NATURAL MICROSYSTEMS CORP
S-3, 1996-08-29
TELEPHONE & TELEGRAPH APPARATUS
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        As filed with the Securities and Exchange Commission on August __, 1996
                                                   Registration No.  333-      

                   SECURITIES AND EXCHANGE COMMISSION

                        Washington, D.C.  20549
                                   
                                FORM S-3

                       REGISTRATION STATEMENT UNDER
                        THE SECURITIES ACT OF 1933

                     NATURAL MICROSYSTEMS CORPORATION                          
            (Exact name of Registrant as specified in its charter)
              
                   Delaware                                04-2814586          
          (State or Other Jurisdiction                 (I.R.S.  Employer
       of Incorporation or Organization)             Identification Number)
                                               
                                               
                                 8 Erie Drive
                       Natick, Massachusetts 01760-1339 
                                (508) 650-1300
  (Address and Telephone Number of Registrant's Principal Executive Offices)

                            Robert P.  Schechter
                     President and Chief Executive Officer
                       Natural MicroSystems Corporation
                                 8 Erie Drive
                       Natick, Massachusetts  01760-1339
                                (508) 650-1300
           (Name, Address and Telephone Number of Agent for Service)

                                   Copy to:
                            Richard N. Hoehn, Esq.
                            Choate, Hall & Stewart
                                Exchange Place
                                53 State Street
                         Boston, Massachusetts   02109
         
         Approximate date of commencement of proposed sale to the public:  From
time to time after this Registration Statement becomes effective.

         If the only securities being registered on this form are being
offered pursuant to a dividend or interest reinvestment plan, please check the
following box. [  ]  
         
         If any of the securities being registered on this form are to be
offered on a delayed or continuous basis pursuant to Rule 415 under the
Securities Act of 1933 other than securities offered only in connection with
dividend or interest reinvestment plans, check the following box. [  ]    

         If this Form is filed to register additional securities for an
offering pursuant to Rule 462(b) under the Securities Act, check the following
box and list the Securities Act registration statement number of earlier
effective registration statement for the same offering. [  ]   __________
         
         If this Form is a post-effective amendment filed pursuant to a
Rule 462(c) under the Securities Act, check the following box and list the
Securities Act registration statement number of the earlier effective
registration statement for the same offering. [  ] ___________    

         If delivery of the prospectus is expected to be made pursuant to
Rule 434, please check the following box. [  ]   
         
         If any class of securities is to be concurrently registered on this
Form pursuant to Section 12(b) of the Securities Exchange Act of 1934 pursuant
to General Instruction V, please check the following box.  [  ] 
         
         C A L C U L A T I O N   O F   R E G I S T R A T I O N   F E E
                                      
                                      Proposed         Proposed
                                      Maximum          Maximum
Title of each                         Offering         Aggregate   Amount of
Class of Securities   Amount to be    Price            Offering    Registration
To be Registered      Registered (1)  Per Share (2)    Price (2)   Fee
- -------------------   --------------  -------------    ---------   ------------

Common Stock,         22,801
$.01 par value        shares          $39.00           $889,239    $306.64

(1)     Plus such additional number  of shares as may be required in the event 
        of a stock dividend, split-up of shares, recapitalization or other 
        similar change in the Common Stock.

(2)     Estimated solely for the purpose of calculating the registration fee,
        in accordance with Rule 457 under the Securities Act, on the basis of
        the average of  the high and low  sale prices of the  Common Stock on
        August 23, 1996 as reported on the Nasdaq National Market.  

         
         The Registrant hereby amends this Registration Statement on such date
or dates  as may be necessary to delay its effective date until the Registrant
shall  file   a  further  amendment   which  specifically  states   that  this
Registration  Statement shall thereafter  become effective in  accordance with
Section  8(a)  of the  Securities  Act  of  1933 or  until  this  Registration
Statement shall become effective on such  date as the Securities and  Exchange
Commission, acting pursuant to said Section 8(a), may determine.         
                                      
















                    
                    
                    
                    
                    
                    



                    
                    SUBJECT TO COMPLETION, September __, 1996

                               22,801 SHARES

                       Natural MicroSystems Corporation

                                COMMON STOCK

      The  Prospectus relates  to  the  resale of  up  to  22,801 shares  (the
"Shares") of Common Stock,  $.01 par value per share, of  Natural MicroSystems
Corporation (the "Company") held  by certain stockholders of the  Company (the
"Selling Stockholders").
                          _________________________ 

      THE COMMON STOCK OFFERED HEREBY INVOLVES  A HIGH DEGREE OF RISK.   FOR A
DISCUSSION  OF CERTAIN FACTORS WHICH  SHOULD BE CONSIDERED  IN CONNECTION WITH
THE PURCHASE OF THESE SECURITIES, SEE "RISK FACTORS" BEGINNING ON PAGE 5.  
                          _________________________ 

      The  Selling   Stockholders  and  their  agents,  donees,  distributees,
pledgees and  other successors in interest may offer and sell the Shares  from  
time to  time  in  one  or  more  transactions on  The Nasdaq Stock Market, or 
otherwise, at market  prices then  prevailing or  in  negotiated transactions.
The Shares may also be sold pursuant to  option, hedging or other transactions 
with  broker-dealers.   The  Shares  may  also  be  offered  in  one  or  more 
underwritten offerings.  The underwriters in an underwritten offering, if any, 
and  the  terms  and  conditions  of  any  such  offering will be described in
a  supplement to  this Prospectus.   See "Selling  Stockholders" and  "Plan of
Distribution."

      The Company  will not receive any of  the proceeds from the  sale of the
Shares by the Selling Stockholders.  See "Use of Proceeds".

      The Common Stock of the Company is traded on the National Market of  The
Nasdaq  Stock Market (the "Nasdaq  National Market") under  the symbol "NMSS".
On September ___, 1996, the  last reported  sale price  of Common  Stock on  the
Nasdaq National Market was $______ per share.
                          _________________________ 

 THESE SECURITIES HAVE NOT BEEN APPROVED OR DISAPPROVED BY THE SECURITIES 
   AND EXCHANGE COMMISSION OR ANY STATE SECURITIES COMMISSION  NOR  HAS  
    THE  SECURITIES  AND  EXCHANGE COMMISSION OR ANY STATE SECURITIES 
          COMMISSION  PASSED  UPON THE  ACCURACY  OR ADEQUACY OF
                   THIS PROSPECTUS.  ANY REPRESENTATION TO
                     THE CONTRARY IS A CRIMINAL OFFENSE.
                             ___________________ 

             The date of this Prospectus is September __, 1996.



                             
                             AVAILABLE INFORMATION

      The  Company  is  subject  to  the  informational  requirements  of  the
Securities  Exchange Act  of 1934,  as amended  (the "Exchange  Act"), and  in
accordance  therewith files  reports, proxy  statements and  other information
with the Securities and Exchange Commission (the "Commission").  Such reports,
proxy  statements  and  other  information  filed  by  the  Company  with  the
Commission  pursuant to the informational requirements of the Exchange Act may
be inspected and  copied at the public reference facilities  maintained by the
Commission  at 450  Fifth Street,  N.W., Washington,  D.C.   20549 and  at the
Commission's regional offices located at Seven World Trade Center, 13th Floor,
New   York,  New York   10048,  and at  Northwestern Atrium  Center, 500  West
Madison  Street,  Suite  1400,  Chicago, Illinois    60661.    Copies of  such
materials  also  may be  obtained from  the  Public Reference  Section  of the
Commission at  450 Fifth Street, N.W.,  Washington, D.C.  20549  at prescribed
rates.   The Common  Stock of  the Company is  traded on  the Nasdaq  National
Market.    Reports, proxy  statements  and  other information  concerning  the
Company  also may  be  inspected at  the  National Association  of  Securities
Dealers, Inc., 1735 K Street, N.W., Washington, D.C.  20006.

      The  Company has filed with  the Commission a  Registration Statement on
Form S-3 under the Securities Act of 1933, as amended  (the "Securities Act"),
with respect  to the Common  Stock offered hereby.   This Prospectus  does not
contain all of the information set forth in the Registration Statement and the
exhibits  and schedules filed therewith.  For further information with respect
to the Company  and the Common Stock offered hereby,  reference is hereby made
to  such  Registration  Statement and  to  the  exhibits  and schedules  filed
therewith.   Statements contained in this Prospectus regarding the contents of
any  agreement or  other document  are not necessarily  complete, and  in each
instance reference is made to the copy  of such agreement or document filed as
an  exhibit to the Registration Statement, each such statement being qualified
in all respects by such reference.   The Registration Statement, including the
exhibits  and  schedules  thereto, may  be  inspected  without  charge at  the
principal office of the  Commission, 450 Fifth Street, N.W.,  Washington, D.C.
20549, and copies of all or any part thereof  may be obtained from such office
upon payment of the prescribed fees.

                INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

      The following documents filed  by the Company with the  Commission (File
No.  0-14805) are incorporated herein  by reference: (1)  the Company's Annual
Report on  Form 10-K  for the  fiscal year ended  December 31,  1995; (2)  the
Company's interim reports on Form 10-Q for the fiscal quarters ended March 31,
1996 and June  30, 1996; (3)  the Company's current  report on Form 8-K  filed
with the  Commission on June 28,  1966, as amended by Form 8-K/A filed  by the
Company with the Commission on August 12, 1996; and (4) the description of the
Company's Common Stock incorporated by reference in the Company's registration
statement on  Form 8-A (SEC  File No.  0-23282) filed with  the Commission  on
January 25, 1994  from the registration  statement on Form  S-1 (SEC File  No.
33-72596) filed with the Commission on December 6, 1993.



                                       2





      
      In  addition, all  documents filed  by the  Company with  the Commission
pursuant to Sections 13(a), 13(c), 14  or 15(d) of the Exchange Act subsequent
to the date hereof and prior to  the termination of the offering of the Common
Stock registered hereby  shall be deemed to be incorporated  by reference into
this  Prospectus and  to be  a part  hereof from  the date  of filing  of such
documents.   Any statements contained in a  document incorporated or deemed to
be  incorporated  by  reference herein  shall  be  deemed  to be  modified  or
superseded  for purposes  of this  Prospectus to  the extent that  a statement
contained herein  or in any other subsequently filed document which also is or
is deemed to be  incorporated by reference herein modifies or  supersedes such
statement.   Any  statement  so modified  or superseded  shall not  be deemed,
except as  so modified or superseded, to constitute a part of this Prospectus.
The Company will provide without charge to each person to whom this Prospectus
is delivered, upon  a written request of such person, a  copy of any or all of
the  foregoing documents incorporated by reference into this Prospectus (other
than  exhibits  to such  documents,  unless  such  exhibits  are  specifically
incorporated  by reference  into such  documents).   Requests for  such copies
should  be directed  to the  Chief Financial  Officer of  the Company,  8 Erie
Drive, Natick, Massachusetts 01760-1339, Telephone:  (508) 650-1300.

                                  THE COMPANY

      The Company  designs, manufactures  and markets integrated  hardware and
software products which enable its customers to develop and implement computer
telephony   applications  and   telecommunications  systems  based   on  open,
standards-based,  client-server   architectures.    The   principal  functions
provided by the  Company's products  include connection to  and monitoring  of
public  switched  telephone networks  (PSTN),  call  switching, call  control,
recognition  and  generation  of  TouchTone  signals,  digital  recording  and
playback  of   transmissions,  and   integration  of  mixed   media  resources
(facsimile,   speech  recognition   and  text-to-speech)   and  computer-based
information.  The Company's  products are used in applications and  systems in
areas such as voice messaging, automated attendant, interactive voice response
(IVR), specialized switching, call centers and computer telephony integration,
call and  data recording,  voice-facsimile, wireless infrastructure,  and data
integration on local- and  wide-area networks (LANs and WANs).  Among examples
of these applications  are telephone banking,  medical alert and  prescription
services,  transaction  card  authorization,  telemarketing,  school  bulletin
boards, cellular  and other wireless switching  services, security monitoring,
and automated operator services.   

      The Company believes it has been and continues to be a technology leader
in computer telephony.   It  pioneered the  use of  digital signal  processing
chips  (DSPs) for PC-based computer telephony applications in the early 1980s.
In 1993, based  on its long experience  in using DSPs in combination  with its
own  proprietary  algorithms, the Company  introduced the Alliance  Generation
(AG)    product  line, which  the  Company  believes  is  the  most  powerful,
fully-featured,   PC-based enabling  technology currently  available.   The AG
product  line  is fully    compatible with  Multi-Vendor  Integration Protocol
(MVIP), a  widely-adopted  standard  for interoperability and  switching among
computer telephony  resources,  which  was introduced by  the Company in  1990
with the  support of  other industry   participants.  The  Company's Telephony

                                       3






Services Architecture  (TSA) provides  a   framework  in which  cost-effective
computer telephony and  telecommunications   products can form  the basis  for
high  value  applications  and  systems.    TSA  is    designed  to  be  open,
standards-based,   layered,   operating  system-independent,      modular  and
scaleable.  The Company's strategy is to expand  its business by concentrating
its  product  development and  marketing efforts in  market segments worldwide
which are  characterized by high value applications and systems.   The Company
offers a  broad range of enabling technology products for both the traditional
computer     telephony   markets  and   the  emerging   markets  in   wireless
infrastructure,  data  communications and mixed media.  Rather than attempting
to develop all such  enabling technologies with its own resources, the Company
designs  its  products   based  on  interoperability  with  standards and,  in
addition, enters into   development,  supply and  licensing arrangements  with
companies which have  developed complementary technologies.  In November 1995,
the  Company  substantially  increased its international  presence through its
acquisition of    VOX S.A.    (VOX),  one of  two  significant  European-based
suppliers of computer  telephony enabling technology products.  In  June 1996,
the  Company  acquired  Tek-Nique,  Inc.  and  PSR Systems,  Inc.,  affiliated
Illinois  corporations  (together  "TEKnique")  which develop  and  distribute
integrated hardware and software products for the Intelligent Network (IN) and
data communications markets.

      The Company pursues a leveraged distribution model whereby its customers
- --  original equipment  manufacturers  (OEMs), value  added resellers  (VARs),
systems     integrators,   telephony  service  providers,   and  international
distributors  --  incorporate  the  Company's  enabling  technology  into  the
products and services  they deliver to end-users.  Representative customers of
the  Company, and  the   types of  applications and  systems they  develop and
implement using  the  Company's enabling technology products, include: Alcatel
Business  Systems,     Centigram  Communications   Corporation  and   Wildfire
Communications,  Inc.   (voice   messaging);  Edify Corporation  (IVR); Aspect
Telecommunications Corporation    (call  centers);  France  Telecom  (enhanced
network services);  Allen Telecom   Group, Inc.  and  BellSouth Wireless, Inc.
(wireless  infrastructure);  Magnasync   Corporation  (specialized switching);
Kreutler GbmH (call and data recording);  Netcentric Corporation (LAN/WAN data
integration);  and  Cap  Sesa  Telecom  and    Nippon  Telephone  &  Telegraph
International (systems integrators/distributors).  The Company's products have
been incorporated into more than 425 products sold by more than 280 customers.

      The Company's principal executive  offices are located at 8  Erie Drive,
Natick, Massachusetts 01760-1339, and its telephone number is  (508) 650-1300.
The Company was incorporated in Delaware in 1983.   
                           ________________________

            AG, Alliance Generation , NaturalAccess,  Open Telecommunications,
Telephony  Services   Architecture  and   TSA  are  trademarks,   and  Natural
MicroSystems, VOX  and TEKnique are trade  names, of the Company  used in this
Prospectus.   Multi-Vendor Integration Protocol and MVIP are trademarks of GO-
MVIP, Inc.  This Prospectus  also includes references to trademarks and  trade
names of companies other than the Company.



                                       4






                                 RISK FACTORS

      In addition to the  other information contained in this  Prospectus, the
following factors should be  considered carefully in evaluating  an investment
in  the Common Stock  offered by  this Prospectus.   In  particular, potential
investors  are  advised  that statements contained herein  or incorporated  by 
reference into this  Prospectus  expressing  the  beliefs and  expectations of  
management regarding  the  Company's future results or performance are forward 
looking  statements  based  on  current expectations that involve a  number of  
risks and uncertainties.  The following factors describe certain  market risks  
associated with an  investment in  the Common Stock  and various of  the risks
and uncertainties  which could  cause actual results to differ materially from
management expectations.
  
      Variations in  Operating Results.   The Company's results  of operations
have varied from  quarter to  quarter and, in  recent quarters,  approximately
half  of the revenues have been received in the final month.  These variations
result  from a  number  of  factors,  including  timing  of  customer  orders,
adjustments  of  delivery  schedules  to accommodate  customer  or  regulatory
requirements, availability  of components from suppliers, timing  and level of
international  sales,  mix  of   products  sold,  and  timing  and   level  of
expenditures  for sales, marketing and  new product development.   The Company
has historically operated  with little  backlog and substantially  all of  its
revenues in each  quarter have resulted from orders  received in that quarter.
If short-term demand for the Company's products declines, or if the Company is
unable  to secure adequate materials from its suppliers, the Company's results
of operations for that quarter would  be adversely affected.  No assurance can
be  given that these  quarterly variations will  not occur in  the future and,
accordingly,  the results  of any  one quarter  may not  be indicative  of the
operating results for future quarters.  

