ANESTA CORP /DE/
10-Q, 1997-05-15
PHARMACEUTICAL PREPARATIONS
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<PAGE>   1

                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                   FORM 10-Q

    X    Quarterly report pursuant to Section 13 or 15(d) of the Securities
   ---   Exchange Act of 1934. For the quarterly period ended March 31, 1997.

         Transition report pursuant to Section 13 or 15(d) of the Securities
   ---   Exchange Act of 1934. For the transition period from        to     .
                                                              ----     ----
                             Commission File Number
                                    0-23160

                                  ANESTA CORP.
             (Exact name of registrant as specified in its charter)

            Delaware                                     87-0424798
(State or other jurisdiction of             (I.R.S. Employer Identification No.)
  incorporation or organization)

                              4745 Wiley Post Way
                               Plaza 6, Suite 650
                            Salt Lake City, UT 84116
                                 (801) 595-1405
              (Address, including zip code, and telephone number,
              including area code, of principal executive offices)

          Securities registered pursuant to Section 12(g) of the Act:

                          Common Stock $.001 par value
                                (Title of Class)

     Indicate by check mark whether the registrant (1) has filed all reports
required to be filed by Sections 13 or 15(d) of the Securities Exchange Act of
1934 during the preceding 12 months (or for such shorter period that the
registrant was required to file such reports), and (2) has been subject to such
filing requirements for the past 90 days. 

Yes X    No
   ---      ---

         Indicate the number of shares outstanding of each of the issuer's
classes of common stock, as of the latest practicable date .

         Common Stock $.001 par value                 9,481,120
                  Class                          Outstanding at May 8, 1997


<PAGE>   2
                                  ANESTA CORP.
                                     INDEX
<TABLE>
<CAPTION>
PART I.  FINANCIAL INFORMATION                                                        PAGE NO.
                                                                                      --------    
<S>                                                                                       <C>
Balance Sheets -
         March 31, 1997 (unaudited) and December 31, 1996                                 2

Statements of Operations -
         for the three months ended March 31, 1997 and
         1996 (unaudited) and the period from inception (August 1, 1985)
         to March 31, 1997 (unaudited)                                                    3

Statements of Cash Flows -
         for the three months ended March 31, 1997 and 1996 (unaudited)
         and the period from inception (August 1, 1985) to
         March 31, 1997 (unaudited)                                                       4

Notes to Financial Statements (unaudited)                                                 6

Management's Discussion and Analysis of
         Financial Condition and Results
         of Operations                                                                    9

PART II. OTHER INFORMATION                                                               11

SIGNATURES                                                                               12

</TABLE>



                                       1
<PAGE>   3
                                  ANESTA CORP.
                         (A Development Stage Company)

                                 BALANCE SHEETS

                                  -----------

<TABLE>
<CAPTION>
                                                    March 31,       December 31,
   ASSETS                                             1997             1996
                                                  ------------      ------------
                                                   (Unaudited)
<S>                                               <C>               <C>         

Current assets:
   Cash and cash equivalents                      $ 20,569,254      $ 22,807,608
   Current portion of
   certificate of deposit                              255,000           153,000
   Marketable debt securities,
    available-for-sale                              17,254,722        17,173,950
   Accounts receivable                                 112,770           485,648
   Prepaid expenses and other
      current assets                                   428,592           291,983
                                                  ------------      ------------
      Total current assets                          38,620,338        40,912,189
                                                  ------------      ------------

Property and equipment, at cost:
   Furniture and equipment                             860,267           847,521
   Leasehold improvements                            1,476,743         1,476,743
   Accumulated depreciation                           (676,419)         (617,058)
                                                  ------------      ------------
                                                     1,660,591         1,707,206
                                                  ------------      ------------

Other assets:
   Certificate of deposit                            1,938,000         1,224,000
   Other assets                                        144,157           115,474
                                                  ------------      ------------
                                                     2,082,157         1,339,474
                                                  ------------      ------------

      Total assets                                $ 42,363,086      $ 43,958,869
                                                  ------------      ------------
</TABLE>

<TABLE>
<CAPTION>
                                                              March 31,        December 31,
   LIABILITIES AND STOCKHOLDERS' EQUITY                          1997              1996
                                                             ------------      ------------
                                                              (Unaudited)
<S>                                                          <C>               <C>         
Current
liabilities:
   Accounts payable                                          $  1,031,612      $    518,965

   Accrued
   liabilities
     Accrued compensation                                         275,319           332,020
     Accrued research and development costs                       200,000           200,000
     Other                                                         69,835            92,503
   Current portion of notes payable                               250,000           150,000
                                                             ------------      ------------
       Total current liabilities                                1,826,766         1,293,488

Unearned advance royalty
revenues                                                          350,000           350,000
Notes payable                                                   1,900,000         1,200,000
                                                             ------------      ------------
       Total liabilities                                        4,076,766         2,843,488
                                                             ------------      ------------

Stockholders' equity:
   Common stock, par value, $.001 per share; Authorized:
     15,000,000 shares; Issued: 9,478,942
     in 1997 and 9,440,129 in 1996                                  9,479             9,440
   Additional paid-in capital                                  61,573,210        61,531,623
   Deficit accumulated during the
      development stage                                       (23,253,093)      (20,413,153)
   Treasury stock (345 shares), at cost                            (4,226)           (4,226)
   Notes receivable from issuance of common stock                  (7,000)           (7,000)
   Unrealized loss on marketable debt securities,
     available-for-sale                                           (32,050)           (1,303)
                                                             ------------      ------------
       Total stockholders' equity                              38,286,320        41,115,381
                                                             ------------      ------------
       Total liabilities and stockholders' equity            $ 42,363,086      $ 43,958,869
                                                             ============      ============
</TABLE>


                    The accompanying notes are an integral
                      part of the financial statements.


