NEUROCRINE BIOSCIENCES INC
DEF 14A, 2000-04-27
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                            SCHEDULE 14A INFORMATION

Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934

Filed by the Registrant  [ X ]
Filed by a Party other than the Registrant  [    ]

Check the appropriate box:

[     ]  Preliminary Proxy Statement
[     ]  Confidential, for Use of the Commission Only
[ X ]    Definitive Proxy Statement
[     ]  Definitive Additional Materials
[     ]  Soliciting Material Pursuant toss.240.14a-11(c) orss.240.14a-12

Neurocrine Biosciences, Inc.
(Name of Registrant as specified in its charter)


(Name of Person(s) Filing Proxy Statement, if other than the Registrant)

Payment of Filing Fee (Check the appropriate box):
[  X  ]  No filing fee.
[     ]  $125 per Exchange Act Rules 0-11(c)(1)(ii), 14a-6(i)(1) or 14a-6(i)(2).
[     ]  $500 per each party to the controversy pursuant to Exchange Act Rule
         14a-6(i)(3).
[     ]  Fee computed on table below per Exchange Act Rules 14a-6(i)(4)and 0-11.

     (1)  Title of each class of securities to which transaction applies:

     (2)  Aggregate number of securities to which transaction applies:

     (3)  Per unit  price  or other  underlying  value of  transaction  computed
          pursuant to Exchange  Act Rule 0-11 (Set forth the amount on which the
          filing fee is calculated and state how it was determined.):

     (4)  Proposed maximum aggregate value of transaction:

     (5)  Total fee paid:


[     ]  Fee paid previously with preliminary materials.
[     ]  Check box if any  part of the fee is offset as  provided  by  Exchange
         Act Rule  0-11(a)(2)  and identify the filing for which the  offsetting
         fee was paid  previously.  Identify the previous filing by registration
         statement number, or the Form or Schedule and the date of its filing.

     (1)  Amount Previously Paid:

     (2)  Form, Schedule or Registration Statement No.:

     (3)  Filing Party:

     (4)  Date Filed:



<PAGE>



                          NEUROCRINE BIOSCIENCES, INC.
                             -------------------

                    Notice of Annual Meeting of Stockholders
                           To Be Held on May 24, 2000


 TO THE STOCKHOLDERS:

      NOTICE IS HEREBY  GIVEN that the 2000 Annual  Meeting of  Stockholders  of
 Neurocrine Biosciences,  Inc., a Delaware corporation (the "Company"),  will be
 held on May 24,  2000,  at 8:30 a.m.  local time,  at the  Company's  corporate
 headquarters,  located at 10555 Science  Center Drive,  San Diego,  California,
 92121 for the following purposes as more fully described in the Proxy Statement
 accompanying this Notice:

1.   To elect two Class I  Directors  to the Board of  Directors  to serve for a
     term of three years.

2.   To amend the Company's 1992 Incentive  Stock Plan to increase the number of
     shares of Common Stock  reserved for issuance  from  5,300,000 to 6,050,000
     shares.

3.   To amend the Company's  1996 Employee  Stock  Purchase Plan to increase the
     number of shares of Common  Stock  reserved  for  issuance  from 125,000 to
     425,000 shares.

4.   To amend the  Company's  1996  Director  Stock  Option Plan to increase the
     number of shares of Common  Stock  reserved  for  issuance  from 200,000 to
     300,000 shares.

5.   To ratify the appointment of Ernst & Young LLP as the Company's independent
     public accountants for the fiscal year ending December 31, 2000.

6.   To transact such other  business as may properly come before the meeting or
     any adjournment thereof.

      Only  stockholders of record at the close of business on April 7, 2000 are
 entitled to receive notice and to vote at the meeting.

      All  stockholders  are cordially  invited to attend the meeting in person.
 However, to assure your  representation at the meeting,  you are urged to mark,
 sign,  date and return the  enclosed  Proxy card as promptly as possible in the
 prepaid-postage envelope enclosed for that purpose.  Stockholders attending the
 meeting may vote in person even if they have returned a Proxy.


                                             By Order of the
                                             Board of Directors,

                                             Margaret Valeur-Jensen
                                             Secretary

San Diego, California
April 27, 2000

<PAGE>




                          NEUROCRINE BIOSCIENCES, INC.

                                 PROXY STATEMENT

                 INFORMATION CONCERNING SOLICITATION AND VOTING

GENERAL

         The enclosed  Proxy is solicited on behalf of  Neurocrine  Biosciences,
Inc., a Delaware corporation (the "Company"), for use at its 2000 Annual Meeting
of Stockholders to be held on May 24, 2000, at 8:30 a.m.,  local time, or at any
adjournments or postponements  thereof, for the purposes set forth in this Proxy
Statement and in the accompanying Notice of Annual Meeting of Stockholders.  The
Annual Meeting will be held at the Company's corporate headquarters,  located at
10555 Science Center Drive, San Diego, California 92121. The Company's telephone
number is (858) 658-7600.

         These proxy solicitation  materials were mailed on or about May 2, 2000
to all stockholders entitled to vote at the meeting.

RECORD DATE; OUTSTANDING SHARES

         Stockholders  of record at the close of  business on April 7, 2000 (the
"Record Date") are entitled to receive notice of and vote at the meeting. On the
record date,  21,853,303 shares of the Company's Common Stock, $0.001 par value,
were issued and outstanding.  The Company has approximately  6,400 shareholders,
of which approximately 160 are shareholders of record. For information regarding
holders of more than five percent of the  outstanding  Common Stock,  see "Stock
Ownership of Principal Stockholders and Management" below.

REVOCABILITY OF PROXIES

         Proxies given pursuant to this  solicitation may be revoked at any time
before they have been used. Revocation will occur by delivering a written notice
of revocation to the Company or by duly  executing a proxy bearing a later date.
Revocation  will also  occur if the  person  attends  the  meeting  and votes in
person.

VOTING AND SOLICITATION

         Every  stockholder  of record on the Record Date is entitled,  for each
share held,  to one vote on each proposal or item that comes before the meeting.
In the election of Directors,  each stockholder will be entitled to vote for two
nominees and the two nominees with the greatest number of votes will be elected.

         The cost of this solicitation will be borne by the Company. The Company
may  reimburse   expenses   incurred  by  brokerage   firms  and  other  persons
representing  beneficial owners of shares in forwarding solicitation material to
beneficial  owners.  Proxies  may be  solicited  by  certain  of  the  Company's
Directors,  officers and regular  employees,  without  additional  compensation,
personally, by telephone or by telegram.

QUORUM; ABSTENTIONS; BROKER NON-VOTES

         Votes  cast  by  proxy  or in  person  at the  Annual  Meeting  will be
tabulated by the Inspector of Elections (the "Inspector") with the assistance of
the Company's Transfer Agent. The Inspector will also determine whether or not a
quorum is present.  Except in certain  specific  circumstances,  the affirmative
vote of a majority of shares present in person or represented by proxy at a duly
held  meeting at which a quorum is present is required  under  Delaware  law for

<PAGE>

approval of proposals presented to stockholders.  In general,  Delaware law also
provides  that a quorum  consists of a majority  of shares  entitled to vote and
present or represented by proxy at the meeting.

         The Inspector will treat shares that are voted  "WITHHELD" or "ABSTAIN"
as being present and entitled to vote for purposes of  determining  the presence
of a quorum but will not be treated  as votes in favor of  approving  any matter
submitted to the  stockholders for a vote. Any proxy which is returned using the
form of proxy  enclosed and which is not marked as to a particular  item will be
voted for the election of the Directors named in the proxy,  for the approval of
the  amendment  of the  1992  Incentive  Stock  Plan,  for the  approval  of the
amendment of the 1996  Employee  Stock  Purchase  Plan,  for the approval of the
amendment to the 1996 Directors  Stock Option Plan, for the  confirmation of the
appointment  of the  designated  independent  auditors and, as the proxy holders
deem advisable,  on other matters that may come before the meeting,  as the case
may be with respect to the items not marked.

         If a broker  indicates on the enclosed proxy or its substitute  that it
does  not  have  discretionary  authority  as to  certain  shares  to  vote on a
particular  matter  ("Broker  Non-Votes"),  those shares will be  considered  as
present with respect to that matter.  The Company  believes that the  tabulation
procedures  to be  followed by the  Inspector  are  consistent  with the general
statutory requirements in Delaware concerning voting of shares and determination
of a quorum.

DEADLINE FOR RECEIPT OF STOCKHOLDER PROPOSALS

         Stockholder  proposals  which  are  intended  to be  presented  at  the
Company's  2001  Annual  Meeting  must be  received by the Company no later than
December 29, 2000 in order that they may be included in the proxy  statement and
form of proxy for that meeting.

SECTION 16(A) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE

         Section 16(a) of the Securities Exchange Act of 1934, as amended,  (the
"Exchange Act") requires the Company's  officers and Directors,  and persons who
own  more  than ten  percent  of a  registered  class  of the  Company's  equity
securities,  to file  reports of ownership on Form 3 and changes in ownership on
Form 4 or Form 5 with the SEC. Such officers, Directors and 10% stockholders are
also  required by SEC rules to furnish  the  Company  with copies of all Section
16(a)  forms they file.  Based  solely on its review of the copies of such forms
received by it, or written  representations  from certain reporting persons, the
Company  believes  that,  during the fiscal year ended  December 31,  1999,  all
Section 16(a) filing requirements applicable to its officers,  Directors and 10%
stockholders were complied with.

STOCK OWNERSHIP OF PRINCIPAL STOCKHOLDERS AND MANAGEMENT

         The  following  table  sets  forth  the  beneficial  ownership  of  the
Company's Common Stock as of April 7, 2000 by (i) each of the executive officers
named  in the  table  under  "Compensation  of  Executive  Officers  --  Summary
Compensation  Table," (ii) each  Director,  (iii) all  Directors  and  executive
officers  as a group  and  (iv)  all  persons  known  to the  Company  to be the
beneficial  owners of more than 5% of the  Company's  Common  Stock.  A total of
21,853,303  shares of the Company's  Common Stock were issued and outstanding as
of April 7, 2000.

<PAGE>
                                                   Shares
                                             Beneficially
Name and Address of Beneficial Owner (1)        Owned (2)           Percent
- - - - ----------------------------------------        ---------           -------

T. Rowe Price Associates
100 East Pratt Street
Baltimore, MD  21202 .....................      1,687,800             7.72%

D. Bruce Campbell (3).....................         92,089                 *

Paul W. Hawran (4)........................        349,532             1.60%

Gary A. Lyons (5).........................        909,039             4.16%

Margaret E. Valeur-Jensen (6).............         49,225                 *

Joseph A. Mollica (7).....................         32,080                 *

Richard F. Pops (8).......................         10,277                 *

Stephen A. Sherwin (9)....................          6,111                 *

Wylie W. Vale (10)........................        434,502             1.99%

All executive officers and
  Directors as a group (8 persons) (11)....     1,882,855             8.62%
- - - - ----------

*    Represents  beneficial  ownership  of less  than  one  percent  (1%) of the
     21,853,282  outstanding shares of the Company's Common Stock as of April 7,
     2000.

(1)  The address of each individual named is c/o Neurocrine  Biosciences,  Inc.,
     10555  Science  Center  Drive,  San  Diego,  CA  92121,   unless  otherwise
     indicated.

(2)  Beneficial  ownership is  determined  in  accordance  with the rules of the
     Securities  and  Exchange  Commission  and  generally  includes  voting  or
     investment power with respect to securities. Shares of Common Stock subject
     to stock options and warrants  currently  exercisable or exercisable within
     60 days of April 7, 2000 are deemed to be  outstanding  for  computing  the
     percentage  ownership of the person holding such options and the percentage
     ownership of any group of which the holder is a member,  but are not deemed
     outstanding  for  computing the  percentage of any other person.  Except as
     indicated  by  footnote,  and  subject  to  community  property  laws where
     applicable,  the persons named in the table have sole voting and investment
     power with respect to all shares of Common Stock shown  beneficially  owned
     by  them.

(3)  Includes 92,089 shares issuable pursuant to options  exercisable  within 60
     days of April 7, 2000.

(4)  Includes 227,734 shares issuable pursuant to options  exercisable within 60
     days of April 7, 2000.

(5)  Includes 489,183 shares issuable pursuant to options  exercisable within 60
     days of April 7, 2000.

(6)  Includes 44,907 shares issuable pursuant to options  exercisable  within 60
     days of April 7, 2000.

(7)  Includes 32,080 shares issuable pursuant to options  exercisable  within 60
     days of April 7, 2000.

(8)  Includes 10,277 shares issuable pursuant to options  exercisable  within 60
     days of April 7, 2000.

