LEUKOSITE INC
SC 13G, 1999-02-16
PHARMACEUTICAL PREPARATIONS
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<PAGE>

                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                  SCHEDULE 13G
                                 (Rule 13d-102)

                    INFORMATION TO BE INCLUDED IN STATEMENTS
                FILED PURSUANT TO RULES 13d-1(b), (c) AND (d) AND
               AMENDMENTS THERETO FILED PURSUANT TO RULE 13d-2(b)
                                (Amendment No. 2)(1)



                                LEUKOSITE, INC. 
- --------------------------------------------------------------------------------
                                (Name of Issuer)

                           Common Stock $.01 par value
- --------------------------------------------------------------------------------
                         (Title of Class of Securities)

                                    52728R102
- --------------------------------------------------------------------------------
                                 (CUSIP Number)

                                December 31, 1998
- --------------------------------------------------------------------------------
             (Date of Event Which Requires Filing of this Statement)


Check the appropriate box to designate the rule pursuant to which this Schedule
is filed:

       [ ]  Rule 13d-1 (b)

       [ ]  Rule 13d-1 (c)

       [X]  Rule 13d-1 (d)

- ----------
(1) The remainder of this cover page shall be filled out for a reporting
person's initial filing on this form with respect to the subject class of
securities, and for any subsequent amendment containing information which would
alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the Securities Exchange Act of
1934 ("Act") or otherwise subject to the liabilities of that section of the Act
but shall be subject to all other provisions of the Act (however, see the
Notes).

                        (Continued on following page(s))
                               Page 1 of 20 Pages


<PAGE>
- -------------------------------                    -----------------------------
CUSIP NO.    52728R102                13G                 Page 2 of 20 Pages
          ---------------                                                       
- -------------------------------                    -----------------------------

- --------------------------------------------------------------------------------
   1       NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON

           HealthCare Ventures III, L.P.
- --------------------------------------------------------------------------------
   2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  [ ]
                                                                       (b)  [ ]
           
- --------------------------------------------------------------------------------
   3       SEC USE ONLY


- --------------------------------------------------------------------------------
   4       CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER
                                    
    
                            ----------------------------------------------------
           NUMBER OF         6    SHARED VOTING POWER
            SHARES    
         BENEFICIALLY             1,545,944
           OWNED BY   
             EACH           ----------------------------------------------------
           REPORTING         7    SOLE DISPOSITIVE POWER
            PERSON                         
             WITH                                
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER
                                 
                                  1,545,944
- --------------------------------------------------------------------------------
   9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,545,944
- --------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES*  
                                                                            [ ]
- --------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           13%
- --------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           PN
- --------------------------------------------------------------------------------
                      * SEE INSTRUCTION BEFORE FILLING OUT!
   
                                       
<PAGE>

- -------------------------------                    -----------------------------
CUSIP NO.    52728R102                13G                 Page 3 of 20 Pages
          ---------------                                                       
- -------------------------------                    -----------------------------

- --------------------------------------------------------------------------------
   1       NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON

           HealthCare Partners III, L.P.
- --------------------------------------------------------------------------------
   2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  [ ]
                                                                       (b)  [ ]
           
- --------------------------------------------------------------------------------
   3       SEC USE ONLY


- --------------------------------------------------------------------------------
   4       CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER
                                    
    
                            ----------------------------------------------------
           NUMBER OF         6    SHARED VOTING POWER
            SHARES    
         BENEFICIALLY             1,545,944
           OWNED BY   
             EACH           ----------------------------------------------------
           REPORTING         7    SOLE DISPOSITIVE POWER
            PERSON                         
             WITH                                
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER
                                   
                                  1,545,944
- --------------------------------------------------------------------------------
   9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           1,545,944
- --------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES*  
                                                                            [ ]
- --------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           13%
- --------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           PN
- --------------------------------------------------------------------------------
                      * SEE INSTRUCTION BEFORE FILLING OUT!