                                       2
<PAGE>   4


                                  ANESTA CORP.
                         (A Development Stage Company)

                            STATEMENTS OF OPERATIONS
                                  (Unaudited)

                                    --------
<TABLE>
<CAPTION>
                                                         Three months ended                      
                                                    ----------------------------       Period from   
                                                                                        inception   
                                                      March 31,        March 31,    (August 1, 1985)           
                                                        1997             1996        March 31, 1997    
                                                    -----------      -----------      ------------   
<S>                                                 <C>              <C>              <C>            
Revenues:                                                                                            
   Product sales                                    $    24,231      $    19,583      $    214,662   
   Royalty revenue                                          717              572           106,308   
   Revenues from contract research                                       375,000         9,978,931   
                                                    -----------      -----------      ------------   
                                                                                                     
     Total revenues                                      24,948          395,155        10,299,901   
                                                    -----------      -----------      ------------   
                                                                                                     
Operating costs and expenses:                                                                        
   Cost of goods sold                                     7,023            6,054            74,712   
   Royalties                                                748              605             8,248   
   Research and development                           1,816,452        1,794,575        24,662,214   
   Depreciation and amortization                         59,559           59,988           887,115   
   Marketing, general and administrative              1,533,005          611,477        10,890,576   
                                                    -----------      -----------      ------------   
                                                                                                     
     Total costs and expenses                         3,416,787        2,472,699        36,522,865   
                                                    -----------      -----------      ------------   
                                                                                                     
     Loss from operations                            (3,391,839)      (2,077,544)      (26,222,964)  
                                                                                                     
Non operating income (expense):                                                                      
   Interest income                                      602,263          308,054         4,946,620   
   Interest expense                                     (19,266)         (26,013)         (372,250)  
   Other                                                (30,288)               6           (69,649)  
                                                    -----------      -----------      ------------   
                                                                                                     
     Loss before provision for income                                                                
      taxes, extraordinary item and cumulative                                                       
      effect of accounting change                    (2,839,130)      (1,795,497)      (21,718,243)  
                                                                                                     
Provision for income taxes                                 (810)            (100)          (24,215)  
                                                    -----------      -----------      ------------   
                                                                                                     
     Loss before extraordinary item and                                                              
      cumulative effect of change in accounting      (2,839,940)      (1,795,597)      (21,742,458)  
                                                                                                     
Extraordinary item - reduction of income                                                             
   taxes arising from carryforward of prior                                                          
   years' operating losses                                                                  22,296                     
                                                                                                     

Cumulative effect of change in accounting                                               (1,041,047)                    
                                                    -----------      -----------      ------------   
                                                                                                     
     Net loss                                       $(2,839,940)     $(1,795,597)     $(22,761,209)  
                                                    -----------      -----------      ------------   
                                                                                                     
Loss per common share amounts -- 
  Loss before extraordinary item and cumulative
    effect of change in accounting                  $      (0.30)   $      (0.25)    

Net loss per common share                           $      (0.30)   $      (0.25)    
                                                    ------------    ------------
                                                                                                     
Shares used in computing net                                                                         
   loss per common share                              9,462,242        7,220,909                     
                                                    ------------    ------------
</TABLE>

                    The accompanying notes are an integral
                      part of the financial statements.



                                       3
<PAGE>   5




                                  ANESTA CORP.
                         (A Development Stage Company)

                            STATEMENTS OF CASH FLOWS
                                  (Unaudited)

                                    --------

<TABLE>
<CAPTION>
                                                                       Three months ended            Period from        
                                                                  ----------------------------        inception         
                                                                    March 31,        March 31,    (August 1, 1985)      
                                                                      1997             1996        March 31, 1997       
                                                                  -----------      -----------      ------------        
<S>                                                               <C>              <C>              <C>                 
Cash flows from operating activities:
   Net loss                                                     $ (2,839,940)     $(1,795,597)     $(22,761,209)     
   Adjustments to reconcile net loss to                                                                              
     net cash used in operating activities                                                                           
      Cumulative effect of accounting change                                                          1,041,047 
      Depreciation and amortization                                   59,559           59,988           887,115      
      Debt conversion expense                                                                           101,330    
      Interest converted to equity                                                                       94,104    
      Compensatory stock options and stock                                                                3,539    
      (Gain) on retirement of assets                                  30,288                             92,666   
      Increase (decrease) due to changes in:                                                                         
      Accounts receivable                                            372,878          (14,101)         (112,770)     
      Prepaid expenses and other current assets                     (136,609)        (139,169)         (428,592)     
      Other assets                                                   (28,683)           1,229          (146,734)     
      Accounts payable                                               512,647           44,514         1,031,612      
      Accrued liabilities                                            (79,369)        (175,232)          545,154      
      Unearned advance royalty revenues                                                                350,000    
                                                                ------------      -----------      ------------      
        Net cash used in operating activities                     (2,109,229)      (2,018,368)      (19,302,738)     
                                                                ------------      -----------      ------------      
                                                                                                                     
Cash flows from investing activities:                                                                                
   Capital expenditures                                              (12,944)         (19,784)       (2,333,532)     
   Proceeds from sale of assets                                           25                             10,250      
   Costs associated with license agreements                                                          (1,109,533)   
   Advances to employees                                                                                 (1,650)   
   Purchase of marketable debt                                                                                       
    securities, available-for-sale                                (2,150,372)      (2,053,485)      (41,777,907)     
   Proceeds from sale of marketable debt                                                                             
    securities, available-for-sale                                 2,008,540        2,497,501        24,442,418      
   Purchase of treasury bills                                                                        (1,174,419)   
   Proceeds from maturity of treasury bills                                                           1,174,419    
   Purchase of certificate of deposit                               (816,000)                        (2,346,000)   
   Proceeds from maturity of certificate of deposit                                                     153,000    
                                                                ------------      -----------      ------------      
        Net cash provided by (used in) investing activities         (970,751)         424,232       (22,962,954)     
                                                                ------------      -----------      ------------      
                                                                                                                     
