INTEGRA LIFESCIENCES CORP
SC 13D, 1999-04-08
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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                       SECURITIES AND EXCHANGE COMMISSION
                             Washington, D.C. 20549

                                  SCHEDULE 13D
                                 (Rule 13d-101)

             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
            TO RULE 13d-1(a) AND AMENDMENTS THERETO FILED PURSUANT TO
                                  RULE 13d-2(a)

                                (Amendment No. )*

                        INTEGRA LIFESCIENCES CORPORATION
             _______________________________________________________
                                (Name of Issuer)

                     Common Stock, Par Value $0.01 Per Share
                      _____________________________________
                         (Title of Class of Securities)
                                    457985208
                                   __________
                                 (CUSIP Number)

                              Stephen M. Vine, Esq.
                    Akin, Gump, Strauss, Hauer & Feld, L.L.P.
                               590 Madison Avenue
                            New York, New York 10022
                                 (212) 872-1000
             _______________________________________________________
                  (Name, Address and Telephone Number of Person
                Authorized to Receive Notices and Communications)

                                 March 29, 1999
                             _______________________
                      (Date of Event which Requires Filing
                               of this Statement)

If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  that is the subject of this  Schedule  13D, and is filing this
schedule because of Rule 13d-1(e), 13d-1(f) or 13d-1(g), check the following box
|_|.

Note.  Schedules  filed in paper format shall include a signed original and five
copies of the  schedule,  including  all  exhibits.  See Rule 13d-7(b) for other
parties to whom copies are to be sent.

*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for  any  subsequent   amendment   containing   information  which  would  alter
disclosures provided in a prior cover page.

The information required on the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 or  otherwise  subject to the  liabilities  of that  section of the Act but
shall be subject to all other provisions of the Act (however, see the Notes).

                         Continued on following page(s)
                               Page 1 of 83 Pages
                             Exhibit Index: Page 18


<PAGE>


                                                              Page 2 of 83 Pages

                                  SCHEDULE 13D

CUSIP No. 457985208

1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Person

                  QUANTUM INDUSTRIAL PARTNERS LDC

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]     
                                                     b.  [X]

3        SEC Use Only

4        Source of Funds*

                  WC

5        Check Box If Disclosure of Legal  Proceedings  Is Required  Pursuant to
         Items 2(d) or 2(e) [ ]

6        Citizenship or Place of Organization

                  Cayman Islands

                           7        Sole Voting Power
  Number of                             2,143,350
   Shares
Beneficially               8        Shared Voting Power
  Owned By                              0
    Each
  Reporting                9        Sole Dispositive Power
   Person                               2,143,350
    With
                           10       Shared Dispositive Power
                                        0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                        2,143,350

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain
         Shares*                                          [x]

13       Percent of Class Represented By Amount in Row (11)

                                    11.99%

14       Type of Reporting Person*

                  OO; IV

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                                              Page 3 of 83 Pages

                                  SCHEDULE 13D

CUSIP No. 457985208

1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Person

                  QIH MANAGEMENT INVESTOR, L.P.

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [X]

3        SEC Use Only

4        Source of Funds*

                  AF

5        Check Box If Disclosure of Legal  Proceedings  Is Required  Pursuant to
         Items 2(d) or 2(e) [ ]

6        Citizenship or Place of Organization

                  Delaware

                           7        Sole Voting Power
  Number of                             2,143,350
   Shares
Beneficially               8        Shared Voting Power
  Owned By                              0
   Each
  Reporting                9        Sole Dispositive Power
   Person                               2,143,350
    With
                           10       Shared Dispositive Power
                                        0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                        2,143,350

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain
         Shares*                                       [x]

13       Percent of Class Represented By Amount in Row (11)

                                    11.99%

14       Type of Reporting Person*

                  PN; IA

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                                              Page 4 of 83 Pages

                                  SCHEDULE 13D

CUSIP No. 457985208

1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Person

                  QIH MANAGEMENT, INC.

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [X]

3        SEC Use Only

4        Source of Funds*

                  AF

5        Check Box If Disclosure of Legal  Proceedings  Is Required  Pursuant to
         Items 2(d) or 2(e) [ ]

6        Citizenship or Place of Organization

                  Delaware

                           7        Sole Voting Power
  Number of                             2,143,350
   Shares
Beneficially               8        Shared Voting Power
  Owned By                              0
   Each   
  Reporting                9        Sole Dispositive Power
   Person                               2,143,350
    With
                           10       Shared Dispositive Power
                                        0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                        2,143,350

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain
         Shares*                                     [x]

13       Percent of Class Represented By Amount in Row (11)

                                    11.99%

14       Type of Reporting Person*

                  CO

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                                              Page 5 of 83 Pages

                                  SCHEDULE 13D

CUSIP No. 457985208

1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Person

                  SOROS FUND MANAGEMENT LLC

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [X]

3        SEC Use Only

4        Source of Funds*

                  AF

5        Check Box If Disclosure of Legal  Proceedings  Is Required  Pursuant to
         Items 2(d) or 2(e) [ ]

6        Citizenship or Place of Organization

                  Delaware

                           7        Sole Voting Power
  Number of                             2,143,350
   Shares
Beneficially               8        Shared Voting Power
  Owned By                              0
    Each
  Reporting                9        Sole Dispositive Power
   Person                               2,143,350
    With
                           10       Shared Dispositive Power
                                        0

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                        2,143,350

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain
         Shares*                                          [x]

13       Percent of Class Represented By Amount in Row (11)

                                    11.99%

14       Type of Reporting Person*

                  OO; IA

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                                              Page 6 of 83 Pages

                                  SCHEDULE 13D

CUSIP No. 457985208

1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Person

                  GEORGE SOROS (in the capacity described herein)

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [X]

3        SEC Use Only

4        Source of Funds*

                  AF

5        Check Box If Disclosure of Legal  Proceedings  Is Required  Pursuant to
         Items 2(d) or 2(e) [ ]

6        Citizenship or Place of Organization

                  United States

                           7        Sole Voting Power
  Number of                             714,450
   Shares
Beneficially               8        Shared Voting Power
  Owned By                              2,143,350
    Each
  Reporting                9        Sole Dispositive Power
   Person                               714,450
    With
                           10       Shared Dispositive Power
                                        2,143,350

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                        2,857,800

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain
         Shares*                                           [ ]  

13       Percent of Class Represented By Amount in Row (11)

                                    15.37%

14       Type of Reporting Person*

                  IA

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                                              Page 7 of 83 Pages

                                  SCHEDULE 13D

CUSIP No. 457985208

1        Name of Reporting Person
         S.S. or I.R.S. Identification No. of Above Person

                  STANLEY F. DRUCKENMILLER (in the capacity described herein)

2        Check the Appropriate Box If a Member of a Group*
                                                     a.  [ ]
                                                     b.  [X]

3        SEC Use Only

4        Source of Funds*

                  AF

5        Check Box If Disclosure of Legal  Proceedings  Is Required  Pursuant to
         Items 2(d) or 2(e) [ ]

6        Citizenship or Place of Organization

                  United States

                           7        Sole Voting Power
  Number of                             0
   Shares
Beneficially               8        Shared Voting Power
  Owned By                              2,143,350
    Each
  Reporting                9        Sole Dispositive Power
   Person                               0
    With
                           10       Shared Dispositive Power
                                        2,143,350

11       Aggregate Amount Beneficially Owned by Each Reporting Person

                                        2,143,350

12       Check Box If the Aggregate Amount in Row (11) Excludes Certain
         Shares*                                       [x]

13       Percent of Class Represented By Amount in Row (11)

                                    11.99%

14       Type of Reporting Person*

                  IA

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>


                                                              Page 8 of 83 Pages

                  This  Statement  on  Schedule  13D relates to shares of Common
Stock,  $0.01 par  value  per share  (the  "Shares"),  of  Integra  LifeSciences
Corporation  (the  "Issuer").  This  Statement  is being filed by the  Reporting
Persons (as defined  herein) to report the recent  acquisition  of securities of
the Issuer,  convertible into Shares, as a result of which the Reporting Persons
may be deemed  to be the  beneficial  owners of more than 5% of the  outstanding
Shares of the Issuer.


Item 1.  Security and Issuer.

         This  Statement  relates to the Shares.  The  address of the  principal
executive office of the Issuer is 105 Morgan Lane, Plainsboro, New Jersey 08536.

Item 2.  Identity and Background.

         This  Statement  is being  filed  on  behalf  of each of the  following
persons (collectively, the "Reporting Persons"):

         i)       Quantum Industrial Partners LDC ("QIP");

         ii)      QIH Management Investor, L.P. ("QIHMI");

         iii)     QIH Management, Inc. ("QIH Management");

         iv)      Soros Fund Management LLC ("SFM LLC");

         v)       Mr. George Soros ("Mr. Soros"); and

         vi)      Mr. Stanley F. Druckenmiller ("Mr. Druckenmiller").

         This  Statement  relates to the Shares held for the accounts of QIP and
SFM Domestic Investments LLC ("SFM Domestic Investments").

                              The Reporting Persons

QIP, QIHMI and QIH Management
- -----------------------------

                  QIP is a Cayman Islands exempted limited duration company with
its principal  address at Kaya  Flamboyan 9,  Willemstad,  Curacao,  Netherlands
Antilles.  The principal  business of QIP is investment in  securities.  Current
information concerning the identity and background of the directors and officers
of QIP is set forth in Annex A hereto,  which is  incorporated  by  reference in
response to this Item 2.

                  QIHMI,  an investment  advisory  firm  organized as a Delaware
limited partnership,  is a minority shareholder of, and (pursuant to constituent
documents  of QIP) is vested  with  investment  discretion  with  respect to the
portfolio  assets held for the account of, QIP. The principal  business of QIHMI
is to provide  management  and advisory  services to, and to invest in, QIP. QIH
Management,  a Delaware  corporation of which Mr. Soros is the sole shareholder,
is the sole general partner of QIHMI.  The principal  business of QIH Management
is to serve as the sole general partner of QIHMI.  QIHMI and QIH Management have
their principal  offices at 888 Seventh Avenue,  33rd Floor,  New York, New York
10106.  QIHMI, by reason of its investment  discretion over the securities owned
by QIP, and QIH Management,  as the sole general  partner of QIHMI,  may each be
deemed  the  beneficial  owner of the  Shares  held for the  account  of QIP for
purposes of Section  13(d) of the  Securities  Exchange Act of 1934,  as amended
(the "Act").


<PAGE>


                                                              Page 9 of 83 Pages


                  Mr. Soros has entered into an agreement dated as of January 1,
1997 with SFM LLC pursuant to which Mr. Soros has, among other things, agreed to
use his best efforts to cause QIH  Management,  as the general partner of QIHMI,
to act at the direction of SFM LLC,  which  agreement to so act shall  terminate
upon the earlier of (a) the  assignment  to SFM LLC of the legal and  beneficial
ownership  interest in QIH  Management  and (b) the assignment to SFM LLC of the
general partnership interest in QIHMI (the "QIP Contract").


SFM LLC, Mr. Soros and Mr. Druckenmiller
- ----------------------------------------


                  The  business  of SFM  LLC is  managed  through  a  Management
Committee (the "Management Committee") comprised of Mr. Soros, Mr. Druckenmiller
and Mr. Gary Gladstein.  SFM LLC, a Delaware limited liability company,  has its
principal  office at 888 Seventh Avenue,  33rd Floor,  New York, New York 10106.
Its  principal  business is to serve,  pursuant to  contract,  as the  principal
investment manager to several foreign investment  companies (the "SFM Clients").
Mr.  Soros,  as  Chairman of SFM LLC,  has the ability to direct the  investment
decisions  of SFM LLC and as such may be  deemed to have  investment  discretion
over the securities held for the accounts of the SFM Clients. Mr. Druckenmiller,
as Lead  Portfolio  Manager of SFM LLC, has the ability to direct the investment
decisions  of SFM LLC and as such may be  deemed to have  investment  discretion
over the securities held for the accounts of the SFM Clients. Set forth in Annex
B hereto and  incorporated by reference in response to this Item 2 and elsewhere
in this Schedule 13D as  applicable  is a list of the Managing  Directors of SFM
LLC.

                  The  principal  occupation  of  Mr.  Soros,  a  United  States
citizen,  is his direction of the activities of SFM LLC, which is carried out in
his capacity as Chairman of SFM LLC at SFM LLC's principal office.

                  The principal occupation of Mr. Druckenmiller, a United States
citizen,  is  his  position  as  Lead  Portfolio  Manager  and a  Member  of the
Management  Committee  of SFM LLC,  which is carried out at SFM LLC's  principal
office.

                  Pursuant to regulations promulgated under Section 13(d) of the
Act, SFM LLC, pursuant to the provisions of the QIP Contract,  Mr. Soros, in his
capacity as Chairman of SFM LLC, and Mr. Druckenmiller,  in his capacity as Lead
Portfolio  Manager  of SFM LLC,  each may be  deemed a  beneficial  owner of the
Shares held for the account of QIP.

                  Mr. Soros may also be deemed a beneficial  owner of the Shares
held for the account of SFM Domestic Investments.  SFM Domestic Investments is a
Delaware  limited  liability  company with its principal  address at 888 Seventh
Avenue,  33rd Floor,  New York,  New York 10106.  The principal  business of SFM
Domestic Investments is investment in securities.

                  During the past five years, none of the Reporting Persons and,
to the best of the Reporting Persons' knowledge,  any other person identified in
response to this Item 2 has been (a) convicted in a criminal proceeding or (b) a
party to any civil  proceeding as a result of which it or he has been subject to
a judgment, decree or final order enjoining future violations of, or prohibiting
or mandating activities subject to, federal or state securities laws, or finding
any violation with respect to such laws.

Item 3.           Source and Amount of Funds or Other Consideration.

                  QIP expended  approximately  $7,500,000 of its working capital
to purchase  the  securities  reported  herein as being  acquired in the last 60
days. SFM Domestic Investments expended approximately  $2,500,000 of its working
capital to purchase the securities reported herein as being acquired in the last
60 days.



<PAGE>


                                                             Page 10 of 83 Pages

                  The  securities  held for the accounts of QIP and SFM Domestic
Investments may be held through margin accounts  maintained with brokers,  which
extend margin  credit as and when  required to open or carry  positions in their
margin  accounts,  subject  to  applicable  federal  margin  regulations,  stock
exchange rules and such firms' credit policies.  The positions which may be held
in the margin accounts, including the Shares, are pledged as collateral security
for the repayment of debit balances in the respective accounts.

Item 4.           Purpose of Transaction.

                  All of the Shares  reported herein as having been acquired for
or disposed of from the  accounts of QIP and/or SFM  Domestic  Investments  were
acquired or disposed of for investment  purposes.  Neither the Reporting Persons
nor, to the best of their  knowledge,  any of the other  persons  identified  in
response to Item 2, has any plans or proposals that relate to or would result in
any of the transactions  described in subparagraphs (a) through (j) of Item 4 of
Schedule 13D.

                  The Reporting  Persons reserve the right to acquire,  or cause
to be acquired,  additional securities of the Issuer, to dispose of, or cause to
be disposed,  such securities at any time or to formulate other purposes,  plans
or proposals regarding the Issuer or any of its securities, to the extent deemed
advisable in light of general  investment and trading  policies of the Reporting
Persons, market conditions or other factors.

Item 5.           Interest in Securities of the Issuer.

                           (a)      (i)     Each of QIP, QIHMI,  QIH Management,
SFM LLC  and  Mr.  Druckenmiller  may be  deemed  the  beneficial  owner  of the
2,143,350 Shares (approximately 11.99% of the total number of Shares which would
be  outstanding  assuming the exercise and  conversion of all of the  securities
held for the account of QIP). This number includes (A) 1,963,350 Shares issuable
upon conversion of 75,000 Series B Preferred Shares (as defined herein) held for
the  account of QIP and (B) 180,000  Shares  issuable  upon  exercise of 180,000
warrants held for the account of QIP.

                                    (ii)    Mr.   Soros   may  be   deemed   the
beneficial owner of 2,857,800 Shares  (approximately  15.37% of the total number
of Shares which would be outstanding assuming the exercise and conversion of all
of the  securities  held for the  account  of QIP).  This  number  includes  (A)
1,963,350  Shares issuable upon  conversion of 75,000 Series B Preferred  Shares
held for the  account of QIP;  (B)  180,000  Shares  issuable  upon  exercise of
180,000  warrants held for the account of QIP; (C) 654,450 Shares  issuable upon
conversion  of 25,000  Series B  Preferred  Shares  held for the  account of SFM
Domestic  Investments;  and, (D) 60,000 Shares  issuable upon exercise of 60,000
warrants held for the account of SFM Domestic Investments.

                           (b)      (i)     Each of QIP,  QIHMI,  QIH Management
and SFM LLC (by virtue of the QIP contract) may be deemed to have the sole power
to direct  the voting  and  disposition  of the  2,143,350  Shares  held for the
account of QIP (assuming the conversion of all Series B Preferred Shares and the
exercise of all warrants held for the account of QIP). 

                                    (ii)    Mr. Soros and Mr.  Druckemiller as a
result of their positions with SFM LLC may be deemed to have the shared power to
direct the voting and disposition of the 2,143,350  Shares held for the  account
of QIP  (assuming  the  conversion  of all  Series B  Preferred  Shares  and the
exercise of all warrants held for the account of QIP).

                                            
                                    (iii)   Mr.  Soros  in  his  capacity  as  a
managing member of SFM Domestic Investments may be deemed to have the sole power
to direct the voting and  disposition of the 714,450 Shares held for the account
of SFM Domestic  Investments  (assuming the conversion of all Series B Preferred
Shares and the  exercise of all  warrants  held for the account of SFM  Domestic
Investments).
               

<PAGE>


                                                             Page 11 of 83 Pages

                           (c)      Except for the transactions  listed on Annex
C hereto,  there have been no  transactions  effected with respect to the Shares
since  February  7,  1999 (60  days  prior  to the  date  hereof)  by any of the
Reporting Persons.

                           (d)      (i)     The  shareholders of QIP,  including
Quantum  Industrial  Holdings,  Ltd.,  a British  Virgin  Islands  international
business  company,  have the right to  participate  in the receipt of  dividends
from,  or  proceeds  from the sale of, the Shares held for the account of QIP in
accordance with their ownership interests in QIP.

                                    (ii)    Certain   members  of  SFM  Domestic
Investments  have the right to participate in the receipt of dividends  from, or
proceeds  from the sale of, the  Shares  held for the  account  of SFM  Domestic
Investments.

                           (e)      Not applicable.

Item 6.           Contracts, Arrangements,  Understandings or Relationships with
                  Respect to Securities of the Issuer.

                  On March 29, 1999,  each of QIP and SFM  Domestic  Investments
entered  into a  Series B  Convertible  Preferred  Stock  and  Warrant  Purchase
Agreement  (the  "Series  B  Agreement")  with  the  Issuer  (a copy of which is
attached hereto as Exhibit E and incorporated herein by reference in response to
this Item 6) pursuant to which they  purchased an aggregate of 100,000 shares of
Series B Convertible  Preferred Stock ("Series B Preferred Shares") and warrants
to  purchase,  subject to the terms and  conditions  thereof,  an  aggregate  of
240,000 Shares.

                  Pursuant to Section 1.3 of the Series B Agreement,  the Issuer
is given a put right, which, within a specific time frame, permits the Issuer to
require each of QIP and SFM Domestic  Investments to purchase  additional shares
of convertible preferred stock.

                  Pursuant to Section 7.6 of the Series B Agreement, QIP and SFM
Domestic Investments collectively are entitled to name one representative to the
Issuer's  Board of Directors and are entitled to be  represented  on significant
committees of the Issuer's  Board of Directors,  provided that they own at least
one half of their initial investment.  Neal Moszkowski has been named by QIP and
SFM Domestic Investments to the Issuer's Board of Directors.

                  The foregoing  description  of the Series B Agreement does not
purport to be complete  and is  qualified  in its  entirety by  reference to the
Series B Agreement (attached as Exhibit E to this Initial  Statement),  which is
incorporated herein by reference.

                  On March 29, 1999,  each of QIP and SFM  Domestic  Investments
entered  into  a  Registration   Rights  Agreement  (the  "Registration   Rights
Agreement") with the Issuer (a copy of which is attached hereto as Exhibit F and
incorporated  herein by  reference in response to this Item 6) pursuant to which
the Issuer  has  agreed to grant  registration  rights  with  respect to certain
securities.

                  Pursuant to Section 3 of the  Registration  Rights  Agreement,
QIP and SFM Domestic  Investments  were granted certain rights relating to their
ability to demand  that the Issuer  register  under the  Securities  Act of 1933
unregistered securities of the Issuer held by QIP or SFM Domestic Investments.

                  Pursuant to Section 4 of the  Registration  Rights  Agreement,
QIP and SFM Domestic  Investments were granted certain  piggy-back  registration
rights,  which,  if  exercised,  entitle  QIP and SFM  Domestic  Investments  to
participate in registered offerings by the Issuer.


<PAGE>


                                                             Page 12 of 83 Pages


                  Pursuant to Section 5 of the  Registration  Rights  Agreement,
each of QIP and SFM Domestic Investments may be required to enter into a lock-up
agreement  under  certain  circumstances,  provided  that  entering into such an
agreement will not violate  applicable law or contravene  QIP's and SFM Domestic
Investments' fiduciary duties.

                  Pursuant to Section 6 of the  Registration  Rights  Agreement,
each  of QIP and SFM  Domestic  Investments  will  be  required  to  discontinue
disposition of the Issuer's  securities  upon  receiving  notice from the Issuer
that the Issuer's  prospectus contains an untrue statement of a material fact or
omits to state a material fact required to be stated therein.

                  The foregoing description of the Registration Rights Agreement
does not purport to be complete and is qualified in its entirety by reference to
the  Registration  Rights  Agreement  (attached  as  Exhibit  F to this  Initial
Statement), which is incorporated herein by reference.

                  From  time to time,  each of the  Reporting  Persons  may lend
portfolio securities to brokers,  banks or other financial  institutions.  These
loans  typically  obligate  the borrower to return the  securities,  or an equal
amount of securities of the same class, to the lender and typically provide that
the  borrower  is entitled to  exercise  voting  rights and to retain  dividends
during  the term of the loan.  From time to time,  to the  extent  permitted  by
applicable laws, each of the Reporting Persons may borrow securities,  including
the  Shares,  for  the  purpose  of  effecting,   and  may  effect,  short  sale
transactions,  and may purchase  securities for the purpose of closing out short
positions in such securities.