(9)  Includes 6,111 shares issuable  pursuant to options  exercisable  within 60
     days of April 7, 2000.

(10) Includes 125,372 shares issuable pursuant to options  exercisable within 60
     days of April 7, 2000.

(11) Includes an  aggregate  of 1,027,753  shares  issuable  pursuant to options
     exercisable within 60 days of April 7, 2000.


<PAGE>


                                  PROPOSAL ONE:

                              ELECTION OF DIRECTORS

GENERAL

         The Company's Bylaws provide that the Board of Directors is composed of
seven (7) Directors.  The Company's  Certificate of Incorporation  provides that
the Board of Directors is divided into three  classes.  As of December 31, 1999,
there were two Directors in Class I (Wylie W. Vale and Joseph A.  Mollica),  two
Directors in Class II (Stephen A. Sherwin and Richard F. Pops), and one Director
in Class III (Gary A. Lyons).  David E.  Robinson was a Class II Director  until
his  resignation  from the Board of Directors on March 2, 1999. This vacancy was
filled with the  appointment  of Stephen A. Sherwin on April 22, 1999.  Harry F.
Hixson,  Jr. resigned from the Board of Directors on December 31, 1999. There is
currently one (1) unfilled Class I  Directorship  and one (1) unfilled Class III
Directorship.

         The  Directors in Class I hold office until the 2000 Annual  Meeting of
Stockholders,  the  Directors  in Class II hold  office  until  the 2001  Annual
Meeting of  Stockholders  and the  Directors  in Class III hold office until the
2002  Annual  Meeting of  Stockholders  (or, in each case,  until their  earlier
resignation,  removal  from  office or  death).  After each such  election,  the
Directors in each such case will then serve in  succeeding  terms of three years
and until  their  successors  are duly  elected and  qualified.  Officers of the
Company serve at the  discretion of the Board of Directors.  There are no family
relationships among the Company's Directors and executive officers.

         The term of office of  Directors  Wylie W. Vale and  Joseph A.  Mollica
expire at the 2000 Annual Meeting. At the 2000 Annual Meeting,  the stockholders
will elect two Class I Directors for a term of three years.

VOTE REQUIRED

         The two nominees  receiving the highest number of affirmative  votes of
the shares  present in person or  represented by proxy at the Annual Meeting and
entitled to vote on the election of  Directors  shall be elected to the Board of
Directors.

         Votes   withheld   from  any  Director  are  counted  for  purposes  of
determining the presence or absence of a quorum,  but have no legal effect under
Delaware law.  While there is no  definitive  statutory or case law authority in
Delaware as to the proper  treatment of abstentions and broker  non-votes in the
election of Directors,  the Company  believes that both  abstentions  and broker
non-votes  should be counted for  purposes of whether a quorum is present at the
Annual Meeting. In the absence of precedent to the contrary, the Company intends
to treat  abstentions  and broker  non-votes  with  respect to the  election  of
Directors in this manner.

         Unless  otherwise  instructed,  the proxy holders will vote the proxies
received by them for the Company's two nominees  named below.  If any nominee of
the  Company is unable or  declines  to serve as a  Director  at the time of the
Annual  Meeting,  the proxies will be voted for any nominee who is designated by
the present Board of Directors to fill the vacancy.  It is not expected that any
nominee  will be unable or will  decline  to serve as a  Director.  The Board of
Directors recommends that stockholders vote "FOR" the nominees listed below.

<PAGE>

NOMINEES FOR ELECTION AT THE ANNUAL MEETING

         Both of the  nominees  (Wylie  W.  Vale and  Joseph  A.  Mollica.)  are
presently  Class I  Directors  of the  Company.  Certain  information  about the
nominees is set forth below: Director

Name                         Age   Position in the Company       Since
- - - - ----                         ---   -----------------------       -----
Joseph A. Mollica (1) (2)    59    Chairman of the Board          1997

Wylie W. Vale.............   57    Chief Scientific Advisor,      1992
                                    Neuroendocrinology
                                    and Director
- - - - ----------
(1)      Member of the Audit Committee.
(2)      Member of the Compensation Committee.

         Joseph A. Mollica, Ph.D., has served as a Director of the Company since
June 1997 and became Chairman of the Board in April 1998. He currently serves as
the Chairman of the Board of Directors, President and Chief Executive Officer of
Pharmacopeia,  Inc.,  a  biopharmaceutical  company  focusing  on  combinatorial
chemistry,  high through-put  discovery,  molecular modeling and bioinformatics,
since  February  1994.  From 1987 to December  1993, Dr. Mollica was employed by
DuPont Company and then by the DuPont Merck  Pharmaceutical  Company where, from
1991 to 1993, he served as President and CEO and  previously as Vice  President,
Medical Products for DuPont.  At Ciba-Geigy,  where he was employed from 1966 to
1986, he served in a variety of positions of increasing responsibility rising to
Senior Vice President of Ciba-Geigy's  Pharmaceutical  Division. He is currently
on the Boards of Ancile  Pharmaceuticals,  Biotechnology  Council of New Jersey,
Biotechnology Industry Organization,  Impath, Inc. and Nexell Therapeutics, Inc.
He received his B.S. from the  University of Rhode Island and his M.S. and Ph.D.
from the University of Wisconsin.

         Wylie W. Vale,  Ph.D., is a Founder and Chairman of the Company's Board
of  Scientific  and  Medical  Advisors.  Dr.  Vale was elected a Director of the
Company in September  1992. He is a Professor and former Chairman of the Faculty
at The Salk Institute for Biological  Studies ("The Salk  Institute") and is the
Senior Investigator and Head of The Clayton Foundation  Laboratories for Peptide
Biology at The Salk  Institute,  where he has been employed for 29 years.  He is
also an Adjunct  Professor of Medicine at the  University  of  California at San
Diego. Dr. Vale is recognized for his work on the molecular, pharmacological and
biomedical  characterization of neuroendocrine  factors including  somatostatin,
growth hormone releasing factor,  gonadotropin releasing hormone activin and the
activin  receptor (the first receptor  serine kinase),  corticotropin  releasing
factor,  CRF-binding protein, the CRF1 receptor and urocortin, the native ligand
for the CRF2  receptor.  In  recognition  of his  discoveries,  he has  received
numerous awards and is a member of the National Academy of Arts and Sciences and
the  National  Academy  of  Sciences.  He is a past  President  of the  American
Endocrine Society and is the current  President of the International  Society of
Endocrinology.  Dr. Vale received a B.A. in Biology from Rice University,  and a
Ph.D. in Physiology and Biochemistry from the Baylor College of Medicine.

INCUMBENT DIRECTORS WHOSE TERMS OF OFFICE CONTINUE AFTER THE ANNUAL MEETING

     The Class II and III Directors  will remain in office after the 2000 Annual
Meeting.  The Class II Directors are Richard F. Pops and Stephen A. Sherwin. The
Class  III  Director  is  Gary  Lyons.  The  names  and  certain  other  current
information  about the Directors whose terms of office continue after the Annual
Meeting  are set  forth  below:
                                                                   Director
Name of Director            Age  Position/Principal Occupation      Since
- - - - ----------------            ---  -----------------------------     ------
Gary A. Lyons.............. 49   President, Chief Executive         1992
                                  Officer and Director
Richard F. Pops (1) ....... 38   Director                           1998

Stephen A. Sherwin (2)..... 51   Director                           1999
- - - - ----------
(1)      Member of the Audit Committee.
(2)      Member of the Compensation Committee.

<PAGE>

     Gary A.  Lyons has  served as  President,  Chief  Executive  Officer  and a
Director of the Company  since  joining the Company in February  1993.  Prior to
joining the Company,  Mr. Lyons held a number of senior management  positions at
Genentech including Vice President of Business Development and Vice President of
Sales.  At  Genentech,   he  was  responsible   for   international   licensing,
acquisitions and partnering.  He was also responsible for Genentech's  Corporate
Venture  Program,  which  participated in early financing  and/or formation of a
number  of  biotechnology  companies.  In  addition,  Mr.  Lyons  had  operating
responsibility  for Genentech's two  subsidiaries,  Genentech  Canada,  Inc. and
Genentech  Limited (Japan).  Previously he served as Vice President of Sales and
was  responsible  for  building the  marketing  and sales  organization  for the
commercial  introduction  of  Genentech's  first  two  pharmaceutical  products,
Protropin  (human growth hormone) and Activase (TPA). Mr. Lyons currently serves
on the Board of Directors for Intrabiotics Pharmaceuticals, Inc. and Vical, Inc.
Mr. Lyons holds a B.S. in Marine  Biology from the  University  of New Hampshire
and an M.B.A.  from  Northwestern  University's  J.L. Kellogg Graduate School of
Management.

     Stephen A.  Sherwin,  M.D.,  was elected to the Board of Directors on April
22, 1999 as a Class II  Director.  Since March 1990,  Dr.  Sherwin has served as
Chief Executive Officer and Director of Cell Genesys, Inc. ("Cell Genesys").  In
March 1994, he was elected as Chairman of the Board of Cell  Genesys.  From 1983
to 1990, Dr. Sherwin held various positions at Genentech,  Inc., a biotechnology
company,  most recently as Vice President of Clinical  Research.  Prior to 1983,
Dr.  Sherwin  held  various  positions  on  the  staff  of the  National  Cancer
Institute.  Dr.  Sherwin  also  serves as a Director  of  Abgenix,  Inc.,  Calyx
Therapeutic, Inc. and Rigel Pharmaceuticals,  Inc. Dr. Sherwin holds a B.A. from
Yale and an M.D. from Harvard Medical School.

     Richard F. Pops became a Director of the Company in April 1998. Since 1991,
he has served as Chief  Executive  Officer of  Alkermes,  Inc.  ("Alkermes"),  a
publicly  traded company  involved in the  development of advanced drug delivery
systems.  Mr.  Pops  currently  serves on the board of  directors  of  Alkermes,
ImmuLogic  Pharmaceutical Corp., the Biotechnology Industry Organization and The
Brain Tumor Society. He is President of the Massachusetts Biotechnology Council.
He received a B.A. degree in Economics from Stanford University in 1983.

BOARD MEETINGS AND COMMITTEES

         The Board of  Directors  of the Company  held a total of 5 meetings and
took action by written  consent on 4 occasions  during 1999.  During  1999,  the
Board of Directors  had an Audit  Committee  and a  Compensation  Committee.  No
Director  attended  fewer  than 80% of the  aggregate  of the  total  number  of
meetings of the Board of Directors  and the total number of meetings held by all
committees of the Board of Directors on which he served.

     The Audit Committee in 1999 consisted of Directors  Richard F. Pops,  Harry
F.  Hixson,  Jr. and Wylie W. Vale and met once during 1999.  This  committee is
primarily  responsible  for  approving  the services  performed by the Company's
independent  auditors and for reviewing and evaluating the Company's  accounting
principles and its system of internal accounting controls.

     The  Compensation  Committee  in 1999  consisted  of  Directors  Joseph  A.
Mollica,  David E.  Robinson  until his  resignation,  Harry F. Hixson,  Jr. and
Stephen A. Sherwin  following his  appointment in April 1999. This committee met
four times and took action by written consent once during 1999. The Compensation
Committee  reviewed and  recommended to the Board the  compensation of executive
officers and other employees of the Company.

<PAGE>

BOARD COMPENSATION

         Non-employee   Directors  are  reimbursed  for  expenses   incurred  in
connection with performing their respective  duties as Directors of the Company.
The  Company did not pay cash  compensation  to any  Director  prior to February
1997. Directors,  who are not employees or consultants of the Company, receive a
$10,000  annual  retainer,  $1,000  for each  regular  meeting  of the  Board of
Directors  and $750 for each special  meeting,  committee  meeting and telephone
meeting lasting more than one hour, which such Director attends.  In addition to
the cash  compensation  set forth  above,  the Company has agreed to provide Dr.
Mollica, as Chairman of the Board, an additional annual retainer of $5,000.

         Each  non-employee  Director  participates  in the 1996 Director  Stock
Option Plan (the "Director  Plan").  Options granted under the Director Plan are
automatic and  non-discretionary and have a term of ten years. The Director Plan
provides for the grant of nonstatutory  options to purchase 12,000 shares of the
Company's Common Stock to each non-employee  Director (Dr. Mollica,  as Chairman
of the  Board,  will  receive  15,000  options)  at each  annual  meeting of the
stockholders  commencing in 1997,  provided that such non-employee  Director has
been a non-employee Director of the Company for at least six months prior to the
date of such annual meeting of the stockholders.  Each new non-employee Director
is automatically granted nonstatutory stock options to purchase 15,000 shares of
the  Company's  Common  Stock  upon the date  such  person  joins  the  Board of
Directors.