      Competition.   The  market  for products  of the  type  supplied by  the
Company is highly  competitive.   The Company has  numerous competitors  whose
products compete with one or more of the  Company's products.  The products of
one  competitor, Dialogic Corporation, which  is significantly larger than the
Company  and has  significantly  greater resources  available  to it,  compete
directly against  the Company's full range of products.  As the Company enters
new markets, it expects to encounter competition from additional  competitors,
some  of whom  may have  greater  resources than  the Company.   In  addition,
certain large  applications and systems  developers use their  own proprietary
computer  telephony  enabling  components  as  an  alternative  to  purchasing
commercially available products such as those sold by the Company.  
      
      Market  Acceptance of Products;  Technological Changes.   The market for
the  Company's  products  is  characterized by  rapidly  changing  technology,
evolving  industry standards  and  frequent new  product  introductions.   The
Company's  near term success and future growth is substantially dependent upon
continuing  market acceptance of its  products.  The  Company's future success
will in  large part depend  on its continued  ability to enhance  its existing
products  and to develop new  products to meet  changing customer requirements
and  emerging industry standards.  There can  be no assurance that the Company
will  successfully  develop  new  products  and  enhancements,  including  its
NaturalAccess software  line, on  a timely  basis  or that  such products  and
enhancements will achieve  market acceptance.  Any delay in the development of

                                       5



                              
these  products and enhancements or their failure to achieve market acceptance
would adversely affect  the Company's business.  In addition,  there can be no
assurance  that products or technologies  developed by others  will not render
the  Company's  products  or technologies  noncompetitive  or  obsolete.   One
computer telephony industry standard  which has emerged over the  last several
years  is  Multi-Vendor  Integration  Protocol  (MVIP),  an  architecture  for
interoperability  and  switching,   of  which  the  Company  was  the  primary
developer.   Although a substantial  number of products  are based on  MVIP, a
competing architecture  for  interoperability, Dialogic  Corporation's  Signal
Computing  System  Architecture (SCSA),  has  been introduced  and  others may
emerge.   There can be no assurance that SCSA or another architecture will not
supersede MVIP, which could adversely affect the Company's business.

      Integration of VOX and TEKnique Operations.  The  successful integration
of the  operations  of VOX,   which  was  acquired in  November  1995, and  of
TEKnique,  which was  acquired in June  1966, with  those of  the Company will
require, among other things, the coordination of the product offerings  of the
Company  with those  of  VOX  and  TEKnique,  and  related  sales,  marketing,
development and administrative activities.  There can be no assurance that the
Company  will not  encounter unexpected  difficulties in such  integrations or
that the expected benefits will  be realized.  Any unexpected delays  or costs
incurred in  such integrations could  have a material adverse  effect upon the
Company.

      Limited Protection of  Proprietary Technology.  The Company's success is
dependent upon proprietary technology.   The Company currently has  no patents
and  protects its technology  primarily through copyrights  and trade secrets.
There can be no assurance that  the steps taken by the Company to  protect its
proprietary rights will  be adequate  to prevent the  misappropriation of  its
technology or  the independent  development by  others of  similar technology.
Although the Company believes that its products and technology do not infringe
on any existing  proprietary rights of others, there can  be no assurance that
third  parties  will  not assert  infringement  claims.    If infringement  is
alleged, there can be no assurance that the Company would prevail or that  any
necessary licenses would be available  on acceptable terms, if at all.  In any
event, patent  and  other intellectual  property litigation  can be  extremely
protracted and expensive.

      Dependence  on Market  Success of  Third Parties;  Significant Customer.
The Company's customers are primarily original equipment manufacturers (OEMs),
value  added   resellers  (VARs),   systems  integrators,  telephony   service
providers,  and  international  distributors.    The  Company's  revenues  are
dependent  upon  the ability  of its  customers to  develop and  sell computer
telephony  applications  and systems  to  end-users.   Factors  affecting  the
ability of the Company's customers to develop and sell their products  include
competition, regulatory restrictions,  patent and other  intellectual property
issues,  and  overall economic  conditions.   One  of the  Company's customers
accounted for 13.1%, 13.3% and  11.9% of the Company's revenues in  1993, 1994
and 1995, respectively.   There can  be no assurance  that this customer  will
continue to purchase similar volumes of the Company's products.  



                                       6






      Dependence  on Outside  Suppliers and  Contract Assembly  Manufacturers.
The Company relies on various suppliers  of components for its products.  Many
of  these  components  are  standard and  generally  available  from  multiple
sources.   However, certain custom integrated circuits and other devices which
are components  of one or more of  the Company's products are  acquired by the
Company from single source suppliers.  Although the Company believes  it could
develop other sources for each of these custom devices, the process could take
several months, and the inability or refusal of any such source to continue to
supply devices could have a material adverse effect on the Company pending the
development of an alternative source.  The Company also currently  relies on a
single  contract manufacturer to assemble  printed circuit boards  for each of
its  North  American  and European  operations.   Although  a  number  of such
contract manufacturers exist, the interruption or termination of the Company's
current manufacturing relationships could have a short-term adverse  effect on
the Company's business.  

      Risks Associated with International Operations.   The Company's sales to
customers  outside North America accounted for 43.2% of the Company's revenues
in  1995.  In addition,  the Company believes  that a material  portion of its
domestic sales ultimately result in the  use of the Company's products outside
North America.  Accordingly,  a significant portion of the  Company's revenues
are  subject to the risks associated  with international sales.  Subsequent to
the  Company's  acquisition  of VOX  in  November 1995,  the  Company  has had
significant  assets  denominated in  French  currency  and  has denominated  a
significant  portion of its sales  in foreign currencies.   Further, customers
generally  evaluate the  purchase  of products  of the  Company  based on  the
purchase  price expressed in the  customer's currency.   Therefore, changes in
foreign currency exchange rates may adversely affect the sale of the Company's
products.    The  Company  does  not  currently  engage  in  currency  hedging
transactions  to  offset the  risks  associated  with variations  in  currency
exchange rates.  In addition, international  markets have different regulatory
environments than those  of the United States, and the  Company is required to
obtain approval for its products prior to their use in other countries.  There
can be no  assurance that changes will not occur in  such regulations or that,
if  such changes  occur, the  Company will  be able  to continue  to  sell its
products  into the affected markets.  In addition, the Company's international
business may be  adversely affected  by risks such  as political  instability,
trade  and  tariff  regulations,  difficulty  in  obtaining  export  licenses,
difficulties or delays in collecting  accounts receivable, and difficulties in
staffing and managing international operations.  

      Possible  Volatility of Stock Price.   Factors such  as announcements of
technological  innovations or new products by the Company, its competitors and
other third parties, as well as quarterly variations in  the Company's results
of operations  and market  conditions in the  industry, may  cause the  market
price of the Common Stock to fluctuate significantly.  In  addition, the stock
market  in  general  has   recently  experienced  extreme  price  and   volume
fluctuations,  which have particularly affected the market prices of many high
technology  companies and  which have  often been  unrelated to  the operating
performance  of such companies.  These broad market fluctuations may adversely
affect the market price of the Common Stock.


                                       7






      Dependence on Key Personnel.  The Company is highly dependent on certain
key executive officers and technical employees,  the loss of any of whom could
have  an adverse impact on the future operations of the Company.  In addition,
the  Company may  need to  hire additional  skilled personnel  to support  the
continued  growth  of  its business  and  the  market  for skilled  personnel,
especially  those with  the technical  abilities required  by the  Company, is
currently  very competitive.  There can be  no assurance that the Company will
be  able  to retain  its existing  personnel  or attract  additional qualified
employees.  

      Certain Charter  Provisions with Anti-Takeover  and Other Effects.   The
Company's Board of Directors has the power to issue shares of Common Stock and
Preferred  Stock which, if issued,  could dilute and  adversely affect various
rights  of the  holders of  Common Stock  and, in  addition, could be  used to
discourage an  unsolicited attempt  to acquire  control of  the Company.   The
Company's Certificate of Incorporation also provides for a classified board of
directors  and  contains  other  provisions   which  may  also  discourage  an
unsolicited takeover attempt.   These  provisions could limit  the price  that
investors might be willing to pay in the future for shares of Common Stock and
could make it more difficult for stockholders of the Company to effect certain
corporate actions.

                                USE OF PROCEEDS

      The Company will  not receive any of  the proceeds from the  sale of the
Shares by the Selling Stockholders.



























