NEXSTAR PHARMACEUTICALS INC
S-8, 1996-07-10
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1




            As filed with the Securities and Exchange Commission on
                                 July 10, 1996


                                                 Registration No. 333-__________


                       SECURITIES AND EXCHANGE COMMISSION
                             WASHINGTON, D.C. 20549


                                    FORM S-8
                           REGISTRATION STATEMENT
                                    UNDER
                         THE SECURITIES ACT OF 1933

                        NEXSTAR PHARMACEUTICALS, INC.
              --------------------------------------------------
              (Exact name of issuer as specified in its charter)


   DELAWARE                                            84-1173453        
- ---------------------------------                  ----------------------
(State or other jurisdiction                       (I.R.S. Employer
of incorporation or organization)                  Identification Number)


2860 Wilderness Place
Boulder, CO                                                   80301   
- ---------------------------------                           ----------
(Address of principal executive offices)                    (zip code)


            NEXSTAR PHARMACEUTICALS, INC. 1995 DIRECTOR OPTION PLAN
            -------------------------------------------------------
                            (Full title of the plan)


                             PATRICK J. MAHAFFY
                           Chief Executive Officer
                        NeXstar Pharmaceuticals, Inc.
                            2860 Wilderness Place
                             Boulder, CO  80301
                               (303) 444-5893
                             ------------------
        (Name and address, including zip code, of agent for service)
        (Telephone number, including area code, of agent for service)


                             ------------------

                                  COPY TO:
                            Peter H. Jakes, Esq.
                          Willkie Farr & Gallagher
                             One Citicorp Center
                            153 East 53rd Street
                             New York, NY 10022
                               (212) 821-8000
<PAGE>   2
                                                          




                       CALCULATION OF REGISTRATION FEE

<TABLE>
<CAPTION>
- ------------------------------------------------------------------------------------------------------
                                             Proposed                                    
Title of                                     maximum                                      Amount
securities            Amount                 offering               Proposed maximum      of
to be                 to be                  price per              aggregate offering    registration
registered            registered(1)          share (2)              price (2)             fee
- ------------------------------------------------------------------------------------------------------
<S>                   <C>                    <C>                    <C>                   <C>
Common Stock,
$0.01 par
value per
share                 500,000(3)             $20.625                10,312,500            $3,557
</TABLE>

- --------------------------------
(1)    This Registration Statement covers the 500,000 shares of Common Stock,
       $0.01 par value per share, of NeXstar Pharmaceuticals, Inc., a Delaware
       corporation ("NeXstar" or the "Registrant"), authorized to be issued
       under the NeXstar Pharmaceuticals, Inc. 1995 Director Option Plan.

(2)    Reflects the average of the high and low prices of NeXstar Common Stock
       on July 8, 1996 on the Nasdaq National Market pursuant to Rule 457(h)
       and (c) under the Securities Act of 1933, as amended (the "Securities
       Act").

(3)    Represents shares which have not yet been issued.





                                     -2-
<PAGE>   3


                                   PART I

                          INFORMATION NOT REQUIRED
                        IN THE REGISTRATION STATEMENT

                                   PART II

                         INFORMATION REQUIRED IN THE
                           REGISTRATION STATEMENT

Item 3.  INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

         The following documents, filed with the Securities and
Exchange Commission (the "Commission") by NeXstar, a Delaware corporation, are
incorporated herein by reference:

             (a)  The Registrant's annual report on Form 10-K for
         the fiscal year ended December 31, 1995, filed pursuant to the
         Securities Exchange Act of 1934 (the "Exchange Act").

             (b)  All other reports filed by the Registrant
         pursuant to Section 13(a) or 15(d) of the Exchange Act since
         the end of the fiscal year covered by the Form 10-K referred
         to in (a) above, including, without limitation, the reports
         referred to in items (c) and (d) below.

             (c)  The Registrant's quarterly report on Form 10-Q
         for the quarter ended March 31, 1996, filed pursuant to the
         Exchange Act.

             (d)  The Registrant's current reports on Form 8-K,
         filed with the Commission on April 10, 1996, June 21,
         1996, and July 8, 1996, respectively.

             (e)  The description of NeXstar's common stock, $0.01
         par value per share (the "Common Stock"), which is contained
         in NeXagen's Registration Statement filed under the Exchange
         Act, on Form 8-A (File No. 0-23012) on December 6, 1993, as
         amended on Form 8-A/A filed on January 25, 1994.