         All  options  granted  to  non-employee  Directors  shall vest over the
three-year  period  following the date of grant and shall be  exercisable at the
fair market value of the Company's Common Stock on the date of the grant.

         Effective  March 1, 2000,  each  non-employee  Director  is eligible to
participate  in the  Company's  Deferred  Compensation  Plan (the  "Compensation
Plan"). In addition to non-employee Directors of the Company, the Company's Vice
Presidents are eligible to participate in the Compensation Plan. Under the terms
of the Compensation Plan, each eligible  participant may elect to defer all or a
portion of cash  compensation  received for  services to the Company.  Elections
must be made by January 1 of each year (March 1 for  non-employee  Directors for
2000) and are irrevocable  once made. Upon receipt of an eligible  participant's
deferral  election,  the Company  maintains a deferred  compensation  investment
account  on  behalf  of  such  participant.   Funds  so  invested  are  paid  to
participants  upon death or 15 days  following the end of the month in which the
participant's  services  to the  Company  are  terminated.  Funds  may  also  be
withdrawn for hardship under some circumstances.  For the year 2000, Dr. Mollica
has elected to defer 100% of his cash  compensation from the Company pursuant to
the Compensation Plan.


                                  PROPOSAL TWO:

             APPROVAL OF AMENDMENT OF THE 1992 INCENTIVE STOCK PLAN

INCREASE OF 750,000 SHARES

         The Company's  1992  Incentive  Stock Plan, as amended (the "Plan") was
approved by the Board of Directors and the  stockholders of the Company in 1992.
Currently  there are a total of 5,300,000  shares of Common  Stock  reserved for
issuance  under the Plan.  In March  1999,  the Board of  Directors  approved  a
further  increase of 750,000 shares issuable under the Plan,  which, if approved
by the stockholders, would increase the total shares reserved for issuance under
the Plan from 5,300,000 to 6,050,000.

<PAGE>

         The  Board  believes  the  proposed  increase  in the  number of shares
reserved for issuance under the Plan is in the best interests of the Company. In
particular,  the Board has determined that the proposed increase will provide an
additional  reserve of shares for  issuance  under the Plan and thus  enable the
Company to attract and retain valuable employees.

     As of April 7, 2000, there were options  outstanding to purchase  3,217,127
shares of Common Stock  pursuant to the 1992 Stock Plan;  4,622 shares  remained
available  for  future  option  grants  subject  to  stockholder  approval;  and
2,078,251 options were exercised and are now outstanding shares of Common Stock.
Under this Plan,  options and stock purchase  rights may be granted to employees
and consultants of the Company. As of the record date, there were 156 employees,
approximately  20  consultants.  Pending  shareholder  approval to increase  the
number  of shares  available  for grant  under the Plan,  an option to  purchase
160,000  shares  will be  granted  to Paul W.  Hawran  at an  exercise  price of
$23.375.

SUMMARY OF THE PLAN

         The  essential  features  of the Plan,  as amended  and  restated,  are
summarized  below.  This  summary does not purport to be complete and is subject
to, and  qualified by,  reference to all  provisions of the Plan, as amended and
restated.

         General.  The  purpose  of the Plan is to  attract  and retain the best
available  personnel,  to provide  additional  incentive  to the  employees  and
consultants of the Company and to promote the success of the Company's business.
Options and stock purchase rights may be granted under the Plan. Options granted
under the Plan may be either  "incentive  stock  options," as defined in Section
422 of the Internal Revenue Code (the "Code"), or nonstatutory stock options.

         Administration.  The Plan may generally be administered by the Board of
Directors or a Committee  appointed by the Board. Gary A. Lyons was appointed by
the Board as the administrator of the Plan, herein as the  "Administrator."  The
Administrator may make any determinations  deemed necessary or advisable for the
Plan.

         Eligibility.  Nonstatutory  stock options and stock purchase rights may
be granted under the Plan to employees and consultants  (including Directors) of
the Company and any parent or subsidiary of the Company. Incentive stock options
may be granted only to employees. The Administrator,  in its discretion, selects
the employees and  consultants to whom options and stock purchase  rights may be
granted, the time or times at which such options and stock purchase rights shall
be granted, and the number of shares subject to each such grant.

         Limitations.   Section   162(m)  of  the  Code  places  limits  on  the
deductibility  for federal income tax purposes of  compensation  paid to certain
executive officers of the Company. In order to preserve the Company's ability to
deduct the compensation income associated with options and stock purchase rights
granted to such persons,  the Plan provides that no employee may be granted,  in
any fiscal year of the Company,  options and stock  purchase  rights to purchase
more than 250,000 shares of Common Stock.  Notwithstanding this limit,  however,
in connection with an employee's  initial  employment,  he or she may be granted
options or stock purchase rights to purchase up to an additional  250,000 shares
of Common Stock.

         Terms and  Conditions  of Options.  Each option is evidenced by a stock
option  agreement  between the Company and the  optionee,  and is subject to the
following additional terms and conditions:

         (a) Exercise Price. The Administrator  determines the exercise price of
options at the time the options are granted.  The exercise price of an incentive
stock  option may not be less than 100% of the fair  market  value of the Common
Stock on the date such option is granted; provided,  however, the exercise price
of an incentive  stock option granted to a 10%  shareholder may not be less than
110% of the fair  market  value of the Common  Stock on the date such  option is

<PAGE>

granted.  The exercise price of a nonstatutory stock option may not be less than
85% of the fair  market  value of the  Common  Stock on the date such  option is
granted;  provided,  however,  the exercise price of a nonstatutory stock option
granted to a 10%  shareholder may not be less than 110% of the fair market value
of the Common Stock on the date such option is granted. The fair market value of
the Common  Stock is  generally  determined  with  reference to the closing sale
price for the Common Stock (or the closing bid if no sales were reported) on the
last market trading day prior to the date the option is granted.

         (b)  Exercise  of  Option;  Form of  Consideration.  The  Administrator
determines  when  options  become   exercisable  and  may,  in  its  discretion,
accelerate  the  vesting of any  outstanding  option.  The means of payment  for
shares issued upon exercise of an option is specified in each option  agreement.
The Plan  permits  payment to be made by cash,  check,  promissory  note,  other
shares  of  Common  Stock of the  Company  (with  some  restrictions),  cashless
exercise,  any other form of  consideration  permitted by applicable law, or any
combination thereof.

         (c) Term of  Option.  The term of  option  may be no more than 10 years
from the date of grant;  provided that in the case of an incentive  stock option
granted  to a 10%  shareholder,  the term of the option may be no more than five
(5)  years  from the  date of  grant.  No  option  may be  exercised  after  the
expiration of its term.

         (d)  Termination  of  Employment.   If  an  optionee's   employment  or
consulting   relationship  terminates  for  any  reason  (other  than  death  or
disability),  then all options held by the optionee under the Plan expire on the
earlier of (i) the date set forth in his or her notice of grant  (which  date is
typically 90 days after the date of such  termination),  or (ii) the  expiration
date of such option.  To the extent the option is exercisable at the time of the
optionee's  termination,  the  optionee  may  exercise all or part of his or her
option at any time before it terminates.

         (e) Disability.  If an optionee's employment or consulting relationship
terminates  as a result of  disability,  then all options held by such  optionee
under  the Plan  expire  on the  earlier  of (i) 6 months  from the date of such
termination (or such longer period of time not exceeding 12 months as determined
by the  Administrator) or (ii) the expiration date of such option.  The optionee
(or the optionee's estate or a person who has acquired the right to exercise the
option by bequest or inheritance)  may exercise all or part of the option at any
time before such expiration to the extent that the option was exercisable at the
time of such termination.

         (f)  Death.  In the  event  of an  optionee's  death:  (i)  during  the
optionee's  employment or consulting  relationship with the Company,  the option
may be exercised, at any time within 6 months of the date of death (but no later
than the expiration  date of such option) by the  optionee's  estate or a person
who has acquired the right to exercise the option by bequest or inheritance, but
only to the extent that the  optionee's  right to exercise the option would have
accrued if he or she had  remained an employee  or  consultant  of the Company 6
months after the date of death;  or (ii) within 30 days (or such other period of
time not  exceeding  3 months  as  determined  by the  Administrator)  after the
optionee's  employment or consulting  relationship with the Company  terminates,
the option may be exercised at anytime  within 6 months (or such other period of
time as determined by the Administrator)  following the date of death (but in no
event later than the expiration date of the option) by the optionee's  estate or
a person  who has  acquired  the right to  exercise  the  option by  bequest  or
inheritance,  but only to the extent of the  optionee's  right to  exercise  the
option at the date of termination.

         (g)  Nontransferability of Options:  Unless otherwise determined by the
Administrator, options granted under the Plan are not transferable other than by
will or the laws of descent and distribution,  and may be exercisable during the
optionee's lifetime only by the optionee.

         (h) Other  Provisions:  The stock option  agreement  may contain  other
terms,  provisions  and  conditions  not  inconsistent  with  the Plan as may be
determined by the Administrator.

         The Plan has been  amended to provide that upon the  retirement  of any
Company  employee  at age 55 or greater  following 5 or more years of service to
the  Company,  all  stock  options  held  by  such  employee  will  vest  and be
exercisable for a term of 3 years from the date of retirement.

<PAGE>

         Stock  Purchase  Rights.  A stock  purchase right gives the purchaser a
period  of no longer  than 6 months  from the date of grant to  purchase  Common
Stock. The purchase price of Common Stock purchased pursuant to a stock purchase
right is  determined in the same manner as for  nonstatutory  stock  options.  A
stock purchase right is accepted by the execution of a restricted stock purchase
agreement  between the Company and the purchaser,  accompanied by the payment of
the  purchase  price  for  the  shares.  Unless  the  Administrator   determines
otherwise,  the  restricted  stock purchase  agreement  shall give the Company a
repurchase option  exercisable upon the voluntary or involuntary  termination of
the purchaser's  employment or consulting  relationship with the Company for any
reason  (including  death and  disability).  The  purchase  price for any shares
repurchased  by the Company shall be the original  price paid by the  purchaser.
The repurchase option lapses at a rate determined by the Administrator.  A stock
purchase right is nontransferable  other than by will or the laws of descent and
distribution,  and may be exercisable during the optionee's lifetime only by the
optionee.

         Adjustments Upon Changes in Capitalization. In the event that the stock
of the Company changes by reason of any stock split,  reverse stock split, stock
dividend,  combination,  reclassification or other similar change in the capital
structure  of  the  Company  effected  without  the  receipt  of  consideration,
appropriate adjustments shall be made in the number and class of shares of stock
subject  to the Plan,  the  number  and class of shares of stock  subject to any
option or stock  purchase  right  outstanding  under the Plan,  and the exercise
price of any such outstanding option or stock purchase right.

         In the event of a liquidation or dissolution,  any unexercised  options
or stock purchase  rights will  terminate.  The  Administrator  shall notify the
optionee 15 days prior to the consummation of the liquidation or dissolution.

         In connection with any merger, consolidation,  acquisition of assets or
like occurrence involving the Company, each outstanding option or stock purchase
right may be assumed or an equivalent  option or right may be substituted by the
successor corporation.  The vesting of each outstanding option or stock purchase
right shall accelerate (i.e. become  exercisable  immediately in full) in any of
the following  events:  (1) if the successor  corporation  refuses to assume the
option or stock  purchase  rights,  or to  substitute  substantially  equivalent
options  or rights,  (2) if the  employment  of the  optionee  is  involuntarily
terminated  without  cause within one year  following the date of closing of the
merger or  acquisition,  or (3) if the merger or  acquisition is not approved by
the members of the board of  directors in office  prior to the  commencement  of
such merger or acquisition.

         Amendment  and  Termination  of the Plan.  The Board may amend,  alter,
suspend or  terminate  the Plan,  or any part  thereof,  at any time and for any
reason. However, the Company shall obtain shareholder approval for any amendment
to the Plan to the extent  necessary to comply with applicable  laws,  rules and
regulations. No such action by the Board or shareholders may alter or impair any
option or stock  purchase  right  previously  granted under the Plan without the
consent of the optionee. Unless terminated earlier, the Plan shall terminate ten
years  from the date of its  approval  by the  shareholders  or the Board of the
Company, whichever is earlier.