                                       8






                             SELLING STOCKHOLDERS

      Set forth below, with respect to each Selling Stockholder, is the number
of shares of Common Stock beneficially owned as of August 22, 1996, the number
of Shares offered pursuant to this  Prospectus and the number of shares to  be
owned after  completion of the offering  (assuming the sale of  all the Shares
offered hereunder).  



                                                Number of     
                                                Shares to be  Number of Shares
                              Total Number of   Offered or    to be Owned After
 Name                         Shares Owned      Sold (1)      the Offering  (1)
 ----                         ---------------   ------------  -----------------
 
 Herbert L.  Pavey . . . .        18,678           9,339           9,339
 Julius M.  Rothschild . .        18,678           9,339           9,339
 John C.  Alexander  . . .         2,281           2,281               0
 Adam J.  Machalek . . . .           365             365               0
 Jeffrey M.  DeMent  . . .           365             365               0
 Joseph A.  Lee  . . . . .           290             290               0
 Jeffrey M.  Putnam  . . .           290             290               0
 Jeffrey T.  Rego  . . . .           290             290               0
 Stephen F. Witt . . . . .           124             124               0
 Tedd R.  Pierce . . . . .            41              41               0
 Celeste M.  Baril . . . .            25              25               0
 Michael A.  Firman  . . .            25              25               0
 Mark D. Davis . . . . . .            18              18               0
 Mary V. Hubner  . . . . .             9               9               0
                           
        (1)    Such Shares were issued by the Company  to  such   Selling
Stockholders  in  exchange  for  their  shares  of  the  common stock  of
Tek-Nique,  Inc., an Illinois corporation ("Tek-Nique"), on June 14, 1996
in connection with the merger of a wholly-owned subsidiary of the Company
with  and into Tek-Nique.  Tek-Nique  and  PSR  Systems,  Inc., which are
each  currently  wholly-owned  subsidiaries  of  the  Company  and  which
operate  a  single business  known  as  TEKnique,  were,  prior  to their
acquisition  by  the  Company,  under  common  ownership  by  the Selling 
Stockholders, each  of whom continues to be employed by TEKnique.


                             PLAN OF DISTRIBUTION

      The  Selling  Stockholders  and   their  agents,  donees,  distributees,
pledgees and  other successors in interest  may, from time to  time, offer for
sale and  sell or distribute the  Shares to be  offered by them hereby  (a) in
transactions  executed  on  the  Nasdaq  National Market,  or  any  securities
exchange  on which the shares may be traded, through registered broker-dealers
(who may act as principals, pledgees or agents) pursuant to unsolicited orders
or offers to buy, (b) in negotiated transactions, or (c)  through other means.
The Shares may be sold from time to time in one or more transactions at market
prices prevailing at  the time of sale or a fixed offering price, which may be
changed, or at  varying prices determined at the time of sale or at negotiated


                                       9



prices.   Such  prices will be  determined by  the Selling  Stockholders or by
agreement between  the Selling  Stockholders and their  underwriters, dealers,
brokers or agents.  The Shares may also be offered in one or more underwritten
offerings.   The underwriters  in an  underwritten offering,  if any,  and the
terms and conditions of any such offering will be described in a supplement to
this Prospectus.  

      In connection with distribution of  the Shares, the Selling Stockholders
may enter into  hedging or  other option transactions  with broker-dealers  in
connection with which, among  other things, such broker-dealers may  engage in
short sales of the Shares pursuant to this Prospectus in the course of hedging
the positions  they may assume with  one or more of  the Selling Stockholders.
The  Selling  Stockholders  may  also  sell  Shares  short  pursuant  to  this
Prospectus and  deliver the  Shares to  close out such  short positions.   The
Selling Stockholders may  also enter  into option or  other transactions  with
broker-dealers  which may result  in the  delivery of  Shares to  such broker-
dealers who  may sell such  Shares pursuant to  this Prospectus.   The Selling
Stockholders  may also pledge the  Shares to a  broker-dealer and upon default
the broker-dealer may effect the sales of the pledged Shares  pursuant to this
Prospectus.

      The  distribution of  the  Shares by  the  Selling Stockholders  is  not
subject  to any underwriting agreement.  Any underwriters, dealers, brokers or
agents   participating  in  the   distribution  of  the   Shares  may  receive
compensation in  the form of underwriting  discounts, concessions, commissions
or fees  from the Selling Stockholders  and/or purchasers of Shares,  for whom
they may  act.   Such  discounts, concessions,  commissions or  fees will  not
exceed those customary  for the type  of transactions involved.   In addition,
the Selling Stockholders and any such underwriters, dealers, brokers or agents
that  participate  in   the  distribution  of  Shares  may  be  deemed  to  be
underwriters  under the Securities Act, and any  profits on the sale of Shares
by them and any discounts, commissions  or concessions received by any of such
persons  may be deemed to be  underwriting discounts and commissions under the
Securities  Act.   Those who act  as underwriter,  broker, dealer  or agent in
connection  with the  sale  of the  Shares  will be  selected  by the  Selling
Stockholders  and may have other  business relationships with  the Company and
its subsidiaries  or affiliates  in the  ordinary course  of business.   Alex.
Brown & Sons  Incorporated, which acts as  a market maker with  respect to the
Common Stock,  has agreed to act as  a principal in purchasing  some or all of
the Shares from the Selling Stockholders and may thereafter resell such Shares
from time to time in or  through one or more transactions or  distributions on
the  Nasdaq  National Market,  through  other  registered  brokers or  dealers
pursuant to unsolicited  orders or  offers to buy,  in independent  negotiated
transactions, or otherwise.

      The aggregate  proceeds to the Selling Stockholders from the sale of the
Shares  offered by the Selling Stockholders hereby  will be the purchase price
of such Shares less any broker s commissions.

      In  order  to comply  with  the securities  laws  of certain  states, if
applicable,  the Shares  will  be  sold  in  such  jurisdiction  only  through
registered or licensed brokers or dealers.  In addition, in certain states the
Shares may not be  sold unless they have been registered or qualified for sale
in the applicable state or an exemption from the registration of qualification
requirement is available and is complied with.

                                      10



     The  Selling Stockholders  and any  broker-dealer, agent  or underwriter
that participates with  the Selling  Stockholders in the  distribution of  the
Shares may be deemed to be "underwriters" within the meaning of the Securities
Act, in which event any commissions received by such broker-dealers, agents or
underwriters and any profit on the resale of the Shares purchased  by them may
be deemed to  be underwriting  commissions or discounts  under the  Securities
Act.

      Under applicable  rules  and regulations  under  the Exchange  Act,  any
person  engaged  in the  distribution  of the  Shares offered  hereby  may not
simultaneously engage in market  making activities with respect to  the Shares
for  a  period of  two  business  days  prior  to  the  commencement  of  such
distribution.   In addition, and  without limiting the  foregoing, the Selling
Stockholders will be subject  to applicable provisions of the Exchange Act and
the  rules and  regulations thereunder,  including, without  limitation, Rules
10b-2, 10b-5, 10b-6 and 10b-7, which provisions may limit the  timing of sales
of the Shares by the Selling Stockholders.

      There is no assurance that the Selling Stockholders will sell any or all
of  the  Shares  described  herein  and may  transfer,  devise  or  gift  such
securities by other means not  described herein.  The Company is  permitted to
suspend the  use of this Prospectus in connection  with sales of the Shares by
holders during certain periods of time under certain circumstances relating to
pending  corporate developments  and public  filings  with the  Commission and
similar events.  Expenses  of preparing and filing the  registration statement
and any and all amendments thereto will be borne by the Company.

                    INTERESTS OF NAMED EXPERTS AND COUNSEL

      The legality of the Common Stock offered hereby is being passed upon for
the  Company by Choate, Hall  & Stewart (a  partnership including professional
corporations), Boston, Massachusetts.  Richard N.  Hoehn, a partner of Choate,
Hall & Stewart, is the Secretary of the Company.





















                                      11





                  No  dealer,  salesman   or  any
            other  person has  been authorized to
            give any  information or to make  any
            representations   not  contained   in
            this  Prospectus,  and,  if given  or                       
            made,     such     information     or
            representations  must not  be  relied                
            upon  as  having  been authorized  by  
            the    Company   or    any   of   the  
            Underwriters.   This Prospectus  does
            not   constitute  an   offer  of  any  
            securities other than those to  which
            it relates or an offer to  sell, or a
            solicitation of an offer  to buy,  to
            any person in any jurisdiction  where
            such  an offer  or solicitation would
            be  unlawful.   Neither  the delivery
            of  this  Prospectus  nor  any   sale  
            hereunder     shall,    under     any  
            circumstances,       create       any
            implication   that  the   information
            contained  herein  is  correct as  of
            any  time  subsequent  to  the   date
            hereof.