                  Except as described above,  the Reporting  Persons do not have
any contracts, arrangements, understandings or relationships with respect to any
securities of the Issuer.


Item 7.           Material to be Filed as Exhibits.

                  A.       Power of Attorney dated as of January 1, 1997 granted
by Mr. Soros in favor of Mr. Sean C. Warren and Mr. Michael C. Neus.

                  B.       Power of Attorney dated as of January 1, 1997 granted
by Mr. Druckenmiller in favor of Mr. Sean C. Warren and Mr. Michael C. Neus.

                  C.       Joint  Filing  Agreement  dated  April 8, 1999 by and
among QIP, QIHMI, QIH Management, SFM LLC, Mr. Soros and Mr. Druckenmiller.

                  D.       Power of Attorney  dated May 23, 1996  granted by QIP
in favor of Mr. Gary Gladstein, Mr. Sean Warren and Mr. Michael Neus.

                  E.       Series B  Convertible  Preferred  Stock  and  Warrant
Purchase  Agreement dated March 29, 1999 among the Issuer,  QIP and SFM Domestic
Investments.

                  F.       Registration  Rights  Agreement dated March 29, 1999,
and all  amendments  thereto,  executed by the Issuer for the benefit of QIP and
SFM Domestic Investments.




<PAGE>


                                                             Page 13 of 83 Pages

                                   SIGNATURES

         After  reasonable  inquiry and to the best of my knowledge  and belief,
the  undersigned  certifies that the  information set forth in this Statement is
true, complete and correct.

Date: April 8, 1999

                                     QUANTUM INDUSTRIAL PARTNERS LDC


                                     By:     /S/ SEAN C. WARREN
                                             -----------------------------------
                                             Sean C. Warren
                                             Attorney-in-Fact


                                     QIH MANAGEMENT INVESTOR, L.P.

                                             By:      QIH Management, Inc.,
                                                      its General Partner


                                                      By:     /S/ SEAN C. WARREN
                                                              ------------------
                                                              Sean C. Warren
                                                              Vice President



                                     QIH MANAGEMENT, INC.


                                     By:     /S/ SEAN C. WARREN
                                             -----------------------------------
                                             Sean C. Warren
                                             Vice President


                                     SOROS FUND MANAGEMENT LLC


                                     By:     /S/ SEAN C. WARREN
                                             -----------------------------------
                                             Sean C. Warren
                                             Managing Director


                                     GEORGE SOROS


                                     By:     /S/ SEAN C. WARREN
                                             -----------------------------------
                                             Sean C. Warren
                                             Attorney-in-Fact





<PAGE>


                                                             Page 14 of 83 Pages



                                     STANLEY F. DRUCKENMILLER


                                     By:     /S/ SEAN C. WARREN
                                             -----------------------------------
                                             Sean C. Warren
                                             Attorney-in-Fact





<PAGE>

<TABLE>
<CAPTION>

                                                                                             Page 15 of 83 Pages


                                                     ANNEX A

                            Directors and Officers of Quantum Industrial Partners LDC
     <S>                                      <C>                                          <C>       

     Name/Title/Citizenship                   Principal Occupation                         Business Address
     ----------------------                   --------------------                         ----------------
     Curacao Corporation                      Managing Director of                         Kaya Flamboyan 9     
     Company N.V.                             Netherlands Antilles                         Willemstad           
        Managing Director                     corporations                                 Curacao,             
        (Netherlands Antilles)                                                             Netherlands Antilles 
                                                                                           

     Inter Caribbean Services Limited         Administrative services                      Citco Building        
        Secretary                                                                          Wickhams Cay          
        (British Virgin Islands)                                                           Road Town             
                                                                                           Tortola               
                                                                                           British Virgin Islands
                                                                                           




                                 Directors and Officers of QIH Management, Inc.

     Name/Title/Citizenship                   Principal Occupation                          Business Address
     ----------------------                   --------------------                          ----------------

     Gary Gladstein                           Managing Director of SFM                      888 Seventh Avenue 
     Director and President                   LLC                                           33rd Floor         
     (United States)                                                                        New York, NY  10106
                                                                                            
     Sean C. Warren                           Managing Director of SFM                      888 Seventh Avenue  
     Director, Vice President                 LLC                                           33rd Floor          
     and Secretary                                                                          New York, NY  10106 
     (United States)                                                                        

     Peter Streinger                          Chief Financial Officer of                    888 Seventh Avenue 
     Treasurer                                SFM LLC                                       33rd Floor         
     (United States)                                                                        New York, NY  10106
                                                                                            
     Michael C. Neus                          Assistant General Counsel of                  888 Seventh Avenue   
     Vice President and                       SFM LLC                                       33rd Floor           
     Assistant Secretary                                                                    New York, NY  10106  
     (United States)                                                                        





         To the best of the Reporting Persons' knowledge /1/:

                  (a)      None of the above persons hold any Shares. /1/

                  (b)      None of the above persons has any contracts, arrangements,
understandings or relationships with respect to the Shares. /1/

- ----------
/1/ Certain persons may have an interest in SFM Domestic Investments.

</TABLE>

<PAGE>


                                                             Page 16 of 83 Pages


                                     ANNEX B


                  The  following  is a list of all of the  persons  (other  than
Stanley Druckenmiller) who serve as Managing Directors of SFM LLC. /1/


Scott K. H. Bessent
Walter Burlock
Brian J. Corvese
L. Kevin Dann
Gary Gladstein
Ron Hiram
Robert K. Jermain
David N. Kowitz
Alexander C. McAree
Paul McNulty
Steven Okin
Frank Sica
Sean C. Warren

         Each of the  above-listed  persons  is a United  States  citizen  whose
principal  occupation is serving as Managing Director of SFM LLC, and each has a
business address c/o Soros Fund Management LLC, 888 Seventh Avenue,  33rd Floor,
New York, New York 10106.

         To the best of the Reporting Persons' knowledge:

                  (a) None of the above persons hold any Shares. /1/

                  (b) None of the above persons has any contracts, arrangements,
understandings or relationships with respect to the Shares. /1/












- ----------
/1/ Certain persons may have an interest in SFM Domestic Investments.


<PAGE>


                                                             Page 17 of 83 Pages


                                     ANNEX C

                    RECENT TRANSACTIONS IN THE SECURITIES OF
                        INTEGRA LIFESCIENCES CORPORATION

<TABLE>
<CAPTION>

<S>                                          <C>                <C>                      <C>                 <C>    

                                             Date of             Nature of                Number of
For the Account of                         Transaction          Transaction              Securities          Price
- ------------------                         -----------          -----------              ----------          -----
QIP                                          3/29/99             PURCHASE                 75,000/1/          /3/

                                                                                         180,000/2/

SFM Domestic Investments                     3/29/99             PURCHASE                 25,000/1/          /4/

                                                                                          60,000/2/




- -------------------------

/1/ Shares of Series B Preferred Stock.
/2/ Warrants.
/3/ Total consideration of $7,500,000 was paid for the securities purchased by QIP.
/4/ Total  consideration of $2,500,000 was paid for the securities  purchased by
SFM Domestic Investments.

</TABLE>

<PAGE>
<TABLE>
<CAPTION>


                                                                                                         Page 18 of 83 Pages

                                                        EXHIBIT INDEX

<S>      <C>                                                                                                      <C>    
                                                                                                                  Page No.
                                                                                                                  --------
A.       Power of Attorney dated as of January 1, 1997 granted by Mr. George Soros in favor
         of Mr. Sean C. Warren and Mr. Michael C. Neus.........................................................          19

B.       Power of Attorney dated as of January 1, 1997 granted by Mr. Stanley F. Druckenmiller
         in favor of Mr. Sean C. Warren and Mr. Michael C. Neus.................................................         20

C.       Joint Filing Agreement dated April 8, 1999 by and among Quantum Industrial
         Partners LDC, QIH Management Investor, L.P., QIH Management, Inc., Soros Fund
         Management LLC, Mr. George Soros and Mr. Stanley F. Druckenmiller ...................................           21

D.       Power of Attorney dated May 23, 1996 granted by Quantum Industrial Partners LDC
         in favor of Mr. Gary Gladstein, Mr. Sean Warren and Mr. Michael Neus................................            23

E.       Series B Convertible Preferred Stock and Warrant Purchase Agreement dated March 29,
         1999 by and among Integra LifeSciences Corporation, Quantum Industrial Partners LDC
         and SFM Domestic Investments LLC. ...................................................................           24

F.       Registration Rights Agreement dated March 29, 1999 by and among Integra
         LifeSciences Corporation, Quantum Industrial Partners LDC and SFM Domestic Investments
         LLC. ................................................................................................           62


</TABLE>







                                                             Page 19 of 83 Pages

                                    EXHIBIT A

                                POWER OF ATTORNEY


KNOW ALL MEN BY THESE PRESENTS,  that I, GEORGE SOROS,  hereby make,  constitute
and appoint each of SEAN C. WARREN and MICHAEL C. NEUS, acting individually,  as
my agent and attorney-in-fact for the purpose of executing in my name, (a) in my
personal  capacity or (b) in my capacity as Chairman  of,  member of or in other
capacities  with  Soros  Fund  Management  LLC,  all  documents,   certificates,
instruments,  statements,  filings and agreements ("documents") to be filed with
or  delivered  to any foreign or domestic  governmental  or  regulatory  body or
required or  requested  by any other  person or entity  pursuant to any legal or
regulatory  requirement  relating to the acquisition,  ownership,  management or
disposition of securities or other investments, and any other documents relating
or ancillary  thereto,  including but not limited to, all documents  relating to
filings with the United States  Securities and Exchange  Commission  (the "SEC")
pursuant to the Securities  Act of 1933 or the  Securities  Exchange Act of 1934
(the "Act") and the rules and regulations promulgated thereunder, including: (1)
all documents relating to the beneficial  ownership of securities required to be
filed  with  the SEC  pursuant  to  Section  13(d) or  Section  16(a) of the Act
including, without limitation: (a) any acquisition statements on Schedule 13D or
Schedule  13G and  any  amendments  thereto,  (b) any  joint  filing  agreements
pursuant to Rule  13d-1(f) and (c) any initial  statements  of, or statements of
changes in,  beneficial  ownership of securities on Form 3, Form 4 or Form 5 and
(2) any  information  statements  on Form 13F  required to be filed with the SEC
pursuant to Section 13(f) of the Act.

All past acts of the attorney-in-fact in furtherance of the foregoing are hereby
ratified and confirmed.

This power of attorney shall be valid from the date hereof until revoked by me.

IN  WITNESS  WHEREOF,  I have  executed  this  instrument  as of the  1st day of
January, 1997.




                                /s/ George Soros
                                ------------------------------------
                                GEORGE SOROS








                                                             Page 20 of 83 Pages

                                    EXHIBIT B

                                POWER OF ATTORNEY


KNOW ALL MEN BY THESE PRESENTS,  that I, STANLEY F. DRUCKENMILLER,  hereby make,
constitute  and  appoint  each of SEAN C.  WARREN and  MICHAEL  C. NEUS,  acting
individually,  as my agent and  attorney-in-fact for the purpose of executing in
my name,  (a) in my personal  capacity  or (b) in my capacity as Lead  Portfolio
Manager of, member of or in other capacities with Soros Fund Management LLC, all
documents,  certificates,   instruments,   statements,  filings  and  agreements
("documents")  to be  filed  with  or  delivered  to  any  foreign  or  domestic
governmental  or regulatory body or required or requested by any other person or
entity  pursuant  to  any  legal  or  regulatory  requirement  relating  to  the
acquisition,  ownership,  management  or  disposition  of  securities  or  other
investments,  and any other documents relating or ancillary  thereto,  including
but not limited to, all  documents  relating to filings  with the United  States
Securities and Exchange Commission (the "SEC") pursuant to the Securities Act of
1933 or the  Securities  Exchange  Act of 1934  (the  "Act")  and the  rules and
regulations promulgated thereunder, including: (1) all documents relating to the
beneficial ownership of securities required to be filed with the SEC pursuant to
Section 13(d) or Section 16(a) of the Act including, without limitation: (a) any
acquisition  statements  on  Schedule  13D or  Schedule  13G and any  amendments
thereto,  (b) any joint filing agreements  pursuant to Rule 13d-1(f) and (c) any
initial  statements  of, or  statements of changes in,  beneficial  ownership of
securities  on Form 3, Form 4 or Form 5 and (2) any  information  statements  on
Form 13F required to be filed with the SEC pursuant to Section 13(f) of the Act.

All past acts of the attorney-in-fact in furtherance of the foregoing are hereby
ratified and confirmed.

This power of attorney shall be valid from the date hereof until revoked by me.

IN  WITNESS  WHEREOF,  I have  executed  this  instrument  as of the  1st day of
January, 1997.




                                       /s/ Stanley F. Druckenmiller
                                       -----------------------------------------
                                       STANLEY F. DRUCKENMILLER








                                                             Page 21 of 83 Pages

                                    EXHIBIT C

                             JOINT FILING AGREEMENT

                  The  undersigned  hereby agree that the  statement on Schedule
13D with respect to the Common Stock of Integra  LifeSciences  Corporation dated
April 8, 1999 is, and any amendments  thereto signed by each of the  undersigned
shall be, filed on behalf of each of us pursuant to and in  accordance  with the
provisions of Rule 13d-1(f) under the Securities Exchange Act of 1934.

Date:  April 8, 1999
                                   QUANTUM INDUSTRIAL PARTNERS LDC


                                   By:  /S/ SEAN C. WARREN
                                        ----------------------------------------
                                        Sean C. Warren
                                        Attorney-in-Fact


                                   QIH MANAGEMENT INVESTOR, L.P.

                                   By:      QIH Management, Inc.,
                                            its General Partner


                                            By:   /S/ SEAN C. WARREN
                                                  ------------------------------
                                                  Sean C. Warren
                                                  Vice President


                                   QIH MANAGEMENT, INC.


                                   By:  /S/ SEAN C. WARREN
                                        ----------------------------------------
                                        Sean C. Warren
                                        Vice President


                                   SOROS FUND MANAGEMENT LLC


                                   By:  /S/ SEAN C. WARREN
                                        ----------------------------------------
                                        Sean C. Warren
                                        Managing Director

                                   GEORGE SOROS


                                   By:  /S/ SEAN C. WARREN
                                        ----------------------------------------
                                        Sean C. Warren
                                        Attorney-in-Fact





<PAGE>


                                                             Page 22 of 83 Pages




                                  STANLEY F. DRUCKENMILLER


                                   By:  /S/ SEAN C. WARREN
                                        ----------------------------------------
                                        Sean C. Warren
                                        Attorney-in-Fact










                                                             Page 23 of 83 Pages

                                    EXHIBIT D

                         QUANTUM INDUSTRIAL PARTNERS LDC
                                POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENT,  that the undersigned QUANTUM INDUSTRIAL PARTNERS
LDC (the "Company"), an exempted limited duration company existing and operating
under the laws of the Cayman Islands does, pursuant to a duly adopted resolution
of its Managing Director, hereby designate, constitute and appoint:

                  GARY GLADSTEIN, SEAN WARREN and MICHAEL NEUS

acting,  singly and not  jointly,  as its true and lawful  agent and attorney in
fact for the purpose of  executing  in its name,  all  documents,  certificates,
instruments,  statements,  filings and agreements ("documents") to be filed with
or  delivered  to any foreign or domestic  governmental  or  regulatory  body or
required or  requested  by any other  person or entity  pursuant to any legal or
regulatory  requirement  relating to the acquisition,  ownership,  management or
disposition of securities or other investments, and any other documents relating
or ancillary  thereto,  including but not limited to, all documents  relating to
filings with the United States  Securities and Exchange  Commission  (the "SEC")
pursuant to the Securities  Act of 1933 or the  Securities  Exchange Act of 1934
(the "Act") and the rules and regulations promulgated thereunder, including: (1)
all documents relating to the beneficial  ownership of securities required to be
filed  with  the SEC  pursuant  to  Section  13(d) or  Section  16(a) of the Act
including, without limitation: (a) any acquisition statements on Schedule 13D or
Schedule  13G and  any  amendments  thereto,  (b) any  joint  filing  agreements
pursuant to Rule  13d-1(f) and (c) any initial  statements  of, or statements of
changes in,  beneficial  ownership of securities on Form 3, Form 4 or Form 5 and
(2) any  information  statements  on Form 13F  required to be filed with the SEC
pursuant to Section 13(f) of the Act.

Each  attorney-in-fact  is hereby  authorized and empowered to perform all other
acts and deeds, which he or she in his or her sole discretion deems necessary or
appropriate  to carry out to the fullest  extent the terms and the intent of the
foregoing.  All  prior  acts  of each  attorney-in-fact  in  furtherance  of the
foregoing are hereby ratified and confirmed.

IN WITNESS WHEREOF, the Company has caused this document to be execute this 23rd
day of May, 1996.

                                   QUANTUM INDUSTRIAL PARTNERS LDC


                                   /s/ Curacao Corporation Company N.V.
                                   ---------------------------------------------
                                   Curacao Corporation Company N.V.
                                   Managing Director








                                                             Page 24 of 83 Pages


                                   EXHIBIT E


________________________________________________________________________________








                      SERIES B CONVERTIBLE PREFERRED STOCK
                         AND WARRANT PURCHASE AGREEMENT


                                      among


                        INTEGRA LIFESCIENCES CORPORATION,



                        QUANTUM INDUSTRIAL PARTNERS LDC,


                                       and


                          SFM DOMESTIC INVESTMENTS LLC



                  ______________________________________________



                              Dated: March 29, 1999

                  ______________________________________________







________________________________________________________________________________



<PAGE>

                                                                               
<TABLE>
<CAPTION>
                                                                                        Page 25 of 83 Pages


                                TABLE OF CONTENTS

<S>                   <C>                                                                             <C>   
                                                                                                      Page
                                                                                                      ____

SECTION I.            PURCHASE AND SALE OF SERIES BPREFERRED STOCK
                      AND WARRANTS.......................................................................6
           1.1        Purchase and Sale of Series B Preferred Stock and Warrants.........................6
           1.2        Certificate of Designation.........................................................7
           1.3        Additional Preferred Stock.........................................................7
           1.4        Closing............................................................................7

SECTION II.           REPRESENTATIONS AND WARRANTIES OF THE COMPANY......................................8
           2.1        Corporate Existence and Power......................................................8
           2.2        Corporate Authorization; No Contravention..........................................8
           2.3        Governmental Authorization; Third Party Consents...................................8
           2.4        Binding Effect.....................................................................9
           2.5        Litigation.........................................................................9
           2.6        Compliance with Laws...............................................................9
           2.7        Capitalization....................................................................10
           2.8        No Default or Breach..............................................................11
           2.9        Taxes.............................................................................11
           2.10       Financial Statements..............................................................11
           2.11       No Material Adverse Change; Ordinary Course of Business...........................11
           2.12       SEC Documents.....................................................................12
           2.13       Investment Company................................................................12
           2.14       Private Offering..................................................................12
           2.15       Employee Benefit Plans............................................................12
           2.16       Title to Assets...................................................................12
           2.17       Intellectual Property.............................................................13
           2.18       Trade Relations...................................................................13
           2.19       Contracts and Other Agreements....................................................14
           2.20       Liabilities.......................................................................14
           2.21       Broker's, Finder's or Similar Fees................................................14
           2.22       Disclosure; Agreement and Other Documents.........................................14
           2.23       NeuroCare Acquisition Agreement...................................................15


<PAGE>

                                                                                       Page 26 of 83 Pages

SECTION III.          REPRESENTATIONS AND WARRANTIES OF THE
                      PURCHASERS........................................................................15
           3.1        Existence and Power...............................................................15
           3.2        Authorization; No Contravention...................................................15
           3.3        Governmental Authorization; Third Party Consents..................................15
           3.4        Binding Effect....................................................................15
           3.5        Purchase for Own Account..........................................................16
           3.6        Accreditation; Sophistication; Other Securities Laws Matters......................16
           3.7        Broker's, Finder's or Similar Fees................................................16

SECTION IV.           CONDITIONS TO THE OBLIGATION OF THE PURCHASERS
                      TO CLOSE    ......................................................................17
           4.1        Representations and Warranties....................................................17
           4.2        Compliance with this Agreement....................................................17
           4.3        Secretary's Certificate...........................................................17
           4.4        Officers' Certificate.............................................................17
           4.5        Documents.........................................................................18
           4.6        Filing of Certificate of Designation..............................................18
           4.7        Registration Rights Agreement.....................................................18
           4.8        Opinion of Counsel................................................................18
           4.9        Approval of Counsel to the Purchasers.............................................18
           4.10       Purchased Shares..................................................................18
           4.11       Warrants..........................................................................18
           4.12       Consents and Approvals............................................................18
           4.13       No Litigation.....................................................................19
           4.14       No Material Judgment or Order.....................................................19
           4.15       No Material Adverse Change........................................................19
           4.16       Neurocare Acquisition.............................................................19

SECTION V.            CONDITIONS TO THE OBLIGATIONOF THE COMPANY TO
                      CLOSE.............................................................................19
           5.1        Representations and Warranties....................................................19
           5.2        Compliance with this Agreement....................................................20
           5.3        Registration Rights Agreement.....................................................20
           5.4        Consents and Approvals............................................................20
           5.5        Payment of Purchase Price.........................................................20
           5.6        No Material Judgment or Order.....................................................20
           5.7        Opinion of Counsel................................................................20

SECTION VI.           INDEMNIFICATION...................................................................21
           6.1        Indemnification...................................................................21
           6.2        Notification......................................................................21
           6.3        Registration Rights Agreement.....................................................22

<PAGE>

                                                                                       Page 27 of 83 Pages

SECTION VII.          AFFIRMATIVE COVENANTS.............................................................22
           7.1        Preservation of Existence.........................................................22
           7.2        Delivery of 1998 Audited Financial Statements.....................................23
           7.3        Financial Statements and Other Information........................................23
           7.4        Reservation of Shares.............................................................24
           7.5        Registration and Listing..........................................................25
           7.6        Board Representation..............................................................25
           7.7        Director and Officer Liability Insurance..........................................25

SECTION VIII.         TERMINATION OF AGREEMENT..........................................................25
           8.1        Termination.......................................................................25
           8.2        Survival..........................................................................26