FEDERAL INCOME TAX CONSEQUENCES

         Incentive Stock Options.  An optionee who is granted an incentive stock
option does not  recognize  taxable  income at the time the option is granted or
upon its exercise,  although the exercise is an adjustment  item for alternative
minimum tax  purposes and may subject the  optionee to the  alternative  minimum
tax.  Upon a  disposition  of the shares  more than two years after grant of the
option and one year after exercise of the option, any gain or loss is treated as
long-term  capital  gain or loss.  Net capital  gains on shares held one year or
less may be taxed at a maximum  federal rate of 28%,  while net capital gains on

<PAGE>

shares  held for more  than one year may be taxed at a maximum  federal  rate of
20%.  Capital losses are allowed in full against  capital gains and up to $3,000
against other income.  If these holding periods are not satisfied,  the optionee
recognizes  ordinary  income at the time of disposition  equal to the difference
between the  exercise  price and the lower of (i) the fair  market  value of the
shares at the date of the option  exercise or (ii) the sale price of the shares.
Any gain or loss  recognized  on such a premature  disposition  of the shares in
excess of the amount  treated as  ordinary  income is  treated as  long-term  or
short-term  capital gain or loss,  depending on the holding period.  A different
rule for measuring  ordinary income upon such a premature  disposition may apply
if the optionee is also an officer, Director, or 10% shareholder of the Company.
Unless  limited by Section  162(m) of the Code,  the  Company is  entitled  to a
deduction in the same amount as the ordinary income recognized by the optionee.

         Nonstatutory Stock Options.  An optionee does not recognize any taxable
income  at the time he or she is  granted  a  nonstatutory  stock  option.  Upon
exercise,  the optionee  recognizes  taxable  income  generally  measured by the
excess of the then fair market value of the shares over the exercise price.  Any
taxable income  recognized in connection  with an option exercise by an employee
of the Company is subject to tax  withholding by the Company.  Unless limited by
Section  162(m) of the Code,  the Company is entitled to a deduction in the same
amount as the ordinary income recognized by the optionee.  Upon a disposition of
such  shares by the  optionee,  any  difference  between  the sale price and the
optionee's  exercise  price,  to the extent not  recognized as taxable income as
provided  above,  is treated as  long-term or  short-term  capital gain or loss,
depending on the holding  period.  Net capital  gains on shares held one year or
less may be taxed at a maximum  federal rate of 28%,  while net capital gains on
shares held for more than one year may be taxed at the capital gains rate.

         Stock Purchase Rights. Stock purchase rights will generally be taxed in
the same manner as  nonstatutory  stock options.  However,  restricted  stock is
generally  purchased upon the exercise of a stock purchase right. At the time of
purchase,  restricted  stock is subject to a  "substantial  risk of  forfeiture"
within the meaning of Section 83 of the Code, because the Company may repurchase
the stock when the  purchaser  ceases to provide  services to the Company.  As a
result of this substantial risk of forfeiture,  the purchaser will not recognize
ordinary income at the time of purchase.  Instead,  the purchaser will recognize
ordinary  income  on  the  dates  when  the  stock  is no  longer  subject  to a
substantial  risk of forfeiture  (i.e.,  when the Company's  right of repurchase
lapses).  The purchaser's  ordinary income is measured as the difference between
the purchase  price and the fair market value of the stock on the date the stock
is no longer subject to right of repurchase.

         The  purchaser  may  accelerate  to the  date  of  purchase  his or her
recognition  of ordinary  income,  if any,  and begin his or her  capital  gains
holding period by timely  filing,  (i.e.,  within 30 days of the  purchase),  an
election  pursuant to Section  83(b) of the Code.  In such event,  the  ordinary
income  recognized,  if any, is measured as the difference  between the purchase
price and the fair market  value of the stock on the date of  purchase,  and the
capital  gain  holding  period  commences  on such  date.  The  ordinary  income
recognized by a purchaser who is an employee would be subject to tax withholding
by the Company.  Different  rules may apply if the purchaser is also an officer,
Director, or 10% shareholder of the Company.

         The  foregoing  is only a  summary  of the  effect  of  federal  income
taxation upon optionees,  holders of stock purchase rights, and the Company with
respect to the grant and exercise of options and stock purchase rights under the
Plan.  It does  not  purport  to be  complete,  and  does  not  discuss  the tax
consequences  of the employee's or  consultant's  death or the provisions of the
income  tax laws of any  municipality,  state or  foreign  country  in which the
employee or consultant may reside.

VOTE REQUIRED

         At the Annual Meeting,  the shareholders are being asked to approve the
amendment  of the 1992  Incentive  Stock Plan to  increase  the number of shares
reserved  for  issuance  thereunder.  The  affirmative  vote of the holders of a
majority  of the  shares  casting  their  votes at the  Annual  Meeting  will be
required to approve  the  amendment  of the 1992  Incentive  Plan.  The Board of
Directors  recommends  voting "FOR" the  amendment of the 1992  Incentive  Stock
Plan.

<PAGE>

                                 PROPOSAL THREE:

         APPROVAL OF AMENDMENT OF THE 1996 EMPLOYEE STOCK PURCHASE PLAN

INCREASE OF 300,000 SHARES

         The  Company's  1996  Employee  Stock  Purchase  Plan,  as amended (the
"ESPP")  was  approved by the Board of  Directors  and the  stockholders  of the
Company in 1996.  Currently  there are a total of 125,000 shares of Common Stock
reserved for issuance  under the ESPP.  As of the record date,  there were 2,398
shares available for future issuance.  Any employee employed by the Company on a
given enrollment date is eligible to participate in the ESPP. Eligibility may be
disqualified  for a given period  pursuant to Section  424(d) of the Code. As of
the record date, there were 156 employees, 107 of which are participating in the
current purchase period.

         The  Board  believes  the  proposed  increase  in the  number of shares
reserved for issuance under the ESPP is in the best interests of the Company. In
particular,  the Board has determined that the proposed increase will provide an
additional  reserve of shares for  issuance  under the ESPP and thus  enable the
Company to attract and retain valuable employees.

SUMMARY OF ESPP

         The essential  features of the ESPP are summarized  below. This summary
does not purport to be complete and is subject to, and qualified  by,  reference
to all provisions of the ESPP.

         General. The purpose of the ESPP is to provide employees of the Company
and its Designated  Subsidiaries with an opportunity to purchase Common Stock of
the Company through accumulated  payroll deductions.  It is the intention of the
Company to have the ESPP  qualify as an  "Employee  Stock  Purchase  Plan" under
Section  423 of the Code.  The  provisions  of the ESPP,  accordingly,  shall be
construed so as to extend and limit  participation  in a manner  consistent with
the requirements of that section of the Code.

         Administration.  The  ESPP  shall  be  administered  by the  Board or a
committee  of members of the Board  appointed  by the Board.  Paul W. Hawran and
Margaret E.  Valeur-Jensen  were appointed by the Board as administrators of the
ESPP.  The Board or its committee  shall have full and  exclusive  discretionary
authority  to construe,  interpret  and apply the terms of the ESPP to determine
eligibility  and to adjudicate all disputed  claims filed under the ESPP.  Every
finding, decision and determination made by the Board or its committee shall, to
the full extent permitted by law, be final and binding upon all parties.

         Eligibility.  Any employee, as defined in the ESPP document,  who shall
be  employed  by the Company on a given  Enrollment  Date  (January 1 or July 1)
shall be eligible to  participate in the ESPP. Any provisions of the ESPP to the
contrary notwithstanding,  no employee shall be granted an option under the ESPP
(i) if  immediately  after the grant,  such  employee (or any other person whose
stock would be  attributed to such  employee  pursuant to Section  424(d) of the
Code) would own capital stock of the Company and/or hold outstanding  options to
purchase such stock possessing 5%) or more of the total combined voting power or
value of all classes of the capital  stock of the Company or of any  Subsidiary,
or (ii) if such option  permits  his or her rights to  purchase  stock under all
employee stock purchase plans of the Company and its subsidiaries to accrue at a
rate which exceeds  $25,000 worth of stock  (determined at the fair market value
of the shares at the time such  option is  granted)  for each  calendar  year in
which such option is outstanding at any time.

<PAGE>

         Offering  Periods.  The  ESPP  shall  be  implemented  by  consecutive,
overlapping  Offering  Periods  (each 24 months in length)  with a new  Offering
Period  beginning on the first Trading Day on or after July 1 and January 1 each
year,  or on such  other  date as the  Board  shall  determine,  and  continuing
thereafter  until terminated in accordance with Section 19 of the ESPP document.
The  first  day of the  Offering  Period  shall  be the  effective  date  of the
Company's  initial public  offering of its Common Stock that is registered  with
the SEC.  The Board  shall have the power to change  the  duration  of  Offering
Periods  (including  the  commencement  dates  thereof)  with  respect to future
offerings  without  stockholder  approval if such change is announced at least 5
days  prior to the  scheduled  beginning  of the  first  Offering  Period  to be
affected thereafter.

         Purchase Periods. Each Offering Period shall be comprised of 4 Purchase
Periods, each 6 months in length. Each Purchase Period shall begin one day after
the last Exercise Date and end with the next Exercise Date. Exercise Dates shall
occur on or about June 30 and December 31 of each year.

         Payroll  Deductions.  At  the  time  a  participant  files  his  or her
subscription agreement, he or she shall elect to have payroll deductions made on
each pay day  during the  Offering  Period in an amount not to exceed 15% of the
Compensation  which he or she  receives  on each  pay day  during  the  Offering
Period,  and the aggregate of such payroll deductions during the Offering Period
shall not exceed 15% of the  participant's  Compensation  during  said  Offering
Period.

         All payroll  deductions made for a participant shall be credited to his
or her account under the ESPP and will be withheld in whole  percentages only. A
participant  may  not  make  any  additional   payments  into  such  account.  A
participant  may decrease the  percentage of payroll  deduction once during each
purchase period and may discontinue  participation at any time. Upon termination
of employment, any cash balances in the participants account will be refunded in
full. No interest will accrue on payroll deductions of a participant.

         Grant of Option.  On the Enrollment Date of each Offering Period,  each
eligible  participant  in the  Offering  period  shall be  granted  an option to
purchase shares of Common Stock on each Exercise Date during the Offering Period
at the applicable  Purchase Price.  The number of shares of the Company's Common
Stock determined by dividing the  participants  payroll  deductions  accumulated
prior to such Exercise Date and retained in the participant's  account as of the
Exercise Date, by the applicable  Purchase Price.  The number of shares eligible
for options are subject to limitations defined in the ESPP's document.

         Purchase  Price.  The Purchase  Price shall be equal to 85% of the Fair
Market Value of the Common Stock on the  Enrollment  Date or the Exercise  Date,
which ever is lower.

         Exercise of Option.  Unless a participant  withdraws  from the ESPP, as
provided in Section 10 the ESPP document,  his or her option for the purchase of
shares will be exercised  automatically on the Exercise Date. Upon exercise, the
maximum  number of full shares  subject to option  shall be  purchased  for such
participant  at the  applicable  Purchase  Price  with the  accumulated  payroll
deductions in his or her account.  No fractional  shares will be purchased;  any
payroll  deductions  accumulated  in  a  participant's  account  which  are  not
sufficient  to  purchase a full share  shall be  retained  in the  participant's
account  for the  subsequent  Purchase  Period or  Offering  Period,  subject to
earlier  withdrawal  by the  participant  as  provided in Section 10 of the ESPP
document.  Any other  monies  left  over in a  participant's  account  after the
Exercise  Date shall be  returned  to the  participant.  During a  participant's
lifetime,  a participant's  option to purchase  shares  hereunder is exercisable
only by him or her.

         Limitations.  Notwithstanding  the provisions of Subsection (a) of this
Section 13, in the event that Rule 16b-3  promulgated under the Exchange Act, or
any successor  provision ("Rule 16b-3") provides  specific  requirements for the
administrators  of plans of this type,  the ESPP shall be only  administered  by
such  a body  and  in  such  a  manner  as  shall  comply  with  the  applicable
requirements  of Rule  16b-3.  Unless  permitted  by Rule 16b-3,  no  discretion
concerning  decisions  regarding  the ESPP shall be afforded to any committee or
person that is not "disinterested" as that term is used in Rule 16b-3.

<PAGE>

         Designation  of  Beneficiary.  (a) A  participant  may  file a  written
designation of a beneficiary who is to receive any shares and cash, if any, from
the  participant's  account  under the ESPP in the  event of such  participant's
death  subsequent to an Exercise Date on which the option is exercised but prior
to  delivery  to such  participant  of such  shares  and cash.  In  addition,  a
participant  may file a written  designation of a beneficiary  who is to receive
any cash  from the  participant's  account  under  the ESPP in the event of such
participant's death prior to exercise of the option. If a participant is married
and the  designated  beneficiary  is not the spouse,  spousal  consent  shall be
required for such designation to be effective.