                                     
                           22,801 Shares                                    
                              
                              NATURAL 
                            MICROSYSTEMS
                            CORPORATION
            
                            Common Stock
                           
                             PROSPECTUS


                         September ___, 1996

                      
                      TABLE OF CONTENTS
                                             Page

            Available Information . . . . . .   2
            Incorporation  of  Certain  
            Documents by Reference  . . . . .   2
            The Company . . . . . . . . . . .   3
            Risk Factors  . . . . . . . . . .   5
            Use of Proceeds . . . . . . . . .   8
            Selling Stockholders  . . . . . .   9
            Plan of Distribution  . . . . . .   9
            Interests of Named Experts
             and Counsel  . . . . . . . . . .  11







                              PART II
              
              INFORMATION NOT REQUIRED IN PROSPECTUS

Item 14.  Other Expenses of Issuance and Distribution 

      The following table  sets forth the  costs and expenses  payable by  the
registrant  in  connection with  the  distribution  of  the  securities  being
registered  hereunder.   All of  the amounts  shown are estimates,  except the
Securities and Exchange Commission registration fee.

                   Securities and Exchange Commission 
                        Registration  Fee  . . . . . . . . . . . .  $  306.64 
                   Legal Fees and Expenses . . . . . . . . . . . .  $5,000.00   
                   Accountants' Fees and Expenses  . . . . . . . .  $1,000.00   
                                                                    ---------
                         Total . . . . . . . . . . . . . . . . . .  $6,306.64   
                                                                         



Item 15.  Indemnification of Directors and Officers

      Section 145  of the  General Corporation  Law of  the State  of Delaware
provides that a  corporation may  indemnify a director,  officer, employee  or
agent against  expenses (including attorneys' fees), judgments,  fines and for
amounts  paid in  settlement in  respect of  or in  successful defense  of any
action,  suit or  proceeding if  he acted  in good  faith and  in a  manner he
reasonably  believed to  be in or  not opposed  to the  best interests  of the
corporation, and, with  respect to any criminal  action or proceeding, had  no
reasonable cause to believe his conduct was unlawful.

      Article  Tenth   of  the   Company's  Fourth  Restated   Certificate  of
Incorporation provides that  no director  of the Company  shall be  personally
liable  to the Company or its stockholders  for monetary damages for breach of
fiduciary duty as a  director, except for liability (i) for  any breach of the
director's duty of  loyalty, (ii) for acts or  omissions not in good  faith or
which  involve intentional  misconduct or  a knowing  violation of  law, (iii)
under Section  174 of  the Delaware  General Corporation Law  or (iv)  for any
transaction  from which  the director  derived  an improper  personal benefit.
Article Tenth further provides  that a director's personal liability  shall be
eliminated or limited in the future  to the fullest extent permitted from time
to time by the Delaware General Corporation Law.

      Article  Eleventh  of  the  Company's  Fourth  Restated  Certificate  of
Incorporation provides that the Company shall, to the fullest extent permitted
from time to time under  the Delaware General Corporation Law, indemnify  each
of  its directors  and  officers against  all  expenses (including  attorneys'
fees), judgments,  fines and  amounts paid  in  settlement in  respect of  any
action,  suit or proceeding in which such  director or officer may be involved
or  with which he may be threatened,  while in office or thereafter, by reason

                                     II-1



             



of his or her actions or omissions in connection with services to the Company,
such indemnification to include prompt  payment of expenses in advance  of the
final disposition of any such action, suit or proceeding.


Item 16.  Exhibits

       *2.1  Articles  Fourth,  Seventh,   Twelfth  and   Thirteenth  of   the
             Registrant's Fourth Restated Certificate of Incorporation.
       *3.1  Articles II,  III,  IV,  V,  VII,  VIII,   XII  and  XXV  of  the
             Registrant's By-Laws. 
        4.1  Investment and Registration Rights Agreement dated as of June 14,
             1996.
        5.1  Opinion of Choate, Hall & Stewart as  to validity of shares being
             registered and Consent.
       23.1  Consent of KPMG Peat Marwick LLP.  
       23.2  Consent of Choate, Hall & Stewart (included in Exhibit 5.1).
       25.1  Power of Attorney (part of Signature Page).
_________________________

*  Filed as an exhibit to the registrant's  Registration Statement on Form S-1
(No.  33-27596)


Item 17.  Undertakings

   The undersigned registrant hereby undertakes:

      (1)  To file, during any period in which offers or sales are being made,
   a post-effective amendment to this Registration Statement:

            (i) To include any  material information with respect to  the plan
      of distribution  not previously disclosed in  the Registration Statement
      or  any  material   change  to  such  information  in  the  Registration
      Statement.

      (2)  That,  for  the purpose  of  determining  any  liability under  the
   Securities  Act of 1933, each such post-effective amendment shall be deemed
   to  be  a new  registration statement  relating  to the  securities offered
   therein,  and the offering of such securities  at that time shall be deemed
   to be the initial bona fide offering thereof.

      (3) To remove from  registration by means of a  post-effective amendment
   any  of  the  securities  being  registered  which  remain  unsold  at  the
   termination of the offering.

      The  undersigned  registrant hereby  undertakes  that,  for purposes  of
determining any liability under the Securities Act of 1933, each filing of the
registrant's annual report pursuant to  section 13(a) or section 15(d) of  the
Securities  Exchange Act  of 1934 (and,  where applicable,  each filing  of an
employee  benefit  plan's  annual report  pursuant  to  Section  15(d) of  the
Securities  Exchange Act  of 1934)  that is  incorporated by reference  in the
Registration  Statement shall  be deemed  to be  a new  registration statement

                                     II-2





relating  to  the  securities  offered  therein,  and  the  offering  of  such
securities at that time shall be  deemed to be the initial bona  fide offering
thereof.

      The undersigned registrant hereby undertakes that:

      (1)   For purposes of determining any liability under the Securities Act
of 1933, the information omitted from the form of prospectus filed as part  of
this Registration Statement in reliance upon Rule 430A and contained in a form
of prospectus filed  by the registrant pursuant  to Rule 424(b)(1) or (4),  or
497(h)  under  the  Securities  Act  shall  be  deemed  to  be  part  of  this
Registration Statement as of the time it was declared effective.

      (2)   For the purpose of determining any liability under  the Securities
Act of 1933, each post-effective amendment  that contains a form of prospectus
shall be deemed to be a new registration statement relating  to the securities
offered therein,  and the offering  of such securities  at that time  shall be
deemed to be the initial bona fide offering thereof.

      Insofar as  indemnification of liabilities arising  under the Securities
Act of 1933 may be permitted to directors, officers and controlling persons of
the registrant  pursuant to the  provisions described under Item  15 above, or
otherwise,  the  registrant has  been  advised  that  in the  opinion  of  the
Securities  and Exchange  Commission  such indemnification  is against  public
policy as expressed in the Act and is, therefore, unenforceable.  In the event
that  a claim  for indemnification  against such  liabilities (other  than the
payment by  the registrant of expenses incurred or paid by a director, officer
or controlling  person of  the  registrant in  the successful  defense of  any
action,  suit  or  proceeding)  is  asserted  by  such  director,  officer  or
controlling  person in connection with any of the securities being registered,
the registrant will, unless in the opinion of its counsel the  matter has been
settled  by   controlling  precedent,  submit   to  a  court   of  appropriate
jurisdiction the question whether such indemnification by it is against public
policy as expressed in the Act and will be governed by the final  adjudication
of such issue.



















                                     II-3





                                  SIGNATURES

   Pursuant to the  requirements of  the Securities Act  of 1933, the  Company
certifies that it has  reasonable grounds to believe that it  meets all of the
requirements for  filing  a Form  S-3 and  has duly  caused this  Registration
Statement  to  be signed  on  its behalf  by  the undersigned,  thereunto duly
authorized, in the Town of Natick, The Commonwealth of Massachusetts on August
23, 1996.


                              Natural MicroSystems Corporation
                              (Issuer and Employer)

                              By: /s/ Robert P. Schechter
                              Robert P. Schechter, President
                              and Chief Executive Officer






































                                     II-4



                               
                               
                               POWER OF ATTORNEY

   KNOW  ALL MEN  BY  THESE PRESENTS,  that  each individual  whose  signature
appears below constitutes and appoints Robert P.  Schechter, John  F.  Kennedy
and Richard N.   Hoehn, jointly and severally, his  true and lawful attorneys-
in-fact and  agents with full powers of substitution, for him and in his name,
place and  stead, in any  and all capacities, to  sign any and  all amendments
(including post-effective  amendments) to this registration  statement, and to
file the  same, with  all exhibits  thereto, and all  documents in  connection
therewith, with the  Securities and  Exchange Commission,  granting unto  said
attorneys-in-fact and agents, and each of them, full power and authority to do
and perform each and every act and thing requisite  and necessary to be in and
about the premises, as fully to all intents and purposes as he might  or could
do  in person, hereby ratifying and confirming all that said attorneys-in-fact
and agents, or  any of them,  or their or his  substitute or substitutes,  may
lawfully do or cause to be done by virtue thereof.

