NATURAL MICROSYSTEMS CORP
SC 13G/A, 1998-11-20
TELEPHONE & TELEGRAPH APPARATUS
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SECURITIES & EXCHANGE COMMISSION
Washington, D.C. 20549
______________________

SCHEDULE 13G*
(Rule 13d-102)

INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT 
TO RULES 13d-1(b), (c) AND (d) AND AMENDMENTS THERETO FILED 
PURSUANT TO 13d-2(b)
(Amendment No. 1)

Natural Microsystems Corporation
(Name of Issuer)

Common Stock
(Title of Class of Securities)

638882100
(CUSIP Number)

November 4, 1998
(Date of event which requires filing of this statement)


     Check the appropriate box to designate the rule pursuant to which this 
Schedule 13G is filed:
     [ ]  Rule 13d-1(b)
     [X]  Rule 13d-1(c)
     [ ]  Rule 13d-1(d)





                           (Page 1 of 12 Pages)
________________
     *The remainder of this cover page shall be filled out for a reporting 
person's initial filing on this form with respect to the subject class of 
securities, and for any subsequent amendment containing information which 
would alter the disclosures provided in a prior cover page.

     The information required in the remainder of this cover page shall not be 
deemed to be "filed" for purposes of Section 18 of the Securities Exchange Act 
of 1934 ("Act") or otherwise subject to the liabilities of that section of the 
Act but shall be subject to all other provisions of the Act (however, see the 
Notes)


CUSIP No. 638882100                 13G                    Page 2 of 12 Pages

____________________________________________________________________________
     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. 
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Lone Spruce, L.P.
_____________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                                  (a)  [X] 
                                                                  (b)  [ ] 
_____________________________________________________________________________
     (3)    SEC USE ONLY 
_____________________________________________________________________________
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
_____________________________________________________________________________
NUMBER OF      (5)  SOLE VOTING POWER 
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                 10,711
OWNED BY       ___________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER 
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER 
                                                 10,711
_____________________________________________________________________________
     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON 
                                                 10,711
_____________________________________________________________________________
     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ] 
_____________________________________________________________________________
     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)           
                                                0.1%
_____________________________________________________________________________
     (12)    TYPE OF REPORTING PERSON **
                                                 PN
_____________________________________________________________________________
                    ** SEE INSTRUCTIONS BEFORE FILLING OUT!


CUSIP No. 638882100                 13G                    Page 3 of 12 Pages

____________________________________________________________________________
     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. 
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Lone Balsam, L.P.
_____________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                                  (a)  [X] 
                                                                  (b)  [ ] 
_____________________________________________________________________________
     (3)    SEC USE ONLY 
_____________________________________________________________________________
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
_____________________________________________________________________________
NUMBER OF      (5)  SOLE VOTING POWER 
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                 28,067
OWNED BY       ___________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER 
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER 
                                                 28,067
_____________________________________________________________________________
     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON 
                                                 28,067
_____________________________________________________________________________
     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ] 
_____________________________________________________________________________
     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)           
                                                0.3%
_____________________________________________________________________________
     (12)    TYPE OF REPORTING PERSON **
                                                 PN
_____________________________________________________________________________
                    ** SEE INSTRUCTIONS BEFORE FILLING OUT!


CUSIP No. 638882100                 13G                    Page 4 of 12 Pages

____________________________________________________________________________
     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. 
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Lone Sequoia, L.P.
_____________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                                  (a)  [X] 
                                                                  (b)  [ ] 
_____________________________________________________________________________
     (3)    SEC USE ONLY 
_____________________________________________________________________________
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
_____________________________________________________________________________
NUMBER OF      (5)  SOLE VOTING POWER 
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                 28,068
OWNED BY       ___________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER 
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER 
                                                 28,068
_____________________________________________________________________________
     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON 
                                                 28,068
_____________________________________________________________________________
     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ] 
_____________________________________________________________________________
     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)           
                                                0.3%
_____________________________________________________________________________
     (12)    TYPE OF REPORTING PERSON **
                                                 PN
_____________________________________________________________________________
                    ** SEE INSTRUCTIONS BEFORE FILLING OUT!


