsored research and development, and
milestone revenues under the Company's collaborations.

   Research and development expenses increased to $5.0 million for the quarter
ended September 30, 1997 compared with $3.0 million for the same period in 1996.
This increase reflected continued additions to scientific and clinical
development personnel, and related support expenditures, as the Company
increased its research and clinical development activities. Clinical development
costs include significant amounts which are reimbursable under corporate
collaborations. Revenues associated with such reimbursements are classified as
"Other revenue".

   General and administrative expenses increased to $1.6 million for the quarter
ended September 30, 1997 compared with $717,000 for the same period in 1996.
This increase resulted from additional administrative personnel and related
business development and professional services expenses to support the increased
research and development efforts and higher patent prosecution costs.

   Interest income increased to $1.1 million for the quarter ended September 30,
1997 compared with $938,000 for the same period in 1996. This increase was due
to increased investment income attributable to increased cash equivalents and
short-term investments.

   Net income increased to $813,000 or $0.04 per share for the quarter ended
September 30, 1997 compared with a loss of $405,000 or $0.02 per share for the
same period in 1996. The increase in net income and net income per share was
primarily attributable to increased sponsored research and development, and
milestone revenues under the Company's collaborations.

                                       7
<PAGE>   8
   The Company's revenues to date have come from funded research and achievement
of milestones under corporate collaborations, which may lead to substantial
fluctuations in the results of quarterly revenues and earnings. Accordingly,
results of one quarter are not predictive of future quarters.

Nine Months Ended September 30, 1997 Compared to Nine Months Ended September 30,
1996

   Revenues increased to $19.9 million for the nine month period ended September
30, 1997 compared with $9.9 million for the same period in 1996. Increased
revenues were primarily the result of increased sponsored research and
development, and milestone revenues under the Company's collaborations.

   Research and development expenses increased to $14.0 million for the nine
month period ended September 30, 1997 compared with $8.3 million for the same
period in 1996. This increase reflected continued additions to scientific and
clinical development personnel, and related support expenditures, as the Company
increased its research and clinical development activities. Clinical development
costs include significant amounts which are reimbursable under corporate
collaborations. Revenues associated with such reimbursements are classified as
"Other revenue".

   General and administrative expenses increased to $4.1 million for the nine
month period ended September 30, 1997 compared with $2.0 million for the same
period in 1996. This increase resulted from additional administrative personnel
and related business development and professional services expenses to support
the increased research and development efforts and higher patent prosecution
costs.

   Interest income increased to $2.9 million for the nine month period ended
September 30, 1997 compared with $1.7 million for the same period in 1996. This
increase was due to increased investment income attributable to increased cash
equivalents and short-term investments.

   Net income increased to $5.1 million or $0.28 per share for the nine month
period ended September 30, 1997 compared with $1.4 million or $0.09 per share
for the same period in 1996. The increase in net income and net income per share
was primarily due to increased sponsored research and development, and milestone
revenues under the Company's collaborations.

   The Company's revenues to date have come from funded research and achievement
of milestones under corporate collaborations, which may lead to substantial
fluctuations in the results of year-to-date revenues and earnings. Accordingly,
results of one period are not predictive of future periods.

LIQUIDITY AND CAPITAL RESOURCES

   At September 30, 1997 the Company's cash, cash equivalents, and short-term
investments totaled $68.9 million. Cash held by the Company excludes $2.6
million due from corporate collaborators of which $1.0 million had been
collected as of October 31, 1997. Total cash, cash equivalents, and short-term
investments also excludes approximately $7.7 million held by Neuroscience Pharma
(NPI) Inc. which is available to fund certain of the Company's research and
development activities.

   Cash provided by operating activities during the nine month period ended
September 30, 1997 increased to $1.5 million compared with a net use of cash of
$3.3 million for the same period in 1996. The increase was primarily the result
of increased operating revenues from the Company's collaborators.

   Cash provided by investing activities during the nine month period ended
September 30, 1997 increased to $2.4 million compared with a net use of cash of
$42.9 million for the same period in 1996. The increase was primarily the result
of timing differences in investment purchases and sales/maturities and
fluctuations in the Company's portfolio mix between cash equivalent and
short-term investment holdings.

                                       8
<PAGE>   9
   Cash used in financing activities during the nine month period ended
September 30, 1997 increased to $134,000 compared with a net provision of $47.0
million for the same period in 1996. The increase was due to a decline in cash
generated from equity offerings from the same period in 1996.

   In May 1997, the Company purchased two adjacent parcels of land in San Diego
for approximately $5.0 million in cash. In July 1997, the Company sold one
parcel of land to Science Park Center LLC, a California limited liability
company ("the LLC"), of which the Company owns a significant minority intrest,  
which the Company then agreed to lease from the LLC under a 15 year operating
lease for the purpose of constructing an expanded laboratory and office
complex. The land purchase price of approximately $3.5 million plus a future
cash payment of $368,000 will be repaid to the Company under a 10 year
promissory note bearing interest at 8.25% per annum. The Company has an option
to purchase the facility at any time during the lease at a predetermined price.
The remaining parcel will be held by the Company until such time as the
Company's growth requires additional expansion.

   Neurocrine has primarily financed its operations through proceeds of
approximately $63.6 million from the sale of Common Stock in various private and
public offerings and approximately $53.4 million from corporate collaborations.

   The Company believes that its existing capital resources, together with
interest income and future payments due under the strategic alliances, will be
sufficient to satisfy its current and projected funding requirements at least
through 2000. However, no assurance can be given that such capital resources and
payments will be sufficient to conduct its research and development programs as
planned. The amount and timing of expenditures will vary depending upon a number
of factors, including progress of the Company's research and development
programs.

   The Company's business is subject to significant risks, including but not
limited to, the risks inherent in its research and development activities,
including the successful continuation of the Company's strategic collaborations,
the successful completion of clinical trials, the lengthy, expensive and
uncertain process of seeking regulatory approvals, uncertainties associated both
with obtaining and enforcing its patents and with patent rights of others,
uncertainties regarding government reforms and of product pricing and
reimbursement levels, technological change and competition, manufacturing
uncertainties and dependence on third parties. Even if the Company's product
candidates appear promising at an early stage of development, they may not reach
the market for numerous reasons. Such reasons include the possibilities that the
product will be ineffective or unsafe during clinical trials, will fail to
receive necessary regulatory approvals, will be difficult to manufacture on
large scale, will be uneconomical to market or will be precluded from
commercialization by proprietary rights of third parties.

   Neurocrine will require additional funding for the continuation of its
research and product development programs, for progress with preclinical testing
and clinical trials, for operating expenses, for the pursuit of regulatory
approvals for its product candidates, for the costs involved in filing and
prosecuting patent applications and enforcing patent claims, if any, the cost of
product in-licensing and any possible acquisitions, and may require additional
funding for establishing manufacturing and marketing capabilities in the future.
The Company may seek to access the public or private equity markets whenever
conditions are favorable. The Company may also seek additional funding through
strategic alliances and other financing mechanisms, potentially including
off-balance sheet financing. There can be no assurance that adequate funding
will be available on terms acceptable to the Company, if at all. If adequate
funds are not available, the Company may be required to curtail significantly
one or more of its research or development programs or obtain funds through
arrangements with collaborative partners or others. This may require the Company
to relinquish rights to certain of its technologies or product candidates.

   The Company has generated net income for the three and nine month periods
ended September 30, 1997 and the nine month period ended September 30, 1996
primarily from revenues under its strategic alliances. Continued profitability
is not expected as the Company's operating expenses are anticipated to rise
significantly in future periods as products are advanced through the various
development stages. Neurocrine expects to incur additional operating expenses
over the next several years as its research, development, preclinical testing
and clinical trial activities increase. To the extent that the Company is unable
to obtain third party funding for such expenses, the Company expects that
increased expenses will result in increased losses from operations. There can be
no assurance that the Company's products under development will be successfully
developed or that its products, if successfully developed, will generate
revenues sufficient to enable the Company to earn a profit.

                                       9
<PAGE>   10
   ITEM 6.     EXHIBITS AND REPORTS ON FORM 8-K

           (a) Exhibits. The following exhibits are filed as part of, or
               incorporated by reference into, this report:
<TABLE>
<CAPTION>
                     Exhibit Number                           Description
                 -----------------------    -------------------------------------------------
                          <S>               <C>  
                          10.1*             Lease between Science Park Center LLC (Lessor)
                                            and Neurocrine Biosciences, Inc. (Lessee)
                          10.2*             Option Agreement between Science Park Center
                                            LLC (Optioner) and Neurocrine Biosciences, Inc.
                                            (Optionee)
                          10.3*             Construction Loan Agreement
                          10.4              Secured Promissory Note
                          10.5*             Operating Agreement for Science Park Center LLC
                          27.1              Financial Data Schedule

               * Certain confidential portions of this Exhibit were omitted by
                 means of blackout of the text (the "Mark"). This Exhibit has
                 been filed separately with the Secretary of the Commission
                 without the Mark pursuant to the Company's Application
                 Requesting Confidential Treatment under Rule 24b-2 under the
                 Securities Exchange Act.

</TABLE>

           (b) Reports on Form 8-K. No reports on Form 8-K were filed during the
               quarter ended September 30, 1997.


                                       10
<PAGE>   11
                                          SIGNATURES

   Pursuant to the requirements of the Securities and Exchange Act of 1934, the
registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

                                     NEUROCRINE BIOSCIENCES, INC.

Dated:  11/14/97                     /s/ Paul Hawran
                                     -----------------------------------------
                                     PAUL W. HAWRAN
                                     Senior Vice President and Chief Financial
                                     Officer

                                       11

<PAGE>   1
                                                                    EXHIBIT 10.1

                                      LEASE


                             SCIENCE PARK CENTER LLC
                                   "LANDLORD"

                                       AND

                          NEUROCRINE BIOSCIENCES, INC.
                                    "TENANT"




                                     LOT 30
                           TORREY PINES SCIENCE CENTER
                              SAN DIEGO, CALIFORNIA

*  Certain confidential portions of this Exhibit were omitted by means of
   blackout of the text (the "Mark"). This Exhibit has been filed separately
   with the Secretary of the Commission without the Mark pursuant to the
   Company's Application Requesting Confidential Treatment under Rule 24b-2
   under the Securities Exchange Act. 
<PAGE>   2
                                      LEASE

                                TABLE OF CONTENTS
<TABLE>
<CAPTION>
                                                                                          PAGE
                                                                                          ----
<S>     <C>                                                                                <C>
1.      Lease Premises.....................................................................  1
2.      Basic Lease Provisions.............................................................  1
3.      Term...............................................................................  2
4.      Construction, Possession and Commencement Date.....................................  2
5.      Rent...............................................................................  4
6.      Rental Adjustments.................................................................  5
7.      Additional Rent and Expenses.......................................................  5
8.      [Intentionally Left Blank].......................................................... 7
9.      [Intentionally Left Blank].......................................................... 7
10.     Use................................................................................. 7
11.     Brokers............................................................................ 10
12.     Holding Over....................................................................... 11
13.     Taxes and Assessments.............................................................. 11
14.     Condition of Premises.............................................................. 13
15.     Parking Facilities................................................................. 14
16.     Utilities and Services............................................................. 14
17.     Alterations........................................................................ 14
18.     Repairs and Maintenance............................................................ 15
19.     Liens.............................................................................. 16
20.     Indemnification and Exculpation.................................................... 17
21.     Insurance - Waiver of Subrogation.................................................. 18
22.     Damage or Destruction.............................................................. 21
23.     Eminent Domain..................................................................... 23
24.     Defaults and Remedies.............................................................. 25
25.     Assignment or Subletting........................................................... 28
26.     Attorney's Fees.................................................................... 30
27.     Bankruptcy......................................................................... 30
28.     Definition of Landlord............................................................. 30
29.     Estoppel Certificate............................................................... 31
30.     Removal of Property ............................................................... 31
31.     Limitation of Landlord's Liability................................................. 32
32.     Control by Landlord................................................................ 33
33.     Quiet Enjoyment.................................................................... 33
34.     Quitclaim Deed..................................................................... 33
35.     Subordination and Attornment....................................................... 34
36.     Surrender.......................................................................... 35
37.     Waiver and Modification............................................................ 35
38.     Waiver of Jury Trial and Counterclaims............................................. 35
39.     Hazardous Materials................................................................ 35
40.     Option to Extend................................................................... 39
</TABLE>

                                      - i -
<PAGE>   3

<TABLE>

<S>    <C>                                                                                 <C>
41.     Right of First Refusal to Purchase Premises........................................ 40
42.     Miscellaneous...................................................................... 41

        42.1    Terms and Headings......................................................... 41
        42.2    Examination of Lease....................................................... 41
        42.3    Time....................................................................... 41
        42.4    Covenants and Conditions................................................... 41
        42.5    Consents................................................................... 41
        42.6    Entire Agreement........................................................... 41
        42.7    Severability............................................................... 41
        42.8    Recording.................................................................. 41
        42.9    Impartial Construction..................................................... 41
        42.10   Inurement.................................................................. 42
        42.11   Force Majeure.............................................................. 42
        42.12   Notices.................................................................... 42
        42.13   Authority to Execute Lease................................................. 42

EXHIBIT "A" -- Work Letter

EXHIBIT "B" -- Form of Acknowledgement of Term Commencement Date
</TABLE>


                                       - ii -
<PAGE>   4
                                      LEASE


        THIS LEASE ("Lease") is made as of July 31, 1997, by and between SCIENCE
PARK CENTER LLC, a California limited liability company ("Landlord"), and
NEUROCRINE BIOSCIENCES, INC., a Delaware corporation ("Tenant").

        1.     LEASE PREMISES

               1.1 Landlord hereby leases to Tenant and Tenant hereby leases
from Landlord, those certain premises ("Premises") consisting of (i) that
certain real property ("Land") legally described as Lot 30 of Torrey Pines
Science Center, Unit No. 2, in the City of San Diego, County of San Diego, State
of California, according to Map thereof No. 12845, filed in the Office of the
County Recorder of San Diego County on July 23, 1991, (ii) the entirety of the
building (the "Building") to be constructed on the Land, to consist of two
levels over a subterranean area, and (iii) all landscaping, drainage,
irrigation, lighting, parking facilities, walkways, driveways and other
improvements and appurtenances related thereto, including, but not limited to,
ingress and egress to the public right-of-way as shown on the plans prepared
pursuant to the Work Letter attached hereto as Exhibit "A" (the "Improvements").
The Premises are a part of a development known as Torrey Pines Science Center.

        2.     BASIC LEASE PROVISIONS

               2.1 For convenience of the parties, certain basic provisions of
this Lease are set forth herein. The provisions set forth herein are subject to
the remaining terms and conditions of this Lease and are to be interpreted in
light of such remaining terms and conditions.

              2.1.1      Rentable Area of Premises:
                         Approximately *** square feet

              2.1.2      Basic Annual Rent: ***

              2.1.3      Monthly Installment of Basic
                         Annual Rent: ***

              2.1.4      (a) Estimated Term Commencement Date:
                             September 1, 1998

                         (b) Term Expiration Date:  *** from the
                             Term Commencement Date

              2.1.5      Permitted Use: Uses permitted in Section 10.1

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                                      - 1 -
<PAGE>   5
              2.1.6      Address for Rent Payment and Notices to Landlord:

                         Science Park Center LLC
                         4350 La Jolla Village Drive, Suite 930
                         San Diego, California 92122

                         Address for Notices to Tenant Prior to Occupancy:

                         Neurocrine Biosciences, Inc.
                         3050 Science Park Road
                         San Diego, California 92121

                         Address for Notices to Tenant After Occupancy:

                         Neurocrine Biosciences, Inc.
                         10555 Science Centre Drive
                         San Diego, California 92121

               2.2 Capitalized terms not otherwise defined in this Lease shall
have the meaning set forth in the Work Letter attached hereto as Exhibit "A"
("Work Letter").

        3.     TERM

               3.1 This Lease shall take effect upon the date of execution
hereof by each of the parties hereto, and each of the provisions hereof shall be
binding upon and inure to the benefit of Landlord and Tenant from the date of
execution hereof by each of the parties hereto.

               3.2 The approximate term of this Lease is as set forth in Section
2.1.4. The actual term of this Lease will be that period from the Term
Commencement Date through the Term Expiration Date, subject to earlier
termination of this Lease or extension of the term of this Lease as provided
herein.

        4.     CONSTRUCTION, POSSESSION AND COMMENCEMENT DATE

               4.1 Landlord shall construct the Building and Improvements (the
"Project Work") in accordance with the provisions of the Work Letter. Costs and
expenses associated with the Project Work shall be paid by Landlord in an amount
not to exceed *** and costs and expenses associated with the Project Work in
excess of such amount, if any, shall be paid by Tenant. Landlord shall commence
construction of the Project Work prior to September 1, 1997, as such date is
extended by the number of days of Tenant-Caused Delays and Force-Majeure Delays.
Tenant agrees that in the event Landlord fails to commence construction of the
Project on or before September 1, 1997, this Lease shall not be void or voidable
and Landlord shall not be liable to Tenant for any loss or damage resulting
therefrom. To "commence construction" shall mean to commence grading of the
Land. Once Landlord has commenced grading, Landlord will diligently pursue the
Project Work to completion.

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                                    - 2 -
<PAGE>   6
               4.2 Landlord shall endeavor to tender possession of the Premises,
with the Project Work Substantially Completed, to Tenant on the estimated Term
Commencement Date as set forth in Section 2.1.4(a). Tenant agrees that in the
event Landlord fails to tender possession of the Premises with the Project Work
Substantially Completed on or before the estimated Term Commencement Date, this
Lease shall not be void or voidable and Landlord shall not be liable to Tenant
for any loss or damage resulting therefrom except as expressly provided herein.
In such event, however, Tenant's obligation to pay Basic Annual Rent and
Operating Expenses shall not commence until the actual Term Commencement Date.
Without limiting the generality of the foregoing, Tenant expressly waives any
right to terminate this Lease because of delays in completion of construction of
the Project Work, except Tenant shall have the right to terminate this Lease (i)
due to nonperformance by Landlord if Landlord has not tendered possession of the
Premises with such work Substantially Completed on or before a date one year
after the estimated Term Commencement Date, as such date is extended by the
number of days of Tenant-Caused Delays and Force-Majeure Delays; or (ii) if on
or before October 1, 1997, Landlord has failed, for any reason whatsoever, to
secure (a) a construction loan for the construction of the Premises in the
approximate amount of *** or (b) grading and foundation permits
necessary for the commencement of construction of the Premises.

               4.3 The actual Term Commencement Date shall be a date selected by
Tenant no later than the later of (i) the date Landlord tenders possession of
the Premises to Tenant with all the Project Work Substantially Completed, or
(ii) the maturity date of the construction loan for the Project Work. Landlord
and Tenant shall execute a written acknowledgment of the Term Commencement Date
and the Term Expiration Date when such is established in substantially the form
attached hereto as Exhibit "B" and attach it to this Lease as Exhibit "B-1";
however, failure to execute and deliver such acknowledgement shall not affect
Tenant's liability hereunder.

               4.4 As used in Section 4.4 above and elsewhere in this Lease and
the Work Letter, the terms "Substantially Complete", "Substantially Completed",
and "Substantial Completion" shall mean the date of receipt of an interim or
final right to occupy from the City of San Diego (or check-off of line 61,
"approved to occupy," of the inspection card, or comparable line if the card is
modified), and all conditions to the issuance of a final certificate of
occupancy have been satisfied, including any offsite conditions, and the only
steps which must be taken by the appropriate governmental agency to issue the
final certificate of occupancy are purely ministerial in nature. "Substantial
Completion" is not dependent upon completion of punch-list items described in
Section 6.3 of the Work Letter or receipt of a formal certificate of occupancy.
However, "Substantial Completion" shall not be earlier than the date the air in
the Premises is balanced sufficiently to allow the conduct of Tenant's business
(as certified by the mechanical subcontractor), and shall not be later than the
date Tenant actually commences the conduct of its business on the Premises
(regardless of the state of the air balancing).

               4.5 Prior to entry by Tenant onto the Premises before the Term
Commencement Date for the purposes of installing improvements or the placement
of personal property, Tenant shall furnish to Landlord evidence satisfactory to
Landlord that insurance coverages required of Tenant under the provisions of
Article 21 are in effect. Entry by Tenant onto the Premises prior to the Term
Commencement Date for such purposes shall be subject to all of the terms and
conditions of this Lease other than the payment of Basic Annual Rent and


                                      - 3 -
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<PAGE>   7
Operating Expenses, shall not interfere with the performance by Landlord or the
Project Contractor with the Project Work, shall be limited to the last ninety
(90) days prior to the estimated Substantial Completion of the Premises, and
shall be made only with the advance written consent of Landlord, which consent
shall not be unreasonably withheld. Landlord shall allow Tenant such entry no
later than at least thirty (30) days prior to Substantial Completion of the
Premises. In the event of entry by Tenant or its agents onto the Premises prior
to the Term Commencement Date, Tenant agrees to indemnify, protect, defend and
hold Landlord harmless from any and all loss or damage to property, completed
work, fixtures, equipment, materials or merchandise, or from liability for death
of or injury to any person arising from Tenant's entry onto the Premises, except
to the extent caused by the active negligence of Landlord or its agents.
Tenant's entry prior to the Term Commencement Date shall not be deemed Tenant's
acceptance of the Premises.

               4.6 The Landlord named herein (Science Park Center LLC)
guarantees lien-free completion of the Project Work pursuant to the provisions
of this Lease and the Work Letter, regardless of any assignment of its interest
herein, unless prevented from doing so by Tenant's failure to perform its
obligations under this Lease or the Work Letter.

 .       5.     RENT

               5.1 Tenant agrees to pay Landlord as Basic Annual Rent for the
Premises the sum set forth in Section 2.1.2, subject to the rental adjustments
provided in Article 6. Basic Annual Rent shall be paid in the equal monthly
installments set forth in Section 2.1.3, subject to the rental adjustments
provided in Article 6 hereof, each in advance on the first day of each and every
calendar month during the term of this Lease.

               5.2 In addition to Basic Annual Rent, Tenant agrees to pay to
Landlord as additional rent ("Additional Rent"), at the times hereinafter
specified in this Lease, Operating Expenses as provided in Article 7, and all
other amounts that Tenant assumes or agrees to pay under the provisions of this
Lease, including without limitation any and all other sums that may become due
by reason of any default of Tenant or failure on Tenant's part to comply with
the agreements, terms, covenants and conditions of this Lease to be performed by
Tenant.

               5.3 Basic Annual Rent and Additional Rent shall together be
denominated "Rent." Except as expressly set forth in this Lease, Rent shall be
paid to Landlord, without notice, demand, abatement, suspension, deduction,
setoff, counterclaim, or defense except as set forth in Section 5.6, in lawful
money of the United States of America, at the office of Landlord as set forth in
Section 2.1.6 or to such other person or at such other place as Landlord may
from time to time designate in writing.

               5.4 In the event the term of this Lease commences or ends on a
day other than the first day of a calendar month, then the Rent for such
fraction of a month shall be prorated for such period on the basis of a thirty
(30) day month and shall be paid at the then current rate for such fractional
month prior to the commencement of the partial month.

                                     - 4 -
<PAGE>   8
               5.5 This is an absolutely net lease to Landlord. It is the intent
of the parties that the Basic Annual Rent payable under this Lease shall be an
absolutely net return to Landlord and that Tenant shall pay all costs and
expenses relating to the Premises unless otherwise expressly provided in this
Lease. Any amount or obligation herein relating to the Premises which is not
expressly declared to be that of Landlord shall be deemed to be an obligation of
Tenant to be performed by Tenant at Tenant's expense. This Lease shall not
terminate, nor shall Tenant have any right to terminate this Lease, except as
expressly provided herein.

               5.6. Tenant may, at its election and from time to time, so long
as Tenant is not in default under any provision of this Lease, make payments of
Basic Annual Rent directly to the institutional lender which funds the
construction loan for the construction of the Premises, and to the institutional
lender which ultimately provides permanent financing for the Premises (most
likely, Tokai Bank of California). Tenant may also, at it's election and from
time to time, so long as Tenant is not in default under any provision of this
Lease, and so long as Landlord is not in default under any provision of the
first mortgage encumbering the Premises, make payments of Basic Annual Rent
directly to the holder of the note secured by the second mortgage encumbering
the Premises. In no event may Tenant in any one month pay more than one monthly
installment of principal and interest under each note, and in no event may
Tenant thereby pay more than the Basic Annual Rent then due under this Lease.
Any payments made by Tenant under this Section 5.6 to the holder of either note
may be deducted by Tenant from the monthly installment of Basic Annual Rent then
due Landlord under this Lease.

        6.     RENTAL ADJUSTMENTS

               6.1 The initial Basic Annual Rent set forth in Section 2.1.2
shall be increased or decreased, as the case may be, to an amount equal to ***
of the total costs for the acquisition, development and construction of the
Premises, as determined in accordance with the pro forma attached to and
incorporated into the Work Letter.

               6.2 The Basic Annual Rent then in effect (as adjusted pursuant to
Section 6.1 and as previously increased pursuant to this Section 6.2) shall be
increased each year by ***. The first such increase shall become effective
commencing with that monthly rental installment which is first due on or after
the first (1st) anniversary of the Term Commencement Date and subsequent
increases shall become effective on the same day of each calendar year
thereafter for so long as this Lease continues in effect.

        7.     ADDITIONAL RENT AND EXPENSES

               7.1 As Additional Rent, Tenant shall pay to Landlord on the first
day of each calendar month of the term of this Lease, as Additional Rent, (i)
reimbursement and expenses of Landlord's performance of any obligations of
Tenant under this Lease, including but not limited to the provisions of Section
7.2, Article 13 (Taxes and Assessments), Article 16 (Utilities and Services),
Article 18 (Repairs and Maintenance), Article 22 (Damage or Destruction), and
Section 24.3, and (ii) costs of management services in an the amount of *** per
month (increased each year by ***.


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                                     - 5 -

<PAGE>   9
               7.2 Tenant shall pay directly to the provider of the services all
costs of any kind incurred in connection with the operation, maintenance,
repairs, replacements and management of the Premises ("Operating Expenses"),
including, by way of examples and not as a limitation upon the generality of the
foregoing, (i) costs of maintenance, repairs and replacements to improvements,
fixtures and personal property within the Premises as appropriate to maintain
the Premises in commercially reasonable condition (allowing wear and tear
consistent with commercially reasonable maintenance and repair standards
applicable to comparable buildings), including capital and structural
improvements, equipment utilized for operation and maintenance of the Premises,
and all other improvements, fixtures and personal property; (ii) costs of new
improvements and fixtures added to the Premises; (iii) costs of utilities
furnished to the Premises; (iv) sewer fees; (v) costs of cable TV when
applicable; (vi) costs of trash collection; (vii) costs of cleaning; (viii)
costs of maintenance, repairs and replacements of heating, ventilation, air
conditioning, plumbing, electrical and other systems; (ix) costs of maintenance
of landscape, grounds, drives and parking areas, including periodic resurfacing;
(x) assessments and other expenses payable pursuant to the Project Documents
(described in Section 10.2); (xi) costs of security services and devices; (xii)
costs of building supplies; (xiii) insurance premiums and portions of insured
losses deductible by reason of insurance policy terms; (xiv) costs of service
contracts and services of independent contractors retained to do work of a
nature before referenced; (xv) costs of storage and removal of Hazardous
Materials; (xvi) costs of compensation (including employment taxes and fringe
benefits) of all persons who perform regular and recurring duties connected with
the day-to-day operation and maintenance of the Premises, its equipment, the
adjacent walks, landscaped areas, drives, and parking areas, including without
limitation, janitors, floorwaxers, window-washers, watchmen, gardeners,
sweepers, and handymen; and (xvii) costs of compliance with applicable
governmental laws, ordinances, regulations and requirements.

               7.3 Landlord shall not be liable, or responsible for payment of,
any expenses of maintaining, repairing or replacing the Premises or any part
thereof.

               7.4 Tenant shall not be responsible for Operating Expenses
attributable to the time period prior to the Term Commencement Date. The
responsibility of Tenant for Operating Expenses attributable to the Premises
shall continue to the latest of (i) the date of termination of the Lease, or
(ii) the date Tenant has fully vacated the Premises.

               7.5 Operating Expenses for the calendar year in which Tenant's
obligation to pay them commences and in the calendar year in which such
obligation ceases shall be prorated. Expenses such as taxes, assessments and
insurance premiums which are incurred for an extended time period shall be
prorated based upon time periods to which applicable so that the amounts
attributed to the Premises relate in a reasonable manner to the time period
wherein Tenant has an obligation to pay Operating Expenses.

               7.6 In fulfilling its obligations set forth in Section 7.2 and
Article 18, Tenant shall maintain the roof, HVAC system, elevator and other
systems in accordance with no less than the minimum standards established by the
manufacturer and the minimum standards necessary to maintain any warranties in
effect, and Tenant may enter into such maintenance contracts as Tenant
determines is reasonably necessary in order to do so. Landlord shall have the
right, upon


                                     - 6 -
<PAGE>   10
reasonable notice, to inspect and copy any such maintenance contracts, as well
as records of maintenance conducted by Tenant or any such service provider.

               7.7 Landlord shall have the right, upon reasonable notice, to
inspect and copy documents showing in reasonable detail the actual expenses paid
by Tenant pursuant to Section 7.2, Article 13 (Taxes and Assessments), and
Article 16 (Utilities and Services) of this Lease. Tenant shall maintain such
documents as are reasonably necessary for such purpose for a period of not less
than three (3) years.

        8.     [INTENTIONALLY LEFT BLANK]

        9.     [INTENTIONALLY LEFT BLANK]

 .       10.    USE

               10.1 Tenant may use the Premises for any of those purposes, and
only those purposes, allowed by (i) the City of San Diego Scientific Research
Zone Ordinance in effect from time to time and as applicable to the Premises,
(ii) any other applicable laws, regulations, ordinances, requirements, permits
and approvals applicable to the Premises, and (iii) all covenants, conditions
and restrictions in the Project Documents (defined in the following Section
10.2) or otherwise recorded against the Land, and shall not use the Premises, or
permit or suffer the Premises to be used, for any other purpose without the
prior written consent of Landlord. Landlord acknowledges that Tenant's
activities may include scientific research and development pertaining to
pharmaceuticals (including radio-active materials and other regulated
substances), corporate and other office space, ancillary manufacturing
capabilities, and vivarium facilities. Tenant may change the use of the Premises
from time to time as long as such changed use is authorized by this Section 10.1
or may otherwise be legally permissible with the consent of Landlord, which
consent shall not be unreasonably withheld.

               10.2 Tenant shall conduct its business operations and use the
Premises in compliance with all federal, state, and local laws, regulations,
ordinances, requirements, permits and approvals applicable to the Premises, and
the Project Documents described below. Tenant shall not use or occupy the
Premises in violation of any law or regulation, the Project Documents, or the
certificate of occupancy issued for the Building, and shall, upon five (5) days'
written notice from Landlord, discontinue any use of the Premises which is
declared by any governmental authority having jurisdiction to be a violation of
law, the certificate of occupancy, or any of the Project Documents. To the
extent any use allowed by this Lease conflicts with uses allowed by the Project
Documents, the Project Documents shall govern.

                        Tenant shall comply with any direction of any
governmental authority having jurisdiction which shall, by reason of the nature
of Tenant's use or occupancy of the Premises, impose any duty upon Tenant or
Landlord with respect to the Premises or with respect to the use or occupation
thereof, including any duty to make structural or capital improvements,
alterations, repairs and replacements to the Premises.

                                     - 7 -
<PAGE>   11
                        The "Project Documents" include the following documents,
as they may be amended from time to time:

                         (a) "Project Plans", as described in the Work Letter;

                         (b) Hazardous Material Documents, as such are defined
in Section 39.5;

                         (c) Declaration of Covenants, Conditions and
Restrictions for Torrey Pines Science Center (Unit 2) dated June 22, 1994, and
recorded on June 27, 1994 as File No. 1994-0405385 of the Official Records of
San Diego County, California ("CC&Rs");

                         (d) Articles of Incorporation and Bylaws of Torrey 
Pines Science Center Association for Unit 2;

                         (e) Planned Industrial Development Permit No. 86-0884
and Planning Director Resolution No. 7658, dated September 26, 1988, as amended
to incorporate the conditions of approval of Coastal Development Permit No.
6-88-504, and including a copy of the City regulations for the SR Zone, and
amended PID 96-0738;

                         (f) Coastal Development Permit No. 6-88-504, approved
February 5, 1991, and all conditions of approval thereof;

                         (g) Transportation Demand Management Program for Torrey
Pines Science Center, prepared by the North City TMA Network, dated January 24,
1990;

                         (h) Torrey Pines Science Center Signage Guidelines and
Criteria, prepared by Graphics Solutions, dated November 17, 1989;

                         (i) Final Map No. 12845;

                         (j) Provisions of the SR Zone and other applicable
zoning as such may be adopted or amended by the City of San Diego from time to
time;

                         (k) Preliminary Title Report issued by Chicago Title
Company dated as of June 6, 1997, and identified as Order No. 007353168, as
modified by that Supplemental Report dated June 16, 1997, as further modified by
that Supplemental Letter dated June 17, 1997, reflecting the status of title to
the Land, together with a plat of all easements and copies of all underlying
documents referred to therein;

                         (l) Preliminary Geotechnical Investigation prepared by
Leighton Associates dated December 19, 1989;

                         (m) As-Graded Geotechnical Report prepared by Leighton
Associates dated December 12, 1991;

                                     - 8 -
<PAGE>   12
                         (n) Grading Plans for Torrey Pines Science Center Unit
2, prepared by Rick Engineering and approved by the City Engineer on March 13,
1991, and a Certificate from Rick Engineering indicating that the Property has
been graded in conformance with such Grading Plans;

                         (o) Phase I Environmental Site Assessment prepared by
Harding Lawson Associates dated October 19, 1988;

                         (p) Phase II Environmental Site Assessment prepared by
Harding Lawson Associates dated April 17, 1989;

                         (q) Updated Phase 1 Environmental Site Assessment
prepared by Harding Lawson Associates dated April 29, 1994;

                         (r) Any updated Environmental Site Assessment prepared
as a part of this transaction;

                         (s) Documents evidencing the release of the Property
from the Licenses described in Section 10.3 of the Lease;

                        (t) Declaration of Restrictions and Maintenance
Agreement executed by Chevron Land and Development Company and recorded on
February 15, 1990 as File No. 90-086015 of the Official Records of San Diego
County, California.

               10.3 Tenant understands and acknowledges that property within two
thousand feet of the Premises, and of which the real property underlying the
Premises was originally a part, is used for commercial engineering and
manufacturing in the field of nuclear power, including the use, operation and/or
production of high temperature gas-cooled reactors, radioisotope and
radiopharmaceutical substances, fusion, and research and development activities
related thereto. Tenant understands that the real property underlying the
Premises has been investigated and evaluated by the United States Nuclear
Regulatory Agency ("NRC") and released from any further NRC licensing or
oversight responsibility. Tenant understands that low-level radioactive wastes
may be present on the property underlying the Premises. Tenant has made its own
determination that the physical condition of the property as described herein
does not interfere with Tenant's intended use of the Premises, and is not
relying on any representation or warranty, express or implied, of Landlord or
Landlord's Agents (as defined in Section 20.1 below) in that regard.

               10.4 Tenant shall not do or permit to be done anything which will
invalidate or increase the cost (unless Tenant agrees to pay such increased
cost) of any fire, extended coverage or any other insurance policy covering the
Premises, or which will make such insurance coverage unavailable on commercially
reasonable terms and conditions, and shall comply with all rules, orders,
regulations and requirements of the insurers of the Premises.

               10.5 Tenant shall comply with the Americans with Disabilities Act
of 1990 ("ADA"), and the regulations promulgated thereunder, as amended from
time to time. All


                                     - 9 -
<PAGE>   13
responsibility for compliance with the ADA relating to the Premises and the
activities conducted by Tenant within the Premises shall be exclusively that of
Tenant and not of Landlord, including any duty to make structural or capital
improvements, alterations, repairs and replacements to the Premises. Any
alterations to the Premises made by Tenant for the purpose of complying with the
ADA or which otherwise require compliance with the ADA shall be done in
accordance with Article 17 of this Lease; provided, that Landlord's consent to
such alterations shall not constitute either Landlord's assumption, in whole or
in part, of Tenant's responsibility for compliance with the ADA, or
representation or confirmation by Landlord that such alterations comply with the
provisions of the ADA. However, nothing in this Lease shall be construed to
require Tenant to make structural or capital improvements, alterations, repairs
or replacements to comply with ADA unless and until required to do so by order
of any government entity or court of law exercising proper jurisdiction with
regard thereto, subject to any right to appeal or otherwise contest any such
order.

               10.6 Tenant may install signage on and about the Premises to the
extent permitted by, and in conformity with, applicable provisions of the
Project Documents and the City of San Diego Sign Ordinance. Tenant acknowledges
it is familiar with the restrictions of the Project Documents and the City of
San Diego Sign Ordinance, and is not relying on any representations or warranty
of Landlord regarding the number, size or location of any signage. The expense
of design, permits, purchase and installation of any signs shall be the
responsibility of Tenant and the cost thereof shall be borne by Tenant. At the
termination of the Lease, all signs shall be the property of Tenant and may be
removed from the Premises by Tenant, subject to the provisions of Article 36. In
the event Tenant receives permission from the City of San Diego under the Sign
Ordinance for signage which is not allowed by other Project Documents, Landlord
shall reasonably cooperate with Tenant in an effort to amend such other Project
Documents to allow such signage.

               10.7 No equipment shall be placed at a location within the
Building other than a location designed to carry the load of the equipment.
Equipment weighing in excess of floor loading capacity shall not be placed in
the Building.

               10.8 Tenant shall not use or allow the Premises to be used for
any unlawful purpose, nor shall Tenant cause, maintain or permit any nuisance or
waste in, on, or about the Premises.

        11.    BROKERS

               11.1 Landlord and Tenant represent and warrant one to the other
that there have been no dealings with any real estate broker or agent in
connection with the negotiation of this Lease other than CB CommerciAl (Neil
Fox), whose commission shall be paid by Landlord. Each shall indemnify, defend,
protect, and hold harmless the other from any claim of any other broker as a
result of any act or agreement of the indemnitor.

               11.2 Tenant represents and warrants that no broker or agent has
made any representation or warranty relied upon by Tenant in Tenant's decision
to enter into this Lease other than as contained in this Lease.

                                     - 10 -
<PAGE>   14
        12.    HOLDING OVER

               12.1 If, with Landlord's consent, Tenant holds possession of all
or any part of the Premises after the expiration or earlier termination of this
Lease, Tenant shall become a tenant from month to month upon the date of such
expiration or earlier termination, and in such case Tenant shall continue to pay
in accordance with Article 5 the Basic Annual Rent as adjusted from the Term
Commencement Date in accordance with Article 6, together with Operating Expenses
in accordance with Article 7 and other Additional Rent as may be payable by
Tenant, and such month-to-month tenancy shall be subject to every other term,
covenant and condition contained herein.

               12.2 If Tenant remains in possession of all or any portion of the
Premises after the expiration or earlier termination of the term hereof without
the express written consent of Landlord, Tenant shall become a tenant at
sufferance upon the terms of this Lease except that monthly rental shall be
equal to one hundred twenty five percent (125%) of the Basic Annual Rent in
effect during the last twelve (12) months of the Lease term.

               12.3 Acceptance by Landlord of Rent after such expiration or
earlier termination shall not result in a renewal or reinstatement of this
Lease.

               12.4 The foregoing provisions of this Article 12 are in addition
to and do not affect Landlord's right to re-entry or any other rights of
Landlord under Article 24 or elsewhere in this Lease or as otherwise provided by
law.

        13.    TAXES AND ASSESSMENTS

               13.1 Tenant shall pay and discharge as they become due, promptly
and before delinquency, all taxes, assessment, rates, charges, license fees,
municipal liens, levies, excises or imposts, whether general or special, or
ordinary or extraordinary, of every name, nature, and kind whatsoever, including
all governmental charges of whatsoever name, nature, or kind, which may be
levied, assessed, charged, or imposed, or may become a lien or charge on the
Premises, or any part thereof, or any improvements now or hereafter thereon, or
on Landlord by reason of its ownership of the Premises or any part thereof,
during the entire term hereof, saving and excepting only those taxes hereinafter
in this Article 13 specifically excepted.

               13.2 Specifically and without in any way limiting the generality
of the foregoing, Tenant shall pay any and all special assessments or levies or
charges made by any municipal or political subdivision for local improvements,
and shall pay the same in cash as they shall fall due and before they shall
become delinquent and as required by the act and proceedings under which any
such assessments or levies or charges are made by any municipal or political
subdivision. If the right is given to pay either in one sum or in installments,
Tenant may elect either mode of payment and its election shall be binding on
Landlord. If by making an election to pay in installments, any of the
installments shall be payable after the termination of this Lease or any
extended term thereof, the unpaid installments shall be prorated as of the date
of termination, and amounts payable after said date shall be paid by Landlord.
All other taxes and charges payable under this Article 13 shall be prorated as
of and payable at the commencement 


                                     - 11 -
<PAGE>   15

and expiration of the term of this Lease, as the case may be. Landlord shall not
during the term of this Lease undertake any action to place any special
assessments, levies or charges on the Premises without first obtaining the prior
written approval of Tenant, other than those due to new construction, those
payable under any of the Project Documents, and those imposed by the City of San
Diego or other government entity over which Landlord has no control. If Landlord
does undertake such action without Tenant's approval, Landlord, and not Tenant,
shall pay any special assessments, levies or charges sought by such action.

               13.3 Anything in this Article 13 to the contrary notwithstanding,
Tenant shall not be required to pay any estate, gift, inheritance, succession,
franchise, income, or excess profits taxes that may be payable by Landlord or
Landlord's legal representative, successors, or assigns.

               13.4 Any and all rebates on account of taxes, rates, levies,
charges or assessments required to be paid and paid by Tenant under the
provisions of this Lease shall belong to Tenant, and Landlord will, on the
request of Tenant, execute any receipts, assignments, or other acquittances that
may be necessary in order to secure the recovery of the rebates, and will pay
over to Tenant any rebates that may be received by Landlord.

               13.5 Within ninety (90) days following the conclusion of each
calendar year during the term of this Lease, and at such more frequent times as
Landlord may reasonably request, Tenant shall obtain and deliver to Landlord
receipts or duplicate receipts or copies thereof evidencing payment of all
taxes, assessments and other items required hereunder to be paid by Tenant,
together with an accounting showing in reasonable detail the taxes, assessments
and other items paid.

               13.6 Tenant shall pay not less than ten (10) days before
delinquency taxes levied against any improvements, fixtures, equipment and
personal property of Tenant or Landlord in or about the Premises, including any
and all personal property installed as part of the Project Work.

               13.7 If Tenant shall in good faith desire to contest the validity
or amount of any tax, assessment, levy, or other governmental charge herein
agreed to be paid by Tenant, Tenant shall be permitted to do so, and to defer
the payment of said tax or charge, the validity or amount of which Tenant is so
contesting, until final determination of the contest, by giving to Landlord
written notice thereof prior to the commencement of any contest, which shall be
at least fifteen (15) days prior to delinquency, and by protecting Landlord on
demand by a good and sufficient surety bond against any tax, levy, assessment,
rate or governmental charge, and from any costs, penalties, interest, liability,
or damage arising out of a contest. Landlord shall not be required to join in
any proceeding or contest brought by Tenant unless the provisions of any law
require that the proceeding or contest be brought by or in the name of Landlord.
In that case, Landlord shall join in the contest or permit it to be brought in
Landlord's name so long as Landlord is not required to bear any costs. Tenant,
on final determination of the contest, shall immediately pay or discharge any
decision or judgment rendered, together with all costs, charges, interest and
penalties incidental to the decision or judgment.


                                     - 12 -
<PAGE>   16


               13.8 To the extent Tenant fails to make any payment required by
this Article 13 and Landlord does so on Tenant's behalf, Tenant shall reimburse
Landlord for the cost thereof pursuant to the provisions of Sections 7.1 and
24.3 of this Lease.

        14.    CONDITION OF PREMISES

               14.1 Tenant acknowledges that neither Landlord nor any agent of
Landlord has made any representation or warranty, express or implied, with
respect to the condition of the Premises, or to the Project Work, except as set
forth herein, or with respect to their suitability for the conduct of Tenant's
business.

               14.2 Upon Substantial Completion of the Premises, Tenant shall
accept the Premises, including the Project Work, in the condition in which they
then exist, and shall waive any right or claim Tenant may have against Landlord
for any cause directly or indirectly arising out of the condition or delay in
delivery of possession of the Premises, appurtenances thereto, the improvements
thereon and the equipment thereof, except for (i) the warranties made by
Landlord under Section 14.4 to the extent thereof, (ii) responsibility for
covenants and representations made by Landlord in Section 39.8, (iii) the
obligation to deliver the Premises lien-free pursuant to Section 35.4, (iv) the
completion of punch-list items pursuant to Section 6.3 of the Work Letter, and
(v) Tenant's right to terminate this Lease pursuant to Section 4.2 hereof.
Tenant shall thereafter indemnify, defend, protect and hold Landlord harmless
from liability, as provided in Article 20 of the Lease.