                  (b) Such  designation  of  beneficiary  may be  changed by the
participant  at any time by  written  notice.  In the  event  of the  death of a
participant  and in the absence of a beneficiary  validly  designated  under the
ESPP who is living at the time of such  participant's  death,  the Company shall
deliver such shares and/or cash to the executor or  administrator  of the estate
of the participant,  or if no such executor or administrator  has been appointed
(to the knowledge of the Company),  the Company, in its discretion,  may deliver
such  shares  and/or  cash to the  spouse  or to any one or more  dependents  or
relatives of the participant, or if no spouse, dependent or relative is known to
the Company, then to such other person as the Company may designate.

         Transferability. Neither payroll deductions credited to a participant's
account nor any rights  with  regard to the  exercise of an option or to receive
shares  under  the ESPP  may be  assigned,  transferred,  pledged  or  otherwise
disposed of in any way (other than by will, the laws of descent and distribution
or as provided  in Section 14 hereof) by the  participant.  Any such  attempt at
assignment,  transfer,  pledge or other  disposition  shall be  without  effect,
except that the Company may treat such act as an election to withdraw funds from
an Offering Period in accordance with Section 10 hereof.

         Use of Funds.  All payroll  deductions  received or held by the Company
under the ESPP may be used by the Company  for any  corporate  purpose,  and the
Company shall not be obligated to segregate such payroll deductions.

         Reports. Individual accounts will be maintained for each participant in
the ESPP.  Statements  of account  will be given to  participating  Employees at
least  annually,  which  statements  will  set  forth  the  amounts  of  payroll
deductions, the Purchase Price, the number of shares purchased and the remaining
cash balance, if any.

     Adjustments  Upon  Changes  in  Capitalization,  Dissolution,  Liquidation,
Merger or Asset Sale.  (a) Changes in  Capitalization.  Subject to any  required
action by the shareholders of the Company, the Reserves as well as the price per
share of Common  Stock  covered by each option  under the ESPP which has not yet
been exercised shall be proportionately adjusted for any increase or decrease in
the  number of  issued  shares of Common  Stock  resulting  from a stock  split,
reverse stock split,  stock  dividend,  combination or  reclassification  of the
Common  Stock,  or any other  increase  or  decrease  in the number of shares of
Common Stock effected without receipt of consideration by the Company; provided,
however, that conversion of any convertible  securities of the Company shall not
be  deemed  to have been  "effected  without  receipt  of  consideration".  Such
adjustment shall be made by the Board, whose determination in that respect shall
be final,  binding and  conclusive.  Except as  expressly  provided  herein,  no
issuance  by the  Company  of  shares  of  stock  of any  class,  or  securities
convertible into shares of stock of any class,  shall affect,  and no adjustment
by reason  thereof  shall be made with respect to, the number or price of shares
of Common Stock subject to an option.

                  (b) Dissolution or  Liquidation.  In the event of the proposed
dissolution or liquidation of the Company,  the Offering  Periods will terminate
immediately prior to the consummation of such proposed action,  unless otherwise
provided by the Board.

<PAGE>

                  (c) Merger or Asset Sale.  In the event of a proposed  sale of
all or  substantially  all of the  assets of the  Company,  or the merger of the
Company  with or into another  corporation,  each option under the ESPP shall be
assumed  or  an  equivalent  option  shall  be  substituted  by  such  successor
corporation or a parent or subsidiary of such successor corporation,  unless the
Board  determines,  in the exercise of its sole  discretion  and in lieu of such
assumption or substitution,  to shorten the Offering Periods then in progress by
setting a new Exercise Date (the "New Exercise Date"). If the Board shortens the
Offering  Periods then in progress in lieu of assumption or  substitution in the
event of a merger or sale of assets,  the Board shall notify each participant in
writing,  at least 10 business  days prior to the New  Exercise  Date,  that the
Exercise  Date for his option has been changed to the New Exercise Date and that
his option will be  exercised  automatically  on the New Exercise  Date,  unless
prior to such date he has  withdrawn  from the  Offering  Period as  provided in
Section 10 hereof.  For purposes of this paragraph,  an option granted under the
ESPP shall be deemed to be assumed if,  following  the sale of assets or merger,
the option confers the right to purchase, for each share of option stock subject
to  the  option  immediately  prior  to  the  sale  of  assets  or  merger,  the
consideration  (whether stock, cash or other securities or property) received in
the sale of assets or merger by holders of Common Stock for each share of Common
Stock held on the effective  date of the  transaction  (and if such holders were
offered  a choice  of  consideration,  the type of  consideration  chosen by the
holders of a majority  of the  outstanding  shares of Common  Stock);  provided,
however, that if such consideration received in the sale of assets or merger was
not solely common stock of the successor  corporation  or its parent (as defined
in Section 424(e) of the Code), the Board may, with the consent of the successor
corporation,  provide for the  consideration to be received upon exercise of the
option to be solely  common  stock of the  successor  corporation  or its parent
equal in fair market value to the per share consideration received by holders of
Common Stock and the sale of assets or merger.

         Amendment or Termination. (a) The Board of Directors of the Company may
at any time and for any reason  terminate or amend the ESPP.  Except as provided
in Section 18 hereof, no such termination can affect options previously granted,
provided that an Offering  Period may be terminated by the Board of Directors on
any Exercise Date if the Board determines that the termination of the ESPP is in
the best  interests of the Company and its  shareholders.  Except as provided in
Section 18 hereof,  no amendment  may make any change in any option  theretofore
granted which  adversely  affects the rights of any  participant.  To the extent
necessary  to comply  with Rule 16b-3 or under  Section  423 of the Code (or any
successor  rule or provision or any other  applicable  law or  regulation),  the
Company shall obtain shareholder  approval in such a manner and to such a degree
as required.

                  (b) Without  shareholder consent and without regard to whether
any participant rights may be considered to have been "adversely  affected," the
Board (or its committee) shall be entitled to change the Offering Periods, limit
the frequency and/or number of changes in the amount withheld during an Offering
Period,  establish  the  exchange  ratio  applicable  to amounts  withheld  in a
currency other than U.S.  dollars,  permit payroll  withholding in excess of the
amount  designated by a participant in order to adjust for delays or mistakes in
the Company's processing of properly completed withholding elections,  establish
reasonable  waiting and  adjustment  periods  and/or  accounting  and  crediting
procedures  to ensure that amounts  applied  toward the purchase of Common Stock
for  each  participant  properly  correspond  with  amounts  withheld  from  the
participant's  Compensation,  and establish such other limitations or procedures
as the Board (or its  committee)  determines  in its sole  discretion  advisable
which are consistent with the ESPP.

         Notices.  All notices or other  communications  by a participant to the
Company under or in  connection  with the ESPP shall be deemed to have been duly
given when received in the form specified by the Company at the location,  or by
the person, designated by the Company for the receipt thereof.

         Conditions  Upon  Issuance of Shares.  Shares  shall not be issued with
respect to an option  unless the  exercise of such option and the  issuance  and
delivery of such  shares  pursuant  thereto  shall  comply  with all  applicable
provisions  of law,  domestic or foreign,  including,  without  limitation,  the
Securities  Act,  the  Exchange  Act,  the  rules  and  regulations  promulgated
thereunder, and the requirements of any stock exchange upon which the shares may
then be listed,  and shall be further subject to the approval of counsel for the
Company with respect to such compliance.

<PAGE>

         As a condition  to the  exercise of an option,  the Company may require
the person  exercising  such option to represent  and warrant at the time of any
such  exercise  that the  shares are being  purchased  only for  investment  and
without  any  present  intention  to sell or  distribute  such shares if, in the
opinion of counsel for the Company,  such a representation is required by any of
the aforementioned applicable provisions of law.

         Term of Plan. The ESPP shall become effective upon the earlier to occur
of its adoption by the Board of Directors or its approval by the shareholders of
the Company.  It shall  continue in effect for a term of 10 years unless  sooner
terminated under Section 19 hereof.

VOTE REQUIRED

         At the Annual Meeting,  the shareholders are being asked to approve the
amendment of the 1996  Employee  Stock  Purchase  Plan to increase the number of
shares reserved for issuance thereunder.  The affirmative vote of the holders of
a majority  of the shares  casting  their  votes at the Annual  Meeting  will be
required to approve the amendment of the 1996 Employee  Stock Purchase Plan. The
Board of Directors  recommends  voting "FOR" the  amendment of the 1996 Employee
Stock Purchase Plan.

<PAGE>
                                 PROPOSAL FOUR:

                AMENDMENT OF THE 1996 DIRECTORS STOCK OPTION PLAN

INCREASE OF 100,000 SHARES

         The Directors  Plan was adopted by the Board of Directors in March 1996
and approved by the  stockholders  at the  Company's  1996 annual  stockholders'
meeting.  A total of 200,000  shares of Common  Stock is reserved  for  issuance
under the  Directors  Plan.  The  option  grants  under the  Directors  Plan are
automatic  and the  exercise  price of the  options  are 100% of the fair market
value of the Common  Stock on the grant  date.  As the record  date,  there were
96,113 options outstanding, 29,718 were exercised and issued as Common Stock and
74,169 remained  available for grant.  Options under the Directors Plan may only
be granted to outside  Directors.  As of the record  date,  there were 4 outside
Directors.

SUMMARY OF THE DIRECTORS PLAN

         The essential  features of the Director Plan are summarized below. This
summary  does not purport to be complete  and is subject to, and  qualified  by,
reference to all provisions of the Directors Plan.

         Eligibility.  The  Director  Plan  provides  for each new  non-employee
Director is automatically  granted nonstatutory stock options to purchase 15,000
shares of the  Company's  Common Stock upon the date such person joins the Board
of Directors and a grant of options to purchase 12,000 shares of Common Stock at
each annual meeting (Dr. Mollica, as Chairman of the Board,  receives a grant of
15,000  options)  of  the  stockholders   commencing  in  1997,  providing  such
non-employee  director  has been a  non-employee  director of the Company for at
least 6 months prior to the date of such annual meeting of the stockholders.

<PAGE>

         Grant of Options.  Options under the Directors  Plan are  automatically
granted  on the date a person  joins the Board of  Directors  and on the date of
each subsequent annual meeting subject to eligibility requirements.  The term of
such options is 10 years. Any option granted to a non-employee  director becomes
exercisable over a 3-year period following the date of grant.

         Transferability.  The  Director  Plan  prohibits  any  transfer  by the
optionee other than by will or the laws of descent or distribution. Any optionee
whose  relationship with the Company or any related  corporation  ceases for any
reason  (other than by death or  permanent  and total  disability)  may exercise
options  only during a 90-day  period  following  such  cessation  (unless  such
options terminate or expire sooner by their terms).

         Merger or Asset  Sale.  Upon a merger or asset  sale,  all  outstanding
options  under the Director  Plan will be assumed or replaced with an equivalent
option by the successor corporation. In the event that the successor corporation
does not agree to assume the  outstanding  options or  substitute  an equivalent
option,  each  outstanding  option shall  become  fully vested and  exercisable,
including as to shares not otherwise exercisable. Each optionee will be given 30
days' notice of the merger or asset sale and be given the  opportunity  to fully
exercise all outstanding  options.  All options not exercised  within the 30-day
notice period will expire.

     Termination.  The Director Plan will terminate in March 2006, unless sooner
terminated by the Board of Directors.

Vote Required

         At the Annual Meeting,  the shareholders are being asked to approve the
amendment  of the 1996  Directors  Stock  Option Plan to increase  the number of
shares reserved for issuance thereunder.  The affirmative vote of the holders of
a majority  of the shares  casting  their  votes at the Annual  Meeting  will be
required to approve the amendment of the Directors  Plan. The Board of Directors
recommends voting "FOR" the amendment of the 1996 Directors Stock Option Plan.



                                 PROPOSAL FIVE:

          RATIFICATION OF APPOINTMENT OF INDEPENDENT PUBLIC ACCOUNTANTS

         The  Board of  Directors  has  selected  Ernst & Young  LLP  ("Ernst  &
Young"), to audit the financial statements of the Company for the current fiscal
year ending December 31, 2000. Ernst & Young has audited the Company's financial
statements  since  1992.  Representatives  of Ernst & Young are  expected  to be
present at the meeting, will have the opportunity to make a statement if they so
desire, and are expected to be available to respond to appropriate questions.

         The  affirmative  vote  of the  holders  of a  majority  of the  shares
represented and voting at the meeting will be required to approve and ratify the
Board's  selection of Ernst & Young.  The Board of Directors  recommends  voting
"FOR" approval and  ratification of such  selection.  In the event of a negative
vote on such ratification, the Board of Directors will reconsider its selection.


