LEUKOSITE INC
SC 13D/A, 1998-05-08
PHARMACEUTICAL PREPARATIONS
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                                  UNITED STATES
                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D

                    Under the Securities Exchange Act of 1934

                                (Amendment No. 1)


                                 LEUKOSITE, INC.
                                (Name of Issuer)

                                  COMMON STOCK
                                 $.01 PAR VALUE
                         (Title of Class of Securities)

                                    52728R102
                                 (CUSIP Number)

                                 Kevin S. Moore
                Senior Vice President and Chief Financial Officer
                             The Clark Estates, Inc.
                               Thirty-First Floor
                              One Rockefeller Plaza
                            New York, New York 10020
                            Tel. No.: (212) 269-1833

                                 With a copy to:

                             David W. Ambrosia, Esq.
                       Winthrop, Stimson, Putnam & Roberts
                             One Battery Park Plaza
                          New York, New York 10004-1490
                                 (212) 858-1208
                     (Name, Address and Telephone Number of
                      Person Authorized to Receive Notices
                               and Communications)

                                 April 23, 1998
                          (Date of Event which Requires
                            Filing of this Statement)

     If the filing  person has  previously  filed a statement on Schedule 13G to
report the acquisition  which is the subject of this Schedule 13D, and is filing
this statement because of Rule 13d-1(b)(3) or (4), check the following: [ ]



<PAGE>




                                  SCHEDULE 13D

================================================================================
CUSIP NO.52728R102                                           Page 2 of 7 Pages

================================================================================
 1  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON

         I.S. Partners, L.P.
         13-5524538
================================================================================
 2  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*                  (a) [ ]
                                                                       (b) [ ]
================================================================================
 3  SEC USE ONLY
================================================================================
 4  SOURCE OF FUNDS*

         Not Applicable
================================================================================
 5  CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO 
    ITEMS 2(d) OR 2(e)                                                     [ ]
================================================================================
 6  CITIZENSHIP OR PLACE OF ORGANIZATION

         New York
================================================================================
                                   7  SOLE VOTING POWER

     NUMBER OF SHARES                      0
  BENEFICIALLY OWNED BY
EACH REPORTING PERSON WITH
                            ====================================================
                                   8  SHARED VOTING POWER

                                           0
                            ====================================================
                                   9  SOLE DISPOSITIVE POWER

                                           0
                            ====================================================
                                  10  SHARED DISPOSITIVE POWER

                                           0
================================================================================
11  AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

         0
================================================================================
12  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES  [ ]
================================================================================
13  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (11)

         0%
================================================================================
14  TYPE OF REPORTING PERSON*

         PN
================================================================================


<PAGE>
                                  SCHEDULE 13D

     Pursuant to Item  101(a)(2)(ii)  of Regulation S-T promulgated  pursuant to
the Securities  Exchange Act of 1934, as amended (the "Act"), this Amendment No.
1 restates the Schedule 13D dated  September 3, 1997 filed by The Clark Estates,
Inc. (as amended, the "Schedule 13D").

Item 1. Security and Issuer.

     This  Statement  relates  to shares of Common  Stock,  $.01 par value  (the
"Common Stock"), of Leukosite, Inc., a Delaware corporation (the "Company"). The
address  of the  Company's  principal  executive  office  is 215  First  Street,
Cambridge, Massachusetts 02142.

Item 2. Identity and Background.

     (a) - (c)  This  statement  is  being  filed by I.S.  Partners,  Inc.  (the
"Reporting Person"). The information below in this Item 2 updates, to the extent
necessary, the information included in the Reporting Person's prior Schedule 13D
filings with respect to the Company.

     The  Reporting  Person is a New York limited  partnership  whose  principal
business is to acquire,  hold,  manage,  trade, sell,  exchange,  dispose of and
otherwise  profit  from  investments  for its own account and to engage in other
lawful activities  incidental thereto as the General Partner (as defined herein)
shall determine from time to time. The business  address of the Reporting Person
is Thirty-First Floor, One Rockefeller Plaza, New York, New York 10020.


<PAGE>

     The name, business address,  present principal  occupation or employment of
the general  partner (the "General  Partner") of the  Reporting  Person and each
person  controlling  such General Partner (the  "Shareholder")  are set forth in
Schedule I hereto, which is incorporated herein by reference.

     (d) - (e) During the last five years,  neither the Reporting Person nor, to
the  best  knowledge  of the  Reporting  Person,  the  General  Partner  nor the
Shareholder has (A) been convicted in a criminal  proceeding  (excluding traffic
violations or similar misdemeanors) or (B) been a party to a civil proceeding of
a judicial or administrative  body of competent  jurisdiction and as a result of
such proceeding was or is subject to a judgment, decree or final order enjoining
future violations of, or prohibiting or mandating activities subject to, federal
or state securities laws or finding any violation with respect to such laws.

     (f) Each of the  persons  listed in this Item 2 or  Schedule  I hereto is a
citizen of the United States of America.

Item 3. Source and Amount of Funds or Other Consideration.

     Not Applicable.

Item 4. Purpose of Transaction.

     The purpose of the Reporting  Person's  distribution  of the Company Common
Stock to the  partners  of the  Reporting  Person was to  dissolve  the  limited
partnership.

Item 5. Interest in Securities of the Issuer.

     (a) The 736,873 shares of Common Stock  beneficially owned by the Reporting
Person constituted  approximately 7.5% of the outstanding shares of Common Stock
(based upon an aggregated of 9,884,860  outstanding shares of Common Stock as of
March 18, 1998 as reported in the Company's  Form 10-K for the fiscal year ended
December 31, 1997). As a result of the  transactions  described in paragraph (c)
of this Item 5, the Reporting Person no longer  beneficially  owns any shares of
Common Stock of the Company.


<PAGE>

     (b) Not Applicable.

     (c) On April 23, 1998, the Reporting Person  distributed all 736,873 shares
of Common  Stock of the  Company  that it  beneficially  owned to the  Reporting
Person's partners.

     (d) Not applicable.

     (e) As of April 23, 1998 the Reporting  Person ceased to be the  beneficial
owner of more than 5% of the  outstanding  shares of Company  Common  Stock as a
result of the  distribution  of Company  Common  Stock by the  Reporting  Person
described above in this Item 5.

Item 6. Contracts, Arrangements, Understandings or Relationships With Respect to
        Securities of the Issuer.

     Not applicable.

Item 7. Material to be Filed as Exhibits.

     Not applicable.


<PAGE>

                                   SIGNATURES


                  After reasonable inquiry and to the best knowledge and belief,
I certify that the information set forth in this statement is true, complete and
correct.


May 8, 1998
- -----------
Date


I.S. Partners, L.P.

By:  Eighth Floor Corporation


Signature

/s/ Kevin S. Moore
- ---------------------
Kevin S. Moore
Vice President
Name/Title



<PAGE>


                                   SCHEDULE I


     Except  where  otherwise  indicated,  the  business  address of each of the
following is I.S. Partners, L.P., Thirty-First Floor, One Rockefeller Plaza, New
York, New York 10020.

                                                   Principal Occupation
Name                                               and Name of Business
- ----                                               --------------------
Eighth Floor Corporation,                          General Partner
a privately held Delaware corporation              I.S. Partners, L.P.


Martin H. Peretz                                   The New Republic
                                                   Editor-in-Chief


<PAGE>


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