   Pursuant   to  the  requirements  of  the  Securities  Act  of  1933,  this
registration  statement has been  signed below on  the dates indicated  by the
following persons in the capacities indicated.

Name                               Capacity                            Date


/s/ Robert P. Schechter            President, Chief Executive          8/23/96
Robert P. Schechter                Officer and Director
                                   (Principal Executive Officer)

/s/ John F. Kennedy                Chief Financial Officer             8/23/96
John F. Kennedy                    (Principal Financial Officer)

/s/ David C. Flynn                 Controller                          8/23/96
David C. Flynn                     (Principal Accounting Officer)

/s/ Charles T. Foskett             Director                            8/23/96
Charles T. Foskett

/s/ David F. Millet                Director                            8/19/96
David F. Millet

/s/ Ronald W. White                Director                            8/23/96
Ronald W. White

/s/ C. William McDaniel           Director                            8/23/96
C. William McDaniel


                                     
                                     II-5




                                              Exhibit 4.1

           INVESTMENT AND REGISTRATION RIGHTS AGREEMENT

     This Agreement is made as of June 14, 1996, by and among
Natural MicroSystems Corporation, a Delaware corporation ("NMS"),
Tek-Nique, Inc., an Illinois corporation ("TEKnique") and the
individuals signatory hereto (the "TEKnique Stockholders"), who
collectively own all of the outstanding shares of capital stock
of TEKnique.

     WHEREAS, pursuant to a Merger Agreement and Plan of
Reorganization by and among NMS, TEKnique and the TEKnique
Stockholders dated as of this date (the "Merger Agreement";
capitalized terms used herein without definition shall have the
meanings given them in the Merger Agreement"), NMS will acquire
all of the outstanding capital stock of TEKnique through a merger
of a subsidiary of NMS with and into TEKnique; and

     WHEREAS, the Merger Agreement provides that NMS will issue
shares of its common stock to the TEKnique Stockholders in
consideration for NMS' acquisition of the stock of TEKnique; and

     WHEREAS, it is a condition to the closing under the Merger
Agreement that NMS, TEKnique and the TEKnique Stockholders enter
into this Agreement.

     NOW, THEREFORE, in consideration of the mutual covenants set
forth herein, the parties hereto agree as follows:

1.   Certain Definitions.

     As used in this Agreement, the following terms shall have
the following respective meanings:

     (a)  "Commission" shall mean the Securities and Exchange
Commission or any other federal agency at the time administering
the Securities Act.

     (b)  "Exchange Act" shall mean the Securities Exchange Act
of 1934, as amended, or any similar federal statute, and the
rules and regulations of the Commission thereunder, all as the
same shall be in effect at the time.

     (c)  "Holder" shall mean any holder of Restricted
Securities.

     (d)   The terms "register," "registered" and "registration"
all refer to a registration effected by preparing and filing a
registration statement in compliance with the Securities Act
("registration statement"), and the declaration or ordering of
the effectiveness of such registration statement.





     (e)  "Restricted Securities" shall mean the NMS Shares
issued to the TEKnique Stockholders pursuant to the Merger
Agreement (including if any, the Contingent Shares) and any other
NMS Shares issued in respect of such shares upon subdivisions,
combinations, stock dividends, reclassifications,
recapitalizations or similar events, or any other shares of
capital stock issued in exchange for or in replacement of the NMS
Shares in a merger or otherwise.

     (f)  "Registrable Securities" shall have the meaning set
forth in the preface of Section 3 below. 

     (g)  "Registration Expenses" shall mean all expenses
incurred by NMS in complying with its obligations under Sections
3 and 4 of this Agreement, including, without limitation, all
federal and state registration, qualification and filing fees,
printing expenses, fees and disbursements of counsel for NMS,
blue sky fees and expenses, and the expense of any special audits
incident to or required by any such registration.

     (g)  "Securities Act" shall mean the Securities Act of 1933,
as amended, or any similar federal statute, and the rules and
regulations of the Commission thereunder, all as the same shall
be in effect at the time.

     (h)  "Selling Expenses" shall mean all selling commissions
and fees and disbursements of counsel for the Holders applicable
to the sale of Restricted Securities pursuant to this Agreement.

2.   Restrictions on Transferability; Investment Representations.

     2.1  Restrictions. The Restricted Securities shall not be
sold, assigned, transferred or pledged except upon the conditions
specified in this Section 2, which conditions are intended to
ensure compliance with the provisions of the Securities Act. 
Each Holder will cause any proposed purchaser, assignee,
transferee, or pledgee of the Restricted Securities held by the
Holder to agree to take and hold such securities subject to the
provisions and upon the conditions specified in this Section 2.

     2.2  Restrictive Legend.  TEKnique and each of the TEKnique
Stockholders understand and acknowledge that the Restricted
Securities have not been registered under the Securities Act, or
under any applicable blue sky or state securities law, on the
grounds that the offering and sale of the Restricted Securities
pursuant to the Merger Agreement are exempt from registration
pursuant to Section 4(2) of the Securities Act and are exempt
from qualification pursuant to exemptions available under state
securities laws, and that NMS's reliance upon such exemptions is
predicated in part upon the representations of TEKnique and each
TEKnique Stockholder set forth in this Agreement.  TEKnique and
each TEKnique Stockholder acknowledge and understand that the

DS1:268694                     -- 2 --






Restricted Securities acquired by TEKnique and each TEKnique
Stockholder must be held indefinitely unless such Restricted
Securities are subsequently registered under the Securities Act
and applicable blue sky and state securities laws or unless an
exemption from such registration is available.  Each certificate
representing the Restricted Securities (unless otherwise
permitted by the provisions of Section 2.3 below) shall be
stamped or otherwise imprinted with a legend in the following
form (in addition to any legend required under applicable state
securities laws):

     THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE BEEN
     ACQUIRED FOR INVESTMENT AND HAVE NOT BEEN REGISTERED UNDER
     THE SECURITIES ACT OF 1933.  SUCH SHARES MAY NOT BE SOLD OR
     TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION OR UNLESS
     NMS RECEIVES AT ITS REQUEST AN OPINION OF COUNSEL REASONABLY
     ACCEPTABLE TO IT STATING THAT SUCH SALE OR TRANSFER IS
     EXEMPT FROM THE REGISTRATION AND PROSPECTUS DELIVERY
     REQUIREMENTS OF SAID ACT.  COPIES OF THE AGREEMENTS COVERING
     THE ACQUISITION OF THESE SHARES AND RESTRICTING THEIR
     TRANSFER MAY BE OBTAINED AT NO COST BY WRITTEN REQUEST MADE
     BY THE HOLDER OF RECORD OF THIS CERTIFICATE TO THE SECRETARY
     OF NMS AT THE PRINCIPAL EXECUTIVE OFFICES OF NMS.

NMS shall be entitled to make a notation on its records and give
instructions to any transfer agent of the Restricted Securities
in order to implement the restrictions on transfer established in
this Section 2.

     2.3  Notice of Proposed Transfers.  Prior to any proposed
sale, assignment, transfer or pledge of any Restricted
Securities, unless there is in effect a registration statement
under the Securities Act covering the proposed transfer, the
Holder thereof shall give written notice to NMS of such Holder's
intention to effect such transfer, sale, assignment or pledge. 
Each such notice shall describe the manner and circumstances of
the proposed transfer, sale, assignment or pledge in sufficient
detail, and, if requested by NMS, shall be accompanied, at such
Holder's expense, by either (i) a written opinion of legal
counsel who shall be, and whose legal opinion shall be,
reasonably satisfactory to NMS, addressed to NMS, to the effect
that the proposed transfer of the Restricted Securities may be
effected without registration under the Securities Act, or (ii) a
"no action" letter from the Commission to the effect that the
transfer of such securities without registration will not result
in a recommendation by the staff of the Commission that action be
taken with respect thereto, whereupon the Holder of such
Restricted Securities shall transfer such Restricted Securities
in accordance with the notice delivered by the Holder to NMS.  No
such notice or opinion of counsel shall be required in connection
with any distribution of the Restricted Securities by TEKnique to
the TEKnique Stockholders.  NMS will not require an opinion of

DS1:268694                     -- 3 --






counsel for transactions made in reliance on Rule 144 under the
Securities Act except in unusual circumstances, the existence of
which shall be determined in good faith by the Board of Directors
of NMS.  Each certificate evidencing the Restricted Securities
transferred as provided above shall bear, except if such transfer
is made pursuant to an effective registration statement under the
Securities Act or Rule 144, the appropriate restrictive legend
set forth in Section 2.2 above, except that such certificate
shall not bear such restrictive legend if in the opinion of
counsel for such Holder and NMS such legend is not required in
order to establish compliance with any provision of the
Securities Act.