Cash flows from financing activities:                                                                                
   Principal payments on notes payable                                                                 (187,500)   
   Proceeds from issuance of notes payable                           800,000                          3,337,700               
   Principal payments on obligations under capital leases                              (6,089)         (194,488)     
   Proceeds from issuance of common stock                             41,626           41,063        59,833,999      
   Collections on notes receivable from                                                                              
      issuance of common stock                                                                           58,000      
   Proceeds from issuance of preferred stock                                                            756,222      
      Deferred offering costs                                                                          (277,103)     
   Dividends paid on preferred stock                                                                   (491,884)     
                                                                ------------      -----------      ------------      
        Net cash provided by financing activities                    841,626           34,974        62,834,946      
                                                                ------------      -----------      ------------      
                                                                                                                     
Net increase (decrease) in cash and cash equivalents              (2,238,354)      (1,559,162)       20,569,254      
Cash and cash equivalents at beginning of period                  22,807,608        3,540,147                        
                                                                ------------      -----------      ------------      
Cash and cash equivalents at end of period                      $ 20,569,254      $ 1,980,985      $ 20,569,254      
                                                                ============      ===========      ============      


</TABLE>

                               -  Continued  -

                    The accompanying notes are an integral
                      part of the financial statements.


                                      4
<PAGE>   6

                                 ANESTA CORP.
                        (A Development Stage Company)

                     STATEMENTS OF CASH FLOWS, Continued
                                 (Unaudited)

                                   --------

<TABLE>
<CAPTION>
                                                                                                                        
                                                                       Three months ended            Period from        
                                                                  ----------------------------        inception         
                                                                    March 31,        March 31,    (August 1, 1985)      
                                                                      1997             1996        March 31, 1997       
                                                                  -----------      -----------      ------------        
<S>                                                               <C>              <C>              <C>                 
SUPPLEMENTAL SCHEDULE OF NONCASH ACTIVITIES: 
The Company issued stock and stock
options for:                                                                      
   Purchase of additional license agreement                                                         $     5,400
   Notes receivable                                                                                      71,000
                                                                                    
The Company purchased leasehold improvements                                        
   using accounts payable                                                                               251,507
                                                                                    
The Company entered into various capital lease                                      
   arrangements                                                                                         204,610
                                                                                    
The Company received stock as payment of a                                          
   note receivable                                                                                        4,226
                                                                                

</TABLE>


                    The accompanying notes are an integral
                      part of the financial statements.


                                      5
<PAGE>   7



                                  ANESTA CORP.
                         (A Development Stage Company)

                         NOTES TO FINANCIAL STATEMENTS
                                  (Unaudited)

                                  -----------

1.       Significant Accounting Policies:

         In the opinion of management, the accompanying financial statements
         contain all adjustments (consisting only of normal recurring items)
         necessary to present fairly the financial position of Anesta Corp. (a
         development stage company) (the Company) as of March 31, 1997, and the
         results of its operations for the three months ended March 31, 1997
         and 1996 and for the period from inception (August 1, 1985) to March
         31, 1997, and its cash flows for the three months ended March 31, 1997
         and 1996 and for the period from inception (August 1, 1985) to March
         31, 1997. The results of operations for the periods presented are not
         necessarily indicative of the results to be expected for the full year
         period.

         Certain information and footnote disclosures normally included in
         financial statements prepared in accordance with generally accepted
         accounting principles have been condensed or omitted. It is suggested
         that these financial statements be read in conjunction with the
         Company's Annual Report on Form 10-K for the period ended December 31,
         1996.

         Net Loss Per Share

         Net loss per common share is computed using the weighted average
         number of common and common equivalent shares outstanding during each
         period. Common stock equivalents consist of convertible preferred
         stock, common stock options and warrants. Common equivalent shares are
         excluded from the computation when their effect is antidilutive. Net
         loss per common share for the period from inception to March 31, 1997
         has not been presented as such information is not considered to be
         relevant or meaningful.

2.       Cash and Cash Equivalents and Marketable Debt Securities:

         At March 31, 1997, the Company maintained a majority of its cash and
         cash equivalents and marketable debt securities in two banks in San
         Francisco, California.

3.       Income Taxes:

         The provision for income taxes for the three months ended March 31,
         1997 and 1996 is related solely to state income taxes.





                                       6
<PAGE>   8
                                  ANESTA CORP.
                         (A Development Stage Company)

                    NOTES TO FINANCIAL STATEMENTS, Continued
                                  (Unaudited)

                                  -----------

4.       Revolving/Term Promissory Note Agreements:

         On January 11, 1995, the Company entered into a revolving/term
         promissory note in the amount of $1.5 million and on May 15, 1995, the
         term of the revolving promissory note ended and the Company entered
         into a 10 year term note in the amount of $1.5 million. Additionally,
         on March 20, 1997 the Company entered into a 8 year term note for an
         additional $800,000. The agreements provide for a constant interest
         rate of "160 basis points" above the financial institution's
         certificate of deposit rate (5.25% at March 31, 1997). The first
         payment of $150,000 was made on July 15, 1996 leaving a balance of
         $2,150,000. The second payment of $150,000 will be made on July 15,
         1997 and thereafter, payments of $250,000 will be made on
         approximately July 15 of the next 8 years. Borrowings under the
         agreement are collateralized by a certificate of deposit in the amount
         of $2,193,000, which is maintained in a bank in Salt Lake City, Utah.

5.       Funding Agreements:

         Effective September 8, 1995, the Company entered into a 1996 funding
         agreement with Abbott Laboratories Hospital Products Division
         (Abbott), under which Abbott provided $1,500,000 of funding to further
         the clinical development of Actiq(TM) to treat cancer-related pain
         (the "Actiq Cancer Pain Program"). Under the agreement, the Company
         provided additional funding required for this program during the year
         ended December 31, 1996 and completed certain program milestones.