         In addition, all documents filed by NeXstar with the Commission
pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act subsequent 
to the date of this Registration Statement and prior to the filing of a post-
effective amendment which indicates that all the securities offered hereby have
been sold or which deregisters all securities then remaining unsold shall be
deemed to be incorporated herein by reference and to be a part hereof from the
date of the filing of such documents with the Commission.  Any statement
contained in a document incorporated by reference herein shall be deemed to be
modified or superseded for





                                      -3-
<PAGE>   4


purposes hereof to the extent that a statement contained herein (or in any
other subsequently filed document which also is incorporated by reference
herein) modifies or supersedes such statement.  Any statement so modified or
superseded shall not be deemed to constitute a part hereof except as so
modified or superseded.

Item 4.  DESCRIPTION OF SECURITIES

         Inapplicable.

Item 5.  INTERESTS OF NAMED EXPERTS AND COUNSEL

         Certain legal matters with respect to the shares of Common Stock
registered hereunder will be passed upon for the Registrant by Willkie Farr &
Gallagher, New York, New York.  A member of the firm of Willkie Farr & Gallagher
owns 2,440 shares of the Registrant's Common Stock.

Item 6.  INDEMNIFICATION OF DIRECTORS AND OFFICERS

         The Registrant's By-Laws require the Registrant to indemnify any
and all of its directors or officers, or directors or officers who serve at the
request of the corporation as a director or officer of another corporation, to
the full extent permitted by the Delaware General Corporation Law (the "DGCL").

         The Registrant's Second Amended and Restated Certificate of
Incorporation (the "Certificate of Incorporation") also provides that:

         The Registrant shall indemnify to the fullest extent permitted
     under and in accordance with the laws of the State of Delaware any
     person who was or is a party or is threatened to be made a party to
     any threatened, pending or completed action, suit or proceeding,
     whether civil, criminal, administrative or investigative by reason of
     the fact that he is or was a director, officer, employee or agent of
     the Registrant, or is or was serving at the request of the Registrant
     as a director, officer, trustee, employee or agent of or in any other
     capacity with another corporation, partnership, joint venture, trust
     or other enterprise, against expenses (including attorneys' fees),
     judgments, fines and amounts paid in settlement actually and
     reasonably incurred by him in connection with such action, suit or
     proceeding if he acted in good faith and in a manner he reasonably
     believed to be in or not opposed to the best interests of the
     Registrant, and, with respect to any criminal action or proceeding,
     had no reasonable cause to believe his conduct was unlawful.

         Expenses incurred in defending a civil or criminal action, suit
     or proceeding shall (in the case of any action, suit or proceeding
     against a director of the Registrant) or may (in the case of any
     action, suit or proceeding against an officer, trustee, employee or
     agent) be paid by the Registrant in advance of the final disposition
     of such action, suit or proceeding as authorized by the Registrant's
     Board of Directors upon receipt of an undertaking by or on behalf of
     the indemnified person to repay such amount if it shall





                                      -4-
<PAGE>   5


     ultimately be determined that he is not entitled to be indemnified by
     the Registrant as authorized in the Registrant's Certificate of
     Incorporation.

         The indemnification and other rights set forth in the
     Certificate of Incorporation shall not be exclusive of any provisions
     with respect thereto in the By-Laws or any other contract or agreement
     between the Registrant and any officer, director, employee or agent of
     the Registrant.

         Neither the amendment nor repeal of the provisions (described
     above) in the Certificate of Incorporation regarding indemnification,
     nor the adoption of any provision of the Certificate of Incorporation
     inconsistent with such provisions, shall eliminate or reduce the
     effect of such provisions, in respect of any matter occurring prior to
     such amendment, repeal or adoption of an inconsistent provision or in
     respect of any cause of action, suit or claim relating to any such
     matter which would have given rise to a right of indemnification or
     right to receive expenses pursuant to such provisions, if such
     provision had not been so amended or repealed or if a provision
     inconsistent therewith had not been so adopted.

         No director shall be personally liable to the Registrant or any
     stockholder for monetary damages for breach of fiduciary duty as a
     director, except for any matter in respect of which such director (A)
     shall be liable under Section 174 of the DGCL or any amendment thereto
     or successor provision thereto, or (B) shall be liable by reason that,
     in addition to any and all other requirements for liability he:

           (i)      shall have breached his duty of loyalty to the
     Registrant or its stockholders;

           (ii)     shall not have acted in good faith or, in failing to act,
     shall not have acted in good faith;

           (iii)    shall have acted in a manner involving intentional 
     misconduct or a knowing violation of law or, in failing to act, shall have
     acted in a manner involving intentional misconduct or a knowing violation 
     of law; or

           (iv)     shall have derived an improper personal benefit.

