INTEGRA LIFESCIENCES HOLDINGS CORP
8-K, 2000-01-27
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
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<PAGE>


                       SECURITIES AND EXCHANGE COMMISSION

                              Washington, DC 20549


                                   -----------


                                    FORM 8-K

                                 CURRENT REPORT


                     Pursuant to Section 13 or 15(d) of the
                         Securities Exchange Act of 1934


Date of Report (Date of earliest event reported): January 14, 2000


                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION
            ---------------------------------------------------------
             (Exact name of registrant as specified in its charter)


          Delaware                    0-26224                   51-0317849
(State or other jurisdiction        (Commission               (IRS Employer
      of incorporation)             File Number)            Identification No.)



       105 Morgan Lane
       Plainsboro, New Jersey                                    08536
- ----------------------------------------                       ----------
(Address of principal executive offices)                       (Zip Code)


Registrant's telephone number,
including area code:  (609) 275-0500
                      --------------

                                       N/A
- --------------------------------------------------------------------------------
          (Former name or former address, if changed since last report)


<PAGE>


ITEM 2. Acquisition or Disposition of Assets.

     On January 14, 2000, Clinical Neuro Systems LLC, a Delaware limited
liability company (the "Purchaser") and an indirect wholly-owned subsidiary of
Integra LifeSciences Holdings Corporation (the "Company"), acquired
substantially all of the assets and assumed certain liabilities of Clinical
Neuro Systems, Inc., a Delaware corporation ("CNS"), and acquired certain assets
of Surgical Sales Corporation (trading as Connell Neurosurgical), a Pennsylvania
corporation and an affiliate of CNS ("Connell Neurosurgical"). The acquisition
was pursuant to an Asset Purchase Agreement (the "Purchase Agreement") dated as
of January 14, 2000 among the Purchaser, CNS, Connell Neurosurgical and George
J. Connell, the sole stockholder of each of CNS and Connell Neurosurgical. CNS
designs, manufactures and sells neurosurgical external ventricular drainage
systems, including catheters and drainage bags, as well as cranial access kits
(the "CNS Business"), and Connell Neurosurgical, among other things, distributes
the products of the CNS Business.

     The purchase price pursuant to the Purchase Agreement was $6.804 million,
comprised of $4.004 million in cash and a $2.8 million secured promissory note
which is payable in two equal installments on January 15, 2001 and January 14,
2002 (the "Note"). Pursuant to a Security Agreement and a Collateral Assignment,
the Purchaser pledged certain of its assets to CNS and George J. Connell to
secure repayment of the Note. George J. Connell will provide consulting services
to the Company for a period of one year.



                                      * * *


<PAGE>

ITEM 7.  Financial Statements, Pro Forma Financial Information and Exhibits.

Historical financial statements of CNS and pro forma financial information are
not included with this Report. Such financial information is not required
because CNS does not qualify as a "significant subsidiary" for purposes of such
disclosure under Rule 1-02(w) of Regulation S-X.


     (c) Exhibits.


Exhibit Number
(Referenced to
Item 601 of
Regulation S-K)               Description of Exhibit
- ---------------               ----------------------


2                   Asset Purchase Agreement, dated as of January 14, 2000,
                    among Clinical Neuro Systems Holdings LLC, Clinical Neuro
                    Systems, Inc., Surgical Sales Corporation (trading as
                    Connell Neurosurgical) and George J. Connell.*

10.1                Secured Promissory Note, dated January 14, 2000, from
                    Clinical Neuro Systems Holdings LLC to Clinical Neuro
                    Systems, Inc.

10.2                Security Agreement, dated as of January 14, 2000, among
                    Clinical Neuro Systems Holdings LLC, Clinical Neuro Systems,
                    Inc. and George J. Connell.

10.3                Collateral Assignment, dated as of January 14, 2000, from
                    Clinical Neuro Systems Holdings LLC to Clinical Neuro
                    Systems, Inc. and George J. Connell.