               14.3 Tenant's taking possession of the Premises and acceptance of
the Premises shall not constitute a waiver of any claims based upon warranty or
defect in regard to design, materials, or construction of the Building and
Improvements against the design professional, contractor, materialman,
manufacturer, or other responsible party (other than Landlord, whose liability
is described in Section 14.4 below), nor for failure of any such party (other
than Landlord) to comply with all applicable building code requirements
(including but not limited to seismic Zone 4 regulations), laws, rules, orders,
ordinances, directions, regulations, permits, approvals, and requirements of all
governmental agencies, offices, departments, bureaus and boards having
jurisdiction, nor for failure to comply with the rules, orders, directions,
regulations, and requirements of any applicable fire rating bureau. Landlord
hereby assigns to Tenant, and Tenant shall have the benefit of, on a
non-exclusive basis, any and all warranties with respect to the design,
materials and construction of the Premises which are assignable to Tenant,
together with all other rights and claims it may have against any design
professional, contractor, materialman, manufacturer, or other responsible party,
or from applicable insurance policies. Landlord and Tenant agree to cooperate
with regard to the enforcement of all such warranties, rights and claims. All
such warranties, rights and claims shall revert to Landlord exclusively upon the
expiration or earlier termination of this Lease. Tenant shall comply with
whatever maintenance and similar standards are required to maintain any
applicable warranties in affect.

               14.4 Landlord warrants to Tenant that the Building and
Improvements will be, on Substantial Completion, built in a good and workmanlike
manner and in substantial compliance with the Project Plans and all applicable
building code requirements (including but 

                                     - 13 -
<PAGE>   17
not limited to seismic Zone 4 regulations), laws, rules, orders, ordinances,
directions, regulations, permits, approvals, and requirements of all
governmental agencies, offices, departments, bureaus and boards having
jurisdiction, and with the rules, orders, directions, regulations, and
requirements of any applicable fire rating bureau. However, Tenant's remedies
for breach of any warranty set forth herein shall be limited to enforcement of
claims against the design professional, contractor, materialman, manufacturer,
or other responsible party pursuant to Section 14.3 hereof, and Landlord shall
not be personally liable therefore. Landlord shall not be sued or named as a
party in any suit or action to enforce any such warranty except as may be
necessary to secure jurisdiction of Landlord or to the extent necessary to
enforce any such warranty. Landlord shall not be required to answer or otherwise
plead to any complaint and no judgment will be taken or writ of execution levied
against Landlord with respect thereto.

        15.    PARKING FACILITIES

               15.1 Tenant acknowledges that interior and exterior areas used
for Tenant's equipment, Hazardous Material enclosures, trash enclosures,
mechanical systems, and the like will reduce available parking.

               15.2 Tenant shall not place any equipment, storage containers or
any other property on the surface parking area except in accordance with the
Project Plans or as otherwise approved by Landlord, which approval shall not be
unreasonably withheld, or allowed by the Project Documents.

        16.    UTILITIES AND SERVICES

               16.1 Tenant shall pay directly to the provider, prior to
delinquency, for all water, gas, electricity, telephone, sewer, and other
utilities which may be furnished to the Premises during the term of this Lease,
together with any taxes thereon.

               16.2 Landlord shall not be liable for, nor shall any eviction of
Tenant result from, any failure of any such utility or service, provided such
failure is not due to the gross negligence or willful misconduct of Landlord,
and in the event of such failure Tenant shall not be entitled to any abatement
or reduction of Rent, nor be relieved from the operation of any covenant or
agreement of this Lease, and Tenant waives any right to terminate this Lease on
account thereof.

        17.    ALTERATIONS

               17.1 Tenant shall make no alterations, additions or improvements
(hereinafter in this section, "improvements") in or to the Premises, other than
interior non-structural alterations, additions or improvements, without
Landlord's prior written consent, which shall not be unreasonably withheld.
Tenant shall deliver to Landlord final plans and specifications and working
drawings for the improvements to Landlord, and Landlord shall have fifteen (15)
days thereafter to grant or withhold its consent. If Landlord does not notify
Tenant of its decision within the fifteen (15) days, Landlord shall be deemed to
have given its approval.

                                     - 14 -
<PAGE>   18
               17.2 If a permit is required to construct the improvements,
Tenant shall deliver a completed, signed-off inspection card to Landlord within
ten (10) days of completion of the improvements, and shall promptly thereafter
obtain and record a notice of completion and deliver a copy thereof to Landlord.

               17.3 The improvements shall be constructed only by licensed
contractors approved by Landlord, which approval shall not be unreasonably
withheld. Any such contractor must have in force a general liability insurance
policy of not less than $2,000,000 or such higher limits as Landlord may
reasonably require, which policy of insurance shall name Landlord as an
additional insured. Tenant shall provide Landlord with a copy of the contract
with the contractor prior to the commencement of construction.

               17.4 Tenant agrees that any work by Tenant shall be accomplished
in such a manner as to permit any fire sprinkler system and fire water supply
lines to remain fully operable at all times except when minimally necessary for
building reconfiguration work.

               17.5 Tenant covenants and agrees that all work done by Tenant
shall be performed in full compliance with all laws, rules, orders, ordinances,
directions, regulations, permits, approvals, and requirements of all
governmental agencies, offices, departments, bureaus and boards having
jurisdiction, and in full compliance with the rules, orders, directions,
regulations, and requirements of any applicable fire rating bureau. Tenant shall
provide Landlord with "as-built" plans showing any change in the Premises within
thirty (30) days after completion.

               17.6 Before commencing any work (other than interior
non-structural alterations, additions or improvements), Tenant shall give
Landlord at least five (5) days' prior written notice of the proposed
commencement of such work and, for any such work which exceeds One Hundred
Thousand Dollars ($100,000.00) in cost, if required by Landlord, secure at
Tenant's own cost and expenses a completion and lien indemnity bond approved by
Landlord, which approval will not be unreasonably withheld.

        18.    REPAIRS AND MAINTENANCE

               18.1 Tenant shall, throughout the term of this Lease, at its own
cost and expense (subject to recovery under any warranties assigned to Tenant
under Section 14.3), and without any cost or expense to Landlord, keep and
maintain in good, sanitary and neat order, condition, and repair, the Premises
and every part thereof (subject to wear and tear consistent with commercially
reasonable maintenance and repair standards applicable to comparable buildings),
including structural and capital improvements, all improvements, fixtures,
equipment and personal property built or installed in the Premises, and all
appurtenances thereto, including but not limited to sidewalks, parking areas,
curbs, roads, driveways, lighting standards, landscaping, sewers, water, gas and
electrical distribution systems and facilities, drainage facilities, and all
signs, both illuminated and non-illuminated that are now or hereafter on the
Premises. Without in any way limiting the foregoing, Tenant shall maintain the
lines designating the parking spaces in good condition and paint the same as
often as may be necessary, so that they are easily discernable at all times;
resurface the parking areas as necessary to maintain it in good condition; paint
any exterior portions of the Building as necessary to maintain them in good


                                     - 15 -
<PAGE>   19
condition; maintain the roof in good condition; and to take all reasonable
precautions to insure that the drainage facilities of the roof are not clogged
and are in good operable condition at all times.

               18.2 Tenant shall at all times during the term of this Lease, and
at Tenant's expense, maintain the exterior of the Building, the parking areas,
landscaping and all other portions of the Premises visible from the surrounding
streets in a commercially reasonable condition, and shall maintain sightly
screens, barricades or enclosures around any waste or storage areas.

               18.3 Tenant hereby waives Civil Code Sections 1941 and 1942
relating to a landlord's duty to maintain the Premises in a tenantable
condition, and the under said sections or under any law, statute or ordinance
now or hereafter in effect to make repairs at Landlord's expense.

               18.4 There shall be no abatement of Rent and no liability of
Landlord by reason of any injury to or interference with Tenant's business
arising from the making of any repairs, alterations or improvements in or to any
portion of the Premises, or in or to improvements, fixtures, equipment and
personal property therein. If repairs or replacements become necessary which by
the terms of this Lease are the responsibility of Tenant and Tenant fails to
make the repairs or replacements, Landlord may do so pursuant to the provisions
of Section 24.3 of this Lease.

        19.    LIENS

               19.1 Tenant shall keep the Premises and every part thereof free
from any liens arising out of work performed, materials furnished or obligations
incurred by Tenant. Tenant further covenants and agrees that any mechanic's lien
filed against the Premises for work claimed to have been done for, or materials
claimed to have been furnished to, Tenant, will be discharged by Tenant, by bond
or otherwise, within thirty (30) days after the filing thereof (or within ten
(10) days after the filing thereof if requested by Landlord as necessary to
facilitate a pending sale or refinancing), at the cost and expense of Tenant.

               19.2 Should Tenant fail to discharge any lien of the nature
described in Section 19.1, Landlord may at Landlord's election pay such claim or
post a bond or otherwise provide security to eliminate the lien as a claim
against title and the cost thereof shall be immediately due from Tenant as
Additional Rent.

               19.3 In the event Tenant shall lease or finance the acquisition
of office equipment, furnishings, or other personal property utilized by Tenant
in the operation of Tenant's business, Tenant warrants that any Uniform
Commercial Code financing statement executed by Tenant will upon its face or by
exhibit thereto indicate that such financing statement is applicable only to
personal property of Tenant specifically described in the financing statement,
and that such property is subject to the provisions of Section 30 regarding the
removal of property on the expiration or earlier termination of this Lease. In
no event shall the address of the Building be furnished on the financing
statement without qualifying language as to applicability of the lien

                                     - 16 -
<PAGE>   20
only to personal property of Tenant described in the financing statement. Should
any holder of a security agreement executed by Tenant record or place of record
a financing statement which appears to constitute a lien against any interest of
Landlord, Tenant shall within ten (10) days after the filing of such financing
statement cause (i) copies of the security agreement or other documents to which
the financing statement pertains to be furnished to Landlord to facilitate
Landlord's being in a position to show such lien is not applicable to any
interest of Landlord, and (ii) the holder of the security interest to amend
documents of record so as to clarify that such lien is not applicable to any
interest of Landlord in the Premises.

        20.    INDEMNIFICATION AND EXCULPATION

               20.1 Except to the extent of the responsibility of Landlord
pursuant to Section 20.2 hereof, Tenant agrees to indemnify Landlord, and its
partners and affiliates, and their respective shareholders, directors, officers,
agents, contractors and employees (collectively, "Landlord's Agents"), against,
and to protect, defend, and save them harmless from, all demands, claims, causes
of action, liabilities, losses and judgments, and all reasonable expenses
incurred in investigating or resisting the same (including reasonable attorneys'
fees), for death of or injury to person or damage to property arising out of (i)
any occurrence in, upon or about the Premises during the term of this Lease,
(ii) Tenant's use, occupancy, repairs, maintenance, and improvements of the
Premises and all improvements, fixtures, equipment and personal property
thereon, and (iii) any act or omission of Tenant, its shareholders, directors,
officers, agents, employees, servants, contractors, invitees and subtenants.
Tenant's obligation under this Section 20.1 shall survive the expiration or
earlier termination of the term of this Lease.

               20.2 Landlord agrees to indemnify Tenant and Tenant's
shareholders, directors, officers, agents, and employees (collectively "Tenant's
Agents") against and save them harmless from all demands, claims, causes of
action and judgments, and all reasonable expenses incurred in investigating or
resisting the same (including reasonable attorneys' fees), for death of, or
injury to, any person or damage to property arising from or out of any
occurrence in, upon, or about the Premises during the term of this Lease if
caused by the willful misconduct or gross negligence of Landlord or Landlord's
directors, officers, agents, employees, servants, contractors, invitees and
subtenants, unless caused in part by the willful misconduct or gross negligence
of Tenant or Tenant's Agents. Landlord's obligations under this Section 20.2
shall survive the expiration or earlier termination of the term of this Lease.

               20.3 Notwithstanding any provision of Sections 20.1 and 20.2 to
the contrary, Landlord shall not be liable to Tenant and Tenant assumes all risk
of damage to any fixtures, goods, inventory, merchandise, equipment, records,
research, experiments, animals and other living organisms, computer hardware and
software, leasehold improvements, and other personal property of any nature
whatsoever, and Landlord shall not be liable for injury to Tenant's business or
any loss of income therefrom relative to such damage, unless caused by
Landlord's or Landlord's Agents' willful misconduct or gross negligence.

               20.4 The indemnity obligations of both Landlord and Tenant under
this Section 20 shall be satisfied to the extent of proceeds of applicable
insurance maintained by Tenant to the extent thereof, and thereafter to proceeds
of any applicable insurance maintained


                                     - 17 -
<PAGE>   21
by Landlord; Landlord and Tenant shall be required to satisfy any such
obligation only to the extent it is not satisfied by proceeds of applicable
insurance as set forth above.

               20.5 Security devices and services, if any, while intended to
deter crime may not in given instances prevent theft or other criminal acts and
it is agreed that Landlord shall not be liable for injuries or losses caused by
criminal acts of third parties and the risk that any security device or service
may malfunction or otherwise be circumvented by a criminal is assumed by Tenant.
Tenant shall at Tenant's cost obtain insurance coverages to the extent Tenant
desires protection against such criminal acts.

        21.    INSURANCE - WAIVER OF SUBROGATION.

               21.1 Commencing prior to Tenant's first entry onto the Premises
for purposes of installing any improvements, fixtures or personal property, but
no later than the Term Commencement Date, and continuing at all times during the
term of this Lease, Tenant shall maintain, at Tenant's expense, commercial
general liability insurance, on an occurrence basis, insuring Tenant and
Tenant's agents, employees and independent contractors against all bodily
injury, property damage, personal injury and other covered loss arising out of
the use, occupancy, improvement and maintenance of the Premises and the business
operated by Tenant, or any other occupant, on the Premises. Such insurance shall
have a minimum combined single limit of liability per occurrence of not less
than $4,000,000.00 and a general aggregate limit of $4,000,000.00. Such
insurance shall: (i) name Landlord, and Landlord's lenders if required by such
lenders, and any management company retained to manage the Premises if requested
by Landlord, as additional insureds; (ii) include a broad form contractual
liability endorsement insuring Tenant's indemnity obligations under Section
20.1; (iii) include a products liability coverage endorsement (with limits of
$2,000,000.00 on a "claims made" basis), a boiler and machinery liability
endorsement, and a products completed operations coverage endorsement; (iv)
provide that it is primary coverage and noncontributing with any insurance
maintained by Landlord or Landlord's lenders, which shall be excess insurance
with respect only to losses arising out of Tenant's negligence; and (v) provide
for severability of interests or include a cross-liability endorsement, such
that an act or omission of an insured shall not reduce or avoid coverage of
other insureds.

               21.2 At all times during the term of this Lease, Tenant shall
maintain, at Tenant's expense, "all risk" insurance, including, but not limited
to, coverage against loss or damage by fire, vandalism, and malicious mischief
covering the Building (exclusive of excavations, foundations and footings),
Tenant's Improvements (whether owned by Landlord or Tenant), and all other
improvements and fixtures that may be constructed or installed on the Premises,
in an amount equal to one hundred percent (100%) of the full replacement value
thereof. If any boilers or other pressure vessels or systems are installed on
the Premises, Tenant shall maintain, at Tenant's expense, boiler and machinery
insurance in an amount equal to one hundred percent (100%) of the full
replacement value thereof. At all times during the course of any major
demolition or construction permitted hereunder, or any restoration pursuant to
Articles 22 or 23, Tenant shall maintain, at Tenant's expense, "all risk"
builder's risk insurance, including, but not limited to, coverage against loss
of damage by fire, vandalism and malicious mischief, covering improvements in
place and all material and equipment at the job site furnished 

                                     - 18 -
<PAGE>   22
under contract, in an amount equal to one hundred percent (100%) of the full
replacement value thereof. The insurance described in this Section 21.2 shall:
(i) insure Landlord, and Landlord's lenders if required by such lenders, as
their interests may appear; (ii) contain a Lender's Loss Payable Form (Form 438
BFU or equivalent) in favor of Landlord's lenders and name Landlord, or
Landlord's lender if required by such lender, as the loss payee; (iii) provide
for severability of interests or include a cross-liability endorsement, such
that an act or omission of an insured shall not reduce or avoid coverage of
other insureds; (iv) include a building ordinance endorsement, an agreed amount
endorsement and an inflation endorsement; and (v) provide that it is primary
coverage and noncontributing with any insurance maintained by Landlord or
Landlord's lenders, which shall be excess insurance. The full replacement value
of the Building, Tenant's Improvements and other improvements and fixtures
insured thereunder shall, for the purpose of establishing insurance limits and
premiums only, be determined by the company issuing the insurance policy and
shall be redetermined by said company within six (6) months after completion of
any material alterations or improvements to the Premises and otherwise at
intervals of not more than three (3) years. Tenant shall promptly increase the
amount of the insurance carried pursuant to this Section 21.2 to the amount so
redetermined. The proceeds of the insurance described in this Section shall be
used for the repair, replacement and restoration of the Premises and Tenant's
Improvements and other improvements and fixtures insured thereunder, as further
provided in Article 22; provided, however, if this Lease is terminated after
damage or destruction, the insurance policy or policies, all rights thereunder
and all insurance proceeds shall be assigned to Landlord and Tenant in an
equitable manner taking into consideration the unamortized portion of each
party's contribution toward the cost of the Tenant's Improvements with respect
to which such proceeds have been paid.

               21.3 At all times during the term of this Lease, Tenant shall
maintain, at Tenant's expense, business interruption insurance in order to
insure that the Basic Annual Rent and Operating Expenses provided for hereunder
will be paid for a period of up to one (1) year after any casualty insured
against by all risk policy of insurance described in Section 21.2 above or any
restriction of access to the Premises as a result of such casualty.

               21.4 At all times during the term of this Lease, Tenant shall
maintain, at Tenant's expense, "all risk" insurance against all other personal
property, including trade fixtures, equipment and merchandise, of Tenant or any
subtenant of Tenant that may be occupying the Premises, or any portion thereof,
from time to time, in an amount equal to the full replacement value thereof.

               21.5 At all times during the term of this Lease, Tenant shall
maintain workers' compensation insurance in accordance with California law, and
employers' liability insurance with limits typical for companies similar to
Tenant.

               21.6 All of the policies of insurance referred to in this Article
21 shall be written by companies authorized to do business in California and
rated A+VII or better in Best's Insurance Guide. Each insurer referred to in
this Article 21 shall agree, by endorsement on the applicable policy or by
independent instrument furnished to Landlord, that it will give Landlord, and
Landlord's lenders if required by such lenders, at least ten (10) days' prior
written notice by registered mail before the applicable policy shall be
cancelled for non-payment of premium, and 


                                     - 19 -
<PAGE>   23
thirty (30) days' prior written notice by registered mail before the applicable
policy shall be cancelled or altered in coverage, scope, amount or other
material term for any other reason (although any failure of an insurer to give
notice as provided herein shall not be a breach of this Lease by Tenant). Tenant
shall pay all of the premiums for such insurance and all deductible amounts
provided for thereunder. No policy shall provide for a deductible amount in
excess of $100,000, unless approved in advance in writing by Landlord, which
approval shall not be unreasonably withheld. Tenant shall deliver to Landlord,
and to Landlord's lenders if required by such lenders, copies of the insurance
policies, certified by the insurer, or certificates evidencing such insurance
policies, issued by the insurer, together with evidence of payment of the
required premiums, prior to the required date for commencement of such coverage.
At least thirty (30) days prior to expiration of any such policy, Tenant shall
deliver to Landlord, and Landlord's lenders if required by such lenders, a
certificate evidencing renewal, or a certified copy of a new policy or
certificate evidencing the same, together with evidence of payment of the
required premiums. If Tenant fails to provide to Landlord any such policy or
certificate by the required date for commencement of coverage, or within fifteen
(15) days prior to expiration of any policy, or to pay the premiums therefor
when required, Landlord shall have the right, but not the obligation, to procure
said insurance and pay the premiums therefor. Any premiums paid by Landlord
shall be repaid by Tenant to Landlord with the next due installment of rent, and
failure to repay the same shall have the same consequences as failure to pay any
installment of Rent.

               21.7 If the insurance required pursuant to this Article 21 is
materially less in amount or type of insurance than the insurance typically
carried by owners or tenants of comparable "biotech" properties located in the
UTC/Torrey Pines/Sorrento Valley area of San Diego, California, which are
similar to and operated for similar purposes as the Premises, Landlord may elect
to require Tenant to increase the amount of coverage. Landlord shall notify
Tenant in writing of the specific increase required, and Tenant shall have
thirty (30) days after receipt of Landlord's notice to effect the increase. Any
adjustment pursuant to this Section 21.7 may be made not more often than once
every five (5) years unless otherwise agreed by Landlord and Tenant. In no event
shall Tenant be required to carry earthquake or flood insurance.

               21.8 Tenant may provide the property insurance required under
this Article 21 pursuant to a so-called blanket policy or policies of property
insurance maintained by Tenant; provided, however, that the amount and type of
coverage afforded to the Landlord shall not be reduced or adversely affected
from that which would exist under a separate policy or policies meeting all of
the requirements of this Lease by reason of the use of a blanket policy of
property insurance, and provided further that the requirements of this Article
21 are otherwise satisfied.

               21.9 Landlord and Tenant each hereby waive any and all rights of
recovery against the other or against the officers, directors, partners,
employees, agents, and representatives of the other, on account of loss or
damage to such waiving party's property or the property of others under its
control, to the extent that such loss or damage is caused by or results from
risks insured against under any insurance policy which insures such waiving
party's property at the time of such loss or damage, which waiver shall continue
in effect as long as the parties' respective insurers permit such waiver under
the terms of their respective insurance policies or otherwise in writing. Any
termination of such waiver shall be by written notice as hereinafter 


                                     - 20 -
<PAGE>   24
set forth. Prior to obtaining policies of insurance required or permitted under
this Lease, Landlord and Tenant shall give notice to the insurers that the
foregoing mutual waiver is contained in this Lease, and each party shall use its
best efforts to cause such insurer to approve such waiver in writing and to
cause each insurance policy obtained by it to provide that the insurer waives
all right of recovery by way of subrogation against the other party. If such
written approval of such waiver of subrogation cannot be obtained from any
insurer or is obtainable only upon payment of an additional premium which the
party seeking to obtain the policy reasonably determines to be commercially
unreasonable, the party seeking to obtain such policy shall notify the other
thereof, and the latter shall have twenty (20) days thereafter to either: (i)
identify other insurance companies reasonably satisfactory to the other party
that will provide the written approval and waiver of subrogation; or (ii) agree
to pay such additional premium. If neither (i) nor (ii) are done, the mutual
waiver set forth above shall not be operative, and the party seeking to obtain
the policy shall be relieved of the obligation to obtain the insurer's written
approval and waiver of subrogation with respect to such policy during such time
as such policy is not obtainable or is obtainable only upon payment of a
commercially unreasonable additional premium as described above. If such
policies shall at any subsequent time be obtainable or obtainable upon payment
of a commercially reasonable additional premium, neither party shall be
subsequently liable for failure to obtain such insurance until a reasonable time
after notification thereof by the other party. If the release of either Landlord
or Tenant, as set forth in the first sentence of this Section 21.9, shall
contravene any law with respect to exculpatory agreements, the liability of the
party in question shall be deemed not released but shall be secondary to the
other's insurer.

        22.    DAMAGE OR DESTRUCTION

               22.1 Tenant shall give written notice to Landlord immediately
upon any damages to or destruction of the Premises if the loss sustained exceeds
Ten Thousand Dollars ($10,000). In the event of damage to or destruction of all
or any portion of the Premises or the improvements and fixtures thereon
(collectively, "improvements") arising from a risk covered by the insurance
described in Section 21.2, Tenant shall within a reasonable time commence and
proceed diligently to repair, reconstruct and restore (collectively, "restore")
such improvements to substantially the same condition as they were in
immediately prior to the casualty, whether or not the insurance proceeds are
sufficient to cover the actual cost of restoration. Except as expressly set
forth below, this Lease shall continue in full force and effect, notwithstanding
such damage or destruction.

               22.2 In the event of any damage to or destruction of all or any
portion of the improvements arising from a risk which is not covered by the
insurance described in Section 21.2, Tenant shall within a reasonable time
commence and proceed diligently to restore the improvements to substantially the
same condition as they were in immediately prior to the casualty, in which case
this Lease shall continue in full force and effect. In satisfying its
obligations under this Article 22, Tenant shall not be required to restore the
Premises with improvements identical to those which were damaged or destroyed;
rather, with the consent of Landlord, which consent will not be unreasonably
withheld, Tenant may restore the damage or destruction with improvements
reasonably equivalent or of reasonably equivalent value to those


                                     - 21 -
<PAGE>   25
damaged or destroyed. Nothing in this subsection, however, shall be construed to
relieve Tenant of any other obligations under this Lease, including the
obligation to pay Rent.

               22.3 In the event of damage, destruction and/or restoration as
herein provided, there shall be no abatement of Rent, and Tenant shall not be
entitled to any compensation or damages occasioned by any such damage,
destruction or restoration.

               22.4 Notwithstanding anything to the contrary contained in this
Article, should Tenant be delayed or prevented form completing the restoration
of the improvements after the occurrence of such damage or destruction by reason
of acts of God, war, government restrictions, inability to procure the necessary
labor or materials, strikes, or other causes beyond the control of Tenant (but
excluding economic conditions or financial inability to perform), the time for
Tenant to commence or complete restoration shall be extended for the time
reasonably required as a result of such event.

               22.5 If insured casualty occurs and the total amount of loss does
not exceed Ten Thousand Dollars ($10,000), Tenant shall make the loss adjustment
with the insurance company insuring the loss, and the proceeds shall be paid
directly to Tenant for the sole purpose of completing the restoration required
pursuant to this Article 22. If the total amount of loss exceeds Ten Thousand
Dollars ($10,000), Tenant shall make the loss adjustment with the insurance
company, which adjustment shall be subject to the approval of Landlord, which
approval shall not be unreasonably withheld, and the proceeds shall be
immediately deposited with an institutional lender or other entity ("Insurance
Trustee") designated by Tenant and approved by Landlord, which approval shall
not be unreasonably withheld, who shall agree to hold said proceeds in trust and
to disburse said proceeds in accordance with the provisions of this Section. If
the improvements are damaged or destroyed as a result of a risk not covered by
insurance as described in Section 22.2, Tenant shall deposit with the Insurance
Trustee its contribution towards the cost of restoration, or in lieu thereof
shall provide financial assurances satisfactory to Landlord of its ability and
willingness to pay such contribution when required. Restoration work shall not
be commenced until funds sufficient to cover the estimated cost of restoration
have been deposited with the Insurance Trustee. The Insurance Trustee shall
disburse amounts deposited with it to pay the cost of restoration, in
installments as construction progresses, upon presentation of certificates
executed by the architect or engineer retained by Tenant verifying the amount
due, on terms and conditions approved by Landlord and Landlord's lender prior to
commencement of work. A ten percent (10%) retainage shall be reserved from
payments due to the contractor, which retainage shall be paid upon completion of
restoration, payment of all costs, expiration of all applicable liens, and
delivery of evidence that the Premises are free from all mechanics' and
materialmen's liens and lienable claims. Landlord, and Landlord's lenders if
required by such lenders, shall have the right to approve requests for
reimbursement prior to payment, which approval shall not be unreasonably
withheld. Landlord shall have the right to engage an architect or engineer to
review and approve requests for disbursement, and reasonable expenses incurred
by such party shall be paid by the Insurance Trustee out of the funds deposited
with the Insurance Trustee. If, at any time during the course of restoration,
the funds held by the Insurance Trustee are not sufficient to pay the actual
costs of restoration, Tenant shall deposit the amount of the deficiency with the
Insurance Trustee within twenty (20) days after receipt of a written request
from the Insurance Trustee. After restoration has been 


                                     - 22 -
<PAGE>   26
completed and final payment has been made to Tenant's contractor, within fifteen
(15) days after demand by either party, the Insurance Trustee shall pay
undisbursed funds remaining thereafter to Tenant. All actual costs and charges
of the Insurance Trustee shall be paid by Tenant. Each party shall promptly
execute all documents and perform all acts reasonably required by the Insurance
Trustee to perform its obligations under this Section.

               22.6 If restoration is required pursuant to this Article, Tenant,
at its expense, shall prepare final plans and specifications and working
drawings for the work in compliance with all applicable laws. The plans and
specifications and working drawings shall be subject to the approval of
Landlord, which approval shall not be unreasonably withheld, within thirty (30)
days after receipt and the approval of Landlord's lenders, which approval shall
not be unreasonably withheld, if required by such lenders. Tenant shall submit
the plans and specifications as soon as reasonably practicable, but in no event
later than one hundred twenty (120) days after the casualty. Tenant shall
commence the restoration within thirty (30) days after issuance of all necessary
permits and approvals and shall continue the work diligently to completion
thereafter. The provisions of Article 17 shall apply to any restoration work
under this Article as if the restoration was an alteration, addition or
improvement thereunder.

               22.7 Tenant waives the provisions of Civil Code Section 1932(2)
and 1933(4) or any similar statute now existing or hereafter adopted governing
destruction of the Premises, so that the parties' rights and obligations in the
event of damage or destruction shall be governed by the provisions of this
Lease.

        23.    EMINENT DOMAIN

               23.1 In the event the whole of the Premises shall be taken for
any public or quasi-public purpose by any lawful power or authority by exercise
of the right of appropriation, condemnation or eminent domain, or sold to
prevent such taking, Tenant or Landlord may terminate this Lease effective as of
the date possession is required to be surrendered to said authority.

               23.2 In the event of a partial taking of the Premises for any
public or quasi-public purpose by any lawful power or authority by exercise of
right of appropriation, condemnation, or eminent domain, or sold to prevent such
taking, then Landlord may elect to terminate this Lease if such taking is of a
material nature such as to make it uneconomical to continue use of the
unappropriated portions for the purposes for which they were intended, and
Tenant may elect to terminate this Lease if such taking is of material detriment
to, and substantially interferes with, Tenant's use and occupancy of the
Premises, including but not limited to materially affecting Tenant's parking or
Tenant's ingress and egress from the Premises, unless Landlord provides
reasonable alternatives thereto. In no event shall this Lease be terminated when
such a partial taking does not have a material adverse effect upon Landlord or
Tenant or both. Termination by either party pursuant to this section shall be
effective as of the date possession is required to be surrendered to said
authority.

               23.3 If upon any taking of the nature described in this Article
23 this Lease continues in effect, then Tenant shall promptly proceed to restore
the remaining portion of the 


                                     - 23 -
<PAGE>   27
Premises, and all improvements and fixtures located thereon, to substantially
their same condition prior to such partial taking; provided, however, Tenant's
obligation hereunder shall be limited to the amount of the condemnation
proceeds. Basic Annual Rent shall be abated proportionately on the basis of the
rental value of the Premises, including improvements and fixtures, as restored
after such taking compared to the rental value of the Premises prior to such
taking.

        If the cost of restoration does not exceed Ten Thousand Dollars
($10,000), any award for the taking shall be paid directly to Tenant for the
sole purpose of completing the restoration required pursuant to this Article 23.
If the cost of restoration exceeds Ten Thousand Dollars ($10,000), the award
shall be immediately deposited with an institutional lender or other entity
("Condemnation Trustee") designated by Landlord and approved by Tenant, which
approval shall not be unreasonably withheld, who shall agree to hold said
proceeds in trust and to disburse said proceeds in accordance with the
provisions of this Section. The Condemnation Trustee shall disburse amounts
deposited with it to pay the cost of restoration, in installments as
construction progresses, upon presentation of certificates executed by the
architect or engineer retained by Tenant verifying the amount due, on terms and
conditions approved by Landlord and Landlord's lenders prior to commencement of
work. A ten percent (10%) retainage shall be reserved from payments due to the
contractor, which retainage shall be paid upon completion of restoration,
payment of all costs, expiration of all applicable liens, and delivery of
evidence that the Premises are free from all mechanics' and materialmen's liens
and lienable claims. Landlord, and Landlord's lenders if required by such
lenders, shall have the right to approve requests for reimbursement prior to
payment, which approval shall not be unreasonably withheld. Landlord shall have
the right to engage an architect or engineer to review and approve requests for
disbursement, and reasonable expenses incurred by such party shall be paid by
the Condemnation Trustee out of the funds deposited with the Condemnation
Trustee. All actual costs and charges of the Condemnation Trustee shall be paid
out of the funds deposited. Each party shall promptly execute all documents and
perform all acts reasonably required by the Condemnation Trustee to perform its
obligations under this Section.

        If restoration is required pursuant to this Article, Tenant, using
proceeds of the award, shall prepare final plans and specifications and working
drawings for the work in compliance with all applicable laws. The plans and
specifications and working drawings shall be subject to the approval of Landlord
within thirty (30) days after receipt, which approval shall not be unreasonably
withheld. Tenant shall submit the plans and specifications as soon as reasonably
practicable, but in no event later than one hundred twenty (120) days after the
taking, unless due to delays beyond Tenant's control. Subject to unavoidable
delays, Tenant shall commence the restoration within thirty (30) days after
issuance of all necessary permits and approvals and shall continue the work
diligently to completion thereafter. The provisions of Article 17 shall apply to
any restoration work under this Article as if the restoration was an alteration,
addition or improvement under Article 17.

               23.4 If upon any taking of the nature described in this Article
23 this Lease does not continue in effect, or in the event final payment has
been made to Tenant's contractor under the preceding Section 23.3 and the
Condemnation Trustee holds additional funds from the award, any award shall be
distributed to Landlord and Tenant pro rata according to their interests taken.

                                     - 24 -
<PAGE>   28
        24.    DEFAULTS AND REMEDIES

               24.1 Late payment by Tenant to Landlord of Rent and other sums
due will cause Landlord to incur costs not contemplated by this Lease, the exact
amount of which will be extremely difficult and impracticable to ascertain. Such
costs include, but are not limited to, processing and accounting charges and
late charges which may be imposed on Landlord by the terms of any mortgage or
trust deed covering the Premises. Therefore, if any installment of Rent due from
Tenant is not received by Landlord within ten (10) days of the date such payment
is due, Tenant shall pay to Landlord an additional sum of five percent (5%) of
the overdue rent as a late charge. The parties agree that this late charge
represents a fair and reasonable estimate of the costs that Landlord will incur
by reason of late payment by Tenant. In addition to the late charge, Rent not
paid within thirty (30) days of the date such payment is due shall bear interest
from thirty (30) days after the date due until paid at the lesser of (i) ten
percent (10%) per annum or (ii) the maximum rate permitted by law.

               24.2 No payment by Tenant or receipt by Landlord of a lesser
amount than the rent payment herein stipulated shall be deemed to be other than
on account of the rent, nor shall any endorsement or statement on any check or
any letter accompanying any check or payment as rent be deemed an accord and
satisfaction, and Landlord may accept such check or payment without prejudice to
Landlord's right to recover the balance of such rent or pursue any other remedy
provided. If at any time a dispute shall arise as to any amount or sum of money
to be paid by Tenant to Landlord, Tenant shall have the right to make payment
"under protest" and such payment shall not be regarded as a voluntary payment,
and there shall survive the right on the part of Tenant to institute suit for
recovery of the payment paid under protest.

               24.3 If Tenant fails to pay any sum of money (other than Basic
Annual Rent) required to be paid by it hereunder, or shall fail to perform any
other act on its part to be performed hereunder, Landlord may, without waiving
or releasing Tenant from any obligations of Tenant, but shall not be obligated
to, make such payment or perform such act; provided, that such failure by Tenant
continued for ten (10) days after written notice from Landlord demanding
performance by Tenant was delivered to Tenant, or that such failure by Tenant
unreasonably interfered with the use or efficient operation of the Premises, or
resulted or could have resulted in a violation of law or the cancellation of an
insurance policy maintained by Landlord. All sums so paid or incurred by
Landlord, together with interest thereon, from the date such sums were paid or
incurred, at the annual rate equal to ten percent (10%) per annum or highest
rate permitted by law, whichever is less, shall be payable to Landlord on demand
as Additional Rent.

               24.4 The occurrence of any one or more of the following events
shall constitute a default hereunder by Tenant:

                (a) The failure by Tenant to make any payment of Rent, as and
when due, where such failure shall continue for a period of five (5) days after
written notice thereof from Landlord to Tenant. Such notice shall be in lieu of,
and not in addition to, any notice required under California Code of Civil
Procedure Section 1161;

                                     - 25 -
<PAGE>   29
                (b) The failure by Tenant to observe or perform any obligation
other than described in Section 24.4(a) to be performed by Tenant, where such
failure shall continue for a period of thirty (30) days after written notice
thereof from Landlord to Tenant; provided, however, that if the nature of
Tenant's default is such that more than thirty (30) days are reasonably required
to cure the default, then Tenant shall not be deemed to be in default if Tenant
shall commence such cure within said thirty (30) day period and thereafter
diligently prosecute the same to completion. Such notice shall be in lieu of,
and not in addition to, any notice required under California Code of Civil
Procedure Section 1161;

                (c) Tenant makes an assignment for the benefit of creditors;

                (d) A receiver, trustee or custodian is appointed to, or does,
take title, possession or control of all, or substantially all, of Tenant's
assets;

                (e) An order for relief is entered against Tenant pursuant to a
voluntary or involuntary proceeding commenced under any chapter of the
Bankruptcy Code;

                (f) Any involuntary petition is filed against the Tenant under
any chapter of the Bankruptcy Code and is not dismissed within ninety (90) days;
or

                (g) Tenant's interest in this Lease is attached, executed upon,
or otherwise judicially seized and such action is not released within ninety
(90) days of the action.

                Notices given under this Section shall specify the alleged
default and shall demand that Tenant perform the provisions of this Lease or pay
the Rent that is in arrears, as the case may be, within the applicable period of
time, or quit the Premises. No such notice shall be deemed a forfeiture or a
termination of this Lease unless Landlord elects otherwise in such notice, and
in no event shall a forfeiture or termination occur without such written notice.

               24.5 In the event of a default by Tenant, and at any time
thereafter, and without limiting Landlord in the exercise of any right or remedy
which Landlord may have, Landlord shall be entitled to terminate Tenant's right
to possession of the Premises by any lawful means, in which case this Lease
shall terminate and Tenant shall immediately surrender possession of the
Premises to Landlord. In such event Landlord shall have the immediate right to
re-enter and remove all persons and property, and such property may be removed
and stored in a public warehouse or elsewhere at the cost of, and for the
account of Tenant, all without service of notice and without being deemed guilty
of trespass, or becoming liable for any loss or damage which may be occasioned
thereby. In the event that Landlord shall elect to so terminate this Lease, then
Landlord shall be entitled to recover from Tenant all damages incurred by
Landlord by reason of Tenant's default, including:

                (a) The worth at the time of award of any unpaid Rent which had
been earned at the time of such termination; plus

                                     - 26 -
<PAGE>   30
                (b) The worth at the time of award of the amount by which the
unpaid Rent which would have been earned after termination until the time of
award exceeds the amount of such rental loss which Tenant proves could have been
reasonably avoided; plus

                (c) The worth at the time of award of the amount by which the
unpaid Rent for the balance of the term after the time of award exceeds the
amount of such rental loss which Tenant proves could have been reasonably
avoided; plus

                (d) Any other amount necessary to compensate Landlord for all
the detriment proximately caused by Tenant's failure to perform its obligation
under this Lease or which in the ordinary course of things would be likely to
result therefrom, including, but not limited to, the cost of restoring the
Premises to the condition required under the terms of this Lease; plus

                (e) At Landlord's election, such other amounts in addition to or
in lieu of the foregoing as may be permitted from time to time by applicable
law.

                As used in Subsections (a), (b) and (c), the "time of award"
shall mean the date upon which the judgment in any action brought by Landlord
against Tenant by reason of such default is entered or such earlier date as the
court may determined. As used in Subsections (a) and (b), the "worth at the time
of award" shall be computed by allowing interest at the rate specified in
Section 24.1. As used in Subsection (c) above, the "worth at the time of award"
shall be computed by taking the present value of such amount using the discount
rate of the Federal Reserve Bank of San Francisco at the time of award plus one
percentage point.

               24.6 In the event of a default by Tenant, and if Landlord does
not elect to terminate this Lease as provided in Section 24.5 or otherwise
terminate Tenant's right to possession of the Premises, Landlord shall have the
remedy described in Section 1951.4 of the Civil Code. Landlord may continue this
Lease in effect for so long as Landlord does not terminate Tenant's right to
possession of the Premises, and may enforce all of its rights and remedies under
the Lease, including the right from time to time to recover Rent as it becomes
due under the Lease. At any time thereafter, Landlord may elect to terminate
this Lease and to recover damages to which Landlord is entitled.

               24.7 Notwithstanding anything herein to the contrary, Landlord's
reentry to perform acts of maintenance or preservation of, or in connection with
efforts to relet, the Premises, or any portion thereof, or the appointment of a
receiver upon Landlord's initiative to protect Landlord's interest under this
Lease, shall not terminate Tenant's right to possession of the Premises or any
portion thereof and, until Landlord does elect to terminate this Lease, this
Lease shall continue in full force and Landlord may pursue all its remedies
hereunder, including, without limitation, the right to recover from Tenant as
they become due hereunder all Rent and other charges required to be paid by
Tenant under the terms of this Lease.

               24.8 All rights, options, and remedies of Landlord contained in
this Lease shall be construed and held to be nonexclusive and cumulative.
Landlord shall have the right to pursue any one or all of such remedies or any
other remedy or relief which may be provided by


                                     - 27 -
<PAGE>   31
law, whether or not stated in this Lease. No waiver of any default of Tenant
hereunder shall be implied from any acceptance by Landlord of any rent or other
payments due hereunder or by any omission by Landlord to take any action on
account of such default if such default persists or is repeated, and no express
waiver shall affect defaults other than as specified in said waiver.

               24.9 Termination of this Lease or Tenant's right to possession by
Landlord shall not relieve Tenant from any liability to Landlord which has
theretofore accrued or shall arise based upon events which occurred prior to the
last to occur of (i) the date of Lease termination or (ii) the date possession
of Premises is surrendered.

               24.10 Landlord shall not be in default unless Landlord fails to
perform obligations required of Landlord within a reasonable time, but in no
event later than thirty (30) days after written notice by Tenant specifying
wherein Landlord has failed to perform such obligation; provided, however, that
if the nature of Landlord's obligation is such that more than thirty (30) days
are required for performance, then Landlord shall not be in default if Landlord
commences performance within such thirty (30) day period and thereafter
diligently prosecutes the same to completion.

               24.11 In the event of any default on the part of Landlord, Tenant
will give notice by registered or certified mail to any beneficiary of a deed of
trust or mortgagee of a mortgage covering the Premises whose address shall have
been furnished and shall offer such beneficiary and/or mortgagee a reasonable
opportunity to cure the default, including time to obtain possession of the
Premises by power of sale or a judicial action if such should prove necessary to
effect a cure.

        25.    ASSIGNMENT OR SUBLETTING

               25.1 Except as hereinafter provided, Tenant shall not, either
voluntarily or by operation of law, sell, hypothecate or transfer this Lease, or
sublet the Premises or any part thereof, or permit or suffer the Premises or any
part thereof to be used or occupied as work space, storage space, concession or
otherwise by anyone other than Tenant or Tenant's employees, without the prior
written consent of Landlord in each instance, which consent shall not be
unreasonably withheld or delayed.

               25.2 If Tenant desires to assign this Lease to any entity into
which Tenant is merged, with which Tenant is consolidated, or which acquires all
or substantially all of the assets of Tenant, provided that the assignee first
executes, acknowledges and delivers to Landlord an agreement whereby the
assignee agrees to be bound by all of the covenants and agreements in this Lease
arising after the effective date of the transfer, then Landlord upon receipt of
proof of foregoing, will consent to the assignment.

               25.3 In the event Tenant desires to assign, sublease, hypothecate
or otherwise transfer this Lease or sublet the Premises to an assignee other
than one set forth in Section 25.2, then at least ten (10) days, but not more
than forty-five (45) days, prior to the date when Tenant desires the assignment
or sublease to be effective (the "Assignment Date"), Tenant shall give Landlord
a notice (the "Assignment Notice") which shall set forth the name, address and
business 

                                     - 28 -
<PAGE>   32
of the proposed assignee or sublessee, information (including references and
financial statements) concerning the reputation and financial ability of the
proposed assignee or sublessee, the Assignment Date, any ownership or commercial
relationship between Tenant and the proposed assignee or sublessee, and the
consideration and all other material terms and conditions of the proposed
assignment or sublease, all in such detail as Landlord shall reasonably require.

               25.4 Landlord in making its determination as to whether consent
should be given to a proposed assignment or sublease, may give consideration to
the reputation of a proposed successor, the financial strength of such successor
(notwithstanding the assignor remaining liable for Tenant's performance), and
any use which such successor proposes to make of the Premises. If Landlord fails
to deliver written notice of its determination to Tenant within thirty (30) days
following receipt of the Assignment Notice and the information required under
Section 25.3, Landlord shall be deemed to have approved the request. As a
condition to any assignment or sublease to which Landlord has given consent, any
such assignee or sublessee must execute, acknowledge and deliver to Landlord an
agreement whereby the assignee or sublessee agrees to be bound by all of the
covenants and agreements in this Lease.

               25.5 Any sale, assignment, hypothecation or transfer of this
Lease or subletting of Premises that is not in compliance with the provisions of
this Article 25 shall be void and shall, at the option of Landlord, terminate
this Lease.

               25.6 The consent by Landlord to an assignment or subletting shall
not relieve Tenant or any assignee of this Lease or sublessee of the Premises
from obtaining the consent of Landlord to any further assignment or subletting
or as releasing Tenant or any assignee or sublessee of Tenant from full and
primary liability.

               25.7 If Tenant shall sublet the Premises or any part thereof
Tenant hereby immediately and irrevocably assigns to Landlord, as security for
Tenant's obligations under this Lease, all rent from any subletting of all or a
part of the Premises, and Landlord as assignee of Tenant, or a receiver for
Tenant appointed on Landlord's application, may collect such rent and apply it
toward Tenant's obligations under this Lease; except that, until the occurrence
of an act of default by Tenant, Tenant shall have the right to collect such
rent.

               25.8 Notwithstanding any subletting or assignment Tenant shall
remain fully and primarily liable for the payment of all Rent and other sums
due, or to become due hereunder, and for the full performance of all other
terms, conditions, and covenants to be kept and performed by Tenant. The
acceptance of rent or any other sum due hereunder, or the acceptance of
performance of any other term, covenant, or condition hereof, from any other
person or entity shall not be deemed to be a waiver of any of the provisions of
this Lease or a consent to any subletting or assignment of the Premises.
Landlord shall not withhold consent to an assignment back to the original Tenant
hereunder from a subsequent assignee.

