LEUKOSITE INC
SC 13D, 1997-09-03
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934


                                 LEUKOSITE, INC.
                                (Name of Issuer)

                                  COMMON STOCK
                                 $.01 PAR VALUE
                         (Title of Class of Securities)


                                   52728R 10 2
                                 (CUSIP Number)

                                 Kevin S. Moore
                                 Vice President
                            Eighth Floor Corporation
                                   Ninth Floor
                                 30 Wall Street
                            New York, New York 10005
                            Tel. No.: (212) 269-1833

                                 With a copy to:

                          William M. Evarts, Jr., Esq.
                       Winthrop, Stimson, Putnam & Roberts
                             One Battery Park Plaza
                          New York, New York 10004-1490
                                 (212) 858-1201
                     (Name, Address and Telephone Number of
                      Person Authorized to Receive Notices
                               and Communications)

                                 August 20, 1997
                          (Date of Event which Requires
                            Filing of this Statement)

     If the filing  person has  previously  filed a statement on Schedule 13G to
report the acquisition  which is the subject of this Schedule 13D, and is filing
this statement because of Rule 13d-1(b)(3) or (4), check the following: [ ]



<PAGE>
                                  SCHEDULE 13D

- --------------------------------------------------------------------------------
CUSIP NO. 52728R 10 2                                         Page 2 of 8 Pages

- --------------------------------------------------------------------------------
  1  NAME OF REPORTING PERSON
     S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

          I.S. Partners, L.P.
- --------------------------------------------------------------------------------
  2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                 (a)   |_|
                                                                       (b)   |_|
- --------------------------------------------------------------------------------
  3  SEC USE ONLY
- --------------------------------------------------------------------------------
  4  SOURCE OF FUNDS*

          OO
- --------------------------------------------------------------------------------
  5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
     ITEMS 2(d) OR 2(e)                            |_|
- --------------------------------------------------------------------------------
  6  CITIZENSHIP OR PLACE OF ORGANIZATION

         New York
- --------------------------------------------------------------------------------

 NUMBER OF SHARES           7  SOLE VOTING POWER
BENEFICIALLY OWNED                  736,873
 BY EACH REPORTING        -----------------------------------------------------
    PERSON WITH             8  SHARED VOTING POWER
                                     0
                          ------------------------------------------------------
                            9  SOLE DISPOSITIVE POWER
                                     736,873
                          ------------------------------------------------------
                           10  SHARED DISPOSITIVE POWER
                                     0
- --------------------------------------------------------------------------------
 11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

          736,873 shares
- --------------------------------------------------------------------------------
 12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES   |_|
- --------------------------------------------------------------------------------
 13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

          8.1%
- --------------------------------------------------------------------------------
 14  TYPE OF REPORTING PERSON*

          PN
- --------------------------------------------------------------------------------


<PAGE>

Item 1. Security and Issuer.

     This Statement  relates to shares of Common Stock, $.01 par value per share
(the "Common Stock") of Leukosite, Inc., a Delaware corporation (the "Company").
The address of the Company's  principal  executive  offices is 215 First Street,
Cambridge, MA 02142.

Item 2. Identity and Background.

     (a) - (c)  This  Statement  is  being  filed by I.S.  Partners,  Inc.  (the
"Reporting Person").

     The  Reporting  Person is a New York limited  partnership  whose  principal
business is to acquire,  hold,  manage,  trade, sell,  exchange,  dispose of and
otherwise  profit  from  investments  for its own account and to engage in other
lawful activities  incidental thereto as the General Partner (as defined herein)
shall determine from time to time. The business  address of the Reporting Person
is Ninth Floor, 30 Wall Street, New York, New York 10005.

     The name, business address,  present principal  occupation or employment of
the general  partner (the "General  Partner") of the  Reporting  Person and each
person  controlling  such General Partner (the  "Shareholder")  are set forth in
Schedule I hereto,  which is incorporated herein by reference.  

     (d) - (e) During the last five years,  neither the Reporting Person nor, to
the  best  knowledge  of the  Reporting  Person,  the  General  Partner  nor the
Shareholder has (A) been convicted in a criminal  proceeding  (excluding traffic
violations or similar misdemeanors) or (B) been a party to a civil proceeding of
a judicial or administrative  body of competent  jurisdiction and as a result of
such proceeding was or is subject to a judgment, decree or final order enjoining

<PAGE>

future violations of, or prohibiting or mandating activities subject to, federal
or state securities laws or finding any violation with respect to such laws.

     (f) Each of the  persons  listed in this Item 2 or  Schedule  I hereto is a
citizen of the United States of America.

Item 3. Source and Amount of Funds or Other Consideration.