     2.4  Investment Representations.  TEKnique and each TEKnique
Stockholder respectively represent and warrant to NMS that it or
such stockholder is or will be acquiring the Restricted
Securities for its or such stockholder's own account for
investment purposes only and not with a view to distribution
(other than a distribution by TEKnique to the TEKnique
Stockholders).  Each TEKnique Stockholder also respectively
represents and warrants that such stockholder (a) has such
knowledge and experience in financial and business matters,
either alone or with advisors, that such stockholder is capable
of evaluating the merits and risks of acquiring the Restricted
Securities; (b) has the ability to bear the economic risks of
ownership of the Restricted Securities; (c) has been furnished
copies of the following: (i) NMS's annual report to stockholders
for 1995, (ii) NMS's definitive proxy statement filed with the
Commission in connection with its 1996 annual meeting of
stockholders, (iii) NMS's annual report on Form 10-K for 1995 and
its quarterly report on Form 10-Q for the quarter ended March 31,
1996, each as filed with the Commission, (iv) any other reports
or documents filed by NMS with the Commission since such annual
report on Form 10-K, and (v) a brief description of the
Restricted Securities and any material changes in NMS's affairs
that are not disclosed in the documents furnished; and (d) has
had the opportunity to ask questions and receive answers
concerning NMS, the Merger Agreement and the transaction
contemplated thereby, the Restricted Securities and to obtain any
additional information which NMS possesses or can acquire without
unreasonable effort or expense that is necessary to verify the
accuracy of the other information furnished.

3.   Registration and Sale.  Not later than 90 days following the
date hereof, NMS shall prepare and file with the Commission a
registration statement on Form S-3 covering the sale by the
Holders of the Restricted Securities (but excluding fifty percent
of the shares issued to each of the Major Stockholders at the
Closing) issued to the Holders (the "Registrable Securities");
provided, however that if NMS shall furnish to the Holders a
certificate signed by the President of NMS stating that in the
good faith judgment of the Board of Directors it would be

DS1:268694                     -- 4 --






seriously detrimental to NMS or its stockholders for a
registration statement to be filed in the near future, then NMS's
obligation to file such registration statement shall be deferred
for a period not to exceed 90 days from the date such certificate
is furnished to the Holders.

     (a)  Obligations of NMS. In connection with such
registration statement, NMS will:

          (i)  use its best efforts to cause such registration
     statement to become effective as soon as is practicable and
     to remain effective until all Registrable Securities have
     been sold, but in no event shall NMS be obligated to use its
     best efforts to cause such registration statement to remain
     effective as to any Registrable Securities beyond the second
     anniversary (or the first anniversary if Rule 144 is amended
     to permit sales of restricted stock thereunder after one
     year) of the date of the issuance thereof;

          (ii) furnish to the Holders such reasonable number of
     copies of the registration statement, preliminary
     prospectus, final prospectus and such other documents as
     they may reasonably request in order to facilitate the
     public offering of such securities;

          (iii)     prepare and file with the Commission such
     amendments and supplements to such registration statement
     and the prospectus used in connection with such registration
     statement as may be necessary to comply with the provisions
     of the Securities Act with respect to the disposition of all
     Registrable Securities;

          (iv) use its best efforts to register and qualify the
     Registrable Securities covered by such registration
     statement under such other securities or blue sky laws of
     such jurisdictions as shall be reasonably requested by the
     Holders, provided that NMS shall not be required in
     connection therewith or as a condition thereto to file a
     general consent to service of process in any such states or
     jurisdictions; and

          (v)  keep each Holder advised in writing as to the
     status of such registration statement and related blue sky
     law qualifications.

     (b)  Obligations of the Holders.  In connection with such
registration statement, each Holder will:

          (i)  furnish to NMS such information regarding such
     Holder, the Restricted Securities and any other NMS Shares
     beneficially held by him or her, and the distribution
     proposed by such Holder as NMS may reasonably request in

DS1:268694                     -- 5 --






     writing and as shall be required in connection with any
     registration, qualification or compliance referred to in
     this Agreement; and

          (ii) if, after a registration statement becomes
     effective, NMS advises the holders of Registrable Securities
     that NMS considers it appropriate for the registration
     statement to be amended, the Holders of such shares shall
     suspend any further sales of their Registrable Securities
     until NMS advises them that the registration statement has
     been amended.

     (c)  Expenses.  All Registration Expenses incurred in
connection with the registration pursuant to this Agreement shall
be borne by NMS.  All Selling Expenses shall be borne by the
respective Holder selling the Registrable Securities.

4.   Reports Under Exchange Act.

     With a view to making available to the Holders the benefits
of Rule 144 under the Securities Act and any other rule or
regulation of the Commission that may at any time permit a Holder
to sell Restricted Securities to the public without registration
or pursuant to a registration on Form S-3, if applicable, NMS
agrees, so long as any Restricted Securities shall be held by any
Holders, to use its best efforts to:

     (a)  make and keep public information available, as those
terms are understood and defined in Rule 144;

     (b)  file with the Commission in a timely manner all reports
and other documents required of NMS under the Securities Act and
the Exchange Act;

     (c)  list all Restricted Securities on such securities
exchanges as the Common Stock of NMS is listed; and

     (d)  furnish to any Holder, so long as such Holder owns any
Restricted Securities, forthwith upon written request (i) a
written statement by NMS that it has complied with the reporting
requirements set forth in subparagraph (c)(1) of Rule 144, the
Securities Act and the Exchange Act, or that it qualifies as a
registrant whose securities may be resold pursuant to a
registration statement on Form S-3, (ii) a copy of the most
recent annual or quarterly report of NMS and such other reports
and documents filed by NMS with the Commission, and (iii) such
other information (but not any opinion of counsel) as may be
reasonably requested by any Holder seeking to avail  himself or
herself of any rule or regulation of the Commission which permits
the selling of any Restricted Securities without registration or
pursuant to Form S-3.  NMS hereby represents and warrants that as


DS1:268694                     -- 6 --






of the date hereof it qualifies as a registrant whose securities
may be resold pursuant to a registration statement on Form S-3.

5.   Indemnification.

     5.1   NMS Indemnification of Holders.  NMS will indemnify
each Holder, each of such Holder's officers and directors and
partners, and each person controlling such Holder within the
meaning of Section 15 of the Securities Act, with respect to
which registration, qualification or compliance has been effected
pursuant to this Agreement, and each underwriter, if any, and
each person who controls any underwriter within the meaning of
Section 15 of the Securities Act, against all expenses, claims,
losses, damages or liabilities (or actions in respect thereof),
including any of the foregoing incurred in settlement of any
litigation, commenced or threatened, arising out of or based on
any untrue statement (or alleged untrue statement) of a material
fact contained in any registration statement, prospectus,
offering circular or other document, or any amendment or
supplement thereto, incident to any such registration,
qualification or compliance, or based on any omission (or alleged
omission) to state therein a material fact required to be stated
therein or necessary to make the statements therein, in light of
the circumstances in which they were made, not misleading, or any
violation by NMS of the Securities Act or any rule or regulation
promulgated under the Securities Act applicable to NMS in
connection with any such registration, qualification or
compliance, and NMS will reimburse each such Holder, each of its
officers and directors, and each person controlling such Holder,
each such underwriter and each person who controls any such
underwriter, for any legal and any other expenses reasonably
incurred in connection with investigating, preparing or defending
any such claim, loss, damage, liability or action, provided that
NMS will not be liable in any such case to the extent that any
such claim, loss, damage,, liability or expense arises out of or
is based on any untrue statement or omission or alleged untrue
statement or omission, made in reliance upon and in conformity
with written information furnished to NMS by an instrument duly
executed by such Holder, controlling person or underwriter, as
the case may be, and stated to be specifically for use therein.