SECTION IX.           MISCELLANEOUS.....................................................................26
           9.1        Survival of Representations and Warranties........................................26
           9.2        Notices...........................................................................27
           9.3        Successors and Assigns............................................................28
           9.4        Amendment and Waiver..............................................................29
           9.5        Counterparts......................................................................29
           9.6        Headings..........................................................................29
           9.7        GOVERNING LAW.....................................................................29
           9.8        Severability......................................................................29
           9.9        Rules of Construction.............................................................29
           9.10       Entire Agreement..................................................................29
           9.11       Fees..............................................................................30
           9.12       Publicity; Confidentiality........................................................30
           9.13       Further Assurances................................................................31
           9.14       Schedules.........................................................................31

</TABLE>

<PAGE>

                                                             Page 28 of 83 Pages

EXHIBITS
- --------

A                     Form of Warrant
B                     Certificate of Designation
C                     Amended and Restated Registration Rights Agreement
D                     Form of Drinker Biddle & Reath Opinion
E                     Form of Paul, Weiss, Wharton & Garrison Opinion


SCHEDULES
- ---------

1                     Purchased Shares and Warrants and Purchase Price
2.5                   Litigation
2.7                   Capitalization
2.8                   No Default or Breach
2.11                  No Material Adverse Change; Ordinary Course of Business
2.16                  Title to Assets
2.17(a)               Intellectual Property
2.17(b)               Infringements of Integra
2.17(c)               Intellectual Property Litigation
2.18                  Trade Relations
2.19                  Contracts and other Agreements





<PAGE>

                                                             Page 29 of 83 Pages

                      

                      SERIES B CONVERTIBLE PREFERRED STOCK
                         AND WARRANT PURCHASE AGREEMENT


                  THIS SERIES B CONVERTIBLE PREFERRED STOCK AND WARRANT PURCHASE
AGREEMENT  (this  "Agreement") is made as of March 29, 1999 by and among Integra
                   ---------       
LifeSciences  Corporation,  a Delaware corporation ("Integra"),  and the several
                                                     -------
purchasers listed on Schedule 1 hereto (the "Purchasers").
                     ----------              ----------

                  WHEREAS,  Integra  has agreed to issue and sell to each of the
Purchasers,  and each of the Purchasers has agreed to purchase from Integra, for
the  aggregate  purchase  price  set forth  opposite  such  Purchaser's  name on
Schedule 1 hereto,  (i) the  aggregate  number of shares of Series B Convertible
- ----------
Preferred  Stock,  par value $.01 per share, of Integra (the "Series B Preferred
                                                              ------------------
Stock") set forth opposite such Purchaser's name on Schedule 1 hereto,  and (ii)
- -----                                               ----------
the warrant (the  "Warrant")  to purchase,  subject to the terms and  conditions
                   -------
thereof,  the  aggregate  number of shares of Common  Stock,  par value $.01 per
share, of Integra (the "Common Stock") set forth opposite such  Purchaser's name
                        ------------
on Schedule 1 hereto, at an exercise price of $3.82 per share,  containing terms
   ----------
and conditions set forth in the form of warrant attached hereto as Exhibit A.
                                                                   ---------

                  NOW,  THEREFORE,  in  consideration  of the  mutual  terms and
conditions  herein  contained,  and for good  and  valuable  consideration,  the
receipt of which is hereby  acknowledged,  the parties  hereto,  intending to be
legally bound, hereby agree as follows:


                                   DEFINITIONS

                  For all purposes of this Agreement, unless otherwise expressly
provided,  (a) the terms defined in this  Definitions  section have the meanings
assigned to them herein and include the plural as well as the singular,  (b) all
accounting terms not otherwise  defined herein have the meanings  assigned under
generally  accepted  accounting   principles  in  the  United  States,  (c)  all
references in this Agreement to designated "Sections" and other subdivisions are
to the designated Sections and other subdivisions of the body of this Agreement,
(d) pronouns of either gender or neuter shall include, as appropriate, the other
pronoun forms,  and (e) the words "herein",  "hereof" and other words of similar
import  refer to this  Agreement as a whole and not to any  particular  Article,
Section or other subdivision.

                  As used in this  Agreement,  the following  definitions  shall
apply:

                  "Additional   Preferred  Stock"  shall  mean  the  convertible
                   -----------------------------
preferred  stock issued pursuant to Section 1.3 having  substantially  identical
terms as the Series B Preferred Stock.

<PAGE>

                                                             Page 30 of 83 Pages

                  "Action" means any action, complaint, petition, investigation,
                   ------
suit or other  proceeding,  whether civil or criminal,  in law or in equity,  or
before any arbitrator or Governmental Entity.

                  "Affiliate"  shall mean any Person who is an  "affiliate"  (as
                   ---------
defined in Rule 12b-2 of the General  Rules and  Regulations  under the Exchange
Act) of, and any Person  controlling,  controlled  by, or under  common  control
with, any Purchaser. For the purposes of this Agreement,  "control" includes the
ability to have investment  discretion through contractual means or by operation
of law.

                  "Agreement"  means this  Agreement as the same may be amended,
                   ---------
supplemented or modified in accordance with the terms hereof.

                  "Audited  Financial  Statements"  has the meaning set forth in
                   ------------------------------
Section 7.2 of this Agreement.

                  "Board of Directors" means the Board of Directors of Integra.
                   ------------------

                  "Business"  means the  business of Integra and shall be deemed
                   --------
to include any of the following incidents of such business:  income, operations,
condition (financial or other), assets, properties and liabilities.

                  "Business Day" means any day other than a Saturday,  Sunday or
                   ------------
other day on which  commercial  banks in the State of New York are authorized or
required by law or executive order to close.

                  "By-laws"  means the amended and restated  by-laws of Integra,
                   -------
as the same may have been amended and as in effect on the Closing Date.

                  "CEO  Certificate" has the meaning set forth in Section 1.3 of
                   ----------------
this Agreement.

                  "Certificate   of   Designation"   means  the  Certificate  of
                   ------------------------------
Designation with respect to the Series B Preferred Stock adopted by the Board of
Directors  and filed with the  Secretary of State of the State of Delaware on or
before the Closing Date substantially in the form attached hereto as Exhibit B.

                  "Certificate of Incorporation"  means the Amended and Restated
                   ----------------------------
Certificate of Incorporation of Integra,  as the same has been amended and as in
effect on the Closing Date.

                  "Closing"  has the  meaning  set forth in Section  1.4 of this
                   -------
Agreement.
                  
                  "Closing Date" means the date specified in Section 1.4 of this
                   ------------
Agreement.

                  "Code" means the Internal Revenue Code of 1986, as amended, or
                   ----
any successor statute thereto.

<PAGE>

                                                             Page 31 of 83 Pages

                  "Commission"  means the Securities and Exchange  Commission or
                   ----------
any similar agency then having jurisdiction to enforce the Securities Act.

                  "Common  Stock"  means the  Common  Stock,  par value $.01 per
                   -------------
share,  of Integra and any other  capital stock of Integra into which such stock
is reclassified or reconstituted.

                  "Condition of Integra" means the assets, business, properties,
                   --------------------
operations or financial  condition of Integra and the  Subsidiaries,  taken as a
whole.

                  "Contract" means any agreement, arrangement, bond, commitment,
                   --------
franchise,  indemnity,  indenture,  instrument, lease, license or understanding,
whether or not in writing.

                  "Contractual   Obligations"   means  as  to  any  Person,  any
                   -------------------------
provision  of  any  security   issued  by  such  Person  or  of  any  agreement,
undertaking, contract, indenture, mortgage, deed of trust or other instrument to
which such Person is a party or by which it or any of its property is bound.

                  "Conversion Price" has the meaning set forth in Section 1.3 of
                   ----------------
this Agreement.

                  "Encumbrance" means any claim, charge, easement,  encumbrance,
                   -----------
lease,  covenant,  security interest,  lien, option,  pledge,  rights of others,
restriction  (whether on voting,  sale,  transfer,  disposition  or  otherwise),
whether imposed by agreement,  understanding,  law, equity or otherwise,  except
for any restrictions on transfer  generally  arising under any applicable United
States federal or state securities law.

                  "Environmental  Laws"  means  federal,  state and local  laws,
                   -------------------
principles of common law,  regulations  and codes,  as well as orders,  decrees,
judgments or injunctions  issued,  promulgated,  approved or entered  thereunder
relating  to  pollution,  protection  of the  environment  or public  health and
safety.

                  "ERISA" means the Employee  Retirement  Income Security Act of
                   -----
1974, as amended (or any successor statute thereto).

                  "Exchange Act" means the  Securities  Exchange Act of 1934, as
                   ------------
amended (or any successor statute thereto), and the rules and regulations of the
Commission promulgated thereunder.

                  "Financial  Statements"  has the  meaning set forth in Section
                   ---------------------
2.10 of this Agreement.

<PAGE>
                                                             Page 32 of 83 Pages

                  "GAAP"  means  generally  accepted  United  States  accounting
                   ----
principles in effect from time to time.

                  "Governmental  Authority"  means the  government of any state,
                   -----------------------
city,  locality or other political  subdivision  thereof,  any entity exercising
executive,  legislative,  judicial, regulatory or administrative functions of or
pertaining  to  government,  and  any  corporation  or  other  entity  owned  or
controlled,  through  stock or capital  ownership  or  otherwise,  by any of the
foregoing.

                  "Governmental  Entity"  means any  government  or any  agency,
                   --------------------
bureau, board, commission,  court, department,  official, political subdivision,
tribunal  or other  instrumentality  of any  government  of or within the United
States, whether federal, state or local.

                  "Initial  Term" has the  meaning  set forth in Section  1.3 of
                   -------------
this Agreement.

                  "Law"  means any  constitutional  provision,  statute or other
                   ---
law, rule,  regulation,  or  interpretation  of any Governmental  Entity and any
Order.

                  "Liabilities"  has the  meaning  set forth in Section  2.20 of
                   -----------
this Agreement.

                  "Lien"   means   any   mortgage,   deed  of   trust,   pledge,
                   ----
hypothecation, assignment, encumbrance, lien (statutory or other) or preference,
priority,  right or other security  interest or preferential  arrangement of any
kind  or  nature  whatsoever  (excluding  preferred  stock  and  equity  related
preferences) including,  without limitation,  those created by, arising under or
evidenced  by any  conditional  sale or other  title  retention  agreement,  the
interest of a lessor under a Capital Lease  Obligation,  or any financing  lease
having substantially the same economic effect as any of the foregoing.

                  "Loss" means any action, cost, damage, disbursement,  expense,
                   ----
liability,  loss,  deficiency,  diminution  in  value,  obligation,  penalty  or
settlement  of  any  kind  or  nature,  whether  foreseeable  or  unforeseeable,
including  but not limited  to,  interest or other  carrying  costs,  penalties,
legal,  accounting  and other  professional  fees and  expenses  incurred in the
investigation, collection, prosecution and defense of claims and amounts paid in
settlement,  that may be imposed on or  otherwise  incurred  or  suffered by the
specified Person.

                  "NASDAQ"  means the  Nasdaq  National  Market of the  National
                   ------
Association of Securities Dealers, Inc. Automated Quotation System.

<PAGE>

                                                             Page 33 of 83 Pages

                  "NeuroCare  Acquisition  Agreement"  means the Asset  Purchase
                   ---------------------------------
Agreement  dated the date hereof between the Company,  Integra  NeuroCare LLC, a
Delaware limited  liability company and an indirect  wholly-owned  subsidiary of
the Company ("IN LLC"),  Redmond  NeuroCare  LLC, a Delaware  limited  liability
company and a wholly-owned subsidiary of IN LLC, Heyer-Schulte NeuroCare,  L.P.,
a Delaware limited  partnership ("HSN, LP"), and Neuro  Navigational,  L.L.C., a
Delaware limited liability company and a wholly-owned subsidiary of HSN, LP.

                  "Order" mans any decree, injunction, judgement, order, ruling,
                   -----
assessment or writ of any Governmental Entity.

                  "Person" means any individual, firm, corporation, partnership,
                   ------
limited liability company,  trust,  incorporated or unincorporated  association,
joint venture,  joint stock company,  Governmental  Authority or other entity of
any kind,  and shall  include any  successor  (by merger or  otherwise)  of such
entity.

                  "Purchased Shares" has the meaning set forth in Section 1.1 of
                   ----------------
this Agreement.

                  "Purchasers"  has the  meaning  ascribed  to such  term in the
                   ----------
recital to this Agreement.

                  "Put  Right" has the  meaning set forth in Section 1.3 of this
                   ----------
Agreement.

                  "Registration  Rights Agreement" means the Registration Rights
                   ------------------------------
Agreement substantially in the form attached hereto as Exhibit C.
                                                       ---------

                  "Requirements of Law" means as to any Person, any law, treaty,
                   -------------------
rule,  regulation,  right,  privilege,  qualification,  license or  franchise or
determination of an arbitrator or a court or other  Governmental  Authority or a
stock  exchange,  in each case  applicable or binding upon such Person or any of
its  property  or to which  such  Person or any of its  property  is  subject or
pertaining to any or all of the transactions contemplated or referred to herein.

                  "SEC" means the  Securities  and  Exchange  Commission  or any
                   ---
successor entity.

                  "SEC  Documents"  means  all  registration  statements,  proxy
                   --------------
statements,  reports and other  documents  required to be filed by Integra under
the  Securities  Act or the Exchange  Act, and all  amendments  and  supplements
thereto, filed by Integra with the Commission since December 31, 1997.

<PAGE>

                                                             Page 34 of 83 Pages

                  "Second Term" has the meaning set forth in Section 1.3 to this
                   -----------
Agreement.

                  "Securities"  means the Purchased Shares, the shares of Common
                   ----------
Stock  issuable  upon  conversion  of the Purchased  Shares,  the Warrants,  the
Warrant Shares and the Additional Preferred Shares.

                  "Securities  Act" means the Securities Act of 1933, as amended
                   ---------------
(or any  successor  statute  thereto),  and the  rules  and  regulations  of the
Commission promulgated thereunder.

                  "Series B Preferred  Stock" has the  meaning  assigned to such
                   -------------------------
term in the recital to this Agreement.

                  "Subsidiary"  means, as of the relevant date of determination,
                   ----------
with respect to any Person,  a corporation  or other entity of which 50% or more
of the voting power of the outstanding  voting equity  securities or 50% or more
of the outstanding economic equity interest is held, directly or indirectly,  by
such Person. Unless otherwise qualified,  or the context otherwise requires, all
references to a "Subsidiary" or to  "Subsidiaries" in this Agreement shall refer
to a Subsidiary or Subsidiaries of Integra.

                  "Transaction  Documents" means  collectively,  this Agreement,
                   ----------------------
the  Warrants,  the  Certificate  of  Designation  and the  Registration  Rights
Agreement.

                  "Warrant  Shares"  has the meaning set forth in Section 1.1 of
                   ---------------
this Agreement.

                  "Warrants"  has  the  meaning  ascribed  to  such  term in the
                   --------
recital to this Agreement.

SECTION I.        PURCHASE AND SALE OF SERIES B
                  PREFERRED STOCK AND WARRANTS

                  I.1  Purchase  and  Sale  of  Series  B  Preferred  Stock  and
                       ---------------------------------------------------------
Warrants.  Subject to the terms and conditions herein set forth,  Integra agrees
- --------
to issue and sell to each of the Purchasers,  and each of the Purchasers  agrees
that it will purchase from Integra,  for the aggregate  purchase price set forth
opposite such  Purchaser's  name on Schedule 1 hereto,  on the Closing Date, (i)
                                    ----------
the aggregate  number of shares of Series B Preferred  Stock set forth  opposite
such  Purchaser's  name on  Schedule  1 hereto  (all of the  shares  of Series B
                            -----------
Preferred  Stock being  purchased  pursuant  hereto being  referred to herein as
"Purchased  Shares"),  and (ii) the Warrant to purchase the aggregate  number of
 -----------------
shares of Common Stock set forth  opposite such  Purchaser's  name on Schedule 1
                                                                      ----------
hereto (all of the shares of Common Stock issuable upon exercise of the Warrants
being  purchased  pursuant  hereto  being  referred  to herein  as the  "Warrant
                                                                         -------
Shares").
- ------

<PAGE>

                                                             Page 35 of 83 Pages

                  I.2 Certificate of Designation. The Purchased Shares will have
                      --------------------------
the  rights,   preferences,   privileges  and  restrictions  set  forth  in  the
Certificate of Designation of Series B Preferred Stock to Integra's  Certificate
of   Incorporation   attached   hereto  as  Exhibit  A  (the   "Certificate   of
Designation"),  which shall be filed by Integra  with the  Secretary of State of
the State of Delaware prior to the Closing (as hereinafter defined).

                  I.3 Additional Preferred Stock
                      --------------------------

                      (a) At any time  within  180 days after the  Closing  Date
(the "Initial Term") on 14 days written notice, Integra will have the right (the
      ------------
"Put  Right") to require  the  Purchasers  (or  certain  Affiliates  thereof) to
 ----------
purchase up to an additional  $2,000,000 of convertible  preferred  stock having
substantially  identical  terms as the  Series B  Preferred  Stock  ("Additional
                                                                      ----------
Preferred  Stock"),  with  each  Purchaser  purchasing  that  proportion  of the
- ----------------
Additional  Preferred  Stock  equal to such  Purchaser's  proportionate  initial
investment in the Series B Preferred  Stock,  provided that the conversion price
for such  Additional  Preferred  Stock  shall be equal to the  lesser of (i) the
Conversion  Price,  which initially shall be $3.82 per share of Common Stock, as
adjusted and then in effect (the "Conversion Price") or (ii) the average closing
                                  ----------------
price of  Integra's  Common  Stock for the ten (10) trading days ending two days
prior to the date of issuance of the Additional Preferred Stock.

                      (b) If the Initial  Term  expires  without the exercise of
the Put Right by Integra,  such Put Right will  continue for an  additional  180
days  (the  "Second  Term"),  subject  to the  receipt  by the  Purchasers  of a
             ------------
certificate from the Chief Executive Officer of Integra (the "CEO  Certificate")
                                                              ----------------
certifying that the representations  and warranties  contained in Section III of
this Agreement are true and correct in all material  respects as of the exercise
date of the Put Right as if made on and as of such date and as if all references
to Purchased Shares include the Additional Preferred Stock, and that no material
adverse  change  in the  Condition  of  Integra  (other  than  operating  losses
consistent with the historic  results of Integra) has occurred since the Closing
Date.

                  I.4 Closing.  Unless  this  Agreement  shall  have  terminated
                      -------
pursuant  to  Section  VIII and  subject  to the  satisfaction  or waiver of the
conditions  set forth in Sections IV and V (except for Sections  4.10,  4.11 and
5.5,  which  shall  occur   simultaneously  with  the  Closing  (as  hereinafter
defined)),  the closing of the purchase and issuance of the Purchased Shares and
the Warrants  (the  "Closing")  shall take place at the offices of Paul,  Weiss,
                     -------
Rifkind, Wharton & Garrison, at 10:00 a.m., local time, on March 29, 1999, or at
such time and on such date that Integra and the  Purchasers may agree in writing
(the  "Closing  Date").  On the  Closing  Date,  Integra  shall  deliver  to the
       -------------
Purchasers (a) stock certificates  representing the Purchased Shares and (b) the
Warrants,  against  delivery  by the  Purchasers  to  Integra  of the  aggregate
purchase price therefor by wire transfer of immediately available funds.

<PAGE>

                                                             Page 36 of 83 Pages

SECTION II.       REPRESENTATIONS AND WARRANTIES OF THE COMPANY
                  ---------------------------------------------

                  Integra represents and warrants to the Purchasers as follows:

                  II.1     Corporate  Existence and  Power.  Each of Integra and
                           -------------------------------
its  Subsidiaries  (a)  is a  corporation  or  limited  liability  company  duly
incorporated and organized, validly existing and in good standing under the laws
of the jurisdiction of its  incorporation;  (b) has all requisite  corporate (or
limited liability  company) power and authority to own and operate its property,
to lease the property it operates as lessee and to conduct the business in which
it is currently engaged as described in the SEC Documents; (c) is duly qualified
as a foreign  corporation  or other entity,  licensed and in good standing under
the laws of each  jurisdiction  in which its  ownership,  lease or  operation of
property or the conduct of its business requires such  qualification,  except to
the extent that the failure to do so or be so would not have a material  adverse
effect on the  Condition of Integra;  and (d) has the  requisite  corporate  (or
limited liability  company) power and authority to execute,  deliver and perform
its  obligations  under  this  Agreement  and  each  of  the  other  Transaction
Documents.

                  II.2     Corporate   Authorization;   No  Contravention.   The
                           ----------------------------------------------
execution, delivery and performance by Integra of this Agreement and each of the
other  Transaction  Documents  and  the  transactions  contemplated  hereby  and
thereby,  including,  without limitation, the sale, issuance and delivery of the
Securities  (a)  are  within  Integra's  corporate  power  and  have  been  duly
authorized by all necessary  corporate action of Integra;  (b) do not contravene
the terms of the Certificate of Incorporation or By-laws,  or any organizational
or governing  documents,  or any amendment thereof, of the Subsidiaries;  (c) do
not violate,  conflict with or result in any breach or  contravention  of or the
creation of any Lien under,  any material  Contractual  Obligation of Integra or
any of its Subsidiaries,  or any Requirement of Law applicable to Integra or any
of its  Subsidiaries;  and (d) do not violate any  judgment,  injunction,  writ,
award,  decree  or  order  of  any  nature   (collectively,   "Orders")  of  any
Governmental  Authority  against,  or  binding  upon,  Integra  or  any  of  the
Subsidiaries  except for those  Orders the  violation  of which would not have a
material adverse effect on the Condition of Integra.  Neither Integra nor any of
its  Subsidiaries  previously  entered into any agreement  which is currently in
effect or by which Integra is currently bound, granting any rights to any Person
which  are  inconsistent  with the  rights  to be  granted  by  Integra  in this
Agreement and each of the other Transaction Documents.