               25.9 Any sublease of the Premises shall be subject and
subordinate to the provisions of this Lease, shall not extend beyond the term of
this Lease, and shall provide that the sublessee shall attorn to Landlord, at
Landlord's sole option, in the event of the termination of this Lease. Landlord
and any lender shall upon Tenant's request provide any subtenant of the


                                     - 29 -
<PAGE>   33
entirety of the Premises with a recognition and nondisturbance agreement in the
form set forth in Article 35 hereof on the condition that the sublessee agrees
to attorn to Landlord on exactly the same terms and conditions as this Lease.

        26.    ATTORNEY'S FEES

               26.1 If either party becomes a party to any action or proceeding
concerning this Lease or the Premises, or any part thereof, by reason of any act
or omission of the other party or its authorized representatives, and not by any
act or omission of the party that becomes a party to that litigation or any act
or omission of its authorized representatives, the party that causes the other
party to become involved in the litigation shall be liable to that party for
reasonable attorneys' fees, expert witness fees, and court costs incurred by it
in the litigation.

               26.2 If either party commences an action or proceeding against
the other party arising out of or in connection with this Lease, the prevailing
party shall be entitled to have and recover from the other party reasonable
attorneys' fees, expert witness fees and costs of suit.

        27.    BANKRUPTCY

               27.1 In the event a debtor or trustee under the Bankruptcy Code,
or other person with similar rights, duties and powers under any other law,
proposes to cure any default under this Lease or to assume or assign this Lease,
and is obliged to provide adequate assurance to Landlord that (i) a default will
be cured, (ii) Landlord will be compensated for its damages arising from any
breach of this Lease, or (iii) future performance under this Lease will occur,
then adequate assurance shall include any or all of the following, as determined
by the Bankruptcy Court:

                (a) Those acts specified in the Bankruptcy Code or other law as
included within the meaning of adequate assurance;

                (b) A cash payment to compensate Landlord for any monetary
defaults or damages arising from a breach of this Lease;

                (c) The credit worthiness and desirability, as a tenant, of the
person assuming this Lease or receiving an assignment of this Lease, at least
equal to Landlord's customary and usual credit worthiness requirements and
desirability standards in effect at the time of the assumption or assignment, as
determined by the Bankruptcy Court; and

                (d) The assumption or assignment of all of Tenant's interest and
obligations under this Lease.

 .       28.    DEFINITION OF LANDLORD

               28.1 The term "Landlord" as used in this Lease, so far as
covenants or obligations on the part of Landlord are concerned, shall be limited
to mean and include only Landlord or the successor-in-interest of Landlord under
this Lease at the time in question. In the


                                     - 30 -
<PAGE>   34
event of any transfer, assignment or conveyance of Landlord's title or
leasehold, the Landlord herein named (and in case of any subsequent transfers or
conveyances, the then grantor and any prior grantors) shall be automatically
freed and relieved from and after the date of such transfer, assignment or
conveyance of all liability for the performance of any covenants or obligations
contained in this Lease thereafter to be performed by Landlord and, without
further agreement, the transferee of such title or leasehold shall be deemed to
have assumed and agreed to observe and perform any and all obligations of
Landlord hereunder, during its ownership of the Premises. Landlord may transfer
its interest in the Premises or this Lease without the consent of Tenant and
such transfer or subsequent transfer shall not be deemed a violation on the part
of Landlord or the then grantor of any of the terms or conditions of this Lease.

               28.2 Notwithstanding the foregoing, the term "Landlord" shall
include the Landlord herein named (Science Park Center LLC, even if its interest
is assigned to a successor) with regard to (i) responsibility for construction
of the Project Work pursuant to Sections 4.1 hereof, (ii) the warranties made by
Landlord under Section 14.4 to the extent thereof, (iii) responsibility for
covenants and representations made by Landlord in Section 39.8 hereof, (iv) the
obligation to deliver the Premises lien-free pursuant to Section 35.4, and (v)
the completion of punch-list items pursuant to Section 6.3 of the Work Letter.

        29.    ESTOPPEL CERTIFICATE

               29.1 Each party shall, within fifteen (15) days of written notice
from the other party, execute, acknowledge and deliver to the other party a
statement in writing on a form reasonably requested by a proposed lender,
purchaser, assignee or subtenant (i) certifying that this Lease is unmodified
and in full force and effect (or, if modified, stating the nature of such
modification and certifying that this Lease as so modified is in full force and
effect) and the dates to which the rental and other charges are paid in advance,
if any, (ii) acknowledging that there are not, to each party's knowledge, any
uncured defaults on the part of Landlord or Tenant hereunder (or specifying such
defaults if any are claimed) and (iii) setting forth such further information
with respect to this Lease or the Premises as may be reasonably requested
thereon. Any such statement may be relied upon by any prospective lender,
purchaser, assignee or subtenant of all or any portion of the Premises.

        30.    REMOVAL OF PROPERTY

               30.1 Except as provided below, all fixtures and personal property
owned by Tenant shall be and remain the property of Tenant, and may be removed
by Tenant at the expiration or earlier termination of the term of this Lease.

               30.2 The Building and Improvements, and all fixtures and personal
property owned by Landlord, shall be and remain the property of Landlord, and
shall, upon the expiration or earlier termination of this Lease, remain upon and
be surrendered with the Premises as a part thereof. Except as provided below,
all other improvements, additions, alterations, and decorations attached to or
built into the Premises, including (without limiting the generality of the
foregoing) all wallcoverings, built-in cabinet work and paneling, shall, unless
Landlord elects otherwise, 

                                     - 31 -
<PAGE>   35
become the property of Landlord upon the expiration or earlier termination of
this Lease, and shall remain upon and be surrendered with the Premises as a part
thereof.

               30.3 Notwithstanding Sections 30.1 and 30.2 hereof, Tenant may
not remove any property if such removal would cause material damage to the
Premises, unless such damages can be and is repaired by Tenant. Furthermore,
Tenant shall repair any damage to the Premises caused by Tenant's removal of any
such property, and shall, prior to the expiration or earlier termination of this
Lease, restore and return the Premises to the condition they were in when first
occupied by Tenant, reasonable wear and tear excepted. At a minimum, even if
they are determined to be fixtures or personal property owned by Tenant, Tenant
shall leave in place and repair any damage to the interior floors, walls and
ceilings of the Premises. The provisions of Article 17 shall apply to any
restoration work under this Article as if the restoration was an alteration,
addition or improvement thereunder. Should Tenant require any period beyond the
expiration or earlier termination of the Lease to complete such restoration,
Tenant shall be a tenant at sufferance subject to the provisions of Section 12.2
hereof.

               30.4 If Tenant shall fail to remove any fixtures or personal
property which it is entitled to remove under this Article 30 from the Premises
prior to termination of this Lease, then Landlord may dispose of the property
under the provisions of Section 1980 et seq. of the California Civil Code, as
such provisions may be modified from time to time, or under any other applicable
provisions of California law.

        31.    LIMITATION OF LANDLORD'S LIABILITY

               31.1 If Landlord is in default of this Lease, and as a
consequence, Tenant recovers a money judgment against Landlord, the judgment
shall be satisfied only out of the proceeds of sale received on execution of the
judgment and levy against the right, title, and interest of Landlord in the
Premises, and out of rent or other income from the Premises receivable by
Landlord or out of the consideration received by Landlord from the sale or other
disposition of all or any part of Landlord's right, title, and interest in the
Premises.

               31.2 Neither Landlord nor Landlord's Agents shall be personally
liable for any deficiency except to the extent liability is based upon willful
and intentional misconduct. If Landlord is a partnership or joint venture, the
partners of such partnership shall not be personally liable and no partner of
Landlord shall be sued or named as a party in any suit or action, or service of
process be made against any partner of Landlord, except as may be necessary to
secure jurisdiction of the partnership or joint venture or to the extent
liability is caused by willful and intentional misconduct. If Landlord is a
corporation, the shareholders, directors, officers, employees, and/or agents of
such corporation shall not be personally liable and no shareholder, director,
officer, employee, or agent of Landlord shall be sued or named as a party in any
suit or action, or service of process be made against any shareholder, director,
officer, employee, or agent of Landlord, except as may be necessary to secure
jurisdiction of the corporation. If Landlord is a limited liability company, the
members, managers, officers, employees, and/or agents of such limited liability
company shall not be personally liable and no member, manager, officer,
employee, or agent of Landlord shall be sued or named as a party in any suit or
action, or service of process be made against any member, manager, officer,
employee, or agent of

                                     - 32 -
<PAGE>   36
Landlord, except as may be necessary to secure jurisdiction of the corporation.
No partner, shareholder, director, member, manager, employee, or agent of
Landlord shall be required to answer or otherwise plead to any service of
process and no judgment will be taken or writ of execution levied against any
partner, shareholder, director, member, manager, employee, or agent of Landlord.

               31.3 Each of the covenants and agreements of this Article 31
shall be applicable to any covenant or agreement either expressly contained in
this Lease or imposed by statute or by common law.

               31.4 Notwithstanding the foregoing, the Landlord herein named
(Science Park Center LLC) shall remain liable for (i) responsibility for
construction of the Project Work pursuant to Sections 4.1 hereof, (ii) the
warranties made by Landlord under Section 14.4 to the extent thereof, (iii)
responsibility for covenants and representations made by Landlord in Section
39.8 hereof, (iv) the obligation to deliver the Premises lien-free pursuant to
Section 35.4, and (v) the completion of punch-list items pursuant to Section 6.3
of the Work Letter.

        32.    CONTROL BY LANDLORD

               32.1 Landlord reserves full control over the Premises to the
extent not inconsistent with Tenant's quiet enjoyment and use of Premises. This
reservation includes rights granted pursuant to the Project Documents and the
right to maintain or establish ownership of the Building or portions thereof
separate from fee title to the land upon which it rests.

               32.2 Tenant shall, should Landlord so request, promptly join with
Landlord in execution of such documents as may be appropriate to assist Landlord
to implement any such action provided Tenant need not execute any document which
is of a nature wherein liability is created in Tenant or if by reason of the
terms of such document Tenant will be deprived of the quiet enjoyment and use of
the Premises as granted by this Lease.

        33.    QUIET ENJOYMENT

               33.1 So long as Tenant is not in default, Landlord covenants that
Landlord or anyone acting through or under Landlord will not disturb Tenant's
occupancy of the Premises except as permitted by the provisions of this Lease.

        34.    QUITCLAIM DEED

               34.1 Tenant shall execute and deliver to Landlord on the
expiration or termination of this Lease, immediately on Landlord's request, a
quitclaim deed to the Premises or other document in recordable form suitable to
evidence of record termination of this Lease and the right of first refusal and
option contained herein.

                                     - 33 -
<PAGE>   37
        35.    SUBORDINATION AND ATTORNMENT

               35.1 Unless the mortgagee or beneficiary elects otherwise at any
time prior to or following a default by Tenant, this Lease shall be subject to
and subordinate to the lien of any mortgage or deed of trust now or hereafter in
force against the Premises or any portion thereof, and to all advances made or
hereafter to be made upon the security thereof without the necessity of the
execution and delivery of any further instruments on the part of Tenant to
effectuate such subordination, provided that the lienholder, beneficiary, or
mortgagee has previously executed and delivered to Tenant a non-disturbance,
attornment, and subordination agreement in such form as the lienholder,
beneficiary, or mortgagee may reasonably request and is approved by Tenant,
which approval will not be unreasonably withheld, setting forth that so long as
Tenant is not in default hereunder, Landlord's and Tenant's rights and
obligations hereunder shall remain in force and Tenant's right to possession
shall be upheld.

               35.2 Notwithstanding the foregoing, Tenant shall execute and
deliver upon demand such further instrument or instruments evidencing such
subordination of this Lease to the lien of any such mortgage or deed of trust as
may be required by Landlord and in a form reasonably satisfactory to Tenant,
provided that the lienholder, beneficiary, or mortgagee has previously executed
and delivered to Tenant a non-disturbance agreement in recordable form. However,
if any such mortgagee or beneficiary so elects at any time prior to or following
a default by Tenant, this Lease shall be deemed prior in lien to any such
mortgage or deed of trust regardless of date and Tenant will execute a statement
in writing to such effect at Landlord's request in a form reasonably
satisfactory to Tenant.

               35.3 In the event any proceedings are brought for foreclosure, or
in the event of the exercise of the power of sale under any mortgage or deed of
trust made by the Landlord covering the Premises, the Tenant shall at the
election of the purchaser at such foreclosure or sale attorn to the purchaser
upon any such foreclosure or sale and recognize such purchaser as the Landlord
under this Lease in accordance with the terms of the non-disturbance Agreement.

               35.4 Landlord represents that there are no encumbrances on the
Premises, nor will there be any encumbrances on the Premises, with interests
which will be superior to Tenant's leasehold, on the date a memorandum of the
Lease is duly recorded in the Official Records of San Diego County, other than
those interests disclosed in the preliminary report described in the Project
Documents or amendments thereto delivered to Tenant prior to the execution of
this Lease. Tenant may, at Tenant's sole expense, concurrently with the
recording of the memorandum of Lease, and as a condition to the effectiveness of
the Lease, order and obtain a title insurance policy from an title insurance
company of Tenant's choice, ensuring Tenant's leasehold estate in the Premises
subject only to the exceptions set forth above and such other exceptions as
cannot ripen into a fee interest or do not materially interfere with Tenant's
quiet enjoyment of the Premises and to such deeds of trust, mortgages, ground
leases or other liens or encumbrances whose beneficiaries have executed and
delivered to Tenant recordable non-disturbance agreements.

                Notwithstanding the foregoing, Landlord shall use commercially
reasonable efforts to insure that the Premises are free of material and
mechanics' liens at 

                                     - 34 -
<PAGE>   38
Substantial Completion of the Premises, or as soon as is reasonably practical
thereafter. At the request of Tenant, Landlord shall provide such documentation
as may be reasonably requested by a title company for the purpose of allowing
the leasehold policy to be issued without listing any such liens as exceptions,
so long as Landlord incurs no expense therefor. In any event, however, Landlord
shall insure such a policy without exceptions for such liens may be issued no
later than six (6) months from Substantial Completion.

        36.    SURRENDER

               36.1 No surrender of possession of any part of the Premises shall
release Tenant from any of its obligations hereunder unless accepted by
Landlord.

               36.2 The voluntary or other surrender of this Lease by Tenant
shall not work a merger, unless Landlord consents, and shall, at the option of
Landlord, operate as an assignment to it of any or all subleases or
subtenancies.

        37.    WAIVER AND MODIFICATION

               37.1 No provision of this Lease may be modified, amended or added
to except by an agreement in writing. The waiver by Landlord of any breach of
any term, covenant or condition herein contained shall not be deemed to be a
waiver of any subsequent breach of the same or any other term, covenant or
condition herein contained.

        38.    WAIVER OF JURY TRIAL AND COUNTERCLAIMS

               38.1 The parties hereto shall and they hereby do waive trial by
jury in any action, proceeding or counterclaim brought by either of the parties
hereto against the other on any matters whatsoever arising out of or in any way
connected with this Lease, the relationship of Landlord and Tenant, Tenant's use
or occupancy of the Premises, and/or any claim of injury or damage. In the event
Landlord commences any proceedings for nonpayment of rent, or any other sums or
amounts due hereunder, Tenant will not interpose any counterclaim of whatever
nature or description in any such proceedings, except for mandatory
counterclaims; provided, however, that nothing contained herein shall be deemed
or construed as a waiver of the Tenant's right to assert such claims in any
separate action or actions brought by Tenant.

        39.    HAZARDOUS MATERIAL

               39.1 During the term, Tenant, at its sole cost, shall comply with
all federal, state and local laws, statutes, ordinances, codes, regulations and
orders relating to the receiving, handling, use, storage, accumulation,
transportation, generation, spillage, migration, discharge, release and disposal
of Hazardous Material (as hereinafter defined in Section 39.12 hereof) in or
about the Premises. Tenant shall not cause or permit any Hazardous Material to
be brought upon, kept or used in or about the Premises by Tenant, its agents,
employees, contractors, invitees or subtenants, in a manner or for a purpose
prohibited by any federal, state or local agency or authority. The accumulation
of Hazardous Material shall be in approved containers and removed from the
Premises by duly licensed carriers.

                                     - 35 -
<PAGE>   39
               39.2 Tenant shall immediately provide Landlord with telephonic
notice, which shall promptly be confirmed by written notice, of any and all
spillage, discharge, release and disposal of Hazardous Material onto or within
the Premises, including the soils and subsurface waters thereof, which by law
must be reported to any federal, state or local agency, and any injuries or
damages resulting directly or indirectly therefrom. Further, Tenant shall
deliver to Landlord each and every notice or order, when said order or notice
identifies a violation which may have the potential to adversely impact the
Premises, received from any federal, state or local agency concerning Hazardous
Material and the possession, use and/or accumulation thereof promptly upon
receipt of each such notice or order by Tenant. Landlord shall have the right,
upon reasonable notice, to inspect and copy each and every notice or order
received from any federal, state or local agency concerning Hazardous Material
and the possession, use and/or accumulation thereof.

               39.3 Tenant shall be responsible for and shall indemnify,
protect, defend and hold harmless Landlord and Landlord's Agents from any and
all liability, damages, injuries, causes of action, claims, judgments, costs,
penalties, fines, losses, and expenses which arise during or after the term of
this Lease and which result from Tenant's (or from Tenant's Agents, assignees,
subtenants, employees, agents, contractors, licensees, or invitees) receiving,
handling, use, storage, accumulation, transportation, generation, spillage,
migration, discharge, release or disposal of Hazardous Material in, upon or
about the Premises, including without limitation (i) diminution in value of the
Premises, (ii) damages for the loss or restriction on use of any portion or
amenity of the Premises, (iii) damages arising from any adverse impact on
marketing of space in the Building, (iv) damages and the costs of remedial work
to other property in the vicinity of the Premises owned by Landlord or an
affiliate of Landlord, and (v) consultant fees, expert fees, and attorneys'
fees. Landlord shall be responsible for and shall indemnify, protect, defend and
hold harmless Tenant on the same basis as above for any claims which result from
Landlord's or from Landlord's Agents receiving, handling, use, storage,
accumulation, transportation, generation, spillage, migration, discharge,
release or disposal of Hazardous Material in, upon or about the Premises.

               39.4 The indemnification of Landlord and Landlord's Agents by
Tenant pursuant to the preceding Section 39.3 includes, without limiting the
generality of Section 39.3, reasonable costs incurred in connection with any
investigation of site conditions or any cleanup, remedial, removal or
restoration work required by any federal, state or local governmental agency or
political subdivision because of Hazardous Material present in the soil,
subsoil, ground water, or elsewhere on, under or about the Premises, or on,
under or about any other property in the vicinity of the Premises owned by
Landlord or an affiliate of Landlord. Without limiting the foregoing, if the
presence of any Hazardous Material on the Premises caused or permitted by Tenant
results in any contamination of the Premises, or underlying soil or groundwater,
Tenant shall promptly take all actions at its sole expense as are necessary to
return the Premises to that condition required by applicable law, provided that
Landlord's approval of such action shall first be obtained, which approval shall
not be unreasonably withheld, except that Tenant shall not be required to obtain
Landlord's prior approval of any action of an emergency nature reasonably
required or any action mandated by a governmental authority, but Tenant shall
give Landlord prompt notice thereof.

                                     - 36 -
<PAGE>   40
               39.5 Landlord acknowledges that it is not the intent of this
Article 39 to prohibit Tenant from operating its business as described in
Article 10 or to unreasonably interfere with the operation of Tenant's business.
Tenant may operate its business according to the custom of the industry so long
as the use or presence of Hazardous Material is strictly and properly monitored
according to all applicable governmental requirements. As a material inducement
to Landlord to allow Tenant to use Hazardous Material in connection with its
business, Tenant agrees to make available to Landlord upon reasonable request a
list identifying each type of Hazardous Material to be present in or upon the
Premises and setting forth any and all governmental approvals or permits
required in connection with the presence of Hazardous Material on the Premises
("Hazardous Material Summary") and a copy of the Hazardous Material business
plan prepared pursuant to Health and Safety Code Section 25500 et seq. At
Landlord's request, and at reasonable times, Tenant shall make available to
Landlord the latest available Hazardous Materials Summary and true and correct
copies of the following documents (hereinafter referred to as the "Hazardous
Material Documents") relating to the handling, storage, disposal and emission of
Hazardous Material: permits; approvals; reports and correspondence; storage and
management plans; notice of violations of any laws; plans relating to the
installation of any storage tanks to be installed in or under the Premises
(provided said installation of tanks shall be permitted only after Landlord has
given Tenant its written consent to do so, which consent may not be unreasonably
withheld); and all closure plans or any other documents required by any and all
federal, state and local governmental agencies and authorities for any storage
tanks installed in, on or about the Premises for the closure of any such tanks.
Tenant shall not be required, however, to provide Landlord with that portion of
any document which contains information of a proprietary nature and which, in
and of itself, does not contain a reference to any Hazardous Material which are
not otherwise identified to Landlord in such documentation, unless any such
Hazardous Material Document names Landlord as an "owner" or "operator" of the
facility in which Tenant is conducting its business. It is not the intent of
this subsection to provide Landlord with information which could be detrimental
to Tenant's business should such information become possessed by Tenant's
competitors. Landlord shall treat all information furnished by Tenant to
Landlord pursuant to this Section 39.5 as confidential and shall not disclose
such information to any person or entity without Tenant's prior written consent,
which consent shall not be unreasonably withheld or delayed, except as required
by law.

               39.6 Notwithstanding other provisions of this Article 39, it
shall be a default under this Lease, and Landlord shall have the right to
terminate the Lease and/or pursue its other remedies under Article 24, in the
event that (i) Tenant's use of the Premises for the generation, storage, use,
treatment or disposal of Hazardous Material is in a manner or for a purpose
prohibited by applicable law unless Tenant is diligently pursuing compliance
with such law, (ii) Tenant has been required by any governmental authority to
take remedial action in connection with Hazardous Material contaminating the
Premises if the contamination resulted from Tenant's action or use of the
Premises, unless Tenant is diligently pursuing compliance with such requirement,
or (iii) Tenant is subject to an enforcement order issued by any governmental
authority in connection with Tenant's use, disposal or storage of a Hazardous
Material on the Premises, unless Tenant is diligently seeking compliance with
such enforcement order.

               39.7 Notwithstanding the provisions of Article 25, if (i) any
anticipated use of the Premises by a proposed assignee or subtenant involves the
generation or storage, use,


                                     - 37 -
<PAGE>   41
treatment or disposal of Hazardous Material in any manner or for a purpose
prohibited by any applicable law, (ii) the proposed assignee or sublessee has
been required by any governmental authority to take remedial action in
connection with Hazardous Material contaminating a property if the contamination
resulted from such party's action or use of the property in question and has
failed to take such action, or (iii) the proposed assignee or sublessee is
subject to a final, unappealable enforcement order issued by any governmental
authority in connection with such party's use, disposal or storage of Hazardous
Material of a type such proposed assignee or sublessee intends to use in the
Premises and shall have failed to comply with such order, it shall not be
unreasonable for Landlord to withhold its consent to an assignment or subletting
to such proposed assignee or sublessee.

               39.8 Landlord represents that, to the best of its knowledge, as
of the date of this Lease, there is no Hazardous Material on the Premises,
except as disclosed in the site assessment reports described in Section 10.2 as
items (o), (p) and (r) of the Project Documents, and except as set forth in
Section 10.3. Landlord shall provide Tenant with a further update of the Phase I
Environmental Site Assessment, and any update of the Phase II Environmental Site
Assessment recommended therein, as of the Term Commencement Date. Should an
update disclose the presence of Hazardous Material which was not disclosed in
the site assessments already received by Tenant, Landlord shall remedy the
problems to Tenant's reasonable satisfaction, and shall cause a further update
of the Phase I Environmental Site Assessment to be issued in substantial
conformity with the site assessments previously provided to Tenant. The Phase I
and Phase II Environmental Site Assessments and all updates thereto are
hereinafter referred to as the "Base Line Report," and shall be deemed
conclusive as to the condition of the Premises, unless, within ninety (90) days
of receipt, Tenant causes an inspection of its own to be conducted, which
inspection discloses the presence of Hazardous Material materially different
from that disclosed in the Base Line Report.

               39.9 At any time prior to the expiration or earlier termination
of the term of the Lease, Landlord shall have the right to enter upon the
Premises at all reasonable times and at reasonable intervals in order to conduct
appropriate tests regarding the presence, use and storage of Hazardous Material,
and to inspect Tenant's records with regard thereto. Tenant will pay the
reasonable costs of any such test which demonstrates that contamination in
excess of permissible levels has occurred and such contamination was caused by
Tenant's use of the Premises during the term of the Lease. Tenant shall correct
any deficiencies identified in any such tests in accordance with its obligations
under this Article 39 to the extent the result of Tenant's use of the Premises
during the term of this Lease.

               39.10 Tenant shall at its own expense cause an environmental site
assessment of the Premises to be conducted and a report thereof delivered to
Landlord upon the expiration or earlier termination of the Lease, such report to
be as complete and broad in scope as the Base Line Report as is necessary to
identify any impact on the Premises Tenant's operations might have had
(hereinafter referred to as the "Exit Report"). Tenant shall correct any
deficiencies identified in such report in accordance with its obligations under
this Article 39 prior to the expiration or earlier termination of this Lease.
This Article 39 is the exclusive provision in this Lease regarding clean-up,
repairs or maintenance arising from receiving, handling, use, storage,
accumulation, transportation, generation, spillage, migration, discharge,
release or disposal of 

                                     - 38 -
<PAGE>   42
Hazardous Material in, upon or about the Premises, and the provisions of
Articles 7, 10, 18, and 20 shall not apply thereto.

               39.11 Tenant's obligations under this Article 39 shall survive
the termination of the Lease.

               39.12 As used herein, the term "Hazardous Material" means any
hazardous or toxic substance, material or waste which is or becomes regulated by
any local governmental authority, the State of California or the United States
Government. The term "Hazardous Material" includes, without limitation, any
material or substance which is (i) defined as a "hazardous waste," "extremely
hazardous waste" or "restricted hazardous waste" under Sections 25515, 25117 or
25122.7, or listed pursuant to Section 25140, of the California Health and
Safety Code, Division 20, Chapter 6.5 (Hazardous Waste Control Law), (ii)
defined as a "hazardous substance" under Section 25316 of the California Health
and Safety Code, Division 2, Chapter 6.8 (Carpenter-Presly-Tanner Hazardous
Substance Account Act), (iii) defined as a "hazardous material," hazardous
substance" or "hazardous waste" under Section 25501 of the California Health and
Safety Code, Division 20, Chapter 6.95 (Hazardous Substances), (v) petroleum,
(vi) asbestos, (vii) listed under Article 9 and defined as hazardous or
extremely hazardous pursuant to Article 11 of Title 22 of the California
Administrative Code, Division 4, Chapter 20, (viii) designated as a "hazardous
substance" pursuant to Section 311 of the Federal Water Pollution Control Act
(33 U.S.C. Section 1317), (ix) defined as a "hazardous waste" pursuant to
Section 1004 of the Federal Resource Conservation and Recovery Act, 42 U.S.C.
Section 6901, et. seq. (42 U.S.C. Section 6903), or (x) defined as a "hazardous
substance" pursuant to Section 101 of the Comprehensive Environmental Response
Compensation and Liability Act, 42 U.S.C. Section 9601 et. seq. (42 U.S.C.
Section 9601).

        40.    OPTION TO EXTEND.

               40.1 Landlord grants to Tenant the right to extend the term of
this Lease for *** period under the same terms and conditions existing in the
original Lease. Tenant shall exercise such right to extend the term of this
Lease by written notice to Landlord no later than twelve (12) months prior to
the end of the original term of this Lease.

               40.2 Tenant shall not have the right to exercise the option to
extend the term, notwithstanding anything set forth above to the contrary: (a)
During the time commencing from the date Landlord gives to Tenant a written
notice that Tenant is in default under any provision of this Lease and
continuing until the default alleged in said notice is cured; (b) During the
period of time commencing on the day after a monetary obligation to Landlord is
due from Tenant and unpaid without any necessity for notice thereof to Tenant
and continuing until the obligation is paid; or (c) After the expiration or
earlier termination of this Lease. The period of time within which the option to
extend may be exercised shall not be extended or enlarged by reason of the
Tenant's inability to exercise the option because of the foregoing provisions.
At the election of Landlord, all rights of Tenant under the provisions of this
Article 40 shall terminate and be of no further force or effect even after
Tenant's due and timely exercise of an option to extend if, after such exercise,
but prior to the commencement of the extension term, (1) Tenant fails to pay to
Landlord a monetary obligation of Tenant for a period of sixty (60) days after
such obligation

* confidential treatment


                                     - 39 -

<PAGE>   43
becomes due (without necessity of Landlord to give notice to Tenant), or (2)
Tenant fails to commence to cure a non-monetary default within thirty (30) days
after the date Landlord gives notice to Tenant of such default.

     41. RIGHT OF FIRST REFUSAL TO PURCHASE PREMISES.  Tenant shall have the
right of first refusal to purchase the Premises ("Right of First Refusal") upon
the following terms and conditions:

               41.1 If at any time during the initial or any extended term of
this Lease Landlord determines to sell the Premises, Landlord shall give written
notice to Tenant ("Right of First Refusal Notice") of the economic terms and
conditions on which Landlord would be willing to sell the Premises. If Tenant,
within fifteen (15) days after receipt of Landlord's Right of First Refusal
Notice, agrees in writing to purchase the Premises on the terms and conditions
stated in the notice, Landlord shall sell and convey the Premises to Tenant on
the economic terms and conditions stated in the notice.

               41.2 If Tenant does not agree in writing to purchase the Premises
within fifteen (15) days after receipt of Landlord's Right of First Refusal
Notice, or if Landlord and Tenant have not entered into a purchase and sale
agreement within thirty (30) days thereafter, Landlord shall have the right to
sell and convey the Premises to a third party on economic terms and conditions
no more favorable than the economic terms and conditions stated in the Right of
First Refusal Notice, except that the purchase price may be two and one half
percent (2.5%) less than that stated in the Right of First Refusal Notice, and,
upon any such sale, the Right of First Refusal shall terminate. If Landlord does
not sell and convey the Premises within one hundred eighty (180) days after the
Right of First Refusal Notice, any sale transaction thereafter shall be deemed a
new determination by Landlord to sell and convey the Premises and the provisions
of this Section shall again be applicable.

               41.3 If Tenant purchases the Premises pursuant to the Right of
First Refusal, this Lease shall terminate on the date title vests in Tenant, and
Landlord shall remit to Tenant all prepaid and unearned Rent. Notwithstanding
the foregoing, if Tenant, at its option, should determine to take title to the
Premises in the name of an affiliate of Tenant, this Lease shall not terminate
on the date title vests in any such affiliate of Tenant unless Tenant and such
affiliate agree otherwise.

               41.4 The Right of First Refusal herein granted to Tenant is not
assignable separate and apart from this Lease.

               41.5 Tenant shall not have the right to exercise the Right of
First Refusal, notwithstanding anything set forth above to the contrary: (a)
During the time commencing from the date Landlord gives to Tenant a written
notice that Tenant is in default under any provision of this Lease and
continuing until the default alleged in said notice is cured; (b) During the
period of time commencing on the day after a monetary obligation to Landlord is
due from Tenant and unpaid without any necessity for notice thereof to Tenant
and continuing until the obligation is paid; or (c) After the expiration or
earlier termination of this Lease. The period of time within which the Right of
First Refusal may be exercised shall not be extended or enlarged by reason 


                                     - 40 -
<PAGE>   44
of the Tenant's inability to exercise the Right of First Refusal because of the
foregoing provisions. At the election of Landlord, all rights of Tenant under
the provisions of this Article 40 shall terminate and be of no further force or
effect even after Tenant's due and timely exercise of the Right of First
Refusal, if, after such exercise, but prior to the transfer of title, (1) Tenant
fails to pay to Landlord a monetary obligation of Tenant for a period of thirty
(30) days after such obligation becomes due (without necessity of Landlord to
give notice to Tenant), or (2) Tenant fails to commence to cure a default within
thirty (30) days after the date Landlord gives notice to Tenant of such default.

 .       42.    MISCELLANEOUS

                42.1 TERMS AND HEADINGS. Where applicable in this Lease, the
singular includes the plural and the masculine or neuter includes the masculine,
feminine and neuter. The section headings of this Lease are not a part of this
Lease and shall have no effect upon the construction or interpretation of any
part hereof.

                42.2 EXAMINATION OF LEASE. Submission of this instrument for
examination or signature by Tenant does not constitute a reservation of or
option for lease, and it is not effective as a lease or otherwise until
execution by and delivery to both Landlord and Tenant.

                42.3 TIME. Time is of the essence with respect to the
performance of every provision of this Lease in which time of performance is a
factor.

                42.4 COVENANTS AND CONDITIONS. Each provision of this Lease
performable by Tenant shall be deemed both a covenant and a condition.

                42.5 CONSENTS. Whenever consent or approval of either party is
required, that party shall not unreasonably withhold or delay such consent or
approval, except as may be expressly set forth to the contrary.

                42.6 ENTIRE AGREEMENT. The terms of this Lease are intended by
the parties as a final expression of their agreement with respect to the terms
as are included herein, and may not be contradicted by evidence of any prior or
contemporaneous agreement.

                42.7 SEVERABILITY. Any provision of this Lease which shall prove
to be invalid, void, or illegal in no way affects, impairs or invalidates any
other provision hereof, and such other provisions shall remain in full force and
effect.

                42.8 RECORDING. Within ten (10) days from the execution of this
Lease, Landlord and Tenant shall record a short form memorandum hereof, which
includes references to the right of first refusal contained herein, subject to
the requirement to execute and deliver a quitclaim deed pursuant to the
provisions of Section 34.1 hereof.

                42.9 IMPARTIAL CONSTRUCTION. The language in all parts of this
Lease shall be in all cases construed as a whole according to its fair meaning
and not strictly for or against either Landlord or Tenant.

                                     - 41 -
<PAGE>   45

                42.10 INUREMENT. Each of the covenants, conditions, and
agreements herein contained shall inure to the benefit of and shall apply to and
be binding upon the parties hereto and their respective heirs, legatees,
devisees, executors, administrators, successors, assigns, sublessees, or any
person who may come into possession of said Premises or any part thereof in any
manner whatsoever. Nothing in this Section 42.10 contained shall in any way
alter the provisions against assignment or subletting in this Lease provided.

                42.11 FORCE MAJEURE. If either party cannot perform any of its
obligations (other than Tenant's obligation to pay Rent), or is delayed in such
performance (other than Tenant's obligation to pay Rent), due to events beyond
such party's control, the time provided for performing such obligations shall be
extended by a period of time equal to the delay attributable to such events.
Events beyond a party's control include, but are not limited to, acts of God
(including earthquake), war, civil commotion, labor disputes, strikes, fire,
flood or other casualty, shortage of labor or material, government regulation or
restriction and weather conditions, but do not include financial inability to
perform.

                42.12 NOTICES. Any notice, consent, demand, bill, statement, or
other communication required or permitted to be given hereunder must be in
writing and may be given by personal delivery, by facsimile transmission, or by
mail, and if given by personal delivery or facsimile transmission shall be
deemed given on the date of delivery or transmission, and if given by mail shall
be deemed sufficiently given three (3) days after time when deposited in United
States Mail if sent by registered or certified mail, addressed to Tenant at the
Premises, or to Tenant or Landlord at the addresses shown in Section 2.1.6
hereof. Either party may, by notice to the other given pursuant to this Section,
specify additional or different addresses for notice purposes.

               42.13 AUTHORITY TO EXECUTE LEASE. Landlord and Tenant each
acknowledge that it has all necessary right, title and authority to enter into
and perform its obligations under this Lease, that this Lease is a binding
obligation of such party and has been authorized by all requisite action under
the party's governing instruments, that the individuals executing this Lease on
behalf of such party are duly authorized and designated to do so, and that no
other signatories are required to bind such party.



                                     - 42 -
<PAGE>   46
        IN WITNESS WHEREOF, the parties hereto have executed this Lease as of
the date first above written.

LANDLORD:

SCIENCE PARK CENTER LLC
A California limited liability company

By Nexus Properties, Inc.
A California corporation
Manager

By:  /s/ MICHAEL J. REIDY
     ------------------------------
        Michael J. Reidy
        Chief Executive Officer

By Neurocrine Biosciences, Inc.
A Delaware corporation
Manager

By:  /s/ PAUL W. HAWRAN
     ------------------------------
        Paul W. Hawran
        Senior Vice President


TENANT:

NEUROCRINE BIOSCIENCES, INC.
A Delaware corporation


By:  /s/ PAUL W. HAWRAN
     ------------------------------
        Paul W. Hawran
        Senior Vice President



                                     - 43 -
<PAGE>   47
                                   EXHIBIT "A"

                                   WORK LETTER


<PAGE>   48
                          ATTACHMENT A-3 TO EXHIBIT "A"

                                PROJECT PROFORMA

<PAGE>   49

                                   NEUROCRINE
                              *** SF R&D FACILITY
                           PRELIMINARY COST PRO FORMA
                                      ***

<TABLE>
<CAPTION>
<S>                                                                        <C>

***

</TABLE> 

* confidential treatment
<PAGE>   50

                                   EXHIBIT "B"

                FORM OF ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE
<PAGE>   51




                   ACKNOWLEDGEMENT OF TERM COMMENCEMENT DATE


     Pursuant to Section 4.3 of that certain Lease dated July 31, 1997, by and
between SCIENCE PARK CENTER LLC, a California limited liability company,
Landlord, and NEUROCRINE BIOSCIENCES, INC., a Delaware corporation, Tenant, for
the Premises described in the Lease located at Lot 30 of Torrey Pines Science
Center Unit No. 2, in the City of San Diego, County of San Diego, State of
California, according to Map thereof No. 12845, filed in the Office of the
County Recorder of San Diego County on July 23, 1991, we hereby acknowledge that
the Term Commencement Date of the Lease, as defined therein, is
___________________, 1998, and the Term Expiration Date of the Lease, as defined
therein, is _____________, 20____.

     IN WITNESS WHEREOF, the parties hereto have executed this Acknowledgement
of Term Commencement Date as of ______________, 1998.



LANDLORD:

SCIENCE PARK CENTER LLC
A California Limited Liability Company
By Nexus Properties, Inc.
A California Corporation
Its Manger



By:
   ----------------------------------
   Authorized Officer


TENANT:

NEUROCRINE BIOSCIENCES, INC.
A Delaware corporation


By:
  ----------------------------------
  Authorized Officer

<PAGE>   52



                                   WORK LETTER

                                TABLE OF CONTENTS
<TABLE>
<CAPTION>

                                                                                           PAGE

<S>        <C>                                                                              <C>

           ARTICLE 1 - DEFINITIONS...........................................................1
           -----------------------

1.1        Building..........................................................................1
1.2        City..............................................................................1
1.3        Construction Panel................................................................1
1.4        Cost Estimate.....................................................................1
1.5        Force-Majeure Delay...............................................................2
1.6        Improvements......................................................................3
1.7        Landlord-Caused Delay.............................................................3
1.8        Landlord's Representative.........................................................3
1.9        Project...........................................................................3
1.10       Project Architect.................................................................3
1.11       Project Contractor................................................................3
1.12       Project Package...................................................................3
1.13       Project Plans.....................................................................3
1.14       Project Schedule..................................................................3
1.15       Project Work......................................................................4
1.16       Substantially Complete............................................................4
1.17       Tenant's Construction Representatives.............................................4
1.18       Tenant's Equipment................................................................4
1.19       Tenant-Caused Delay...............................................................4

           ARTICLE 2 - GENERAL REQUIREMENTS..................................................4
           --------------------------------

2.1        Project Schedule..................................................................4
2.2        Consents and Approvals............................................................4
2.3        Approvals of Contracts............................................................5
2.4        Time of the Essence...............................................................5

           ARTICLE 3 - PROJECT PLANS.........................................................5
           -------------------------

3.1        Familiarization with Documents by Architects......................................5
3.2        Preparation and Approval of Project Plans.........................................5
3.3        Building Permit for Project Work..................................................5

           ARTICLE 4 - COST ESTIMATE FOR PROJECT WORK........................................5
           ------------------------------------------

4.1        Estimate of the Project Work Costs................................................5
4.2        Tenant Approval of Cost Estimate..................................................6
</TABLE>





                                      -i-
<PAGE>   53

<TABLE>
<S>        <C>                                                                              <C>
4.3        Tenant Approval of Payments.......................................................6
4.4        Adjustments to Cost Proforma......................................................7

           ARTICLE 5 - CONSTRUCTION..........................................................7
           ------------------------

5.1        Construction of the Project Work..................................................7
5.2        Installation of Tenant's Equipment................................................7
5.3        Tenant's Construction Representative..............................................7
5.4        Construction Period Insurance.....................................................7
5.5        Contractor and Subcontractor Insurance............................................8
5.6        As-Built Drawings.................................................................9
5.7        Reliance on Construction Warranties...............................................9

           ARTICLE 6 - COMPLETION AND RENT COMMENCEMENT......................................9
           --------------------------------------------

6.1        Completion of the Work and Commencement Date......................................9
6.2        Delivery of the Premises..........................................................9
6.3        Walk-Through.....................................................................10
6.4        Notice of Completion.............................................................10
6.5        Warranties and Guarantees........................................................10

           ARTICLE 7 - CONSTRUCTION DISPUTE RESOLUTION......................................10
           -------------------------------------------

7.1        Dispute Resolution...............................................................10
7.2        Notice...........................................................................11
7.3        Resolution by Construction Panel.................................................11
7.4        Resolution by Arbitrator.........................................................11
7.5        Interpretation and Resolution....................................................11
7.6        Continued Performance............................................................11
7.7        Binding Resolution...............................................................11
</TABLE>

ATTACHMENT A-1 TO EXHIBIT "A" - DESCRIPTION OF PROJECT PACKAGE

ATTACHMENT A-2 TO EXHIBIT "A" - PROJECT SCHEDULE




                                      -ii-
<PAGE>   54

                                   WORK LETTER

        This Work Letter ("Work Letter") dated July 31, 1997, is made by and
between SCIENCE PARK CENTER LLC, a California limited liability company
("Landlord"), and NEUROCRINE BIOSCIENCES, INC., a Delaware corporation
("Tenant"), and is attached to and made a part of the Lease of the same date by
and between such parties ("Lease").

                                    ARTICLE 1
                                   DEFINITIONS

        Capitalized terms not otherwise defined in the Lease shall have the
meaning set forth below. Except as defined in this Work Letter to the contrary,
all terms utilized in this Work Letter shall have the same meaning ascribed to
them in the Lease. When consents or approvals are to be provided by or on behalf
of either party, the term "Landlord" or "Tenant", as the case may be, shall
include Landlord's Representative and Tenant's Representative, as the case may
be. The provisions of the Lease, except where clearly inconsistent or
inapplicable to this Work Letter, are incorporated into this Work Letter.

        1.1 "BUILDING." That certain building consisting of two levels over a
subterranean area, including all core, shell and tenant improvements, as
described in the Project Plans.

        1.2 "CITY." The City of San Diego, and any other governmental agencies
and entities involved in the permit and approval process for the Project Plans.

        1.3 "CONSTRUCTION PANEL." A panel consisting of one of Landlord's
Representatives, one of Tenant's Representatives, the Project Architect, and the
Project Contractor.

        1.4 "COST ESTIMATE." An estimate of the cost of materials and
construction for completing the Project Work, including without limitation the
following (if and to the extent approved by Tenant pursuant to Section 4.2):

               (a)  "Direct Cost of Construction", which includes the costs of
labor and material provided by subcontractors to the Project Contractor,
including design-build and design-assist engineering subcontractors;

               (b)  "General Work", which includes direct costs for the
project manager, field superintendent, on-site administrative support, general
labor (including trash removal) provided by the Project Contractor,
miscellaneous materials/tools provided by the Project Contractor, on site office
supplies, blue prints, safety equipment, and security (or otherwise as required
in the Project Contractor's general conditions if approved by Tenant pursuant to
Section 4.2 hereof);



                                      -1-
<PAGE>   55

               (c)  "Permits", which includes the building permits and related
fees for the Project Work, including but not limited to plan check and building
permit fees, water, sewer and other utility connection or service fees
(including fees for excess capacity), health department fees, hazardous material
permit fees, and any other similar fees;

               (d)  "Temporary Facilities", which includes on-site trailer,
temporary electrical, water and sewer, rental furniture, telephone, trash
receptacles, toilet rental, equipment and tool rentals, and medical supplies;

               (e)  "On-Site Supervision", which includes an allocable portion
of the salary of any on-site supervisor of the Project Contractor and the cost
of any on-site construction facilities, including, but not limited to, office
supplies, postage, maintenance, telephone, and utilities, but excluding any such
items included among "General Work", "Temporary Facilities", and "Overhead";

               (f)  "Overhead", which includes general administrative overhead
of the Project Contractor associated with the Project Work, including salaries
and benefits for receptionist, secretarial, accounting, estimating, department
head supervision, licenses, legal, insurance, office supplies, postage, computer
supplies and maintenance, telephone, rent, utilities, off-site office furniture
rental, office equipment maintenance and equipment property tax, and all other
main office administrative, accounting and other overhead costs (or otherwise
described in the Project Contractor's general conditions);

               (g)  "Bonds", which includes the expense of any bond which may
be required of the Project Contractor by the City, Landlord, Tenant, or the
construction lender;

               (h)  "Insurance", which includes premiums for the insurance
described in Sections 5.4 and 5.5 hereof;

               (i)  "Contractor's  Fee", which includes a fixed amount equal 
to a percentage of the Direct Cost of Construction; and

               (j)  "Contingency", which includes an amount equal to a
percentage of the Direct Costs of Construction to be reserved for costs for
adjustments to the actual costs of subcontractor's work associated with the
scope of work as described by the Project Plans as bid and not for Changes for
revised scope of work.