     5.2   Holders' Indemnification of NMS.  Each Holder will
indemnify NMS, each of its directors and officers, each
underwriter, if any, of NMS's securities covered by such a
registration statement, each person who controls NMS or such
underwriter within the meaning of Section 15 of the Securities
Act, and each other such Holder, each of its officers and
directors and each person controlling such Holder within the
meaning of Section 15 of the Securities Act, against all claims,
losses, damages and liabilities (or actions in respect thereof)
arising out of or based on any untrue statement (or alleged
untrue statement) of a material fact contained in any such

DS1:268694                     -- 7 --






registration statement, prospectus, offering circular or other
document, or any omission (or alleged omission) to state therein
a material fact required to be stated therein or necessary to
make the statements therein not misleading, and will reimburse
NMS, such Holders, such directors, officers, persons,
underwriters or control persons for any legal or any other
expenses reasonably incurred in connection with investigating or
defending any such claim, loss, damage, liability or action, in
each case to the extent, but only to the extent, that such untrue
statement (or alleged untrue statement) or omission (or alleged
omission) is made in such registration statement, prospectus,
offering circular or other document in reliance upon and in
conformity with written information furnished to NMS by an
instrument duly executed by such Holder and stated to be
specifically for use therein.  Notwithstanding the foregoing, the
liability of each Holder under this subsection (b) shall be
limited in an amount equal to the public offering price of the
shares sold by such Holder, provided, however, subject to such
limitation on the amount of money damages, the provisions of this
sentence shall not limit or restrict any other right or action of
NMS against the Holders arising out of any such untrue statement
or omission contained in any registration statement, prospectus,
offering circular or other documents in reliance upon and in
conformity with written information furnished to NMS by such
Holder in the manner described hereinabove.

     5.3  Procedures. Each party entitled to indemnification
under this Section 5 (the "Indemnified Party") shall give notice
to the party required to provide indemnification (the
"Indemnifying Party") promptly after such Indemnified Party has
actual knowledge of any claim as to which indemnity may be
sought, and shall permit the Indemnifying Party to assume the
defense of any such claim or any litigation resulting therefrom,
provided that counsel for the Indemnifying Party, who shall
conduct the defense of such claim or litigation, shall be
approved by the Indemnified Party (whose approval shall not
unreasonably be withheld), and the Indemnified Party may
participate in such defense at such party's expense, and provided
further that the failure of any Indemnified Party to give notice
as provided herein shall not relieve the Indemnifying Party of
its obligations under this Section 5 unless the failure to give
such notice is materially prejudicial to an Indemnifying Party's
ability to defend such action and provided further, that the
Indemnifying Party shall not assume the defense for matters as to
which there is a conflict of interest or separate and different
defenses.  No Indemnifying Party, in the defense of any such
claim or litigation, shall, except with the consent of each
Indemnified Party, consent to entry of any judgment or enter into
any settlement which does not include as an unconditional term
thereof the giving by the claimant or plaintiff to such
Indemnified Party of a release from all liability in respect to
such claim or litigation.  No Indemnifying Party shall be liable

DS1:268694                     -- 8 --






for indemnification hereunder with respect to any settlement or
consent to judgment, in connection with any claim or litigation
to which these indemnification provisions apply, that has been
entered into without the prior consent of the Indemnifying Party
(which consent will not be unreasonably withheld).

     5.4  Legal Expenses.  In the event of any indemnification
hereunder, the Indemnifying Party shall pay the reasonable fees
and expenses of counsel for the Indemnified Party or Parties in
connection with the claim or litigation to which such
indemnification applies.

6.   Transfer of Registration Rights.

     The rights of a Holder under this Agreement may be assigned
to a transferee or assignee acceptable to NMS, which acceptance
shall not be unreasonably withheld, in connection with any
transfer or assignment of Registrable Securities by a Holder
provided that: (i) such transfer may otherwise be effected in
accordance with applicable securities laws, and (ii) such
assignee or transferee acquires at least 20% of the transferring
Holder's Registrable Securities; provided, however, that NMS must
be given written notice prior to the time of said transfer,
stating the name and address of said transferee or assignee and
identifying the securities with respect to which such
registration rights are being assigned. 

7.   Miscellaneous.

     7.1  Governing Law.  This Agreement shall be governed by and
construed in accordance with the laws of The Commonwealth of
Massachusetts applicable to contracts entered into and wholly to
be performed within The Commonwealth of Massachusetts.

     7.2  Counterparts. This Agreement may be executed in two or
more counterparts, each of which shall be deemed an original, but
all of which together shall constitute one and the same
instrument.

     7.3  Headings. The headings of the Sections of this
Agreement are for convenience and shall not by themselves
determine the interpretation of this Agreement.

     7.4  Notices.  Any notice required or permitted hereunder
shall be given in writing and shall be conclusively deemed effec-
tively given upon personal delivery, or three days after deposit
in the United States mail, by registered or certified mail (or by
airmail, if notice shall be sent outside the United States),
postage prepaid, addressed (a) if to NMS, at its principal
executive office, attention: President, and (b) if to a Holder at
such address as shall be the address of record of the Holder on


DS1:268694                     -- 9 --






the registry of NMS, or at such other address as any Holder may
designate in accordance with the terms hereof.

     7.5  Amendment of Agreement.  This Agreement may be amended
only by a written instrument signed by NMS and by persons holding
at least a majority of the Restricted Securities.















































DS1:268694                     -- 10 --






     IN WITNESS WHEREOF, the parties hereto have executed this
Agreement as of the day and year first above written.

STOCKHOLDERS:                     NATURAL MICROSYSTEMS
                                  CORPORATION

     *                            By: /s/ John F. Kennedy
_________________________         Its: Chief Financial Officer
John Alexander                   
                                 
     *
_________________________
Celeste Baril
                                 TEK-NIQUE, INC.
     *         
_________________________
Mark Davis                       By: Herbert Pavey
                                 Its: Vice President
     *          
_______________________
Jeff Dement
                                 *By: Tek-Nique, Inc.
     *                           Attorney-in-Fact Under Power
_________________________        of Attorney granted June 14, 1996
Michael Firman
                                 By: /s/ Herbert Pavey
     *                           Its: Vice President
_________________________
Mary Hubner

     *        
_________________________
Joe Lee

     *        
_________________________
Adam Machalek


/s/ Herbert Pavey

     *
_________________________
Tedd Pierce

     *       
_________________________
Jeff Putnam


     * 
_________________________
Jeff Rego

DS1:268694                     -- 11 --





/s/ Julius Rothschild


     *
________________________
Steve Witt














































                                   -- 12 --



                                                          Exhibit 5.1

                            CHOATE, HALL & STEWART
               A PARTNERSHIP INCLUDING PROFESSIONAL CORPORATIONS
                                EXCHANGE PLACE
                                53 STATE STREET
                       BOSTON, MASSACHUSETTS 02109-2891
                            TELEPHONE (617)248-5000
                           FACSIMILE (617) 248-4000
                                TELEX 49615860





                                          August 29, 1996

Natural MicroSystems Corporation
8 Erie Drive
Natick, Massachusetts 01760-1339

Gentlemen:

      This opinion is delivered to you in connection with the registration
statement on Form S-3 (the "Registration Statement") to be filed on or about
August 29, 1996 by Natural MicroSystems Corporation (the "Company") under the
Securities Act of 1933, as amended, for registration under said Act of 22,801
shares of common stock, $.01 par value (the "Common Stock"), of the Company.

      We are familiar with the Company's Certificate of Incorporation, as
amended, its By-Laws, as amended, and the records of its corporate
proceedings.  We have also examined such other documents, records and
certificates and made such further investigation as we have deemed necessary
for the purposes of this opinion.

      Based upon and subject to the foregoing, we are of the opinion that the
shares of Common Stock to be sold by the Selling Stockholders pursuant to the
Registration Statement have been legally issued, fully paid and nonassessable.

      We understand that this opinion is to be used in connection with the
Registration Statement and consent to the filing of this opinion as an exhibit
to the Registration Statement.  We further consent to the reference to this
firm in the section entitled "Interests of Named Experts and Counsel" in the
Registration Statement.

                                          Very truly yours,
                                                                

                                          CHOATE, HALL & STEWART







                                                         Exhibit 23.1


                               AUDITOR'S CONSENT

The Board of Directors
Natural MicroSystems Corporation

We consent to incorporation by reference in this registration statement on
Form S-3 of Natural MicroSystems Corporation of our report dated January 22,
1996, relating to the consolidated balance sheets of Natural MicroSystems
Corporation as of December 31, 1995 and 1994 and the related consolidated
statements of operations, stockholders' equity, and cash flow for each of the
years in the three-year period ended December 31, 1995, and all related
schedules, which report appears in the December 31, 1995 annual report on Form
10-K of Natural MicroSystems Corporation.



                                          KPMG PEAT MARWICK LLP


Boston, MA
August 26, 1996







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