<PAGE>



                     OTHER INFORMATION REGARDING THE COMPANY

PERFORMANCE GRAPH

         The following is a line graph comparing the cumulative  total return to
stockholders  of the  Company's  Common Stock from May 23, 1996 (the date of the
Company's  initial public offering)  through December 31, 1999 to the cumulative
total return over such period of: (i) The Nasdaq  Stock Market (U.S.  Companies)
Index and (ii) the Nasdaq  Pharmaceutical  Index.  The performance  shown is not
necessarily indicative of future price performance. The information contained in
the Performance  Graph shall not be deemed to be "soliciting  material" or to be
"filed" with the SEC, nor shall such  information be  incorporated  by reference
into any future filing under the Securities  Act, or the Exchange Act, except to
the extent that the Company  specifically  incorporates it by reference into any
such filing.

              COMPARISON OF CUMULATIVE TOTAL RETURN ON INVESTMENT

                                                  NASDAQ            NASDAQ
Measurement Period          Neurocrine          Stock Market     Biotechnology
(Fiscal Year Covered)     Biosciences,Inc.         (U.S.)            Index
- - - - ---------------------     ----------------    ----------------  ----------------
05/23/96                      100                   100                 100
12/31/96                       80                   103                  91
12/31/97                       63                   126                  91
12/31/98                       55                   176                 131
12/31/99                      198                   326                 265



<PAGE>

                               EXECUTIVE OFFICERS

         As of the record date,  the  executive  officers of the Company were as
follows:

Name                                   Age  Position
- - - - ----                                   ---  --------
Gary A. Lyons......................... 49   President, Chief Executive
                                              Officer and Director
Paul W. Hawran........................ 48   Executive Vice President

D. Bruce Campbell, Ph.D............... 55   Senior Vice President, Development

Margaret E. Valeur-Jensen, J.D., Ph.D. 43   Senior Vice President, General
                                             Counsel and Corporate Secretary

     See  Proposal One above for  biographical  information  concerning  Gary A.
Lyons.

         Paul W.  Hawran  became  Executive  Vice  President  of the  Company in
January 2000 after having served as Senior Vice  President  and Chief  Financial
Officer  of the  Company  since  February  1996 and  Vice  President  and  Chief
Financial  Officer  from 1993 to 1996.  In this  capacity,  Mr.  Hawran  directs
strategic planning,  finance, investor relations,  human resources,  information
technologies  and  operations.  Mr.  Hawran was employed by  SmithKline  Beecham
Corporation  from July 1984 to May 1993,  most  recently as Vice  President  and
Treasurer.  Prior  to  joining  SmithKline  in 1984,  Mr.  Hawran  held  various
financial  positions at Warner  Communications  (now Time  Warner)  where he was
involved in corporate finance, financial planning and domestic and international
budgeting and forecasting. Mr. Hawran received a B.S. in Finance from St. John's
University and an M.S. in Taxation from Seton Hall University. He is a Certified
Public  Accountant  and a member of the American  Institute of Certified  Public
Accountants,   California  and   Pennsylvania   Institute  of  Certified  Public
Accountants and the FinancialExecutives Institute.

D. Bruce  Campbell,  Ph.D.,  became Senior Vice  President,  Development  of the
Company  in January  2000 after  having  joined the  Company as Vice  President,
Development in February 1998. In his capacity,  he is responsible  for directing
Neurocrine's  selection and  advancement of drug  candidates  from research into
clinical  development.  He joined  Neurocrine  after 27 years at Servier  United
Kingdom (U.K.), a subsidiary of an international pharmaceutical company based in
France,  where he served as Director of International  Scientific  Affairs since
1991 and was involved in the  development  and  registration  of a wide range of
drugs and vaccines. Dr. Campbell is a past Chairman and Board Member of the Drug
Information  Association  (DIA) in Europe  and  member of the  ICH/EFPIA  Safety
Working  Party and is a visiting  Professor  in  Pharmacology  at Kings  College
London.  He is  recognized  as one of the experts on the  regulatory  aspects of
kinetics and toxicology in new drug  development and has written  standard texts
on the subject.  Dr.  Campbell is also in the editorial  board of  international
journals and a member of many  scientific  societies and has published more than
100 papers.

         Margaret  Valeur-Jensen,  J.D.,  Ph.D.,  became Senior Vice  President,
General  Counsel and  Corporate  Secretary  of the Company in January 2000 after
having joined the Company as Vice  President,  General  Counsel and Secretary in
October 1998. Dr. Valeur-Jensen has recognized  experience in legal transactions
for licensing,  corporate partnerships, and product commercialization as well as
in  building  intellectual  property  portfolios.  She is  responsible  for  all
corporate and patent law practices at Neurocrine,  serves as Corporate Secretary
and is a member of the senior management  committee.  Dr.  Valeur-Jensen  joined
Neurocrine after almost eight years at Amgen,  where she served most recently as
Associate   General   Counsel  and  Director.   Prior  to  joining  Amgen,   Dr.
Valeur-Jensen  practiced law at Davis,  Polk & Wardell,  a leading corporate law
firm. She earned a J.D. degree with honors from Stanford University,  a Ph.D. in
Biochemistry   and  Molecular   Biology  from  Syracuse   University,   and  was
Post-Doctoral  Fellow at  Massachusetts  General  Hospital  and Harvard  Medical
School.

<PAGE>

ADDITIONAL INFORMATION

         Officers  of the  Company  serve  at the  discretion  of the  Board  of
Directors.  There  are no  family  relationships  among  any  of the  Directors,
executive  officers  or key  employees.  No  executive  officer,  key  employee,
promoter,  or control  person of the Company  has, in the last five years,  been
subject to bankruptcy  proceedings,  criminal proceedings,  or legal proceedings
related to the violation of state or federal commodities or securities laws.

COMPENSATION OF EXECUTIVE OFFICERS

         Summary   Compensation  Table.  The  following  table  sets  forth  the
compensation  paid by the  Company  for each of the  three  fiscal  years in the
period ended  December 31, 1999 to the Chief  Executive  Officer and each of the
other  executive  officers of the  Company as of  December  31, 1999 (the "Named
Executive Officers"):

<TABLE>
<CAPTION>
                                                                                        Long-term
                                                 Annual Compensation              Compensation Awards
                                        ---------------------------------------  -----------------------

                                                                      Other      Restricted  Securities       All
                                                                     Annual         Stock    Underlying      Other
                                            Salary        Bonus    Compensation    Awards    Options      Compensation
Name and Principal Position        Year     ($) (1)      ($) (1)       ($)           ($)        (#)           ($)
- - - - -------------------------------------------------------------------------------------------------------------------------
<S>                                <C>     <C>      <C>     <C>                                  <C>          <C>    <C>
Gary A. Lyons                      1999    365,000  (2)    100,000      -             -          50,000       39,191 (3)
      President and Chief          1998    349,369  (2)     50,000      -             -          40,000       44,652 (3)
      Executive Officer            1997    325,296  (2)     55,000      -             -         175,000            -

Paul W. Hawran                     1999    235,200  (4)     60,000      -             -          25,000       50,930 (5)
      Executive Vice President     1998    224,667  (4)     35,000      -             -          25,000       59,716 (5)
                                   1997    209,073  (4)     40,000      -             -         115,000            -

Stephen G. Marcus                  1999    203,080  (6)          -      -             -          37,500       46,600 (8)
      Senior Vice President,       1998    231,000  (7)     42,500      -             -               -       31,755 (8)
      Clinical and Regulatory      1997    184,598  (7)     40,000      -             -         150,000      133,119 (8)
      Affairs and Chief Medical Officer

D. Bruce Campbell                  1999    216,667  (9)     60,000      -             -          25,000            -
      Senior Vice President,       1998    178,846  (9)     46,500      -             -         135,000(10)   40,000 (11)
       Development

Margaret E. Valeur-Jensen          1999    212,000 (12)     60,000      -             -               -      123,469 (13)
      Senior Vice President and    1998      5,000 (12)          -      -             -         115,000            -
      General Counsel

- - - - ----------
<FN>
(1)      Salary and bonus  figures are  amounts  earned  during each  respective
         fiscal  year,  regardless  of whether  part or all of such amounts were
         paid in subsequent fiscal year(s).

(2)      Represents  amounts  actually  paid to Mr. Lyons for the  corresponding
         fiscal years. Starting on January 1, 2000, Mr. Lyons' annualized salary
         became $385,000.

(3)      The totals  for 1999 and 1998  represents  forgiveness  of 1/3rd of Mr.
         Lyons' loan pursuant to his employment agreement dated March 1, 1997.

(4)      Represents  amounts  actually paid to Mr. Hawran for the  corresponding
         fiscal  years.  Starting on January 1, 2000,  Mr.  Hawran's  annualized
         salary became $260,000.

(5)      The totals  for 1999 and 1998  represents  forgiveness  of 1/3rd of Mr.
         Hawran's loan pursuant to his employment agreement dated March 1, 1997.

(6)      Dr. Marcus resigned from the Company on October 29, 1999.

(7)      Represents  amounts  actually paid to Dr. Marcus for the  corresponding
         fiscal  years.  Starting  on January 1, 1999,  Dr.  Marcus'  annualized
         salary became $243,700.

<PAGE>

(8)      Represents  payments made to Dr. Marcus in 1999 for severance ($40,000)
         and  mortgage  equalization  payments  ($6,600).  Amounts  paid in 1998
         represent  mortgage  equalization   payments.   Amounts  paid  in  1997
         represent  expenses  for  Dr.  Marcus's  relocation  to  the  Company's
         geographic region,  mortgage  equalization payments ($8,000), a sign-on
         bonus  ($25,000) and  reimbursement  of taxes incurred by Dr. Marcus in
         connection with relocation payments ($6,845).

(9)      Represents  amounts actually paid to Dr. Campbell for the corresponding
         fiscal years.  Starting on November 1, 1999, Dr. Campbell's  annualized
         salary became $240,000.

(10)     Represents  options granted to Dr. Campbell  pursuant to his consulting
         agreement dated September 1997 but contingent upon full-time employment
         in 1998 (125,000) and additional options granted during 1998 (10,000).

(11)     Represents  a  sign-on  bonus  ($20,000)  and  reimbursement  of moving
         expenses  ($20,000)  paid  to  Dr.  Campbell  in  connection  with  his
         relocation to the Company's geographic region.

(12)     Represents   amounts  actually  paid  to  Dr.   Valeur-Jensen  for  the
         corresponding   fiscal  years.   Starting  on  January  1,  2000,   Dr.
         Valeur-Jensen's annualized salary was $235,000.

(13)     Represents  payments  by the  Company in 1999 for  moving,  housing and
         other  expenses  and selling  costs  incurred by Dr.  Valeur-Jensen  in
         connection  with  selling her prior  residence  and  relocating  to the
         Company's  geographic  region  ($87,497)  and  reimbursement  for taxes
         associated with relocation reimbursements ($35,972).
</FN>
</TABLE>


         Option  Grants in Last  Fiscal  Year.  The  following  table sets forth
certain  information  concerning  grants of options  made  during the year ended
December 31, 1999 by the Company to each of the Named Executive Officers:

<TABLE>
<CAPTION>
                                                                                          Potential Realizable
                                                                                             Value at Assumed
                                                                                          Annual Rate of Stock
                                                                                            Appreciation for
                        Number of Shares      % of Total                                      Option Term (2)
                          Underlying      Options Granted   Exercise                    ------------------------
                        Options Granted   to Employees in   Price per
Name                         # (1)          Fiscal Year       Share     Expiration Date      5%          10%
- - - - ---------------------- ------------------ ----------------- ----------- --------------  ------------------------
<S>                         <C>                 <C>           <C>          <C>   <C>       <C>        <C>
Gary A. Lyons .........     50,000              7.5%          $5.375       03/02/09       $169,015    $428,318
Paul W. Hawran ........     25,000              3.7%          $5.375       03/02/09        $84,508    $214,159
Stephen G. Marcus .....     37,500              5.6%          $5.375       03/02/09       $126,762    $321,239
D. Bruce Campbell .....     25,000              3.7%          $5.375       03/02/09        $84,508    $214,159
- - - - ----------
<FN>

(1)      Options granted in 1999 to the officers listed above become exercisable
         as to 1/48th of the option  shares  each month  following  the  vesting
         start date,  with full vesting  occurring on the fourth  anniversary of
         the vesting  start date.  All options  listed  above were granted at an
         exercise  price equal to the fair market value of the Company's  Common
         Stock as determined by the Board of Directors on the date of grant. The
         exercise  price may be paid in cash,  promissory  note,  by delivery of
         already owned shares  subject to certain  conditions,  or pursuant to a
         cashless   exercise   procedure  under  which  the  optionee   provides
         irrevocable  instructions  to a  brokerage  firm to sell the  purchased
         shares and remit to the Company, out of sale proceeds,  an amount equal
         to the exercise price plus all applicable withholding taxes.