                                       7
<PAGE>   9
                                  ANESTA CORP.
                         (A Development Stage Company)

                    NOTES TO FINANCIAL STATEMENTS, Continued
                                  (Unaudited)

                                   ---------


        6.      Stockholders' Equity:

                The table below presents the activity in stockholders' equity
                from January 1, 1997 to March 31, 1997:

<TABLE>
<CAPTION>
                                                                            DEFICIT                     
                                             COMMON STOCK                 ACCUMULATED
                                  -----------------------------------     DURING THE      TREASURY STOCK      
                                                            PAID-IN       DEVELOPMENT  --------------------
                                   SHARES      AMOUNT       CAPITAL          STAGE      SHARES      AMOUNT   
                                  ---------    ------     -----------    ------------  ---------    -------  
<S>                               <C>          <C>        <C>            <C>                <C>     <C>      
Balance at January 1, 1997        9,440,129    $9,440     $61,531,623    $(20,413,153)      345     $(4,226) 
                                                                                                             
Exercise of stock options in                                                                                 
   Feb. 1997 (at $.80 per share)     28,563        28          22,822                                        
                                                                                                             
Exercise of stock options in                                                                                 
   Mar. 1997 (at $.80 per share)        500         1             399                                        
                                                                                                             
Exercise of stock options in                                                                                 
   Mar. 1997 (at $1.00 per share)     8,250         8           8,242                                        
                                                                                                             
Exercise of stock options in                                                                                 
   Mar. 1997 (at $6.75 per share)     1,500         2          10,124                                        
                                                                                                             
Net change in unrealized loss on                                                                             
   marketable debt securities,                                                                               
   available-for-sale                                                                                        
                                                                                                             
Net loss                                                                   (2,839,940)                       
                                  ---------    ------     -----------    ------------  ---------    -------  
                                                                                                             
Balance at March 31, 1997         9,478,942    $9,479     $61,573,210    $(23,253,093)      345     $(4,226) 
                                  ---------    ------     -----------    ------------  ---------    -------  

<CAPTION>
                                                          UNREALIZED                                   
                                         NOTES              LOSS ON                                    
                                       RECEIVABLE       MARKETABLE DEBT                               
                                     FROM ISSUANCE        SECURITIES,                                 
                                       OF COMMON         AVAILABLE-FOR-                               
                                         STOCK               SALE            TOTAL                      
                                     ------------       ---------------   -----------                 
                                                                                                      
<S>                                     <C>                 <C>           <C>                           
Balance at January 1, 1997              $(7,000)            $(1,303)      $41,115,381                   
                                                                                                      
Exercise of stock options in                                                                          
   Feb. 1997 (at $.80 per share)                                               22,850                    
                                                                                                      
Exercise of stock options in                                                                          
   Mar. 1997 (at $.80 per share)                                                  400                    
                                                                                                      
Exercise of stock options in                                                                          
   Mar. 1997 (at $1.00 per share)                                               8,250                    
                                                                                                      
Exercise of stock options in                                                                          
   Mar. 1997 (at $6.75 per share)                                              10,126                    
                                                                                                      
Net change in unrealized loss on                                                                      
   marketable debt securities,                                                                        
   available-for-sale                                       (30,747)          (30,747)          
                                                                                                      
Net loss                                                                   (2,839,940)                 
                                   ------------         -----------       -----------                     
                                                                                                      
Balance at March 31, 1997               $(7,000)           $(32,050)      $38,286,320                   
                                   ------------         -----------       -----------                     
</TABLE>





                                       8
<PAGE>   10
ITEM 2.  MANAGEMENT'S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION 
         AND RESULTS OF OPERATIONS

The following Management's Discussion and Analysis of Financial Condition and
Results of Operations contains forward-looking statements which involve risks
and uncertainties. The Company's actual results could differ materially from
those anticipated in these forward-looking statements as a result of certain
factors discussed in this section.

RESULTS OF OPERATIONS

Revenues.

Total revenues decreased by $370,200 or 93.7% for the three months ended March
31, 1997 as compared to the corresponding period in 1996. The decrease is
primarily a result of the completion of funding by Abbott in 1996 under a
collaborative agreement. Substantially all revenues in the period ended March
31, 1996 were from development funding under collaborative agreement with
Abbott relating to the Actiq cancer pain program.

Under the Company's agreements with Abbott, Abbott manufactures Anesta's
OT-fentanyl product line (Fentanyl Oralet(R) and Actiq) and sells these
products to the Company at a price which reflects Abbott's cost of
manufacturing. The Company then sells the products to Abbott at a price related
to Abbott's selling price which results in a gross profit to the Company
ranging from approximately 40-70%. In addition, the Company is entitled to
receive a royalty on OT-fentanyl product sales by Abbott.

Operating Expenses.

Research and development expenses increased by $21,900 or 1.2% for the three
months ended March 31, 1997 as compared to the corresponding period in 1996.
The increase in research and development expenses is due to higher expenditures
for new product development and other expenditures for product development,
including clinical trials. The Company expects that its research and
development expenses will grow significantly during the remainder of 1997 as a
result of increased expenses related to the hiring of additional personnel,
preclinical studies, clinical trials, product development and manufacturing
process development activities.

Depreciation expense decreased by $400 or 0.7% for the three months ended March
31, 1997 as compared to the corresponding period in 1996.

Marketing, general and administrative expenses increased by $921,500 or 151%
for the three months ended March 31, 1997 as compared to the corresponding
period in 1996. The increase in marketing, general and administrative expenses
is due primarily to higher expenditures for personnel, corporate development
activities, marketing research, Actiq pre-marketing activities, and equipment
leasing. The Company expects that its marketing, general and administrative
expenses will increase significantly during 1997 as a result of the increased
support required for marketing research, Actiq pre-launch market development
activities, patent and corporate development activities.