                                      
<PAGE>
- -------------------------------                    -----------------------------
CUSIP NO.    52728R102                13G                 Page 4 of 20 Pages
          ---------------                                                       
- -------------------------------                    -----------------------------

- --------------------------------------------------------------------------------
   1       NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON

           HealthCare Ventures IV, L.P.
- --------------------------------------------------------------------------------
   2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  [ ]
                                                                       (b)  [ ]
           
- --------------------------------------------------------------------------------
   3       SEC USE ONLY


- --------------------------------------------------------------------------------
   4       CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER
                                    
    
                            ----------------------------------------------------
           NUMBER OF         6    SHARED VOTING POWER
            SHARES    
         BENEFICIALLY             453,982
           OWNED BY   
             EACH           ----------------------------------------------------
           REPORTING         7    SOLE DISPOSITIVE POWER
            PERSON                         
             WITH                                
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER
                                   
                                  453,982
- --------------------------------------------------------------------------------
   9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           453,982
- --------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES*  
                                                                            [ ]
- --------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           .03%
- --------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           PN
- --------------------------------------------------------------------------------
                      * SEE INSTRUCTION BEFORE FILLING OUT!

                                      
<PAGE>
- -------------------------------                    -----------------------------
CUSIP NO.    52728R102                13G                 Page 5 of 20 Pages
          ---------------                                                       
- -------------------------------                    -----------------------------

- --------------------------------------------------------------------------------
   1       NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON

           HealthCare Partners IV, L.P.
- --------------------------------------------------------------------------------
   2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  [ ]
                                                                       (b)  [ ]
           
- --------------------------------------------------------------------------------
   3       SEC USE ONLY


- --------------------------------------------------------------------------------
   4       CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER
                                    
    
                            ----------------------------------------------------
           NUMBER OF         6    SHARED VOTING POWER
            SHARES    
         BENEFICIALLY             453,982
           OWNED BY   
             EACH           ----------------------------------------------------
           REPORTING         7    SOLE DISPOSITIVE POWER
            PERSON                         
             WITH                                
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER
                                   
                                  453,982
- --------------------------------------------------------------------------------
   9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           453,982
- --------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES*  
                                                                            [ ]
- --------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           .03%
- --------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           PN
- --------------------------------------------------------------------------------
                      * SEE INSTRUCTION BEFORE FILLING OUT!

                                      
<PAGE>
- -------------------------------                    -----------------------------
CUSIP NO.    52728R102                13G                 Page 6 of 20 Pages
          ---------------                                                       
- -------------------------------                    -----------------------------

- --------------------------------------------------------------------------------
   1       NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON

           HealthCare Ventures V, L.P.
- --------------------------------------------------------------------------------
   2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  [ ]
                                                                       (b)  [ ]
           
- --------------------------------------------------------------------------------
   3       SEC USE ONLY


- --------------------------------------------------------------------------------
   4       CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER
                                    
    
                            ----------------------------------------------------
           NUMBER OF         6    SHARED VOTING POWER
            SHARES    
         BENEFICIALLY             479,167
           OWNED BY   
             EACH           ----------------------------------------------------
           REPORTING         7    SOLE DISPOSITIVE POWER
            PERSON                         
             WITH                                
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER
                                   
                                  479,167
- --------------------------------------------------------------------------------
   9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           479,167
- --------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES*  
                                                                            [ ]
- --------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           .04%
- --------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           PN
- --------------------------------------------------------------------------------
                      * SEE INSTRUCTION BEFORE FILLING OUT!

                                      
<PAGE>
- -------------------------------                    -----------------------------
CUSIP NO.    52728R102                13G                 Page 7 of 20 Pages
          ---------------                                                       
- -------------------------------                    -----------------------------

- --------------------------------------------------------------------------------
   1       NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON

           HealthCare Partners V, L.P.
- --------------------------------------------------------------------------------
   2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  [ ]
                                                                       (b)  [ ]
           
- --------------------------------------------------------------------------------
   3       SEC USE ONLY


- --------------------------------------------------------------------------------
   4       CITIZENSHIP OR PLACE OF ORGANIZATION

           Delaware
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER
                                    
    
                            ----------------------------------------------------
           NUMBER OF         6    SHARED VOTING POWER
            SHARES    
         BENEFICIALLY             479,167
           OWNED BY   
             EACH           ----------------------------------------------------
           REPORTING         7    SOLE DISPOSITIVE POWER
            PERSON                         
             WITH                                
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER
                                   
                                  479,167
- --------------------------------------------------------------------------------
   9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           479,167
- --------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES*  
                                                                            [ ]
- --------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           .04%
- --------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           PN
- --------------------------------------------------------------------------------
                      * SEE INSTRUCTION BEFORE FILLING OUT!