                  II.3     Governmental  Authorization;  Third  Party  Consents.
                           ---------------------------
Other than (a) the filing and  approval  of an  application  for the  listing on
NASDAQ of the shares of Common Stock  issuable upon  conversion of the Purchased
Shares and the exercise of the Warrants,  (b) the filing of the  Certificate  of

<PAGE>

                                                             Page 37 of 83 Pages

Designation,  (c) those required  pursuant to the applicable state securities or
"blue sky" laws,  with respect to the offer and sale of the  Securities  and (d)
with respect to the performance by Integra of the Registration Rights Agreement,
the  registration of the Registrable  Securities (as defined in the Registration
Rights  Agreement)  covered thereby with the Commission and the  registration or
qualification  of such  Registrable  Securities  and other  filings  pursuant to
applicable  state   securities  or  "blue  sky"  laws,  no  approval,   consent,
compliance,  exemption,  authorization,  or other  action  by, or notice  to, or
filing with, any Governmental Authority or any other Person, including,  without
limitation, any approval or authorization of Integra's stockholders, any further
approval of the Board of Directors or any approval of NASDAQ,  and no lapse of a
waiting  period  under a  Requirement  of  Law,  is  necessary  or  required  in
connection  with the  execution,  delivery or  performance  (including,  without
limitation,  the sale,  issuance and delivery of the  Securities)  by Integra of
this Agreement,  each of the other  Transaction  Documents and the  transactions
contemplated hereby or thereby.

                  II.4     Binding Effect. This Agreement and each of the  other
                           --------------
Transaction  Documents  have been duly  executed  and  delivered  by Integra and
constitute  the legal,  valid and binding  obligations  of Integra,  enforceable
against Integra in accordance with their terms,  except as enforceability may be
limited  by  applicable  bankruptcy,  insolvency,   reorganization,   fraudulent
conveyance or transfer,  moratorium or similar laws affecting the enforcement of
creditors'  rights  generally and by general  principles  of equity  relating to
enforceability  (regardless  of whether  considered in a proceeding at law or in
equity).

                  II.5     Litigation. Except as set forth in the SEC Documents,
                           ----------
the Financial  Statements  (including  the draft notes thereto) or Schedule 2.5,
                                                                   ------------
there are no  actions,  suits,  proceedings,  claims,  complaints,  disputes  or
investigations  pending or  threatened,  at law, in equity,  in  arbitration  or
before any Governmental Authority against Integra or any of its Subsidiaries and
with respect to which Integra or any of its  Subsidiaries  is responsible by way
of indemnity or  otherwise,  which would,  if adversely  determined,  (a) have a
material  adverse  effect on the  Condition  of  Integra  or (b) have an adverse
effect on the ability of Integra to perform its obligations under this Agreement
and each of the other  Transaction  Documents.  No Order has been  issued by any
court or other Governmental Authority against Integra or any of its Subsidiaries
purporting to enjoin or restrain the execution,  delivery or performance of this
Agreement or any of the other Transaction Documents.

                  II.6     Compliance with Laws.
                           --------------------

                           (a)      Each of Integra and its  Subsidiaries  is in
compliance with all  Requirements  of Law in all respects,  except to the extent
that the  failure  to  comply  with  such  Requirements  of Law would not have a
material adverse effect on the Condition of Integra.

<PAGE>

                                                             Page 38 of 83 Pages

                           (b)      (i) Each of Integra and its Subsidiaries has
all  licenses,  permits,  orders  or  approvals  of any  Governmental  Authority
(collectively,  "Permits")  that are material to or necessary for the conduct of
the business of Integra in the manner described in the SEC Documents,  except to
the  extent  that the  failure  to have such  Permits  would not have a material
adverse effect on the Condition of Integra;  (ii) such Permits are in full force
and effect;  and (iii) no violations are or have been recorded in respect of any
Permit.

                           (c)      The property,  assets and  operations at any
time owned or leased by Integra have been in compliance in all material respects
with all applicable  Environmental Laws, while so owned or leased, except to the
extent that the failure to comply with such  Environmental Laws would not have a
material adverse effect on the Condition of Integra.

                  II.7     Capitalization.
                           --------------

                           (a)      The  authorized  capital stock of Integra at
the close of business on March 22, 1999  consisted of (x)  60,000,000  shares of
Common Stock,  of which  15,730,933  shares are issued and  outstanding  and (y)
15,000,000  shares of preferred  stock,  par value $.01 per share,  of which (i)
2,000,000  shares have been  designated as Series A Preferred Stock and of which
500,000  shares are issued and  outstanding  and (ii)  120,000  shares have been
designated  as Series B  Preferred  Stock and of which no shares  are issued and
outstanding.  Integra has reserved an  aggregate  of 2,617,801  shares of Common
Stock for issuance upon conversion of the Purchased Shares and 240,000 shares of
Common Stock for issuance upon exercise of the Warrants.  Except as set forth in
Schedule 2.7,  there are no options,  warrants,  conversion  privileges or other
- ------------
rights presently outstanding to purchase or otherwise acquire any authorized but
unissued or unauthorized shares or treasury shares of Integra's capital stock.

                           (b)      There has been no change in the  authorized,
issued and  outstanding  capital stock of Integra in the interval  between March
22, 1999 and the Closing Date, except for shares of Common Stock issued upon the
exercise of warrants or options, or purchased by Integra pursuant to its current
share repurchase program.

                           (c)      The  Purchased  Shares  are duly  authorized
and,  when issued and sold to the  Purchasers  after payment  therefor,  will be
validly issued,  fully paid and  nonassessable by Integra.  The shares of Common
Stock issuable upon  conversion of the Purchased  Shares and the exercise of the
Warrants are duly  authorized and, when issued in compliance with the provisions
of  this  Agreement,  the  Certificate  of  Incorporation,  the  Certificate  of
Designation  (in the case of the shares of Common Stock issuable upon conversion

<PAGE>
                                                             Page 39 of 83 Pages

of the  Purchased  Shares) and the Warrants (in the case of the Warrant  Shares)
will be validly issued,  fully paid and nonassessable by Integra. The issued and
outstanding  shares of Common  Stock are all duly  authorized,  validly  issued,
fully paid and nonassessable by Integra,  and were issued in compliance with the
registration and qualification requirements of all applicable federal securities
laws.

                  II.8     No Default or Breach. Except as set forth in Schedule
                           --------------------                         --------
2.8,  neither Integra nor any of its Subsidiaries has received notice of, and is
- ---
not in,  default  under or with respect to any,  Contractual  Obligation  in any
respect,  which,  individually or together with all such defaults,  could have a
material  adverse effect on the Condition of Integra,  or which could materially
adversely  affect the ability of Integra to perform its  obligations  under this
Agreement or any of the other Transaction Documents.

                  II.9     Taxes. Each of Integra and its Subsidiaries has filed
                           -----
or caused to be filed,  or has properly  filed  extensions  for, all tax returns
which are  required  to be filed for  federal,  state,  local  and  foreign  tax
purposes  and has paid or caused to be paid all taxes  required to be paid by it
and all  assessments  received  by it to the extent  that such taxes have become
due,  except  taxes the  validity or amount of which is being  contested in good
faith by appropriate  proceedings  and with respect to which  adequate  reserves
have been set aside.  Each of Integra and its Subsidiaries has paid or caused to
be paid, or has established reserves that are adequate in all material respects,
for all tax  liabilities  applicable  to Integra  and its  Subsidiaries  for all
fiscal  years  which  have not  been  examined  and  reported  on by the  taxing
authorities (or closed by applicable statutes).

                  II.10    Financial   Statements.    Integra   has   heretofore
                           ----------------------
delivered  to  the   Purchasers   true  and  correct  copies  of  its  unaudited
consolidated  financial  statements (balance sheet and statements of operations,
cash flows and shareholders' equity,  together with draft notes thereto) for the
fiscal year ended and as at December 31, 1998 (the "Financial Statements").  The
                                                    --------------------
Financial  Statements  comply in all material  respects with the requirements of
the Exchange  Act and have been  prepared in  accordance  with GAAP applied on a
consistent basis throughout the periods indicated and with each other, except as
may be indicated therein or in the draft notes thereto. The Financial Statements
fairly present the consolidated financial condition,  operating results and cash
flows of  Integra  as of the  respective  dates and for the  respective  periods
indicated in accordance with GAAP.

                  II.11    No  Material  Adverse  Change;   Ordinary  Course  of
                           -----------------------------------------------------
Business. Except as set forth in Schedule 2.11 hereto or the SEC Documents or as
- --------                         -------------
previously  disclosed to the Purchasers in writing, (i) since December 31, 1998,
there has not been any  material  adverse  change in the  Condition  of  Integra
(other than the incurrence of operating losses  consistent with historic results
of Integra) and (ii) since  December 31,  1998,  neither  Integra nor any of its
Subsidiaries  has  participated in any transaction or acted outside the ordinary
course of business.

<PAGE>

                                                             Page 40 of 83 Pages

                  II.12    SEC Documents.
                           -------------

                           (a)      Integra has filed all SEC Documents required
to be filed by it since  December  31,  1997  under  the  Securities  Act or the
Exchange Act, and all amendments thereto.

                           (b)      As of its  filing  date,  each SEC  Document
(including  all exhibits and  schedules  thereto and documents  incorporated  by
reference therein), in each case as amended, referred to in subsection (a) above
(i) complied in all material  respects with the applicable  requirements  of the
Exchange Act and (ii) did not contain any untrue statement of a material fact or
omit to state any material fact necessary in order to make the  statements  made
therein,  in  light  of the  circumstances  under  which  they  were  made,  not
misleading.  Integra  is not aware of any issues  raised  by, or  correspondence
(other than routine filing packages and cover letters) with, the Commission with
respect to any of the SEC Documents.

                  II.13    Investment  Company.  Integra  is not an  "investment
                           -------------------
company" within the meaning of the Investment Company Act of 1940, as amended.

                  II.14    Private Offering.  No form of general solicitation or
                           ----------------
general  advertising  was used by Integra or its  representatives  in connection
with the offer or sale of the Purchased Shares or the Warrants.  No registration
of the  Purchased  Shares or the  Warrants,  pursuant to the  provisions  of the
Securities  Act or any state  securities  or "blue sky" laws, is required on the
date  hereof  or on the  Closing  Date by the  offer,  sale or  issuance  of the
Securities.  Integra  hereby  agrees  that  neither it nor anyone  acting on its
behalf,  will offer to sell the  Purchased  Shares or the  Warrants or any other
security  so as to  require  the  registration  of the  Purchased  Shares or the
Warrants,  pursuant  to the  provisions  of  the  Securities  Act  or any  state
securities or "blue sky" laws, unless such securities are so registered.

                  II.15    Employee  Benefit Plans.  All employee  benefit plans
                           -----------------------
(as defined in Section 3(3) of ERISA) or  arrangements  of Integra or any of the
Subsidiaries are in substantial  compliance with all applicable  Requirements of
Law.  The  execution  and  delivery  of this  Agreement  and  each of the  other
Transaction  Documents,  the purchase and sale of the Purchased Shares hereunder
and the  consummation of the transactions  contemplated  hereby and thereby will
not result in any  prohibited  transaction  within the meaning of Section 406 of
ERISA or  Section  4975 of the Code,  assuming  that  none of the  consideration
received by Integra pursuant to this Agreement is derived from the assets of any
employee benefit plan.

<PAGE>

                                                             Page 41 of 83 Pages

                  II.16    Title to  Assets.  Except  as set  forth in  Schedule
                           ----------------                             --------
2.16,  each of  Integra  and  its  Subsidiaries  has  good  title  to all of its
- ----
properties  and assets used in the business  described in the SEC  Documents and
reflected as owned on the  Financial  Statements or so described in any Schedule
hereto,  in each  case  free  and  clear  of any  Lien,  except  for  (a)  Liens
specifically  described on the notes to the Financial  Statements  and (b) Liens
not material to the Condition of Integra.

                  II.17    Intellectual Property.
                           ---------------------

                           (a)      Schedule   2.17(a)  sets  forth  all  United
                                    ------------------
States and foreign patents and patent  applications,  trademark and service mark
registrations  and  applications,  and copyright  registrations and applications
owned or licensed by Integra and all material licenses,  sublicenses,  and other
agreements or permissions  ("IP Licenses")  under which Integra is a licensor or
licensee or otherwise is authorized to use or practice any Intellectual Property
(as defined below).

                           (b)      Except  as set  forth in  Schedule  2.17(b),
                                                              -----------------
Integra  owns or  otherwise  has the right to use,  and will  continue to own or
otherwise  have the right to use  immediately  following  the Closing,  free and
clear of any and all  Encumbrances,  all United  States and foreign  patents and
patent applications,  trademark and service mark registrations and applications,
copyright registrations and applications, trade secrets, know-how, software, and
other technology and proprietary rights (collectively,  "Intellectual Property")
used in the operation of its business as described in the SEC Documents.

                           (c)      Except as set forth on Schedule 2.17(c),  to
                                                           ----------------
the best of Integra's knowledge,  Integra's use or licensing of the Intellectual
Property used in the operation of its business as described in the SEC Documents
does not infringe or otherwise  violate any Intellectual  Property rights of any
third party.  Except as set forth on Schedule 2.17(c),  no litigation is pending
                                     ----------------
and no  claim  has been  made in  writing  against  Integra  or,  to the best of
Integra's  knowledge,  is threatened  contesting the right of Integra to sell or
license to third  parties or use the  Intellectual  Property  presently  sold or
licensed to third parties or used by Integra.

                           (d)      Integra has taken all reasonable precautions
to protect the secrecy, confidentiality,  and value of its trade secrets and the
proprietary  nature and value of its know-how,  patents,  and other  technology.
Each  employee  and  third  party  who has  contributed  to the  development  of
Intellectual  Property on behalf of Integra has signed an agreement with Integra
stating that such employee or third party (i) shall maintain the confidentiality
of Integra's trade secrets and other confidential information,  and (ii) assigns
to Integra  all rights  that such  employee  or third  party  might have in such
Intellectual  Property,  except where the terms of particular agreements provide
otherwise.  To the  knowledge  of Integra,  no such  employee or third party has
materially breached any such agreement.

                  II.18    Trade  Relations.  Except  as set  forth in  Schedule
                           ----------------                             --------
2.18,  there  exists  no  actual  or  threatened  termination,  cancellation  or
- ----
limitation  of,  or  any  adverse   modification  or  change  in,  the  business
relationship  of Integra or any of its  Subsidiaries  with,  any customer or any
group of customers whose purchases are individually or in the aggregate material
to the  business  of Integra or any of its  Subsidiaries,  or with any  material
supplier,   and  there  exists  no  present   condition  or  state  of  fact  or
circumstances that would materially adversely affect the Condition of Integra or
prevent  Integra from  conducting  its business  after the  consummation  of the
transactions  contemplated  by this Agreement and each of the other  Transaction
Documents,  in  substantially  the  same  manner  in  which  such  business  has
heretofore been conducted and described in the SEC Documents.

<PAGE>

                                                             Page 42 of 83 Pages

                  II.19    Contracts   and   Other   Agreements.   All   of  the
                           ------------------------------------
Contractual  Obligations  of  Integra  and  any of  its  Subsidiaries  that  are
currently in effect and are required to be described in the SEC  Documents or to
be filed as exhibits  thereto are (a) described in the SEC Documents or filed as
exhibits thereto and (b) valid, subsisting, in full force and effect and binding
upon Integra or its  Subsidiaries,  as the case may be, and, to the knowledge of
Integra,  the other parties thereto,  in accordance with their terms.  Except as
set forth on Schedule  2.19,  Integra  has paid in full or accrued all  material
             --------------
amounts  currently due  thereunder and has satisfied in full or provided for all
of its currently matured liabilities and obligations  thereunder,  and is not in
default  under  any of them.  Except  as set  forth  on  Schedule  2.19,  to the
                                                         --------------
knowledge of Integra,  no other party to any such  Contractual  Obligation is in
breach thereof or in default  thereunder nor does any condition  exist that with
notice or lapse of time or both will  constitute  a breach  thereof  or  default
thereunder by such other party,  except for such breaches or defaults that would
not have a material adverse effect on the Condition of Integra.

                  II.20    Liabilities. As at December 31, 1998, neither Integra
                           -----------
nor any of its Subsidiaries  had any direct or indirect  obligation or liability
required by GAAP to be set forth on its  financial  statements  or the footnotes
thereto  (the  "Liabilities")  that were not fully and  adequately  reflected or
reserved against in the Financial Statements.

                  II.21    Broker's,  Finder's  or  Similar  Fees.  There are no
                           --------------------------------------
brokerage  commissions,  finder's fees or similar fees or commissions payable by
Integra in connection  with the  transactions  contemplated  hereby based on any
agreement,  arrangement or understanding with Integra or any of its Subsidiaries
or any action taken by any such entity.

<PAGE>

                                                             Page 43 of 83 Pages

                  II.22    Disclosure;   Agreement  and  Other  Documents.  This
                           ----------------------------------------------
Agreement,  each of the other Transaction Documents and each of the certificates
furnished to the Purchasers by Integra in connection  with the purchase and sale
of the Purchased Shares and the Warrants at or prior to the Closing,  taken as a
whole, do not contain any untrue statement of a material fact or omit to state a
material  fact  necessary in order to make the  statements  contained  herein or
therein,  in the light of the  circumstances  under  which they were  made,  not
misleading.

                  II.23    NeuroCare   Acquisition   Agreement.    Integra   has
                           -----------------------------------
delivered  to  the  Purchasers  a  true  and  complete  copy  of  the  NeuroCare
Acquisition Agreement,  and all of the representations and warranties of Integra
as set forth therein  shall be true and complete in all material  respects as of
the date hereof and as at the Closing Date.

SECTION III.      REPRESENTATIONS AND WARRANTIES
                  OF THE PURCHASERS
                  -----------------

                  Each  of  the  Purchasers   hereby   represents  and  warrants
(severally as to itself and not jointly) to Integra as follows:

                  III.1    Existence and Power. Such Purchaser that is an entity
                           -------------------
(a) is duly organized and validly existing under the laws of the jurisdiction of
its formation and (b) has the requisite power and authority to execute,  deliver
and  perform  its  obligations  under  this  Agreement  and  each  of the  other
Transaction Documents to which it is a party.

                  III.2    Authorization;   No  Contravention.   The  execution,
                           ----------------------------------
delivery and  performance  by such  Purchaser of this  Agreement and each of the
other  Transaction  Documents  to  which  it is a  party  and  the  transactions
contemplated hereby and thereby, including,  without limitation, the purchase of
the  Purchased  Shares and the  Warrants,  (a) have been duly  authorized by all
necessary  action,   (b)  do  not  contravene  the  terms  of  such  Purchaser's
organizational  documents,  or any  amendment  thereof,  and (c) do not violate,
conflict with or result in any breach or contravention of or the creation of any
Lien under, any Contractual Obligation of such Purchaser,  or any Requirement of
Law applicable to such Purchaser.

                  III.3    Governmental Authorization;  Third Party Consents. No
                           -------------------------------------------------
approval, consent, compliance, exemption,  authorization, or other action by, or
notice to, or filing with, any Governmental  Authority or any other Person,  and
no lapse of a  waiting  period  under a  Requirement  of Law,  is  necessary  or
required in connection with the execution,  delivery or performance  (including,
without  limitation,  the purchase of the Purchased Shares and the Warrants) by,
or  enforcement  against,  such Purchaser of this  Agreement,  each of the other
Transaction  Documents to which it is a party and the transactions  contemplated
hereby or thereby.

<PAGE>

                                                             Page 44 of 83 Pages

                  III.4    Binding Effect.  This Agreement and each of the other
                           --------------
Transaction  Documents  to which  it is a party  have  been  duly  executed  and
delivered  by such  Purchaser  and  constitute  the  legal,  valid  and  binding
obligations of such  Purchaser,  enforceable  against it in accordance  with its
terms,  except  as  enforceability  may be  limited  by  applicable  bankruptcy,
insolvency,  reorganization,  fraudulent  conveyance or transfer,  moratorium or
similar laws  affecting the  enforcement  of creditors'  rights  generally or by
equitable   principles   relating  to  enforceability   (regardless  of  whether
considered in a proceeding at law or in equity).

                  III.5    Purchase for Own Account.  The  Purchased  Shares and
                           ------------------------
the Warrants to be acquired by such  Purchaser  pursuant to this  Agreement  are
being  or will  be  acquired  for  its own  account  and  with no  intention  of
distributing  or  reselling  such  Purchased  Shares or any part  thereof in any
transaction  that would be in  violation  of the  securities  laws of the United
States of America,  or any state,  without prejudice,  however, to the rights of
such  Purchaser at all times to sell or otherwise  dispose of all or any part of
such  Purchased  Shares or Warrants  under an effective  registration  statement
under the Securities Act, or under an exemption from such registration available
under the Securities Act, and subject,  nevertheless, to the disposition of such
Purchaser's  property  being at all times within its control.  If such Purchaser
should in the future decide to dispose of any of the Securities,  such Purchaser
understands  and agrees that it may do so only in compliance with the Securities
Act and  applicable  state  securities  laws, as then in effect.  Such Purchaser
agrees  to  the  imprinting,  so  long  as  required  by  law,  of a  legend  on
certificates representing the Securities substantially to the following effect:

         "THE  SECURITIES   REPRESENTED  BY  THIS   CERTIFICATE  HAVE  NOT  BEEN
         REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR
         THE  SECURITIES  LAWS OF ANY  STATE  AND  MAY NOT BE SOLD OR  OTHERWISE
         DISPOSED OF EXCEPT  PURSUANT  TO AN  EFFECTIVE  REGISTRATION  STATEMENT
         UNDER THE ACT AND APPLICABLE  STATE  SECURITIES  LAWS OR PURSUANT TO AN
         APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE ACT."

         "THE SECURITIES  REPRESENTED BY THIS CERTIFICATE MAY BE ENTITLED TO THE
         BENEFITS OF A REGISTRATION RIGHTS AGREEMENT AMONG INTEGRA  LIFESCIENCES
         CORPORATION  AND  THE  ORIGINAL   PURCHASERS  OF  THE  PREFERRED  STOCK
         REPRESENTED  HEREBY.  TRANSFEREES OF SUCH SECURITIES SHOULD REVIEW SUCH
         AGREEMENT TO DETERMINE THEIR RIGHTS."