Non Operating Income (Expense).

Interest income increased by $263,900 for the three months ended March 31, 1997
as compared to the corresponding period in 1996. The increase is primarily due
to invested net proceeds of $27,858,225 from the Company's secondary offering
completed in June 1996.

Interest expense decreased by $6,700 for the three months ended March 31, 1997
as compared to the corresponding period in 1996. The decrease is primarily due
to a lower balance of capital lease obligations.




                                      9
<PAGE>   11
Accounting Change.

Effective January 1, 1995, the Company changed its method of accounting for
external legal costs related to patents. Prior to the change, the Company
capitalized these costs and amortized them over the term of the related patent.
Under the new method, these costs are expensed as incurred.

Net Loss.

As a result of the increase in research and development, marketing, general and
administrative activities and other factors discussed above, the net loss for
the three months ended March 31, 1997 was $2,839,900 or $0.30 per share as
compared to $1,795,600 or $0.25 per share for the same period in 1996.

LIQUIDITY AND CAPITAL RESOURCES

In June 1996 the Company realized net proceeds of $27,858,225 through the
issuance of common stock in a secondary offering. As of March 31, 1997, the
Company had cash and cash equivalents totaling $20,569,300, $2,193,000 in a
certificate of deposit used as collateral for a revolving/term loan (See Note 4
to Financial Statements) and $17,254,700 in marketable debt securities which
are available for sale. Thus cash, cash equivalents, certificate of deposit and
marketable debt securities totaled $40,016,976 as of March 31, 1997. Cash in
excess of immediate requirements is invested according to the Company's
investment policy, which provides guidelines with regard to liquidity and
return, and, wherever possible, seeks to minimize the potential effects of
concentration of credit risk.

The Company used cash in operating activities of $2,139,500 for the three
months ended March 31, 1997 compared to $2,018,400 for the corresponding period
in 1996. The increase in cash used in the period is a direct result of the
increase in research and development and marketing, general and administrative
activities discussed above.

During the three months ended March 31, 1997, the Company made capital
expenditures of approximately $12,900, as compared to capital expenditures of
$19,800 during the corresponding period in 1996.

During the three months ended March 31, 1997, the Company realized cash
proceeds of $41,600 relating to the exercise of stock options as compared to
$41,100 during the corresponding period in 1996.

During the three months ended March 31, 1997, the Company made no principal
payments on capital lease obligations as compared to $6,100 for the
corresponding period in 1996.

The Company expects to continue to incur substantial expenses related to the
continuation and expansion of research and development, including clinical
trials, and increased marketing, general and administrative activities over at
least the next several years. The Company anticipates that the existing cash,
cash equivalents and marketable debt securities, and interest earned thereon
provides adequate working capital through 1999.

The Company's working capital requirements may change depending on numerous
factors, including the following; the progress of the Company's research and
development programs, the results of clinical studies, the number and nature of
individual products and new indications the Company pursues in clinical
studies, the timing of regulatory approvals, technological advances,
determinations as to the commercial potential of the Company's products, the
status of competitive products, the establishment of collaborative
relationships with other companies and other factors.




                                      10

<PAGE>   12
Part II. Other Information

Item 6.  Exhibits and Reports on Form 8-K.

         a)       Exhibits.

                  (10.22) Modification Agreement by and between First Security
                          Bank, NA and the Company dated as of March 20, 1997.

                  (27)    Financial Data Schedule

         b)       Reports on Form 8-K.

                  None.


                                      11

<PAGE>   13
                                  SIGNATURES

         Pursuant to the requirements of the Securities Exchange Act of 1934,
the registrant has duly caused this report to be signed on its behalf by the
undersigned thereunto duly authorized.

Date:   March 12, 1997                                          ANESTA CORP.
                                    
                                    
                                    
                                    By:      /s/  William C. Moeller
                                       -----------------------------------
                                        William C. Moeller, Chief
                                         Executive Officer and
                                         Treasurer
                                        (Authorized Signatory and
                                        Principal Financial Officer)
                                    
                                    
                                    
                                    By:      /s/   Roger P. Evans
                                       -----------------------------------
                                        Roger P. Evans, Controller
                                        (Principal Accounting Officer)
                                                
                                                



                                      12

<PAGE>   14

                              INDEX TO EXHIBITS



<TABLE>
<CAPTION>
EXHIBIT
  NO.                    DESCRIPTION
- -------                  -----------
<S>           <C>
 (10.22)      -  Modification Agreement by and between First Security Bank, NA
                 and the Company dated as of March 20, 1997.

 (27)         -  Financial Data Schedule

</TABLE>




<PAGE>   1

                                                                 EXHIBIT 10.22



FIRST                                       ASSIGNMENT OF TIME CERTIFICATE OF
SECURITY                                    DEPOSITS, OTHER INSTRUMENT, OR
BANK                                        DEPOSIT ACCOUNT
                                                                   
                                                         LOAN NO.: 0000187-9001
                                                                   ------------
                                                              March 20, 1997
                                                              --------------
                                                              DATE

FOR VALUE RECEIVED, Anesta Corp.
                    ------------------------------------------------------------

- --------------------------------------------------------------------------------
                                   OWNER(S)

DO(ES) HEREBY SELL, ASSIGN, AND TRANSFER THE FOLLOWING AT: 

First Security Bank, N.A.
- ----------------------------------
NAME OF DEPOSIT INSTITUTION
 

TIME DEPOSIT ACCOUNT NUMBER:                        MATURITY DATE:
                            ---------------------                  -------------