                                      
<PAGE>
- -------------------------------                    -----------------------------
CUSIP NO.    52728R102                13G                 Page 8 of 20 Pages
          ---------------                                                       
- -------------------------------                    -----------------------------

- --------------------------------------------------------------------------------
   1       NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON

           James H. Cavanaugh, Ph.D.
- --------------------------------------------------------------------------------
   2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  [ ]
                                                                       (b)  [ ]
           
- --------------------------------------------------------------------------------
   3       SEC USE ONLY


- --------------------------------------------------------------------------------
   4       CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER
                                    
    
                            ----------------------------------------------------
           NUMBER OF         6    SHARED VOTING POWER
            SHARES    
         BENEFICIALLY             2,485,593
             EACH           ----------------------------------------------------
           REPORTING         7    SOLE DISPOSITIVE POWER
            PERSON                         
             WITH                                
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER
                                   
                                  2,485,593
- --------------------------------------------------------------------------------
   9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,485,593
- --------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES*  
                                                                            [ ]
- --------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           21%
- --------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           IN
- --------------------------------------------------------------------------------
                      * SEE INSTRUCTION BEFORE FILLING OUT!

                                      
<PAGE>
- -------------------------------                    -----------------------------
CUSIP NO.    52728R102                13G                 Page 9 of 20 Pages
          ---------------                                                       
- -------------------------------                    -----------------------------

- --------------------------------------------------------------------------------
   1       NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON

           Harold R. Werner
- --------------------------------------------------------------------------------
   2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  [ ]
                                                                       (b)  [ ]
           
- --------------------------------------------------------------------------------
   3       SEC USE ONLY


- --------------------------------------------------------------------------------
   4       CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER
                                    
    
                            ----------------------------------------------------
           NUMBER OF         6    SHARED VOTING POWER
            SHARES    
         BENEFICIALLY             2,485,593
           OWNED BY   
             EACH           ----------------------------------------------------
           REPORTING         7    SOLE DISPOSITIVE POWER
            PERSON                         
             WITH                                
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER
                                   
                                  2,485,593
- --------------------------------------------------------------------------------
   9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,485,593
- --------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES*  
                                                                            [ ]
- --------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           21%
- --------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           IN
- --------------------------------------------------------------------------------
                      * SEE INSTRUCTION BEFORE FILLING OUT!

                                      
<PAGE>
- -------------------------------                    -----------------------------
CUSIP NO.    52728R102                13G                Page 10 of 20 Pages
          ---------------                                                       
- -------------------------------                    -----------------------------

- --------------------------------------------------------------------------------
   1       NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON

           William Crouse
- --------------------------------------------------------------------------------
   2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  [ ]
                                                                       (b)  [ ]
           
- --------------------------------------------------------------------------------
   3       SEC USE ONLY


- --------------------------------------------------------------------------------
   4       CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER
                                    
    
                            ----------------------------------------------------
           NUMBER OF         6    SHARED VOTING POWER
            SHARES    
         BENEFICIALLY             2,485,593
           OWNED BY   
             EACH           ----------------------------------------------------
           REPORTING         7    SOLE DISPOSITIVE POWER
            PERSON                         
             WITH                                
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER
                                   
                                  2,485,593
- --------------------------------------------------------------------------------
   9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,485,593
- --------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES*  
                                                                            [ ]
- --------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           21%
- --------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           IN
- --------------------------------------------------------------------------------
                      * SEE INSTRUCTION BEFORE FILLING OUT!

                                      
<PAGE>
- -------------------------------                    -----------------------------
CUSIP NO.    52728R102                13G                Page 11 of 20 Pages
          ---------------                                                       
- -------------------------------                    -----------------------------

- --------------------------------------------------------------------------------
   1       NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON

           John W. Littlechild
- --------------------------------------------------------------------------------
   2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  [ ]
                                                                       (b)  [ ]
           
- --------------------------------------------------------------------------------
   3       SEC USE ONLY


- --------------------------------------------------------------------------------
   4       CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER
                                    
    
                            ----------------------------------------------------
           NUMBER OF         6    SHARED VOTING POWER
            SHARES    
         BENEFICIALLY             2,485,593
           OWNED BY   
             EACH           ----------------------------------------------------
           REPORTING         7    SOLE DISPOSITIVE POWER
            PERSON                         
             WITH                                
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER
                                   
                                  2,485,593
- --------------------------------------------------------------------------------
   9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,485,593
- --------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES*  
                                                                            [ ]
- --------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           21%
- --------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           IN
- --------------------------------------------------------------------------------
                      * SEE INSTRUCTION BEFORE FILLING OUT!