10.4                Subordinated Promissory Note, dated January 14, 2000, from
                    Integra LifeSciences Corporation to Clinical Neuro Systems
                    Holdings LLC.

10.5                Consulting Agreement, dated January 14, 2000, between
                    Integra LifeSciences Corporation and George J. Connell.

99                  Press Release of Integra LifeSciences Holdings Corporation
                    dated January 18, 2000.

- -------------
*     Integra agrees to furnish supplementally a copy of any
      omitted schedules or attachments to the Commission upon
      request.



<PAGE>

                                   SIGNATURES


     Pursuant to the requirements of the Securities Exchange Act of 1934, as
amended, Integra LifeSciences Holdings Corporation has duly caused this report
to be signed on its behalf by the undersigned hereunto duly authorized.

                                    INTEGRA LIFESCIENCES HOLDINGS CORPORATION



Date:  January 24, 2000            By:  /s/ Stuart M. Essig
                                         ------------------------------------
                                         Stuart M. Essig
                                         Chief Executive Officer


<PAGE>

                                INDEX OF EXHIBITS

Exhibit No.         Description of Exhibit
- -----------         ----------------------

 2                  Asset Purchase Agreement, dated as of January 14, 2000,
                    among Clinical Neuro Systems Holdings LLC, Clinical Neuro
                    Systems, Inc., Surgical Sales Corporation (trading as
                    Connell Neurosurgical) and George J. Connell.*

 10.1               Secured Promissory Note, dated January 14, 2000, from
                    Clinical Neuro Systems Holdings LLC to Clinical Neuro
                    Systems, Inc.

 10.2               Security Agreement, dated as of January 14, 2000, among
                    Clinical Neuro Systems Holdings LLC, Clinical Neuro Systems,
                    Inc. and George J. Connell.

 10.3               Collateral Assignment, dated as of January 14, 2000, from
                    Clinical Neuro Systems Holdings LLC to Clinical Neuro
                    Systems, Inc. and George J. Connell.

 10.4               Subordinated Promissory Note, dated January 14, 2000, from
                    Integra LifeSciences Corporation to Clinical Neuro Systems
                    Holdings LLC.

 10.5               Consulting Agreement, dated January 14, 2000, between
                    Integra LifeSciences Corporation and George J. Connell.

 99                 Press Release of Integra LifeSciences Holdings Corporation
                    dated January 18, 2000.

- --------------------
*         Integra agrees to furnish supplementally a copy of any omitted
          schedules or attachments to the Commission upon request.




<PAGE>

                                                                       Exhibit 2


                            ASSET PURCHASE AGREEMENT

                                  BY AND AMONG

                      CLINICAL NEURO SYSTEMS HOLDINGS LLC,

                          CLINICAL NEURO SYSTEMS, INC.,

          SURGICAL SALES CORPORATION (trading as CONNELL NEUROSURGICAL)

                                       AND

                                GEORGE J. CONNELL

                          DATED AS OF JANUARY 14, 2000



<PAGE>

                                TABLE OF CONTENTS

                                                                            Page
                                                                            ----

ARTICLE 1   PURCHASE AND SALE..................................................1
   1.1         CNS Purchased Assets............................................1
   1.2         Connell Neurosurgical Purchased Assets..........................3
   1.3         [Reserved]......................................................4
   1.4         Excluded Assets.................................................4
   1.5         Purchase Price..................................................4
   1.6         Assumption of Liabilities.......................................4
   1.7         Excluded Liabilities............................................5
   1.8         Assignability and Consents......................................6

ARTICLE 2   CLOSING............................................................7
   2.1         Closing.........................................................7
   2.2         Deliveries at Closing...........................................7