SAVINGS ACCOUNT NUMBER:
                       ---------------------------------------------------------

CERTIFICATE OR OTHER INSTRUMENT NUMBER: 051-999-2660390   DATED: 03/19/97
                                        ---------------          --------

                                                     MATURITY DATE: 07/15/97
                                                                    --------
AMOUNT SIGNED: $816,000.00

     TOGETHER WITH ALL RENEWALS, ROLLOVERS, REPLACEMENTS, AND EXCHANGES THEREOF
TO FIRST SECURITY BANK N.A. ("ASSIGNEE") FOR THE FOLLOWING PURPOSE: to secure a
loan evidenced by a Promissory Note dated January 11, 1995, executed by Anesta
Corp. , AND HEREBY IRREVOCABLY CONSTITUTE AND APPOINT FIRST SECURITY BANK, N.A.
ATTORNEY TO TRANSFER TO ASSIGNEE'S EXCLUSIVE CONTROL SAID CERTIFICATE, OTHER
INSTRUMENT, OR DEPOSIT ACCOUNT ON THE RECORDS OF THE ISSUING BANK OR OTHER
ISSUING AUTHORITY.

Anesta Corp.

      /s/  Thomas B. King
- -------------------------------------
Thomas B. King, President


      /s/  Roger P. Evans
- -------------------------------------
Roger P. Evans, Controller


<PAGE>   2
                      ATTACHMENT TO MODIFICATION AGREEMENT
                              DATED March 3, 1997

                        MODIFICATIONS TO LOAN DOCUMENTS

The Loan Documents shall be amended as follows:

In addition to the terms and conditions of the loan, Borrower agrees to the
following:

            If First Security has not received the full amount of any payment by
         the end of fifteen (15) calendar days after the date due, including the
         balance due at maturity, Borrower will pay a late charge to First
         Security in the amount of five percent (5%) of the overdue payment
         of principal and interest or $1,000.00, whichever is less. Borrower
         hereby agrees to pay the late charge promptly, but only once on each
         late payment.

            In addition to any late charges that may be assessed as herein
         provided, the outstanding balance of this Note after a default in
         payment of principal and/or interest or any part thereof, including but
         not limited to a default in making the final payment due at maturity,
         or a default as defined in any Loan agreement, any document securing
         this Note, or any other document executed in connection with this Note,
         shall accrue interest from the date of the default at the rate equal to
         four (4) percentage points per annum in excess of the interest rate
         charged if this Note were not in default. If First Security shall waive
         in writing or permit a cure of such default, the interest rate shall
         revert to the non-default rate from and after such waiver or completion
         of such cure.

All other terms and conditions shall remain unchanged.


<PAGE>   3
FIRST                                                MODIFICATION AGREEMENT
SECURITY
BANK                                                 LOAN NO.: 0000187-9001

     First Security Bank, N.A. ("First Security") has extended credit (the
"Loan") to the undersigned (individually and collectively "Borrower") pursuant
to a promissory note dated January 11, 1995 (the "Note") in the stated
principle amount of $1,500,000.00 . The loan is: [check one box]

     [ ]   unsecured.

     [x]   secured by security agreements, trust deeds, mortgages, lien
           instruments, and/or other collateral documents ( the "Collateral 
           Documents").

If neither of the boxes is checked, the Loan shall be deemed to be secured.

     The note and any loan agreements, guaranties, subordinations, Collateral
Documents, and other instruments and documents executed in connection
therewith, together with any previous modifications to any of these instruments
or documents, shall be referred to as the "Loan Documents."

     Borrower has requested certain modifications to the Loan Documents and
First Security is willing to grant such modifications on the following terms
and conditions:

     1. Provided that all conditions stated herein are satisfied, the terms of
the Loan Documents are hereby modified as follows: [check the applicable
box(es)]

MODIFICATIONS TO THE TERMS OF THE NOTE:

     [ ] The MATURITY DATE of the note is extended to _________________________

     [ ] The INTEREST RATE under the Note is modified effective _______________,
         to be ________________________________________________________________
         _________________________________________________ per annum. A 
         variable interest rate based upon the prime rate shall be adjusted
         with each change in the prime rate. The following definition applies to
         interest rate based on First Security's prime rate.

         First Security's "prime rate" is its announced rate of interest used as
         a reference point from which it may calculate the cost of credit to
         customers. It is subject to change from time to time. First Security
         may make loans bearing interest above, at, or below its prime rate.
        
     [x] The PRINCIPAL AMOUNT available under the Note is being changed as
         follows: [check one]

         [ ] The Note's stated principal amount is being changed to $_________,
             representing the maximum outstanding principal permitted under the
             Note (any principal amount outstanding in excess of this new 
             maximum must be paid on the Note as a condition precedent to this 
             Agreement).

<PAGE>   4


         [x]  First Security agrees to loan up to an additional $800,000.00 
              over the current principal outstanding on the Note, which is 
              $1,350,000.00 as of the date of this Agreement.

         This Agreement does not constitute a repayment or extinguishment of the
         Note, but only a modification thereof.

     [x] The REPAYMENT TERMS of the Note are modified as follows: One payment
         of principal in the amount of $150,000.00 due July 15,1997, thereafter,
         equal installments of principal in the amount of $250,000.00 each
         beginning July 15,1998 and continuing ANNUALLY thereafter until July
         15, 2005. Accrued interest on this Note shall be paid MONTHLY,
         beginning April 15, 1997 and continuing on the 15th day of each month
         thereafter. The entire balance of outstanding principal and accrued but
         unpaid interest shall be due and payable on July 15, 2005.
        