         If the DGCL is amended after the date upon which a document is
     filed in the State of Delaware to authorize corporate action further
     eliminating or limiting the personal liability of directors, then the
     liability of a director of the Registrant shall be eliminated or
     limited to the fullest extent permitted by the DGCL, as so amended.

         Section 145 of the DGCL empowers a Delaware corporation to
     indemnify any persons who are, or are threatened to be made,





                                      -5-
<PAGE>   6


     parties to any threatened, pending or completed legal action,
     suit or proceeding, whether civil, criminal, administrative or
     investigative (other than an action by or in the right of such
     corporation), by reason of the fact that such person is or was
     an officer or director of such corporation, or is or was serving
     at the request of such corporation as a director, officer,
     employee or agent of another corporation or enterprise.  The
     indemnity may include expenses (including attorneys' fees),
     judgments, fines and amounts paid in settlement actually and
     reasonably incurred by such person in connection with such
     action, suit or proceeding, provided that such officer or
     director acted in good faith and in a manner reasonably believed
     to be in or not opposed to the corporation's best interests,
     and, for criminal proceedings, had no reasonable cause to
     believe his conduct was illegal.  A Delaware corporation may
     indemnify officers and directors in an action by or in the right
     of the corporation under the same conditions, except that no
     indemnification is permitted without judicial approval if the
     officer or director is adjudged to be liable to the corporation
     in the performance of his duty.  Where an officer or director is
     successful on the merits or otherwise in the defense of any
     action referred to above, the corporation must indemnify him
     against the expenses which such officer or director actually and
     reasonably incurred.

Item 7.  EXEMPTION FROM REGISTRATION CLAIMED

         Inapplicable.

Item 8.  EXHIBITS

Exhibit No.
- -----------

4.1      Second Amended and Restated Certificate of Incorporation of
         the Registrant (Previously filed as an exhibit to the
         Registrant's Registration Statement on Form S-3 (File No.
         333-04653), declared effective by the Commission on June 19,
         1996, and incorporated herein by reference.)

4.2      Form of Common Stock Certificate of the Registrant (Previously
         filed as an exhibit to the Registrant's Annual Report on Form
         10-K for the fiscal year ended December 31, 1994, and
         incorporated herein by reference.)

5.1      Opinion of Willkie Farr & Gallagher, counsel to NeXstar, as to
         the legality of the shares being registered.

23.1     Consent of Ernst & Young LLP.

23.2     Consent of Willkie Farr & Gallagher (contained in exhibit 5.1). 

24.1     Power of Attorney (reference is made to the signature page).





                                      -6-
<PAGE>   7



99.1     Registrant's 1995 Director Option Plan (Previously filed as an
         exhibit to the Registrant's Quarterly Report on Form 10-Q for
         the quarterly period ended September 30, 1995, and
         incorporated herein by reference.)

Item 9.  UNDERTAKINGS

         1.  NeXstar hereby undertakes:

         (a)  To file, during any period in which offers or sales are
     being made, a post-effective amendment to this Registration Statement:

              (i)  to include any prospectus required by Section 10(a)(3) of the
         Securities Act;

              (ii) to reflect in the prospectus any facts or events arising
         after the effective date of the Registration Statement (or the most
         recent post-effective amendment thereof) which, individually or in 
         the aggregate, represent a fundamental change in the information set
         forth in the Registration Statement;

              (iii)to include any material information with
         respect to the plan of distribution not previously disclosed
         in the Registration Statement or any material change to such
         information in the Registration Statement;

     provided, however, that paragraphs (a)(i) and (a)(ii) do not apply if
     the information required to be included in a post-effective amendment
     by those paragraphs is contained in periodic reports filed by NeXstar
     pursuant to Section 13 or Section 15(d) of the Exchange Act that are
     incorporated by reference in the Registration Statement.

         (b)  That, for the purpose of determining any liability
     under the Securities Act, each such post-effective amendment shall be
     deemed to be a new registration statement relating to the securities
     offered therein, and the offering of such securities at that time
     shall be deemed to be the initial bona fide offering thereof.

         (c)  To remove from registration by means of a post-effective
     amendment any of the securities being registered which remain unsold at
     the termination of the offering.