ARTICLE 3   REPRESENTATIONS AND WARRANTIES OF CNS..............................9
   3.1         Corporate Existence.............................................9
   3.2         Corporate Power and Authorization...............................9
   3.3         No Conflict....................................................10
   3.4         Compliance with Laws...........................................10
   3.5         Financial Statements...........................................11
   3.6         Books of Account...............................................12
   3.7         Title and Sufficiency..........................................12
   3.8         List of Properties, Contracts, etc.............................12
   3.9         Contracts......................................................13
   3.10        Product Design; Warranties.....................................13
   3.11        No Royalties or Similar Payments to Third Parties..............14
   3.12        Intellectual Property..........................................14
   3.13        Customers, Suppliers and Distributors..........................14
   3.14        Taxes..........................................................15
   3.15        No Undisclosed Liabilities.....................................15
   3.16        Employee Benefits..............................................15
   3.17        Labor Matters..................................................16
   3.18        Environmental Compliance.......................................16
   3.19        Litigation.....................................................18
   3.20        Employees......................................................18
   3.21        Absence of Changes or Events...................................19
   3.23        Accounts Receivable............................................20
   3.24        Finders or Brokers.............................................20
   3.25        Affiliate Agreements...........................................20
   3.26        Insurance......................................................21
   3.27        Export.........................................................21
   3.28        Full Disclosure................................................21

                                      -i-



<PAGE>

                                TABLE OF CONTENTS
                                  (continued)

                                                                            Page
                                                                            ----

ARTICLE 4   REPRESENTATIONS AND WARRANTIES OF CONNELL NEUROSURGICAL...........22
   4.1         Corporate Existence............................................22
   4.2         Corporate Power and Authorization..............................22
   4.3         No Conflict....................................................22
   4.4         Compliance with Laws...........................................23
   4.5         Books of Account...............................................23
   4.6         Title and Sufficiency..........................................24
   4.7         Contracts......................................................24
   4.8         Customers......................................................24
   4.9         Employees......................................................25
   4.10        Absence of Changes or Events...................................25
   4.11        Finders or Brokers.............................................25
   4.12        Full Disclosure................................................25

ARTICLE 5   REPRESENTATIONS AND WARRANTIES OF THE PURCHASER...................26
   5.1         Valid Existence................................................26
   5.2         Power and Authorization........................................26
   5.3         No Conflict....................................................26
   5.4         Brokers........................................................27
   5.5         Litigation.....................................................27
   5.6         SEC Reports....................................................27

ARTICLE 6   AGREEMENTS PENDING CLOSING........................................28
   6.1         Agreements of Sellers Pending the Closing......................28
   6.2         Negative Covenants.............................................29
   6.3         Transfer of Inventory..........................................30
   6.4         Agreements of the Sellers Pending the Closing..................30
   6.5         Access to Information; Confidentiality.........................30
   6.6         Best Efforts...................................................30
   6.7         Consents, Approvals, etc.......................................30
   6.8         Notice of Purchase and Sale of Assets..........................31

ARTICLE 7   EMPLOYEE BENEFITS AND EMPLOYMENT..................................31
   7.1         Employment.....................................................31
   7.2         Employee Benefit Plans.........................................31
   7.3         Health Care Continuation Coverage..............................31
   7.4         Reporting and Disclosure Requirements..........................32
   7.5         Employee Records...............................................32
   7.6         401(k) Accounts................................................32


                                      -ii-
<PAGE>

                                TABLE OF CONTENTS
                                  (continued)

                                                                            Page
                                                                            ----

ARTICLE 8   CERTAIN CONDITIONS PRECEDENT TO PURCHASER'S OBLIGATIONS...........32
   8.1         Representations and Warranties.................................32
   8.2         Performance of Covenants.......................................32
   8.3         Financial Position.............................................32
   8.4         Consents, Approvals, etc.......................................33
   8.5         Legal Matters..................................................33
   8.6         No Material Adverse Change.....................................33
   8.7         Opinion of Counsel.............................................33
   8.8         Closing Certificate............................................33
   8.9         Consulting Agreement...........................................33
   8.10        Closing Deliveries.............................................33