OTHER MODIFICATIONS TO THE LOAN DOCUMENTS:

     [x] The LOAN DOCUMENTS shall be amended as follows:A First Security Bank
         Certificate of Deposit Account #051-999-2660390, in the amount of
         $816,000.00, in the name of Anesta Corp., dated 3/19/97 shall be added
         as security on this Loan. A late charge and default rate as set forth
         in the attachment hereto are added to the terms of the Note. The
         Pledged Assets Schedule to Commercial Credit and Security Agreement,
         Section 1 shall be amended to read: All Certificates of Deposit of
         Borrower issued by First Security as such certificates may be
         identified by an Assignment of Time Certificate of Deposit, Other
         Instrument, or Deposit Account.
        
     2.  As preconditions to the terms of this Agreement, Borrower shall
complete or provide the following: [if none, type N/A in subsection 2.1]

     2.1 N/A

     2.2 N/A

     3.  As an additional precondition to the terms of this Agreement, Borrower
shall pay or shall have paid all reasonable fees, costs, and expenses, of
whatever kind of nature, incurred by First Security in connection with this
Agreement, including but not limited to attorney's fees, lien search fees,
title reports and policies, and recording and filing fees.

     4.  It is the intention and agreement of Borrower and First Security that:
(I) all collateral security in which First Security has acquired a security
interest or other lien pursuant to the Loan Documents shall continue to serve
as collateral security for payment and performance of all the obligations of
the Borrower under the Loan Documents, and (ii) all agreements,
representations, warranties, and covenants contained in the Loan Documents are
hereby reaffirmed in full by the Borrower except as specifically modified by
this Agreement.

     5.  Borrower hereby acknowledges that: (I) the Loan Documents are in full
force and effect, as modified by this Agreement, and (ii) by entering into this
Agreement, First Security does not waive any existing default or any default
hereafter occurring or become obligated to waive any condition or obligation
under the Loan Documents.


<PAGE>   5


     6. Borrower hereby acknowledges that Borrower has no claim, demand,
lawsuit, cause of action, claim for relief, remedy, or defense against
enforcement of the Loan Documents that could be asserted against First
Security, its affiliates, directors, officers, employees, or agents, whether
known or unknown, for acts, failures to act (whether such act or failure to act
is intentional or negligent), representations, commitments, statements and
warranties, including without limitation any such conduct arising out of or in
any way connected with the Loan Documents. Notwithstanding the foregoing,
Borrower hereby waives, releases, and relinquishes any and all claims, demands,
lawsuits, causes of action, claims for relief, remedies, or defenses against
enforcement of the Loan Documents that could be asserted against First
Security, its affiliates, directors, officers, employees, or agents, whether
known or unknown.

     7. In addition to this Agreement, the Loan Documents, and any additional
documents that this Agreement requires, this finance transaction may include
other written closing documentation such as resolutions, waivers, certificates,
financing statements, filings, statements, closing or escrow instructions, loan
purpose statements, and other documents that First Security may customarily use
in such transactions. Such documents are incorporated herein by this reference.
All the documents to which this paragraph makes reference express, embody, and
represent the final expression of the agreement between First Security and
Borrower, the terms and conditions of which cannot hereafter be contradicted by
any oral understanding ( if any ) not reduced to writing and identified above.

Effective as of   March 20, 1997

FIRST SECURITY:

First Security Bank, N.A.

      /s/ Steven M. Kohler
- -------------------------------------
Steven M. Kohler, Vice President

BORROWER:

Anesta Corp., a Delaware corporation

      /s/ Thomas B. King                             /s/ Roger P. Evans
- -------------------------------------        ----------------------------------
Thomas B. King, President                    Roger P. Evans, Controller



<PAGE>   6
FIRST                                       ACCOUNT NUMBER:0519992660390
SECURITY
BANK                                        NEGOTIABLE CERTIFICATE OF DEPOSIT

Issued at (office)  Main @ First South - 051  
                    ------------------------
City and State      Salt Lake City, UT
                    ------------------------

This is to certify that  ***Anesta Corp*** herein called Registered Owner(s) has
deposited in this Bank the sum of Eight Hundred Sixteen Thousand-----------
dollars payable at the issuing office to the Registered Owner(s) upon
presentation and surrender of this certificate properly endorsed on (maturity
date) 07-15-97.   The interest rate is 5.00 % with an annual percentage yield of
5.12%.  The annual percentage yield was calculated, using the terms you
requested, with the interest compound N/A, paid Monthly, by depositing to
Checking #060-00119-51.  This deposit is a First Security Bank Negotiable
Certificate of Deposit which is subject to the terms and conditions set forth
below.  Substantial penalty for redemption prior to maturity.


                                           /s/ Dawn Carroll
                                        ---------------------------------------
                                        (Authorized Signature)

- --------------------------------------------------------------------------------

                              ACCOUNT CONDITIONS

o    The interest rate and annual percentage yield on this account will remain
     fixed until maturity.

o    The term of this account may range from fourteen (14) days to five (5)
     years. The specific term you have chosen is disclosed on your Negotiable
     Certificate of Deposit.

o    This account will not automatically renew at maturity for an additional
     like term. If you do not renew the account, your deposit will be placed in
     a non interest earning account. No interest will be paid after final
     maturity.

o    Additional deposits to this account are not permitted.

o    To determine the annual percentage yield we assume the interest will
     remain on deposit until maturity. A withdrawal will reduce earnings.