<PAGE>

                                                             Page 45 of 83 Pages

                  III.6    Accreditation;  Sophistication; Other Securities Laws
                           -----------------------------------------------------
Matters.  Each Purchaser (a) is an "accredited  investor"  within the meaning of
- -------
Rule 501 under the Securities  Act; (b) has sufficient  knowledge and experience
in investing  in  companies  similar to Integra so as to be able to evaluate the
risks and merits of its  investment in Integra and is able  financially  to bear
the risks thereof;  (c) has had an opportunity  to discuss  Integra's  business,
management  and  financial  affairs  with  Integra's  management;  and  (d) is a
resident  of the  jurisdiction  listed next to its name on Schedule 1 hereto for
                                                           ----------
purposes of state "blue sky" securities law purposes.

                  III.7    Broker's,  Finder's  or  Similar  Fees.  There are no
                           --------------------------------------
brokerage  commissions,  finder's fees or similar fees or commissions payable by
the Purchasers or any of them, in connection with the transactions  contemplated
hereby based on any agreement,  arrangement or understanding with such Purchaser
or any action taken by such Purchaser.

SECTION IV.       CONDITIONS TO THE OBLIGATION
                  OF THE PURCHASERS TO CLOSE
                  --------------------------

                  The  obligation  of the  Purchasers  to purchase the Purchased
Shares and the Warrants,  to pay the purchase  price therefor at the Closing and
to perform any  obligations  hereunder  shall be subject to the  satisfaction as
determined  by, or waiver by, the  Purchasers of the following  conditions on or
before the Closing Date.

                  IV.1     Representations  and Warranties.  The representations
                           -------------------------------
and  warranties  of Integra  contained  in  Section II hereof  shall be true and
correct in all material respects at and on the Closing Date as if made at and on
such date, except to the extent that any  representation  and warranty expressly
speaks as of an earlier date, in which case such  representation and warranty is
true and correct as of such date and except for any  activities or  transactions
which may have taken place after the date hereof which are  contemplated by this
Agreement.

                  IV.2     Compliance  with this  Agreement.  Integra shall have
                           --------------------------------
performed and complied in all material  respects with all of its  agreements and
conditions  set forth herein that are required to be performed or complied  with
by Integra on or before the Closing Date.

                  IV.3     Secretary's  Certificate.  The Purchasers  shall have
                           ------------------------
received a certificate from Integra,  in form and substance  satisfactory to the
Purchasers,  dated the Closing  Date and signed by a secretary  or an  assistant
secretary of Integra, certifying (a) that the attached copies of the Certificate
of  Incorporation,  the By-laws and  resolutions  of the Board of  Directors  of
Integra approving this Agreement,  each of the other  Transaction  Documents and
the transactions  contemplated  hereby and thereby,  are all true,  complete and
correct and remain  unamended  and in full force and  effect,  and (b) as to the
incumbency  and specimen  signature of each  officer of Integra  executing  this
Agreement,  each of the  other  Transaction  Documents  and any  other  document
delivered in connection herewith on behalf of Integra.

<PAGE>

                                                             Page 46 of 83 Pages

                  IV.4     Officers'  Certificate.  The  Purchasers  shall  have
                           ----------------------
received a certificate from Integra,  in form and substance  satisfactory to the
Purchasers,  dated the  Closing  Date and signed by  Integra's  chief  executive
officer  and  its  treasurer,   certifying  that  (a)  the  representations  and
warranties of Integra contained in Section II hereof are true and correct in all
material respects on the Closing Date and (b) Integra has performed and complied
with in all material  respects all of the agreements and conditions set forth or
contemplated  herein that are  required  to be  performed  or  complied  with by
Integra on or before the Closing Date.

                  IV.5     Documents.  The Purchasers  shall have received true,
                           ---------
complete and correct copies of such documents as they may reasonably  request in
connection  with or relating to the issue and sale of the  Purchased  Shares and
the  transactions  contemplated  hereby,  all in form and  substance  reasonably
satisfactory to the Purchasers.

                  IV.6     Filing of Certificate of Designation. The Certificate
                           ------------------------------------
of Designation shall have been duly filed by Integra with the Secretary of State
of the State of Delaware in accordance  with the General  Corporation Law of the
State of Delaware.

                  IV.7     Registration  Rights  Agreement.  Integra  shall have
                           -------------------------------
duly executed and delivered the Registration Rights Agreement,  substantially in
the form attached hereto as Exhibit C.
                            ---------

                  IV.8     Opinion  of  Counsel.   The  Purchasers   shall  have
                           --------------------
received an opinion of counsel to Integra,  dated the Closing Date,  relating to
the transactions contemplated hereby or referred to herein, substantially in the
form attached hereto as Exhibit D.
                        ---------

                  IV.9     Approval  of Counsel to the  Purchasers.  All actions
                           ---------------------------------------
and proceedings  hereunder and all documents required to be delivered by Integra
hereunder  or  in  connection  with  the   consummation   of  the   transactions
contemplated  hereby, and all other related matters,  shall have been acceptable
to Paul, Weiss, Rifkind, Wharton & Garrison, counsel to the Purchasers, in their
reasonable judgment as to their form and substance.

                  IV.10    Purchased  Shares.  Integra  shall have  delivered to
                           -----------------
each of the Purchasers  stock  certificates in definitive form  representing the
number of Purchased  Shares set forth opposite such Purchaser's name on Schedule
                                                                        --------
1 hereto and registered in the name of such Purchaser.
- -

<PAGE>

                                                             Page 47 of 83 Pages

                  IV.11    Warrants.   Integra  shall  have  duly  executed  and
                           --------
delivered  to the  Purchasers  the  Warrants,  each  substantially  in the  form
attached hereto as Exhibit A.
                   ---------

                  IV.12    Consents and  Approvals.  All  consents,  exemptions,
                           -----------------------
authorizations,  or other actions by, or notices to, or filings with (other than
the  filings  referenced  in  Section  2.3(a)  and  (d)  hereof),   Governmental
Authorities  and other  Persons in respect of all  Requirements  of Law and with
respect to those  Contractual  Obligations  of Integra  which are  necessary  or
required in connection with the execution,  delivery or performance  (including,
without limitation,  the issuance of the Purchased Shares, the Warrants,  shares
of Common  Stock  issuable  upon  conversion  of the  Purchased  Shares  and the
exercise of the Warrants) by, or enforcement against,  Integra of this Agreement
and each of the other  Transaction  Documents shall have been obtained and be in
full force and effect, and each of the Purchasers shall have been furnished with
appropriate evidence thereof.

                  IV.13    No Litigation. No action, suit, proceeding,  claim or
                           -------------
dispute  shall  have been  brought or  otherwise  arisen at law,  in equity,  in
arbitration or before any Governmental  Authority  against Integra or any of its
Subsidiaries which would, if adversely  determined,  (a) have a material adverse
effect on the Condition of Integra or (b) have a material  adverse effect on the
ability of Integra to perform its obligations under this Agreement or any of the
other Transaction Documents.

                  IV.14    No Material Judgment or Order.  There shall not be on
                           -----------------------------
the Closing Date any Order of a court of competent jurisdiction or any ruling of
any Governmental Authority or any condition imposed under any Requirement of Law
which would, in the judgment of the Purchasers, (a) prohibit or restrict (i) the
purchase of the Purchased  Shares or (ii) the  consummation of the  transactions
contemplated  by this  Agreement,  (b) subject the  Purchasers to any penalty or
other  onerous  condition  under or  pursuant to any  Requirement  of Law if the
Purchased Shares were to be purchased hereunder or (c) restrict the operation of
the  business of Integra or any of the  Subsidiaries  as  conducted  on the date
hereof in a manner that would have a material adverse effect on the Condition of
Integra.

                  IV.15    No Material  Adverse  Change.  Since the date hereof,
                           ----------------------------
there shall have been no material  adverse  change in the  Condition  of Integra
(other than operating losses consistent with the historic results of Integra).

                  IV.16    Neurocare  Acquisition.  All conditions  precedent to
                           ----------------------
the  consummation  of  the  Neurocare  Acquisition  Agreement  shall  have  been
satisfied in all material respects (and not waived,  except for any waiver which
would not be adverse to the Purchasers in any material respect).

<PAGE>

                                                             Page 48 of 83 Pages

SECTION V.        CONDITIONS TO THE OBLIGATION
                  OF THE COMPANY TO CLOSE
                  -----------------------
     
                  The  obligations  of Integra  to issue and sell the  Purchased
Shares and to perform its other obligations  hereunder,  shall be subject to the
satisfaction as determined by, or waiver by, Integra of the following conditions
on or before the Closing Date:

                  V.1      Representations  and Warranties.  The representations
                           -------------------------------
and warranties of the  Purchasers  contained in Section III hereof shall be true
and correct on at and on the Closing Date as if made at and on such date, except
to the extent that any  representation  and warranty  expressly  speaks as of an
earlier date, in which case such representation and warranty is true and correct
as of such date and except for any  activities  or  transactions  which may have
taken place after the date hereof which are contemplated by this Agreement.

                  V.2      Compliance with this Agreement.  The Purchasers shall
                           ------------------------------
have  performed  and  complied  in all  material  respects  with  all  of  their
agreements  and conditions set forth herein that are required to be performed or
complied with by the Purchasers on or before the Closing Date.

                  V.3      Registration  Rights Agreement.  The Purchasers shall
                           ------------------------------
have  duly   executed  and   delivered  the   Registration   Rights   Agreement,
substantially in the form attached hereto as Exhibit C.
                                             ---------

                  V.4      Consents and  Approvals.  All  consents,  exemptions,
                           -----------------------
authorizations,   or  other   actions  by,  or  notices  to,  or  filings  with,
Governmental Authorities and other Persons in respect of all Requirements of Law
and with respect to those  Contractual  Obligations of the Purchasers  which are
necessary or required in connection with the execution,  delivery or performance
(including,  without  limitation,  the  purchase of the  Purchased  Shares,  the
Warrants,  and the  shares of  Common  Stock  issuable  upon  conversion  of the
Purchased  Shares and the exercise of the Warrants) by, or enforcement  against,
the Purchasers of this  Agreement  shall have been obtained and be in full force
and effect,  and Integra shall have been  furnished  with  appropriate  evidence
thereof.

                  V.5      Payment  of  Purchase   Price.   Integra  shall  have
                           -----------------------------
received the aggregate purchase price for the Purchased Shares and the Warrants.

                 V.6       No Material Judgment or Order.  There shall not be on
                           -----------------------------
the Closing Date any Order of a court of competent jurisdiction or any ruling of
any Governmental Authority or any condition imposed under any Requirement of Law
which would,  in the judgment of Integra,  (a) prohibit or restrict (i) the sale
of the  Purchased  Shares  or the  Warrants  or  (ii)  the  consummation  of the
transactions  contemplated  by this  Agreement  or (b)  subject  Integra  to any
penalty or other onerous  condition  under or pursuant to any Requirement of Law
if the Purchased Shares were to be sold hereunder.

<PAGE>

                                                             Page 49 of 83 Pages

                  V.6      Opinion of Counsel.  Integra  will have  received the
                           ------------------
opinion of Paul, Weiss, Wharton & Garrison,  dated the Closing Date, relating to
the transactions contemplated hereby or referred to herein, substantially in the
form attached hereto as Exhibit E.
                        ---------

SECTION VI.       INDEMNIFICATION
                  ---------------

                  VI.1     Indemnification. Except as otherwise provided in this
                           ---------------
Section VI,  Integra  agrees to indemnify,  defend and hold harmless each of the
Purchasers  and their  Affiliates  and  their  respective  officers,  directors,
agents,  employees,  subsidiaries,  members,  partners and  controlling  persons
(each, an "Indemnified  Party") to the fullest extent  permitted by law from and
against any and all Losses (as hereinafter  defined) resulting from, arising out
of or  relating  to any  breach of any  representation,  warranty,  covenant  or
agreement  by  Integra in this  Agreement  or the other  Transaction  Documents,
including,  without limitation,  Losses arising out of or relating to any legal,
administrative or other actions  (including actions brought by the Purchasers or
Integra or any equity  holders of Integra or derivative  actions  brought by any
Person claiming  through or in Integra's  name),  proceedings or  investigations
(whether formal or informal),  or written threats thereof,  based upon, relating
to or arising out of this Agreement,  each of the other  Transaction  Documents,
the transactions  contemplated  hereby and thereby,  or any Indemnified  Party's
role  therein  or in  transactions  contemplated  hereby or  thereby;  provided,
                                                                       --------
however,  that the  Integra  shall not be liable  under this  Section  6.1 to an
- -------
Indemnified  Party to the extent that it is finally  judicially  determined that
such Losses  resulted  primarily  from the material  breach by such  Indemnified
Party of any  representation,  warranty,  covenant  or other  agreement  of such
Indemnified Party contained in this Agreement;  and provided,  further,  that if
                                                    --------   -------
and to the extent that such  indemnification  is  unenforceable  for any reason,
then Integra shall make the maximum contribution to the payment and satisfaction
of such Losses which shall be permissible  under applicable  laws.  Losses means
all losses,  claims  (including any claim by a third party),  damages,  expenses
(including reasonable fees,  disbursements and other charges of counsel incurred
by the Indemnified Party in any action between Integra and the Indemnified Party
or between  the  Indemnified  Party and any third party or  otherwise)  or other
liabilities;  provided,  however,  that  Losses  shall  include  only (a) direct
              --------   -------
out-of-pocket  payments of judgments and settlements,  costs and expenses of the
Indemnified Parties and (b) diminution in value of the Purchased Shares directly
attributable to a breach of any representation,  warranty, covenant or agreement
by Integra in this Agreement or the other Transaction Documents.

<PAGE>

                                                             Page 50 of 83 Pages

                  VI.2     Notification.   Each  Indemnified  Party  under  this
Section VI will, promptly after the receipt of notice of the commencement of any
action, investigation,  claim or other proceeding against such Indemnified Party
in respect of which  indemnity may be sought from Integra under this Section VI,
notify  Integra in writing of the  commencement  thereof.  The  omission  of any
Indemnified  Party to so notify  Integra of any such  action  shall not  relieve
Integra from any liability which Integra may have to such Indemnified  Party (a)
other than pursuant to this Section VI or (b) under this Section VI unless,  and
only to the extent  that,  such  omission  results in  Integra's  forfeiture  of
substantive  rights  or  defenses.  In case  any  such  action,  claim  or other
proceeding  shall be brought against any  Indemnified  Party and it shall notify
Integra of the  commencement  thereof,  Integra  shall be entitled to assume the
defense  thereof  at  its  own  expense,   with  counsel  satisfactory  to  such
Indemnified  Party  in its  reasonable  judgment;  provided,  however,  that any
                                                   --------   -------
Indemnified  Party  may,  at  its  own  expense,   retain  separate  counsel  to
participate in such defense at its own expense.  Notwithstanding  the foregoing,
in any action,  claim or proceeding in which both Integra,  on the one hand, and
an  Indemnified  Party,  on the other  hand,  are, or are  reasonably  likely to
become, a party,  such Indemnified Party shall have the right to employ separate
counsel at the expense of Integra and to control its own defense of such action,
claim or proceeding if, in the reasonable opinion of counsel to such Indemnified
Party, a conflict or potential conflict exists between Integra, on the one hand,
and such  Indemnified  Party,  on the other hand,  that would make such separate
representation  advisable;  provided,  however, that Integra shall not be liable
                            --------   -------
for the fees and expenses of more than one counsel to all  Indemnified  Parties.
Integra  agrees  that it will not,  without  the prior  written  consent  of the
Purchasers,  settle,  compromise  or consent to the entry of any judgment in any
pending or  threatened  claim,  action or  proceeding  relating  to the  matters
contemplated  hereby (if any  Indemnified  Party is a party  thereto or has been
actually  threatened  to be  made  a  party  thereto)  unless  such  settlement,
compromise or consent  includes an  unconditional  release of the Purchasers and
each other Indemnified Party from all liability arising or that may arise out of
such  claim,   action  or  proceeding  and  imposes  no  obligations  upon  such
Indemnified Party.  Integra shall not be liable for any settlement of any claim,
action or proceeding  effected against an Indemnified  Party without its written
consent,  which consent shall not be unreasonably  withheld. The rights accorded
to  each  Indemnified  Party  hereunder  shall  be the  sole  rights  that  such
Indemnified  Party may have at common law, by separate  agreement or  otherwise;
provided,  however,  that  notwithstanding  the  foregoing  or  anything  to the
- --------   -------
contrary contained in this Agreement,  nothing in this Section VI shall restrict
or limit  any  rights  that any  Indemnified  Party  may have to seek  equitable
relief.

<PAGE>

                                                             Page 51 of 83 Pages

                  VI.3     Registration   Rights   Agreement.    Notwithstanding
                           ---------------------------------
anything to the contrary contained in this Section VI, the  indemnification  and
contribution  provisions of the  Registration  Rights Agreement shall govern any
claim made with respect to  registration  statements  filed pursuant  thereto or
sales made thereunder.

SECTION VII.      AFFIRMATIVE COVENANTS
                  ---------------------

                  Integra hereby  covenants and agrees with the Purchasers  with
respect to this Section VII so long as any shares of Preferred Stock,  shares of
Common Stock issuable upon the conversion  thereof,  the Warrants or the Warrant
Shares are outstanding,  except to the extent that a particular  section of this
Section VII provides for an earlier termination as follows:

                  VII.1    Preservation of Existence. From the date hereof until
                           -------------------------
the Closing  Date,  Integra  shall,  and shall use its best efforts to cause its
Subsidiaries to:

                           (a)      preserve  and  maintain  in full  force  and
effect its  existence and good standing  under the laws of its  jurisdiction  of
formation or organization;

                           (b)      take all  reasonable  action to preserve and
maintain   in  full   force  and  effect  all   material   rights,   privileges,
qualifications,  applications,  estimates,  licenses and franchises necessary in
the normal conduct of its business;

                           (c)      use its  reasonable  efforts to preserve its
business organization;

                           (d)      conduct  its  business  in  accordance  with
sound  business  practices and keep its useful and necessary  properties in good
working order and condition (normal wear and tear excepted);

                           (e)      comply with all Requirements of Law and with
the directions of any Governmental Authority having jurisdiction over Integra or
any of the Subsidiaries or their  respective  business or property except to the
extent that the failure to comply with any  Requirements of Law would not have a
material adverse effect on the Condition of Integra; and

                           (f)      file or cause to be filed in a timely manner
all reports,  applications,  estimates  and licenses that shall be required by a
Governmental  Authority  and that,  if not timely  filed,  would have a material
adverse effect on the Condition of Integra.

<PAGE>

                                                             Page 52 of 83 Pages

                  VII.2    Delivery of 1998 Audited Financial Statements.
                           ---------------------------------------------

                           (a)      Integra shall  deliver to the  Purchasers as
soon as available a true and correct copy of its audited consolidated  financial
statements   (balance  sheet  and  statement  of  operations,   cash  flows  and
shareholders equity,  together with the notes thereto) for the fiscal year ended
and as at December 31, 1998 (the "Audited  Financial  Statements") which will be
the same in all material respect as the Financial Statements.

                           (b)      In   the   event   the   Audited   Financial
Statements differ in any material respect from the Financial Statements, Integra
shall  indemnify the  Purchasers  for the reduction in the value of the Series B
Preferred  Stock, if any, caused by such differences by paying to the Purchasers
an amount in cash or shares of Common Stock equal to such reduction in value.

                  VII.3    Financial  Statements and Other Information.  Integra
                           -------------------------------------------
shall  deliver to the  Purchasers,  in form and  substance  satisfactory  to the
Purchasers:

                           (a)      as soon as  available,  but not  later  than
ninety (90) days after the end of each  fiscal  year of  Integra,  a copy of the
audited consolidated balance sheet of Integra and its Subsidiaries as of the end
of such year and the related  statements of  operations  and cash flows for such
fiscal year,  setting forth in each case in comparative form the figures for the
previous year, all in reasonable detail and accompanied by a management  summary
and analysis of the operations of Integra and its  Subsidiaries  for such fiscal
year and by the opinion of a nationally recognized  independent certified public
accounting  firm  which  report  shall  state  without  qualification  that such
consolidated  financial  statements present fairly the financial condition as of
such date and results of operations and cash flows for the periods  indicated in
conformity with GAAP applied on a consistent basis; provided,  however, that the
                                                    --------   -------
delivery to each of the Purchasers of a copy of Integra's  Annual Report on Form
10-K for each fiscal year shall satisfy the requirements of this Section 7.3(a);

                           (b)      commencing  with the fiscal period ending on
March 31, 1999, as soon as available, but in any event not later than forty-five
(45) days  after  the end of each of the first  three  fiscal  quarters  of each
fiscal  year,  the  unaudited  consolidated  balance  sheet of  Integra  and its
Subsidiaries,  and the related  statements of operations and cash flows for such
quarter  and for the period  commencing  on the first day of the fiscal year and
ending on the last day of such quarter,  all certified by an appropriate officer
of Integra as  presenting  fairly the  financial  condition  as of such date and
results of  operations  and cash flows for the periods  indicated in  conformity
with GAAP  applied  on a  consistent  basis,  subject to normal  year-end  audit
adjustments and the absence of footnotes  required by GAAP;  provided,  however,
                                                             --------   -------
that the delivery to each of the  Purchasers  of a copy of  Integra's  Quarterly
Report on Form 10-Q for each fiscal  quarter shall satisfy the  requirements  of
this Section 7.3(b);

<PAGE>

                                                             Page 53 of 83 Pages

                           (c)      at  any  time  when  it is  not  subject  to
Section  13 or 15(d) of the  Exchange  Act,  upon  request,  to the  Purchasers,
information  of the type  that  would  satisfy  the  requirement  of  subsection
(d)(4)(i) of Rule 144A (or any similar successor provision) under the Securities
Act; and

                           (d)      except as  otherwise  provided  in  Sections
7.3(a) and (b),  promptly after the same are filed,  copies of all  registration
statements,  proxy statements,  reports and other documents required to be filed
by Integra  under the  Securities  Act or the Exchange  Act, and all  amendments
thereto.

                  VII.4    Reservation  of  Shares.  Integra  shall at all times
                           -----------------------
reserve and keep available out of its authorized shares of Common Stock,  solely
for the purpose of issue or delivery upon conversion of the Purchased Shares, as
provided in the Certificate of Designation and the Certificate of Incorporation,
and the exercise of the Warrants,  the number of shares of Common Stock that may
be issuable or deliverable upon such conversion or exercise. Integra shall issue
such shares of Common Stock in accordance with the terms of this Agreement,  the
Certificate of Incorporation, the Certificate of Designation (in the case of the
shares of Common Stock issuable upon conversion of the Purchased Shares) and the
Warrants (in the case of the Warrant Shares),  as the case may be, and otherwise
comply with the terms hereof and thereof.