(2)      Potential  realizable  value is based on the assumption that the Common
         Stock of the Company  appreciates at the annual rate shown  (compounded
         annually)  from the  date of the  grant  until  the  expiration  of the
         ten-year  option  term.  These  numbers  are  calculated  based  on the
         requirements  promulgated by the Securities and Exchange Commission and
         do not reflect the Company's estimate of future stock price growth.

(3)      There were no options granted to Margaret E. Valeur-Jensen during 1999.
</FN>
</TABLE>

         Aggregate  Option  Exercises  in Last Fiscal  Year and Fiscal  Year-End
Values. The following table sets forth certain  information  regarding the stock
options  held at  December  31,  1999 by each of the Named  Executive  Officers.
During 1999, no such stock options were exercised by any of the Named  Executive
Officers. The Company has not granted any stock appreciation rights.


<PAGE>




                          Number of Shares Underlying    Value of Unexercised
                         Unexercised Options at Fiscal   In-the-Money Options
                                    Year-End           at Fiscal Year-End ($)(1)
                          --------------------------  ------------------------
Name                       Exercisable Unexercisable  Exercisable Unexercisable
- - - - -----------------------   --------------------------  -------------------------
Gary A. Lyons                 443,834    120,666       $8,909,445    $2,184,805
Paul W. Hawran                195,526     84,774       $3,274,489    $1,519,687
D. Bruce Campbell              67,926     92,074       $1,220,361    $1,676,514
Margaret E. Valeur-Jensen      28,763     86,237         $566,272    $1,697,791
- - - - ----------

(1)      "In-the-money" options are those for which the fair market value of the
         underlying securities exceeds the exercise or base price of the option.
         These  columns are based upon the closing  price of $24.75 per share on
         December 31, 1999,  minus the per share exercise  price,  multiplied by
         the number of shares underlying the option.


EMPLOYMENT AGREEMENTS

Gary A. Lyons has an  employment  contract  that  provides  that:  (i) Mr. Lyons
serves as the  Company's  President  and Chief  Executive  Officer for a term of
three years commencing on March 1, 1997 at an initial annual salary of $328,300,
subject to annual  adjustment by the Board of Directors (Mr.  Lyons' base salary
for 1998 was set at $346,375, $365,000 for 1999 and $385,000 for 2000); (ii) the
agreement will automatically  renew for three-year periods thereafter unless the
Company or Mr.  Lyons gives 90 days notice of  termination;  (iii) Mr.  Lyons is
eligible  for a  discretionary  annual  bonus  as  determined  by the  Board  of
Directors,  based upon achieving certain performance criteria;  (iv) the Company
has  provided  a  one-time  contract  renewal  bonus in the form of an option to
purchase 75,000 shares of the Company's Common Stock, exercisable at a price per
share equal to fair market  value on the date of grant,  which stock option will
vest over a four-year period,  (v) the Company has agreed to forgive the loan of
$67,500  made to  reimburse  Mr. Lyons for 50% of the loss on sale of his former
residence over a three-year period (based on continued employment); and (vi) Mr.
Lyons is  entitled  to  continue  to receive  his  salary,  health,  welfare and
retirement  benefits,  a pro rata  share of his  annual  bonus  and  vesting  of
outstanding  stock  options  for  twelve  months in the event  that the  Company
terminates his employment  without  cause,  or materially  reduces the power and
duties of his employment without cause, which will be deemed to be a termination
 . In the event of a change in control of the Company,  Mr.  Lyons would  receive
the same benefits  package as a termination  without  cause,  with the exception
that  the  vesting  for  all  outstanding   options  would  be  accelerated  and
immediately exercisable in full.

         Paul W. Hawran has an employment  contract that provides  that: (i) Mr.
Hawran serves as the Company's Senior Vice President and Chief Financial Officer
for a term of three  years  commencing  on March 1,  1997 at an  initial  annual
salary of $209,740,  subject to annual adjustment by the Board of Directors (Mr.
Hawran's  base  salary  for  1998  was set at  $224,000,  $235,200  for 1999 and
$260,000 for 2000), (ii) the agreement will  automatically  renew for three-year
periods  thereafter  unless the  Company or Mr.  Hawran  gives 90 days notice of
termination,  (iii) Mr. Hawran is eligible for a  discretionary  annual bonus as
determined by the Board of Directors  based upon achieving  certain  performance
criteria, (iv) the Company has agreed to forgive over a three-year period ending
on March 1, 2000 (based on  continued  employment)  the loan of $87,500  made to
reimburse Mr. Hawran for certain  housing and relocation  expenses,  and (v) Mr.
Hawran is  entitled to  continue  to receive  his  salary,  health,  welfare and
retirement  benefits,  a pro rata  share of his  annual  bonus  and  vesting  of
outstanding  stock  options  for  twelve  months in the event  that the  Company
terminates his employment  without  cause,  or materially  reduces the power and
duties  of  his  employment  without  cause,  which  will  be  deemed  to  be  a
termination.  In the event of a change in control  of the  Company,  Mr.  Hawran
would receive the same benefits package as a termination without cause, with the
exception that the vesting for all outstanding  options would be accelerated and
immediately exercisable in full.

<PAGE>

         D. Bruce  Campbell,  Ph.D.,  has an  employment  contract that provides
that: (i) Dr. Campbell serves as the Company's Vice President, Development for a
term of three years commencing on January 1, 1998 at an initial annual salary of
$200,000, subject to annual adjustment by the Board of Directors (Dr. Campbell's
base  salary for 1999 was set at  $212,000  and  $240,000  for  2000);  (ii) the
agreement will automatically  renew for three-year periods thereafter unless the
Company or Dr. Campbell gives 90 days notice of termination;  (iii) Dr. Campbell
is eligible  for a  discretionary  annual  bonus as  determined  by the Board of
Directors,  based upon achieving certain performance criteria;  (iv) the Company
has granted an option to purchase 125,000 shares of Common Stock, exercisable at
a price per share equal to fair market  value on the date of grant,  which stock
option will vest over a four-year period,  (v) the Company has agreed to provide
certain relocation costs and expenses associated with Dr. Campbell's  relocation
from  United  Kingdom  to San Diego,  California;  (vi) in  connection  with the
purchase  of a home  in the San  Diego  area,  the  Company  extended  a loan of
$250,000  bearing annual  interest of 1%; and (vii) Dr.  Campbell is entitled to
continue to receive his salary,  health,  welfare and retirement benefits, a pro
rata share of his annual bonus and vesting of outstanding stock options for nine
months in the event that the Company terminates his employment without cause, or
materially  reduces the power and duties of his employment  without cause, which
will be deemed to be a  termination.  In the event of a change in control of the
Company,  Dr. Campbell would receive the same benefits  package as a termination
without cause,  with the exception that the vesting for all outstanding  options
would be accelerated and immediately exercisable in full.

         Margaret E. Valeur-Jensen, J.D., Ph.D., has an employment contract that
provides  that:  (i) Dr.  Valeur-Jensen  serves  as the  Company's  Senior  Vice
President,  General  Counsel and  Corporate  Secretary for a term of three years
commencing on January 4, 1999 at an initial  annual salary of $212,000,  subject
to annual adjustment by the Board of Directors (Dr.  Valeur-Jensen's base salary
for 2000 was set at $235,000);  (ii) the agreement will automatically  renew for
three-year periods thereafter unless the Company or Dr.  Valeur-Jensen  gives 90
days  notice  of  termination;   (iii)  Dr.  Valeur-Jensen  is  eligible  for  a
discretionary  annual bonus as determined by the Board of Directors,  based upon
achieving certain performance  criteria;  (iv) the Company has granted an option
to purchase  115,000  shares of Common Stock,  exercisable  at a price per share
equal to fair market  value on the date of grant,  which stock  option will vest
over a  four-year  period,  (v)  the  Company  has  agreed  to  provide  certain
relocation costs and expenses associated with Dr. Valeur-Jensen's  relocation to
San Diego,  California;  and (vi) Dr.  Valeur-Jensen  is entitled to continue to
receive her salary, health, welfare and retirement benefits, a pro rata share of
her annual bonus and vesting of outstanding stock options for nine months in the
event that the Company  terminates her employment  without cause,  or materially
reduces  the power and duties of her  employment  without  cause,  which will be
deemed to be a termination.  In the event of a change in control of the Company,
Dr.  Valeur-Jensen  would  receive the same  benefits  package as a  termination
without cause,  with the exception that the vesting for all outstanding  options
would be accelerated and immediately exercisable in full.

<PAGE>

                      REPORT OF THE COMPENSATION COMMITTEE

         The following is a report of the Compensation  Committee of the Company
describing the compensation  policies and rationale  applicable to the Company's
executive  officers  with  respect to the  compensation  paid to such  executive
officers for the year ended December 31, 1999. The information contained in this
report shall not be deemed to be "soliciting material" or to be "filed" with the
SEC nor shall such  information  be  incorporated  by reference  into any future
filing under the Securities  Act or the Exchange Act,  except to the extent that
the Company specifically incorporates it by reference into any such filing.

         The Compensation  Committee (the "Committee") of the Board of Directors
reviews and  recommends  to the Board of Directors  for  approval the  Company's
executive  compensation policies. The Committee is responsible for reviewing the
salary and  benefits  structure  of the Company at least  annually to insure its
competitiveness  within the Company's  industry.  The following is the report of
the Committee describing the compensation  policies and rationales applicable to
the Company's  executive  officers with respect to the compensation paid to such
executive  officers for the fiscal year ended  December 31, 1999.  In 1999,  the
members of the Committee were Joseph A. Mollica, Stephen A. Sherwin and Harry F.
Hixson,  Jr. Harry F. Hixson, Jr. resigned as a member of the Company's Board of
Directors and the Compensation Committee as of December 31, 1999.

COMPENSATION PHILOSOPHY

         The Company's  philosophy in establishing its  compensation  policy for
executive  officers  and other  employees  is to create a structure  designed to
attract  and  retain  highly  skilled  individuals  by  establishing   salaries,
benefits,  and incentive  compensation  which compare  favorably  with those for
similar  positions  in  other  biotechnology  companies.  Compensation  for  the
Company's  executive officers consists of a base salary and potential  incentive
cash bonuses, as well as potential incentive  compensation through stock options
and stock ownership.

BASE SALARY

         The base salary  component of  compensation  is designed to  compensate
executive  officers  competitively  at levels  necessary  to attract  and retain
qualified executives in the pharmaceutical and biotechnology  industry. The base
salaries have been targeted at or above the average rates paid by competitors to
enable the  Company to  attract,  motivate,  reward  and retain  highly  skilled
executives.  In order to  evaluate  the  Company's  competitive  position in the
industry,  the  Committee  reviewed  and  analyzed  the  compensation  packages,
including base salary levels,  offered by other biotechnology and pharmaceutical
companies.  The Company  retained the services of an  independent  consultant to
review and recommend  improvements to the executive compensation policy. Some of
the  competitive  information  was obtained from surveys  prepared by consulting
companies or industry associations (e.g., the Radford Biotechnology Compensation
Survey).  As a general  matter,  the base salary for each  executive  officer is
initially  established  through  negotiation  at the time the  officer  is hired
taking into account such officer's qualifications, experience, prior salary, and
competitive  salary  information.  Year-to-year  adjustments  to each  executive
officer's base salary are based upon personal  performance for the year, changes
in the general level of base salaries of persons in comparable  positions within
the  industry,  and the  average  merit  salary  increase  for such year for all
employees of the Company established by the Compensation  Committee,  as well as
other  factors  the  Compensation  Committee  judges to be  pertinent  during an
assessment period. In making base salary decisions,  the Committee exercises its
judgment  to  determine  the  appropriate  weight  to be  given to each of these
factors.

<PAGE>

ANNUAL INCENTIVE COMPENSATION

         A portion  of the cash  compensation  paid to the  Company's  executive
officers, including the Chief Executive Officer, is in the form of discretionary
bonus  payments  that  are  paid on an  annual  basis  as part of the  Company's
Incentive  Compensation  Plan.  Bonus  payments are linked to the  attainment of
overall  corporate  goals  established  by the Board of Directors and individual
goals  established for each executive  officer.  The maximum potential amount of
each officer's  bonus payment is established  annually by the Board of Directors
based upon the  recommendation  of the Committee.  The appropriate  weight to be
given  to  each of the  various  goals  used to  calculate  the  amount  of each
officer's  bonus  payment  is  determined  by the  Committee.  The  goal  of the
Company's  Incentive  Compensation Plan is to support the achievement of Company
goals and objectives by basing compensation on a pay for performance basis.