         2.   NeXstar hereby undertakes that, for purposes of determining any
liability under the Securities Act, each filing of NeXstar's annual report
pursuant to Section 13(a) or Section 15(d) of the Exchange Act that is
incorporated by reference in the Registration Statement shall be deemed to be a
new registration statement relating to the securities offered therein, and the
              




                                      -7-
<PAGE>   8


offering of such securities at that time shall be deemed to be the initial
bona fide offering thereof.

         3.       NeXstar  hereby undertakes to deliver or cause to be
delivered with the prospectus, to each person to whom the prospectus is sent
or given, the latest annual report to security holders that is incorporated by 
reference in the prospectus and furnished pursuant to and meeting the 
requirements of Rule 14a-3 or Rule 14c-3 under the Exchange Act; and, where
interim financial information required to be presented by Article 3 of 
Regulation S-X are not set forth in the prospectus, to deliver, or cause to be
delivered to each person to whom the prospectus is sent or given, the latest 
quarterly report that is specifically incorporated by reference in the
prospectus to provide such interim financial information.

         4.       Insofar as indemnification for liabilities arising under the
Securities Act may be permitted to directors, officers and controlling persons
of NeXstar pursuant to the foregoing provisions, or otherwise, NeXstar has 
been advised that in the opinion of the Commission such indemnification is 
against public policy as expressed in the Securities Act and is, therefore, 
unenforceable.  In the event that a claim for indemnification against such 
liabilities (other than the payment by NeXstar of expenses incurred or paid by 
a director, officer or controlling person of NeXstar in the successful defense
of any action, suit or proceeding) is asserted by such director, officer or
controlling person in connection with the securities being registered, NeXstar 
will, unless in the opinion of its counsel the matter has been settled by
controlling precedent, submit to a court of appropriate jurisdiction the
question whether such indemnification by it is against public policy as 
expressed in the Securities Act and will be governed by the final adjudication
of such issue.





                                      -8-
<PAGE>   9



                                 SIGNATURES


           Pursuant to the requirements of the Securities Act of 1933, as
amended, the registrant certifies that it has reasonable grounds to believe
that it meets all of the requirements for filing on Form S-8 and has duly
caused this Registration Statement to be signed on its behalf by the
undersigned, thereunto duly authorized, in Boulder, Colorado on the 10th day of
July 1996.

                                                   NEXSTAR PHARMACEUTICALS, INC.


                                                   By:  /s/ Patrick J. Mahaffy  
                                                        ----------------------
                                                        Patrick J. Mahaffy
                                                        President and
                                                        Chief Executive Officer





                                      -9-
<PAGE>   10


                              POWER OF ATTORNEY

                 KNOW ALL MEN BY THESE PRESENTS, that each person whose
signature appears below constitutes and appoints Patrick J. Mahaffy, Michael E.
Hart and Adam Cochran and each of them singly, with full power to act without
the other, his true and lawful attorney-in-fact and agent, with full power of
substitution and resubstitution, for him and in his name, place and stead, in
any and all capacities, to sign any and all amendments to this Registration
Statement, and to file the same, with all exhibits thereto, and other documents
in connection therewith, with the Securities and Exchange Commission, granting
unto said attorneys-in-fact and agents, and each of them, full power and
authority to do and perform each and every act and thing requisite and
necessary fully to all intents and purposes as he might or could do in person
thereby ratifying and confirming all that said attorneys-in-fact and agents or
any of them, or their or his substitutes or substitute, may lawfully do or
cause to be done by virtue hereof.

                 Pursuant to the requirements of the Securities Act of 1933, as
amended, this Registration Statement has been signed by the following persons
in the capacities and on the dates indicated.



<TABLE>
<CAPTION>
Signature                               Title                             Date
- ---------                               -----                             ----
<S>                                     <C>                               <C>
/s/ Lawrence M. Gold                    Chairman of the Board             July 10, 1996
- --------------------------------------  and Chief Scientific Offer
Lawrence M. Gold                        


/s/ Patrick J. Mahaffy                  Director, President and           July 10, 1996
- --------------------------------------  Chief Executive Officer                                                
Patrick J. Mahaffy                      (Principal Executive Officer)
                                        

/s/ Michael E. Hart                     Vice President and                July 10, 1996
- --------------------------------------  Chief Financial Officer
Michael E. Hart                         (Principal Financial Officer
                                        and Principal Accounting
                                        Officer)
                                                                                        
                         
/s/ John D. Baldeschwieler              Director                          July 10, 1996
- --------------------------------------                                                  
John D. Baldeschwieler


/s/ James A. Eskridge                   Director                          July 10, 1996
- --------------------------------------                                                  
James A. Eskridge