CUSIP No. 638882100                 13G                    Page 5 of 12 Pages

____________________________________________________________________________
     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. 
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Lone Pine Associates LLC
_____________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                                  (a)  [X] 
                                                                  (b)  [ ] 
_____________________________________________________________________________
     (3)    SEC USE ONLY 
_____________________________________________________________________________
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
_____________________________________________________________________________
NUMBER OF      (5)  SOLE VOTING POWER 
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                 66,846
OWNED BY       ___________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER 
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER 
                                                 66,846
_____________________________________________________________________________
     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON 
                                                 66,846
_____________________________________________________________________________
     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ] 
_____________________________________________________________________________
     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)           
                                                0.6%
_____________________________________________________________________________
     (12)    TYPE OF REPORTING PERSON **
                                                 OO
_____________________________________________________________________________
                    ** SEE INSTRUCTIONS BEFORE FILLING OUT!


CUSIP No. 638882100                 13G                    Page 6 of 12 Pages

____________________________________________________________________________
     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. 
            OF ABOVE PERSONS (ENTITIES ONLY)
                                           Lone Pine Capital LLC
_____________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                                  (a)  [X] 
                                                                  (b)  [ ] 
_____________________________________________________________________________
     (3)    SEC USE ONLY 
_____________________________________________________________________________
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            Delaware
_____________________________________________________________________________
NUMBER OF      (5)  SOLE VOTING POWER 
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                 302,454
OWNED BY       ___________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER 
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER 
                                                 302,454
_____________________________________________________________________________
     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON 
                                                 302,454
_____________________________________________________________________________
     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ] 
_____________________________________________________________________________
     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)           
                                                2.8%
_____________________________________________________________________________
     (12)    TYPE OF REPORTING PERSON **
                                                 IA
_____________________________________________________________________________
                    ** SEE INSTRUCTIONS BEFORE FILLING OUT!


CUSIP No. 638882100                 13G                    Page 7 of 12 Pages

____________________________________________________________________________
     (1)    NAMES OF REPORTING PERSONS 
            I.R.S. IDENTIFICATION NO. 
            OF ABOVE PERSONS (ENTITIES ONLY)
                                                  Stephen F. Mandel, Jr.
_____________________________________________________________________________
     (2)    CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP ** 
                                                                  (a)  [X] 
                                                                  (b)  [ ] 
_____________________________________________________________________________
     (3)    SEC USE ONLY 
_____________________________________________________________________________
     (4)    CITIZENSHIP OR PLACE OF ORGANIZATION
                            United States
_____________________________________________________________________________
NUMBER OF      (5)  SOLE VOTING POWER 
                                                -0-
SHARES         ______________________________________________________________

BENEFICIALLY   (6)  SHARED VOTING POWER
                                                 369,300
OWNED BY       ___________________________________________________________

EACH           (7)  SOLE DISPOSITIVE POWER 
                                                -0-
REPORTING      ______________________________________________________________

PERSON WITH    (8)  SHARED DISPOSITIVE POWER 
                                                 369,300
_____________________________________________________________________________
     (9)     AGGREGATE AMOUNT BENEFICIALLY OWNED
             BY EACH REPORTING PERSON 
                                                 369,300
_____________________________________________________________________________
     (10)    CHECK BOX IF THE AGGREGATE AMOUNT 
             IN ROW (9) EXCLUDES CERTAIN SHARES **                       [ ] 
_____________________________________________________________________________
     (11)    PERCENT OF CLASS REPRESENTED 
             BY AMOUNT IN ROW (9)           
                                                3.4%
_____________________________________________________________________________
     (12)    TYPE OF REPORTING PERSON **
                                                 IN
_____________________________________________________________________________
                    ** SEE INSTRUCTIONS BEFORE FILLING OUT!


CUSIP No. 638882100                 13G                    Page 8 of 12 Pages

    This Amendment No. 1 amends and restates in its entirety the initial 
Schedule 13G (the "Schedule 13G") initially filed on June 9, 1998, as follows:

Item 1(a).     Name of Issuer:

     The name of the issuer is Natural Microsystems Corporation. (the 
"Company").  

Item 1(b).     Address of Issuer's Principal Executive Offices:

     The Company's principal executive offices are located at 100 Crossing 
Boulevard, Framingham, Massachusetts 01702.