        1.5 "FORCE-MAJEURE DELAY." Any delay which is attributable to any: (1)
Actual delay or failure to perform attributable to any strike, lockout or other
labor or industrial disturbance (whether or not on the part of the employees of
either party hereto or their contractors or other representatives), civil
disturbance, future order of any governmental entity claiming jurisdiction, act
of a public enemy, war, riot, sabotage, blockade, embargo, inability to secure
customary materials, supplies or labor through ordinary sources by reason of
regulation 



                                      -2-
<PAGE>   56

or order of any government or regulatory body; (2) delay attributable to the
failure to secure permits and approvals within the time periods set forth in the
Project Schedule due to action or inaction of the City; (3) delay in completing
plans and specifications because of changes in any laws (including, without
limitation, the Americans with Disabilities Act of 1990, Pub. L. 101-336 (the
"ADA")) or building requirements, or the interpretation thereof; (4) delay
attributable to lightning, earthquake, fire, rain, storm, hurricane, tornado,
flood, washout, explosion, or any other cause beyond the reasonable control of
the party from whom performance is required, or any of its contractors or other
representatives; or (5) failure of the Project Architect or the Project
Contractor, or their respective contractors, agents or employees, to act within
the time limits set forth in the Project Schedule and this Work Letter.

        1.6    "IMPROVEMENTS." Surface parking areas, landscaping, drainage,
irrigation, gutters, sidewalks, lighting, walkways, driveways and other
improvements and appurtenances relating to ingress and egress.

        1.7    "LANDLORD-CAUSED DELAY." Any delay, unless attributable to a
condition or event described as a Force-Majeure Delay, caused by the failure of
Landlord or its agents or employees to act within the time limits set forth in
the Project Schedule and this Work Letter.

        1.8    "LANDLORD'S REPRESENTATIVE."  R. Darrell Gary or 
Michael J. Reidy.

        1.9    "PROJECT."  The Land, Building and Improvements.

        1.10 "PROJECT ARCHITECT." Delawie Wilkes Rodrigues Barker & Bretton
Associates AIA, the architect selected by Tenant and retained by Landlord for
the design of the Building and Improvements, and civil engineers, structural
engineers, landscaping architects and other consultants retained by the Project
Architect.

        1.11 "PROJECT CONTRACTOR." R.G. Petty Construction, the contractor
selected by Landlord and Tenant and retained by Landlord for the construction of
the Building and Improvements.

        1.12 "PROJECT PACKAGE." Information and criteria regarding the design of
the Project, consisting of the documents described on Attachment "A-1" attached
hereto as they may be reasonably supplemented from time to time by Landlord,
Tenant or the Project Architect, so long as such supplements are approved by
Tenant.

        1.13 "PROJECT PLANS." Final calculations, designs, drawings and
specifications prepared by the Project Architect and its engineers and other
consultants for the Building and Improvements.

        1.14 "PROJECT SCHEDULE." The time and responsibility schedule for
development, design and construction of the Building and Improvements, including
time periods 




                                      -3-
<PAGE>   57

for preparation and review of construction documents, obtaining necessary
approvals, construction of the Project Work, and other performances required by
this Work Letter, whether by Landlord or by Tenant, as such schedule may be
adjusted from time to time by mutual written agreement of Landlord and Tenant or
as otherwise set forth in this Work Letter. The initial Project Schedule is
attached hereto as Attachment "A-2".

        1.15   "PROJECT WORK." The construction, purchase and/or installation of
the Building and Improvements.

        1.16   "SUBSTANTIALLY COMPLETE." "SUBSTANTIALLY COMPLETED," and
"SUBSTANTIAL COMPLETION" shall have the meaning ascribed to them in Section 4.4
of the Lease.

        1.17   "TENANT'S CONSTRUCTION  REPRESENTATIVES."  Eric Spoor (Neurocrine
Biosciences, Inc.) and J.R. (Ron) Sutliff (The Staubach Company).

        1.18   "TENANT'S EQUIPMENT." Equipment and other personal property
required by Tenant in the operation of its business, other than such personal
property installed as a part of the Project Work, including equipment and other
installations necessary for obtaining a "right to occupy" from the City.

        1.19   "TENANT-CAUSED DELAY." Any delay, unless attributable to a
condition or event described as a Force-Majeure Delay, (i) caused by the failure
of Tenant or its agents or employees to act within the time limits set forth in
the Project Schedule and this Work Letter; (ii) in receiving or installing
equipment ordered to Tenant's specifications or in receiving permits,
permissions or approvals for the storage or use of Hazardous Material which are
the responsibility of Tenant to obtain; (iii) resulting from Tenant's request
for materials, finishes or installations which are unavailable or nonstandard;
(iv) resulting from Tenant's inability or failure to procure an approved
Hazardous Material summary and business plan; (v) resulting from the untimely
delivery or installation of any of Tenant's Equipment; and (vi) caused by
physical interference with or damage to the Project Work by Tenant or its agents
or employees.

                                    ARTICLE 2
                              GENERAL REQUIREMENTS

        2.1 PROJECT SCHEDULE. Landlord and Tenant agree to develop, design and
construct the Building and Improvements in accordance with this Work Letter and
the time and responsibility criteria set forth in the Project Schedule.

        2.2 CONSENTS AND APPROVALS. Any consents or approvals required or
allowed by this Work Letter shall not be unreasonably withheld or delayed.



                                      -4-
<PAGE>   58

        2.3 APPROVALS OF CONTRACTS. Both Landlord and Tenant shall have the
right to review and approve the contracts with the Project Architect and the
Project Contractor.

        2.4 TIME OF THE ESSENCE. Landlord and Tenant agree that time and strict
punctual performance are of the essence with respect to this Work Letter and the
Project Schedule.

                                    ARTICLE 3
                                  PROJECT PLANS

        3.1 FAMILIARIZATION WITH DOCUMENTS BY ARCHITECTS. The Project Architect,
prior to preparation of the Project Plans, and each engineer, consultant and
other professional retained by the Project Architect, shall thoroughly
familiarize themselves with this Work Letter, the Project Package, all
applicable building codes, and all other applicable city, county, state and
federal ordinances, rules and regulations, including, without limitation, the
energy conservation and handicap access requirements of Title 24 of the
California Administrative Code and the Americans With Disabilities Act, and
shall prepare the Project Plans with full knowledge and compliance therewith.
The Project Architect, and each engineer retained by the Project Architect,
shall be fully qualified and licensed by the State of California to prepare the
plans they are responsible for.

        3.2 PREPARATION AND APPROVAL OF PROJECT PLANS. On or before the date
specified in the Project Schedule, the Project Architect shall prepare the
Project Plans, subject to the approval of Landlord and Tenant.

        3.3 BUILDING PERMIT FOR PROJECT WORK. On or before the date set forth in
the Project Schedule, the Project Architect shall obtain a building permit (and
any approvals and permits required from the local health department and any
other governmental agencies) required for the construction of the Project Work
from the City. If the City rejects the Project Plans and thereby prevents the
issuance of a building permit, the Project Architect shall immediately make all
necessary changes required by the City and approved by Tenant. Upon the City's
approval of the Project Plans and permit application, the building permit shall
be delivered to the Project Contractor with an approved set of Project Plans
marked "for construction". The Project Plans shall not be modified in any way
without the consent of Tenant.

                                    ARTICLE 4
                         COST ESTIMATE FOR PROJECT WORK

        4.1    ESTIMATE OF THE PROJECT WORK COSTS.

               4.1.1.    On or before the date the Project Plans are submitted
to the City for plan check, and within the period of time set forth in the
Project Schedule, Landlord and Tenant shall submit to the Project Contractor a
list of at least three acceptable subcontractors from each major trade from whom
Landlord and Tenant desire to receive bids for the Project Work; provided,


                                      -5-
<PAGE>   59

however, Landlord and Tenant may select design-build and design-assist
subcontractors on a negotiated basis.

               4.1.2.    The Project Contractor shall put Project Plans out to 
bid to the subcontractors selected by Landlord and Tenant within the time period
set forth in the Project Schedule, and shall promptly provide the bids in a form
pre-approved by Landlord and Tenant to Landlord and Tenant when received.
Landlord and Tenant shall select one subcontractor bid from each trade and
deliver a list of selected subcontractors and their respective bids to the
Project Contractor within the time period specified in the Project Schedule.

        4.2    TENANT APPROVAL OF COST ESTIMATE.

               4.2.1.    The Project Contractor shall prepare the Cost Estimate,
and shall submit to Tenant, within the time period set forth in the Project
Schedule, the Cost Estimate prepared by the Project Contractor for Tenant's
approval.

               4.2.2.    Tenant shall, within five (5) business days after 
receipt of the Cost Estimate, either approve the Cost Estimate, or disapprove
the Cost Estimate with specific instructions to the Project Architect and the
Project Contractor to reduce the scope of the Project Work.

               4.2.3.    If Tenant disapproves the Cost Estimate with 
instructions to reduce the scope of the Project Work, the Project Architect
shall revise the Project Plans accordingly, if required, and the Project
Contractor shall cause the Project Plans, as revised, to be re-bid in accordance
with Section 4.1, and shall prepare a revised Cost Estimate and deliver it to
Tenant for approval or disapproval in accordance with this Section 4.2. Any
subsequent reduction in the scope of the Project Work and re-bid shall be
subject to the same procedures as set forth in this Article 4.

               4.2.4.    Within ten (10) days after Tenant approves the original
Cost Estimate or any Revised Cost Estimate, Landlord shall enter into a
construction contract with the Project Contractor for construction of the
Project Work, and Landlord shall provide Tenant with a copy thereof. Landlord
and Tenant and their designated representatives shall have the right, at all
reasonable times, to audit the Project Contractor's financial and accounting
records in connection with the construction of the Project Work.

        4.3    TENANT APPROVAL OF PAYMENTS. Tenant shall have the right to 
approve all payments made to Landlord or any third party in connection with the
construction of the Project Work. Landlord and Tenant acknowledge that Tenant
has agreed to pay to Nexus Properties, Inc. a fee for development services
pursuant to the terms of Landlord's operating agreement. Without limiting the
generality of the first sentence of this paragraph, Tenant shall have the right
to approve all other payments to Nexus Properties, Inc. or any of its affiliates
in connection with the Project Work.



                                      -6-
<PAGE>   60

        4.4 ADJUSTMENTS TO COST PROFORMA. A preliminary cost proforma for the
construction of the Project Work is attached hereto as Attachment A-3. Upon
Tenant's approval of the Cost Estimate, Landlord and Tenant shall revise the
proforma to reflect any changes based upon the Cost Estimate. Landlord and
Tenant acknowledge that Basic Annual Rent payable under the Lease may be
adjusted pursuant to Section 6.1 of the Lease based upon the total cost for the
acquisition, development and construction of the Project Work ("Project Cost").
Landlord and Tenant agree that any such adjustment shall be based upon the final
Project Cost for the Project Work as determined by Landlord and Tenant.

                                    ARTICLE 5
                                  CONSTRUCTION

        5.1    CONSTRUCTION OF THE PROJECT WORK. As soon as practical after 
receipt of the building permit for the Project Work, the Project Contractor
shall construct the Project Work within the time period set forth in the Project
Schedule and in accordance with the Project Plans.

        5.2    INSTALLATION OF TENANT'S EQUIPMENT. Tenant agrees to install
Tenant's Equipment within the time period set forth in the Project Schedule.
Tenant's Equipment shall be installed in compliance with all governmental
ordinances, rules and regulations relating thereto and shall not be constructed
in a manner inconsistent with the approved Project Plans.

        5.3    TENANT'S CONSTRUCTION REPRESENTATIVES. At least one of Tenant's
Construction Representatives shall participate in all meetings with the Project
Contractor and subcontractors involved in the construction of the Project Work.
Any questions arising during construction shall be directed to one of Tenant's
Construction Representatives.

        5.4    CONSTRUCTION  PERIOD INSURANCE.  From the commencement until 
the completion of the Project Work, Landlord shall obtain and maintain, or shall
cause to be obtained and maintained,

               (i)  comprehensive general liability insurance, on an
occurrence basis in amounts sufficient to protect Tenant and Landlord from and
against liability for death or injury to persons and for damage to property
caused by or arising from the performance of the Project Work. All such
insurance shall name Tenant and Tenant's Representative as an additional
insureds; and

               (ii) "all risk" builder's risk insurance covering the Project
Work, including, but not limited to, coverage against loss of damage by fire,
vandalism and malicious mischief, covering improvements in place and all
material and equipment at the job site furnished under contract, in an amount
equal to one hundred percent (100%) of the full replacement value thereof.

               All of the policies of insurance referred to in this section
shall be written by companies authorized to do business in California and rated
A VII or better in Best's Insurance 



                                      -7-
<PAGE>   61

Guide. Each insurer referred to in this article shall agree, by endorsement on
the applicable policy or by independent instrument furnished to Landlord, that
it will give Landlord, and Landlord's lenders if required by such lenders, and
Tenant, at least thirty (30) days' prior written notice by registered mail
before the applicable policy shall be cancelled or altered in coverage, scope,
amount or other material term, except in the case of non-payment of premium, in
which event the policy may be cancelled on ten (10) days' prior written notice.

               Landlord's responsibility to provide insurance under this Section
5.4 shall be satisfied to the extent such insurance is provided by contractors
under the following Section 5.5 hereof.

        5.5 CONTRACTOR AND SUBCONTRACTOR INSURANCE. The Project Contractor and
all other contractors and subcontractors shall carry worker's compensation
insurance covering all of their respective employees as more particularly
specified below; and shall also carry public liability insurance, including
property damage, with limits and in the same form and with the same companies as
required to be carried by Tenant under the Lease except as stated otherwise
below; and the policies therefor shall insure Landlord and Tenant as their
interests may appear, as well as the contractor or subcontractor. Such policies
shall name Landlord, Tenant, Landlord's Representative, Tenant's Representative,
and, if requested by Landlord, Landlord's mortgagees or beneficiaries, as
additional loss payees and shall be for the mutual and joint benefit and
protection of Landlord, Tenant, and Landlord's mortgagees or beneficiaries, as
their interests may appear. The Project Contractor's and all other contractor's
and subcontractor's required minimum coverages and limits of liability are as
follows:

               (a)  Worker's compensation, including employer's liability
insurance, with limits of not less than Two Million Dollars ($2,000,000.00),
with the policy in full compliance with all current laws governing workers'
compensation insurance in California.

               (b)  Comprehensive general liability insurance (including
contractor's protective liability) in an amount not less than Two Million
Dollars ($2,000,000.00) combined single limit (CSL) bodily injury and property
damage. Such insurance shall provide for explosion, collapse, underground
hazards (X.C.U.) coverage and broad form contractual liability coverage and
shall insure the general contractor and/or subcontractors against any and all
claims for personal injury, including death resulting therefrom, and damage to
the property of others and arising from its operations under the contract and
whether such operations are performed by the general contractor, subcontractor
or any of their subcontractors, or by anyone directly or indirectly employed by
any of them. Fire liability shall be maintained in the amount of the costs of
construction or an appropriate amount deemed reasonable by the Landlord.

               (c)  Comprehensive automobile liability insurance, including
the ownership, maintenance and operation of any automotive equipment owned,
hired and non-owned in the following minimum amounts: Bodily Injury and Property
Damage, each occurrence, Combined Single Limit of One Million Dollars
($1,000,000.00).



                                      -8-
<PAGE>   62

        5.6    AS-BUILT DRAWINGS. The Project Architect and the Project 
Contractor shall maintain a set of "as-built" drawings of the Premises, which
shall be available for inspection by Landlord and Tenant at the construction
office during normal business hours. Copies of the completed set of "as-built"
drawings shall be provided to Landlord and Tenant at the completion of the
Project Work.

        5.7    RELIANCE ON CONSTRUCTION WARRANTIES. Landlord and Tenant 
acknowledge that, under Article 14 and other provisions of the Lease and this
Work Letter, each may have the non-exclusive benefit of any applicable
warranties from design professionals, contractors, materialmen, manufacturers,
or other responsible parties. Landlord and Tenant each assumes responsibility to
inquire into and be fully informed regarding provisions of any applicable
warranties, and the other party shall bear no responsibility therefor.

                                    ARTICLE 6
                        COMPLETION AND RENT COMMENCEMENT

        6.1    COMPLETION OF THE WORK AND COMMENCEMENT DATE.

               6.1.1.    Landlord shall use commercially reasonable efforts to
Substantially Complete the Project Work within the time periods indicated in the
Project Schedule and on or before the estimated Term Commencement Date set forth
in Section 2.1.4(a) of the Lease as such time is extended one day for each day
of delay resulting from a Force-Majeure Delay or Tenant-Caused Delay.

               6.1.2.    The estimated Term Commencement Date and Tenant's
obligation to pay Basic Annual Rent and Additional Rent under the Lease shall be
extended one day for each day of delay in Substantial Completion of the Project
Work which results from any cause other than a Tenant-Caused Delay.
Tenant-Caused Delays shall not extend the estimated Term Commencement Date, but
shall extend Landlord's obligation to Substantially Complete the Project Work by
the estimated Term Commencement Date.

        6.2 DELIVERY OF THE PREMISES. Landlord shall deliver the Premises to
Tenant upon Substantial Completion of the Project Work in clean and operating
condition, subject to typical punch-list items. The term "clean and operating
condition" shall include the following: (a) tile floors are wet mopped, waxed
and buffed, and carpets are vacuumed; (b) walls and partitions are cleaned and
major holes are filled and touched up; (c) glass is cleaned on both sides; (d)
trash, dirt and left-over materials are removed from the Premises and the
Building entrance area; (e) air-conditioning, heating and ventilating system is
in operating condition and approximately regulated; and (f) plumbing, electrical
and elevator systems are in operating condition. Punch-list items may include
such minor pick-up work as would not materially interfere with Tenant's
occupancy and use of the Premises for the purpose for which they are to be used;
provided, however, as to those portions of the Premises designed to be used as
scientific research laboratories, in no event shall punch-list items include
work which would unreasonably interfere



                                      -9-
<PAGE>   63

with Tenant's use of such laboratories for the purpose for which they are
intended. Any dispute between Landlord and Tenant regarding whether a punch-list
item unreasonably interferes with Tenant's use of the laboratory areas of the
Premises for the purpose for which they are intended shall be resolved in
accordance with Article 7 of this Work Letter.

        6.3    WALK-THROUGH. On or before the date Tenant occupies the Premises
for the purpose of conducting its business therein, Landlord and Tenant shall
conduct a walk-through inspection of the Premises and shall jointly prepare a
list of initial construction items that need to be corrected. Landlord shall
cause the Project Contractor to correct such items within thirty (30) days
thereafter, provided, however, if by the nature of such correction more than
thirty (30) days is required to effect such correction, Landlord shall not be in
default hereunder if such correction is commenced within such thirty (30) day
period and is diligently pursued to completion.

        6.4    NOTICE OF COMPLETION. Within five (5) days after Substantial
Completion, Landlord shall execute and file a notice of completion with respect
thereto and furnish a copy thereof to Tenant upon recordation. Tenant, at
Tenant's option, may itself execute and file the same on behalf of Landlord.

        6.5    WARRANTIES AND GUARANTEES. Each contractor and subcontractor
participating in the Project Work shall guarantee that the portion thereof for
which he is responsible shall be free from any defects in workmanship and
materials for a period of not less than one (1) year from the date of the
recording of the certificate of completion of the Premises. Every such
contractor or subcontractor shall be responsible for the replacement or repair,
without additional charge, of all work done or furnished in accordance with its
contract which shall become defective within one (1) year after the date of the
recording of the certificate of completion. The correction of such work shall
include, without additional charge, all additional expenses and damages in
connection with such removal or replacement of all or any part of the Building
and Land Improvements which may be damaged or disturbed thereby. All such
warranties or guarantees as to materials or workmanship of or with respect to
any work shall be contained in the contract or subcontract which shall be so
written that such guarantees or warranties shall inure to the benefit of both
Landlord and Tenant, as their respective interests may appear, and can be
directly enforced by either. Landlord covenants to give to Tenant any assignment
or other assurances necessary to effect such right of direct enforcement.

                                    ARTICLE 7
                         CONSTRUCTION DISPUTE RESOLUTION

        7.1    DISPUTE RESOLUTION. If any dispute arises in connection with this
Work Letter, such dispute shall be resolved in accordance with this Article. All
proceedings contemplated by this Article shall take place at the location for
all job-site meetings, unless the Construction Panel unanimously agrees to
another location, or unless any Arbitrator appointed hereunder selects another
location.



                                      -10-
<PAGE>   64

        7.2    NOTICE. All disputes to be determined in accordance with this
Article shall be raised by Landlord or Tenant by written notice to the other
party. Notice of any dispute with an issue resolved in any minutes of a periodic
on-site review meeting must be given within thirty (30) days of receipt of the
minutes, or the resolution of the issue as reflected in the minutes shall be
deemed conclusive.

        7.3    RESOLUTION BY CONSTRUCTION PANEL. The Construction Panel shall 
meet within two (2) business days of receipt of the notice and attempt in good
faith to resolve the dispute by unanimous agreement.

        7.4    RESOLUTION BY ARBITRATOR. If the Construction Panel has not 
resolved the dispute for any reason within four (4) business days of receipt of
the notice, it shall promptly select by unanimous agreement a disinterested
arbitrator ("Arbitrator") with extensive development and construction experience
to resolve the dispute. In the event a selection is not made within six (6)
business days after the written notice, the Arbitrator shall, upon the request
of Landlord or Tenant, be appointed by the American Arbitration Association.
Once an Arbitrator is appointed hereunder, such Arbitrator shall serve as
Arbitrator for all subsequent disputes arising in connection with this Work
Letter unless the Construction Panel unanimously agrees otherwise. The
Arbitrator shall resolve the dispute as soon as is reasonably practical in
accordance with the provisions of Section 1280 et seq. of the Code of Civil
Procedure. The cost for the Arbitrator's services shall be paid by the
non-prevailing party in the dispute being determined by the Arbitrator, unless
the Arbitrator determines otherwise.

        7.5    INTERPRETATION AND RESOLUTION. In determining any dispute, the
Construction Panel and the Arbitrator shall apply the pertinent provisions of
this Work Letter and the Lease. As part of resolving a dispute, the Construction
Panel or the Arbitrator, as the case may be, shall determine the days of delay,
if any, in completing the Project Work which directly result from the dispute
being considered by the Construction Panel or the Arbitrator, and from the
proceedings pursuant to this Article 7. The days of delay shall be designated as
either Force-Majeure Delays, Landlord-Caused Delays or Tenant-Caused Delays or
any combination thereof as determined by the Construction Panel or the
Arbitrator, as the case may be.

        7.6    CONTINUED PERFORMANCE. During any proceedings pursuant to this
Article, Landlord and Tenant shall, to the extent possible, continue to perform
and discharge all of their respective obligations under this Work Letter and the
Lease.

        7.7    BINDING RESOLUTION. Any and all decisions of the Construction 
Panel made by unanimous agreement as to the matter in dispute shall be binding
upon both Landlord and Tenant. In the absence of such unanimous agreement, any
and all decisions by the Arbitrator shall be binding upon both Landlord and
Tenant. The provisions of this Article 7 is an arbitration agreement enforceable
under Section 1280 et seq. of the Code of Civil Procedure.




                                      -11
<PAGE>   65

        IN WITNESS WHEREOF, the parties hereto have executed this Work Letter
to be effective on the date first above written.





LANDLORD:

SCIENCE PARK CENTER LLC
A California limited liability company

By Nexus Properties, Inc.
A California corporation
Manager

By:
   --------------------------------------
        Michael J. Reidy
        Chief Executive Officer

By Neurocrine Biosciences, Inc.
A Delaware corporation
Manager

By:
    -------------------------------------
        Paul W. Hawran
        Senior Vice President


TENANT:

NEUROCRINE BIOSCIENCES, INC.
A Delaware corporation


By:
    -------------------------------------
        Paul W. Hawran
        Senior Vice President




                                      -12
<PAGE>   66

                          ATTACHMENT A-1 TO EXHIBIT "A"

                         DESCRIPTION OF PROJECT PACKAGE


      (a) "Project Plans", as described in the Work Letter;

      (b) Hazardous Material Documents, as such are defined in Section 39.5 of
the Lease;

      (c) Declaration of Covenants, Conditions and Restrictions for Torrey Pines
Science Center (Unit 2) dated June 22, 1994, and recorded on June 27, 1994 as
File No. 1994-0405385 of the Official Records of San Diego County, California
("CC&Rs");

      (d) Articles of Incorporation and Bylaws of Torrey Pines Science Center
Association for Unit 2;

      (e) Planned Industrial Development Permit No. 86-0884 and Planning
Director Resolution No. 7658, dated September 26, 1988, as amended to
incorporate the conditions of approval of Coastal Development Permit No.
6-88-504, and including a copy of the City regulations for the SR Zone, and
amended PID 96-0738;

      (f) Coastal Development Permit No. 6-88-504, approved February 5, 1991,
and all conditions of approval thereof;

      (g) Transportation Demand Management Program for Torrey Pines Science
Center, prepared by the North City TMA Network, dated January 24, 1990;

      (h) Torrey Pines Science Center Signage Guidelines and Criteria, prepared
by Graphics Solutions, dated November 17, 1989;

      (i) Final Map No. 12845;

      (j) Provisions of the SR Zone and other applicable zoning as such may be
adopted or amended by the City of San Diego from time to time;

      (k) Preliminary title report issued by Chicago Title Company dated June 6,
1997 and identified as Order No. 007353168, as modified by that Supplemental
Report dated June 16, 1997, as further modified by that Supplemental Letter
dated June 17, 1997;

      (l) Preliminary Geotechnical Investigation prepared by Leighton Associates
dated December 19, 1989;


                                      -13-
<PAGE>   67

      (m) As-Graded Geotechnical Report prepared by Leighton Associates dated
December 12, 1991;

      (n) Grading Plans for Torrey Pines Science Center Unit 2, prepared by Rick
Engineering and approved by the City Engineer on March 13, 1991, and a
Certificate from Rick Engineering indicating that the Property has been graded
in conformance with such Grading Plans;

      (o) Phase I Environmental Site Assessment prepared by Harding Lawson
Associates dated October 19, 1988;

      (p) Phase II Environmental Site Assessment prepared by Harding Lawson
Associates dated April 17, 1989;

      (q) Updated Phase 1 Environmental Site Assessment prepared by Harding
Lawson Associates dated April 29, 1994;

      (r) Any updated Environmental Site Assessment prepared as a part of this
transaction;

      (s) Documents evidencing the release of the Property from the Licenses
described in Section 10.3 of the Lease;

      (t) Declaration of Restrictions and Maintenance Agreement executed by
Chevron Land and Development Company and recorded on February 15, 1990 as File
No. 90-086015 of the Official Records of San Diego County, California.




                                      -14-
<PAGE>   68

                          ATTACHMENT A-2 TO EXHIBIT "A"

                                PROJECT SCHEDULE


<PAGE>   1

                                                                    EXHIBIT 10.2

                                       OPTION AGREEMENT

     This Option Agreement ("Agreement") is made as of July 31, 1997, by and
between SCIENCE PARK CENTER LLC, a California limited liability company
("Optionor"), and NEUROCRINE BIOSCIENCES, INC., a Delaware corporation
("Optionee"), sometimes collectively referred to herein as the "parties."

                                           RECITALS

        A.     Optionor will concurrently herewith purchase form Optionee that 
certain real property legally described as Lot 30 of Torrey Pines Science Center
Unit No. 2, in the City of San Diego, County of San Diego, according to Map
thereof No. 12845, filed in the Officer of the County Recorder of San Diego
County on July 23, 1991 (the "Land") for a purchase price of $3,472,000. The
entirety of the purchase price was financed by a loan from Optionee to Optionor.
Optionor intends to develop and construct (i) an *** square foot building on
the Land to consist of two levels over a subterranean area (the "Building"), and
(ii) landscaping, drainage, irrigation, lighting, parking facilities, walkways,
driveways and other improvements and appurtenances related thereto (the
"Improvements). The Land, Building and Improvements are sometimes collectively
referred to herein as the "Premises".

        B.     Optionor will construct the Building and Improvements with a
construction loan (the "Tokai Construction Loan") from Tokai Bank of California
("Tokai Bank") in the approximate amount of *** a construction loan from
Optionee in the approximate amount of $368,000, and a cash contribution from
Nexus Properties, Inc. ("Nexus"), a member of Optionor, in the amount of ***.
The Tokai Construction Loan in the amount of *** will be secured by a first deed
of trust on the Premises, and the construction loan from Optionee and the loan
to finance the purchase price of the Land in the aggregate amount of $3,840,000
(the "Neurocrine Loan"), will be secured by a second deed of trust on the
Premises. Following completion of construction, Optionor contemplates obtaining
a permanent loan (the "Permanent Loan") to replace the Tokai Construction Loan.

        C.     Concurrently herewith Optionor has leased the Premises to 
Optionee to be used by Optionee for scientific research and development
laboratories and related office and ancillary uses pursuant to that certain
lease ("Lease") of even date executed by Optionor as landlord ("Landlord") and
Optionee as tenant ("Tenant").

        D.     Optionee is a member of Optionor pursuant to the Operating 
Agreement of Optionor (the "Operating Agreement") executed by Optionee and Nexus
concurrently herewith.

        E.     Optionor desires to grant Optionee an option to purchase the 
Premises and Optionee desires to acquire an option to purchase the Premises upon
the terms and conditions set forth herein.

* Certain confidential portions of this Exhibit were omitted by means of
  blackout of the text (the "Mark"). This Exhibit has been filed separately with
  the Secretary of the Commission without the Mark pursuant to the Company's
  Application Requesting Confidential Treatment under Rule 24b-2 under the
  Securities Exchange Act.


                                      -1-

<PAGE>   2

        NOW, THEREFORE, in consideration for the execution of the Lease, the
premises set forth above, the mutual covenants and conditions set forth herein,
and for other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, Optionor and Optionee hereby agree as follows:

        1.     GRANT OF OPTION.  Optionor hereby grants to Optionee an option 
to purchase the Premises from Optionor upon the terms and conditions set forth
in this Agreement (the "Option"). ---------------

        2. TERM OF OPTION. The term of the Option shall commence ***, and shall
terminate upon ***. In the event the Lease is terminated prior to the expiration
of the term by a bankruptcy of the landlord thereunder, the term of the Option
shall be automatically extended for so long as the tenant is entitled to remain,
and does remain, in possession of the Premises. In the event the Lease is
terminated prior to the expiration of the term for any other reason other than a
default of the tenant thereunder, the term of the Option shall be automatically
extended for a period of thirty (30) days following the date of termination.

        3.     EXERCISE OF OPTION.  The Option may be exercised by Optionee at 
any time during the term (and any extensions thereof) of the Option by delivery
to Optionor of a written notice setting forth Optionee's intention to purchase
the Premises pursuant to this Agreement. 

        4.     CONDITIONS ON EXERCISE OF OPTION.  Optionee shall not have the 
right to exercise the Option (i) during the period of time commencing on the day
after a monetary obligation to Landlord is due under the Lease from Tenant and
unpaid without any necessity for notice thereof to Tenant and continuing until
the obligation is paid, or (ii) except as otherwise provided in paragraph 2
hereof to the contrary, after the expiration or earlier termination of the term
of the Lease.
     

        5.     PURCHASE PRICE. The purchase price ("Purchase Price") for the
Premises shall be an amount ***. At the election of Optionee, and with the
consent of the obligee, Optionee may assume any loan or other monetary
encumbrance secured by the Premises and credit the amount of the assumption
against the Purchase Price, so long as Optionee obtains the release of Nexus as
set forth in Section 8 below. Additionally, at the election of Optionee, and
with the consent of the obligee, Optionee may assume any contingent or long-term
contractual obligation of Optionor (e.g., the 

* confidential treatment




                                      -2-
<PAGE>   3

Lease or a property management agreement) in lieu of making a cash payment in
satisfaction thereof. A pro forma illustrating the Purchase Price is attached
hereto as an exhibit and incorporated herein by this reference.

        6.     PAYMENT OF CLOSING EXPENSES.  Optionee shall pay any and all 
costs and expenses of appraisers, surveyors, attorneys, title companies,
lenders, escrow companies, and other consultants, and any and all other costs
and expenses related to the purchase of the Premises pursuant to this Agreement,
so that the payment of the Purchase Price shall be absolutely net to Optionor,
and Optionor shall be put to no expense or liability whatsoever with regard to
the exercise of the Option or the purchase of the Premises pursuant to the
Option.

        7.     OPENING OF ESCROW.  The parties shall open an escrow for 
Optionee's purchase of the Premises within fifteen (15) days after Optionee's
exercise of the Option by depositing one fully executed original of a purchase
and sale agreement and escrow instructions in a form consistent with this
Agreement and satisfactory to the parties with an escrow holder selected by the
parties. 

        8.     CONDITIONS TO CLOSE OF ESCROW. As a condition to the close of 
escrow for the purchase of the Premises pursuant to this Agreement, Optionee
shall (i) obtain the release of Nexus and its officers, directors, shareholders,
employees, attorneys, agents and affiliates from any and all liability for loans
secured by the Premises and any and all other debts and liabilities of Optionor
(to the extent such persons are personally liable for such loans, debts and
liabilities), and (ii) agree to indemnify, defend and hold harmless Nexus and
its officers, directors, shareholders, employees, attorneys, agents and
affiliates from and against any claims and liability therefore, except for any
such liability incurred through the gross negligence or willful misconduct of
Nexus.

        9.     "AS IS" PURCHASE.  Optionee will acquire the Premises in an "AS 
IS" condition, and expressly waives and negates the right to any express or
implied warranties from Optionor, including, but not limited to, all implied
warranties of merchantability, condition, suitability or fitness for any
particular purpose, and all warranties with respect to quality, capacity,
workmanship and latent defects. Optionee assumes the risk of adverse physical
conditions or the applicability and effect of governmental laws, ordinances,
rules, regulations and requirements, and Optionor shall have no obligation to
correct any condition or alleged defects in the Premises.

        10.    EXCHANGE RIGHTS.  Optionor agrees that Optionee may acquire the 
Premises through a third party as part of a like kind exchange pursuant to
Section 1031 of the Internal Revenue Code. Optionor shall cooperate with
Optionee in effecting such an exchange and shall execute such documents as may
be reasonably required to consummate the exchange, provided the closing shall
not be unduly delayed as a result of such exchange and Optionor shall not incur
any additional costs or assume any additional liabilities as a result of such 
exchange.

        11.    REAL ESTATE BROKERS.  Optionee and Optionor represent and warrant
to each other that no real estate broker or finder has been or will be employed
by either party with respect to 




                                      -3-
<PAGE>   4

this Agreement or the negotiation or consummation of the Option. Optionor and
Optionee shall indemnify and hold each other harmless from any and all cost,
expense or liability (including reasonable attorney's fees) for claims by real
estate brokers or finders for compensation of commissions as a result of the act
of the indemnifying party.

        12.    ASSIGNMENT.  Optionee may assign the Option herein granted 
without the consent of Optionor, on the conditions that no such assignment shall
release Optionee from its obligations hereunder, and the assignee shall assume
the obligations of Optionee under this Agreement and be bound by all of the
terms and conditions of this Agreement to the same extent as Optionee.
           

        13.    SUBORDINATION.  This Agreement shall be subject and subordinate 
to the lien of any mortgage or deed of trust which may now or hereafter encumber
the Premises. 

        14.    MISCELLANEOUS.

               14.1      TERMS AND HEADINGS.  Where applicable in this 
Agreement, the singular includes the plural and the masculine or neuter includes
the masculine, feminine and neuter. The section headings of this Agreement are
not a part of this Agreement and shall have no effect upon the construction or
interpretation of any part hereof. 

               14.2      TIME.  Time is of the essence with respect to the 
performance of every provision of this Agreement in which time of performance is
a factor. 

               14.3      COVENANTS AND CONDITIONS.  Each provision of this 
Agreement performable by Optionee shall be deemed both a covenant and a
condition. 

               14.4      CONSENTS.  Whenever consent or approval of either 
party is required, that party shall not unreasonably withhold or delay such
consent or approval, except as may be expressly set forth to the contrary.
            

               14.5      ENTIRE AGREEMENT.  The terms of this Agreement are 
intended by the parties as a final expression of their agreement with respect to
the terms as are included herein, and may not be contradicted by evidence of any
prior or contemporaneous agreement. 

               14.6      SEVERABILITY.  Any provision of this Agreement which 
shall prove to be invalid, void, or illegal in no way affects, impairs or
invalidates any other provision hereof, and such other provisions shall remain
in full force and effect. 

               14.7      RECORDING.  Optionor or Optionee shall record a short 
form memorandum of this Agreement with the County Recorder of San Diego County.


               14.8      IMPARTIAL CONSTRUCTION.  The language in all parts of 
this Agreement shall be in all cases construed as a whole according to its fair
meaning and not strictly for or against either Landlord or Tenant.



                                      -4-
<PAGE>   5

               14.9      INUREMENT.  Each of the covenants, conditions, and 
agreements herein contained shall inure to the benefit of and shall apply to and
be binding upon the parties hereto and their respective heirs, legatees,
devisees, executors, administrators, successors, assigns, sublessees, or any
person who may come into possession of the Premises or any part thereof in any
manner whatsoever.


               14.10 NOTICES. Any notice, consent, demand, bill, statement, or
other communication required or permitted to be given hereunder must be in
writing and may be given by personal delivery, by facsimile transmission, or by
mail, and if given by personal delivery or facsimile transmission shall be
deemed given on the date of delivery or transmission, and if given by mail shall
be deemed sufficiently given three (3) days after time when deposited in United
States Mail if sent by registered or certified mail, addressed to Tenant at the
Demised Premises, or to Tenant or Landlord at the addresses shown below. Either
party may, by notice to the other given pursuant to this Section, specify
additional or different addresses for notice purposes.

               Optionor:     Science Park Center LLC
                             4350 La Jolla Village Drive, Suite 930
                             San Diego, California 92122

               Optionee:     Neurocrine Biosciences, Inc.
                             10555 Science Center Drive
                             San Diego, California 92121








                                      -5-
<PAGE>   6


        IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the date first above written.

Optionor:

SCIENCE PARK CENTER LLC
A California limited liability company

By Nexus Properties, Inc.
A California corporation
Manager

By: /s/ MICHAEL J. REIDY
    -------------------------------------
        Michael J. Reidy
        Chief Executive Officer

By Neurocrine Biosciences, Inc.
A Delaware corporation
Manager

By: /s/ PAUL W. HAWRAN
    -------------------------------------
        Paul W. Hawran
        Senior Vice President


Optionee:

NEUROCRINE BIOSCIENCES, INC.
A Delaware corporation


By: /s/ PAUL W. HAWRAN
    -------------------------------------
        Paul W. Hawran
        Senior Vice President


                                      -6-





<PAGE>   1
                                                                    EXHIBIT 10.3



                           CONSTRUCTION LOAN AGREEMENT


        THIS CONSTRUCTION LOAN AGREEMENT ("Agreement") is made as of July 31,
1997, between NEUROCRINE BIOSCIENCES, INC., a Delaware corporation ("Lender")
and SCIENCE PARK CENTER LLC, a California limited liability company
("Borrower"), with reference to the Recitals set forth below.



                                    RECITALS

        A. Lender and Borrower entered into that certain Purchase and Sale
Agreement and Escrow Instructions, dated July 31, 1997, (the "Purchase
Agreement") whereunder Lender agreed to sell to Borrower and Borrower agreed to
purchase from Seller certain unimproved real property located in the City of San
Diego, County of San Diego, State of California, including, among other real
property, the parcel of land described in Exhibit "A" attached
hereto (the "Property").

        B. Borrower intends to construct on the Property a two-story laboratory
and office building containing approximately *** square feet of building area
over a *** square foot subterranean area (the "Building") in addition to other
related improvements (collectively, the "Project"). Further, Borrower intends to
lease to Lender, and Lender intends to lease from Borrower, the Property, the
Building and certain related improvements to be constructed on the Property
pursuant to a Lease between Borrower, as landlord, and Lender, as tenant, of
even date herewith (the "Lease"). In connection therewith, Borrower intends to
grant Lender an option to purchase the Property from Borrower pursuant to an
Option Agreement between Borrower and Lender of even date herewith (the "Option
Agreement").

        C. The total cost of the Project is estimated to be ***. To finance the
Project, Borrower intends to obtain a construction loan from Tokai Bank of
California, a California banking corporation ("Tokai"), in the principal amount
of *** (the "Tokai Loan") to be evidenced by a promissory note (the "Tokai
Note") and secured by a first priority Deed of Trust, Assignment of Rents and
Leases, Security Agreement and Fixture Filing against the Property (the "Tokai
Deed of Trust"), an Absolute Assignment of Leases, Rents and Lease Guaranties
(the "Tokai Assignment of Leases"), an Assignment of Construction Contract (the
"Tokai Assignment of Construction Contract") and an Assignment of Architect's
Contract and Plans and Specifications (the "Tokai Assignment of Architect's
Contract"). The Tokai Loan will be replaced by a permanent loan from Tokai in
the same principal amount with interest at a fixed rate of interest in
accordance with the terms of a separate term loan commitment (the "Permanent
Loan").

        D. Borrower has applied to Lender for a loan (the "Loan") in the
principal amount of $3,840,000.00 to be evidenced by a promissory note (the
"Note") secured by a Deed of Trust, Assignment of Rents and Leases, Security
Agreement and Fixture Filing against the Property (the "Lender Deed of Trust")
and an Assignment of Contracts, Licenses, Permits, Agreements, Warranties, Plans
and Specifications (the "Lender Assignment of Contracts") in addition to any


* Certain confidential portions of this Exhibit were omitted by means of
  blackout of the text (the "Mark"). This Exhibit has been filed separately with
  the Secretary of the Commission without the Mark pursuant to the Company's
  Application Requesting Confidential Treatment under Rule 24b-2 under the
  Securities Exchange Act.

                                      -1-
<PAGE>   2

other security interests and assignments which may be required by Lender in
connection with the Loan. The Loan, if funded, will be used for purposes of (i)
Borrower's acquisition of the Property pursuant to the Purchase Agreement, (ii)
the payment of certain expenses and costs incurred by or for Borrower in
connection with the Project prior to the closing of the Loan (the "Closing"), if
funded, and (iii) payment of portions of the Project Costs (as defined below).

        E. Lender has agreed to make the Loan to Borrower on the terms and
subject to the conditions set forth in this Agreement.

        NOW, THEREFORE, in consideration of the Loan, the mutual covenants and
agreements set forth below, and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, Lender and Borrower
agree as set forth below.

        1. THE LOAN. Lender agrees to make the Loan to Borrower on the terms and
subject to the conditions provided herein. Borrower acknowledges that it has no
right to the proceeds of the Loan other than to have the same disbursed in
accordance with the terms and conditions of this Agreement. Upon the
satisfaction of such terms and conditions, the proceeds of the Loan shall be
disbursed as set forth below. Upon the occurrence of an Event of Default (as
defined below), all obligations of Lender to make further disbursements of the
Loan shall cease.

               1.1 PROJECT BUDGET AND APPLICATION OF LOAN PROCEEDS. The purpose
of the Loan is to (i) finance Borrower's acquisition of the Property, (ii) pay
certain costs and expenses incurred by or for Borrower in connection with the
Project prior to the Closing and (iii) deposit the balance in an account with
Tokai to partially fund the construction costs of the Project (collectively, the
"Project Costs") as set forth in the budget for the Project attached hereto as
Exhibit "B" (the "Project Budget"). As used herein, the term "Project Budget"
shall mean the budget for the Project in effect from time to time, including all
subsequent amendments thereto. Any amendments to the Project Budget shall be
subject to the approval of Lender, which approved may be given or withheld in
Lender's sole and absolute discretion. Lender shall disburse the Loan proceeds
only for the purposes set forth above and in the Project Budget, as further
provided in Section 3 below.

               1.2 CONSTRUCTION OF PROJECT IN ACCORDANCE WITH PROJECT BUDGET.
Borrower shall construct the Project in accordance with the Project Budget.
Borrower has prepared the Project Budget using its good faith best efforts and
with all due diligence ordinarily associated with a sophisticated developer and
builder of projects similar to the Project. Borrower represents to Lender that
amounts reflected in the Project Budget for work performed by entities
affiliated with Borrower do not exceed amounts that would be paid in the normal,
customary marketplace in San Diego, California, and that to the extent Borrower


                                      -2-
<PAGE>   3

intends to or does engage entities affiliated with Borrower to work on the
Project, that the Project Budget is not increase above the normal, customary
marketplace as a result thereof. As used in this Agreement, "affiliate" shall
mean any person or entity, directly or indirectly, controlling, controlled by,
or under common control with the person or entity in question.

               1.3 VARIATIONS IN PROJECT BUDGET. The Project Budget has been
received and approved by Lender as an itemized line item construction budget and
cost estimate for all work necessary to complete the Project. In the event that
Borrower becomes aware of any material variation in the actual costs incurred or
which will be incurred in the future to construct the Project or any portion
thereof from those shown in the Project Budget, Borrower shall promptly notify
Lender in writing. For purposes of this Section 1.3 only, material variation
shall mean the first variation for the Project in the aggregate in excess of
$40,000.00 calculated on a net basis, and subsequent variations in the aggregate
in excess of $10,000.00 each. Changes to the Project Budget shall require the
prior written approval of Lender, which approval may be given or withheld in
Lender's reasonable discretion.