/s/ David I. Hirsh                      Director                          July 10, 1996
- --------------------------------------                                                  
David I. Hirsh


/s/ Rodman W. Moorhead, III             Director                          July 10, 1996
- --------------------------------------                                                  
Rodman W. Moorhead, III


/s/ Carl F. Pollard                     Director                          July 10, 1996
- --------------------------------------                                                  
Carl F. Pollard

</TABLE>





                                      -10-
<PAGE>   11





                              INDEX TO EXHIBITS


<TABLE>
<CAPTION>

                                                                                            Sequentially
                                                                                              Numbered
Exhibit No.                                      Exhibit                                        Page    
- -----------                                      -------                                    ------------
<S>           <C>                                                                           <C>

4.1           Second Amended and Restated Certificate of Incorporation of
              the Registrant (Previously filed as an exhibit to the
              Registrant's Registration Statement on Form S-3 (File No.
              333-04653), declared effective by the Commission on June 19,
              1996, and incorporated herein by reference.)

4.2           Form of Common Stock Certificate of the Registrant
              (Previously filed as an exhibit to the Registrant's Annual
              Report on Form 10-K for the fiscal year ended December 31,
              1994, and incorporated herein by reference.)

5.1           Opinion of Willkie Farr & Gallagher, counsel to NeXstar, as                
              to the legality of the shares being registered.

23.1          Consent of Ernst & Young LLP.                                              

23.2          Consent of Willkie Farr & Gallagher (contained in exhibit
              5.1).

24.1          Power of Attorney (reference is made to the signature page).

99.1          Registrant's 1995 Director Option Plan (Previously filed as
              an exhibit to the Registrant's Quarterly Report on Form 10-Q
              for the quarterly period ended September 30, 1995, and
              incorporated herein by reference.)

</TABLE>




                                     

<PAGE>   1




                                                                EXHIBIT 5.1





July 10, 1996




NeXstar Pharmaceuticals, Inc.
2860 Wilderness Place
Boulder, Colorado  80301

Dear Sirs:

We are delivering this opinion in connection with the Registration Statement on
Form S-8 (the "Registration Statement") of NeXstar Pharmaceuticals, Inc. (the
"Company") to be filed with the Securities and Exchange Commission under the
Securities Act of 1933, as amended (the "Securities Act"), with respect to an
aggregate of 500,000 shares, par value $.01 per share, of common stock of the
Company (the "Shares").  The Shares are to be offered pursuant to the terms of
the Company's 1995 Director Option Plan (the "Plan") to participants in the
Plan (the "Participants").  We have examined and are familiar with originals or
copies, certified or otherwise identified to our satisfaction, of such
documents, corporate records and other instruments relating to the
incorporation of the Company and to the authorization and issuance of the
Shares, and have made such investigations of law, as we have deemed necessary
and advisable.

Based upon the foregoing and having due regard for such legal questions as we
have deemed relevant, we are of the opinion that:

1.       The Company is duly incorporated and validly existing under the laws
         of the State of Delaware; and

2.       The Shares have been duly authorized and, when issued, delivered and
         sold by the Company and paid for by the Participants, pursuant to the
         terms of the Plan, will constitute duly authorized, validly issued,
         fully paid and nonassessable shares of common stock of the Company.





<PAGE>   2


NeXstar Pharmaceuticals, Inc.
July 10, 1996
Page 2


We hereby consent to the filing of this opinion as an exhibit to the
Registration Statement referred to above and to the reference to our firm in
the summary of the Plan provided to the Participants, which, together with the
documents incorporated by reference in the Registration Statement, constitute a
prospectus that meets the requirements of Section 10(a) of the Securities Act.

Very truly yours,



/s/ Willkie Farr & Gallagher






<PAGE>   1




                                                                EXHIBIT 23.1






                        CONSENT OF INDEPENDENT AUDITORS

We consent to the incorporation by reference in the Registration Statement 
(Form S-8) pertaining to the NeXstar Pharmaceuticals, Inc. 1995 Director 
Option Plan of NeXstar Pharmaceuticals, Inc. of our report dated February 16, 
1996, with respect to the consolidated financial statements of NeXstar 
Pharmaceuticals, Inc. included in its Annual Report (Form 10-K) for the year 
ended December 31, 1995, filed with the Securities and Exchange Commission.



                                    /s/ ERNST & YOUNG LLP
                                        ERNST & YOUNG LLP

Denver, Colorado
July 10, 1996







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