                  VII.5    Registration  and  Listing.  If any  shares of Common
                           --------------------------
Stock  required  to be reserved  for  purposes of  conversion  of the  Purchased
Shares,  as provided in the  Certificate  of  Designation or the exercise of the
Warrants, as provided in the Warrants,  require registration with or approval of
any  Governmental  Authority under any Federal or state or other  applicable law
before such shares of Common Stock may be issued or delivered upon conversion or
exercise, Integra will in good faith and as expeditiously as possible cause such
shares of Common Stock to be duly  registered  or approved,  as the case may be,
unless such  registration  or approval is required solely because of a breach of
the Purchasers'  representation  contained in Section 3.5. So long as the shares
of Common  Stock are quoted on the NASDAQ or listed on any  national  securities
exchange,  Integra  will,  if permitted by the rules of such system or exchange,
quote or list and keep  quoted  or  listed  on such  system  or  exchange,  upon
official notice of issuance,  all shares of Common Stock issuable or deliverable
upon conversion of the Preferred Shares and exercise of the Warrants.

                  VII.6    Board  Representation.  For so long as the Purchasers
                           ---------------------
or  Affiliates  thereof  collectively  own at least  one  half of their  initial
investment in the Series B Preferred  Stock or the Common Stock into which it is
converted,   the   Purchasers   as  a  group  shall  be  entitled  to  name  one
representative    to   Integra's   Board   of   Directors   (the    "Purchasers'
Representative"),   which   Purchasers'   Representative   shall  be  reasonably
satisfactory to the Chief  Executive  Officer of Integra and who initially shall
be Neal  Moszkowski.  Integra will use its best efforts to cause the Purchasers'
Representative  to be nominated  and to solicit  proxies for his  election.  The
Purchasers  as a group will also be entitled to  representation  on  significant
committees of Integra Board of Directors.

<PAGE>

                                                             Page 54 of 83 Pages

                  VII.7    Director  and Officer  Liability  Insurance.  Integra
                           -------------------------------------------
will maintain director and officer liability insurance  reasonably  satisfactory
to the Purchasers. 

SECTION VIII.     TERMINATION OF AGREEMENT
                  ------------------------

                  VIII.1   Termination.  This Agreement may be terminated  prior
                           -----------
to the Closing as follows:

                           (a)      at any time on or prior to the Closing Date,
by mutual written consent of Integra and the Purchasers; or

                           (b)      at the election of Integra or the Purchasers
by written  notice to the other  parties  hereto after 5:00 p.m.,  New York City
time on April 30, 1999, if the transactions contemplated by this Agreement shall
not have been consummated  pursuant hereto,  unless such date is extended by the
mutual written consent of Integra and the Purchasers; or

                           (c)      at the  election of  Integra,  if any one or
more of the conditions to its obligation to close set forth in Section V has not
been  satisfied  or  waived  and the  Closing  shall  not have  occurred  on the
scheduled Closing Date; or

                           (d)      at the  election of the  Purchasers,  if any
one or more of the conditions to its obligation to close set forth in Section IV
has not been  satisfied or waived and the Closing shall not have occurred on the
scheduled Closing Date; or

                           (e)      at the  election  of  Integra,  if there has
been a material breach of any representation, warranty, covenant or agreement on
the part of the  Purchasers  contained in this  Agreement,  which breach has not
been cured within ten (10)  Business  Days of notice to the  Purchasers  of such
breach; or

                           (f)      at the election of the Purchasers,  if there
has  been  a  material  breach  of any  representation,  warranty,  covenant  or
agreement on the part of Integra  contained in this Agreement,  which breach has
not been cured within ten (10) Business Days notice to Integra of such breach.

If this  Agreement  so  terminates,  it shall  become  null and void and have no
further force or effect, except as provided in Section 8.2.

<PAGE>

                                                             Page 55 of 83 Pages

                  VIII.2   Survival.  If this  Agreement is  terminated  and the
                           --------
transactions  contemplated  hereby are not consummated as described above,  this
Agreement  shall  become  void and of no  further  force and  effect;  provided,
                                                                       --------
however, that (i) none of the parties hereto shall have any liability in respect
- -------
of a termination of this Agreement  pursuant to Section 8.1(a) or Section 8.1(b)
and (ii) nothing shall  relieve any party from any liability for actual  damages
resulting  from a termination  of this  Agreement  pursuant to Section 8.1(e) or
8.1(f);  and provided  further,  that none of the parties  hereto shall have any
             --------  -------
liability for speculative,  indirect,  unforeseeable  or  consequential  damages
resulting from a termination of this Agreement pursuant to Section VIII.

SECTION IX.       MISCELLANEOUS
                  -------------

                  IX.1     Survival of  Representations  and Warranties.  Except
                           --------------------------------------------
for the  representations  and  warranties in Section 2.7(c) (which shall survive
without limitation), all of the representations and warranties made herein shall
survive the execution and delivery of this Agreement for a period ending 60 days
after the  delivery by Integra to the  Purchasers  of its  audited  consolidated
financial statements (balance sheet and statement of operations,  cash flows and
shareholders' equity,  together with the notes hereto) for the fiscal year ended
and as at December 31, 1999;  provided,  however,  that if Integra exercises its
Put Right during the Second Term the representations and warranties set forth in
the CEO Certificate shall survive for a period of one year following the receipt
by the Purchasers of the Additional Preferred Stock.

                  IX.2     Notices.    All    notices,    demands    and   other
                           -------
communications  provided for or permitted hereunder shall be made in writing and
shall be by registered or certified  first-class mail, return receipt requested,
telecopier, courier service, overnight mail or personal delivery:

                           (i)          if to Quantum Industrial Partners LDC.:

                                        Kaya Flamboyan 9,
                                        Villemstad
                                        Curacao
                                        Netherlands-Antilles

                                        with a copy to:

                                        Soros Fund Management LLC
                                        888 Seventh Avenue
                                        New York, NY 10016
                                        Telecopy:  (212) 664-0544
                                        Attn: Michael Neus, Esq.


<PAGE>

                                                             Page 56 of 83 Pages

                                        and a copy to:

                                        Paul, Weiss, Rifkind, Wharton & Garrison
                                        1285 Avenue of the Americas
                                        New York, New York 10019-6064
                                        Telecopy:      (212) 757-3990
                                        Attention:     Matthew Nimetz, Esq.

                           (ii)         If to SFM Domestic Investments LLC:

                                        Soros Fund Management LLC
                                        888 Seventh Avenue
                                        New York, NY 10016
                                        Telecopy:  (212) 664-0544
                                        Attn:      Michael Neus, Esq.

                                        with a copy to:

                                        Paul, Weiss, Rifkind, Wharton & Garrison
                                        1285 Avenue of the Americas
                                        New York, New York 10019-6064
                                        Telecopy:      (212) 757-3990
                                        Attention:     Matthew Nimetz, Esq.


                           (iii)        if to Integra:

                                        Integra LifeSciences Corporation
                                        105 Morgan Lane
                                        Plainsboro, NJ 08536
                                        Telecopy:      (609) 799-3297
                                        Attention:     Stuart M. Essig,
                                                       President and CEO

                                        with a copy to:

                                        Drinker Biddle & Reath LLP
                                        105 College Road East
                                        Princeton, NJ 08542-0627
                                        Telecopy:     (609) 799-7000
                                        Attention:    John E. Stoddard III, Esq.
<PAGE>

                                                             Page 57 of 83 Pages

                                           

                  All such  notices and  communications  shall be deemed to have
been duly given when delivered by hand, if personally delivered;  when delivered
by courier or overnight  mail,  if delivered by  commercial  courier  service or
overnight  mail;  five (5)  Business  Days after  being  deposited  in the mail,
postage prepaid,  if mailed; and when receipt is mechanically  acknowledged,  if
telecopied.

                  IX.3     Successors and Assigns. This Agreement shall inure to
                           ----------------------
the benefit of and be binding upon the successors  and permitted  assigns of the
parties hereto.  Subject to applicable  securities  laws, each of the Purchasers
may assign any of its rights  under  this  Agreement  to any of its  Affiliates.
Integra may not assign any of its rights  under this  Agreement  and each of the
other  Transaction  Documents,  except to a  successor-in-interest  to  Integra,
without  the  written  consent of all of the  Purchasers.  Except as provided in
Section VI no Person  other than the  parties  hereto and their  successors  and
permitted  assigns is intended to be a beneficiary of this Agreement and each of
the other Transaction Documents.

                  IX.4     Amendment and Waiver.
                           --------------------

                           (a)      No  failure  or delay on the part of Integra
or the  Purchasers  in exercising  any right,  power or remedy  hereunder  shall
operate as a waiver  thereof,  nor shall any single or partial  exercise  of any
such right,  power or remedy preclude any other or further  exercise  thereof or
the exercise of any other right, power or remedy.

                           (b)      Any amendment, supplement or modification of
or to any  provision  of this  Agreement,  any waiver of any  provision  of this
Agreement,  and any consent to any departure by Integra or the  Purchasers  from
the terms of any provision of this Agreement,  shall be effective (i) only if it
is made or given in writing and signed by Integra and the  Purchasers,  and (ii)
only in the specific  instance  and for the  specific  purpose for which made or
given. Except where notice is specifically required by this Agreement, no notice
to or  demand on  Integra  in any case  shall  entitle  Integra  to any other or
further notice or demand in similar or other circumstances.

                  IX.5     Counterparts.  This  Agreement may be executed in any
                           ------------
number of counterparts and by the parties hereto in separate counterparts,  each
of which when so  executed  shall be deemed to be an  original  and all of which
taken together shall constitute one and the same agreement.

                  IX.6     Headings.  The  headings  in this  Agreement  are for
                           --------
convenience  of  reference  only and  shall not limit or  otherwise  affect  the
meaning hereof.

<PAGE>

                                                             Page 58 of 83 Pages

                  IX.7     GOVERNING  LAW. THIS  AGREEMENT  SHALL BE GOVERNED BY
                           --------------
AND  CONSTRUED IN ACCORDANCE  WITH THE LAWS OF THE STATE OF NEW JERSEY,  WITHOUT
REGARD TO THE PRINCIPLES OF CONFLICTS OF LAW THEREOF.

                  IX.8     Severability.  If any one or  more of the  provisions
                           ------------
contained  herein,  or the  application  thereof  in any  circumstance,  is held
invalid,  illegal or unenforceable in any respect for any reason,  the validity,
legality and  enforceability of any such provision in every other respect and of
the remaining  provisions  hereof shall not be in any way  impaired,  unless the
provisions held invalid, illegal or unenforceable shall substantially impair the
benefits of the remaining provisions hereof.

                  IX.9     Rules of Construction.  Unless the context  otherwise
                           ---------------------
requires, "or" is not exclusive, and references to sections or subsections refer
to sections or subsections of this Agreement.

                  IX.10    Entire Agreement.  This Agreement,  together with the
                           ----------------
exhibits and schedules hereto, and the other Transaction  Documents are intended
by the parties as a final  expression  of their  agreement  and intended to be a
complete and  exclusive  statement of the  agreement  and  understanding  of the
parties  hereto in respect of the subject matter  contained  herein and therein.
There are no  restrictions,  promises,  warranties or  undertakings,  other than
those set forth or referred to herein or therein.

                  IX.11    Fees.  Upon the Closing,  Integra shall reimburse the
                           ----
Purchasers for their reasonable  out-of-pocket  expenses  (including  attorney's
fees,   disbursements  and  other  charges)  incurred  in  connection  with  the
transactions  contemplated by this Agreement;  provided,  however,  that Integra
                                               --------   -------
shall  not  be  obligated  to  reimburse  the   Purchasers  for  any  reasonable
out-of-pocket expenses in excess of $40,000 in the aggregate.

                  IX.12    Publicity; Confidentiality.
                           --------------------------

                           (a)      Except as may be required by applicable  law
or the rules of any  securities  exchange  or  market on which  shares of Common
Stock are traded,  none of the parties hereto shall issue a publicity release or
public announcement or otherwise make any disclosure  concerning this Agreement,
the transactions  contemplated  hereby or the business and financial  affairs of
Integra, without prior approval by the other parties hereto; provided,  however,
                                                             --------   -------
that nothing in this  Agreement  shall  restrict any Purchaser  from  disclosing
information (i) that is already publicly available,  (ii) that was known to such
Purchaser on a non-confidential  basis prior to its disclosure by Integra, (iii)
that may be required or appropriate in response to any summons or subpoena or in
connection with any litigation, provided that such Purchaser will use reasonable
                                --------


<PAGE>

                                                             Page 59 of 83 Pages

efforts to notify Integra in advance of such  disclosure so as to permit Integra
to seek a  protective  order or  otherwise  contest  such  disclosure,  and such
Purchaser will use reasonable  efforts to cooperate,  at the expense of Integra,
with Integra in pursuing any such protective order, (iv) to the extent that such
Purchaser  reasonably believes it appropriate in order to protect its investment
in the Purchased  Shares in order to comply with any  Requirement of Law, (v) to
such Purchaser's officers,  directors,  agents,  employees,  members,  partners,
controlling  persons,  auditors or  counsel,  (vi) to Persons who are parties to
similar  confidentiality  agreements or (vii) to the  prospective  transferee in
connection  with any  contemplated  transfer  of any of the  Securities.  If any
announcement  is  required  by law or the rules of any  securities  exchange  or
market  on which  shares  of  Common  Stock  are  traded to be made by any party
hereto,  prior to making such  announcement  such party will  deliver a draft of
such  announcement  to the  other  parties  and  shall  give the  other  parties
reasonable opportunity to comment thereon.

                           (b)      The Purchasers shall have the opportunity to
review and modify any provision of any publicly  release or public  announcement
or document  which is to be released to the public or filed with the SEC,  which
provision mentions Soros Fund Management LLC or any of its Affiliates,  prior to
the release of such  document to the public or the filing of such  document with
the SEC.  

                  IX.13    Further Assurances. Each of the parties shall execute
                           ------------------
such  documents and perform such further acts  (including,  without  limitation,
obtaining  any  consents,  exemptions,  authorizations  or other  actions by, or
giving any notices to, or making any filings with, any Governmental Authority or
any other Person) as may be reasonably  required or desirable to carry out or to
perform the provisions of this Agreement.

                  IX.14    Schedules.   Anything   disclosed   on  any  schedule
                           ---------
attached hereto shall be deemed disclosed on all schedules attached hereto.


<PAGE>

                                                             Page 60 of 83 Pages



                  IN WITNESS  WHEREOF,  the  parties  hereto  have  caused  this
Agreement to be executed and  delivered by their  respective  officers  hereunto
duly authorized on the date first above written.


                                  INTEGRA LIFESCIENCES CORPORATION


                                  By:   /S/ STUART M. ESSIG
                                        ________________________________________
                                        Name:      Stuart M. Essig
                                        Title:     President and Chief Executive
                                                   Officer


                                  QUANTUM INDUSTRIAL PARTNERS LDC


                                  By:   /S/ MICHAEL C. NEUS
                                        ________________________________________
                                        Name:  Michael C. Neus
                                        Title: Attorney-in-Fact


                                  SFM DOMESTIC INVESTMENTS LLC


                                  By:   /S/ MICHAEL C. NEUS
                                        ________________________________________
                                        Name:  Michael C. Neus    
                                        Title:     


<PAGE>
       
                                                             Page 61 of 83 Pages

                                                                      Schedule 1
                                                                      ----------

                PURCHASED SHARES AND WARRANTS AND PURCHASE PRICE
                ------------------------------------------------
<TABLE>
<CAPTION>


<S>                                              <C>                                <C>                           <C>    

         Purchaser                                    Shares of                        Warrants                   Purchase Price
                                                 Series B Preferred                    Purchased
                                                 Stock Purchased From               From the Company
                                                     the Company    


Quantum Industrial Partners LDC                      75,000                           180,000                        $7,500,000
(principal place of business: Curacao)

SFM Domestic Investments LLC                         25,000                            60,000                        $2,500,000
(principal place of business: New
York)

</TABLE>





                                                             Page 62 of 83 Pages

________________________________________________________________________________




                          REGISTRATION RIGHTS AGREEMENT


                                      among


                        INTEGRA LIFESCIENCES CORPORATION,


                        QUANTUM INDUSTRIAL PARTNERS LDC,


                                       and


                          SFM DOMESTIC INVESTMENTS LLC






              _____________________________________________________


                              Dated: March 29, 1999

              _____________________________________________________






________________________________________________________________________________





<PAGE>

<TABLE>
<CAPTION>

                                                             Page 63 of 83 Pages


                                TABLE OF CONTENTS


<S>      <C>                                                                                             <C>    
                                                                                                       Page
                                                                                                       ----
1.       Definitions.....................................................................................1

2.       General; Securities Subject to this Agreement...................................................3
         (a)      Grant of Rights........................................................................3
         (b)      Registrable Securities.................................................................3
         (c)      Holders of Registrable Securities......................................................4

3.       Demand Registration.............................................................................4
         (a)      Request for Demand Registration........................................................4
         (b)      Effective Demand Registration..........................................................4
         (c)      Expenses...............................................................................5
         (d)      Underwriting Procedures................................................................5
         (e)      Selection of Underwriters..............................................................5

4.       Piggy-Back Registration.........................................................................6
         (a)      Piggy-Back Rights......................................................................6
         (b)      Expenses...............................................................................7

5.       Holdback Agreements.............................................................................7
         (a)      Restrictions on Public Sale by Designated Holders......................................7
         (b)      Restrictions on Public Sale by the Company.............................................7

6.       Registration Procedures.........................................................................8
         (a)      Obligations of the Company.............................................................8
         (b)      Obligations of Each Designated Holder of Registrable Securities.......................11
         (c)      Notice to Discontinue.................................................................12
         (d)      Registration Expenses.................................................................12

7.       Indemnification; Contribution..................................................................13
         (a)      Indemnification by the Company........................................................13
         (b)      Indemnification by Designated Holders.................................................13
         (c)      Conduct of Indemnification Proceedings................................................14
         (d)      Contribution..........................................................................14

8.       Rule 144.......................................................................................15





<PAGE>

                                                                                       Page 64 of 83 Pages



9.       Miscellaneous..................................................................................15
         (a)      Recapitalizations, Exchanges, etc.....................................................15
         (b)      No Inconsistent Agreements............................................................16
         (c)      Remedies..............................................................................16
         (d)      Amendments and Waivers................................................................16
         (e)      Notices...............................................................................16
         (f)      Successors and Assigns; Third Party Beneficiaries.....................................18
         (g)      Counterparts..........................................................................18
         (h)      Headings..............................................................................18
         (i)      GOVERNING LAW.........................................................................18
         (j)      Severability..........................................................................18
         (k)      Entire Agreement......................................................................18
         (l)      Further Assurances....................................................................19

</TABLE>

<PAGE>

                                                             Page 65 of 83 Pages

                          REGISTRATION RIGHTS AGREEMENT


                  REGISTRATION  RIGHTS  AGREEMENT,  dated  March 29,  1999 (this
"Agreement"),  among INTEGRA  LIFESCIENCES  CORPORATION,  a Delaware corporation
 ---------
(the  "Company"),  QUANTUM  INDUSTRIAL  PARTNERS LDC, a Cayman  Islands  limited
       -------
duration company ("QIP"),  and SFM DOMESTIC  INVESTMENTS LLC, a Delaware limited
liability company ("SFM DI" and together with QIP, the "Stockholders").

                  WHEREAS,  this Agreement is made in connection with the Series
B Convertible  Preferred Stock and Warrant Purchase  Agreement,  dated March 29,
1999 (the "Series B Agreement"), among the Company and the Stockholders pursuant
           ------------------
to which the Company has agreed to issue and sell to the  Stockholders,  and the
Stockholders  have agreed to purchase  from the  Company,  (i) an  aggregate  of
100,000 shares of Series B Preferred Stock and (ii) warrants (the "Warrants") to
                                                                   --------
purchase,  subject to the terms and conditions  thereof, an aggregate of 240,000
shares of Common Stock;

                  WHEREAS, in order to induce the Stockholders to purchase their
shares of Series B Preferred  Stock and the  Warrants,  the parties  hereto have
agreed to enter into this Agreement  pursuant to which the Company has agreed to
grant  registration  rights  with  respect  to the  Registrable  Securities  (as
hereinafter defined).

                  NOW,  THEREFORE,  in consideration of the mutual covenants and
agreements set forth herein and for good and valuable consideration, the receipt
and  adequacy  of which is hereby  acknowledged,  the  parties  hereto  agree as
follows:

                  1.     Definitions.  As used in this  Agreement  the following
                         -----------
terms have the meanings indicated:

                  "Act" means the Securities Act of 1933, as amended.
                   ---

                  "Affiliate"  shall mean any Person  who is an  "affiliate"  as
                   ---------
defined in Rule 12b-2 of the General  Rules and  Regulations  under the Exchange
Act, and any Person  controlling,  controlled  by, or under common  control with
Soros  Fund  Management  LLC.  For the  purposes  of this  Agreement,  "control"
includes the ability to have investment  discretion through contractual means or
by operation of law.

                  "Approved  Underwriter"  has the meaning assigned such term in
                   ---------------------
Section 3(e).

                  "Common  Stock"  means the  Common  Stock,  par value $.01 per
                   -------------
share,  of the Company or any other equity  securities of the Company into which
such securities are converted, reclassified, reconstituted or exchanged.



<PAGE>

                                                             Page 66 of 83 Pages


                  "Company  Underwriter"  has the meaning  assigned such term in
                   --------------------
Section 4(a).

                  "Demand  Registration"  has the meaning  assigned such term in
                   --------------------
Section 3(a).

                  "Designated  Holder" means each of the  Stockholders,  and any
                   ------------------
transferee of any of them to whom  Registrable  Securities have been transferred
in accordance with the provisions of this Agreement,  other than a transferee to
whom such securities have been transferred pursuant to a registration  statement
under the Securities Act or Rule 144 or Regulation S under the Securities Act.

                  "Exchange Act" means the  Securities  Exchange Act of 1934, as
                   ------------
amended, and the rules and regulations promulgated thereunder.

                  "Existing Rightholders" means the stockholders of the Company,
                   ---------------------
if any, who have obtained registration rights pursuant to agreements existing on
the date hereof.

                  "Initiating  Holders"  has the meaning  assigned  such term in
                   -------------------
Section 3(a).