                                      
<PAGE>
- -------------------------------                    -----------------------------
CUSIP NO.    52728R102                13G                Page 12 of 20 Pages
          ---------------                                                       
- -------------------------------                    -----------------------------

- --------------------------------------------------------------------------------
   1       NAME OF REPORTING PERSON
           S.S. OR I.R.S. IDENTIFICATION NUMBER OF ABOVE PERSON

           Mark Leschly
- --------------------------------------------------------------------------------
   2       CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*           (a)  [ ]
                                                                       (b)  [ ]
           
- --------------------------------------------------------------------------------
   3       SEC USE ONLY


- --------------------------------------------------------------------------------
   4       CITIZENSHIP OR PLACE OF ORGANIZATION

           United States
- --------------------------------------------------------------------------------
                             5    SOLE VOTING POWER
                                    
    
                            ----------------------------------------------------
           NUMBER OF         6    SHARED VOTING POWER
            SHARES    
         BENEFICIALLY             2,485,593
           OWNED BY   
             EACH           ----------------------------------------------------
           REPORTING         7    SOLE DISPOSITIVE POWER
            PERSON                         
             WITH                                
                            ----------------------------------------------------
                             8    SHARED DISPOSITIVE POWER
                                   
                                  2,485,593
- --------------------------------------------------------------------------------
   9       AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

           2,485,593
- --------------------------------------------------------------------------------
   10      CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
           SHARES*  
                                                                            [ ]
- --------------------------------------------------------------------------------
   11      PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

           21%
- --------------------------------------------------------------------------------
   12      TYPE OF REPORTING PERSON*

           IN
- --------------------------------------------------------------------------------
                      * SEE INSTRUCTION BEFORE FILLING OUT!


                                      

<PAGE>
                                                                 Page 13 of 20

Item 1.

  (a)      Name of Issuer:

           Leukosite, Inc.

  (b)      Address of Issuer's Principal Executive Offices:

           215 First Street
           Cambridge, Massachusetts 02142

Item 2.

  (a)      Name of Person Filing:

           HealthCare Ventures III, L.P. ("HCV III"), HealthCare Partners III,
           L.P. ("HCP III"), HealthCare Ventures IV, L.P. ("HCV IV"), HealthCare
           Partners IV, L.P. ("HCP IV"), HealthCare Ventures V, L.P. ("HCV V"),
           HealthCare Partners V, L.P. ("HCP V"), Dr. Cavanaugh and Messrs.
           Werner, Littlechild, Crouse and Leschly. See attached Exhibit A which
           is a copy of their agreement in writing to file this statement on
           behalf of each of them.(1)

  (b)      Address of Principal Business Office or, if none, Residence:

           The business address for HCV III, HCP III, HCV IV, HCP IV, HCV V, HCP
           V, Dr. Cavanaugh and Messrs. Werner and Crouse is 44 Nassau Street,
           Princeton, New Jersey 08542. The business address for Messrs.
           Littlechild and Leschly is One Kendall Square, Building 300,
           Cambridge, Massachusetts 02139.

  (c)      Citizenship:

           HCV III, HCP III, HCV IV, HCP IV, HCV V and HCP V are limited
           partnerships organized under the laws of the State of Delaware. Dr.
           Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are
           each United States citizens.

  (d)      Title of Class of Securities:

           Common Stock, par value $.01 ("Shares").

- --------
(1) Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly are
general partners of each of HCP III, HCP IV and HCP V, which are the general
partner of each of HCV III, HCV IV and HCV V, respectively, the record holder of
Issuer's securities.


<PAGE>

                                                                  Page 14 of 20

  (e)      CUSIP Number:

           52728R102

Item 3.    If this statement is filed pursuant to Rule 13d-1(b), or 13d-2(b), 
           check whether the person filing is a:

           Inapplicable.

Item 4.    Ownership.

