NEXSTAR PHARMACEUTICALS INC
424B3, 1998-04-13
PHARMACEUTICAL PREPARATIONS
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                                               Filed Pursuant to Rule 424(b)(3)
                                               Registration No. 333-35827       



                      SUPPLEMENT NO. 3 DATED APRIL 13, 1998
                       TO PROSPECTUS DATED OCTOBER 6, 1997
                                   RELATING TO
         $80,000,000 6 1/4% CONVERTIBLE SUBORDINATED DEBENTURES DUE 2004
                    INTEREST PAYABLE FEBRUARY 1 AND AUGUST 1
           AND SHARES OF COMMON STOCK ISSUABLE UPON CONVERSION THEREOF

     All capitalized terms used but not defined herein shall have the meanings
set forth in the Prospectus dated October 10, 1997, as previously supplemented
(the "Prospectus"), forming a part of the Registration Statement on Form S-3
(Registration No. 333-35827). Any cross references in this Supplement refer to
portions of the Prospectus.

     The purpose of this Supplement is to provide additional information
regarding the Selling Securityholders. In addition to the Selling
Securityholders named in the Prospectus, the following table sets forth the name
of each additional Selling Securityholder and relationship, if any, with the
Company and (i) the amount of Debentures owned by each additional Selling
Securityholder as of April 13, 1998 (subject to the qualification set forth
below), (ii) the maximum amount of Debentures which may be offered for the
account of such additional Selling Securityholder under the Prospectus, (iii)
the amount of Common Stock owned by each additional Selling Securityholder as of
April 13, 1998, and (iv) the maximum amount of Common Stock which may be offered
for the account of such Selling Securityholder under the Prospectus.

<TABLE>
<CAPTION>



Name of Selling Securityholder  Principal Amount           Principal Amount        Shares of      Shares of Common
                                of Debentures Owned        of Debentures           Common Stock   Stock Offered Hereby
                                                           Offered Hereby          Owned  Prior   (2)
                                                                                   to Offering
                                                                                   (1)
<S>                              <C>                     <C>                     <C>                  <C>    
SBC   Warburg    Dillon   Read    $2,500,000              $2,500,000              148,148              148,148
   Inc.(3)...................
CIBC Oppenheimer.............      1,500,000               1,500,000               88,889               88,889
NHBD, LP.....................        250,000                 250,000               14,815               14,815
Total........................     $4,250,000              $4,250,000                  N/A              251,852
                                  ==========              ==========                  ===              =======
- -----------------------
</TABLE>


(1)  Includes the shares of Common Stock into which the Debentures held by such
     Selling Securityholder are convertible at the initial conversion price. The
     conversion price and the number of shares of Common Stock issuable upon
     conversion of the Debentures are subject to adjustment under certain
     circumstances. See "Description of Debentures - Conversion Rights."
     Accordingly, the number of shares of Common Stock issuable upon conversion
     of the Debentures may increase or decrease from time to time.

(2)  Assumes conversion into Common Stock of the full amount of Debentures held
     by such Selling Securityholder at the initial conversion price. The
     conversion price and the number of shares of Common Stock issuable upon
     conversion of the Debentures are subject to adjustment under certain
     circumstances. See "Description of Debentures - Conversion Rights."
     Accordingly, the number of shares of Common Stock issuable upon conversion
     of the Debentures may increase or decrease from time to time. Fractional
     shares will not be issued upon conversion of the Debentures; rather, cash
     will be paid in lieu of fractional shares, if any.

(3)  SBC Warburg Dillon Read Inc.  (formerly SBC Warburg Inc.) and Oppenheimer &
     Co., Inc. were Initial  Purchasers of the Company's  $80,000,000  aggregate
     principal  amount of Debentures.  The sale of the Debentures by the Company
     to the  Initial  Purchasers  was  made  pursuant  to  Section  4(2)  of the
     Securities  Act of 1933.  The Initial  Purchasers  resold the Debentures in
     reliance  on Rule 144A under the  Securities  Act of 1933 and  outside  the
     United States to certain  persons in offshore  transactions  in reliance on
     Regulation S


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<PAGE>



underthe Securities Act of 1933. The Initial Purchasers received discounts and
commissions in connection with the initial placement of the Debentures of
$2,400,000. The Debentures set forth opposite the name of SBC Warburg Dillon
Read Inc. represent securities held by it in its market making capacity.

     Because the Selling Securityholders may, pursuant to this Prospectus, offer
all or some portion of the Debentures and Common Stock they presently hold or,
with respect to Common Stock, have the right to acquire upon conversion of such
Debentures, no estimate can be given as to the amount of the Debentures and
Common Stock that will be held by the Selling Securityholders upon termination
of any such sales. In addition, the Selling Securityholders identified above may
have sold, transferred or otherwise disposed of all or a portion of their
Debentures and Common Stock since the date on which they provided the
information regarding their Debentures and Common Stock, in transactions exempt
from the registration requirements of the Securities Act of 1933. See "Plan of
Distribution."

     The Company may from time to time, in accordance with the Registration
Rights Agreement, include additional Selling Securityholders in future
supplements to the Prospectus.

     Except as described above, none of the Selling Securityholders listed above
had any material relationship with the Company other than as a result of
ownership of the Debentures, within the three-year period ending on the date of
this Prospectus.




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