ARTICLE 9   CERTIAN CONDITIONS PRECEDENT TO OBLIGATIONS OF SELLERS............33
   9.1         Representations and Warranties.................................34
   9.2         Performance of Covenants.......................................34
   9.3         Approvals......................................................34
   9.4         Legal Matters..................................................34
   9.5         Closing Certificate............................................34
   9.6         Consulting Agreement...........................................34
   9.7         Closing Deliveries.............................................34

ARTICLE 10  CERTAIN POST-CLOSING MATTERS; COVENANTS...........................34
   10.1        Confidential Information.......................................34
   10.2        Covenant Not to Compete........................................34
   10.3        Assets, Authorizations, etc....................................35
   10.4        Use of Name....................................................36
   10.5        Satisfaction of Obligations....................................36
   10.6        Property Received..............................................36
   10.7        Preserve Value of Business.....................................36
   10.8        Payment of Intercompany Receivables............................36
   10.9        Permitted Development; Integra Right of First Offer............36
   10.10       Payroll Filings................................................37

ARTICLE 11  INDEMNIFICATION...................................................37
   11.1        Indemnification by Sellers.....................................37
   11.2        Indemnification by Purchaser...................................38
   11.3        Inter-Party Claims.............................................38
   11.4        Third Party Claims.............................................38
   11.5        Right of Set-Off...............................................39
   11.6        Limitations....................................................39


                                     -iii-
<PAGE>

                                TABLE OF CONTENTS
                                  (continued)

                                                                            Page
                                                                            ----

ARTICLE 12  TERMINATION.......................................................40
   12.1     Termination.......................................................40
   12.2     Procedure for Termination.........................................40
   12.3     Effect of Termination.............................................40

ARTICLE 13  MISCELLANEOUS.....................................................40
   13.1     Knowledge.........................................................40
   13.2     Survival of Representations and Warranties........................40
   13.3     Notification of Certain Events....................................41
   13.4     Costs and Expenses................................................41
   13.5     Notices...........................................................41
   13.6     Assignment and Benefit............................................42
   13.7     Amendment, Modification and Waiver................................42
   13.8     Governing Law; Consent to Jurisdiction............................43
   13.9     Public Announcements..............................................43
   13.10    Further Actions and Assurances....................................43
   13.11    Section Headings and Defined Terms................................43
   13.12    Severability......................................................44
   13.13    Counterparts......................................................44
   13.14    Entire Agreement, etc.............................................44



                                      -iv-
<PAGE>

                            ASSET PURCHASE AGREEMENT

     THIS ASSET PURCHASE AGREEMENT is entered into as of January 14, 2000, by
and among CLINICAL NEURO SYSTEMS HOLDINGS LLC, a Delaware limited liability
company ("Purchaser") and a wholly-owned subsidiary of Integra LifeSciences
Corporation ("Integra"), CLINICAL NEURO SYSTEMS, INC., a Delaware corporation
("CNS"), SURGICAL SALES CORPORATION trading as CONNELL NEUROSURGICAL, a
Pennsylvania corporation and an affiliate of CNS ("Connell Neurosurgical" and,
together with CNS, the "Sellers"), and GEORGE J. CONNELL.

                                   BACKGROUND

     This Agreement sets forth the terms and conditions upon which Purchaser is
purchasing (a) substantially all of the assets used by CNS in the conduct of its
business (the "Business") related to the manufacture or assembly of cerebral
spinal fluid drainage systems and cranial access kits (the "CNS Products") and
(b) certain assets of Connell Neurosurgical relating to or used in connection
with the sale, marketing or distribution of the CNS Products (the "CN
Business"), in exchange for the payment by Purchaser of the Purchase Price
hereinafter described and the assumption by Purchaser of certain specified
liabilities.