  (a)      Amount Beneficially Owned:

           As of December 31, 1998: HCV III and HCP III beneficially
           owned 1,545,944 Shares of Issuer's Securities, consisting of
           Shares of Issuer's Common Stock; HCV IV and HCP IV
           beneficially owned 453,982 Shares of Issuer's Securities,
           consisting of Shares of Issuer's Common Stock; HCV V and HCP V
           beneficially owned 479,167 Shares of Issuer's Securities,
           consisting of Shares of Issuer's Common Stock; and Dr.
           Cavanaugh and Messrs. Werner, Littlechild Crouse and Leschly
           beneficially owned 2,485,593 Shares of Issuer's Securities,
           consisting of 2,479,093 Shares of Issuer's Common Stock and
           immediately exercisable options to purchaes 6,500 Shares of
           Issuer's Common Stock.(2)

  (b)      Percent of Class:

           As of December 31,1998: the 1,545,944 Shares of Issuer's
           Securities beneficially owned by HCV III and HCP III
           constitute 13% of the Issuer's Shares outstanding; the 453,982
           Shares of Issuer's Securities beneficially owned by HCV IV and
           HCP IV constitute .03% of Issuer's Shares outstanding; the
           479,167 Shares of Issuer's Securities beneficially owned by
           HCV V and HCP V constitute .04% of Issuer's Shares
           outstanding; and the 2,485,593 Shares of Issuer's Securities
           beneficially owned by Dr. Cavanaugh and Messrs. Werner,
           Littlechild, Crouse and Leschly constitute 21% of Issuer's
           Shares outstanding.

  (c) Number of shares as to which such person has:

           (i)      sole power to vote or to direct the vote:

                    Inapplicable

           (ii) shared power to vote or to direct the vote:

- --------
(2) The 6,500 options to purchase Shares of Issuer's Common Stock are held by
HealthCare Ventures, LLC, a limited liability company, the members of which are
Dr. Cavanaugh and Messrs. Werner, Littlechild, Crouse and Leschly.


<PAGE>

                                                                  Page 15 of 20


                      HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
                      Littlechild, Crouse and Leschly share the power to vote or
                      direct the vote of those shares owned by HCV III.

                      HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner,
                      Littlechild, Crouse and Leschly share the power to vote or
                      direct the vote of those shares owned by HCV IV.

                      HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner,
                      Littlechild, Crouse and Leschly share the power to vote or
                      direct the vote of those Shares owned by HCV V.

                (iii) sole power to dispose or to direct the disposition of:

                      Inapplicable

                 (iv) shared power to dispose of or to direct the disposition
                      of:

                      HCV III, HCP III, Dr. Cavanaugh and Messrs. Werner,
                      Littlechild, Crouse and Leschly share the power to dispose
                      of or direct the disposition of those shares owned by HCV
                      III.

                      HCV IV, HCP IV, Dr. Cavanaugh and Messrs. Werner,
                      Littlechild, Crouse and Leschly share the power to dispose
                      of or direct the disposition of those shares owned by HCV
                      IV.

                      HCV V, HCP V, Dr. Cavanaugh and Messrs. Werner,
                      Littlechild, Crouse and Leschly share the power to dispose
                      of or direct the disposition of those shares owned by HCV
                      V.

Item 5.    Ownership of Five Percent or less of a Class:

           Inapplicable.

Item 6.    Ownership of More than Five Percent on Behalf of Another Person:

           Inapplicable.

Item 7.    Identification and Classification of the Subsidiary Which Acquired
           the Security Being Reported on by the Parent Holding Company:

           Inapplicable.

Item 8.    Identification and Classification of Members of the Group:

           Inapplicable.


<PAGE>


                                                                  Page 16 of 20

Item 9.    Notice of Dissolution of Group:

           Inapplicable.

Item 10.   Certification:

           Inapplicable.



<PAGE>


                                                                  Page 17 of 20

                                   SIGNATURES

     After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.


Dated: February 12, 1999                 HealthCare Ventures III, L.P.,
       Princeton, New Jersey             by its General Partner, HealthCare 
                                         Partners III, L.P.,

                                          By: /s/ Jeffrey Steinberg           
                                              --------------------------------
                                              Jeffrey Steinberg
                                              Administrative Partner

Dated: February 12, 1999                 HealthCare Partners III, L.P.
       Princeton, New Jersey
                                          By: /s/ Jeffrey Steinberg           
                                              --------------------------------
                                              Jeffrey Steinberg
                                              Administrative Partner

Dated: February 12, 1999                 HealthCare Ventures IV, L.P.,
       Princeton, New Jersey             by its General Partner, HealthCare 
                                         Partners IV, L.P.,

                                          By: /s/ Jeffrey Steinberg           
                                              --------------------------------
                                              Jeffrey Steinberg
                                              Administrative Partner

Dated: February 12, 1999                 HealthCare Partners IV, L.P.
       Princeton, New Jersey
                                          By: /s/ Jeffrey Steinberg           
                                              --------------------------------
                                              Jeffrey Steinberg
                                              Administrative Partner