               1.4 COST OVERRUNS. Borrower shall use its good faith efforts to
prevent cost overruns in connection with the Project. Lender agrees to advance
additional principal amounts equal to, and for payment of, cost overruns that
Borrower is required to pay (and which cannot be funded from Tokai Loan proceeds
or the then existing Loan proceeds) pursuant to the terms of the Tokai Loan
Documents, unless such cost overruns result from the negligence or willful
misconduct of Borrower or its employees, contractors, subcontractors, agents or
representatives. Lender may also advance additional principal amounts for cost
overruns which are not required pursuant to the Tokai Loan Documents, but Lender
elects to pay in its discretion. In no event, however, shall Lender be required
to fund any shortfall under the Tokai Loan in the event Tokai Bank does not
disburse the entirety of the Tokai Loan because of a default by any party other
than Lender. For purposes of this Agreement, "cost overruns" shall mean actual
costs of the Project allocated to any line item in the Project Budget to the
extent they exceed such line item amount in the Project Budget. All additional
principal so advanced shall constitute additional principal under the Note,
shall bear interest as provided under the Note and shall be repaid pursuant to
the terms of the Note. The repayment of such additional principal and interest
thereon shall be secured by the Lender Deed of Trust, the Lender Assignment of
Contracts and such other security interest as Lender may obtain pursuant to the
terms of this Agreement. Borrower agrees to execute such further documents and
instruments and take such further actions as Lender may reasonably request to
amend, supplement, restate or modify the Loan Documents and any title policies
in order to evidence such additional indebtedness and to obtain, perfect and
assure proper priority of Lender's security interests with respect to Borrower's
obligation to repay such additional indebtedness.

        2. CONDITIONS TO CLOSING. Prior to and as a condition to the Closing and
Lender's obligation to fund the Loan, each condition to the funding of the Loan
set forth in this Agreement, including, without limitation, the following
conditions, must be satisfied or 




                                      -3-
<PAGE>   4

waived by Lender in Lender's sole and absolute discretion. All documents and
instruments required hereunder must be in form and content acceptable to Lender
and its counsel and all other conditions must be performed to the satisfaction
of Lender. To the extent possible, Lender shall review and consider information
provided to Tokai in order to satisfy the following conditions.

               2.1 ACQUISITION OF THE PROPERTY. Borrower shall have purchased
the Property from Lender as evidenced by a grant deed from Lender to Borrower
granting good and marketable title to the Property, in fee simple, to Borrower.

               2.2 LOAN DOCUMENTS. This Agreement and the other documents and
instruments listed or described in Exhibit "C" attached hereto (collectively
with this Agreement, the "Loan Documents") shall have been executed by the
appropriate person(s), acknowledged where appropriate, and delivered to Lender.

               2.3 TOKAI LOAN DOCUMENTS. The Tokai Note, the Tokai Deed of
Trust, the Tokai Assignment of Leases, the Tokai Assignment of Construction
Contract, the Tokai Assignment of Architect's Contract and all other documents
and instruments required to be signed and delivered by Borrower as a condition
to the Tokai Loan (collectively, the "Tokai Loan Documents") shall have been
executed by the appropriate person(s), acknowledged where appropriate, and
delivered to Tokai.

               2.4 TITLE INSURANCE. Lender shall have received an ALTA lender's
title insurance policy (Form 1970) dated as of the recordation of the Lender
Deed of Trust with extended coverage in the amount of the Loan (the "Title
Policy"). Lender may, at its election, require an LP-10 title policy package.
The Title Policy shall insure Lender as the holder of the Lender Deed of Trust
with the priority junior only to the Tokai Deed of Trust (and other encumbrances
of title perfecting security interests of Tokai in connection with the Tokai
Loan), insuring that the Lender Deed of Trust encumbers Borrower's title to the
Property. The Title Policy shall be issued by a title company acceptable to
Lender, and shall contain such endorsements as Lender may require. The Title
Policy shall insure that the Property is (i) subject only to the exceptions
listed on Exhibit "D" attached hereto and incorporated herein ("Permitted
Exceptions"), (ii) free of the possibility of any prior mechanics' or
materialmen's liens, and (iii) that all taxes and assessments affecting the
Property or any part thereof, due and payable on the date of the Closing shall
have been paid. At Borrower's expense, the Title Policy shall be updated at the
time of each Advance hereunder if requested by Lender and shall reflect that the
Lender Deed of Trust encumbers all of the Property owned by Borrower on the date
of each such Advance subject only to the items listed in (i), (ii) and (iii)
above. In addition to the Title Policy, Lender shall also receive, at Borrower's
expense, such other and further title insurance policies and subsequent rewrites
and updates from such title companies, with such coverage and with such
endorsements as Lender may elect insuring Lender's leasehold estate in the
Property pursuant to the Lease and Lender's rights as the optionee under Option
Agreement.





                                      -4-
<PAGE>   5

               2.5 TOKAI LOAN. Borrower shall have secured the Tokai Loan for
the Project. Borrower shall use its good faith best efforts to secure the Tokai
Loan with the most favorable loan-to-value ratio available in the marketplace.
The Tokai Loan and the Tokai Loan Documents executed by Borrower must contain
the provisions and/or satisfy the requirements set forth in Subsections 2.5.1
through 2.5.3, below. Concurrently with the delivery of any documents to or
requests for any advances of proceeds from Tokai, Borrower shall deliver copies
of all such documents and requests for advances to Lender.

                      2.5.1  TOKAI LOAN AMOUNT.  The Tokai Loan shall be in an 
amount not less than $14,760,000.00 and otherwise in the amounts set forth in
the Project Budget, and shall provide financing for all of the items set forth
in the Project Budget.

                      2.5.2  TOKAI LOAN DOCUMENTS.  The Tokai Loan Documents 
shall provide that the proceeds thereof shall be available in not less than
regular monthly draws to finance the construction of the Project.

                      2.5.3  OTHER TERMS AND CONDITIONS.  All other terms and 
conditions of the Tokai Loan Documents shall be subject to the reasonable
approval of Lender herein, which approval will not be unreasonably withheld and
will be given if such terms and conditions are consistent with those typical for
similar construction loans made by institutional lenders in the locale of the
Project.

               2.6 FEES AND EXPENSES. Borrower shall have paid to Lender all
attorneys' fees and out-of-pocket costs and expenses incurred by Lender in
connection with the negotiation, preparation, execution and delivery of this
Agreement and the other Loan Documents and any matters related thereto,
including, but not limited to, all costs, fees, premiums and expenses of the
Title Policy, any additional title insurance and endorsements as may be required
by Lender from time to time pursuant to this Agreement and all escrow costs in
connection with the escrow for the Closing.

        All of the above items must be satisfied by October 1, 1997, and if they
have not been satisfied by that date, then Lender shall have no obligation to
fund the Loan or any portion thereof and Lender shall have no further
obligations or liabilities of any kind under or in connection with this
Agreement.

        3.     ADVANCES.

               3.1 ADVANCES. Provided all of the conditions precedent to
Lender's obligation to fund the Loan are satisfied, the Loan shall be funded in
advances ("Advance(s)"), as set forth below.

                      3.1.1  FIRST ADVANCE.  The first Advance of Loan proceeds
(the "First Advance") shall be disbursed at Closing to fund Borrower's
acquisition of the Property and 




                                      -5-
<PAGE>   6

Borrower's reasonable Closing costs, including, without limitation, reasonable
title insurance costs, recording fees, loan fees, lender expenses and escrow
fees.

                      3.1.2  SECOND ADVANCE.  The second Advance of Loan 
proceeds (the "Second Advance") shall be disbursed at Closing to Borrower and/or
directly to creditors of Borrower, as Lender may elect, to reimburse or pay for
those costs and expenses incurred by or for Borrower prior to the Closing in
connection with the Project. Borrower shall provide to Lender legible copies of
all invoices and other written evidence of such costs and expenses as Lender may
require.

                      3.1.3  THIRD ADVANCE.  The third Advance of Loan proceeds
(the "Third Advance") shall equal the balance of the total principal of the
Loan, if any, after disbursement of the First and Second Advances. The Third
Advance shall be delivered at the Closing to a deposit account administered by
Tokai. The Third Advance shall be used by Tokai for the first disbursement(s) of
funds to or on behalf of Borrower pursuant to the initial requests for advances
by Borrower for Project Costs in accordance with the Tokai Loan Agreement.

               3.2 USE OF LOAN PROCEEDS. All sums disbursed by Tokai and Lender
may be used only in the Project and only in accordance with Tokai's requirements
and the requirements hereunder. No monies may be disbursed to Borrower for any
other purpose.

        4. SUBORDINATION OF DEED OF TRUST. Lender will subordinate the priority
the Lender Deed of Trust and Lender's UCC-1 Financing Statement filed in
connection therewith to the Tokai Deed of Trust and the UCC-1 Financing
Statement filed in connection therewith, provided that the Tokai Deed of Trust
and UCC-1 Financing Statement are in form and content acceptable to Lender and
its counsel.

        5. CONSTRUCTION OF THE PROJECT.

               5.1 CONSTRUCTION. Borrower covenants to complete construction of
improvements on the Property in accordance with this Agreement, the Plans and
Specifications, the Project Budget and as required under the Tokai Loan
Documents. No changes in such Plans and Specifications shall be made without
Lender's prior written consent, which consent shall not be unreasonably
withheld. By way of example, and not limitation, Lender will approve proposed
changes to the extent they are (a) in conformance with all requirements of the
Tokai Loan Documents, and (b) do not materially and adversely affect the timing,
scope or design of the Project.

               5.2 COMPLETION. Construction of the Project shall be performed
expeditiously to substantial completion by Borrower on or before the date
therefor provided in Borrower's Construction Contract with R.G. Petty
Construction, which shall in no event be later than the date required for
substantial completion in the Tokai Loan Agreement.



                                      -6-
<PAGE>   7

                      5.2.1  WARRANTY OF COMPLETION AND WARRANTY OF 
CONSTRUCTION. Borrower hereby represents and warrants that (i) the Project will
be completed in accordance with the Plans and Specifications, free and clear of
all liens and encumbrances and within the time set forth herein, (ii) the
Project and its construction shall comply with all applicable laws, ordinances,
rules and regulations, including without limitation, building and zoning laws,
codes, ordinances, rules and regulations, (iii) that, on completion of
construction, the Building shall be of a quality which is equal to or of higher
quality as first class buildings of similar uses in San Diego, California, and
(iv) that all utility services necessary for the operation of the Project shall
have been provided to the Project and shall be adequate for their intended use.

                      5.2.2  INSURANCE.  Upon completion of construction of the
Project, original, paid-up, fire and extended coverage insurance policies of
companies and in form and amount acceptable to Lender, in Lender's favor, shall
be delivered to Lender with respect to the Building and the other improvements
of the Project. Said insurance shall contain an agreed value endorsement in an
amount not less than one hundred percent (100%) of the full replacement cost of
the Building and all other improvements of the Project. Borrower agrees to
update the agreed value in this endorsement yearly. The policies shall contain a
replacement cost endorsement without deduction for depreciation and loss of
rents and/or business interruption insurance coverage and inflation coverage
commonly referred to as a "fluctuating value endorsement." Borrower will also
maintain liability and other insurance with respect to the Property, the
Building and other improvements of the Project as Lender may request from time
to time in amounts and with companies as Lender requests.

                      5.2.3  CERTIFICATE OF COMPLETION.  Upon completion of the
Project, a final Certificate of Completion by the persons making the inspections
on Borrower's behalf shall be delivered to Lender, certifying that the Building
and all other improvements of the Project have been completed in accordance with
the Plans and Specifications and in accordance with applicable laws.

                      5.2.4  CERTIFICATE OF OCCUPANCY.  Upon the completion of 
the Project, a final certificate of occupancy and/or other evidence acceptable
to Lender shall be furnished to Lender certifying that the Building and all
other improvements of the Project and their use comply fully with all applicable
zoning, building, and other governmental laws and requirements.

               5.3 NO LIENS. No materials, fixtures, or any other part of the
improvements to be used in the Project shall be purchased or installed under
conditional sales agreements or other arrangements wherein the right is reserved
or may accrue to anyone to remove or repossess any such items. Borrower will
keep the Project free from liens and claims of all kinds, whether or not
superior to Lender Deed of Trust.



                                      -7-
<PAGE>   8

               5.4 RELEASE OF LIENS. If any claim of lien is filed against the
Project, or if notice of intent to file such a lien is received by Lender or any
construction lender, or if a judgment or other encumbrance is placed against the
Project, such shall constitute an Event of Default unless Borrower obtains a
release and satisfaction of such lien, claim of lien, judgment or encumbrance,
or provides Lender with a bond acceptable to Lender in the amount of one hundred
fifty percent (150%) of the lien, claim of lien, judgment or encumbrance within
twenty (20) days of written notice by Lender to Borrower of the existence of
such claim of lien or encumbrance. Prior to such becoming an Event of Default,
Lender may, at its option, restrict disbursements of Loan funds such that there
would be sufficient sums to pay one hundred fifty percent (150%) of the lien,
claim of lien, judgment and other encumbrance against the Property. If Borrower
does not post the bond or other security satisfactory to Lender within said
twenty (20) days, Lender may, at its option, advance sums to pay such lien,
claim of lien, judgment and other encumbrance against the Property. Lender's
rights under this Section shall not be affected by any claim of Borrower that
the lien, judgment or encumbrance is invalid, it being understood that the
decision of the Lender to pay or withhold is to be made by Lender in its sole
exercise of discretion, subject only to Borrower's right to provide a bond or
other security satisfactory to Lender as provided above.

        6. REPAYMENT OF LOAN; TERM OF LOAN. Outstanding principal balances under
the Loan shall bear interest at the rate set forth in the Note. The principal
and interest of the Loan shall be repaid by Borrower in accordance with the
terms of the Note. All payments hereunder or under the Note shall be made by
Borrower without offset or deduction. The term of the Loan shall commence on the
date of the Closing and the Loan will mature on the Maturity Date (as defined in
the Note) at which time all outstanding principal, accrued but unpaid interest
thereon and all other sums which may then be owing hereunder, under the Note or
under any of the other Loan Documents shall become due and payable subject to
acceleration or adjustment as provided in the Loan Documents.

        7. BORROWER'S REPRESENTATIONS AND WARRANTIES. Borrower makes the
following representations and warranties to Lender, which representations and
warranties shall be true and correct as of the date of this Agreement, as of the
date of the Closing and on each day during the term of the Loan:

               7.1 AUTHORIZATION AND VALIDITY. The execution and delivery of
this Agreement and each of the documents referenced in this Agreement, which are
to be or have been executed by Borrower, together with the performance of this
Agreement in accordance with its terms, are duly authorized and are not in
contravention of law or of any agreement or undertaking to which Borrower is a
party or by which it is bound, and are in all respects legal, valid, binding and
enforceable against Borrower in accordance with their terms.

               7.2 ACCURATE FINANCIAL INFORMATION. Borrower's financial position
reported to Lender fairly presents in all material respects the financial
condition of Borrower. 




                                      -8-
<PAGE>   9

So long as any indebtedness referred to in this Agreement or any other
indebtedness of Borrower to Lender may be outstanding, there will not be any
substantial unfavorable change in such financial position as would, in the
reasonable judgment of Lender, adversely affect the ability of Borrower to repay
any such indebtedness.

               7.3 NO LITIGATION. There is no litigation pending or to the
knowledge of Borrower threatened against it which may materially affect the
Loan, and Borrower is not in default with respect to any order, writ,
injunction, decree, or demand of any court or administrative body of any
governmental unit having jurisdiction of the Borrower or of Borrower's
properties or operations.

               7.4 FEES AND LICENSES. Borrower has paid, prior to delinquency,
any and all license, franchise or other taxes, fees, imports, duties, or
charges, levied, assessed, or imposed upon it, or upon any of its properties of
whatsoever kind or description which are due and payable and which affect the
Property, the Project or Borrower.

               7.5 COMPLIANCE WITH LAWS. All construction, if any heretofore
performed on the Property, has been performed in accordance with any and all
applicable zoning, building, fire, safety, health, environmental and any and all
other local, state or federal laws, ordinances or regulations.

               7.6 MATERIAL INFORMATION. There is no fact which Borrower has not
disclosed to Lender in writing which materially adversely affects or, insofar as
the Borrower can now foresee, will materially and adversely affect the business,
prospects, profits or conditions (financial or otherwise) of the Borrower, the
Property, the Project, or the ability of Borrower to perform any of its
obligations under this Agreement or any of the other Loan Documents or under the
Tokai Loan Documents.

        8.     EVENTS OF DEFAULT.

               8.1 EVENTS OF DEFAULT. The existence of any one or more of the
following after written notice to Borrower and passage of any cure period which
may be provided in the Loan Documents therefor shall constitute an event of
default hereunder ("Event of Default"):

                      8.1.1  The failure by Borrower to make any payment
promptly when due under the Note or any of the other Loan Documents; or

                      8.1.2  The failure by Borrower to perform any obligation 
when due or abide by any covenants, agreements, representation or warranty
contained in this Agreement, the Note or any of the other Loan Documents; or



                                      -9-
<PAGE>   10

                      8.1.3  The fraud or malfeasance of Borrower in 
constructing the Project or in the use or application of any proceeds of the
Tokai Loan, the Permanent Loan or the Loan; or

                      8.1.4  The falsity in any material respect of any 
representation or warranty by Borrower to Lender contained in this Agreement, in
any of the other Loan Documents, or in any document delivered by Borrower to
Lender pursuant to the terms hereof; or

                      8.1.5  The making of any material change in the Plans and
Specifications without the prior written consent of Lender; or

                      8.1.6  The material alteration of the construction 
schedule for the Project as reflected in the Project Budget without the prior
written consent of Lender; or

                      8.1.7  The occurrence of any material adverse change in 
the financial condition of the Borrower as determined by Lender; or

                      8.1.8  The filing of a complaint for receivership against
Borrower or the filing of a voluntary or involuntary petition for bankruptcy or
for reorganization (unless such complaint or petition be released or discharged
within forty-five (45) days of such filing), or Borrower shall make a general
assignment for the benefit of creditors or consent to the appointment of a
receiver of all or any portion of the collateral given to secure repayment of
the Loan, or voluntarily suspends its usual business; or

                      8.1.9  An unauthorized lien or encumbrance that is not 
removed or for which adequate security is not provided to Lender within the time
set forth in this Agreement; or

                      8.1.10 The occurrence of a breach or an event of default
under any one or more of the Tokai Loan Documents;

                      8.1.11 The occurrence of a breach or an event of default
by Borrower under the Lease; or

                      8.1.12 The default by Borrower under any commitment for
permanent financing of the Project.

               8.2 CURE PERIOD. During the cure period, if any, as may be
provided in the Loan Documents for the subject Event of Default, Borrower shall
take such actions as will cure the Event of Default as specified in such notice;
provided, however, that if the Event of Default described in such notice is the
failure by Borrower to make a payment, the cure shall 



                                      -10-
<PAGE>   11

include prompt delivery of the overdue payment and any and all late charges and
interest thereon.

               8.3 REMEDIES. Upon the occurrence of an Event of Default, Lender
may, in its sole and absolute discretion, declare all outstanding principal
amounts of the Loan, all accrued but unpaid interest thereon and any other
amounts which may be owing under the Loan Documents to be immediately due and
payable notwithstanding any stated maturity dates therefor and pursue any one or
more of the remedies set forth in this Agreement and the other Loan Documents
concurrently or successively to the fullest extent permissible under applicable
law in addition to all rights and remedies conferred on Lender by law or in
equity. Without limiting the generality of the foregoing, Lender may hold, use,
and disburse any proceeds of the Loan to pay: (i) any and all costs, charges and
expenses (including interest) whatsoever and howsoever incurred in connection
with the Loan; (ii) the cost of construction and completion of any Project
improvements; (iii) any obligation of Borrower to Lender relating to the
Project; and (iv) any person furnishing labor, materials, or services for or in
connection with the construction of the Improvements or the holder of any
unauthorized lien or encumbrance on the Project. Such remedies shall also
include without limitation, at Lender's option, but without any obligation, and
upon at least ten (10) days notice to Borrower, Lender's taking possession of
the Project and proceeding with the completion thereof in accordance with the
approved Plans and Specifications.

        9.     GENERAL.

               9.1 NO PARTNERSHIP. It is the express intent of the parties that
they are Lender and Borrower respectively. Borrower and Lender are neither
partners nor joint venturers. Borrower warrants that it shall make no statement,
orally or in writing, or take or omit any action beyond those actions by
Borrower in performing its duties hereunder which could be implied by an
ordinary, reasonable, prudent third party as evidence of a partnership or joint
venture with Lender. Borrower agrees to indemnify, defend and hold harmless
Lender from any claim, cause of action, settlement, judgment, award or damage,
including reasonable attorneys' fees and costs, arising from a breach of this
warranty.

               9.2 NONWAIVER. No failure of Lender to enforce its rights,
remedies, or options hereunder shall be deemed to be a waiver of any of its
rights, remedies, or options hereunder or at law, and it may at any time that
such default exists or continues to exist, enforce any or all of its rights,
remedies, and options arising by reason of such default.

               9.3 ATTORNEYS' FEES. Borrower agrees to pay Lender's attorneys'
fees and costs incurred in connection with the transaction contemplated herein,
including without limitation, such fees and costs incurred in the negotiation of
the Loan Documents and/or one Tokai Loan Documents. In the event either party
breaches any term of this Agreement, or any of the Loan Documents, and if a suit
be brought to enforce any one or more of the Loan Documents, the nonprevailing
party agrees to pay all reasonable costs thereof to the prevailing 


                                      -11-
<PAGE>   12

party, including attorneys' fees and expert witness fees. Said costs and fees
shall include, without limitation, costs and attorneys' fees incurred in any
appeal or in any bankruptcy proceedings or state receivership.

               9.4 LOAN ADMINISTRATION EXPENSES. Borrower shall pay to Lender,
on demand, from time to time, all attorneys' fees and out-of-pocket expenses
incurred by Lender in connection with the administration of the Loan, including,
without limitation, all filing fees, recording fees, release or reconveyance
fees and title insurance premiums.

               9.5 FINANCIAL STATEMENTS. Borrower shall provide to Lender, from
time to time, within thirty (30) days after written request of Lender during the
term of the Loan, a statement of income and expenses of the Project, and a
balance sheet and statement of cash flow of Borrower each in reasonable detail
and certified by Borrower, and if Lender shall require, by an independent
certified public accountant.

               9.6 NOTICE. Any notice or demand that either party desires to
give to the other shall be in writing and either delivered personally or by
first-class mail addressed as follows:

                      To Lender:

                      Neurocrine Biosciences, Inc.
                      3050 Science Park Road
                      San Diego, California 92121
                      Attn: Paul W. Hawran

                      With a Copy To:

                      Wilson Sonsini Goodrich & Rosati
                      650 Page Mill Road
                      Palo Alto, California 94304
                      Attn:  Lauren I. Boro, Esq.

                      To Borrower:

                      Science Park Center LLC
                      4350 La Jolla Village Drive, Suite 930
                      San Diego, CA  92122
                      Attn:  Mr. Michael J. Reidy



                                      -12-
<PAGE>   13


                      With a Copy To:

                      Sullivan Wertz McDade & Wallace
                      945 Fourth Avenue
                      San Diego, CA  92101
                      Attn:  Leo Sullivan, Esq.

                      Wilson Sonsini Goodrich & Rosati
                      650 Page Mill Road
                      Palo Alto, California 94304
                      Attn:  Lauren I. Boro, Esq.

The parties agree that the delivery and/or receipt of notices by entities or
persons identified above as receiving copies shall not be a pre-requisite to the
effectiveness of any notice. Such additional notices are a matter of courtesy
only and are not a requirement of this Agreement. Either party may change its
address by notifying the other in writing of the change. Any notice or demand
delivered by mail shall be deemed delivered three (3) days after it has been
mailed to Lender or to Borrower as the case may be as provided herein.

               9.7 SINGULAR AND PLURAL. Whenever in this Agreement the context
so requires, the neuter gender shall include the masculine and the feminine, the
singular number shall include the plural, and the plural shall include the
singular, and vice versa as the context may require.

               9.8 CAPTIONS. All section or paragraph division, numbering, and
captions are for convenience of reference only, and shall not affect the
interpretation or construction of this agreement or of any term, condition, or
provision thereof.

               9.9 ENTIRE AGREEMENT; MODIFICATION. This Agreement and the Loan
Documents constitute the entire agreement of the parties and supersede all prior
agreements or understandings. No modification or amendment of this Agreement or
the other Loan Documents shall be effective unless set forth in writing signed
by Lender and Borrower.

               9.10 TIME OF ESSENCE. Time is of the essence of this Agreement
and the other Loan Documents.

               9.11 SEVERABILITY. The invalidity of any one or more covenants,
phrases, clauses, sentences of paragraphs of this Agreement shall not affect the
remaining portions of this Agreement or any part thereof, and the same shall be
construed as if such invalid covenants, phrases, clauses, sentences or
paragraphs, if any, had not been inserted herein.

               9.12 EXHIBITS. The Exhibits attached hereto are incorporated
herein by this reference.




                                      -13-
<PAGE>   14

               9.13 FURTHER ACTIONS. Borrower shall perform such further acts
and execute and deliver such further documents as Lender may request from time
to time to further effectuate the terms of this Agreement or to acquire or
perfect the security interests of Lender contemplated under the Loan Documents.

        IN WITNESS WHEREOF, this Agreement is made and entered into as of the
date first above written.

LENDER:

NEUROCRINE BIOSCIENCES, INC.
a Delaware corporation

By: /s/ PAUL W. HAWRAN
    --------------------------------------
        Paul W. Hawran
        Senior Vice President


BORROWER:

SCIENCE PARK CENTER LLC
A California Limited Liability Company

By Nexus Properties, Inc.
A California Corporation
Manager

By: /S/ MICHAEL J. REIDY
    --------------------------------------
        Michael J. Reidy
        Chief Executive Officer

By Neurocrine Biosciences, Inc.
A Delaware Corporation
Manager

By: /s/ PAUL W. HAWRAN
    --------------------------------------
        Paul W. Hawran
        Senior Vice President




                                      -14-
<PAGE>   15

                                LIST OF EXHIBITS



<TABLE>
<S>                                                        <C>
Exhibit "A"................................................Property Description

Exhibit "B"......................................................Project Budget

Exhibit "C"......................................................Loan Documents

Exhibit "D"................................................Permitted Exceptions
</TABLE>





                                      -15-
<PAGE>   16

                                   EXHIBIT "A"

                              Property Description


LOT 30 OF TORREY PINES SCIENCE CENTER UNIT NO. 2, IN THE CITY OF SAN DIEGO,
COUNTY OF SAN DIEGO, STATE OF CALIFORNIA, ACCORDING TO MAP THEREOF NO. 12845,
FILED IN THE OFFICE OF THE COUNTY RECORDER OF SAN DIEGO COUNTY ON JULY 23, 1991.





                                      -16-
<PAGE>   17

                                   EXHIBIT "B"

                                 Project Budget





                                      -17-
<PAGE>   18
                                   NEUROCRINE
                              *** SF R&D FACILITY
                           PRELIMINARY COST PRO FORMA
                                      ***

<TABLE>
<S>                                                  <C>            <C>

                                      ***

</TABLE>

*  confidential treatment
<PAGE>   19

                                   EXHIBIT "C"

                                 Loan Documents

1.      The Agreement;

2.      The Note;

3.      The Lender Deed of Trust;

4.      The Lender Assignment of Contracts;

5.      Any and all UCC-1 Financing Statements required by Lender;

6.      The Assignment;

7.      The Option Agreement;

8.      A Memorandum of the Option Agreement in recordable form;

9.      The Lease;

10.     A Memorandum of the Lease in recordable form;

11.     Such other and further documents and instruments as may be reasonably
        required by Lender as a condition to the Closing; and

12.     Any and all amendments, modifications or substitutions of the above
        listed documents and instruments as may be requested or expressly
        approved by Lender.




                                      -18-
<PAGE>   20

                                   EXHIBIT "D"

                              Permitted Exceptions









                                      -19-

<PAGE>   21

                       [CHICAGO TITLE COMPANY LETTERHEAD]


TRISH ERICKSON
CHICAGO TITLE/SAN DIEGO           Order No.   007353168  13
925 B STREET                      Reference:
SAN DIEGO, CA 92101               Regarding:  LOT, TORREY PINES SCIENCE CENTER
                                              SAN DIEGO, CA

Dated as of June 6, 1997   at 7:30 AM

In response to the above referenced application for a policy of title insurance,

                             CHICAGO TITLE COMPANY

hereby reports that it is prepared to issue, or cause to be issued, as of the 
date hereof, a Policy or Policies of Title Insurance describing the land and
the estate or interest therein hereinafter set forth, insuring against loss
which may be sustained by reason of any defect, lien or encumbrance not shown
or referred to as an Exception in Schedule B or not excluded from coverage
pursuant to the printed Schedules, Conditions and Stipulations of said Policy
forms.

The printed Exceptions and Exclusions from the coverage of said Policy or
Policies are set forth in Exhibit A attached list.  Copies of the Policy forms
should be read.  They are available from the office which issued the report.

Please read the exceptions shown or referred to in Schedule B and the exceptions
and exclusions set forth in Exhibit A of this report carefully.  The exceptions
and exclusions are meant to provide you with notice of matters which are not
covered under the terms of the title insurance policy and should be carefully
considered.

It is important to note that this preliminary report is not a written
representation as to the condition of title and may not list all liens,
defects, and encumbrances affecting title to the land.

THIS REPORT (AND ANY SUPPLEMENTS OR AMENDMENTS HERETO) IS ISSUED SOLELY FOR THE
PURPOSE OF FACILITATING THE ISSUANCE OF A POLICY OF TITLE INSURANCE AND NO
LIABILITY IS ASSUMED HEREBY, IF IT IS  DESIRED THAT LIABILITY BE ASSUMED PRIOR
TO THE ISSUANCE OF A POLICY OF TITLE INSURANCE, A BINDER OR COMMITMENT SHOULD
BE REQUESTED.

The form of policy of title insurance contemplated by this report is:

     CALIFORNIA LAND TITLE INSURANCE ASSOCIATION STANDARD COVERAGE POLICY
     AMERICAN LAND TITLE ASSOCIATION LOAN STANDARD COVERAGE POLICY

/s/      KEN CYR
- ------------------------
Title Officer KEN CYR
<PAGE>   22
                                   SCHEDULE A

Order No: 7353168  13                Your Ref:


1.   The estate or interest in the land hereinafter described or referred to
     covered by this report is:

A FEE






2.   Title to said estate or interest at the date hereof is vested in:

NEUROCRINE BIOSCIENCES, INC., A DELAWARE CORPORATION







3.   The land referred to in this report is situated in the State of
     California, County of SAN DIEGO and is described as follows:

     LOT 30 TORREY PINES SCIENCE CENTER, UNIT NO. 2, IN THE CITY OF SAN DIEGO,
COUNTY OF SAN DIEGO, STATE OF CALIFORNIA, ACCORDING TO MAP THEREOF NO. 12845,
FILED IN THE OFFICE OF THE COUNTY RECORDER OF SAN DIEGO, COUNTY, JULY 23, 1991.
<PAGE>   23
                                   SCHEDULE B
Page 1
Order No: 7353168  13               Your Ref:

At the date hereof exceptions to coverage in addition to the printed Exceptions
and Exclusions in the policy form designated on the face page of this Report
would be as follows:

A    1.   PROPERTY TAXES, INCLUDING ANY ASSESSMENTS COLLECTED WITH TAXES, TO BE
          LEVIED FOR THE FISCAL YEAR 1997-98 THAT ARE A LIEN NOT YET DUE.

B    2.   THE LIEN OF SUPPLEMENTAL OR ESCAPED ASSESSMENTS OF PROPERTY TAXES, IF
          ANY, MADE PURSUANT TO THE PROVISIONS OF PART 0.5, CHAPTER 3.5 OR PART
          2, CHAPTER 3, ARTICLES 3 AND 4 RESPECTIVELY (COMMENCING WITH SECTION
          75) OF THE REVENUE AND TAXATION CODE OF THE STATE OF CALIFORNIA AS A
          RESULT OF THE TRANSFER OF TITLE TO THE VESTEE NAMED IN SCHEDULE A; OR
          AS A RESULT OF CHANGES IN OWNERSHIP OR NEW CONSTRUCTION OCCURRING
          PRIOR TO DATE OF POLICY.

C    3.   A COVENANT AND AGREEMENT EXECUTED BY: GENERAL ATOMIC COMPANY, IN
          FAVOR OF: THE CITY OF SAN DIEGO; RECORDED: AUGUST 8, 1979 AS FILE NO.
          79-331888 OF OFFICIAL RECORDS, WHICH AMONG OTHER THINGS PROVIDES: NO
          PROTEST SHALL BE MADE BY THE OWNER(S) TO ANY PROCEEDINGS FOR THE
          INSTALLATION OR ACQUISITION OF: SIDEWALKS UNDER ANY SPECIAL ASSESSMENT
          PROCEEDINGS, WHETHER CONDUCTED PURSUANT TO THE IMPROVEMENT ACT OF 1911
          OR THE MUNICIPAL IMPROVEMENT ACT OF 1913, OR ANY OTHER APPLICABLE
          STATE OR LOCAL LAW, AND WHETHER PROCESSED BY THE CITY OF SAN DIEGO OR
          ANY OTHER GOVERNMENTAL ENTITY HAVING JURISDICTION IN THE MATTER AND
          FOR THE PURPOSES OF DETERMINING PROPERTY OWNER(S) SUPPORT FOR SUCH
          SAME.

D    4.   THE TERMS, CONDITIONS AND PROVISIONS CONTAINED IN CONDITIONAL USE
          PERMIT NO. 17123, AS DISCLOSED BY INSTRUMENT RECORDED JUNE 25, 1981 AS
          FILE NO. 81-199690 OF OFFICIAL RECORDS, AND AS MODIFIED BY AN
          INSTRUMENT RECORDED NOVEMBER 4, 1981 AS FILE NO. 81-350072 OF OFFICIAL
          RECORDS.

E   5.    THE FACT THAT SAID LAND LIES WITHIN THE NORTH UNIVERSITY CITY
          ASSESSMENT DISTRICT PLATT NO. 3971, AS DISCLOSED BY NOTICE OF
          ASSESSMENT RECORDED JUNE 4, 1992 AS FILE NO. 1992-0349304, SEPTEMBER
          16, 1993 AS FILE NO. 1993-0611476 AND AUGUST 9, 1994 AS FILE NO.
          1994-0485273, ALL OF OFFICIAL RECORDS.

F    6.   THE FACT THAT SAID LAND LIES WITHIN THE NORTH UNIVERSITY CITY
          ASSESSMENT DISTRICT PLATT NO. 3971, AS DISCUSSED BY NOTICE OF
          ASSESSMENT RECORDED FEBRUARY 17, 1982 AS FILE NO. 82-043183 OF
          OFFICIAL RECORDS, AND AMENDED NOTICE OF ASSESSMENT RECORDED NOVEMBER
          29, 1982 AS FILE NO. 82-365411 AND JUNE 20, 1985 AS FILE NO.
          85-228199, OCTOBER 1, 1991 AS FILE NO. 1991-0506424, AUGUST 11, 1989
          AS FILE NO. 89-430633 AND JUNE 4, 1992 AS FILE NO. 1992-0349393, ALL
          OF OFFICIAL RECORDS.  AN ASSESSMENT DISTRICT
<PAGE>   24
                                   SCHEDULE B
                                  (continued)
Page 2
Order No: 7353168  13               Your Ref:

          DIAGRAM RECORDED FEBRUARY 17, 1982 AS FILE NO. 82-043184 OF OFFICIAL
          RECORDS. AN AMENDED ASSESSMENT DISTRICT DIAGRAM RECORDED NOVEMBER 29,
          1982 AS FILE NO. 82-365410, NOVEMBER 29, 1983 AS FILE NO. 83-430939
          AND JUNE 26, 1985 AS FILE NO. 85-228195 AND OCTOBER 1, 1991 AS FILE
          NO. 1991-0506423, JUNE 4, 1992 AS FILE NO. 1992-0349304 AND DEPARTMENT
          OF THE TREASURY, INTERNAL REVENUE SERVICE, SPECIAL PROCEDURES STAFF,
          P.O. BOX 30223, LAGUNA NIGUEL, CA 92607-0223, ATTN: J. KING 16, 1993
          AS FILE NO. 1993-0611476, ALL OF OFFICIAL RECORDS.

G    7.   COVENANTS CONDITIONS AND RESTRICTIONS (BUT OMITTING THEREFROM ANY

          COVENANT OR RESTRICTION BASED ON RACE, COLOR, RELIGION, SEX, HANDICAP,
          FAMILIAL STATUS OR NATIONAL ORIGIN, IF ANY, UNLESS AND ONLY TO THE
          EXTENT THAT SAID COVENANT (A) IS EXEMPT UNDER CHAPTER 42, SECTION 3607
          OF THE UNITED STATES CODE OR (B) RELATES TO HANDICAP BUT DOES NOT
          DISCRIMINATE AGAINST HANDICAPPED PERSONS) AS SET FORTH IN THE
          DOCUMENT.

          RECORD:        JULY 16, 1986 AS FILE NO. 86-293105 OF OFFICIAL
                         RECORDS


H    8.   AN EASEMENT FOR ROADWAY AND INCIDENTAL PURPOSES AS SET FORTH IN THE
          INSTRUMENT-ABOVE MENTIONED.

          AN EASEMENT FOR THE INSTALLATION AND MAINTENANCE OF UTILITIES AND 
          INCIDENTAL PURPOSES AS SET FORTH IN THE INSTRUMENT ABOVE MENTIONED.

          THE ROUTE OF SAID EASEMENT CANNOT BE DETERMINED FROM THE RECORD.

I    9.   THE TERMS, CONDITIONS AND PROVISIONS CONTAINED IN PLANNED INDUSTRIAL
          DEVELOPMENT PERMIT NO. 86-0884, AS DISCLOSED BY INSTRUMENT RECORDED
          DECEMBER 22, 1988 AS FILE NO. 88-658676, AND MAY 30, 1989 AS FILE NO.
          89-283953, BOTH OF OFFICIAL RECORDS.

J   10.   A REVISED CONDITIONS AND FINDINGS OF THE CALIFORNIA COASTAL COMMISSION
          DISCLOSED IN DOCUMENTS RECORDED JULY 13, 1989 AS FILE NO. 89-370153
          AND FEBRUARY 5, 1991 AS FILE NOS. 1991-0050777 AND 1991-0050778, ALL
          OF OFFICIAL RECORDS. 

          REFERENCE IS MADE TO SAID DOCUMENT FOR FULL PARTICULARS.

K   11.   A DEED RESTRICTION FOR OPEN SPACE AND THE TERMS, COVENANTS,
          CONDITIONS AND RESTRICTIONS CONTAINED THEREIN, RECORDED FEBRUARY 5,
          1991 AS FILE NO. 1991-0050778 OF OFFICIAL RECORDS. 
<PAGE>   25
                                   SCHEDULE B
                                  (continued)
Page 3
Order No: 7353168  13               Your Ref:

L    12.  AN EASEMENT FOR THE PURPOSE SHOWN BELOW AND RIGHTS INCIDENTAL THERETO
          AS SHOWN OR AS OFFERED FOR DEDICATION ON THE RECORDED MAP SHOWN BELOW.

          MAP OF:             12845
          EASEMENT
            PURPOSE:          DRAINAGE AND INCIDENTAL PURPOSES
          AFFECTS:            LOT 30

N    13.  AN EASEMENT, AND THE TERMS AND CONDITIONS AS CONTAINED THEREIN

          DATED:              NOT SHOWN
          BY AND BETWEEN:     THE CITY OF SAN DIEGO AND CHEVRON LAND AND
                              DEVELOPMENT COMPANY
          RECORDED:           JULY 25, 1991 AS FILE NO. 1991-0366277 OF
                              OFFICIAL RECORDS
          REGARDING:          INSTALLATION, MAINTENANCE AND POSSIBLE REMOVAL OF
                              STORM DRAIN

          AFFECTS LOT 30.

M    14.  AN EASEMENT, AND THE TERMS AND CONDITIONS AS CONTAINED THEREIN

          DATED:              NOT SHOWN
          BY AND BETWEEN:     THE CITY OF SAN DIEGO AND CHEVRON LAND AND
                              DEVELOPMENT COMPANY
          RECORDED:           JULY 25, 1991 AS FILE NO. 1991-0366280 OF
                              OFFICIAL RECORDS
          REGARDING:          INSTALLATION, MAINTENANCE AND POSSIBLE REMOVAL OF
                              LANDSCAPING AND IRRIGATION LINES, ENHANCED
                              PAVEMENT, BRIDGE LIGHTING AND LANDSCAPE LIGHTING
                              OVER AND ACROSS PUBLIC RIGHT OF WAY-CANYON BRIDGE
                              DR/GENESEE AVE.


          AFFECTS SAID LAND AS SHOWN IN PLAT ATTACHED THERETO.

          REFERENCE IS MADE TO SAID INSTRUMENT FOR FURTHER PARTICULARS.


O    15.  THE LIMITATIONS, COVENANTS, CONDITIONS, RESTRICTIONS, RESERVATIONS,
          EASEMENTS, TERMS, LIENS, ASSESSMENTS, PROVISIONS AND CHARGES BUT
          DELETING RESTRICTIONS, IF ANY, BASED ON RACE, COLOR, RELIGION OR
          NATIONAL ORIGIN AS CONTAINED IN THE DECLARATION OF RESTRICTIONS
          RECORDED AUGUST 28, 1991 AS FILE NO. 1991-0440869 OF OFFICIAL RECORDS.

          AN ASSIGNMENT AND ASSUMPTION OF DECLARANT'S RIGHTS AND OBLIGATIONS
          FROM CHEVRON LAND AND DEVELOPMENT COMPANY, A DELAWARE CORPORATION TO
          M.S. VICKERS II, LLC. A DELAWARE LIMITED LIABILITY COMPANY RECORDED
          MAY 10, 1996 AS FILE NO. 1996-0238566, OFFICIAL RECORDS.

P    16.  AN IMPROVEMENT FINANCING AGREEMENT DATED JULY 22, 1991, UPON THE
          TERMS, CONVENANTS, AND CONDITIONS CONTAINED THEREIN.
<PAGE>   26
                                   SCHEDULE B
                                  (continued)
Page 4
Order No: 7353168  13               Your Ref:

          EXECUTED BY
          AND BETWEEN    CHEVRON LAND AND DEVELOPMENT COMPANY, A DELAWARE
                         CORPORATION AND THE CITY OF SAN DIEGO, A MUNICIPAL
                         CORPORATION
          RECORDED:      SEPTEMBER 4, 1991 AS FILE NO. 1991-0453349 OF OFFICIAL
                         RECORDS.

          REFERENCE IS MADE TO SAID INSTRUMENT FOR FURTHER PARTICULARS.

Q.   17.  AN EASEMENT FOR THE PURPOSE SHOWN BELOW AND RIGHTS INCIDENTAL THERETO
          AS SET FORTH IN A DOCUMENT

          GRANTED TO:    SAN DIEGO GAS AND ELECTRIC COMPANY
          PURPOSE:       UNDERGROUND FACILITIES AND APPURTENANCES FOR THE
                         TRANSMISSION AND DISTRIBUTION OF ELECTRICITY,
                         PIPELINES, COMMUNICATION FACILITIES, AND APPURTENANCES
                         AND GRANTEE ALSO HAS THE RIGHT OF INGRESS AND EGRESS
                         FROM AND ALONG THIS EASEMENT AND INCIDENTAL PURPOSES 
          RECORDED:      JUNE 23, 1993 AS FILE NO. 1993-0396204 OF OFFICIAL
                         RECORDS, DESCRIBED AS FOLLOWS:

                         SAID EASEMENT SHALL BE A STRIP OF LAND, INCLUDING ALL
                         OF THE AREA LYING BETWEEN THE EXTERIOR SIDELINES, WHICH
                         SIDELINES SHALL BE 3 FEET, MEASURED AT RIGHT ANGLES, ON
                         EACH EXTERIOR SIDE OF EACH AND EVERY FACILITY INSTALLED
                         WITH SAID PROPERTY ON OR BEFORE DECEMBER 31, 1995.

                         THE ROUTE OR LOCATION OF SAID EASEMENT CANNOT BE
                         DETERMINED FROM THE RECORD.

                         REFERENCE IS MADE TO SAID INSTRUMENT FOR FURTHER
                         PARTICULARS.

R    18.  THE LIMITATIONS, COVENANTS, CONDITIONS, RESTRICTIONS, RESERVATIONS,
          EASEMENTS, TERMS, LIENS, ASSESSMENTS, PROVISIONS AND CHARGES BUT
          DELETING RESTRICTIONS, IF ANY, BASED ON RACE, COLOR, RELIGION OR
          NATIONAL ORIGIN AS CONTAINED IN THE DECLARATION OF RESTRICTIONS
          RECORDED JUNE 27, 1994 AS FILE NO. 1994-0405385 OF OFFICIAL RECORDS.

          SAID INSTRUMENT ALSO PROVIDES THAT ALL LIENS CREATED BY THIS
          DECLARATION OF RESTRICTIONS, INCLUDING BUT NOT LIMITED TO, ANY REGULAR
          OR SPECIAL ASSESSMENTS FOR THE PAYMENT OF MONEY, SHALL BE SUBORDINATE
          TO THE LIEN CREATED BY ANY FIRST DEED OF TRUST OR FIRST MORTGAGE.

          SAID INSTRUMENT PROVIDES THAT A VIOLATION THEREOF SHALL NEITHER
          DEFEAT NOR RENDER INVALID THE LIEN OF ANY MORTGAGE OR DEED OF TRUST
          MADE FOR VALUE.
<PAGE>   27
                                  SCHEDULE B
                                  (Continued)

Page 5
Order No. 7353168   13                             Your Ref:

          AN ASSIGNMENT AND ASSUMPTION OF DECLARANT'S RIGHTS AND OBLIGATIONS
          FROM CHEVRON LAND AND DEVELOPMENT COMPANY, A DELAWARE CORPORATION TO
          M.S. VICKERS II, LLC A DELAWARE LIMITED LIABILITY COMPANY RECORDED MAY
          10, 1996 AS FILE NO. 1996-0238566, OFFICIAL RECORDS.

