NEXSTAR PHARMACEUTICALS INC
424B3, 1998-02-06
PHARMACEUTICAL PREPARATIONS
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                                               Filed Pursuant to Rule 424(b)(3)
                                               Registration No. 333-35827       

                     SUPPLEMENT NO. 2 DATED FEBRUARY 6, 1998
                       TO PROSPECTUS DATED OCTOBER 6, 1997
                                   RELATING TO
         $80,000,000 6-1/4% CONVERTIBLE SUBORDINATED DEBENTURES DUE 2004
                    INTEREST PAYABLE FEBRUARY 1 AND AUGUST 1
           AND SHARES OF COMMON STOCK ISSUABLE UPON CONVERSION THEREOF

         All capitalized terms used but not defined herein shall have the
meanings set forth in the Prospectus dated October 6, 1997, as previously
supplemented (the "Prospectus"), forming a part of the Registration Statement on
Form S-3 (Registration No. 333-35827). Any cross references in this Supplement
refer to portions of the Prospectus.

         The purpose of this Supplement is to provide additional information
regarding the Selling Securityholders. In addition to the Selling
Securityholders named in the Prospectus, the following table sets forth the name
of each additional Selling Securityholder and relationship, if any, with the
Company and (i) the amount of Debentures owned by each additional Selling
Securityholder as of February 6, 1998 (subject to the qualification set forth
below), (ii) the maximum amount of Debentures which may be offered for the
account of such additional Selling Securityholder under the Prospectus, (iii)
the amount of Common Stock owned by each additional Selling Securityholder as of
February 6, 1998, and (iv) the maximum amount of Common Stock which may be
offered for the account of such Selling Securityholder under the Prospectus.
<TABLE>
<CAPTION>


                                                                              
                                                       Principal Amount of     Shares of Common                                
                                  Principal Amount      Debentures Offered        Stock Owned            Shares of Common      
Name of Selling Securityholder  of Debentures Owned        Hereby             Prior to Offering (1)   Stock Offered Hereby (2)      
- ------------------------------  -------------------    -------------------    ---------------------   ------------------------
<S>                             <C>                    <C>                     <C>                     <C>   

Alexandra Global Investment
   Fund 1, Ltd. .............     $5,000,000             $5,000,000               296,296                  296,296
                                
Donaldson, Lufkin & Jenrette
   Securities Corporation....      4,000,000              4,000,000               237,037                  237,037
Forest Fulcrum Fd LP.........      1,870,000              1,870,000               110,815                  110,815
Forest Global Convertible
   Fund Series A-5...........      1,000,000              1,000,000                59,259                   59,259
LLT LTD......................        130,000                130,000                 7,704                    7,704
                                  -----------             -----------             -------                 --------
Total........................    $12,000,000            $12,000,000                 N/A                    711,111
                                  ===========             ===========             =======                 ========
</TABLE>

- -----------------------
(1)  Includes the shares of Common Stock into which the Debentures held by such
     Selling Securityholder are convertible at the initial conversion price. The
     conversion price and the number of shares of Common Stock issuable upon
     conversion of the Debentures are subject to adjustment under certain
     circumstances. See "Description of Debentures - Conversion Rights."
     Accordingly, the number of shares of Common Stock issuable upon conversion
     of the Debentures may increase or decrease from time to time.

(2)  Assumes conversion into Common Stock of the full amount of Debentures held
     by such Selling Securityholder at the initial conversion price. The
     conversion price and the number of shares of Common Stock issuable upon
     conversion of the Debentures are subject to adjustment under certain
     circumstances. See "Description of Debentures - Conversion Rights."
     Accordingly, the number of shares of Common Stock issuable upon conversion
     of the Debentures may increase or decrease from time to time. Fractional
     shares will not be issued upon conversion of the Debentures; rather, cash
     will be paid in lieu of fractional shares, if any.

         Because the Selling Securityholders may, pursuant to this Prospectus,
offer all or some portion of the Debentures and Common Stock they presently hold
or, with respect to Common Stock, have the right to acquire upon conversion of
such Debentures, no estimate can be given as to the amount of the Debentures and
Common Stock that will be held by the Selling Securityholders upon termination
of any such sales. In addition, the Selling Securityholders identified above may
have sold, transferred or otherwise disposed of all or a portion of their

<PAGE>


         Debentures and Common Stock since the date on which they provided the
information regarding their Debentures and Common Stock, in transactions exempt
from the registration requirements of the Securities Act of 1933. See "Plan of
Distribution."

         The Company may from time to time, in accordance with the Registration
Rights Agreement, include additional Selling Securityholders in future
supplements to the Prospectus.

         Except as described above, none of the Selling Securityholders listed
above had any material relationship with the Company other than as a result of
ownership of the Debentures, within the three-year period ending on the date of
this Prospectus.




















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