                  "Inspector"  has the  meaning  assigned  such term in  Section
                   ---------
6(a)(viii).

                  "NASD"  has  the  meaning   assigned   such  term  in  Section
                   ----
6(a)(xiv).

                  "Person" means any individual, firm, corporation, partnership,
                   ------
trust,  incorporated or unincorporated  association,  joint venture, joint stock
company,  limited  liability  company,  government  (or an agency  or  political
subdivision  thereof)  or other  entity  of any  kind,  and  shall  include  any
successor (by merger or otherwise) of such entity.

                  "QIP" means Quantum Industrial Partners LDC.
                   ---

                  "Registrable  Securities" means each of the following: (a) any
                   -----------------------
shares of Common Stock owned by the  Designated  Holders issued or issuable upon
conversion of shares of Series B Preferred  Stock or Additional  Preferred Stock
(as defined in the Series B Agreement),  or upon  exercise of the Warrants,  (b)
any shares of Common  Stock  issued or  issuable by the Company to any or all of
the Designated  Holders during the time that any of such Designated  Holders are
holders of shares of Common Stock or shares of Series B Preferred Stock, (c) any
other shares of Common Stock acquired or owned by any of the Designated  Holders
and (d) any shares of Common Stock issued or issuable  with respect to shares of
Common  Stock and shares of Series B Preferred  Stock and  Additional  Preferred
Stock  by  way  of  stock  dividend  or  stock  split  or in  connection  with a
combination  of  shares,   recapitalization,   merger,  consolidation  or  other
reorganization or otherwise and shares of Common Stock issuable upon conversion,
exercise or exchange thereof.



<PAGE>

                                                             Page 67 of 83 Pages


                  "Registration  Expenses"  has the meaning set forth in Section
                   ----------------------
6(d).

                  "SEC" means the  Securities  and  Exchange  Commission  or any
                   ---
similar agency then having jurisdiction to enforce the Securities Act.

                  "Securities Act" means the Securities Act of 1933, as amended,
                   --------------
and the rules and regulations promulgated thereunder.

                  "Series B Agreement" has the meaning assigned such term in the
                   ------------------
recital to this Agreement.

                  "Series B Preferred  Stock" has the meaning assigned such term
                   -------------------------
in the recital to this Agreement.

                  "SFM DI" means SFM Domestic Investments LLC.
                   ------

                  "Stockholders"  means Quantum Industrial  Partners LDC and SFM
                   ------------
Domestic Investments LLC.

                  "Warrants"  has the meaning  assigned such term in the recital
                   --------
to this Agreement.

                  2.       General; Securities Subject to this Agreement.
                           ---------------------------------------------

                           (a)      Grant of Rights.  The Company  hereby grants
                                    ---------------
registration  rights to the Stockholders upon the terms and conditions set forth
in this Agreement.

                           (b)      Registrable Securities.  For the purposes of
                                    ----------------------
this  Agreement,  (i)  Registrable  Securities  will  cease  to  be  Registrable
Securities when a registration  statement  covering such Registrable  Securities
has  been  declared  effective  under  the  Securities  Act by the SEC and  such
Registrable  Securities  have  been  disposed  of  pursuant  to  such  effective
registration  statement and (ii) the securities of a Designated  Holder shall be
deemed  not to be  Registrable  Securities  at any  time  when  the  Company  is
registered  pursuant to Section 12 of the Exchange Act and the entire  amount of
such Designated Holder's Registrable  Securities proposed to be sold in a single
sale are or, in the  opinion  of counsel  satisfactory  to the  Company  and the
Designated Holder, each in their reasonable judgment,  may be distributed to the
public  pursuant to Rule 144 (or any successor  provision  then in effect) under
the Securities Act.

                           (c)      Holders of Registrable Securities.  A Person
                                    ---------------------------------
is deemed to be a holder of Registrable  Securities whenever such Person owns of
record  Registrable  Securities,  or holds an option to purchase,  or a security
convertible  into or exercisable or  exchangeable  for,  Registrable  Securities
whether or not such  acquisition  or  conversion  has actually been effected and


<PAGE>

                                                             Page 68 of 83 Pages


disregarding  any legal  restrictions  upon the exercise of such rights.  If the
Company receives conflicting instructions, notices or elections from two or more
Persons with  respect to the same  Registrable  Securities,  the Company may act
upon  the  basis of the  instructions,  notice  or  election  received  from the
registered owner of such Registrable Securities. Registrable Securities issuable
upon  exercise  of an option or upon  conversion  of another  security  shall be
deemed outstanding for the purposes of this Agreement.

                  3.       Demand Registration.
                           -------------------

                           (a)      Request for Demand Registration. At any time
                                    -------------------------------
on or after the date  hereof,  the  holders of more than 50% of the  Registrable
Securities  outstanding  may  make a  written  request  for  registration  (such
Designated Holders making such request being deemed to be "Initiating  Holders")
                                                           -------------------
of Registrable  Securities under the Securities Act, and under the securities or
"blue  sky" laws of a  reasonable  number of  jurisdictions  designated  by such
holder or holders (a "Demand Registration"); provided, however, that the Company
                      -------------------    --------  -------
shall not be required to effect more than two Demand  Registrations  pursuant to
this Section 3. If at the time of any request to register Registrable Securities
pursuant to this Section 3(a),  the Company is engaged in, or has fixed plans to
engage in within  ninety  (90) days of the time of such  request,  a  registered
public  offering or is engaged in any other  activity  which,  in the good faith
determination of the Board of Directors of the Company,  would be required to be
disclosed under applicable law as a result of such request or would be adversely
affected  by the  requested  registration,  then the  Company  may at its option
direct  that such  request be delayed for a  reasonable  period not in excess of
three  (3)  months  from  the  effective  date of such  offering  or the date of
completion  of such other  activity,  as the case may be,  such right to delay a
request  to be  exercised  by the  Company  not more than  once in any  one-year
period.  In  addition,   the  Company  shall  not  be  required  to  effect  any
registration  within  three (3)  months  after the  effective  date of any other
Registration   Statement  of  the  Company.  Each  such  request  for  a  Demand
Registration by the Initiating Holders shall state the amount of the Registrable
Securities  proposed to be sold, the intended method of disposition  thereof and
the jurisdictions in which registration is desired.  Upon a request for a Demand
Registration,  the Company  shall  promptly  take such steps as are necessary or
appropriate to prepare for the registration of the Registrable  Securities to be
registered.

                           (b)      Effective Demand  Registration.  The Company
                                    ------------------------------
shall use commercially  reasonable efforts to cause any such Demand Registration
to become  effective  not later than  forty-five  (45) days after it  receives a
request under Section 3(a) hereof and to remain  effective for the lesser of (i)
the period  during which all  Registrable  Securities  registered  in the Demand
Registration are sold and (ii) ninety (90) days; provided,  however, that if the
                                                 --------   -------
Initiating Holders request the Company to withdraw such  registration,  it shall
constitute a Demand  Registration unless the Initiating Holders promptly pay all
of the costs and  expenses  incurred  by the  Company  in  connection  with such
registration.



<PAGE>

                                                             Page 69 of 83 Pages


                           (c)      Expenses. In any registration initiated as a
                                    --------
Demand Registration, the Company shall pay all Registration Expenses (other than
underwriting discounts and commissions and brokerage commissions), including the
reasonable fees and expenses of one counsel  selected by the Designated  Holders
holding a  majority  of the  Registrable  Securities  being  registered  in such
registration  ("Holders'  Counsel")  in  connection  therewith  (not  to  exceed
                -----------------
$15,000), whether or not such Demand Registration becomes effective.

                           (d)      Underwriting  Procedures.  If the Initiating
                                    ------------------------
Holders  holding a majority  of the  Registrable  Securities  held by all of the
Initiating Holders to which the requested Demand Registration  relates so elect,
the offering of such Registrable Securities pursuant to such Demand Registration
shall be in the form of a firm commitment underwritten offering and the managing
underwriter  or  underwriters  selected for such offering  shall be the Approved
Underwriter (as hereinafter  defined)  selected in accordance with Section 3(e).
In such event, if the Approved  Underwriter  advises the Company in writing that
in its opinion the aggregate amount of such Registrable  Securities requested to
be included in such offering is  sufficiently  large to have a material  adverse
effect on the success of such  offering,  subject to the rights of the  Existing
Rightholders,  the Company shall include in such registration only the aggregate
amount of Registrable Securities that in the opinion of the Approved Underwriter
may be sold without any such material adverse effect and shall reduce,  first as
to the Company and any stockholders  who are not Designated  Holders as a group,
if any, and then as to the Designated  Holders as a group,  pro rata within each
group based on the number of Registrable  Securities included in the request for
Demand Registration, the amount of Registrable Securities to be included by each
Designated Holder in such registration.

                           (e)      Selection  of  Underwriters.  If any  Demand
                                    ---------------------------
Registration  of  Registrable  Securities  is in  the  form  of an  underwritten
offering,   the  Initiating  Holders  holding  a  majority  of  the  Registrable
Securities  held by all such  Initiating  Holders  shall  select  and  obtain an
investment  banking  firm  of  national   reputation  to  act  as  the  managing
underwriter of the offering (the  "Approved  Underwriter");  provided,  however,
                                   ---------------------     --------   -------
that the Approved  Underwriter  shall, in any case, be acceptable to the Company
in its reasonable judgment.

                  4.       Piggy-Back Registration.
                           -----------------------

                           (a)      Piggy-Back  Rights.  If the Company proposes
                                    ------------------
to file a  registration  statement  under the  Securities Act with respect to an
offering by the Company for its own account or for the account of an  Initiating
Holder pursuant to Section 3 of any class of security (other than a registration
statement on Form S-4 or S-8 or any successor forms  thereto),  then the Company
shall give  written  notice of such  proposed  filing to each of the  Designated
Holders of Registrable  Securities (other than any Initiating Holders), and such



<PAGE>

                                                             Page 70 of 83 Pages


notice shall describe in detail the proposed  registration  and distribution and
shall offer such  Designated  Holders  (other than any  Initiating  Holders) the
opportunity to register the number of Registrable Securities as each such holder
may request.  The Company shall, and shall use commercially  reasonable  efforts
(within ten (10) days of the notice  provided for in the preceding  sentence) to
cause the  managing  underwriter  or  underwriters  of a  proposed  underwritten
offering  (the  "Company  Underwriter")  to,  permit the  Designated  Holders of
                 --------------------
Registrable  Securities who have  requested in writing  (within ten (10) days of
the giving of the notice of the proposed  filing by the Company) to  participate
in the registration for such offering to include such Registrable  Securities in
such offering on the same terms and  conditions as the securities of the Company
included  therein.  In  connection  with any  offering  under this  Section 4(a)
involving  an  underwriting,  the  Company  shall not be required to include any
Registrable  Securities  in such  underwriting  unless (i) the  holders  thereof
accept the terms of the  underwriting as agreed upon between the Company and the
underwriters selected by it, (ii) if such underwriting has been initiated by the
Company or requested by another party that has contractual  registration rights,
all of the shares of Common  Stock held by the parties  making  such  request or
entitled to include  shares of Common  Stock  pursuant to the same rights as the
requesting  parties have been included in such registration and (iii) all of the
shares of Common Stock held by Existing Rightholders for which such registration
has been  requested by such  Existing  Rightholders  have been  included in such
registration, and then only in such quantity as will not, in the opinion of  the
underwriters,  jeopardize the success of the offering by the Company.  If in the
opinion of the Company  Underwriter  the  registration  of all, or part,  of the
Registrable  Securities  which  the  Designated  Holders  have  requested  to be
included would materially and adversely  affect such public  offering,  then the
Company  shall be  required to include in the  underwriting  only that number of
Registrable  Securities,  if any, which the Company Underwriter  believes may be
sold without  causing such adverse  effect,  and the amount of  securities to be
offered in the  underwriting  shall be allocated  first, to the Company based on
the number of shares it desires to sell in the underwritten offering for its own
account;  and  thereafter  pro rata among the  Initiating  Holders and all other
selling  stockholders,  if any, based on the number of shares otherwise proposed
to be  included  therein  by the  Initiating  Holders  and  such  other  selling
stockholders.  If the number of  Registrable  Securities  to be  included in the
underwriting  in accordance  with the foregoing is less than the total number of
shares which the Designated Holders of Registrable  Securities have requested to
be included,  then the  Designated  Holders of  Registrable  Securities who have
requested registration shall participate in the underwriting pro rata based upon
their total ownership of the Registrable  Securities.  If any Designated  Holder
would thus be entitled to include  more shares than such holder  requested to be
registered,  the excess shall be  allocated  among other  requesting  Designated
Holders pro rata based upon their total ownership of Registrable Securities.



<PAGE>

                                                             Page 71 of 83 Pages


                           (b)      Expenses.   The   Company   shall  bear  all
                                    --------
Registration  Expenses  (other than  underwriting  discounts and commissions and
brokerage  commissions),  including  the  reasonable  fees and  expenses  of the
Holders'  Counsel (not to exceed  $15,000),  in connection with any registration
pursuant to this Section 4.

                  5.       Holdback Agreements.
                           -------------------

                           (a)      Restrictions  on Public  Sale by  Designated
                                    --------------------------------------------
Holders.  Each Designated Holder of Registrable  Securities agrees not to effect
- -------
any public sale or distribution of any Registrable  Securities  being registered
or of any securities  convertible  into or  exchangeable or exercisable for such
Registrable  Securities,  including  a sale  pursuant  to  Rule  144  under  the
Securities  Act,  during the ninety (90) day period  beginning on the  effective
date of such registration  statement (except as part of such  registration),  if
and to the extent  requested  by the  Company in the case of a  non-underwritten
public offering or if and to the extent requested by the Company  Underwriter or
the Approved Underwriter in the case of an underwritten public offering,  except
to the extent that such  Designated  Holder is prohibited  by applicable  law or
exercise of fiduciary  duties from agreeing to withhold  Registrable  Securities
from sale or is acting in its capacity as a fiduciary or investment  adviser. If
requested by the Company  Underwriter,  each Designated  Holder will execute and
deliver a lock-up  agreement in a form  acceptable to such  Underwriter  and the
Company for purposes of its obligations  under this Section 5. Without  limiting
the scope of the term  "fiduciary,"  a  Designated  Holder shall be deemed to be
acting as a fiduciary or an investment adviser if its actions or the Registrable
Securities  proposed to be sold are subject to the  Employee  Retirement  Income
Security Act of 1974,  as amended,  or the  Investment  Company Act of 1940,  as
amended, or if such Registrable  Securities are held in a separate account under
applicable insurance law or regulation.

                           (b)      Restrictions  on Public Sale by the Company.
                                    -------------------------------------------
The Company agrees not to effect any public sale or  distribution  of any of its
securities  for  its  own  account,  or  any  securities   convertible  into  or
exchangeable   or  exercisable   for  such   securities   (except   pursuant  to
registrations  on Form S-4 or S-8 or any successor  forms  thereto),  during the
period  beginning on the effective date of any Demand  Registration in which the
Designated Holders of Registrable Securities are participating and ending on the
earlier of (i) the date on which all shares of Common Stock  registered  on such
registration  statement  are sold and (ii) the date  thirty  (30) days after the
effective date of such registration statement.

                  6.       Registration Procedures.
                           -----------------------

                           (a)      Obligations   of   the   Company.   Whenever
                                    --------------------------------
registration of Registrable  Securities has been requested pursuant to Section 3
or 4 of this Agreement, the Company shall use commercially reasonable efforts to
effect the registration  and sale of such  Registrable  Securities in accordance
with the  intended  method of  distribution  thereof as promptly  as  reasonably
practicable,  and in connection  with any such request,  the Company  shall,  as
promptly as reasonably possible:



<PAGE>

                                                             Page 72 of 83 Pages

                                    (i) use commercially  reasonable  efforts to
prepare and file with the SEC a registration statement on any form for which the
Company then  qualifies or which counsel for the Company shall deem  appropriate
and which form shall be available for the sale of such Registrable Securities in
accordance  with  the  intended  method  of   distribution   thereof,   and  use
commercially  reasonable efforts to cause such registration  statement to become
effective; provided, however, that (x) before filing a registration statement or
           --------  -------
prospectus or any amendments or supplements  thereto,  the Company shall provide
Holders'  Counsel  and any other  Inspector  (as  hereinafter  defined)  with an
adequate and  appropriate  opportunity to participate in the preparation of such
registration  statement and each prospectus included therein (and each amendment
or  supplement  thereto)  to be filed  with the SEC,  which  documents  shall be
subject to the review of Holders' Counsel,  and (y) the Company shall notify the
Holders'  Counsel and each seller of  Registrable  Securities  of any stop order
issued or  threatened  by the SEC and take all  reasonable  action  required  to
prevent the entry of such stop order or to remove it if entered;

                                    (ii)  prepare  and  file  with  the SEC such
amendments  and  supplements to such  registration  statement and the prospectus
used in  connection  therewith  as may be  necessary  to keep such  registration
statement  effective for the lesser of (x) ninety (90) days and (y) such shorter
period which will  terminate  when all  Registrable  Securities  covered by such
registration  statement  have been sold,  and comply with the  provisions of the
Securities Act with respect to the disposition of all securities covered by such
registration  statement  during  such  period in  accordance  with the  intended
methods of  disposition  by the sellers  thereof set forth in such  registration
statement;

                                    (iii) as  soon   as   reasonably   possible,
furnish to each seller of Registrable Securities, prior to filing a registration
statement, copies of such registration statement as is proposed to be filed, and
thereafter such number of copies of such registration statement,  each amendment
and  supplement  thereto (in each case  including  all  exhibits  thereto),  the
prospectus included in such registration  statement  (including each preliminary
prospectus) and such other documents as each such seller may reasonably  request
in order to facilitate the  disposition of the Registrable  Securities  owned by
such seller;

                                    (iv) use its best  efforts  to  register  or
qualify such  Registrable  Securities  under such other securities or "blue sky"
laws  of  such  jurisdictions  as  any  seller  of  Registrable  Securities  may
reasonably  request,  and to  continue  such  qualification  in  effect  in such
jurisdiction  for  as  long  as  permissible   pursuant  to  the  laws  of  such
jurisdiction,  or for as long as any such  seller  requests or until all of such
Registrable Securities are sold, whichever is shortest, and do any and all other
acts and things  which may be  reasonably  necessary  or advisable to enable any



<PAGE>

                                                             Page 73 of 83 Pages


such  seller  to  consummate  the  disposition  in  such  jurisdictions  of  the
Registrable Securities owned by such seller; provided, however, that the Company
                                             --------  -------
shall  not  be  required  to  (x)  qualify  generally  to  do  business  in  any
jurisdiction  where it would not  otherwise  be required to qualify but for this
Section 6(a)(iv), (y) subject itself to taxation in any such jurisdiction or (z)
consent to general service of process in any such jurisdiction;

                                    (v)  use  its  best  efforts  to  cause  the
Registrable  Securities covered by such registration  statement to be registered
with or approved by such other  governmental  agencies or  authorities as may be
necessary by virtue of the business and  operations of the Company to enable the
seller or sellers of  Registrable  Securities to consummate  the  disposition of
such Registrable Securities;

                                    (vi)  notify  each  seller  of   Registrable
Securities,  at any time when a  prospectus  relating  thereto is required to be
delivered  under the Securities  Act, upon discovery that, or upon the happening
of any event as a result of which, the prospectus  included in such registration
statement  contains an untrue statement of a material fact or omits to state any
material fact required to be stated  therein or necessary to make the statements
therein not misleading in light of the circumstances under which they were made,
and the  Company  shall  promptly  prepare a  supplement  or  amendment  to such
prospectus  (except that the Company may avoid  supplementing  or amending  such
prospectus for up to 90 days when, in the good faith  determination of the Board
of Directors of the Company,  supplementing  or amending such  prospectus  would
require  disclosure under  applicable law of any material  activity in which the
Company is then  engaged,  the  disclosure of which would  adversely  affect the
Company)  and  furnish  to each  seller  a  reasonable  number  of  copies  of a
supplement  to or an amendment of such  prospectus  as may be necessary so that,
after delivery to the purchasers of such Registrable Securities, such prospectus
shall not contain an untrue  statement  of a material  fact or omit to state any
material fact required to be stated  therein or necessary to make the statements
therein not misleading in light of the circumstances under which they were made;

                                    (vii)  enter  into  and  perform   customary
agreements  (including  an  underwriting  agreement in  customary  form with the
Approved  Underwriter or Company  Underwriter,  if any,  selected as provided in
Sections  3 or 4) and take such  other  actions as are  prudent  and  reasonably
required in order to expedite or facilitate the disposition of such  Registrable
Securities;

                                    (viii) make  available for inspection by any
seller of Registrable Securities,  any managing underwriter participating in any
disposition  pursuant to such registration  statement,  Holders' Counsel and any
attorney,  accountant or other agent retained by any such seller or any managing
underwriter  (each,  an "Inspector" and  collectively,  the  "Inspectors"),  all
                         ---------                            ----------



<PAGE>


                                                             Page 74 of 83 Pages

financial and other records, pertinent corporate documents and properties of the
Company  and  its  subsidiaries  (collectively,   the  "Records")  as  shall  be
reasonably   necessary   to  enable  them  to  exercise   their  due   diligence
responsibility,   and  cause  the  Company's  and  its  subsidiaries'  officers,
directors and employees,  and the independent public accountants of the Company,
to  supply  all  information  reasonably  requested  by any  such  Inspector  in
connection  with  such   registration   statement.   Records  that  the  Company
determines,  in good  faith,  to be  confidential  and  which  it  notifies  the
Inspectors are confidential  shall not be disclosed by the Inspectors unless (x)
the  disclosure of such Records is necessary to avoid or correct a  misstatement
or omission in the  registration  statement,  (y) the release of such Records is
ordered  pursuant  to a  subpoena  or  other  order  from a court  of  competent
jurisdiction  or is requested by any  regulatory  body  (including  the National
Association of Insurance  Commissioners)  or (z) the information in such Records
was known to the Inspectors on a non-confidential  basis prior to its disclosure
by the Company or has been made generally  available to the public.  Each seller
of Registrable Securities agrees that it shall, upon learning that disclosure of
such Records is sought in a court of competent jurisdiction,  give notice to the
Company  and  allow  the  Company,   at  the  Company's  expense,  to  undertake
appropriate action to prevent disclosure of the Records deemed confidential;

                                    (ix)  if  such  sale  is   pursuant   to  an
underwritten  offering,  use its best efforts to obtain a "cold comfort"  letter
from the Company's independent public accountants in customary form and covering
such  matters  of the type  customarily  covered  by "cold  comfort"  letters as
Holders'  Counsel or the  managing  underwriter  reasonably  request;  provided,
                                                                       --------
however, that the Company shall not be required to obtain such a letter from its
- -------
former independent public accountants;

                                    (x) use its best efforts to furnish,  at the
request of any seller of Registrable  Securities on the date such securities are
delivered to the underwriters for sale pursuant to such registration or, if such
securities are not being sold through underwriters, on the date the registration
statement with respect to such securities becomes effective,  an opinion,  dated
such  date,  of  counsel  representing  the  Company  for the  purposes  of such
registration,  addressed to the  underwriters,  if any, and to the seller making
such request,  covering such legal matters with respect to the  registration  in
respect  of which  such  opinion is being  given as such  seller may  reasonably
request and are customarily included in such opinions;

                                    (xi)  otherwise  use  its  best  efforts  to
comply with all applicable  rules and regulations of the SEC, and make available
to its security  holders,  as soon as reasonably  practicable  but no later than
fifteen (15) months after the effective date of the registration  statement,  an
earnings  statement  covering a period of twelve (12) months beginning after the
effective date of the  registration  statement,  in a manner which satisfies the
provisions of Section 11(a) of the Securities Act and Rule 158 thereunder;



<PAGE>

                                                             Page 75 of 83 Pages


                                    (xii) cause all such Registrable  Securities
to be listed on each securities  exchange on which similar  securities issued by
the Company are then listed,  provided, that the applicable listing requirements
are satisfied;

                                    (xiii)  keep  Holders'  Counsel  advised  in
writing as to the initiation of any registration  under Section 3 or 4 hereunder
and provide  Holders'  Counsel with copies of any SEC filings made in connection
therewith;

                                    (xiv)   cooperate   with   each   seller  of
Registrable Securities and each underwriter  participating in the disposition of
such Registrable  Securities and their respective counsel in connection with any
filings required to be made with the National Association of Securities Dealers,
Inc. (the "NASD"); and
           ----

                                    (xv) use commercially  reasonable efforts to
take all other steps  necessary to effect the  registration  of the  Registrable
Securities contemplated hereby.