S    19.  RIGHTS OF PARTIES IN POSSESSION OF SAID LAND.
          MATTERS AFFECTING THE RIGHTS OF SAID PARTIES ARE NOT SHOWN HEREIN.

T    20.  MATTERS WHICH MAY BE DISCLOSED BY AN INSPECTION OR SURVEY OF SAID
          LAND OR BY INQUIRY OF THE PARTIES IN POSSESSION THEREOF.

U         END OF SCHEDULE B

Z         NOTE NO. 1:  PROPERTY TAXES FOR THE FISCAL YEAR SHOWN BELOW ARE PAID.
          FOR INFORMATION PURPOSES THE AMOUNTS ARE:


          FISCAL YEAR:        1996-1997
          1ST INSTALLMENT:    $5,003.76
          2ND INSTALLMENT:    $5,003.76
          EXEMPTION:          $ NONE
          CODE AREA:           08118
          ASSESSMENT NO.:      340-180-20

AA        NOTE NO. 2:  SUPPLEMENTAL OR ESCAPED TAXES FOR THE FISCAL YEAR
          1996-1997, ASSESSED PURSUANT TO THE PROVISIONS OF CHAPTER 3.5
          (COMMENCING WITH SECTION 75) OF THE REVENUE AND TAXATION CODE OF THE
          STATE OF CALIFORNIA.

          1ST INSTALLMENT     $245.22  (PAID)
          2ND INSTALLMENT:    $245.22  (PAID)
          CODE AREA:            08118
          ASESSMENT NO.:        859-341-98-35

          SUPPLEMENTAL OR ESCAPED TAXES FOR THE FISCAL YEAR 1996-1997, ASSESSED
          PURSUANT TO THE PROVISIONS OF CHAPTER 3.5 (COMMENCING WITH SECTION 75)
          OF THE REVENUE AND TAXATION CODE OF THE STATE OF CALIFORNIA.

          1ST INSTALLMENT     $3,011.17  (PAID)
          2ND INSTALLMENT     $3,011.17  (PAID)
          CODE AREA:            08118
          ASSESSMENT NO.:       869-341-98-26

V         NOTE NO. 3:  THIS COMPANY WILL REQUIRE THE FOLLOWING IN ORDER TO
          INSURE TITLE IN, OR A CONVEYANCE FROM, THE ENTITY NAMED BELOW.

          NAME:  NEUROCRINE BIOSCIENCE, INC.



     
<PAGE>   28
                                   SCHEDULE B
                                  (continued)
Page 6
Order No: 7353168  13               Your Ref:

          A COPY OF THE RESOLUTION OF THE CORPORATION APPROVING THE PRESENT
          TRANSACTION AND IDENTIFYING THE SUBJECT LAND.

W         NOTE NO. 4: YOUR OPEN ORDER TRUST REQUEST INDICATES THAT A LIMITED
          LIABILITY COMPANY WILL BE ACQUIRING, ENCUMBERING OR CONVEYING REAL
          PROPERTY IN YOUR TRANSACTION.  UNDER THE PROVISIONS OF "THE CALIFORNIA
          LIMITED LIABILITY ACT, EFFECTIVE SEPTEMBER 30, 1994" THE FOLLOWING
          WILL BE REQUESTED:

          1.   A COPY OF THE ARTICLES OF ORGANIZATION (AND ALL AMENDMENTS, IF
          ANY) THAT HAS BEEN FILED WITH THE SECRETARY OF STATE.

          2.   THE REQUIREMENT THAT THIS COMPANY BE PROVIDED WITH A COPY OF THE
          OPERATING AGREEMENT.  THE COPY PROVIDED MUST BE CERTIFIED BY THE
          APPROPRIATE MANAGER OR MEMBER THAT IT IS A COPY OF THE CURRENT
          OPERATING AGREEMENT.

          3.   IF THE LIMITED LIABILITY COMPANY IS MEMBER-MANAGED THEN THIS
          COMPANY MUST BE PROVIDED WITH A CURRENT LIST OF THE MEMBER NAMES.

X         NOTE:  IF THIS COMPANY IS REQUESTED TO DISBURSE FUNDS IN CONNECTION
          WITH THIS TRANSACTION, CHAPTER 598, STATUTES OF 1989 MANDATES HOLD
          PERIODS FOR CHECKS DEPOSITED TO ESCROW OR SUB-ESCROW ACCOUNTS.  THE
          MANDATORY HOLD PERIOD FOR CASHIER'S CHECKS, CERTIFIED CHECKS AND
          TELLER'S CHECKS IS ONE BUSINESS DAY AFTER THE DAY DEPOSITED.  OTHER
          CHECKS REQUIRE A HOLD PERIOD FROM THREE TO SEVEN BUSINESS DAYS AFTER
          THE DAY DEPOSITED.

Y         EH
<PAGE>   29
                       [CHICAGO TITLE COMPANY LETTERHEAD]

SUPPLEMENTAL REPORT                     ISSUING OFFICE:
                                        925 "B" STREET
                                        SAN DIEGO, CA 92101



TRISH ERICKSON
CHICAGO TITLE/SAN DIEGO
925 B STREET
SAN DIEGO, CA 92101



Your Ref:                          Order No: 7353168   13

Dated as of JUNE 16,1997    at 7:30 AM

/s/   KEN CYR
- ------------------
Title Officer: KEN CYR


The above numbered report dated JUNE 6, 1997 (including any supplements or
amendments thereto) is hereby modified and/or supplemented in order to reflect
the following:


PLEASE AMEND/MODIFY ITEM NO(S) 6 TO READ AS FOLLOWS:

THE FACT THAT SAID LAND LIES WITHIN THE NORTH UNIVERSITY CITY ASSESSMENT
DISTRICT PLATT NO. 3971, AS DISCLOSED BY NOTICE OF ASSESSMENT RECORDED FEBRUARY
17, 1982 AS FILE NO. 82-043183 OF OFFICIAL RECORDS, AND AMENDED NOTICE OF
ASSESSMENT RECORDED NOVEMBER 29, 1982 AS FILE NO. 82-365411 AND JUNE 26, 1985 AS
FILE NO. 85-228199, OCTOBER 1, 1991 AS FILE NO. 1991-0506424, AUGUST 11, 1989 AS
FILE NO. 89-430633 AND JUNE 4, 1992 AS FILE NO. 1992-0349303, ALL OF OFFICIAL
RECORDS.  AN ASSESSMENT DISTRICT DIAGRAM RECORDED FEBRUARY 17, 1982 AS FILE NO.
82-043184 OF OFFICIAL RECORDS.  AN AMENDED ASSESSMENT DISTRICT DIAGRAM RECORDED
NOVEMBER 29, 1992 AS FILE NO. 82-365410, NOVEMBER 29, 1983 AS FILE NO. 83-430939
AND JUNE 26, 1985 AS FILE NO. 85-228195 AND OCTOBER 1, 1991 AS FILE NO.
1991-0506423, JUNE 4, 1992 AS FILE NO. 1992-0349304 AND DEPARTMENT OF THE
TREASURY, INTERNAL REVENUE SERVICE, SPECIAL PROCEDURES STAFF, P.O. BOX 30223,
LAGUNA NIGUEL, CA 92607-0223, ATTN: J. KING 16, 1993 AS FILE NO. 1993-0611476,
ALL OF OFFICIAL RECORDS. 
<PAGE>   30
                       [CHICAGO TITLE COMPANY LETTERHEAD]


JUNE 17, 1997




MS. TRISH ERICKSON
CHICAGO TITLE COMPANY
925 B STREET
SAN DIEGO, CA 92101

RE:  ESCROW NO. 7353168-U48
TITLE ORDER NO. 7353168-U13

DEAR TRISH:

SUPPLEMENTING OUR PRELIMINARY REPORT DATED AS OF JUNE 6, 1997; WE WISH TO
ADVISE YOU OF THE FOLLOWING:

NEW EXCEPTION NO. 21 IS HEREBY ADDED TO SCHEDULE B:

21.  ANY CLAIMS FOR MECHANIC'S LIENS ON SAID LAND THAT MAY BE RECORDED BY
REASON OF A WORK OF IMPROVEMENT DISCLOSED BY AN INSPECTION OF SAID LAND.

PLEASE NOTE THAT AT THE TIME OF INSPECTION, THERE WAS A CONSTRUCTION EQUIPMENT
STORED ON THE SITE AS WELL AS A SIGN PLACED ON A CONSTRUCTION/SECURITY FENCE
WITH A SIGN FOR R.E. HAZARD CONSTRUCTION COMPANY.

SHOULD YOU HAVE ANY QUESTIONS, PLEASE DO NOT HESITATE TO CALL.


SINCERELY,

  /s/  Ken Cyr
- ----------------------------
KEN CYR
COMMERCIAL/INDUSTRIAL
TITLE OFFICER
 

<PAGE>   1
                                                                    EXHIBIT 10.4

                             SECURED PROMISSORY NOTE


$3,840,000.00 + Additional Advances                      San Diego, California
                                                                 July 31, 1997


           FOR VALUE RECEIVED, SCIENCE PARK CENTER LLC, a California limited
liability company ("Borrower"), promises to pay, in lawful money of the United
States of America, to the order of NEUROCRINE BIOSCIENCES, INC., a Delaware
corporation ("Lender"), at 3050 Science Park Road, San Diego, California 92121,
or at such other place as Lender may designate in writing from time to time, the
principal sum of Three Million Eight Hundred Forty Thousand Dollars
($3,840,000.00) or so much thereof as shall be from time to time disbursed
hereunder, plus such additional advances as may be made pursuant to the terms of
the Loan Agreement (as defined below), with interest on the disbursed but unpaid
principal balance payable at the rate and in the manner provided below (the
"Loan"). This Secured Promissory Note (this "Note") is the promissory note
referred to in the Construction Loan Agreement of even date herewith between
Lender and Borrower (the "Loan Agreement") and is subject to the terms of the
Loan Agreement and is entitled to the benefits of the security interests and
collateral described therein. Initially capitalized terms used in this Note
without definition have the meanings given them in the Loan Agreement.

           1. Interest. Interest shall accrue on the disbursed but unpaid
principal balances hereof from the date of disbursement until paid at the rate
of eight and one-quarter percent (8.25%) per annum. Interest for a portion of
any month shall be calculated on the basis of the actual number of days in the
period for which the calculation is being made.

           2. Repayment. Interest accrued on outstanding principal hereunder
from the date hereof through and including the Term Commencement Date (as
defined below) shall be added to principal on the Term Commencement Date, at
which time the total outstanding principal, with interest thereon calculated
pursuant to Section 1 above, shall be amortized over a ten (10) year period and
principal and interest shall be payable in equal monthly installments beginning
on the Term Commencement Date and thereafter on the first day of each succeeding
calendar month and continuing until the Maturity Date (defined below) at which
time the entire unpaid principal balance hereunder, together with all accrued
but unpaid interest thereon, and all other sums owing under the other Loan
Documents, shall be due and payable in full. The Term Commencement Date is the
date defined in the Lease as the Term Commencement Date. The Maturity Date is
the date which is the tenth (10th) anniversary of the Term Commencement Date.
Each payment shall be credited first to the payment of any late charges or costs
due hereunder, then to the payment of any interest then due and the remainder
shall be credited to principal.

                                      -1-
<PAGE>   2

           3. Adjustment to Repayment. Lender and Borrower acknowledge that the
monthly installments of Basic Annual Rent (as defined in the Lease) to be paid
by Lender (the "Monthly Rent"), as tenant, to Borrower, as landlord, under the
Lease during an initial period of approximately three (3) years (the ?Shortfall
Period?) following the Term Commencement Date will not, in all likelihood, be
enough to fund Borrower's monthly payment obligation with respect to (i) the
Permanent Loan, (ii) the Loan, (iii) fees Borrower is obligated to pay to Nexus
Properties, Inc., a California corporation, pursuant to Section 8.3 of
Borrower's Operating Agreement (the "Nexus Fees"), and (iv) disbursements to
Nexus Properties, Inc. pursuant to Sections 7.2(i) and (ii) of Borrower's
Operating Agreement ("Nexus Disbursements"). Therefore, notwithstanding the
provisions of Section 2 above, Lender and Borrower agree that the minimum
monthly payment due hereunder for each month during the Shortfall Period, shall
be the lesser of (i) the regularly scheduled payment of principal and interest
as calculated pursuant to Section 2 above (the "Scheduled Monthly Installment"),
or (ii) the balance of the Monthly Rent less (a) that month's regularly
scheduled installment under the Permanent Loan, (b) that month's regularly
scheduled payment of the Nexus Fees, and (c) accrued and unpaid payments of the
Nexus Disbursements. After such the Shortfall Period, Borrower shall be
obligated to pay the Scheduled Monthly Installment each month during the balance
of the scheduled term of this Note (subject to reamortization as provided
herein). After the Shortfall Period, Lender shall have the right, at its
election, to reamortize the total outstanding principal hereunder, with accrued
but unpaid interest thereon calculated pursuant to Section 1 above, over the
remainder of the scheduled term of this Note and Borrower shall repay the
indebtedness evidenced by this Note pursuant to such reamortization. The
provisions of this Section 3 are not intended as a waiver by Lender of repayment
of any principal disbursed hereunder, any interest thereon or any other sums
which may be due hereunder or under the terms of the other Loan Documents. The
adjusted repayment schedule for principal and interest hereunder during the
Shortfall Period the first year of the term of this Note commencing on the Term
Commencement Date shall not affect Borrower's obligations to timely pay any
other costs or expenses in full which may be due pursuant to the terms of this
Note or the other Loan Documents.

           4. Prepayment. Borrower shall not prepay outstanding principal or
other sums due under this Note at any time prior to the full reconveyance of the
Tokai Deed of Trust unless Borrower has received Lender's prior written approval
of such prepayment. Such approval may be given or withheld by Lender in Lender's
sole and absolute discretion. If such approval is given, it shall apply only to
the specific prepayment identified in Lender's written approval. After the full
reconveyance of the Tokai Deed of Trust, the outstanding principal balance of
this Note may be prepaid in whole or in part by Borrower, without premium or
penalty. Lender shall not be obligated to reamortize the repayment schedule for
this Note pursuant to any prepayment unless Lender, in its sole and absolute
discretion, elects to do so.


                                      -2-

<PAGE>   3
           5.  Security.  This Note is secured by the following:

                     5.1       That certain Construction Deed of Trust, 
Assignment of Rents and Leases, Security Agreement and
Fixture Filing executed by Borrower and naming Lender as beneficiary, delivered
by Borrower concurrently herewith the ("Deed of Trust") which, as of the date
hereof, shall be second in priority to the Tokai Deed of Trust;

                     5.2       Financing Statement(s) covering the chattels, 
fixtures, equipment and general intangibles installed or used in connection with
the Project; and

                     5.3       That certain Assignment of Contracts, Licenses, 
Permits, Agreements, Warranties, Plans and Specifications executed by Borrower
in favor of Lender, delivered by Borrower concurrently herewith (the
"Assignment").

           6.  Default.

                     6.1       Events of Default. The occurrence of any one or 
more of the following shall be an event of default Under this Note ("Event of
Default"):

                               6.1.1      Borrower's  failure to make any 
payment promptly when due of principal and/or interest, or any other sums due
under any one or more of (a) the Loan Agreement, (b) this Note, (c) the Deed of
Trust, (d) the Assignment, (e) the other Loan Documents, or (f) any other
document or instrument executed by Borrower securing payment of, or otherwise in
any way in connection with, this Note (which includes the documents referred to
in Section 6.1.1.);

                               6.1.2      The failure of Borrower to perform 
any of its obligations or to make any payments promptly when due of principal,
interest, or other sums due under any one or more of the Tokai Loan Documents or
any loan documents executed by Borrower in connection with the Tokai Loan and/or
the Permanent Loan or any other documents or instruments executed by Borrower
with, or in favor of, any other construction lender for any loan obtained by
Borrower in connection with the Project (collectively, with all of the documents
and instruments referenced in Section 6.1.1 above, the "Documents");

                               6.1.3      An event of default under any one or 
more of the Documents;

                               6.1.4      An event of default by Borrower under
the Lease; or

                               6.1.5      The occurrence or non-occurrence of 
an event described in Section 4.2 of the Lease which would entitle Lender to
terminate the Lease pursuant to said Section 4.2.


                                      -3-
<PAGE>   4
                     6.2       Remedies.  Upon an Event of Default, then in 
addition to any other rights or remedies available to Lender, Lender
may, at its option, declare the entire outstanding principal balance hereunder
and accrued but unpaid interest hereunder, and all other amounts and/or payments
due hereunder, and/or under the other Loan Documents, immediately due and
payable notwithstanding any stated maturity date therefor and such amounts shall
then be immediately due and payable. If an Event of Default occurs, and Lender
elects to accelerate the Loan, or in the event that this Note is not paid in
full on the Maturity Date, interest thereafter on the unpaid principal balance,
accrued interest and costs incurred shall be payable at the rate set forth in
Section 1 above plus five percent (5%) per annum. If an Event of Default occurs,
Lender may also pursue any other rights or remedies provided hereunder, in any
of the other Loan Documents or conferred upon Lender at law or in equity.
Borrower agrees that acceptance by Lender of any performance which does not
strictly comply with the terms of this Note shall not be deemed to be a waiver
of any of Lender's rights hereunder.

                     6.3       Late Payment.  Borrower recognizes that any 
default in making any payments when due herein will result in Lender incurring
additional expense in servicing the Loan not contemplated hereunder, the exact
amount of which will be extremely difficult to ascertain. Such expense will
include, but not be limited to, processing and accounting charges, in addition
to the loss to Lender of the use of money due, and in frustration to Lender in
meeting its other commitments. Borrower agrees that if for any reason it fails
to make any payments required herein, including the amount due at the Maturity
Date, within fifteen (15) days after the due date, Lender shall be entitled to
damages for the detriment caused thereby, the extent of which damages are
extremely difficult and impractical to ascertain. Borrower therefor agrees that
a sum equal to five percent (5%) of such delinquent payment is a reasonable
estimate of such damages and Borrower agrees to pay such sum upon demand by
Lender. Acceptance of such late charge by Lender shall in no event constitute a
waiver of Borrower's default with respect to such overdue amount nor prevent the
Lender from exercising any of the other rights and remedies granted hereunder.
The acceptance by Lender of any payment under this Note after the date that such
payment is due shall not constitute a waiver of the right to require prompt
payment when due of any succeeding payments or to declare a default as herein
provided for any failure to so pay. Acceptance by Lender of the payment of a
portion of any installment at any time that such installment is due and payable
in its entirety shall neither cure nor excuse the default caused by failure to
pay the whole of such installment and shall not constitute a waiver of Lender's
right to require full payment when due of all future or succeeding installments.

           7. Restrictions on Transfer or Encumbrance; Acceleration. The Deed of
Trust provides in part:

           "Neither the Trust Estate nor any part thereof or interest therein
           shall be encumbered, sold (including sale by contract or installment
           sale), conveyed, or otherwise transferred either by Trustor or by
           operation of law, without 




                                      -4-
<PAGE>   5

           Beneficiary's prior written consent, nor without Beneficiary's prior
           written consent shall there be any change in the ownership of any
           stock in a corporate Trustor, in the ownership of any general
           partnership interest in any general or limited partnership Trustor,
           in the ownership of any membership interest in a limited liability
           company or in the ownership of any beneficial interests in any other
           Trustor which is not a natural person or persons. Any such action
           without Beneficiary's prior written consent shall constitute an event
           of default hereunder and shall be deemed to increase the risk to
           Beneficiary, and Beneficiary may, at its option, declare all sums
           secured hereby immediately due and payable notwithstanding any stated
           maturity date therefor or may, in its sole and absolute discretion,
           consent to such change in title, occupancy or ownership."

           8. Collection Expenses. Borrower shall reimburse Lender on demand for
all reasonable and necessary attorneys' fees and other costs and expenses
incurred in collecting or enforcing this Note and protecting or realizing on any
collateral, together with interest at the default rate provided in Section 6.2
above. Without limitation, such fees and costs shall include attorneys' and
other fees, costs and expenses incurred with or without suit and in any appeal,
any proceedings, bankruptcy action, state receivership, and any post-judgment
collection proceedings.

           9. Waivers. Borrower waives diligence, presentment and demand for
payment, notice of dishonor, protest and notice of protest.

           10. Governing Law. This Note shall be construed, enforced and
otherwise governed by the laws of the internal State of California.

           11. Binding Effect. This Note shall bind the successors and assigns
of Borrower and all endorsers hereto and shall inure to the benefit of Lender,
and Lender's successors and assigns. This Note may not be modified except by
written agreement signed by both Lender and Borrower.

           12. Notices. Any notice to Borrower under this Note shall be to
Borrower's address in the Loan Agreement and shall be deemed received as set
forth therein.

           13. Maximum Interest Rate. In no event shall the interest rate on
this Note be higher than the maximum rate permitted by applicable law, if any.
All agreements between Borrower and Lender herein are expressly limited so that
in no event whatsoever, whether by reason of advancement of the proceeds hereof,
acceleration of maturity of the unpaid principal balance hereof, or otherwise,
shall the amount paid or agreed to be paid to Lender for the use, forbearance or
detention of the money to be advanced hereunder exceed the highest lawful rate
permissible under the applicable usury law. If, from any circumstances
whatsoever, fulfillment of any provision hereof or any other agreement relating
to this Note, shall involve


                                      -5-
<PAGE>   6
transcending the limit of validity prescribed by law which a court of competent
jurisdiction may deem applicable thereto, then ipso facto, the obligation to be
fulfilled shall be reduced to the limit of such validity, and if from any
circumstance, Lender shall ever receive as interest an amount in excess of such
maximum interest rate, if any, such amount shall be refunded to Borrower. This
provision shall control every other provision of all agreements between Borrower
and Lender.


           14. Severability. The invalidity of any one or more covenants,
phrases, clauses, sentences or paragraphs of this Note shall not affect the
remaining portions of this Note or any part thereof, and the same shall be
construed as if such invalid covenants, phrases, clauses, sentences or
paragraphs, if any had not been inserted herein.

           15. Time of Essence. Time is of the essence herein.

           16. Authority. Each person signing this document on behalf of
Borrower warrants that such person is duly authorized to sign and deliver this
Note on behalf of Borrower and that this Note is binding on Borrower in
accordance with its terms.

                            BORROWER:

                            SCIENCE PARK CENTER LLC
                            A California Limited Liability Company

                            By Nexus Properties, Inc.
                            A California Corporation
                            Manager


                            By:        /s/ MICHAEL J. REIDY
                                      ----------------------------
                                      Michael J. Reidy
                                      Chief Executive Officer

                            By Neurocrine Biosciences, Inc.
                            A Delaware Corporation
                            Manager


                            By:        /s/ PAUL W. HAWRAN
                                      ----------------------------
                                       Paul W. Hawran
                                       Senior Vice President



                                      -6-

<PAGE>   1
                                                                    EXHIBIT 10.5

                               OPERATING AGREEMENT

                                       FOR

                             SCIENCE PARK CENTER LLC
                     A California Limited Liability Company



* Certain confidential portions of this Exhibit were omitted by means of
  blackout of the text (the "Mark"). This Exhibit has been filed separately with
  the Secretary of the Commission without the Mark pursuant to the Company's
  Application Requesting Confidential Treatment under Rule 24b-2 under the
  Securities Exchange Act.
<PAGE>   2


                                TABLE OF CONTENTS
<TABLE>
<CAPTION>
                                                                                          Page

<S>            <C>                                                                          <C>
ARTICLE I      DEFINITIONS...................................................................3
               1.1    "Act"..................................................................3
               1.2    "Adjusted Capital Account Deficit".....................................3
               1.3    "Affiliate"............................................................3
               1.4    "Agreement"............................................................4
               1.5    "Articles".............................................................4
               1.6    "Bankruptcy"...........................................................4
               1.7    "Book Gain"............................................................4
               1.8    "Book Loss"............................................................4
               1.9    "Book Value"...........................................................4
               1.10   "Building".............................................................4
               1.11   "Built-In Gain (or Loss)"..............................................4
               1.12   "Capital Contribution".................................................5
               1.13   "Code".................................................................5
               1.14   "Company"..............................................................5
               1.15   "Company Minimum Gain".................................................5
               1.16   "Corporations Code"....................................................5
               1.17   "Development Services Agreement".......................................5
               1.18   "Dissolution Event"....................................................5
               1.19   "Distributable Cash"...................................................5
               1.20   "Economic Interest"....................................................5
               1.21   "Economic Interest Owner"..............................................5
               1.22   "Fiscal Year"..........................................................6
               1.23   "Improvements".........................................................6
               1.24   "Land".................................................................6
               1.25   "Managers".............................................................6
               1.26   "Member"...............................................................6
               1.27   "Membership Interest"..................................................6
               1.28   "Member Minimum Gain"..................................................6
               1.29   "Member Nonrecourse Debt"..............................................6
               1.30   "Member Nonrecourse Deductions"........................................6
               1.31   "Net Income" or "Net Loss".............................................6
               1.32   "Neurocrine Construction Loan Agreement"...............................7
               1.33   "Neurocrine Lease".....................................................7
               1.34   "Neurocrine Loan"......................................................7
               1.35   "Nonrecourse Debt".....................................................7
               1.36   "Nonrecourse Deductions"...............................................7
               1.37   "Option Agreement".....................................................7
               1.38   "Percentage Interest"..................................................7
</TABLE>
                                     - i -
<PAGE>   3
<TABLE>
<S>            <C>                                                                          <C>
               1.39   "Permanent Loan".......................................................8
               1.40   "Person"...............................................................8
               1.41   "Preferred Return".....................................................8
               1.42   "Preferred Capital Return".............................................8
               1.43   "Premises".............................................................8
               1.44   "Prime Rate"...........................................................8
               1.45   "Property".............................................................8
               1.46   "Regulations"..........................................................8
               1.47   "Regulatory Allocations"...............................................8
               1.48   "Rent".................................................................8
               1.49   "Schedules"............................................................8
               1.50   "Substituted Member"...................................................9
               1.51   "Tax Matters Partner"..................................................9
               1.52   "Tokai Construction Loan"..............................................9
               1.53   "Unreturned Capital Contribution"......................................9

ARTICLE II     ORGANIZATIONAL MATTERS........................................................9
               2.1    Formation..............................................................9
               2.2    Name...................................................................9
               2.3    Term...................................................................9
               2.4    Office and Agent......................................................10
               2.5    Purpose of Company....................................................10

ARTICLE III    CAPITAL CONTRIBUTIONS........................................................10
               3.1    "Capital Account".....................................................10
               3.2    Initial Capital Contribution..........................................12
               3.3    Additional Capital Contributions......................................12
               3.4    Member Loans..........................................................12
               3.5    Neurocrine Loan.......................................................12
               3.6    No Interest...........................................................13
               3.7    Completion and Loan Guarantees........................................13

ARTICLE IV     MEMBERS .....................................................................13
               4.1    Limited Liability.....................................................13
               4.2    Admission of Additional Members.......................................13
               4.3    Withdrawal, Resignation or Retirement.................................13
               4.4    Transactions With the Company.........................................14
               4.5    Remuneration To Members...............................................14
               4.6    Members Are Not Agents................................................14
               4.7    Voting Rights.........................................................14
               4.8    Meetings of Members...................................................14
                      4.8.1   Date, Time and Place of Meetings of Members; Secretary........14
                      4.8.2   Power to Call Meetings........................................14
</TABLE>
                                     - ii -
<PAGE>   4
<TABLE>
<S>            <C>                                                                          <C>
                      4.8.3   Notice of Meeting.............................................14
                      4.8.4   Manner of Giving Notice.......................................15
                      4.8.5   Validity of Action............................................15
                      4.8.6   Quorum........................................................15
                      4.8.7   Adjourned Meeting; Notice.....................................15
                      4.8.8   Waiver of Notice or Consent...................................15
                      4.8.9   Action by Written Consent without a Meeting...................16
                      4.8.10  Telephonic Participation by Member at Meetings................16
                      4.8.11  Record Date...................................................16
                      4.8.12  Proxies.......................................................17

ARTICLE V      MANAGEMENT AND CONTROL OF THE COMPANY........................................17
               5.1    Management of the Company by Managers.................................17
                      5.1.1    Management by Managers.......................................17
                      5.1.2    Agency Authority of Managers.................................17
               5.2    Election of Managers..................................................18
                      5.2.1   Number, Term and Qualifications...............................18
                      5.2.2   Resignation...................................................18
                      5.2.3   Removal.......................................................18
                      5.2.4   Vacancies.....................................................19
               5.3    Powers of Managers....................................................19
                      5.3.1   Powers of Managers............................................19
                      5.3.2   Limitations on Power of Managers..............................19
               5.4    Obligations of the Managers...........................................21
               5.5    Members Have No Managerial Authority..................................22
               5.6    Performance of Duties; Liability of Managers..........................22
               5.7    Devotion of Time......................................................22
               5.8    Competing Activities..................................................22
               5.9    Transactions between the Company and the Managers.....................23
               5.10   Acts of Managers as Conclusive Evidence of Authority..................23
               5.11   Limited Liability.....................................................23
               5.12   Resolution of Disputes................................................23

ARTICLE VI     ALLOCATIONS OF NET INCOME AND NET LOSS.......................................23
               6.1    Allocation of Net Income and Net Loss from Operations.................23
               6.2    Allocation of Net Income and Net Loss from Sale or Exchange...........24
                      6.2.1  Net Income Allocations.........................................24
                      6.2.2  Net Loss Allocations...........................................24
               6.3    Special Allocations...................................................24
                      6.3.1  Qualified Income Offset........................................24
                      6.3.2  Gross Income Allocation........................................25
                      6.3.3  Company Minimum Gain Chargeback................................25
                      6.3.4  Member Minimum Gain Chargeback.................................25
</TABLE>
                                    - iii -
<PAGE>   5
<TABLE>
<S>            <C>                                                                          <C>
                      6.3.5  Nonrecourse Deductions.........................................25
                      6.3.6  Member Nonrecourse Deductions..................................25
                      6.3.7  Code Section 754 Adjustments...................................26
                      6.3.8  Curative Allocations...........................................26
               6.4    Contributed Property..................................................26

ARTICLE VII           DISTRIBUTIONS.........................................................26
               7.1    Distribution of Distributable Cash from Sale
                      or Exchange of the Premises...........................................26
               7.2    Distribution of Distributable Cash from
                      Operations Under the Neurocrine Lease.................................27
               7.3    Persons to Receive Distributions......................................28
               7.4    Form of Distribution..................................................28
               7.5    Restriction on Distributions..........................................28
                      7.5.1  Insufficient Assets............................................28
                      7.5.2  Basis of Determination.........................................28
               7.6    Return of Distributions...............................................28
               7.7    Obligations of Members to Report Allocations..........................28

ARTICLE VIII          COMPENSATION TO THE MANGERS, MEMBERS AND AFFILIATES...................29
               8.1    Compensation of Members...............................................29
               8.2    Company Expenses......................................................29
                      8.2.1  Operating Expenses.............................................29
                      8.2.2  Overhead of Managers...........................................29
               8.3    Payments to Nexus.....................................................29

ARTICLE IX     TRANSFER AND ASSIGNMENT OF INTERESTS.........................................29
               9.1    Transfer and Assignment of Interests..................................29
               9.2    Further Restrictions on Transfer of Interests.........................30
               9.3    Substitution of Members...............................................30
               9.4    No Effect to Transfers in Violation of Agreement......................30
               9.5    Transfer of Nexus' Interest to Neurocrine.............................31

ARTICLE X             CONSEQUENCES OF DEATH, DISSOLUTION, RETIREMENT OR
                      BANKRUPTCY OF MEMBER..................................................31
               10.1   Dissolution Event.....................................................31
               10.2   No Effect if Violation of Agreement...................................31

ARTICLE XI     ACCOUNTING, RECORDS, REPORTING BY MEMBERS....................................32
               11.1   Books and Records.....................................................32
               11.2   Delivery to Members and Inspection....................................32
                      11.2.1  Requests for Information......................................32
</TABLE>
                                     - iv -
<PAGE>   6
<TABLE>
<S>            <C>                                                                          <C>
                      11.2.2  Inspection of Records.........................................33
                      11.2.3  Inspection by Representative..................................33
               11.3   Financial Statements/Tax Returns......................................33
                      11.3.1  Annual Statements.............................................33
                      11.3.2  Tax Returns...................................................33
                      11.3.3  Annual Statutory Report.......................................33
               11.4   Filings  .............................................................33
               11.5   Bank Accounts.........................................................33
               11.6   Accounting Decisions and Reliance on Others...........................33
               11.7   Tax Matters for the Company Handled by Members and 
                         Tax Matters Partner................................................34

ARTICLE XII           DISSOLUTION AND WINDING UP............................................34
               12.1   Dissolution...........................................................34
               12.2   Certificate of Dissolution............................................34
               12.3   Winding Up............................................................34
               12.4   Distributions in Kind.................................................35
               12.5   Order of Payment of Liabilities Upon Dissolution......................35
                      12.5.1  Distribution to Members.......................................35
                      12.5.2  Provision for Liabilities.....................................35
               12.6   Compliance with Regulations...........................................36
               12.7   Limitations on Payments Made in Dissolution...........................36
               12.8   Certificate of Cancellation...........................................36
               12.9   No Action for Dissolution.............................................36

ARTICLE XIII          INDEMNIFICATION AND INSURANCE.........................................37
               13.1   Indemnification of Agents.............................................37
               13.2   Insurance.............................................................37


ARTICLE XIV           INVESTMENT REPRESENTATIONS............................................37
               14.1   Preexisting Relationship or Experience................................37
               14.2   No Advertising........................................................37
               14.3   Investment Intent.....................................................38
               14.4   Purpose of Entity.....................................................38
               14.5   Residency.............................................................38
               14.6   Economic Risk.........................................................38
               14.7   No Registration of Membership Interest................................38
               14.8   Membership Interest in Restricted Security............................38
               14.9   No Obligation to Register.............................................38
               14.10  No Disposition in Violation of Law....................................39
               14.11  Legends...............................................................39
               14.12  Investment Risk.......................................................39
               14.13  Restrictions on Transferability.......................................39
</TABLE>

                                     - v -
<PAGE>   7
<TABLE>
<S>            <C>                                                                          <C>
               14.14  Information Reviewed..................................................39
               14.15  No Representations By Company.........................................40
               14.16  Consultation with Attorney............................................40
               14.17  Tax Consequences......................................................40
               14.18  No Assurance of Tax Benefits..........................................40
               14.19  Indemnity.............................................................40
               14.20  Representations by Nexus..............................................41
                      14.20.1       Status..................................................41
                      14.20.2       Due Authorization.......................................41
                      14.20.3       Other Agreements........................................41
               14.21  Representations of Neurocrine.........................................41
                      14.21.1       Status..................................................42
                      14.21.2       Due Authorization.......................................42
                      14.21.3       Other Agreements........................................42

ARTICLE XV            MISCELLANEOUS.........................................................42
               15.1   Representation by Counsel.............................................42
               15.2   Binding Effect........................................................42
               15.3   Parties in Interest...................................................43
               15.4   Pronouns: Statutory References........................................43
               15.5   Headings..............................................................43
               15.6   Interpretation........................................................43
               15.7   References to this Agreement..........................................43
               15.8   Governing Law/Jurisdiction/Venue......................................43
               15.9   Arbitration...........................................................43
               15.10  Severability..........................................................43
               15.11  Additional Documents and Acts.........................................44
               15.12  Notices...............................................................44
               15.13  Amendments............................................................44
               15.14  Reliance on Authority of Person Signing Agreement.....................44
               15.15  No Interest in Company Property: Waiver of Action for Partition.......44
               15.16  Multiple Counterparts.................................................44
               15.17  Attorney Fees.........................................................44
               15.18  Time is of the Essence................................................45
               15.19  Remedies Cumulative...................................................45
               15.20  Neurocrine Default....................................................45
</TABLE>

                                     - vi -


<PAGE>   8
                               OPERATING AGREEMENT

                                       FOR

                             SCIENCE PARK CENTER LLC
                     A CALIFORNIA LIMITED LIABILITY COMPANY


        This Operating Agreement for SCIENCE PARK CENTER LLC, a California
limited liability company (the "Company"), is made effective July 31, 1997, by
and among NEUROCRINE BIOSCIENCES, INC., a Delaware corporation ("Neurocrine"),
and NEXUS PROPERTIES, INC., a California corporation ("Nexus"), with reference
to the following facts:

                                           RECITALS

        A. Neurocrine and Nexus have formed the Company as a limited liability
company under the laws of the State of California. On April 2, 1997, Articles of
Organization for the Company were filed with the California Secretary of State
(File No. 101997092011), and on April 21, 1997, an amendment to the Articles of
Organization were filed with the Secretary of State.

        B. Neurocrine, Nexus and Brandon Crocker ("Crocker") are the only
Members of the Company, and Nexus and Neurocrine are the only Managers of the
Company.

        C. The Company intends to purchase from Neurocrine certain real property
legally described as Lot 30 of Torrey Pines Science Center Unit No. 2, in the
City of San Diego, County of San Diego, State of California, according to Map
thereof No. 12845, filed in the Office of the County Recorder of San Diego
County, July 23, 1991 (the "Land") for a purchase price of $3,472,000. The
purchase price shall be financed in its entirety by a loan from Neurocrine to
the Company. In addition, the Company intends to borrow $368,000 from Neurocrine
for the construction of improvements on the Land pursuant to that certain
Construction Loan Agreement of even date between the Company and Neurocrine
("Neurocrine Construction Loan Agreement"). The two Neurocrine loans
(collectively, the "Neurocrine Loan") will be represented by a promissory note
payable by the Company to Neurocrine in the aggregate principal sum of
$3,840,000, bearing interest at the rate of 8.25%, which note will be secured by
a deed of trust on the Land and improvements.

                                      -1-
<PAGE>   9

        D. The Company intends (i) to develop and construct a research and
administrative building on the Land to consist of two levels over a single level
of subterranean area (the "Building"); and (ii) to develop and construct
landscaping, drainage, irrigation, lighting, parking facilities, walkways,
driveways and other improvements and appurtenances related thereto (the
"Improvements"). The Land, Building and Improvements are sometimes collectively
referred to herein as the "Premises".

        E. The Company is leasing the Premises to Neurocrine pursuant to that
certain lease of even date between the parties (the "Neurocrine Lease").
Pursuant to the Neurocrine Lease, the Company will construct the Building and
Improvements with a construction loan (the "Tokai Construction Loan") from Tokai
Bank of California ("Tokai Bank") in the approximate amount of *** secured by a
first deed of trust on the Premises, the $368,000 borrowed from Neurocrine as
part of the Neurocrine Loan secured by a second deed of trust on the Premises,
and a capital contribution to the Company by Nexus in the amount of ***.
Following completion of construction, the Company contemplates obtaining a
permanent loan (the "Permanent Loan") to replace the Tokai Construction Loan,
which will be senior to the Neurocrine Loan. Rent under the Neurocrine Lease
("Rent") will be adjusted after completion of construction to an amount equal to
*** of the total costs for the acquisition, development and construction of the
Premises, increased each year by ***, all as set forth in the Neurocrine Lease.
***.

        F. Neurocrine also has an Option to Purchase the Premises from the
Company which is set forth in that certain Option Agreement between the Company
and Neurocrine (the "Option Agreement"). Under the Option Agreement, the
purchase price for the Premises is ***.

        G. Attached hereto are three (3) schedules (the "Schedules") which show
the initial projections of the parties with respect to the above matters.
Schedule 1 is a project budget; Schedule 2 is an estimated cash distribution
schedule; and Schedule 3 is the estimated option

* confidential treatment
                                      -2-

<PAGE>   10
purchase price. Although the parties acknowledge that the figures in the
Schedules will be different based on ultimate construction costs, interest
rates, and Rent amount, the Schedules are attached hereto in order to reflect
the intent of the parties in entering into this Agreement.

       H. The parties hereto desire to adopt and approve an operating agreement
for the Company.

        NOW, THEREFORE, Neurocrine, Nexus and Crocker (hereinafter sometimes
collectively referred to as "Members," and individually as "Member") by this
Agreement set forth the operating agreement for the Company under the laws of
the State of California upon the terms and subject to the conditions of this
Agreement.

                                    ARTICLE I
                                   DEFINITIONS

        When used in this Agreement, the following terms shall have the meanings
set forth below:

        1.1 "ACT" shall mean the Beverly-Killea Limited Liability Company Act,
California Corporations Code Section 17000 et seq., as the same may be amended
from time to time.

        1.2 "ADJUSTED CAPITAL ACCOUNT DEFICIT" shall mean, with respect to any
Member, the deficit balance, if any, in such Member's Capital Account as of the
end of the relevant fiscal year, after giving effect to the following
adjustments:

                (i) Credit to such Capital Account any amounts which the Member
is obligated to restore and the Member's share of Member Minimum Gain and
Company Minimum Gain; and

               (ii) Debit to such Capital Account the items described in
Treasury Regulations Sections 1.704-1(b)(2)(ii)(d)(4), 1.704-1(b)(2)(ii)(d)(5),
and 1.704-1(b)(2)(ii)(d)(6).

        1.3 "AFFILIATE" shall mean any individual, partnership, corporation,
trust or other entity or association, directly or indirectly, through one or
more intermediaries, controlling, controlled by, or under common control with
the Member. The term "control," as used in the immediately preceding sentence,
means, with respect to a corporation or limited liability company the right to
exercise, directly or indirectly, more than 10% of the voting rights
attributable to the controlled corporation or limited liability company, and,
with respect to any individual, partnership, trust, other entity or association,
the possession, directly or indirectly, of the power to direct or cause the
direction of the management or policies of the controlled entity.


                                      -3-
<PAGE>   11

        1.4 "AGREEMENT" shall mean this Operating Agreement, as originally
executed and as amended from time to time.

        1.5 "ARTICLES" shall mean the Articles of Organization for the Company
originally filed with the California Secretary of State and as amended from time
to time.

        1.6 "BANKRUPTCY" shall mean: (a) the filing of an application by a
Member for, or a Member's consent to, the appointment of a trustee, receiver, or
custodian of the Member's other assets; (b) the entry of an order for relief
with respect to a Member in proceedings under the United States Bankruptcy Code,
as amended or superseded from time to time; (c) the making by a Member of a
general assignment for the benefit of creditors; (d) the entry of an order,
judgment, or decree by any court of competent jurisdiction appointing a trustee,
receiver, or custodian of the assets of a Member unless the proceedings and the
person appointed are dismissed within 90 days; or (e) the failure by a Member
generally to pay the Member's debts as the debts become due within the meaning
of Section 303(h)(1) of the United States Bankruptcy Code, as determined by the
Bankruptcy Court, or the admission in writing by a Member of such Member's
inability to pay the Member's debts as they become due.

        1.7 "BOOK GAIN" shall mean the excess, if any, of the fair market value
of the Property over its adjusted basis for federal income tax purposes at the
time a valuation of the Property is required under this Agreement or Treasury
Regulations Section 1.704-1(b) for purposes of making adjustments to the Capital
Accounts.

        1.8 "BOOK LOSS" shall mean the excess, if any, of the adjusted basis of
the Property for federal income tax purposes over its fair market value at the
time a valuation of the Property is required under this Agreement or Treasury
Regulations Section 1.704-1(b) for purposes of making adjustments to the Capital
Accounts.

        1.9 "BOOK VALUE" shall mean the adjusted basis of Property for federal
income tax purposes increased or decreased by Book Gain, Book Loss, Built-In
Gain and Built-In Loss as reduced by depreciation, amortization or other cost
recovery deductions, or otherwise, based on such Book Value.

        1.10 "BUILDING" shall have the meaning given the term in Recital D of
this Agreement.

        1.11 "BUILT-IN GAIN (OR LOSS)" shall mean the amount, if any, by which
the agreed value of contributed Property exceeds (or is lesser than) the
adjusted basis of Property contributed to the Company by a Member immediately
after its contribution by the Member to the capital of the Company.

                                      -4-
<PAGE>   12
        1.12 "CAPITAL CONTRIBUTION" shall mean the total value of cash and fair
market value of property, including promissory notes or other obligation to
contribute cash or property, contributed to the Company by Members.

        1.13 "CODE" shall mean the Internal Revenue Code of 1986, as amended
from time to time, the provisions of succeeding law, and to the extent
applicable, the Regulations.

        1.14   "COMPANY" shall mean Science Park Center LLC.

        1.15 "COMPANY MINIMUM GAIN" shall meaning "partnership minimum gain" as
set forth in Treasury Regulations Sections 1.704-2(d).

        1.16 "CORPORATIONS CODE" shall mean the California Corporations Code, as
amended from time to time, and the provisions of succeeding law.

        1.17   "DEVELOPMENT SERVICES FEE" shall have the meaning given the term
in Section 8.3 hereof.

        1.18   "DISSOLUTION EVENT" shall mean with respect to any Member one or
more of the following: the death, insanity, withdrawal, resignation, retirement,
expulsion, Bankruptcy, dissolution or occurrence of any other event which
terminates the continued membership of the Member unless other Members holding
at least two-thirds of the other Membership Interests consent to continue the
business of the Company pursuant to Section 12.1.

        1.19 "DISTRIBUTABLE CASH" shall mean the amount of cash which the
Managers deem available for distribution to the Members pursuant to Article VII,
taking into account all Company debts, liabilities, and obligations of the
Company then due and amounts which the Managers deem necessary to place into
reserves for customary and usual claims with respect to the Company's business.
Notwithstanding the foregoing, no cash shall be deemed Distributable Cash unless
payments on all notes secured by deeds of trust encumbering the Premises are
current; provided, however, that distributions to Nexus pursuant to Section 7.2
shall be made before payments are made on the Neurocrine Loan.