LONG-TERM INCENTIVES

         The Committee provides the Company's  executive officers with long-term
incentive  compensation  through  grants of stock options under the Plan and the
opportunity  to purchase  stock under the ESPP.  The Board  believes  that stock
options  provide  the  Company's  executive  officers  with the  opportunity  to
purchase  and  maintain  an equity  interest  in the Company and to share in the
appreciation of the value of the Company's Common Stock. The Board believes that
stock options directly motivate an executive to maximize  long-term  shareholder
value.  The options also utilize  vesting  periods  (generally  four years) that
encourage  key  executives  to continue in the employ of the Company.  The Board
considers the grant of each option subjectively, considering factors such as the
individual performance of the executive officer and the anticipated contribution
of the executive officer to the attainment of the Company's  long-term strategic
performance  goals.  Long-term  incentives granted in prior years are also taken
into consideration.

         The  Company  established  the  ESPP  both to  encourage  employees  to
continue  in  the  employ  of the  Company  and to  motivate  employees  through
ownership  interest  in  the  Company.  Under  the  ESPP,  employees,  including
officers,  may have up to 15% of their earnings withheld for purchases of Common
Stock on  certain  dates  specified  by the  Board.  The price of  Common  Stock
purchased  will be equal to 85% of the  lower  of the fair  market  value of the
Common Stock on the date of enrollment or exercise date, whichever is lower.

CHIEF EXECUTIVE OFFICER COMPENSATION

         The compensation of the Chief Executive Officer is reviewed annually on
the same basis as discussed  above for all  executive  officers.  Gary A. Lyons'
base salary for 1998 was $328,300 until March 1, 1998, when it became  $346,375.
Mr.  Lyons' base salary for 1999 was set at $365,000 and $385,000 for 2000.  Mr.
Lyons joined the Company in February 1993. His initial salary,  potential bonus,
and stock grants were  determined on the basis of negotiation  between the Board
of Directors and Mr. Lyons with due regard for his  qualifications,  experience,
prior salary,  and competitive  salary  information.  Mr. Lyons' base salary for
1999 was  established in part by comparing the base salaries of chief  executive
officers at other  biotechnology and  pharmaceutical  companies of similar size.
Mr. Lyons earned a $100,000  bonus for 1999. As with other  executive  officers,
Mr. Lyons' total compensation was based on the Company's accomplishments and the
Chief Executive Officer's contribution thereto.

<PAGE>

SECTION 162(M)

         The Board has considered the potential future effects of Section 162(m)
of the  Code on the  compensation  paid  to the  Company's  executive  officers.
Section 162(m) disallows a tax deduction for any  publicly-held  corporation for
individual  compensation  exceeding  $1.0 million in any taxable year for any of
the executive  officers named in the proxy  statement,  unless  compensation  is
performance-based.  The  Company  has adopted a policy  that,  where  reasonably
practicable,  the Company will seek to qualify the variable compensation paid to
its executive  officers for an exemption from the  deductibility  limitations of
Section 162(m).

         In  approving  the amount and form of  compensation  for the  Company's
executive officers,  the Committee will continue to consider all elements of the
cost to the Company of providing  such  compensation,  including  the  potential
impact of Section 162(m).

                                     Respectfully submitted by:

                                     COMPENSATION COMMITTEE


                                     Joseph A. Mollica
                                     Stephen A. Sherwin



COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION

         As of December 31, 1999, the Compensation Committee consisted of Joseph
A. Mollica,  Stephen A. Sherwin and Harry F. Hixson,  Jr. Effective December 31,
1999,  Harry F. Hixson,  Jr.  resigned from the Company's Board of Directors and
the  Compensation  Committee  and has  not  been  replaced  . No  member  of the
Compensation  Committee has a relationship that would constitute an interlocking
relationship with executive officers or directors of another entity.

CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

         In March 1993,  the Company loaned to Gary A. Lyons,  President,  Chief
Executive Officer and Director of the Company, $85,500 for the purchase of stock
in the Company. Pursuant to Mr. Lyons' Employment Agreement dated March 1, 1997,
the loan bears interest at a rate of 4% per annum and is due and payable in full
upon  receipt of proceeds  from the sale of  Neurocrine  Common Stock or 90 days
after voluntary termination. As of the record date, $85,500 remained outstanding
on the loan.  In  December  1993,  the  Company  loaned Mr.  Lyons  $135,000  in
connection with certain housing  relocation  expenses.  One half of the loan had
been forgiven as of February 1997; pursuant to Mr. Lyons' Employment  Agreement,
the remaining  half of the loan bears interest at a rate of 6% per annum and was
forgiven  over a  three-year  period  starting  on March  1,  1997,  subject  to
repayment  in the event of  termination  of  employment.  As of the record date,
there was no remaining balance on the loan.

         In March 1993,  the Company  loaned to Paul W. Hawran,  Executive  Vice
President  of the  Company,  $15,000 for the  purchase of stock in the  Company.
Pursuant to Mr.  Hawran's  Employment  Agreement  dated March 1, 1997,  the loan
bears  interest  at a rate of 4% per annum and is due and  payable  in full upon
receipt of proceeds  from the sale of  Neurocrine  Common Stock or 90 days after
voluntary  termination.  As of the record date, $15,000 remained  outstanding on
the loan.  In June 1994,  the Company  loaned  Paul W.  Hawran,  Executive  Vice
President  of the  Company,  $175,000 in  connection  with  certain  housing and
relocation expenses. One half of the loan had been forgiven as of February 1997;
pursuant to the Employment  Agreement dated March 1, 1997, the remaining half of
the loan  bears  interest  at a rate of 6% per  annum  and was  forgiven  over a
three-year  period starting on March 1, 1997,  subject to repayment in the event
of  termination  of  employment.  As of the record date,  there was no remaining
balance on the loan.

<PAGE>

         In February 1998, the Company loaned D. Bruce Campbell,  Ph.D.,  Senior
Vice President,  Development of the Company, $250,000 in connection with certain
housing and  relocation  expenses.  The principal  balance of the loan will bear
interest  at a rate of one  percent  per annum  (1.0%  p.a.) and  principal  and
interest  will be payable upon the first to occur of (i) sale of the home,  (ii)
six (6) months  following  voluntary or  involuntary  termination of Executive's
employment with the Company,  (iii) the exercise,  pledge or sale of all or part
of the stock options  granted by Company to Executive or (iv) December 31, 1999.
As of December 31, 1999,  $74,854 remained  outstanding on the loan. The parties
agree that the remaining balance will be forgiven under certain circumstances.

         Dr.  Wylie Vale,  a Director  of the  Company,  is a Professor  and the
Senior Investigator and Head of the Clayton Foundation  Laboratories for Peptide
Biology at The Salk  Institute.  In 1999, the Company paid $84,206,  to The Salk
Institute in connection with various license agreements.

         The Company has a consulting agreement with Dr. Vale, pursuant to which
Dr.  Vale  spends a  significant  amount  of time  performing  services  for the
Company,  including  attendance at meetings of the Company's Scientific Advisory
Board, and is prohibited from providing  consulting services to or participating
in the formation of any company in Neurocrine's field of interest or that may be
competitive  with  Neurocrine.  Dr. Vale's agreement is for a one-year term that
commenced in August 1999 and provides for an annual  consulting  fee of $100,000
in exchange for his consulting  services to the Company.  This agreement  allows
annual renewals at the options of both parties.

         In November 1999, the Company signed a 3-year consulting agreement with
Dr.  Stephen  A.  Sherwin.  Under the terms of the  agreement,  Dr.  Sherwin  is
consulting on the Company's regulatory strategy, planning and implementation. He
is also a member of the Company's Clinical Advisory Board and will advise on all
clinical and preclinical programs. In exchange for his services, Dr. Sherwin was
granted an option to purchase 15,000 shares of the Company's Common Stock.  This
option will vest over a 3-year term based on continued services.

         During  fiscal  1999,  there  were no other  transactions  between  the
Company and its Directors,  executive officers, or known holders of greater than
five percent of the Company's Common Stock in which the amount involved exceeded
$60,000  and in which any of the  foregoing  persons had or will have a material
interest.



                                  OTHER MATTERS

         As of the date of this Proxy  Statement,  the Company knows of no other
matters to be submitted  to the  meeting.  If any other  matters  properly  come
before the meeting,  it is the  intention  of the persons  named in the enclosed
proxy card to vote the  shares  they  represent  as the Board of  Directors  may
recommend.

BY ORDER OF THE BOARD OF DIRECTORS

San Diego, California
Dated:  April 27, 2000

<PAGE>


This Proxy is solicited on behalf of the Board of Directors


                          NEUROCRINE BIOSCIENCES, INC.

                       2000 ANNUAL MEETING OF STOCKHOLDERS

                             TO BE HELD May 24, 2000



         The undersigned stockholder of NEUROCRINE BIOSCIENCES, INC., a Delaware
corporation,  hereby  acknowledges  receipt of the  Notice of Annual  Meeting of
Stockholders and Proxy Statement,  each dated April 27, 2000 and hereby appoints
Gary  A.   Lyons  and  Paul  W.   Hawran,   and  each  of  them,   proxies   and
attorneys-in-fact, with full power to each of substitution, on behalf and in the
name of the undersigned, to represent the undersigned at the 2000 Annual Meeting
of  Stockholders of NEUROCRINE  BIOSCIENCES,  INC. to be held on May 24, 2000 at
8:30 a.m. local time, at the Company's corporate  headquarters  located at 10555
Science Center Drive,  San Diego,  California,  92121, and at any adjournment or
adjournments  thereof,  and to  vote  all  shares  of  Common  Stock  which  the
undersigned would be entitled to vote if then and there personally  present,  on
the matters set forth below:

1.       ELECTION OF DIRECTORS:

         For all nominees listed below        Against all nominees listed below
         (except as indicated)

         If you wish to withhold  authority to vote for any individual  nominee,
         strike a line through that nominee's name in the list below:

                       Wylie W. Vale and Joseph A. Mollica


2.       PROPOSAL TO INCREASE THE NUMBER OF SHARES OF COMMON STOCK  RESERVED FOR
         ISSUANCE UNDER THE 1992 INCENTIVE  STOCK PLAN FROM 5,300,000  SHARES TO
         6,050,000 SHARES:

          For                       Against                    Abstain


3.       PROPOSAL TO INCREASE THE NUMBER OF SHARES OF COMMON STOCK  RESERVED FOR
         ISSUANCE  UNDER THE 1996  EMPLOYEE  STOCK  PURCHASE  PLAN FROM  125,000
         SHARES TO 425,000 SHARES:

         For                       Against                    Abstain


4.       PROPOSAL TO INCREASE THE NUMBER OF SHARES OF COMMON STOCK  RESERVED FOR
         ISSUANCE  UNDER THE 1996  DIRECTORS PLAN FROM 200,000 SHARES TO 300,000
         SHARES:

         For                       Against                    Abstain

5.       PROPOSAL  TO  RATIFY  THE  APPOINTMENT  OF  ERNST  &  YOUNG  LLP AS THE
         INDEPENDENT  AUDITORS  OF THE  COMPANY  FOR THE  FISCAL  PERIOD  ENDING
         DECEMBER 31, 2000:

         For                       Against                    Abstain

and, in their  discretion,  upon such other matter or matters which may properly
come before the meeting or any adjournment or adjournments thereof.

<PAGE>

THIS PROXY WILL BE VOTED AS DIRECTED OR, IF NO CONTRARY  DIRECTION IS INDICATED,
WILL BE VOTED FOR THE ELECTION OF THE DIRECTORS  NAMED ABOVE,  FOR THE AMENDMENT
OF THE 1992  INCENTIVE  STOCK PLAN, FOR THE AMENDMENT OF THE 1996 EMPLOYEE STOCK
PURCHASE  PLAN,  FOR  THE  AMENDMENT  OF THE  1996  DIRECTORS  PLAN  AND FOR THE
RATIFICATION OF THE APPOINTMENT OF ERNST & YOUNG LLP AS INDEPENDENT AUDITORS AND
AS SAID PROXIES DEEM ADVISABLE ON SUCH OTHER MATTERS AS MAY PROPERLY COME BEFORE
THE MEETING.

- - - - --------------------------------                  -------------------
Signature                                         Date


- - - - --------------------------------                  -------------------
Signature                                         Date


(This Proxy should be marked, dated and signed by the stockholder(s)  exactly as
his or her name appears hereon,  and returned promptly in the enclosed envelope.
Persons signing in a fiduciary  capacity should so indicate.  If shares are held
by joint tenants or as community property, both should sign.)



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