LEUKOSITE INC
POS AM, 2000-01-10
PHARMACEUTICAL PREPARATIONS
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    As filed with the Securities and Exchange Commission on January 10, 2000
                                                      Registration No. 333-90517


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549

                        POST EFFECTIVE AMENDMENT NO. 1 TO
                                    FORM S-8
                          REGISTRATION STATEMENT UNDER
                           THE SECURITIES ACT OF 1933

                                 LEUKOSITE, INC.
             (Exact Name of Registrant as Specified in Its Charter)

                  DELAWARE
      (State or Other Jurisdiction of                    04-3173859
       Incorporation or Organization        (I.R.S. Employer Identification No.)

                 75 SIDNEY STREET, CAMBRIDGE MASSACHUSETTS 02139
               (Address of Principal Executive Offices) (Zip Code)

           LEUKOSITE, INC. AMENDED AND RESTATED 1993 STOCK OPTION PLAN
                            (Full Title of the Plan)

                                 JOHN MARAGANORE
                                    PRESIDENT
                                 LEUKOSITE, INC.
                                75 SIDNEY STREET
                               CAMBRIDGE, MA 02139
                     (Name and Address of Agent For Service)

                                 (617) 679-7000
          (Telephone Number, Including Area Code, of Agent For Service)

                                    Copy to:
                             David E. Redlick, Esq.
                             Jeffrey A. Stein, Esq.
                               Hale and Dorr, LLP
                                 60 State Street
                                Boston, MA 02109


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                         DEREGISTRATION OF COMMON STOCK

         On November 8, 1999, LeukoSite, Inc. (the "Company") filed a
Registration Statement on Form S-8, Registration No. 333-90517 (the
"Registration Statement"), for the sale of 450,000 shares of common stock, par
value $0.01 per share of the Company (the "Shares") under the Company's Amended
and Restated 1993 Stock Option Plan (the "Plan"). On December 22, 1999, the
stockholders of the Company approved and adopted an Agreement and Plan of
Merger, dated as of October 14, 1999, by and among the Company, Millennium
Pharmaceuticals, Inc. and ANM, Inc., a wholly-owned subsidiary of Millennium.
Pursuant to the merger agreement, Millennium assumed the obligations of the
Company under the Plan and the Plan was terminated. This Post-Effective
Amendment No. 1 to the Registration Statement is being filed to deregister all
of the unsold shares of common stock formerly issuable under the plan,
constituting 129,279 shares.


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                                   SIGNATURES

         Pursuant to the requirements of the Securities Act of 1933, as amended,
the Registrant certifies that it has reasonable grounds to believe that it meets
all of the requirements for filing on Form S-8 and has duly caused this
Registration Statement to be signed on its behalf by the undersigned, thereunto
duly authorized, in the City of Cambridge, Commonwealth of Massachusetts, on
this 10th day of January, 2000.


                                            LEUKOSITE, INC.

                                            By:  /s/ John Maraganore
                                               -------------------------
                                                     John Maraganore

         Pursuant to the requirements of the Securities Act of 1933, as amended,
this Registration Statement has been signed below by the following persons in
the capacities and on the date indicated.

<TABLE>
<CAPTION>

 Signature                         Title                                    Date
 ---------                         -----                                    ----

<S>                                <C>                                      <C>
 /s/ John Maraganore               Chairman of the Board and                January 10, 2000
- ------------------------
 John Maraganore                   President (Principal Executive
                                   Officer)

 /s/ Kevin P. Starr                Director (Principal Financial and        January 10, 2000
- ------------------------
 Kevin P. Starr                    Accounting Officer)

 /s/ Mark J. Levin                 Director                                 January 10, 2000
- ------------------------
Mark J. Levin

</TABLE>


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