        1.20 "ECONOMIC INTEREST" shall mean a Member's or Economic Interest
Owner's share of one or more of the Company's Net Income, Net Loss, and
distributions of the Company's assets pursuant to this Agreement and the Act,
but shall not include any other rights of a Member, including, without
limitation, the right to vote or participate in the management, or, except as
provided in Section 17106 of the Corporations Code, any right to information
concerning the business and affairs of Company.

        1.21 "ECONOMIC INTEREST OWNER" shall mean the owner of an Economic
Interest who is not a Member. Crocker shall automatically become an Economic
Interest Owner, and

                                      -5-
<PAGE>   13
shall no longer be a Member, upon the retirement of the Tokai Construction Loan,
without any further act or consent required of Crocker, the Managers, or the
Members.

        1.22 "FISCAL YEAR" shall mean the Company's fiscal year, which shall be
the calendar year.

        1.23 "IMPROVEMENTS" shall have the meaning given the term in Recital D
of this Agreement.

        1.24 "LAND" shall have the meaning given the term in Recital C of this
Agreement.

        1.25 "MANAGERS" shall mean Nexus and Neurocrine, and the singular
"Manager" shall mean either of them or any other Person that succeeds either of
them in that capacity. If at any time only one manager is appointed, the plural
"Managers" shall include the singular "Manager."

        1.26 "MEMBER" shall mean Neurocrine, Nexus and Crocker, and each other
Person who is later admitted to the Company as a Member in accordance with this
Agreement, or is an assignee who has become a Member in accordance with Article
IX, so long as Neurocrine, Nexus, Crocker, or any such Person has not resigned,
withdrawn, retired, been expelled or, if other than an individual, dissolved.
Crocker shall automatically become an Economic Interest Owner, and shall no
longer be a Member, upon the retirement of the Tokai Construction Loan, without
any further act or consent required of Crocker, the Managers, or the Members.

        1.27 "MEMBERSHIP INTEREST" shall mean a Member's entire interest in the
Company, including the Member's Economic Interest, the right to vote on or
participate in the management of the Company, and the right to receive
information concerning the business and affairs of the Company.

        1.28 "MEMBER MINIMUM GAIN" shall mean "partner nonrecourse debt minimum
gain" as determined under Treasury Regulations Section 1.704-2(i)(3).

        1.29 "MEMBER NONRECOURSE DEBT" shall mean "partner nonrecourse debt" as
set forth in Treasury Regulations Section 1.704-2(b)(4).

        1.30 "MEMBER NONRECOURSE DEDUCTIONS" shall mean of "partner nonrecourse
deductions," and the amount thereof shall be, as set forth in Treasury
Regulations Section 1.704-2(i).

        1.31 "NET INCOME" or "NET LOSS" shall mean, respectively, for each
taxable year of the Company the taxable income and taxable loss (exclusive of
Built-In Gain or Loss) of the Company as determined for federal income tax
purposes in accordance with Section 703(a) of the Code (including all items of
income, gain, loss, or deduction required to be separately 


                                      -6-
<PAGE>   14
stated pursuant to Section 703(a)(1) of the Code) (other than any specific item
of income, gain (exclusive of Built-In Gain), loss (exclusive of Built-In Loss),
deduction or credit subject to special allocation under this Agreement), with
the following modifications:

                (i) The amount determined above shall be increased by any income
exempt from federal income tax;

                (ii) The amount determined above shall be reduced by any
expenditures described in Section 705(a)(2)(B) of the Code or expenditures
treated as such pursuant to Treasury Regulations Section 1.704-1(b)(2)(iv)(i);

                (iii) Depreciation, amortization and other cost recovery
deductions shall be computed based on Book Value instead of on the amount
determined in computing taxable income or loss. Any item of deduction,
amortization or cost recovery specially allocated to a Member and not included
in Net Income or Net Loss shall be determined for Capital Account purposes in a
similar manner; and

                (iv) For purposes of this Agreement, Book Gain and Book Loss
attributable to a revaluation of Property attributable to unrealized gain or
loss in such Property shall be treated as Net Income and Net Loss.

        1.32 "NEUROCRINE CONSTRUCTION LOAN AGREEMENT" shall have the meaning
given the term in Recital C of this Agreement.

        1.33 "NEUROCRINE LEASE" shall have the meaning given the term in Recital
E of this Agreement.

        1.34 "NEUROCRINE LOAN" shall have the meaning given the term in Recital
C of this Agreement.

        1.35 "NONRECOURSE DEBT" shall have the meaning set forth in Treasury
Regulations Section 1.704-2(b)(3).

        1.36 "NONRECOURSE DEDUCTIONS" shall have the meaning, and the amount
thereof shall be, as set forth in Treasury Regulations Section 1.704-2(c).

        1.37 "OPTION AGREEMENT" shall have the meaning given the term in Recital
F of this Agreement.

        1.38 "PERCENTAGE INTEREST" shall mean the following percentages of the
Members, which percentages shall not be adjusted as relative proportions of the
Capital Accounts of the Members are adjusted from time to time, but shall be
adjusted with the consent of Members

                                      -7-
<PAGE>   15
holding at least two-thirds of the Membership Interests: Nexus ***; Neurocrine
***; and Crocker ***.

        1.39 "PERMANENT LOAN" shall have the meaning given the term in Recital E
of this Agreement.

        1.40 "PERSON" shall mean an individual, general partnership, limited
partnership, limited liability company, corporation, trust, estate, real estate
investment trust, association or any other entity.

        1.41 "PREFERRED RETURN" shall mean a *** compounded annually in arrears
on *** beginning on the Term Commencement Date of the Neurocrine Lease;
provided, however, that the *** amount shall be reduced by and at the time of
any distribution made pursuant to Section 7.1(iv), or by and at the time Nexus
receives such amount from other sources.

        1.42 "PREFERRED CAPITAL RETURN" shall mean a percentage per annum return
*** on Nexus' Unreturned Capital Contribution equal to what Tokai Bank would
charge for an unsecured loan of ***.

        1.43 "PREMISES" shall have the meaning given the term in Recital D of
this Agreement and the Neurocrine Lease.

        1.44 "PRIME RATE" shall mean the reference rate announced from
time-to-time by the bank at which the Company's bank accounts are maintained,
and changes in the Prime Rate shall be deemed to occur on the date that changes
in such rate are announced.


        1.45 "PROPERTY" shall refer to any and all of such real and tangible or
intangible personal property or properties as may be acquired by the Company,
including the Premises.

        1.46 "REGULATIONS" shall mean, unless the context clearly indicates
otherwise, the regulations currently in force as final or temporary that have
been issued by the U.S. Department of Treasury pursuant to its authority under
the Code.

        1.47 "REGULATORY ALLOCATIONS" shall mean the allocations set forth in
Sections 6.3.1 through 6.3.7.

        1.48 "RENT" shall have the meaning given the term in the Neurocrine
Lease and Recital E of this Agreement.

        1.49 "SCHEDULES" shall mean the schedules described in Recital G and
attached to this Agreement.

* confidential treatment
                                      -8-
<PAGE>   16
        1.50 "SUBSTITUTED MEMBER" shall mean any person admitted as a
Substituted Member pursuant to this Agreement.

        1.51 "TAX MATTERS PARTNER" shall be Neurocrine or its successor as
designated pursuant to Section 11.7.

        1.52 "TOKAI CONSTRUCTION LOAN" shall have the meaning given the term in
Recital E of this Agreement.

        1.53 "UNRETURNED CAPITAL CONTRIBUTION" shall mean the *** initial
Capital Contribution of Nexus, reduced by all distributions to Nexus under
Sections 7.1(ii) and 7.2(ii) of this Agreement.

                                   ARTICLE II
                             ORGANIZATIONAL MATTERS

        2.1 FORMATION. The Members have formed a California limited liability
company under the Act and other applicable laws of the State of California by
filing the Articles with the California Secretary of State on April 2, 1997 and
entering into this Agreement. The rights and liabilities of the Members shall be
determined pursuant to the Act and this Agreement. To the extent that the rights
or obligations of any Member are different by reason of any provision of this
Agreement than they would be in the absence of such provision, this Agreement
shall, to the extent permitted by the Act, control.

        2.2 NAME. The name of the Company shall be Science Park Center LLC. The
business of the Company may be conducted under that name or, upon compliance
with applicable laws, any other name that the Managers deem appropriate or
advisable. The Managers shall file any fictitious name certificates and similar
filings, and any amendments thereto, that the Managers consider appropriate or
advisable.

        2.3 TERM. The term of this Agreement shall expire on December 31, 2022,
unless extended or sooner terminated as hereinafter provided. However, in the
event the Company is unable on or before October 1, 1997 to secure (i) the Tokai
Construction Loan or another construction loan in an amount and on terms
satisfactory to Neurocrine, or (ii) grading, foundation or other permits
necessary for the commencement of construction of the Building and Improvements,
the Company shall, at the election of Neurocrine, immediately be dissolved and
terminated. Notwithstanding the provisions of Sections 7.1, 7.2 and 12.5.1 of
this Agreement to the contrary, if the Company is dissolved and terminated
pursuant to the immediately preceding sentence, or if the Neurocrine Lease is
terminated pursuant to Section 4.2 thereof, then (i) the Property shall be
distributed in kind to Neurocrine subject to any deeds of trust encumbering the
Property, (ii) Nexus shall be paid an amount equal to its initial Capital
Contribution of *** (if and to the extent made), plus an amount equal to
its

* confidential treatment

                                      -9-
<PAGE>   17
Preferred Capital Return, from Distributable Cash, (iii) if the amount of
Distributable Cash is insufficient to pay the amount due to Nexus pursuant to
clause (ii) above, Neurocrine shall pay the deficiency, (iv) if the amount of
Distributable Cash exceeds the amount payable to Nexus pursuant to clause (ii)
above, Neurocrine shall be entitled to such excess, and (v) the provisions of
Section 12.4 hereof will not apply. In the event of such dissolution, Nexus
shall not be entitled to (i) any amounts that otherwise would be due to it
pursuant to Sections 5.9 and 8.3 of this Agreement, (ii) the Preferred Return,
or (iii) the *** described in subsection 7.1(iv).

        2.4 OFFICE AND AGENT. The Company shall continuously maintain an office
and registered agent in the State of California as required by the Act. The
initial principal office of the Company shall be 3250 La Jolla Village Drive,
Suite 930, San Diego, California 92122, and shall otherwise be as the Managers
may determine. The registered agent shall be as stated in the Articles or as
otherwise determined by the Managers.

        2.5 PURPOSE OF COMPANY. The purpose of the Company is to engage in any
lawful activity for which a limited liability company may be organized under the
Act. Notwithstanding the foregoing, without the unanimous consent of the
Managers, the Company shall not engage in any business other than the business
of developing, financing, improving, leasing, and selling the Premises, and such
other activities directly related to the foregoing business as may be necessary,
advisable, or appropriate to further the foregoing business.

                                   ARTICLE III
                              CAPITAL CONTRIBUTIONS

        3.1 "CAPITAL ACCOUNT" with respect to any Member (or such Member's
assignee) shall mean such Member's initial Capital Contribution adjusted as
follows:

               3.1.1 A Member's Capital Account shall be increased by:

                       (i)    Such Member's share of Net Income;

                       (ii) Any income or gain specially allocated to a Member
and not included in Net Income or Net Loss;

                       (iii) Any additional cash Capital Contribution made by
such Member to the Company; and

                        (iv) The fair market value of any additional Capital
Contribution consisting of property contributed by such Member to the capital of
the Company reduced by any liabilities assumed by the Company in connection with
such contribution or to which the property is subject.

* confidential treatment

                                      -10-
<PAGE>   18
               3.1.2   A Member's Capital Account shall be reduced by:

                       (i)    Such Member's share of Net Loss;

                       (ii) Any deduction specially allocated to a Member and
not included in Net Income or Net Loss;

                       (iii) Any cash distribution to such Member; and

                       (iv) The fair market value, as agreed to by Members
holding at least two-thirds of the Membership Interests, of any Property
(reduced by any liabilities assumed by the Member in connection with the
distribution or to which the distributed Property is subject) distributed to
such Member; provided that, upon liquidation and winding up of the Company,
unsold Property will be valued for distribution at its fair market value and the
Capital Account of each Member before such distribution shall be adjusted to
reflect the allocation of gain or loss that would have been realized had the
Company then sold the Property for its fair market value. Such fair market value
shall not be less than the amount of any nonrecourse indebtedness that is
secured by the Property.

        Property other than money may not be contributed to the Company except
as specifically provided in this Agreement. Property of the Company may not be
revalued for purposes of calculating Capital Accounts unless all of the
following occur:

                (i) The Members, pursuant to the consent of Members holding at
least two-thirds of the Membership Interests, agree on the fair market value of
the Property; provided, however for purposes of calculating Book Gain or Book
Loss (but not for purposes of adjusting Capital Accounts to reflect the
contribution and distribution of such Property), the fair market value of
Property shall be deemed to be no less than the outstanding balance of any
nonrecourse indebtedness secured by such Property;

                (ii) Capital Accounts are adjusted to reflect the contribution
or revaluation (including, without limitation, the valuation of such Property
and the selection of book depreciation methods); and

                (iii) The Members, pursuant to the consent of Members holding at
least two-thirds of the Membership Interests, agree on the allocation among the
Members of items of income, gain, depreciation, amortization and loss relating
to such Property for federal income tax purposes.

               The Capital Account of a Substituted Member or an Economic
Interest Owner shall include the Capital Account of his transferor.
Notwithstanding anything to the contrary in this Agreement, Capital Accounts
shall be maintained in accordance with Treasury Regulations Section 1.704-1(b),
and allocations of items of income and loss of the Company 

                                      -11-
<PAGE>   19
shall be adjusted as necessary consistent with the foregoing to cause the
Capital Accounts of the members to be sufficient to permit the distributions
required under Sections 2.3, 7.1, 7.2 and 12.5. References in this Agreement to
the Treasury Regulations shall include corresponding subsequent provisions.

        3.2 INITIAL CAPITAL CONTRIBUTION. Nexus shall contribute an initial
Capital Contribution consisting of cash in the amount of *** concurrently
with the initial funding of the Tokai Construction Loan; Neurocrine shall not be
required to make an initial Capital Contribution.

        3.3 ADDITIONAL CAPITAL CONTRIBUTIONS. Additional Capital Contributions
may be made by Neurocrine; provided, however, that Neurocrine shall have no
obligation to make any additional Capital Contributions. Neurocrine may make
Capital Contributions for any reason, including, but not limited to, any
remaining distribution to Nexus required pursuant to Section 7.1 or 7.2 or to
repay any indebtedness of the Company.

        3.4 MEMBER LOANS. Neurocrine or an Affiliate may make a loan to the
Company to the extent required to pay the Company's operating expenses,
including debt service. Except for the Neurocrine Loan, any such loan shall bear
interest at the Prime Rate plus 2% and provide for the payment of principal and
any accrued but unpaid interest in accordance with the terms of the promissory
note evidencing such loan approved by Neurocrine, but in no event later than
upon dissolution of the Company. Except with the consent of Members holding at
least two-thirds of the Membership Interests, or as may be expressly provided in
this Agreement, no Member or any Affiliate may make any loan to the Company.
Except for the Neurocrine Loan, amounts due on loans made pursuant to this
Section shall be repaid from Distributable Cash or proceeds from the sale or
exchange of the Premises before any further distributions are made pursuant to
Sections 7.1 or 7.2. A Member shall have the right to exercise remedies with
respect to any loans made by such Member to the Company (including, without
limitation, the Neurocrine Loan) without being in violation of any duty it may
have by reason of its status as a Member of the Company.

        3.5 NEUROCRINE LOAN. Pursuant to a Purchase and Sale Agreement between
the Company and Neurocrine, Neurocrine will sell the Land to the Company for a
purchase price of $3,472,000. The purchase price shall be financed in its
entirety by a loan from Neurocrine to the Company. In addition, pursuant to the
Neurocrine Construction Loan Agreement, Neurocrine will loan to the Company
$368,000, or such greater or lesser amount as may be required to pay all costs
of construction of the Building and Improvements in excess of the ***
Tokai Bank loan and the *** Capital Contribution of Nexus. The purchase
price and the loan (defined above as the "Neurocrine Loan") will be represented
by a promissory note payable by the Company to Neurocrine in the aggregate
principal sum of $3,840,000 (or such greater or lesser amount as may have been
advanced by Neurocrine to the Company pursuant to this Section 3.5), which note
will be secured by a deed of trust on the Premises. The Neurocrine Loan will
bear interest at 8.25% per annum with interest and 

* confidential treatment

                                      -12-
<PAGE>   20
principal amortized over a ten-year period commencing on the Term Commencement
Date as defined in the Neurocrine Lease.

        3.6 NO INTEREST. No Member shall be entitled to receive any interest on
the Member's Capital Contributions except as set forth herein.

        3.7 COMPLETION AND LOAN GUARANTEES. To the extent required by Tokai Bank
(or such other construction lender approved by the Managers), Neurocrine will
execute a guarantee of the completion of the Building and Improvements in a form
reasonably acceptable to the lender and Neurocrine, and Nexus will provide any
personal guarantees which the lender may require. A Member's guaranty of an
obligation shall not result in the adjustment of such Member's Capital Account.

                                   ARTICLE IV
                                     MEMBERS

        4.1 LIMITED LIABILITY. Except as required under the Act or as expressly
set forth in this Agreement, no Member shall be personally liable for any debt,
obligation, or liability of the Company, whether that liability or obligation
arises in contract, tort, or otherwise.

        4.2 ADMISSION OF ADDITIONAL MEMBERS. Additional Members may be admitted
to the Company only with the consent of Members holding at least two-thirds of
the Membership Interests. Any additional Members shall obtain Membership
Interests and will participate in the management, Net Income, Net Loss, and
distributions of the Company on such terms as are determined by the consent of
Members holding at least two-thirds of the Membership Interests. Notwithstanding
the foregoing, Substituted Members may only be admitted in accordance with
Article IX. Additionally, notwithstanding the foregoing, at any time after the
Tokai Construction Loan is retired, Nexus and Crocker may assign their
Membership Interests (but not the duties of Nexus as Manager) to a limited
liability company of which Nexus is manager and Michael J. Reidy and R. Darrell
Gary are majority members; provided that such assignment does not trigger any
adverse income tax consequences for the Company or its Members or cause an
acceleration on any loan for which the Company is obligated; provided, further,
that such assignee shall only become a Member upon the unanimous consent of the
other Members. In the event Michael Reidy and Darrell Gary cease to be majority
owners of such assignee, the assignee shall become an Economic Interest Owner
and shall no longer be a Member.

        4.3 WITHDRAWAL, RESIGNATION OR RETIREMENT. No Member may withdraw,
resign or retire from the Company except in the event of death. Upon the
occurrence of any event that would cause a person to cease to be a Member under
the Act, including a Dissolution Event when the business of the Company is
continued in accordance with Section 10.1 by the remaining Members, the
disassociated Member shall become an Economic Interest Owner in accordance with
Section 10.2.

                                      -13-
<PAGE>   21
        4.4 TRANSACTIONS WITH THE COMPANY. Subject to any limitations set forth
in this Agreement, a Member (or an Affiliate of a Member) may lend money to and
transact other business with the Company. Subject to other applicable law, such
Member (or an Affiliate of a Member) has the same rights and obligations with
respect thereto as a Person who is not a Member.

        4.5 REMUNERATION TO MEMBERS. Except as otherwise authorized pursuant to
this Agreement, no Member is entitled to remuneration for acting in the Company
business, subject to the entitlement of Members winding up the affairs of the
Company to reasonable compensation pursuant to Section 12.3.

        4.6 MEMBERS ARE NOT AGENTS. Pursuant to Section 5.1 and the Articles,
the management of the Company is vested in the Managers. No Member, acting
solely in the capacity of a Member, is an agent of the Company nor can any
Member in such capacity bind nor execute any instrument on behalf of the
Company.

        4.7 VOTING RIGHTS. Except as expressly provided in this Agreement or the
Articles, Members shall have no voting, approval or consent rights. Unless
otherwise specifically provided, in all matters in which a vote, approval or
consent of the Members is required, the vote, consent or approval of Members
holding at least two-thirds of the Membership Interests shall be required to
authorize or approve such act.

        4.8    MEETINGS OF MEMBERS.

                4.8.1 DATE, TIME AND PLACE OF MEETINGS OF MEMBERS; SECRETARY.
Meetings of Members may be held at such date, time and place within or without
the State of California as the Members may fix from time to time. No annual or
regular meetings of Members is required. At any Members' meeting, the Managers
shall appoint a person to preside at the meeting and a person to act as
secretary of the meeting.

                4.8.2 POWER TO CALL MEETINGS. Unless otherwise prescribed by the
Act or by the Articles, meetings of the Members may be called by the Managers,
or upon written demand of any Member for the purpose of addressing any matters
on which the Members may vote.

                4.8.3 NOTICE OF MEETING. The Managers shall give written notice
of a meeting of Members to each Member not less than 10 nor more than 60 days
before the date of the meeting. The notice shall specify the place, date and
hour of the meeting and the general nature of the business to be transacted. No
other business may be transacted at this meeting. If the meeting is called upon
written demand of Members entitled to call a meeting pursuant to Section 4.8.2,
the Managers shall give written notice of the meeting at a time requested by the
person calling the meeting, not less than 10 days nor more than 60 days after

                                      -14-
<PAGE>   22
the receipt of the request. If the notice is not given within 20 days after the
receipt of the request, the Members entitled to call the meeting may give the
notice.


                4.8.4 MANNER OF GIVING NOTICE. Notice of any meeting of Members
shall be given either personally or by first-class mail or other written
communication (including facsimile transmission), charges prepaid, addressed to
the Member at the address of that Member appearing on the books of the Company
or given by the Member to the Company for the purpose of notice. If no such
address appears on the Company's books or is given, notice shall be deemed to
have been given if sent to that Member by first-class mail or other written
communication to the Company's principal executive office. Notice shall be
deemed to have been given at the time when delivered personally or deposited in
the mail or sent by other means of written communication (including facsimile
transmission).

                4.8.5 VALIDITY OF ACTION. Any action approved at a meeting,
other than by unanimous approval of those entitled to vote, shall be valid only
if the general nature of the proposal so approved was stated in the notice of
meeting.

                4.8.6 QUORUM. The presence in person or by proxy of all Members
shall constitute a quorum at a meeting of Members. The Members present at a duly
called or held meeting at which a quorum is present may continue to do business
until adjournment, notwithstanding the loss of a quorum, if any action taken
after loss of a quorum (other than adjournment) is approved by all of the
Members. 

                4.8.7 ADJOURNED MEETING; NOTICE. Any Members' meeting, whether
or not a quorum is present, may be adjourned from time to time by the vote of
all of the Membership Interests represented at that meeting, either in person or
by proxy, but in the absence of a quorum, no other business may be transacted at
that meeting, except as provided in Section 4.8.6. When any meeting of Members
is adjourned to another time or place, notice need not be given of the adjourned
meeting if the time and place are announced at a meeting at which the
adjournment is taken, unless a new record date for the adjourned meeting is
subsequently fixed, or unless the adjournment is for more than 45 days from the
date set for the original meeting. At any adjourned meeting the Company may
transact any business which might have been transacted at the original meeting.

               4.8.8 WAIVER OF NOTICE OR CONSENT. The actions taken at any
meeting of Members however called and noticed, and wherever held, have the same
validity as if taken at a meeting duly held after regular call and notice, if a
quorum is present either in person or by proxy, and if, either before or after
the meeting, each of the Members entitled to vote, who was not present in person
or by proxy, signs a written waiver of notice or consents to the holding of the
meeting or approves the minutes of the meeting. Attendance of a person at a
meeting shall constitute a waiver of notice of that meeting, except when the
person objects, at the beginning of the meeting, to the transaction of any
business because the meeting is not lawfully called or convened, and except that
attendance at a meeting is not a waiver of any 


                                      -15-
<PAGE>   23


right to object to the consideration of matters not included in the notice of
the meeting if that objection is expressly made at the meeting. Neither the
business to be transacted nor the purpose of any meeting of Members need be
specified in any written waiver of notice.

                4.8.9 ACTION BY WRITTEN CONSENT WITHOUT A MEETING. Any action
that may be taken at a meeting of Members may be taken without a meeting, if a
consent in writing setting forth the action so taken is signed and delivered to
the Managers by all of the Members. Any Member giving a written consent, or the
Member's proxy holders, may revoke the consent by a writing received by the
Managers before written consents of the number of votes required to authorize
the proposed action have been filed.
 

                4.8.10 TELEPHONIC PARTICIPATION BY MEMBER AT MEETINGS. Members
may participate in any Members' meeting through the use of any means of
conference telephones or similar communications equipment as long as all Members
participating can hear one another. A Member so participating is deemed to be
present in person at the meeting.
                               

               4.8.11 RECORD DATE. In order that the Company may determine the
Members of record entitled to notices of any meeting or to vote, or entitled to
receive any distribution or to exercise any rights in respect of any
distribution or to exercise any rights in respect of any other lawful action,
the Managers (or, if they fail to do so, any Member) may fix, in advance, a
record date that is not more than 60 days nor less than 10 days prior to the
date of the meeting and not more than 60 days prior to any other action. If no
record date is fixed:

                         (i)   The record date for determining Members entitled 
to notice of or to vote at a meeting of Members shall be at the close of
business on the business day immediately preceding the day on which notice is
given or, if notice is waived, at the close of business on the business day
immediately preceding the day on which the meeting is held.

                        (ii)   The record date for determining Members entitled
to give consent to Company action in writing without a meeting shall be the day
on which the first written consent is given.

                       (iii)   The record date for determining Members for any 
other purpose shall be at the close of business on the day on which the Managers
adopt the resolution relating thereto, or the 60th day prior to the date of the
other action, whichever is later.

                        (iv)   The determination of Members of record entitled 
to notice of or to vote at a meeting of Members shall apply to any adjournment
of the meeting unless the Managers or the Members who called the meeting fix a
new record date for the adjourned meeting, but the Managers or the Members who
called the meeting shall fix a new record date if the meeting is adjourned for
more than 45 days from the date set for the original meeting.



                                      -16-
<PAGE>   24
               4.8.12   PROXIES. Every Member entitled to vote for the election
of Managers or on any other matter shall have the right to do so either in
person or by one or more agents authorized by a written proxy signed by the
person and filed with the Managers. A proxy shall be deemed signed if the
Member's name is placed on the proxy (whether by manual signature, typewriting,
telegraphic transmission, electronic transmission or otherwise) by the Member or
the Member's attorney in fact. A proxy may be transmitted by an oral telephonic
transmission if it is submitted with information from which it may be determined
that the proxy was authorized by the Member or the Member's attorney in fact. A
validly executed proxy which does not state that it is irrevocable shall
continue in full force and effect unless (i) revoked by the person executing it,
before the vote pursuant to that proxy, by a writing delivered to the Company
stating that the proxy is revoked, or by a subsequent proxy executed by, or
attendance at the meeting and voting in person by, the person executing the
proxy; or (ii) written notice of the death or incapacity of the maker of that
proxy is received by the Company before the vote pursuant to that proxy is
counted; provided, however, that no proxy shall be valid after the expiration of
11 months from the date of the proxy, unless otherwise provided in the proxy.
The revocability of a proxy that states on its face that it is irrevocable shall
be irrevocable as set forth therein, and the provisions of Corporations Code
Sections 705(e) and 705(f) shall not apply thereto.

                                    ARTICLE V
                      MANAGEMENT AND CONTROL OF THE COMPANY

     5.1 MANAGEMENT OF THE COMPANY BY MANAGERS.

               5.1.1    MANAGEMENT BY MANAGERS. The business, property and 
affairs of the Company shall be managed by the Managers. Except for situations
in which the approval of the Members is expressly required by this Agreement,
the Managers shall have full, complete and exclusive authority, power, and
discretion to manage and control the business, property and affairs of the
Company, to make all decisions regarding those matters, and to perform any and
all other acts or activities customary or incident to the management of the
Company's business, property and affairs. Unless otherwise specifically
provided, in all matters in which a vote, approval, consent or act of the
Managers is allowed or required, the vote, approval, consent or act of all of
the Managers shall be required to authorize or approve such act.

               5.1.2   AGENCY AUTHORITY OF MANAGERS.  Subject to Section 5.3.2,
either Manager is authorized to endorse checks, drafts, and other evidences of
indebtedness made payable to the order of the Company, but only for the purpose
of deposit into the Company's accounts. All checks, drafts, and other
instruments obligating the Company to pay money may be signed by either Manager,
and either Manager is authorized to sign contracts and obligations on behalf of
the Company.
                        



                                      -17-
<PAGE>   25

        5.2    ELECTION OF MANAGERS.

               5.2.1     NUMBER, TERM AND QUALIFICATIONS. The Company shall
initially have two Managers. The number of Managers of the Company may be
changed from time to time with the consent of Members holding at least
two-thirds of the Membership Interests, provided that in no instance shall there
be less than one Manager. Unless a Manager resigns or is removed, the Manager
shall hold office until a successor shall have been elected and qualified.
Managers shall be elected by the affirmative vote or written consent of Members
holding at least two-thirds of the Membership Interests; provided, however, that
Neurocrine acting alone may elect a Manager to replace Nexus at any time after
Nexus has received the entire distributions required pursuant to Section 7.1(i)
through (iv), and payments required by Sections 5.9 and 8.3, of this Agreement,
and Nexus and its Affiliates have been released from any personal liability by
all lenders who have made loans secured by the Premises. A Manager need not be a
Member or an individual.

               5.2.2     RESIGNATION. A Manager may resign at any time by giving
written notice to the Members without prejudice to the rights, if any, of the
Company under any contract to which the Manager is a party. The resignation of a
Manager shall take effect upon receipt of that notice or at such later time as
shall be specified in the notice; and, unless otherwise specified in the notice,
the acceptance of the resignation shall not be necessary to make it effective.
The resignation of a Manager who is also a Member shall not affect the Manager's
rights as a Member and shall not constitute a withdrawal of a Member, and
specifically shall not affect the right of Nexus to receive distributions under
Sections 7.1(i) through (iv), and payments required by Sections 5.9 and 8.3, of
this Agreement.

               5.2.3     REMOVAL. A Manager may be removed at any time, with or
without cause, by the affirmative vote or written consent of Members holding
two-thirds of the Membership Interests; provided, however, that Neurocrine
acting alone may remove Nexus as Manager at any time (i) after Nexus has
received the entire distributions required pursuant to Sections 7.1(i) through
(iv), and payments required by Sections 5.9 and 8.3, of this Agreement, and
Nexus and its Affiliates have been released from any personal liability by all
lenders who have made loans secured by the Premises, (ii) in the event Nexus
files for Bankruptcy, or (iii) in the event of Nexus' fraud, willful misconduct
or gross negligence. Any removal shall be without prejudice to the rights, if
any, of Nexus or an Affiliate of Nexus (i) under any brokerage agreement,
construction management agreement, property management agreement, or other
contract between the Company and Nexus or an Affiliate of Nexus, or (ii) to
collect payments under Sections 5.9. Furthermore, the removal of a Manager who
is also a Member shall not affect the Manager's rights as a Member and shall not
constitute a withdrawal of a Member, and specifically shall not affect the right
of Nexus to receive distributions under Sections 7.1(i) through (iv) of this
Agreement.



                                      -18-
<PAGE>   26

               5.2.4   VACANCIES.  Except as provided above, any vacancy 
occurring for any reason in position of Manager may be filled by the affirmative
vote or written consent of Members holding at least two-thirds of the Membership
Interests.
                       
        5.3    POWERS OF MANAGERS.

               5.3.1   POWERS OF MANAGERS.  Without limiting the generality of 
Section 5.1, but subject to the limitations of Section 5.3.2 and to the express
limitations set forth elsewhere in this Agreement, the Managers shall have all
necessary powers to manage and carry out the purposes, business, property, and
affairs of the Company, including, without limitation, the power to exercise on
behalf and in the name of the Company all of the powers described in
Corporations Code Section 17003. 

               5.3.2   LIMITATIONS ON POWER OF MANAGERS.  The Managers shall 
not have authority to cause the Company to engage in any of the following
transactions without first obtaining the affirmative vote or written consent of
Members holding at least two-thirds of the Membership Interests:
                       

                       (i)    The sale, exchange, leasing or other disposition 
of all or substantially all of the Company's assets, except for the development,
financing, and construction of the Premises, and except for the orderly
liquidation and winding up of the business of the Company upon its duly
authorized dissolution.

                       (ii)   The joint venture of the Company with another 
entity for any purpose.

                       (iii)  The merger of the Company with another entity; 
provided, in no event shall a Member be required to become a general partner in
a merger with a partnership without such Member's express written consent or
unless the agreement of merger provides each Member with the dissenter's rights
described in the Act.

                       (iv)   The establishment of different classes of Members.

                       (v)    An alteration of the primary purpose of the 
Company as set forth in Section 2.5.

                       (vi)   Any act which would make it impossible to carry on
the ordinary business of the Company.

                       (vii)  The confession of a judgment against the Company.

                       (viii) Any other transaction described in this Agreement
as requiring the vote, consent, or approval of the Members.



                                      -19-
<PAGE>   27

                       (ix)   Enter into contracts with the Company that would 
bind the Company after the expulsion, Bankruptcy, or other cessation to exist of
the Manager, or to continue the business of the Company after the occurrence of
such event.

                       (x)    Use or permit any other person to use Company 
funds or assets in any manner except for the exclusive benefit of the Company.

                       (xi)   Receive from the Company a rebate or give-up or 
participate in any reciprocal business arrangements which would enable it or any
Affiliate to do so.

                       (xii)  Borrowing or lending of any sum of money by the 
Company, the extension of credit or becoming a surety, guarantor, endorser or
accommodation maker except as set forth in Article III.

                       (xiii) Admit another person as a Manager.

                       (xiv)  Reinvest Distributable Cash in any additional
properties.

                       (xv)   Approval of any proposed settlement with the 
Internal Revenue Service or other taxing authority regarding any Company matter.

                       (xvi)  The approval of any loan documents, including all
construction loans and any loan documents which pledge any portion of the
Premises as security.

                       (xvii) The commencement, settlement, assignment, 
transfer, compromise, release or other action (including selection of counsel
for the Company) with respect to any claim of the Company or any legal,
judicial, arbitral or administrative proceeding with respect to any non-budget
claim; provided, however, that Neurocrine and Nexus, acting alone, shall have
the right to enforce the obligations of the other party under this Agreement.

                       (xviii) Selecting or varying accounting methods, filing 
of federal or state income tax returns or other income tax filings and making
other decisions with respect to treatment of items for accounting, financial
reporting, or federal or state income tax purposes, or other matters in
connection therewith.

                       (xvix)  Determining whether or not distributions should 
be made to the Members.

                       (xx)   Amendment of this Agreement.

                       (xxi) Dissolution of the Company.




                                      -20-
<PAGE>   28

                       (xxii) Any transaction with a Member, Manager or an
Affiliate.

                       (xxiii) Approval of agreements relating to the design 
and/or construction of the Building and Improvements, including, without
limitation, the budget for construction of the Building and Improvements, the
owner-contractor agreement, the owner-architect agreement, and any change
orders.

                       (xxiv) Matters relating to any lease affecting the
Premises.

        5.4    OBLIGATIONS OF THE MANAGERS.  The Managers shall:

               5.4.1   Exercise its management powers in order to carry out 
the purposes of the Company;

               5.4.2   Implement the transactions approved by the Members;

               5.4.3   Have a fiduciary responsibility to the Members in the 
same manner as a general partner would have to limited partners in a limited
partnership and for the safekeeping and use of all the funds and assets of the
Company, whether or not in its immediate possession or control;

               5.4.4   Keep all bank and other accounts and records in the name
of the Company;

               5.4.5   Devote such of its time and business efforts to the 
business of the Company as it shall in its discretion, exercised in good faith,
determine to be necessary to conduct the business of the Company for the benefit
of the Company and the Members;

               5.4.6   Cause the Company to be protected by public liability, 
property damage and other insurance determined by the Managers in their
discretion to be appropriate to the business of the Company;

               5.4.7   At all times use its best efforts to meet applicable 
requirements for the Company to be taxed as a partnership and not as an
association taxable as a corporation;

               5.4.8   Manage, operate and generally maintain the Company;

               5.4.9   Be responsible for and have authority to conduct the 
day to day operations of the Company; and

               5.4.10  Obtain insurance to the same extent and in the same 
amount as is required by any law, rule, or regulation of the State of California
that would be applicable to 




                                      -21-
<PAGE>   29

the Company were it a corporation organized and existing or duly qualified for
the transaction of intrastate business under the General Corporation Law.

        5.5    MEMBERS HAVE NO MANAGERIAL AUTHORITY.  The Members shall have no
power to participate in the management of the Company except as expressly
authorized by this Agreement or the Articles and except as expressly required by
the Act. Unless expressly and duly authorized in writing to do so by the
Manager, no Member shall have any power or authority to bind or act on behalf of
the Company in any way, to pledge its credit, or to render it liable for any
purpose.
               

        5.6    PERFORMANCE OF DUTIES; LIABILITY OF MANAGERS. No Manager shall be
liable to the Company or to any Member for any loss or damage sustained by the
Company or any Member, unless the loss or damage shall have been the result of
fraud, deceit, gross negligence, reckless or intentional misconduct or a knowing
violation of law by the Manager. The Managers shall perform their managerial
duties in good faith, in a manner it reasonably believes to be in the best
interests of the Company and its Members, and with such care, including
reasonable inquiry, as an ordinarily prudent person in a like position would use
under similar circumstances. No Manager shall have any liability by reason of
being or having been a Manager of the Company. In performing their duties, each
Manager shall be entitled to rely on information, opinions, reports, or
statements, including financial statements and other financial data, of any
attorney, independent accountant, or other licensed person as to matters which
the Manager reasonably believes to be within such person's professional or
expert competence, unless the Manager has knowledge concerning the matter in
question that would cause such reliance to be unwarranted, and provided that the
Manager acts in good faith and after reasonable inquiry when the need therefor
is indicated by the circumstances.

        5.7    DEVOTION OF TIME.  No Manager is obligated to devote all of its
time or business efforts to the affairs of the Company. The Managers shall
devote whatever time, effort, and skill as they deem appropriate for the
operation of the Company. 

        5.8    COMPETING ACTIVITIES. Any Manager and its officers, directors,
shareholders, agents, employees and Affiliates may engage or invest in,
independently or with others, any business activity of any type or description,
including without limitation those that might be the same as or similar to the
Company's business and that might be in direct or indirect competition with the
Company. Neither the Company nor any Member shall have any right in or to such
other ventures or activities or to the income or proceeds derived therefrom. No
Manager shall be obligated to present any investment opportunity or prospective
economic advantage to the Company, even if the opportunity is of the character
that, if presented to the Company, could be taken by the Company. A Manager
shall have the right to hold any investment opportunity or prospective economic
advantage for its own account or to recommend such opportunity to Persons other
than the Company. The Members acknowledge that the Managers and their Affiliates
own and/or manage other businesses, including businesses that may compete with
the Company and for the Manager's time. The Members 



                                      -22-
<PAGE>   30

hereby waive any and all rights and claims which they may otherwise have against
the Managers and their officers, directors, shareholders, agents, employees, and
Affiliates as a result of any of such activities.

        5.9    TRANSACTIONS BETWEEN THE COMPANY AND THE MANAGERS. A Manager or 
an Affiliate of the Manager may engage in any transaction (including, without
limitation, the purchase, sale, lease, or exchange of any property or the
rendering of any service, or the establishment of any salary, other
compensation, or other terms of employment) with the Company so long as the
terms and conditions of such transaction are approved by all of the Members. The
Members agree that Nexus or an Affiliate of Nexus shall provide development
services and receive compensation equal to *** from the Tokai Construction
Loan (the "general administration" or "g&a" line item on the pro forma which
serves as the basis for any construction loan and which shall be paid out of the
Tokai Construction Loan amortized over the estimated construction period).

        5.10   ACTS OF MANAGERS AS CONCLUSIVE EVIDENCE OF AUTHORITY.  Any note,
mortgage, evidence of indebtedness, lease, contract, certificate, statement,
conveyance, or other instrument or document in writing, and any assignment or
endorsement thereof, executed or entered into between the Company and any other
person, when signed by either Manager acting alone, is not invalidated as to the
Company by any lack of authority of the Manager in the absence of actual
knowledge on the part of the other person that the Manager had no authority to 
execute the same.

        5.11    LIMITED LIABILITY. No Manager shall be personally liable under
a ny judgment of a court, or in any other manner, for any debt, obligation, or
liability of the Company, whether that liability or obligation arises in
contract, tort, or otherwise, solely by reason of being a Manager.

        5.12   RESOLUTION OF DISPUTES.  In the event of a disagreement between 
the Managers on a matter requiring the approval or consent of both Managers, the
dispute shall be submitted to binding arbitration in accordance with Section
15.9 hereof. In resolving any dispute, the arbitrator shall apply the standard
of what an institutional owner of real property acting in a commercially
reasonable manner would do under similar circumstances.
               

                                   ARTICLE VI
                     ALLOCATIONS OF NET INCOME AND NET LOSS


        6.1    ALLOCATION OF NET INCOME AND NET LOSS FROM OPERATIONS.  For each
fiscal year, (i) Net Income from operations of the Company shall be allocated to
***.

* confidential treatment
 


                                      -23-
<PAGE>   31

        6.2    ALLOCATION OF NET INCOME AND NET LOSS FROM SALE OR EXCHANGE. For 
each fiscal year, the Net Income and Net Loss from sale or exchange of the
Premises shall be allocated as follows:
   
               6.2.1   NET INCOME ALLOCATIONS.***

                       (i)***

                       (ii)***

                       (iii)***

                       (iv)***

               6.2.2   NET LOSS ALLOCATIONS.***
                       
        6.3    SPECIAL ALLOCATIONS.

               6.3.1 QUALIFIED INCOME OFFSET. Except as provided in Section
6.3.3, in the event any Member unexpectedly receives any adjustments,
allocations, or distributions described in Treasury Regulations Sections
1.704-1(b)(2)(ii)(d)(4), 1.704-1(b)(2)(ii)(d)(5) or 1.704-1(b)(2)(ii) (d)(6),
items of Company income and gain shall be specially allocated to such Member in
an amount and manner sufficient to eliminate, to the extent required by the
Treasury Regulations, the Adjusted Capital Account Deficit created by such
adjustment, allocation or distribution as quickly as possible.

* confidential treatment

                                      -24-
<PAGE>   32

               6.3.2   GROSS INCOME ALLOCATION.  Net Loss shall not be allocated
to any Member to the extent such allocation would cause any Member to have an
Adjusted Capital Account Deficit at the end of a fiscal year. In the event any
Member has an Adjusted Capital Account Deficit at the end of any fiscal year,
each such Member shall be specially allocated items of Company gross income and
gain in the amount of such Adjusted Capital Account Deficit as quickly as
possible.

               6.3.3 COMPANY MINIMUM GAIN CHARGEBACK. Notwithstanding any other
provision of this Section 6, if there is a net decrease in Company Minimum Gain
during any fiscal year, each Member shall be specially allocated items of
Company income and gain for such year (and, if necessary, subsequent years) in
an amount equal to such Member's share of the net decrease in Company Minimum
Gain, determined in accordance with Treasury Regulations Section 1.704-2(g)(2).
This Section 6.3.3 is intended to comply with the Company Minimum Gain
chargeback requirement in the Treasury Regulations and shall be interpreted
consistently therewith. This provisions shall not apply to the extent the
Member's share of net decrease in Company Minimum Gain is caused by a guaranty,
refinancing, or other change in the debt instrument causing it to become
partially or wholly recourse debt or Member Nonrecourse Debt, and such Member
bears the economic risk of loss (within the meaning of Treasury Regulations
Section 1.752-2 for the newly guaranteed, refinanced or otherwise changed debt
or to the extent the Member contributes cash to the capital of the Company that
is used to repay the Nonrecourse Debt, and the Member's share of the net
decrease in Company Minimum Gain results from the repayment.

               6.3.4 MEMBER MINIMUM GAIN CHARGEBACK. Notwithstanding any other
provision of this Section 6, except Section 6.3.3, if there is a net decrease in
Member Minimum Gain, any Member with a share of that Member Minimum Gain (as
determined under Treasury Regulations Section 704-2(i)(5)) as of the beginning
of the year shall be allocated items of Company income and gain for such year
(and, if necessary, subsequent years) in an amount equal to such Member's share
of the net decrease in Member Minimum Gain, determined in accordance with
Treasury Regulations Section 1.704-2(g)(2). This Section shall not apply to the
extent the net decrease in Member Minimum Gain arises because the liability
ceases to be Member Nonrecourse Debt due to conversion, refinancing or other
change in a debt instrument that causes it to become partially or wholly a
Nonrecourse Debt. This Section is intended to comply with the Member Minimum
Gain chargeback requirements in the Treasury Regulations and shall be
interpreted consistently therewith and applied with the restrictions
attributable thereto.

               6.3.5   NONRECOURSE DEDUCTIONS.  Nonrecourse Deductions for any
fiscal year or other period shall be allocated 100% to Neurocrine.

               6.3.6 MEMBER NONRECOURSE DEDUCTIONS. Member Nonrecourse
Deductions for any fiscal year shall be allocated to the Member who bears the
economic risk of loss as set forth in Treasury Regulations Section 1.752-2 with
respect to the Member Nonrecourse 



                                      -25-
<PAGE>   33

Debt. If more than one Member bears the economic risk of loss for a Member
Nonrecourse Debt, any Member Nonrecourse Deductions attributable to that Member
Nonrecourse Debt shall be allocated among the Members according to the ratio in
which they bear the economic risk of loss.

