<PAGE>
<TABLE>
<CAPTION>
<S> <C>
------------------------------------- ---------------------------------
FORM 5 OMB APPROVAL
------------------------------------- OMB NUMBER 3235-0362
ESTIMATED AVERAGE BURDEN
/ / CHECK THIS BOX IF NO LONGER U.S. SECURITIES AND EXCHANGE COMMISSION HOURS PER RESPONSE ... 1.0
SUBJECT TO SECTION 16. FORM 5 WASHINGTON, D.C. 20549 ---------------------------------
OBLIGATIONS MAY CONTINUE. SEE ANNUAL STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP
INSTRUCTION 1(b).
/ / FORM 3 HOLDINGS REPORTED
/ / FORM 4 TRANSACTIONS REPORTED
Filed pursuant to Section 16(a) of the Securities Exchange Act
of 1934, Section 17(a) of the Public Utility Holding Company Act
of 1935 or Section 30(f) of the Investment Company Act of 1940
</TABLE>
<TABLE>
<CAPTION>
<S> <C> <C>
---------------------------------------------- --------------------------------------- --------------------------------------------
1. NAME AND ADDRESS OF 2. ISSUER NAME AND TICKER 6. RELATIONSHIP OF
REPORTING PERSON* OR TRADING SYMBOL REPORTING PERSON TO ISSUER
(Check if applicable)
_X_ Director ___ 10% Owner
__ Officer ___ Other
(give title (specify
below) below)
Sistermans Joop IGEN International,
Inc.
----------------------- ---------------------- ----------------------------- ----------------- ------------------------------------
(Last) (First) (Middle) 3. IRS OR SOCIAL SECURITY 4. STATEMENT FOR
NUMBER OF REPORTING MONTH/YEAR
PERSON (VOLUNTARY)
-----------------------------------
Origin International, BV 03/31/00 7. INDIVIDUAL OR JOINT/GROUP
Groeneweoudseweg 1 FILING (CHECK APPLICABLE LINE)
5621 BA Eindhover
VH9-room 8 X Form filed by One Reporting
---
Person
___ Form filed by More than One
Reporting Person
-------------------------------------------- ------------------
(Street) 5. IF AMENDMENT,
DATE OF
ORIGINAL
(MONTH/YEAR)
5600MD The
Eindhoven Netherlands
</TABLE>
<TABLE>
<CAPTION>
----------------------- --------------------- --------------------------------- ----------------------------------------------------
<S> <C> <C>
(City) (State) (Zip) TABLE 1 - NON-DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR BENEFICIALLY OWNED
----------------------- --------------------- --------------------------------- ----------------------------------------------------
1. Title of 2. Trans- 3. Transac- 4. Securities Acquired (A) or 5. Amount of 6. Ownership 7. Nature
Security action tion Disposed of (D) Securities Form: of In-
(Instr. 3) Date Code (Instr. 3, 4, and 5) Beneficially Direct direct
(Month/ (Instr. Owned at End (D) or Beneficial
Day/ 8) of Issuer's (I) Indirect Ownership
Year) Fisc. Y (Instr. 4) (Instr.
(Instr. 3 . 4)
and 4)
----------------------------------------
Amount (A) or (D) Price
------------------------------------------------------------------------------------------------------------------------------------
None
------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------------
</TABLE>
Reminder: Report on a separate line for each class of securities beneficially
owned directly or indirectly. (Over) * If the form is filed by more than one
reporting person, SEE Instruction 4(b)(v). (Print or Type Responses)
<PAGE>
FORM 5 (CONTINUED) TABLE II - DERIVATIVE SECURITIES ACQUIRED, DISPOSED OF, OR
BENEFICIALLY OWNED (E.G., PUTS, CALLS, WARRANTS, OPTIONS,
CONVERTIBLE SECURITIES)
<TABLE>
<CAPTION>
----------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C> <C>
1. Title of Derivative Security 2. Conversion 3. Trans- 4. Trans- 5. Number of 6. Date Exercisable
(Instr. 3) or Exercise action action Derivative and Expiration Date
Price of Date Code Securities (Month/Day/Year)
Derivative (Month/ (Instr.8) Acquired (A)
Security Day/ or Disposed
Year) of (D) (Instr. 3,
4, and 5)
-----------------------
Date Expiration
Exercis- Date
able
-------------------
(A) (D)
----------------------------------------------------------------------------------------------------------------
Option (Right to Buy) $ 24.69 9/16/99 A 10,000 (1) 9/15/09
----------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------
----------------------------------------------------------------------------------------------------------------
</TABLE>
<TABLE>
<CAPTION>
------------------------------------------------------------------------------------------------------------------------------
<S> <C> <C> <C> <C>
1. Title of Derivative Security 7. Title and Amount of 8. Price of 9. Number 10. Ownership 11. Nature
(Instr. 3) Underlying Securities Derivative of Derivative of of
(Instr. 3 and 4) Security Securities Derivative Indirect
(Instr.5) Beneficially Security: Benefi-
Owned Direct (D) cial
at End or Indirect Owner-
of Year (1)(Instr.4) ship
(Instr. 4) (Instr.4)
---------------------
Title Amount or
Number of
Shares
------------------------------------------------------------------------------------------------------------------------------
Option (Right to Buy) Common 10,000 0 D
Stock
------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------
------------------------------------------------------------------------------------------------------------------------------
</TABLE>
Explanation of Responses:
(1) Options granted under the Issuer's 1994 Non Employee Directors' Stock
Option Plan. Twenty percent of the options vest one year from the grant
date and then an additional 5 percent vest each quarter thereafter.
** Intentional misstatements or omissions of facts constitute Federal Criminal
Violations.
SEE 18 U.S.C. 1001 and 15 U.S.C. 78ff(a)
/s/ Joop Sistermans July 25, 2000
---------------------------------------------
**Signature of Reporting Person Date
Joop Sistermans
Note: File three copies of this Form, one of which must be manually signed. If
space provided is insufficient, SEE Instruction 6 for procedure.
Potential persons who are to respond to the collection of information contained
in this form are not required to respond unless the form displays a currently
valid OMB Number.
2