Dated: February 12, 1999                 HealthCare Ventures V, L.P.,
       Princeton, New Jersey             by its General Partner, HealthCare 
                                         Partners V, L.P.,

                                          By: /s/ Jeffrey Steinberg           
                                              --------------------------------
                                              Jeffrey Steinberg
                                              Administrative Partner

Dated: February 12, 1999                 HealthCare Partners V, L.P.
       Princeton, New Jersey
                                          By: /s/ Jeffrey Steinberg           
                                              --------------------------------
                                              Jeffrey Steinberg
                                              Administrative Partner

 Dated: February 12, 1999                 By:         *                       
        Princeton, New Jersey                  -------------------------------
                                               James H. Cavanaugh, Ph.D.

 Dated: February 12, 1999                 By:         *                       
        Princeton, New Jersey                  -------------------------------
                                               Harold R. Werner

<PAGE>
                                                                  Page 18 of 20


 Dated: February 12, 1999                 By:         *                       
        Cambridge, Massachusetts               -------------------------------
                                               John W. Littlechild

 Dated: February 12, 1999                 By:         *                       
        Princeton, New Jersey                  -------------------------------
                                               William Crouse

 Dated: February 12, 1999                 By:         *                       
        Cambridge, Massachusetts               -------------------------------
                                               Mark Leschly

 --------------------------

 *Signed by Jeffrey Steinberg as Attorney-in-Fact 

                                      
<PAGE>


                                                                  Page 19 of 20

                                    EXHIBIT A

                                    AGREEMENT

                          JOINT FILING OF SCHEDULE 13G

     The undersigned hereby agree to jointly prepare and file with regulatory
authorities a Schedule 13G and any future amendments thereto reporting each of
the undersigned's ownership of securities of Leukosite, Inc. and hereby affirm
that such Schedule 13G is being filed on behalf of each of the undersigned.


Dated: February 12, 1999                 HealthCare Ventures III, L.P.,
       Princeton, New Jersey             by its General Partner, HealthCare 
                                         Partners III, L.P.,

                                          By: /s/ Jeffrey Steinberg            
                                              -------------------------------- 
                                              Jeffrey Steinberg
                                              Administrative Partner

Dated: February 12, 1999                 HealthCare Partners III, L.P.
       Princeton, New Jersey
                                          By: /s/ Jeffrey Steinberg            
                                              -------------------------------- 
                                              Jeffrey Steinberg
                                              Administrative Partner

Dated: February 12, 1999                 HealthCare Ventures IV, L.P.,
       Princeton, New Jersey             by its General Partner, HealthCare 
                                         Partners IV, L.P.,

                                          By: /s/ Jeffrey Steinberg            
                                              -------------------------------- 
                                              Jeffrey Steinberg
                                              Administrative Partner

Dated: February 12, 1999                 HealthCare Partners IV, L.P.
       Princeton, New Jersey
                                          By: /s/ Jeffrey Steinberg            
                                              -------------------------------- 
                                              Jeffrey Steinberg
                                              Administrative Partner

Dated: February 12, 1999                 HealthCare Ventures V, L.P.,
       Princeton, New Jersey             by its General Partner, HealthCare 
                                         Partners V, L.P.,

                                          By: /s/ Jeffrey Steinberg            
                                              -------------------------------- 
                                              Jeffrey Steinberg
                                              Administrative Partner

Dated: February 12, 1999                 HealthCare Partners V, L.P.
       Princeton, New Jersey
                                          By: /s/ Jeffrey Steinberg            
                                              -------------------------------- 
                                              Jeffrey Steinberg
                                              Administrative Partner

 Dated: February 12, 1999                 By:         *                        
        Princeton, New Jersey                  --------------------------------
                                               James H. Cavanaugh, Ph.D.

 Dated: February 12, 1999                 By:         *                        
        Princeton, New Jersey                  --------------------------------
                                               Harold R. Werner

<PAGE>

                                                                  Page 20 of 20



 Dated: February 12, 1999                 By:         *                        
        Cambridge, Massachusetts               --------------------------------
                                               John W. Littlechild

 Dated: February 12, 1999                 By:         *                        
        Princeton, New Jersey                  --------------------------------
                                               William Crouse

 Dated: February 12, 1999                 By:         *                        
        Cambridge, Massachusetts               --------------------------------
                                               Mark Leschly

- -------------------

*Signed by Jeffrey Steinberg as Attorney-in-Fact




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