<PAGE>   7


o    Interest begins to accrue for the deposit of non-cash items (for example,
     checks) no later than the business day credit is received under the
     applicable availability schedule established by the Federal Reserve
     pursuant to the Expedited Funds Availability Act and Regulation CC.

o    We use the daily balance method to calculate the interest on this
     account. This method applies a daily periodic rate to the principal in the
     account each day.

o    The Federal Deposit Insurance Corporation (FDIC) is a government agency
     organized to insure deposits. Your basic insured amount is $100,000.
     Deposits maintained in different categories of legal ownership are
     separately insured. It is therefore possible for you to have more than
     $100,000 insurance coverage in a single institution if the funds are owned
     and deposited in different categories. Your insurance limit is applied to
     the combined total amount you hold within each ownership category. Refer
     to the FDIC publication Your Insured Deposit for details.

o    This account is a Time Deposit subject to all applicable rules and
     regulations of the Board of Governors of the Federal Reserve System and of
     First Security Bank.

o    This account is payable only to the registered account owner(s) upon
     surrender of your Negotiable Certificate of Deposit, properly endorsed, to
     the issuing office.

o    If this account is owned by multiple original payees (i.e. joint owners)
     consisting of two or more natural persons, they shall hold the account
     with right of survivorship. The deposit (together with interest) is
     payable to any one of them during their joint lives. Each owner, acting
     alone, can withdraw or transfer funds from this account or can effectively
     terminate this account by withdrawing all or substantially all of the
     funds and depositing the same in a new account which omits the name of one
     of the owners. Upon the death of any of the owners, all of the right,
     title and interest to this account shall vest absolutely in the survivor
     or survivors, subject to all applicable tax statutes and regulations. Each
     of such persons shall be the agent of the other to give or receive any
     notice provided for herein or to take any other action pertaining to this
     account.

o    If this account is opened with the added conditions of "payable on death"
     ("POD") to one or more persons, ownership of this account shall in the POD
     payee or payees only upon the death of all of the original payees and
     shall be otherwise governed by applicable statutes.

o    If funds are withdrawn from this account before maturity, Federal Reserve
     regulations require an early withdrawal penalty, unless the withdrawal is
     due to death or incompetency of an owner. The penalty is at the interest
     rate being paid at the time of withdrawal and applies regardless of the
     length of time the funds have remained on deposit. The penalty is in terms
     of interest on the amount withdrawn and may require reduction in the
     principal sum of the account. The penalty for the early withdrawal of
     funds is as follows:

     Accounts with maturities of:

     Seven to 31 days          All interest earned to date of withdrawal, or all
                               interest that could have been earned for one- 
                               half the maturity period, whichever is greater.

<PAGE>   8


     32 days to 12 months      One month's interest earned or that could have 
                               been earned.

     More than 12 months       Three months' interest earned or that could have
                               been earned.

o    We reserve the right to change any of the terms and conditions of this
     account provided we so notify you in writing at least thirty (30) advance.

o    Interest checks, if applicable, and notices relative to this account will
     be mailed to your last known address.

o    We are required by Federal law to obtain your Taxpayer Identification
     Number (TIN) upon opening this account. A TIN can be Social Security
     Number or an Employer Identification Number. If you do not provide us with
     a TIN and certify under penalty or perjury that the TIN is correct you may
     be subject to certain penalties as well as backup withholding of any
     interest earned on this account at the rate of thirty-one (31) percent.

o    We reserve the right not to open this account if you do not provide a TIN
     certified to be correct. If you are applying for a TIN, the account will
     be opened if you so certify on form W-9. In such cases, we must apply
     backup withholding on earnings on your account until the TIN is provided.
     We reserve the right to close this account if your TIN is not provided
     within sixty (60) days after account opening.

o    You are also required at the time you open the account to certify that
     you are not subject to backup withholding. If you do not so certify the
     required to withhold tax from the earnings on your account at the rate of
     thirty-one (31) percent.



<PAGE>   9
FIRST
SECURITY                                    COLLATERAL RECEIPT
BANK

DATE:    March 20, 1997                     RECEIPT NUMBER: 107115
       ------------------                                   ------

NAME:    Anesta Corp.
     ---------------------------------------------------------------------------
ADDRESS:
        ------------------------------------------------------------------------

- --------------------------------------------------------------------------------

THE FOLLOWING DESCRIBED COLLATERAL AS SECURITY TO NOTE OF $_____________________

DATED:                                      DUE:
      -------------------------------            -------------------------------

- --------------------------------------------------------------------------------
DESCRIPTION OF COLLATERAL:

A First Security Bank certificate of deposit account #051-999-26603-90 in the
amount of $816,000.00, in the name of Anesta Corp., dated 3/19/97




- --------------------------------------------------------------------------------
FIRST SECURITY BANK, N.A.
                     ----
          
BY:        /s/ Steven M. Kohler
   ---------------------------------------
      Steven M. Kohler, Vice President


<TABLE> <S> <C>

<ARTICLE> 5
<MULTIPLIER> 1,000
       
<S>                             <C>
<PERIOD-TYPE>                   3-MOS
<FISCAL-YEAR-END>                          DEC-31-1997
<PERIOD-START>                             JAN-01-1997
<PERIOD-END>                               MAR-31-1997
<CASH>                                          20,569
<SECURITIES>                                    17,255
<RECEIVABLES>                                      113
<ALLOWANCES>                                         0
<INVENTORY>                                          0
<CURRENT-ASSETS>                                38,620
<PP&E>                                           2,337
<DEPRECIATION>                                     676
<TOTAL-ASSETS>                                  42,363
<CURRENT-LIABILITIES>                            1,827
<BONDS>                                          1,900
                                0
                                          0
<COMMON>                                             9
<OTHER-SE>                                      38,277
<TOTAL-LIABILITY-AND-EQUITY>                    42,363
<SALES>                                             24
<TOTAL-REVENUES>                                    25
<CGS>                                                8
<TOTAL-COSTS>                                    3,417
<OTHER-EXPENSES>                                     0
<LOSS-PROVISION>                                     0
<INTEREST-EXPENSE>                                  19
<INCOME-PRETAX>                                (2,840)
<INCOME-TAX>                                         0
<INCOME-CONTINUING>                            (2,840)
<DISCONTINUED>                                       0
<EXTRAORDINARY>                                      0
<CHANGES>                                            0
<NET-INCOME>                                   (2,840)
<EPS-PRIMARY>                                    (.30)
<EPS-DILUTED>                                    (.30)
        

</TABLE>


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