Item 2(a).     Name of Person Filing:

     This statement is filed by:
          (i) Lone Spruce, L.P., a Delaware limited partnership ("Lone 
              Spruce"), (PN) with respect to the shares of Common Stock 
              (defined in Item 2(d) below) directly owned by it;
         (ii) Lone Balsam, L.P., a Delaware limited partnership ("Lone 
              Balsam"), (PN) with respect to the shares of Common Stock 
              directly owned by it;
        (iii) Lone Sequoia, L.P., a Delaware limited partnership ("Lone 
              Sequoia"), (PN) with respect to the shares of Common Stock 
              directly owned by it;
         (iv) Lone Pine Associates LLC, a Delaware limited liability company 
              ("Lone Pine"), (OO) with respect to the shares of Common Stock 
              directly owned by Lone Spruce, Lone Balsam and Lone Sequoia;
          (v) Lone Pine Capital LLC, a Delaware limited liability company 
              ("Lone Pine Capital"), (IA) which serves as investment manager 
              to Lone Cypress, Ltd., a Cayman Islands exempted company ("Lone 
              Cypress"), with respect to the shares of Common Stock directly 
              owned by Lone Cypress;
         (vi) Stephen F. Mandel, Jr. ("Mr. Mandel"), (IN) with respect to the 
              shares of Common Stock directly owned by each of Lone Spruce, 
              Lone Balsam, Lone Sequoia and Lone Cypress.

              The foregoing persons are hereinafter sometimes
         collectively referred to as the "Reporting Persons".  Any 
         disclosures herein with respect to persons other than the 
         Reporting Persons are made on information and belief after
         making inquiry to the appropriate party.

Item 2(b).     Address of Principal Business Office or, if None, Residence:

     The address of the business office of each of the Reporting Persons is Two 
Greenwich Plaza, Greenwich, Connecticut 06830.



CUSIP No. 638882100                 13G                    Page 9 of 12 Pages

Item 2(c).     Citizenship:

     Lone Spruce, Lone Balsam and Lone Sequoia are limited partnerships 
organized under the laws of the State of Delaware.  Lone Pine Associates LLC 
and Lone Pine Capital LLC are limited liability companies organized under the 
laws of the State of Delaware.  Mr. Mandel is a United States citizen.

Item 2(d).     Title of Class of Securities:

     Common Stock, $0.01 par value (the "Common Stock")

Item 2(e).  CUSIP Number:

     638882100                 


Item 3.  If this statement is filed pursuant to Rules 13d-1(b) or 13d-2(b) or 
(c), check whether the person filing is a:

          (a) [ ]   Broker or dealer registered under Section 15 of the
                    Act,

          (b) [ ]   Bank as defined in Section 3(a)(6) of the Act,

          (c) [ ]   Insurance Company as defined in Section 3(a)(19) of
                    the Act,

          (d) [ ]   Investment Company registered under Section 8 of the
                    Investment Company Act of 1940,

          (e) [ ]   Investment Adviser in accordance with Rule 
                    13d-1 (b)(1)(ii)(E),

          (f) [ ]   Employee Benefit Plan or Endowment Fund in accordance with
                    13d-1 (b)(1)(ii)(F),

          (g) [ ]   Parent Holding Company or control person in accordance 
                    with Rule 13d-1 (b)(1)(ii)(G),

          (h) [ ]   Savings Association as defined in Section 3(b) of the
                    Federal Deposit Insurance Act,
                   
          (i) [ ]   Church Plan that is excluded from the definition of an
                    investment company under Section 3(c)(14) of the 
                    Investment Company Act of 1940,

          (j) [ ]   Group, in accordance with Rule 13d-1(b)(1)(ii)(J).

If this statement is filed pursuant to Rule 13d-1(c), check this box: [X]




CUSIP No. 638882100                 13G                    Page 10 of 12 Pages

Item 4.   Ownership.