     NOW, THEREFORE, in consideration of the respective covenants,
representations, warranties and agreements herein contained, the parties hereto,
intending to be legally bound, hereby agree as follows:


                                   Article 1

                                PURCHASE AND SALE

     1.1 CNS Purchased Assets. Subject to the terms and conditions set forth in
this Agreement, at the Closing (as defined herein), CNS shall sell, convey,
assign and transfer to Purchaser, and Purchaser shall purchase from CNS, all
right, title and interest of CNS in and to all of the tangible and intangible
properties and assets owned or held by CNS and relating to or used, or held for
use, in connection with the Business (collectively, the "CNS Assets"), free and
clear of all Liens (as defined in Section 2.2(a) herein), including, without
limitation, the following assets, but excluding the Excluded Assets (as defined
herein):

        (a) all prepaid expenses, advance payments, deposits, surety accounts
and other similar assets, including, without limitation, prepaid deposits
with suppliers and utilities;

        (b) all inventory (including inventory of Connell Neurosurgical that
is transferred to CNS pursuant to Section 6.3 hereof), including raw
material, work-in-process and finished goods inventory of products, supplies
and parts, of CNS;


<PAGE>

        (c) all tangible personal property related to the Business, including
without limitation all CSF drains, drill kits, catheters, machinery,
equipment, vehicles, furniture, computers, printers and other peripheral
computer equipment, pagers, and cellular telephones set forth on Schedule
1.1(c) and the supplies and spare parts related thereto, subject to any
changes in such items as shall occur in the ordinary course of business
consistent with past practice between the date hereof and the Closing;

        (d) all accounts receivable owing from Connell Neurosurgical to CNS
and, subject to Section 10.6 hereof, any payments received with respect
thereto after the Closing Date (as defined herein), and unpaid interest
accrued on any such accounts receivable (the "Accounts Receivable");

        (e) all contracts, agreements, commitments, licenses, leases,
undertakings, arrangements and other legally binding contractual rights or
obligations to which CNS is a party and which are listed on Schedule 1.1(e),
including without limitation all distribution contracts, sterilization
contracts and price protection contracts (collectively, the "Contracts");

        (f) all existing supplier lists, customer lists, pricing lists,
records, books, ledgers, files, documents, correspondence, advertising,
promotional and marketing materials (including without limitation catalogues,
brochures, trade show equipment, field inventory, loaners, pole mounts, sales
force inventory and consignments), studies and reports (collectively,
"Records") related primarily to the Business;

        (g) the names "CNS" and "Clinical Neuro Systems, Inc." and any
similar sounding names and variants thereof and any other names used by CNS
in the marketing materials or on the products of the Business, however
labeled, and all trademarks, tradenames, copyrights and other intellectual
property rights that are used in the Business (collectively, the
"Intellectual Property"), including without limitation all trademarks,
tradenames, copyrights and other intellectual property rights set forth on
Schedule 1.1(g);

        (h) all inventions, discoveries, software, shop rights, licenses,
developments, research data, designs, technology, trade secrets, test
procedures, processes, research data, formulas and other confidential
information used primarily in the Business;

        (i) all rights, claims and benefits of CNS in, to or under any (i)(A)
employee confidentiality agreements entered into by CNS and (B)
confidentiality or secrecy agreements entered into by CNS with third parties
that relate to the use or disclosure of information concerning the Assets or
the Business, and (ii) express or implied warranties from the suppliers of
goods or services (including any coverage rights under product liability or
other insurance maintained by any of such suppliers for the benefit of CNS);

        (j) all unfilled purchase and sale orders of CNS related to the
Business and all cash related thereto;

        (k) all licenses, permits, approvals, variances, waivers or consents
issued by any foreign, United States, state or local governmental entity or
subdivision thereof or any


                                     -2-
<PAGE>

authority, department, commission, board, bureau, agency, court or
instrumentality (each, a "Governmental Authority" and collectively,
"Governmental Authorities") used in or necessary to the operation of the
Business (collectively, the "Permits"), to the extent transferable;

        (l) all fixtures, machinery, apparatus and equipment of CNS affixed
to the Exton Property (as defined herein);

        (m) the goodwill of the Business as a going concern; and

        (n) all other assets, properties and rights of CNS of every kind
associated with the Business, whether tangible or intangible, real, personal
or mixed, and wherever situated including, without limitation, those assets,
properties and rights set forth on the Financial Statements (as defined
herein).