               6.3.7 CODE SECTION 754 ADJUSTMENTS. To the extent an adjustment
to the adjusted tax basis of any Company asset pursuant to Code Section 734(b)
or Code Section 743(b) is required, pursuant to Treasury Regulations Section
1.704-1(b)(2)(iv)(m), to be taken into account in determining Capital Accounts,
the amount of such adjustment to the Capital Accounts shall be treated as an
item of gain (if the adjustment increases the basis of the asset) or loss (if
the adjustment decreases such basis), and such gain or loss shall be specially
allocated to the Members in a manner consistent with the manner in which their
Capital Accounts are required to be adjusted pursuant to such section of the
Treasury Regulations.

               6.3.8   CURATIVE ALLOCATIONS.  Notwithstanding any other 
provision of this Agreement, the Regulatory Allocations shall be taken into
account in allocating items of income, gain, loss and deduction among the
Members so that, to the extent possible, the net amount of such allocations of
other items and the Regulatory Allocations to each Member shall be equal to the
net amount that would have been allocated to each such Member if the Regulatory
Allocations had not occurred.
                          

        6.4    CONTRIBUTED PROPERTY.  Notwithstanding any other provision of 
this Section 6 to the contrary, the Members shall cause depreciation and cost
recovery deductions and gain or loss attributable to Property contributed by a
Member or revalued by the Company to be allocated among the Members for income
tax purposes in accordance with Section 704(c) of the Code and the Treasury
Regulations promulgated thereunder.

                                   ARTICLE VII
                                  DISTRIBUTIONS

        7.1    DISTRIBUTION OF DISTRIBUTABLE CASH FROM SALE OR EXCHANGE OF THE 
PREMISES.***

* confidential treatment

                                      -26-
<PAGE>   34
                                      ***


                                      -27-

* confidential treatment
<PAGE>   35

        7.3    PERSONS TO RECEIVE DISTRIBUTIONS.  All distributions shall be 
made only to the Persons who, according to the books and records of the Company,
are the holders of record of the Economic Interests in respect of which such
distributions are made on the actual date of distribution. Neither the Company
nor the Members shall incur any liability for making distributions in accordance
with this Section 7.3.
                

        7.4    FORM OF DISTRIBUTION.  A Member or Economic Interest Owner has 
no right to demand and receive any distribution from the Company in any form
other than money. No Member or Economic Interest Owner may be compelled to
accept from the Company a distribution of any asset in kind in lieu of a
proportionate distribution of money being made to other Members. Except upon a
dissolution and the winding up of the Company, no Member or Economic Interest
Owner may be compelled to accept a distribution of any asset in kind.

        7.5    RESTRICTION ON DISTRIBUTIONS.

               7.5.1   INSUFFICIENT ASSETS.  No distribution shall be made if, 
after giving effect to the distribution, (i) the Company would not be able to
pay its debts as they become due in the usual course of business, or (ii) the
Company's total assets would be less than the sum of its total liabilities.

               7.5.2   BASIS OF DETERMINATION. The Members may base a
determination that a distribution is not prohibited on any of the following: (i)
financial statements prepared on the basis of accounting practices and
principles that are reasonable in the circumstances; (ii) a fair valuation; or
(iii) any other method that is reasonable in the circumstances. Except as
provided in Section 17254(e) of the Corporations Code, the effect of a
distribution is measured as of the date the distribution is authorized if the
payment occurs within 120 days after the date of authorization, or the date
payment is made if it occurs more than 120 days after the date of authorization.

        7.6    RETURN OF DISTRIBUTIONS.  Except for distributions made in 
violation of the Act or this Agreement, no Member or Economic Interest Owner
shall be obligated to return any distribution to the Company or pay the amount
of any distribution for the account of the Company or to any creditor of the
Company. The amount of any distribution returned to the Company by a Member or
Economic Interest Owner or paid by a Member or Economic Interest Owner for the
account of the Company or to a creditor of the Company shall be added to the
account or accounts from which it was subtracted when it was distributed to the
Member or Economic Interest Owner.

        7.7    OBLIGATIONS OF MEMBERS TO REPORT ALLOCATIONS.  The Members are 
aware of the income tax consequences of the allocations made by this Article VI
and hereby agree to be bound by the provisions of this Article VI in reporting
their shares of Company income and loss for income tax purposes. Further, the
Members agree to treat the Company as the 




                                      -28-
<PAGE>   36

owner of the Premises for income tax purposes and agree not to take any position
that is inconsistent with such treatment for income tax purposes.

                                  ARTICLE VIII

              COMPENSATION TO THE MANGERS, MEMBERS AND AFFILIATES

      8.1 COMPENSATION OF MEMBERS. The Members, the Managers and their
Affiliates shall receive compensation from the Company for services rendered or
to be rendered only as specified in this Agreement.

      8.2 COMPANY EXPENSES.

               8.2.1   OPERATING EXPENSES. Subject to the limitations set forth 
in Section 8.2.2, the Company shall pay directly, or reimburse the Members as
the case may be, for all of the costs and expenses of the Company's operations.

               8.2.2   OVERHEAD OF MANAGERS.  No Manager, Member nor any 
Affiliate shall be reimbursed for overhead expenses incurred in connection with
the business of the Company.

        8.3 PAYMENTS TO NEXUS. Nexus shall receive a Development Services Fee of
*** per year or *** per month beginning the first day of the month following the
later of the Lease Commencement Date or the date upon which Tokai Bank is
willing to fund the Permanent Loan and terminating at the earlier of (i) the
time, if at all, that Neurocrine purchases Nexus' membership interest pursuant
to Section 9.5, or purchases the Premises pursuant to the Option Agreement, or
(ii) the sale, exchange or transfer of the Project. Notwithstanding the above,
the *** amount shall be reduced to *** in the event Nexus has received the
Preferred Return and a cumulative amount of *** (excluding distributions
allocable to the Preferred Capital Return and the Unreturned Capital
Contribution) and Nexus and its Affiliates have been released from any personal
liability by all lenders who have made loans secured by the Premises. The ***
annual amount shall be increased on each anniversary date of the first payment
by *** over the amount of the fee for the prior year. The *** increase described
in the immediately preceding sentence shall not apply to the Development Service
Fee if and when the fee is reduced to ***. If due to the acts of Neurocrine, any
payment required hereunder is not paid within 10 days of the date due, it shall
thereafter bear interest at the rate of 8.5% until paid.


                                   ARTICLE IX
                      TRANSFER AND ASSIGNMENT OF INTERESTS

           9.1 TRANSFER AND ASSIGNMENT OF INTERESTS. No Member shall be entitled
to transfer, assign, convey, sell, encumber or in any way alienate all or any
part of such Member's Membership Interest without the prior written consent of
the other Members, which


* confidential treatment

                                      -29-

<PAGE>   37

consent may be given, withheld, conditioned or delayed as the other Members may
determine in their sole discretion; provided, however, that Neurocrine may
transfer its Membership Interest to any entity by which it is acquired, or into
which it is merged or consolidated, or to which it has sold all or substantially
all of its assets. Transfers in violation of this Article X shall only be
effective to the extent set forth in Section 9.4. After the consummation of any
transfer of any part of a Membership Interest, the Membership Interest so
transferred shall continue to be subject to the terms and provisions of this
Agreement and any further transfers shall be required to comply with all the
terms and provisions of this Agreement.

        9.2 FURTHER RESTRICTIONS ON TRANSFER OF INTERESTS. In addition to other
restrictions found in this Agreement, no Member shall transfer, assign, convey,
sell, encumber or in any way alienate all or any part of such Member's
Membership Interest (i) without compliance with Section 14.10, (ii) if the
Membership Interest to be transferred, assigned, sold or exchanged, when added
to the total of all other Membership Interests sold or exchanged in the
preceding 12 consecutive months prior thereto, would cause the termination of
the Company under the Code, or (iii) if the Membership Interest to be
transferred, assigned, sold or exchanged, when added to the total of all other
Membership Interests sold or exchanged prior thereto, would cause a reassessment
of the Premises as a "change of ownership" under the California Revenue and
Taxation Code. Any transferee of a Membership Interest shall take subject to the
restrictions on transfer imposed by this Agreement.

        9.3 SUBSTITUTION OF MEMBERS. A transferee of a Membership Interest shall
have the right to become a Substituted Member only if (i) the requirements of
Sections 9.1 and 9.2, and the requirements of applicable securities and tax laws
are met, (ii) such Person executes an instrument satisfactory to the Managers
accepting and adopting the terms and provisions of this Agreement, (iii) such
Person pays any reasonable expenses in connection with admission as a new
Member, and (iv) the written consent of Members holding at least two-thirds of
the other Membership Interests is obtained to admit the Economic Interest Owner
as a Substituted Member; provided, however, that any permitted transferee of
Neurocrine described in the proviso to the first sentence of Section 9.1 shall
automatically be admitted as a Substituted Member upon completion of such
transfer and compliance with clauses (i) through (iii) of this sentence. The
granting or withholding of such consent shall be within the sole and absolute
discretion of the other Members. The admission of a Substituted Member shall not
result in the release of the Member who assigned the Membership Interest from
any liability that such Member may have to the Company.

        9.4 NO EFFECT TO TRANSFERS IN VIOLATION OF AGREEMENT. Upon any transfer
of a Membership Interest in violation of this Article IX, the transferee shall
have no right to vote or participate in the management of the business, property
and affairs of the Company or to exercise any rights of a Member. Such
transferee shall only be entitled to become an Economic Interest Owner and
thereafter shall only receive the share of one or more of the Company's Net
Income, Net Losses and distributions of the Company's assets to which the


                                      -30-
<PAGE>   38

transferor of such Economic Interest would otherwise be entitled.
Notwithstanding the immediately preceding sentences, if a transfer in violation
of this Article IX would cause the termination of the Company under the Code, or
a reassessment of the Premises under the California Revenue and Taxation Code,
the transfer shall be null and void and the purported transferee shall not
become either a Member or an Economic Interest Owner.

        9.5 TRANSFER OF NEXUS' INTEREST TO NEUROCRINE. The entire Membership
Interest of Nexus and Crocker shall automatically become Neurocrine's interest
upon Neurocrine's payment of $1.00 to Nexus and Crocker at any time after Nexus
(A) has received the entire distribution required pursuant to Sections 7.1(i)
through (iv), (B) Nexus has received any payments due Nexus under Sections 5.9
and 8.3 of this Agreement and (C) Nexus and any Affiliate, are released from any
guaranty or personal liability for any loans to the Company, including any
construction or permanent loan secured by the Premises. Notwithstanding any
other provision of this Agreement, Neurocrine shall have the power and authority
to refinance any indebtedness on the Premises without any other Member's or the
Manager's consent as long as the proceeds of such financing would allow the
Company to satisfy the conditions set forth in this Section. If, by the end of
the 9th year of the term of the Neurocrine Lease, the Membership Interest of
Nexus does not become Neurocrine's Membership Interest under the terms of this
Section 9.5 or Neurocrine does not exercise its right to purchase the Premises
under the Option Agreement, Neurocrine shall extend the term of the Neurocrine
Lease for one period of five years pursuant to Section 40 of the Neurocrine
Lease.

                                    ARTICLE X
                       CONSEQUENCES OF DEATH, DISSOLUTION,
                       RETIREMENT OR BANKRUPTCY OF MEMBER


        10.1   DISSOLUTION EVENT.  Upon the occurrence of a Dissolution Event, 
the Company shall dissolve unless the remaining Members holding at least
two-thirds of the Membership Interests consent within 90 days of the Dissolution
Event to the continuation of the business of the Company.

        10.2   NO EFFECT IF VIOLATION OF AGREEMENT. If the remaining Members
consent to the continuation of the business of the Company in accordance with
Section 10.1, the Member subject to the dissolution event shall thereafter have
no right to vote or participate in the management of the business, property and
affairs of the Company or to exercise any rights of a Member. Such transferee
shall only be entitled to become an Economic Interest Owner and thereafter shall
only receive the share of one or more of the Company's Net Income, Net Loss and
distributions of the Company's assets to which the transferor of such Economic
Interest would otherwise be entitled.




                                      -31-
<PAGE>   39

                                          ARTICLE XI
                           ACCOUNTING, RECORDS, REPORTING BY MEMBERS

        11.1   BOOKS AND RECORDS.  The books and records of the Company shall 
be kept, and the financial position and the results of its operations recorded,
in accordance with the accounting methods followed for federal income tax
purposes. The books and records of the Company shall reflect all the Company
transactions and shall be appropriate and adequate for the Company's business.
The Company shall maintain at its principal office in California all of the
following:
               

               A.      A current list of the full name and last known business
or residence address of each Member and Economic Interest Owner set forth in
alphabetical order, together with the Capital Contributions, Capital Account and
Percentage Interest of each Member and Economic Interest Owner;

               B.      A current list of the full name and business or residence
address of each Manager;

               C.      A copy of the Articles and any and all amendments thereto
together with executed copies of any powers of attorney pursuant to which any
amendments to the Articles have been executed;

               D.      Copies of the Company's federal, state, and local income
tax or information returns and reports, if any, for the six most recent taxable
years;

               E.      A copy of this Agreement and any and all amendments
thereto together with executed copies of any powers of attorney pursuant to
which this Agreement or any amendments thereto have been executed;

               F.      Copies of the financial statements of the Company, if 
any, for the six most recent Fiscal Years; and

               G.      The Company's books and records as they relate to the 
internal affairs of the Company for at least the current and past four Fiscal
Years.

        11.2   DELIVERY TO MEMBERS AND INSPECTION.

               11.2.1         REQUESTS FOR INFORMATION.  Upon the request of 
any Member or Economic Interest Owner for purposes reasonably related to the
interest of that Person as a Member or Economic Interest Owner, the Managers
shall promptly deliver to the requesting Member or Economic Interest Owner, at
the expense of the Company, a copy of the information required to be maintained
by Sections 11.1A through F.


                                      -32-
<PAGE>   40

               11.2.2         INSPECTION OF RECORDS.  Each Member, Manager and 
Economic Interest Owner has the right, upon reasonable request for purposes
reasonably related to the interest of the Person as Member, Manager or Economic
Interest Owner, to inspect and copy during normal business hours any of the
Company records described at Sections 11.1A through G.

               11.2.3         INSPECTION BY REPRESENTATIVE.  Any request, 
inspection or copying by a Member or Economic Interest Owner under this Section
11.2 may be made by that Person or that Person's agent or attorney.


        11.3   FINANCIAL STATEMENTS/TAX RETURNS.

               11.3.1         ANNUAL STATEMENTS.  Neurocrine as Manager shall 
cause annual income statements and balance sheets to be prepared and sent to
each of the Members as soon as reasonably practicable after the close of each
Fiscal Year reflecting the financial position of the Company for such Fiscal
Year.

               11.3.2         TAX RETURNS.  Neurocrine as Manager shall cause 
to be prepared after the end of each Fiscal Year information necessary for the
preparation of the Members' and Economic Interest Owners' federal and state
income tax returns.


               11.3.3         ANNUAL STATUTORY REPORT.  Neurocrine as Manager
shall cause to be filed at least annually with the California Secretary of State
the statement required under California Corporations Code Section 17060.

        11.4   FILINGS. Neurocrine as Manager shall cause the income tax returns
for the Company to be prepared and timely filed with the appropriate
authorities. Neurocrine shall also cause to be prepared and timely filed, with
appropriate federal and state regulatory and administrative bodies, amendments
to, or restatements of, the Articles and all reports required to be filed by the
Company with those entities under the Act or other then current applicable laws,
rules, and regulations. If Neurocrine as Manager is required by the Act to
execute or file any document and fails, after demand, to do so within a
reasonable period of time, or refuses to do so, the other Manager or any Member
may prepare, execute and file that document with the California Secretary of
State.

        11.5   BANK ACCOUNTS.  The Managers shall maintain the funds of the 
Company in one or more separate bank accounts in the name of the Company, and
shall not permit the funds of the Company to be commingled in any fashion with
the funds of any other Person.

        11.6   ACCOUNTING DECISIONS AND RELIANCE ON OTHERS.  All decisions as 
to accounting matters, except as otherwise specifically set forth herein, shall
be made by the Members. The Members may rely upon the advice of their
accountants as to whether such 



                                      -33-
<PAGE>   41

decisions are in accordance with accounting methods followed for federal income
tax purposes.

        11.7 TAX MATTERS FOR THE COMPANY HANDLED BY MEMBERS AND TAX MATTERS
PARTNER. The Members shall from time to time cause the Company to make such tax
elections as they deem to be in the best interests of the Company. The Tax
Matters Partner, as defined in Code Section 6231, shall represent the Company
(at the Company's expense) in connection with all examinations of the Company's
affairs by tax authorities, including resulting judicial and administrative
proceedings, and shall expend the Company funds for professional services and
costs associated therewith. The Tax Matters Partner shall oversee the Company
tax affairs in the overall best interests of the Company. If for any reason the
Tax Matters Partner can no longer serve in that capacity or ceases to be a
Member or Manager, as the case may be, Members may designate another to be Tax
Matters Partner. The Company shall take the position that it is a "partnership"
for federal income tax purposes, and shall not file any federal income tax
election or other document that is inconsistent with such position.

                                   ARTICLE XII
                           DISSOLUTION AND WINDING UP

        12.1   DISSOLUTION.  The Company shall be dissolved, its assets shall 
be disposed of, and its affairs wound up on the first to occur of the following:

               A.      Upon the happening of any event of dissolution specified
 in the Articles;

               B.      Upon the entry of a decree of judicial dissolution 
pursuant to Section 17351 of the Corporations Code;

               C.      The occurrence of a Dissolution Event and the failure 
of the remaining Members to consent in accordance with Section 10.1 to continue
the business of the Company within 90 days after the occurrence of such event;
or

               D.      The sale of all or substantially all of the assets of
Company.

        12.2   CERTIFICATE OF DISSOLUTION.  As soon as possible following the 
occurrence of any of the events specified in Section 12.1, the Manager who has
not wrongfully dissolved the Company or, if none, the Members, shall execute a
Certificate of Dissolution in such form as shall be prescribed by the California
Secretary of State and file the Certificate as required by the Act.

        12.3   WINDING UP. Upon the occurrence of any event specified in 
Section 12.1, the Company shall continue solely for the purpose of winding up
its affairs in an orderly manner, 




                                      -34-
<PAGE>   42

liquidating its assets, and satisfying the claims of its creditors. The Manager
who has not wrongfully dissolved the Company or, if none, the Members, shall be
responsible for overseeing the winding up and liquidation of Company, shall take
full account of the liabilities of Company and assets, shall either cause its
assets to be sold or distributed, and if sold as promptly as is consistent with
obtaining the fair market value thereof, shall cause the proceeds therefrom, to
the extent sufficient therefor, to be applied and distributed as provided in
Section 12.5. The Persons winding up the affairs of the Company shall give
written notice of the commencement of winding up by mail to all known creditors
and claimants whose addresses appear on the records of the Company. The Manager
or Members winding up the affairs of the Company shall be entitled to reasonable
compensation for such services. 12.4 DISTRIBUTIONS IN KIND. Without the consent
of Members holding at least two-thirds of the Membership Interests, all
distributions to Members shall be in cash. Any non-cash asset distributed to one
or more Members shall first be valued at its fair market value to determine the
Net Profit or Net Loss that would have resulted if such asset were sold for such
value, such Net Profit or Net shall then be allocated pursuant to Article VI,
and the Members' Capital Accounts shall be adjusted to reflect such allocations.
The amount distributed and charged to the Capital Account of each Member
receiving an interest in such distributed asset shall be the fair market value
of such interest (net of any liability secured by such asset that such Member
assumes or takes subject to). The fair market value of such asset shall be
determined by the Members or if there is no agreement within thirty (30) days by
an independent appraiser (any such appraiser must be recognized as an expert in
valuing the type of asset involved) selected by the Members or liquidating
trustee. 12.5 ORDER OF PAYMENT OF LIABILITIES UPON DISSOLUTION. 12.5.1
DISTRIBUTION TO MEMBERS. After determining that all known debts and liabilities
of the Company in the process of winding-up, including, without limitation,
debts and liabilities to Members who are creditors of the Company, including
payments required pursuant to Section 8.3, have been paid or adequately provided
for, the remaining assets shall be distributed to the Members and Nexus in
accordance with Section 7.1. Such liquidating distributions shall be made by the
end of the Company's taxable year in which the Company is liquidated, or, if
later, within 90 days after the date of such liquidation.

               12.5.2  PROVISION FOR LIABILITIES.  The payment of a debt or
liability, whether the whereabouts of the creditor is known or unknown, has been
adequately provided for if the payment has been provided for by either of the
following means:


                       (i)    Payment thereof has been assumed or guaranteed 
in good faith by one or more financially responsible persons or by the United
States government or any agency thereof and the provision, including the
financial responsibility of the Person, was determined in good faith and with
reasonable care by the Members to be adequate at the time of any distribution of
the assets pursuant to this Section.



                                      -35-
<PAGE>   43

                       (ii)   The amount of the debt or liability has been 
deposited as provided in Section 2008 of the Corporations Code.

        This Section 12.5.2 shall not prescribe the exclusive means of making
adequate provision for debts and liabilities.

        12.6   COMPLIANCE WITH REGULATIONS.  All payments to the Members upon 
the winding and dissolution of Company shall be strictly in accordance with the
positive capital account balance limitation and other requirements of
Regulations Section 1.704-1(b)(2)(ii)(d).

        12.7   LIMITATIONS ON PAYMENTS MADE IN DISSOLUTION.  Except as 
otherwise specifically provided in this Agreement, each Member shall only be
entitled to look solely at the assets of Company for the return of the Member's
positive Capital Account balance and shall have no recourse for the Member's
Capital Contribution and/or share of Net Income (upon dissolution or otherwise)
against the Manager or any other Member except as provided in Article XIII.

        12.8   CERTIFICATE OF CANCELLATION.  The Manager or Members who filed 
the Certificate of Dissolution shall cause to be filed in the office of, and on
a form prescribed by, the California Secretary of State, a certificate of
cancellation of the Articles upon the completion of the winding up of the
affairs of the Company.

        12.9   NO ACTION FOR DISSOLUTION.  Except as expressly permitted in 
this Agreement, a Member shall not take any voluntary action that directly
causes a Dissolution Event. The Members acknowledge that irreparable damage
would be done to the goodwill and reputation of the Company if any Member should
bring an action in court to dissolve the Company under circumstances where
dissolution is not required by Section 12.1. This Agreement has been drawn
carefully to provide fair treatment of all parties and equitable payment in
liquidation of the Economic Interests. Accordingly, except where the Managers
have failed to liquidate the Company as required by this Article XII, each
Member hereby waives and renounces the Member's right to initiate legal action
to seek the appointment of a receiver or trustee to liquidate the Company or to
seek a decree of judicial dissolution of the Company on the ground that (a) it
is not reasonably practicable to carry on the business of the Company in
conformity with the Articles or this Agreement, or (b) dissolution is reasonably
necessary for the protection of the rights or interests of the complaining
Member. Damages for breach of this Section 12.9 shall be monetary damages only
(and not specific performance), and the damages may be offset against
distributions by the Company to which such Member would otherwise be entitled.




                                      -36-
<PAGE>   44


                                  ARTICLE XIII
                          INDEMNIFICATION AND INSURANCE

        13.1    INDEMNIFICATION OF AGENTS. The Company shall indemnify any 
Person who was or is a party or is threatened to be made a party to any
threatened, pending or completed action, suit or proceeding by reason of the
fact that such Person is or was a Member, Manager, officer, employee or other
agent of the Company (all such Persons being referred to hereinafter as an
"agent"), to the extent the claims underlying the action, suit or proceeding are
based on the agent's scope of employment or agency, or on the agent's good faith
discharge of duties under this Agreement, and which were not the result of gross
negligence, willful misconduct or breach of this Agreement or the terms of any
employment or agency. The Managers shall be authorized, on behalf of the
Company, to enter into indemnity agreements from time to time with any Person
entitled to be indemnified by the Company hereunder, upon such terms and
conditions as the Managers deem appropriate in its reasonable business judgment.

        13.2    INSURANCE.  The Company shall have the power to purchase and 
maintain insurance on behalf of any Person who is or was an agent of the Company
against any liability asserted against such Person and incurred by such Person
in any such capacity, or arising out of such Person's status as an agent,
whether or not the Company would have the power to indemnify such Person against
such liability under the provisions of Section 13.1 or under applicable law.

                                   ARTICLE XIV

                           INVESTMENT REPRESENTATIONS

        Each Member hereby represents and warrants to, and agrees with, the
Manager, the other Members, and the Company as follows:

        14.1    PREEXISTING RELATIONSHIP OR EXPERIENCE. (i) The Member has a
preexisting personal or business relationship with the Company or one or more of
its officers or control persons or the Managers or (ii) by reason of the
Member's business or financial experience, or by reason of the business or
financial experience of the Member's financial advisor who is unaffiliated with
and who is not compensated, directly or indirectly, by the Company or any
affiliate or selling agent of the Company, the Member is capable of evaluating
the risks and merits of an investment in the Membership Interest and of
protecting the Member's own interests in connection with this investment.

        14.2    NO ADVERTISING.  The Member has not seen, received, been 
presented with, or been solicited by any leaflet, public promotional meeting,
newspaper or magazine article or advertisement, radio or television
advertisement, or any other form of advertising or general solicitation with
respect to the sale of the Membership Interest.


                                      -37-
<PAGE>   45

        14.3   INVESTMENT INTENT.  The Member is acquiring the Membership 
Interest for investment purposes for the Member's own account only and not with
a view to or for sale in connection with any distribution of all or any part of
the Membership Interest. No other person will have any direct or indirect
beneficial interest in or right to the Membership Interest other than a
shareholder of a corporation which is a Member or a beneficiary of a trust which
is a Member.
        
        14.4   PURPOSE OF ENTITY.  If the Member is a corporation, partnership,
limited liability company, trust, or other entity, it was not organized for the
specific purpose of acquiring the Membership Interest.
 
        14.5   RESIDENCY. The Member is a resident of the state of California.

        14.6   ECONOMIC RISK.  The Member is financially able to bear the 
economic risk of an investment in the Membership Interest, including the total
loss thereof.

        14.7   NO REGISTRATION OF MEMBERSHIP INTEREST. The  Member acknowledges
that the Membership Interest has not been registered under the Securities Act of
1933, as amended (the "Securities Act"), or qualified under the California
Corporate Securities Law of 1968, as amended, or any other applicable blue sky
laws in reliance, in part, on the Member's representations, warranties, and
agreements herein.

        14.8   MEMBERSHIP INTEREST IN RESTRICTED SECURITY. The Member

understands that the Membership Interest is a "restricted security" under the
Securities Act in that the Membership Interest will be acquired from the Company
in a transaction not involving a public offering, and that the Membership
Interest may be resold without registration under the Securities Act only in
certain limited circumstances and that otherwise the Membership Interest must be
held indefinitely. In this connection, the Member understands the resale
limitations imposed by the Securities Act and is familiar with SEC Rule 144, as
presently in effect, and the conditions which must be met in order for that Rule
to be available for resale of "restricted securities," including the requirement
that the securities must be held for at least two years after purchase thereof
from the Company prior to resale (three years in the absence of publicly
available information about the Company) and the condition that there be
available to the public current information about the Company under certain
circumstances. The Member understands that the Company has not made such
information available to the public and has no present plans to do so. 

        14.9   NO OBLIGATION TO REGISTER. The Member represents, warrants, and
agrees that the Company and the Managers are under no obligation to register or
qualify the Membership Interest under the Securities Act or under any state
securities law, or to assist the Member in complying with any exemption from
registration and qualification.



                                      -38-
<PAGE>   46

        14.10  NO DISPOSITION IN VIOLATION OF LAW. Without limiting the
representations set forth above, and without limiting Article IX of this
Agreement, the Member will not make any disposition of all or any part of the
Membership Interest which will result in the violation by the Member or by the
Company of the Securities Act, the California Corporate Securities Law of 1968,
or any other applicable securities laws. Without limiting the foregoing, the
Member agrees not to make any disposition of all or any part of the Membership
Interest unless and until the Member has notified the Company of the proposed
disposition and has furnished the Company with a detailed statement of the
circumstances surrounding the proposed disposition, and if reasonably requested
by the Manager, the Member has furnished the Company with a written opinion of
counsel, reasonably satisfactory to the Company, that such disposition will not
require registration of any securities under the Securities Act or the consent
of or a permit from appropriate authorities under any applicable state
securities law. 

        14.11  LEGENDS. The Member understands that the certificates evidencing 
the Membership Interest may bear the following legend:

      The Membership Interests represented by this Certificate may not be 
      sold, transferred or otherwise disposed of except in accordance with and
      subject to the restrictions, terms and conditions of the Operating
      Agreement of the Company, a copy of which is on deposit with the Managers
      of the Company. Furthermore, the securities represented by this
      Certificate have not been registered under the Securities Act of 1933 nor
      registered nor qualified under any state securities laws. Such securities
      may not be offered for sale, sold, delivered after sale, transferred,
      pledged, or hypothecated unless qualified and registered under applicable
      state and federal securities laws or unless, in the opinion of counsel
      satisfactory to the Company, such qualification and registration is not
      required.

        14.12  INVESTMENT RISK.  The Member acknowledges that the Membership 
Interest is a speculative investment which involves a substantial degree of risk
of loss by the Member of the Member's investment in the Company, that the Member
understands and takes full cognizance of the risk factors related to the
purchase of the Membership Interest, and that the Company is newly organized and
has no financial or operating history.
                
        14.13  RESTRICTIONS ON TRANSFERABILITY.  The Member acknowledges that 
there are substantial restrictions on the transferability of the Membership
Interest pursuant to this Agreement, that there is no public market for the
Membership Interest and none is expected to develop, and that, accordingly, it
may not be possible to liquidate the investment in the Company.

        14.14  INFORMATION REVIEWED.  The Member has received and reviewed all 
information the Member considers necessary or appropriate for deciding whether
to purchase the Membership Interest. The Member has had an opportunity to ask
questions and receive 




                                      -39-
<PAGE>   47

answers from the Company and its Managers regarding the terms and conditions of
purchase of the Membership Interest and regarding the business, financial
affairs, and other aspects of the Company and has further had the opportunity to
obtainall information (to the extent the Company possesses or can acquire such
information without unreasonable effort or expense) which the Member deems
necessary to evaluate the investment and to verify the accuracy of information
otherwise provided to such Member. 

        14.15 NO REPRESENTATIONS BY COMPANY. Neither the Managers nor any agent
or employee of the Company or of any Manager nor any other Person has at any
time expressly or implicitly represented, guaranteed, or warranted to the Member
that the Member may freely transfer the Membership Interest, that a percentage
of profit and/or amount or type of consideration will be realized as a result of
an investment in the Membership Interest, that past performance or experience on
the part of the Managers or their Affiliates or any other person in any way
indicates the predictable results of the ownership of the Membership Interest or
of the overall Company business, that any cash distributions from Company
operations or otherwise will be made to the Members by any specific date or will
be made at all, or that any specific tax benefits will accrue as a result of an
investment in the Company. Without limiting the generality of the foregoing, the
Member understands that any proforma distributed to the Members are estimates
only, and are not representations, guarantees or warranties of results.

        14.16 CONSULTATION WITH ATTORNEY. The Member has had an opportunity to
consult with the Member's own attorney regarding all legal matters concerning an
investment in the Company and the tax consequences of participating in the
Company, and has done so to the extent the Member considers necessary.

        14.17 TAX CONSEQUENCES. The Member acknowledges that the tax 
consequences of investing in the Company will depend on the Member's particular
circumstances, and neither the Company, the Manager, the other Members, nor the
partners, shareholders, members, managers, agents, officers, directors,
employees, Affiliates, or consultants of any of them will be responsible or
liable for the tax consequences to the Member of an investment in the Company.
The Member will look solely to, and rely upon, the Member's own advisers with
respect to the tax consequences of this investment.

        14.18 NO ASSURANCE OF TAX BENEFITS. The Member acknowledges that there 
can be no assurance that the Code or the Regulations will not be amended or
interpreted in the future in such a manner so as to deprive the Company and the
Members of some or all of the tax benefits they might now receive, nor that some
of the deductions claimed by the Company or the allocations of items of income,
gain, loss, deduction, or credit among the Members may not be challenged by the
Internal Revenue Service

        14.19 INDEMNITY. The Member shall indemnify and hold harmless the 
Company, the Manager, each and every other Member, and any officers, directors,
shareholders, managers,


                                      -40-
<PAGE>   48

members, employees, partners, agents, attorneys, registered representatives, and
control persons of any such entity who was or is a party or is threatened to be
made a party to any threatened, pending, or completed action, suit, or
proceeding, whether civil, criminal, administrative, or investigative, by reason
of or arising from any misrepresentation or misstatement of facts or omission to
represent or state facts made by such Member including, without limitation, the
information in this Agreement, against losses, liabilities, and expenses of the
Company, the Manager, each and every other Member, and any officers, directors,
shareholders, managers, members, employees, partners, attorneys, accountants,
agents, registered representatives, and control persons of any such Person
(including attorneys' fees, judgments, fines, and amounts paid in settlement,
payable as incurred) incurred by such Person in connection with such action,
suit, proceeding, or the like. 

        14.20  REPRESENTATIONS BY NEXUS. Nexus warrants and represents (each of
which warranty and representation shall be deemed to be a continuing warranty
and representation and a covenant that such warranty and representation shall
remain true and correct at all times during the term of this Agreement):

               14.20.1  STATUS. Nexus is a California corporation duly formed 
and organized, validly existing and in good standing under the laws of the State
of California and has the power and adequate authority to execute, deliver and
perform this Agreement, which upon such execution and delivery will be a valid
and binding obligation enforceable in accordance with its terms (subject only to
the application of bankruptcy, insolvency or other similar laws regarding the
rights of creditors generally and the exercise of judicial discretion in
equity).

               14.20.2  DUE AUTHORIZATION.  The execution, delivery and 
performance of this Agreement by Nexus is duly authorized by all requisite
action of Nexus as of the date hereof, do not require the consent or approval of
any person that has not been obtained, and are not in contravention of or in
conflict with any term or provision of the articles of incorporation, bylaws and
charter documents of Nexus.

               14.20.3  OTHER AGREEMENTS. The execution, delivery and 
performance of this Agreement will not breach or constitute a default under any
agreement, indenture, undertaking or other instrument to which Nexus or any
Affiliate of Nexus is a party or by which any of such persons or any of their
respective properties may be bound or affected, which breach or default would
have a materially adverse effect on the financial condition, properties or
operations of this Company, and other than as contemplated by this Agreement,
such execution, delivery and performance will not result in the creation or
imposition of (or the obligation to create or impose) any lien or encumbrance on
any of the Company property.

        14.21  REPRESENTATIONS OF NEUROCRINE.   Neurocrine warrants and 
represents (each of which warranty and representation shall be deemed to be a
continuing warranty and representation and a covenant that such warranty and
representation shall remain true and correct at all times during the term of
this Agreement):
                  




                                      -41-
<PAGE>   49

               14.21.1   STATUS. Neurocrine is a Delaware corporation duly 
formed and organized, validly existing and in good standing under the laws of
the State of Delaware and has the power and adequate authority to execute,
deliver and perform this Agreement, which upon such execution and delivery will
be a valid and binding obligation enforceable in accordance with its terms
(subject only to the application of bankruptcy, insolvency or other similar laws
regarding the rights of creditors generally and the exercise of judicial
discretion in equity).

               14.21.2   DUE AUTHORIZATION.  The execution, delivery and 
performance of this Agreement by Neurocrine is duly authorized by all requisite
action of Neurocrine as of the date hereof, do not require the consent or
approval of any person that has not been obtained, and are not in contravention
of or in conflict with any term or provision of the articles of incorporation,
bylaws and charter documents of Neurocrine.


               14.21.3   OTHER AGREEMENTS. The execution, delivery and 
performance of this Agreement will not breach or constitute a default under any
agreement, indenture, undertaking or other instrument to which Neurocrine or any
Affiliate of Neurocrine is a party or by which any of such persons or any of
their respective properties may be bound or affected, which breach or default
would have a materially adverse effect on the financial condition, properties or
operations of this Company, and other than as contemplated by this Agreement,
such execution, delivery and performance will not result in the creation or
imposition of (or the obligation to create or impose) any lien or encumbrance on
any of the Company property.

                                   ARTICLE XV
                                 MISCELLANEOUS


        15.1  REPRESENTATION BY COUNSEL. Counsel to the Company may also be
counsel to a Member or Manager of the Company. The Company has initially
selected Sullivan Wertz McDade & Wallace ("Company Counsel") as legal counsel to
the Company, to organize the Company, to represent the Company in the
development, leasing, financing, construction and sale of the Property, and to
provide such other legal services as the Company may request. Company Counsel
also represented Nexus in the preparation and negotiation of this Agreement, and
has represented, and will continue to represent, the Nexus and its Affiliates
with regard to real estate development and other activities both related and
unrelated to the Company. This representation involves potential conflicts of
interest in that the interests and objectives of Nexus may be or become
inconsistent with the interests and objectives of the Company or Neurocrine or
other Members. By signing this Agreement, the Members waive any conflicts of
interest in regard thereto.

        15.2  BINDING EFFECT.  Subject to the provisions of this Agreement 
relating to transferability, this Agreement will be binding upon and inure to
the benefit of the Members, and their respective successors and assigns.



                                      -42-
<PAGE>   50

        15.3 PARTIES IN INTEREST. Except as expressly provided in the Act, 
nothing in this Agreement shall confer any rights or remedies under or by reason
of this Agreement on any Persons other than the Members and the Managers and
their respective successors and assigns nor shall anything in this Agreement
relieve or discharge the obligation or liability of any third person to any
party to this Agreement, nor shall any provision give any third person any right
of subrogation or action over or against any party to this Agreement. 

        15.4 PRONOUNS: STATUTORY REFERENCES. All pronouns and all variations
thereof shall be deemed to refer to the masculine, feminine, or neuter, singular
or plural, as the context in which they are used may require. Any reference to
the Code, the Regulations, the Act, Corporations Code or other statutes or laws
will include all amendments, modifications, or replacements of the specific
sections and provisions concerned.

        15.5 HEADINGS. All headings herein are inserted only for convenience and
ease of reference and are not to be considered in the construction or
interpretation of any provision of this Agreement.

        15.6 INTERPRETATION. In the event any claim is made by any Member 
relating to any conflict, omission or ambiguity in this Agreement, no
presumption or burden of proof or persuasion shall be implied by virtue of the
fact that this Agreement was prepared by or at the request of a particular
Member or such Member's counsel.

        15.7 REFERENCES TO THIS AGREEMENT. Numbered or lettered articles, 
sections and subsections herein contained refer to articles, sections and
subsections of this Agreement unless otherwise expressly stated.

        15.8 GOVERNING LAW/JURISDICTION/VENUE. This Agreement shall be construed
in accordance with California law, and any arbitrator appointed hereunder shall
be required to apply such law. Each Member hereby consents to the exclusive
jurisdiction of the Superior Court of the State of California, County of San
Diego, on a claim arising out of, under or in connection with this Agreement or
the transactions contemplated by this Agreement, provided such claim is not
required to be arbitrated pursuant to Section 15.10.

        15.9 ARBITRATION. Any dispute arising from or related to this Agreement,
the Company or the Premises shall be resolved by binding arbitration under the
Commercial Rules of the American Arbitration Association, and venue for any such
arbitration shall be the County of San Diego.

        15.10 SEVERABILITY. If any provision of this Agreement or the 
application of such provision to any person or circumstance shall be held
invalid, the remainder of this Agreement or the application of such provision to
persons or circumstances other than those to which it is held invalid shall not
be affected thereby.


                                      -43-
<PAGE>   51

        15.11 ADDITIONAL DOCUMENTS AND ACTS. Each Member agrees to execute and
deliver such additional documents and instruments and to perform such additional
acts as may be necessary or appropriate to effectuate, carry out and perform all
of the terms, provisions, and conditions of this Agreement and the transactions
contemplated hereby.

        15.12 NOTICES. Any notice to be given or to be served upon the Company
or any party hereto in connection with this Agreement must be in writing (which
may include facsimile) and will be deemed to have been given and received when
delivered to the address specified by the party to receive the notice. Such
notices will be given to a Member or Manager at the last known business or
residence address of the Member or the Manager. Any party may, at any time by
giving five days' prior written notice to the other parties, designate any other
address in substitution of the foregoing address to which such notice will be
given.

        15.13 AMENDMENTS. The consent of Members who are not the subject of a
Dissolution Event holding at least two-thirds of the Membership Interests shall
be required to amend this Agreement or the Articles. All amendments to this
Agreement or the Articles will be in writing and signed by all of the Members
whose consent is required.

        15.14 RELIANCE ON AUTHORITY OF PERSON SIGNING AGREEMENT. If a Member is
not a natural person, neither the Company nor any Member will (a) be required to
determine the authority of the individual signing this Agreement to make any
commitment or undertaking on behalf of such entity or to determine any fact or
circumstance bearing upon the existence of the authority of such individual or
(b) be responsible for the application or distribution of proceeds paid or
credited to individuals signing this Agreement on behalf of such entity.

        15.15 NO INTEREST IN COMPANY PROPERTY: WAIVER OF ACTION FOR PARTITION.
No Member or Economic Interest Owner has any interest in specific property of
the Company. Without limiting the foregoing, each Member and Economic Interest
Owner irrevocably waives during the term of the Company any right that the
Member may have to maintain any action for partition with respect to the
property of the Company.

        15.16 MULTIPLE COUNTERPARTS. This Agreement may be executed in two or 
more counterparts, each of which shall be deemed an original, but all of which
shall constitute one and the same instrument. 

        15.17 ATTORNEY FEES. In the event that any dispute between the Company 
and the Members or among the Members should result in litigation or arbitration,
the prevailing party in such dispute shall be entitled to recover from the other
party all reasonable fees, costs and expenses of enforcing any right of the
prevailing party, including, without limitation, reasonable attorneys' fees and
expenses.


                                      -44-
<PAGE>   52

        15.18 TIME IS OF THE ESSENCE. All dates and times in this Agreement are
of the essence.

        15.19 REMEDIES CUMULATIVE. The remedies under this Agreement are
cumulative and shall not exclude any other remedies to which any person may be
lawfully entitled. 

        15.20 NEUROCRINE DEFAULT. A ?Neurocrine Default? shall mean all of the
following have occurred: (i) there has been a continuous default in the payment
of Rent by Neurocrine under the Neurocrine Lease for a period of ninety (90)
days, and (ii) the Neurocrine Lease has been terminated in accordance with
Section 24.5 of the Neurocrine Lease prior to Neurocrine?s cure of the default
in the payment of Rent. In the event of a Neurocrine Default, the Deed of Trust
securing the Neurocrine Loan shall be released and reconveyed from the Premises
by the written request of Nexus to the Trustee under such Deed of Trust. Any
such release shall not affect any amounts due from the Company to Neurocrine
under the Promissory Note given for the Neurocrine Loan. In addition,
notwithstanding any other provision of this Agreement, if Neurocrine has been in
continuous default in the payment of Rent under the Neurocrine Lease for a
period of ninety (90) days, Neurocrine shall become an Economic Interest Owner
rather than a Member under this Agreement unless and until the default is cured,
although this Agreement may not thereafter be amended without the consent of
Neurocrine in a manner which would increase its obligations or liabilities.

        IN WITNESS WHEREOF, the Members of Science Park Center LLC, a California
limited liability company, have executed this Agreement, effective as of the
date written above.

NEUROCRINE BIOSCIENCES, INC.
a Delaware Corporation

By: /s/ PAUL W. HAWRAN
   ---------------------------------

NEXUS PROPERTIES, INC.
a California Corporation


By: /s/ MICHAEL J. REIDY
   ---------------------------------
        Michael J. Reidy
        Chief Executive Officer

/s/ BRANDON CROCKER
- ------------------------------------
BRANDON CROCKER

                                      -45-
<PAGE>   53





                                   SCHEDULE 1

                                 PROJECT BUDGET


                                      -46-
<PAGE>   54
                                   NEUROCRINE
                              *** SF R&D FACILITY
                           PRELIMINARY COST PRO FORMA
                                      ***

<TABLE>
<S>                                                  <C>            <C>

                                      ***
</TABLE>
 
* confidential treatment
<PAGE>   55
                                   SCHEDULE 2

                      ESTIMATED CASH DISTRIBUTION SCHEDULE


















                                      -47-
<PAGE>   56
                                   SCHEDULE 2

                                  Page 1 of 2



                                   NEUROCRINE

                               CASH FLOW SCHEDULE

                                      ***




* confidential treatment


 
<PAGE>   57
                                   SCHEDULE 2

                                  Page 2 of 2



                                   NEUROCRINE

                               CASH FLOW SCHEDULE

***

* confidential treatment
<PAGE>   58

                                   SCHEDULE 3

                         ESTIMATED OPTION PURCHASE PRICE

















                                      -48-
<PAGE>   59

                                   SCHEDULE 3


                                   NEUROCRINE

                            OPTION PRICE CALCULATION



***


* confidential treatment

<TABLE> <S> <C>

<ARTICLE> 5
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          DEC-31-1997
<PERIOD-START>                             JUL-01-1997
<PERIOD-END>                               SEP-30-1997
<CASH>                                      15,094,554
<SECURITIES>                                53,832,352
<RECEIVABLES>                                2,631,488
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                                     0
<PP&E>                                       5,340,892
<DEPRECIATION>                                       0
<TOTAL-ASSETS>                              84,905,832
<CURRENT-LIABILITIES>                        5,271,682
<BONDS>                                              0
                                0
                                          0
<COMMON>                                    83,496,706
<OTHER-SE>                                           0
<TOTAL-LIABILITY-AND-EQUITY>                84,905,832
<SALES>                                              0
<TOTAL-REVENUES>                             6,240,779
<CGS>                                                0
<TOTAL-COSTS>                                6,564,414
<OTHER-EXPENSES>                             (257,380)
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                              35,088
<INCOME-PRETAX>                                957,672
<INCOME-TAX>                                   145,161
<INCOME-CONTINUING>                                  0
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   812,511
<EPS-PRIMARY>                                      .04
<EPS-DILUTED>                                      .04
        

</TABLE>


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