A. Lone Spruce, L.P.
             (a) Amount beneficially owned: 10,711
             (b) Percent of class: 0.1%  The percentages used herein and in the 
rest of Item 4 are calculated based upon the 10,960,751 shares of Common Stock 
issued and outstanding as of July 31, 1998 as reported in the Company's Form 
10-Q for the period ending June 30, 1998.
             (c)(i) Sole power to vote or direct the vote: -0-
               (ii) Shared power to vote or direct the vote: 10,711
              (iii) Sole power to dispose or direct the disposition: -0-
               (iv) Shared power to dispose or direct the disposition: 10,711

B. Lone Balsam, L.P.
             (a) Amount beneficially owned: 28,067
             (b) Percent of class: 0.3%  
             (c)(i) Sole power to vote or direct the vote: -0-
               (ii) Shared power to vote or direct the vote: 28,067
              (iii) Sole power to dispose or direct the disposition: -0-
               (iv) Shared power to dispose or direct the disposition: 28,067

C. Lone Sequoia, L.P.
             (a) Amount beneficially owned: 28,068
             (b) Percent of class: 0.3%  
             (c)(i) Sole power to vote or direct the vote: -0-
               (ii) Shared power to vote or direct the vote: 28,068
              (iii) Sole power to dispose or direct the disposition: -0-
               (iv) Shared power to dispose or direct the disposition: 28,068

D. Lone Pine Associates LLC
             (a) Amount beneficially owned: 66,846
             (b) Percent of class: 0.6%  
             (c)(i) Sole power to vote or direct the vote: -0-
               (ii) Shared power to vote or direct the vote: 66,846
              (iii) Sole power to dispose or direct the disposition: -0-
               (iv) Shared power to dispose or direct the disposition: 66,846

C. Lone Pine Capital LLC
             (a) Amount beneficially owned: 302,454
             (b) Percent of class: 2.8%  
             (c)(i) Sole power to vote or direct the vote: -0-
               (ii) Shared power to vote or direct the vote: 302,454
              (iii) Sole power to dispose or direct the disposition: -0-
               (iv) Shared power to dispose or direct the disposition: 302,454

D. Stephen F. Mandel, Jr.
             (a) Amount beneficially owned: 369,300
             (b) Percent of class: 3.4% 
             (c)(i) Sole power to vote or direct the vote: -0-
               (ii) Shared power to vote or direct the vote: 369,300
              (iii) Sole power to dispose or direct the disposition: -0-
              (iv) Shared power to dispose or direct the disposition: 369,300
CUSIP No. 638882100                 13G                    Page 11 of 12 Pages


Item 5.     Ownership of Five Percent or Less of a Class.

     If this statement is being filed to report the fact that as of the date 
hereof, the Reporting Persons have ceased to be the beneficial owner of more 
than five percent of the class of securities, check the following: [X]


Item 6.     Ownership of More than Five Percent on Behalf of Another Person.

Item 6 is hereby restated as follows:

     Not applicable.


Item 10.  Certification.

Item 10 is hereby restated as follows:

     Each of the Reporting Persons hereby makes the following certification:

          By signing below I certify that, to the best of my knowledge and 
belief, the securities referred to above were not acquired and are not held 
for the purpose of or with the effect of changing or influencing the control 
of the issuer of the securities and were not acquired and are not held in 
connection with or as a participant in any transaction having that purpose or 
effect.



CUSIP No. 638882100                 13G                    Page 12 of 12 Pages

SIGNATURES
	After reasonable inquiry and to the best of our knowledge and belief, 
the undersigned certify that the information set forth in this statement is 
true, complete and correct.

DATED:  November 20, 1998

LONE SPRUCE, L.P.
By:	Lone Pine Associates LLC,
	General Partner

By:	/s/ Stephen F. Mandel, Jr.	
	Stephen F. Mandel, Jr.
	Managing Member


LONE BALSAM, L.P.
By:	Lone Pine Associates LLC,
	General Partner

By:	/s/ Stephen F. Mandel, Jr.	
	Stephen F. Mandel, Jr.
	Managing Member


LONE SEQUOIA, L.P.
By:	Lone Pine Associates LLC,
	General Partner

By:	/s/ Stephen F. Mandel, Jr.	
	Stephen F. Mandel, Jr.
	Managing Member


LONE PINE ASSOCIATES LLC,

By:	/s/ Stephen F. Mandel, Jr.	
	Stephen F. Mandel, Jr.
	Managing Member


LONE PINE CAPITAL LLC,

By:	/s/ Stephen F. Mandel, Jr.	
	Stephen F. Mandel, Jr.
	Managing Member


STEPHEN F. MANDEL, JR.

/s/ Stephen F. Mandel, Jr.		









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