                  On November 5, 1993, the Reporting Person purchased  1,250,000
shares of the Company's  Series A Convertible  Preferred  Stock ("Series A"). On
June 9, 1994, the Reporting Person  purchased an additional  1,250,000 of Series
A. The aggregate  purchase price for such Series A was $2,250,000.  On September
13, 1994, the Reporting Person purchased  166,667 shares of the Company's Series
B Convertible  Preferred Stock ("Series B") for $200,000. On September 12, 1995,
the  Reporting  Person  purchased  315,767  shares  of the  Company's  Series  D
Convertible Preferred Stock ("Series D") for $426,286. On February 29, 1996, the
Reporting  Person  purchased 18,519 shares of the Company's Series F Convertible
Preferred Stock ("Series F" and,  together with Series A, Series B and Series D,
the  "Preferred  Stock").  On June 17, 1996, the Reporting  Person  purchased an
additional  14,815  shares of Series F. The  aggregate  purchase  price for such
Series F was $100,000.  The aggregate purchase price for the Preferred Stock was
funded from capital  contributions by the partners of the Reporting  Person.  

     On August 20, 1997, the Company  consummated an initial public  offering of
2,500,000 shares of Common Stock (the "Offering"). Concurrently with the closing
of the Offering,  the shares of Preferred  Stock held by the  Reporting  Company
were  automatically  converted  into  736,873  shares  of  Common  Stock,  which
constitutes approximately 8.1% of the outstanding shares of Common Stock.


<PAGE>

Item 4. Purpose of Transaction.

     All of the shares of Common Stock were  acquired for  investment  purposes.
The Reporting  Person currently does not have any plans or proposals of the type
set forth in Paragraphs  (a) through (j) of Item 4 of Schedule 13D. Any decision
of the Reporting Person either to purchase  additional shares of Common Stock or
to  dispose  of any of such  shares  will take  into  account  various  factors,
including general economic conditions and money and stock market conditions.

Item 5. Interest in Securities of the Issuer.

     (a) The 736,873 shares of Common Stock  beneficially owned by the Reporting
Person constitute  approximately  8.1% of the outstanding shares of Common Stock
(based upon an aggregate of 9,150,480  outstanding  shares of Common Stock as of
August 20, 1997 and after giving effect to the conversion of the Preferred Stock
on August 20, 1997).  

     (b) The Reporting  Person,  by the action of its General Partner,  has sole
power to vote or to direct the vote of the shares of Common Stock referred to in
paragraph (a) above and sole power to dispose of or to direct the disposition of
any such shares. As a result,  the General Partner may be deemed to beneficially
own the shares of Common Stock  beneficially owned by the Reporting Person. As a
shareholder  of the  General  Partner,  the  Shareholder  may also be  deemed to
beneficially own the shares of Common Stock  beneficially owned by the Reporting
Person.


<PAGE>

     (c) Except as set forth herein,  neither the Reporting Person,  the General
Partner nor the  Shareholder  has effected any  transaction  in shares of Common
Stock during the past sixty days.

     (d) No person other than the  Reporting  Person has the right to receive or
the power to direct the receipt of dividends from, or the proceeds from the sale
of, the shares of Common Stock which are the subject of this report.

     (e) Not applicable

Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to
Securities of the Issuer.

     The Company and the Reporting  Person and certain other  stockholders  (the
"Stockholders") are parties to the Amended and Restated Stockholders'  Agreement
dated December 20, 1996 (the "Stockholders'  Agreement").  Pursuant to the terms
of the Stockholders' Agreement, the Stockholders are entitled to certain demands
and registration rights of the Common Stock,  including  piggyback  registration
rights  and  Form  S-3  registration  rights.  In  addition,  the  Stockholders'
Agreement contains  provisions for a lock-up period of 180 days after August 15,
1997  during  which time  there are  restrictions  on the  offer,  sale or other
disposition  of any  restricted  shares  without  the prior  written  consent of
Hambrecht & Quist LLC.

     Except for the  Stockholders'  Agreement  referred  to above,  neither  the
Reporting  Person,  nor (to the best  knowledge  of the  Reporting  Person)  the
General   Partner  nor  the   Shareholder,   has  any   contract,   arrangement,
understanding or relationship  (legal or otherwise) with any person with respect
to any  securities of the Company,  including but not limited to the transfer or
voting of any of such securities,  finder's fees, joint ventures, loan or option
arrangements,  puts or calls, guarantees of profits, division of profits or loss
or the giving or the withholding of proxies.



<PAGE>

Item 7. Material to be Filed as Exhibits.

     Stockholders'  Agreement (incorporated by reference to Exhibit 10.26 to the
Company's Registration Statement on Form S-1 (No. 333-30213)).


<PAGE>




                                   SIGNATURES


     After  reasonable  inquiry and to the best knowledge and belief,  I certify
that the information set forth in this statement is true, complete and correct.


September 2, 1997
- -----------------
Date


I.S. Partners, L.P.

By:  Eighth Floor Corporation



By: /s/ Kevin S. Moore
   ---------------------------
   Name:   Kevin S. Moore
   Title:  Vice President



<PAGE>


                                   SCHEDULE I


     Except  where  otherwise  indicated,  the  business  address of each of the
following Ninth Floor, 30 Wall Street, New York, New York 10005.



Name                                        Principal Occupation
- ----                                        and Name of Business
                                            --------------------

Eighth Floor Corporation,                   General Partner
a privately held  Delaware corporation      I.S. Partners, L.P.

Martin H. Peretz                            The New Republic
                                            Editor-in-Chief



<PAGE>


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