                           (b)      Obligations  of Each  Designated  Holder  of
                                    --------------------------------------------
Registrable  Securities.  Following  the  filing  of  a  registration  statement
- -----------------------
registering  the Eligible  Securities  of any  Designated  Holder and during any
period that the registration statement is effective, each such Designated Holder
shall:

                                    (i)  not     effect    any     stabilization
transactions  or engage in any  stabilization  activity in  connection  with any
securities of the Company in  contravention of Regulation M under the Securities
Exchange Act of 1934, as amended (the "Exchange Act");

                                    (ii) furnish  each broker or dealer  through
whom such Designated Holder offers Eligible  Securities such number of copies of
the  prospectus  as the  broker  may  require  and  otherwise  comply  with  the
prospectus delivery requirements under the Securities Act;

                                    (iii)report to the Company  each  month  all
sales and other  dispositions  of Eligible  Securities  made by such  Designated
Holder during said month;

                                    (iv) not,   and   shall   not   permit   any
Affiliated Purchaser (as that term is defined in Regulation M under the Exchange
Act) to, bid for or purchase for any account in which such Designated Holder has
a beneficial  interest,  or attempt to induce any other person to purchase,  any
securities  of the Company in  contravention  of Regulation M under the Exchange
Act;



<PAGE>

                                                             Page 76 of 83 Pages


                                    (v) not offer or agree to pay,  directly  or
indirectly,  to anyone any compensation for soliciting  another to purchase,  or
for  purchasing  (other than for such  Designated  Holder's  own  account),  any
securities of the Company on a national  securities exchange in contravention of
Regulation M under the Exchange Act;

                                    (vi)  cooperate in all  reasonable  respects
with the Company as it fulfills  its  obligations  under this  Agreement;  (vii)
furnish such information  concerning such Designated Holder and the distribution
of the Eligible  Securities  as the Company may from time to time request to the
extent required by federal securities laws; and

                                    (viii) sell Eligible  Securities only in the
manner  described in the  Registration  Statement  or as otherwise  permitted by
federal securities laws.

                           (c)      Notice  to   Discontinue.   Each  Designated
                                    ------------------------
Holder of Registrable  Securities  agrees that,  upon receipt of any notice from
the  Company  of the  happening  of any event of the kind  described  in Section
6(a)(vi),  such  Designated  Holder shall forthwith  discontinue  disposition of
Registrable  Securities  pursuant to the  registration  statement  covering such
Registrable  Securities until such Designated  Holder's receipt of the copies of
the supplemented or amended prospectus  contemplated by Section 6(a)(vi). If the
Company  shall give any such notice,  the Company shall extend the period during
which such registration statement shall be maintained effective pursuant to this
Agreement  (including,  without  limitation,  the period  referred to in Section
6(a)(ii)) by the number of days during the period from and including the date of
the giving of such notice pursuant to Section 6(a)(vi) to and including the date
when the Designated Holder shall have received the copies of the supplemented or
amended  prospectus  contemplated  by and  meeting the  requirements  of Section
6(a)(vi).

                           (d)      Registration Expenses. The Company shall pay
                                    ---------------------
all expenses (other than as set forth in Sections 3(c) and 4(b)) arising from or
incident to the performance of, or compliance  with, this Agreement,  including,
without  limitation,  (i) SEC, stock exchange and NASD  registration  and filing
fees, (ii) all fees and expenses  incurred in complying with securities or "blue
sky" laws (including  reasonable  fees,  charges and  disbursements  of Holders'
Counsel  in  connection  with  "blue  sky"  qualifications  of  the  Registrable
Securities), (iii) all printing, messenger and delivery expenses, (iv) the fees,
charges  and  disbursements  of counsel to the  Company  and of its  independent
public accountants and any other accounting and legal fees, charges and expenses
incurred by the Company  (including,  without  limitation,  any expenses arising
from  any  special  audits  incident  to or  required  by  any  registration  or
qualification)  and (v) any liability  insurance or other premiums for insurance
obtained in connection with any Demand  Registration or piggy-back  registration
pursuant to the terms of this Agreement, regardless of whether such registration
statement is declared effective; provided, however, that, in connection with the
                                 --------  -------
registration or qualification of the Eligible  Securities under state securities
laws, nothing herein shall be deemed to require the Company to make any payments
to third  parties in order to obtain  "lock-up,"  escrow or other  extraordinary
agreements.  All of the  expenses  described  in this  Section 7 are referred to
herein as "Registration Expenses."
           ---------------------


<PAGE>

                                                             Page 77 of 83 Pages


                  7.       Indemnification; Contribution.
                           -----------------------------

                           (a)      Indemnification by the Company.  The Company
                                    ------------------------------
agrees to indemnify and hold harmless,  to the fullest extent  permitted by law,
each Designated Holder, its officers, directors,  trustees, partners, employees,
advisors  and agents and each  Person who  controls  (within  the meaning of the
Securities Act or the Exchange Act) such Designated  Holder from and against any
and all losses, claims, damages,  liabilities and expenses (including reasonable
costs of  investigation)  caused by any  untrue  statement  of a  material  fact
contained in any registration statement,  prospectus or notification or offering
circular (as amended or  supplemented  if the Company  shall have  furnished any
amendments or supplements thereto) or caused by any omission or alleged omission
to state therein a material  fact required to be stated  therein or necessary to
make  the  statements  therein  (in the  case of a  prospectus,  in light of the
circumstances under which they were made) not misleading,  except insofar as the
same are caused by or contained in any  information  concerning  such Designated
Holder  furnished in writing to the Company by such Designated  Holder expressly
for use therein or caused by such Designated  Holder's failure to deliver a copy
of the prospectus or any amendments or  supplements  thereto in accordance  with
the  requirements  of the  Securities  Act after the Company has furnished  such
Designated  Holder  with a copy of the same.  The  Company  shall  also  provide
customary indemnities to any underwriters of the Registrable  Securities,  their
officers, directors and employees and each Person who controls such underwriters
(within  the meaning of the  Securities  Act and the  Exchange  Act) to the same
extent as provided above with respect to the  indemnification  of the Designated
Holders of Registrable Securities.

                           (b)      Indemnification  by Designated  Holders.  In
                                    ---------------------------------------
connection  with any  registration  statement  in which a  Designated  Holder is
participating  pursuant to Section 3 or 4 hereof,  each such  Designated  Holder
shall  furnish to the Company in writing such  information  with respect to such
Designated Holder as the Company may reasonably request or as may be required by
law for use in connection with any such registration statement or prospectus and
each  Designated  Holder agrees to indemnify and hold  harmless,  to the fullest
extent  permitted by law, the Company,  any underwriter  retained by the Company
and their respective directors, officers, employees and each Person who controls
the Company or such  underwriter  (within the meaning of the  Securities Act and
the Exchange Act) to the same extent as the foregoing indemnity from the Company
to the Designated Holders, but only with respect to any such information with



<PAGE>

                                                             Page 78 of 83 Pages


respect to such  Designated  Holder  furnished in writing to the Company by such
Designated Holder expressly for use therein,  or with respect to such Designated
Holder's  failure  to  deliver a copy of the  prospectus  or any  amendments  or
supplements  thereto in accordance  with the  requirements of the Securities Act
after the Company has furnished such Designated  Holder with a copy of the same;
provided,  however,  that the total amount to be indemnified by such  Designated
- --------   -------
Holder  pursuant  to this  Section  7(b) shall be  limited  to the net  proceeds
received by such  Designated  Holder in the  offering to which the  registration
statement or prospectus relates. 

                           (c)      Conduct of Indemnification  Proceedings. Any
                                    ---------------------------------------
Person entitled to indemnification hereunder (the "Indemnified Party") agrees to
                                                   -----------------
give prompt written notice to the indemnifying party (the "Indemnifying  Party")
                                                           -------------------
after  the  receipt  by the  Indemnified  Party  of any  written  notice  of the
commencement of any action, suit,  proceeding or investigation or threat thereof
made in writing for which the Indemnified Party intends to claim indemnification
or contribution pursuant to this Agreement;  provided, however, that the failure
                                             --------  -------
so to notify the Indemnifying  Party shall not relieve the Indemnifying Party of
any liability that it may have to the Indemnified  Party hereunder except to the
extent that the delay or failure to give such notice  materially  prejudices the
ability  of  the  Indemnifying  Party  to  defend  such  action.  If  notice  of
commencement  of any such  action  is given to the  Indemnifying  Party as above
provided, the Indemnifying Party shall be entitled to participate in and, to the
extent  it may  wish,  jointly  with  any  other  Indemnifying  Party  similarly
notified,  to assume the defense of such action at its own expense, with counsel
chosen by it and satisfactory to such Indemnified  Party. The Indemnified  Party
shall  have  the  right to  employ  separate  counsel  in any  such  action  and
participate  in the defense  thereof,  but the fees and expenses of such counsel
shall be paid by the Indemnified Party unless (i) the Indemnifying  Party agrees
to pay the same, (ii) the Indemnifying Party fails to assume the defense of such
action with counsel  satisfactory  to the  Indemnified  Party in its  reasonable
judgment or (iii) the named parties to any such action  (including any impleaded
parties)  have  been  advised  by  such  counsel  that  representation  of  such
Indemnified  Party  and the  Indemnifying  Party  by the same  counsel  would be
inappropriate under applicable standards of professional  conduct, in which case
the  Indemnifying  Party  shall not have the right to assume the defense of such
action on behalf of such  Indemnified  Party.  No  Indemnifying  Party  shall be
liable for any  settlement  entered  into  without  its written  consent,  which
consent shall not be unreasonably withheld.

                           (d)      Contribution.    If   the    indemnification
                                    ------------
provided for in this Section 7 from the Indemnifying  Party is unavailable to an
Indemnified  Party  hereunder  in  respect  of  any  losses,  claims,   damages,
liabilities or expenses  referred to therein,  then the  Indemnifying  Party, in
lieu of indemnifying such Indemnified Party, shall contribute to the amount paid
or  payable  by such  Indemnified  Party as a  result  of such  losses,  claims,
damages, liabilities or expenses in such proportion as is appropriate to reflect
the relative fault of the Indemnifying Party and Indemnified Party in connection
with the actions which resulted in such losses, claims, damages,  liabilities or
expenses, as well as any other relevant equitable  considerations.  The relative
faults of such  Indemnifying  Party and Indemnified Party shall be determined by



<PAGE>

                                                             Page 79 of 83 Pages


reference to, among other things, whether any action in question,  including any
untrue or alleged  untrue  statement  of a material  fact or omission or alleged
omission to state a material  fact,  has been made by, or relates to information
supplied by, such  Indemnifying  Party or  Indemnified  Party,  and the parties'
relative intent, knowledge,  access to information and opportunity to correct or
prevent  such  action.  The amount paid or payable by a party as a result of the
losses,  claims,  damages,  liabilities and expenses  referred to above shall be
deemed to include,  subject to the  limitations set forth in Sections 7(a), 7(b)
and 7(c), any  reasonable  legal or other fees,  charges or expenses  reasonably
incurred  by such party in  connection  with any  investigation  or  proceeding;
provided that the total amount to be indemnified by such Designated Holder shall
- --------
be  limited  to the net  proceeds  received  by such  Designated  Holder  in the
offering.

                  The  parties  hereto  agree  that it  would  not be  just  and
equitable if  contribution  pursuant to this Section 7(d) were determined by pro
rata allocation or by any other method of allocation which does not take account
of  the  equitable  considerations  referred  to in  the  immediately  preceding
paragraph. No person guilty of fraudulent  misrepresentation (within the meaning
of Section 11(f) of the Securities Act) shall be entitled to  contribution  from
any person.

                  8.       Rule 144.
                           --------

                  The Company  covenants that it shall file any reports required
to be filed by it under the  Exchange  Act;  and that it shall take such further
action  as each  Designated  Holder of  Registrable  Securities  may  reasonably
request (including providing any information  necessary to comply with Rules 144
and 144A under the Securities Act), all to the extent required from time to time
to  enable  such  Designated  Holder  to  sell  Registrable  Securities  without
registration  under the  Securities  Act within the limitation of the exemptions
provided by (a) Rule 144 under the Securities  Act, as such rules may be amended
from time to time, or (b) any similar rules or regulations  hereafter adopted by
the SEC.  The  Company  shall,  upon the  request  of any  Designated  Holder of
Registrable Securities, deliver to such Designated Holder a written statement as
to whether it has complied with such requirements.

                  9.       Miscellaneous.

                           (a)      Recapitalizations,   Exchanges,   etc.   The
                                    -------------------------------------
provisions of this Agreement  shall apply,  to the full extent set forth herein,
with  respect to (i) the  shares of Common  Stock and (ii) to any and all equity
securities of the Company or any successor or assign of the Company  (whether by
merger,  consolidation,  sale of  assets  or  otherwise)  which may be issued in
respect of, in conversion of, in exchange for or in substitution  of, the shares
of Common Stock and shall be  appropriately  adjusted  for any stock  dividends,
splits, reverse splits,  combinations,  recapitalizations and the like occurring
after the date hereof.



<PAGE>

                                                             Page 80 of 83 Pages


                           (b)      No  Inconsistent  Agreements.   The  Company
                                    ----------------------------
shall not enter  into any  agreement  with  respect  to its  securities  that is
inconsistent with the rights granted to the Designated Holders in this Agreement
or grant any additional registration rights to any Person or with respect to any
securities  which are not Registrable  Securities which are prior in right to or
inconsistent with the rights granted in this Agreement.

                           (c)      Remedies.   The   Designated   Holders,   in
                                    --------
addition  to being  entitled to exercise  all rights  granted by law,  including
recovery of damages,  shall be entitled to specific  performance of their rights
under this  Agreement.  The Company  agrees that  monetary  damages would not be
adequate  compensation  for any loss incurred by reason of a breach by it of the
provisions  of this  Agreement  and  hereby  agrees to waive in any  action  for
specific performance the defense that a remedy at law would be adequate.

                           (d)      Amendments and Waivers.  Except as otherwise
                                    ----------------------
provided herein,  the provisions of this Agreement may not be amended,  modified
or  supplemented,  and  waivers or consents to  departures  from the  provisions
hereof may not be given  unless  consented  to in writing by all of the  parties
hereto.

                           (e)      Notices.  All  notices,  demands  and  other
                                    -------
communications  provided for or permitted hereunder shall be made in writing and
shall be made by  registered  or  certified  first-class  mail,  return  receipt
requested, telecopier, overnight courier service or personal delivery:

                                    (i)     if to QIP:

                                            Kaya Flamboyan 9,
                                            Villemstad
                                            Curacao
                                            Netherlands-Antilles

                                            with a copy to:

                                            Soros Fund Management LLC
                                            888 Seventh Avenue
                                            New York, NY 10016
                                            Telecopy:  (212) 664-0544
                                            Attn: Michael Neus, Esq.



<PAGE>

                                                             Page 81 of 83 Pages


                                        and a copy to:

                                        Paul, Weiss, Rifkind, Wharton & Garrison
                                        1285 Avenue of the Americas
                                        New York, New York 10019-6064
                                        Telecopy:      (212) 757-3990
                                        Attention:     Matthew Nimetz, Esq.

                           (ii)         If to SFM DI:

                                        Soros Fund Management LLC
                                        888 Seventh Avenue
                                        New York, NY 10016
                                        Telecopy:  (212) 664-0544
                                        Attn: Michael Neus, Esq.
                                        with a copy to:

                                        Paul, Weiss, Rifkind, Wharton & Garrison
                                        1285 Avenue of the Americas
                                        New York, New York 10019-6064
                                        Telecopy:      (212) 757-3990
                                        Attention:     Matthew Nimetz, Esq.

                           (iii)        if to the Company:

                                        Integra LifeSciences Corporation
                                        105 Morgan Lane
                                        Plainsboro, NJ 08536
                                        Telecopy:      (609) 799-3297
                                        Attention:     Stuart M. Essig,
                                                       President and CEO

                                        with a copy to:

                                        Drinker Biddle & Reath LLP
                                        105 College Road East
                                        Princeton, NJ 08542-0627
                                        Telecopy:     (609) 799-7000
                                        Attention:    John E. Stoddard III, Esq.

                            (iv)        if to any other  Designated  Holder,  at
                                        its   address   as  it  appears  on  the
                                        transfer books of the Company

                  All such  notices and  communications  shall be deemed to have
been duly given when delivered by hand, if personally delivered;  when delivered
by courier,  if delivered by commercial courier service;  five (5) Business Days
after being deposited in the mail, postage prepaid,  if mailed; and when receipt
is acknowledged, if telecopied.



<PAGE>

                                                             Page 82 of 83 Pages


                           (f)      Successors   and   Assigns;    Third   Party
                                    --------------------------------------------
Beneficiaries.  This Agreement shall inure to the benefit of and be binding upon
- -------------
the  successors  and assigns of each of the  parties  hereto.  The  registration
rights  and  the  other  rights  of the  Designated  Holders  contained  in this
Agreement shall be, with respect to any Registrable Security,  (i) automatically
transferred  from QIP or SFM DI, as the case may be, to any  Affiliate  thereof,
and (ii) in all other cases, transferred by the Designated Holders only with the
consent of the Company.  All of the  obligations of the Company  hereunder shall
survive any such  transfer.  No Person  other than the parties  hereto and their
successors  and permitted  assigns is intended to be a beneficiary of any of the
rights granted hereunder.

                           (g)      Counterparts. This Agreement may be executed
                                    ------------
in  any  number  of   counterparts   and  by  the  parties  hereto  in  separate
counterparts,  each of which when so executed  shall be deemed to be an original
and all of which taken together shall constitute one and the same agreement.

                           (h)      Headings. The headings in this Agreement are
                                    --------
for  convenience of reference  only and shall not limit or otherwise  affect the
meaning hereof.

                           (i)      GOVERNING  LAW.  THIS  AGREEMENT   SHALL  BE
                                    --------------
GOVERNED  BY AND  CONSTRUED  IN  ACCORDANCE  WITH THE  LAWS OF THE  STATE OF NEW
JERSEY, WITHOUT REGARD TO THE PRINCIPLES OF CONFLICTS OF LAW THEREOF.

                           (j)      Severability.  If  any  one or  more  of the
                                    ------------
provisions contained herein, or the application thereof in any circumstances, is
held  invalid,  illegal or  unenforceable  in any respect  for any  reason,  the
validity,  legality  and  enforceability  of any such  provision  in every other
respect and of the remaining provisions hereof shall not be in any way impaired,
it being  intended  that all of the  rights  and  privileges  of the  Designated
Holders shall be enforceable to the fullest extent permitted by law.

                           (k)      Entire Agreement. This Agreement is intended
                                    ----------------
by the parties as a final  expression  of their  agreement  and intended to be a
complete and  exclusive  statement of the  agreement  and  understanding  of the
parties hereto in respect of the subject matter contained  herein.  There are no
restrictions,  promises, warranties or undertakings,  other than those set forth
or referred to herein and in the Series B Agreement.  This Agreement  supersedes
all prior agreements and understandings between the parties with respect to such
subject matter.

                           (l)      Further  Assurances.  Each  of  the  parties
                                    -------------------
shall execute such  documents and perform such further acts as may be reasonably
required  or  desirable  to  carry  out or to  perform  the  provisions  of this
Agreement.



<PAGE>

                                                             Page 83 of 83 Pages


                  IN WITNESS  WHEREOF,  the undersigned  have executed,  or have
caused to be executed, this Agreement on the date first written above.


                                     INTEGRA LIFESCIENCES CORPORATION



                                     By:     /S/  STUART M. ESSIG
                                             ___________________________________
                                             Name:      Stuart M. Essig
                                             Title:     President and Chief
                                                        Executive Officer


                                     QUANTUM INDUSTRIAL PARTNERS LDC



                                     By:     /S/ MICHAEL C. NEUS
                                             ___________________________________
                                             Name:      Michael C. Neus
                                             Title:     Attorney-in-Fact
                                                        


                                     SFM DOMESTIC INVESTMENTS LLC



                                     By:     /S/ MICHAEL C. NEUS
                                             ___________________________________
                                             Name:      Michael C. Neus
                                             Title:    
                                                        





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