     1.2 Connell Neurosurgical Purchased Assets. Subject to the terms and
conditions set forth in this Agreement, at the Closing, Connell Neurosurgical
shall sell, convey, assign and transfer to Purchaser, and Purchaser shall
purchase from Connell Neurosurgical, all right, title and interest of Connell
Neurosurgical in and to all of the tangible and intangible properties and
assets owned or held by Connell Neurosurgical relating to or used, or held
for use, in connection with the CN Business (the "Connell Neurosurgical
Assets"), free and clear of all Liens, including, without limitation, the
following assets, but excluding the Excluded Assets:

        (a) The Lease Agreement (the "Exton Lease") relating to the real
property located at 309 Commerce Drive, Exton, Pennsylvania (the "Exton
Property");

        (b) The customer list of the CN Business;

        (c) All contracts, agreements, commitments, licenses, leases,
undertakings, arrangements and other legally binding contractual rights or
obligations to which Connell Neurosurgical is a party and which are related
to the CN Business, including without limitation those listed on Schedule
1.2(c)(collectively, the "CN Contracts");

        (d) All rights, claims and benefits of Connell Neurosurgical in, to
or under any (i) employee confidentiality agreements entered into by Connell
Neurosurgical and (ii) confidentiality or secrecy agreements entered into by
Connell Neurosurgical with third parties that relate to the use or disclosure
of information concerning the Assets or the CN Business;

        (e) The promotional binders, booth graphics, product literature,
product samples and educational materials used in or related to the CN
Business;

        (f) Any names used by Connell Neurosurgical in the marketing
materials or on the products of the CN Business, however labeled, to the
extent transferable under law; and

        (g) All unfilled purchase and sale orders of Connell Neurosurgical
related to the CN Business and all cash related thereto.





                                     -3-
<PAGE>

     1.3 [Reserved]

     1.4 Excluded Assets. Expressly excluded from the assets, properties
and rights being sold by Sellers to Purchaser pursuant to Sections 1.1 and
1.2 hereof are the following (collectively, the "Excluded Assets"):

        (a) cash, except for cash attributable to unfilled sales orders;

        (b) all claims for Tax (as defined herein) refunds to the extent such
refunds relate to periods ending on or prior to the Closing;

        (c) all minute books, corporate records and income Tax returns; and

        (d) all other assets, properties and rights, if any, listed on
Schedule 1.4(d).

     1.5 Purchase Price.

        (a) The total consideration for the Assets shall be $6,804,000, plus
the assumption of the liabilities specified in Section 1.6 (the "Purchase
Price"). The Purchase Price (i.e., the cash and promissory note component
thereof) for the Assets shall be paid by Purchaser at Closing as follows: (i)
an aggregate amount in cash equal to $4,004,000 (the "Closing Payment"), and
(ii) a secured promissory note from the Purchaser to CNS in the principal
amount of $2,800,000, in the form of Exhibit A attached hereto (the "Note").

        (b) The Purchase Price shall be allocated among the Assets acquired
hereunder and the covenants not to compete set forth in Section 10.2 hereof
in the manner set forth on Schedule 1.5(b). Any indemnification payment
treated as an adjustment to the Purchase Price pursuant to Article 11 shall
be reflected as an adjustment to the amount set forth on Schedule 1.5(b) that
is allocated to the specific asset, if any, giving rise to the adjustment,
and if any such adjustment does not relate to a specific asset, such
adjustment shall be allocated among the Assets acquired hereunder in
accordance with Section 1060 of the Internal Revenue Code of 1986, as amended
(the "Code"), and the regulations thereunder. The Purchaser and each Seller
and George J. Connell shall each prepare and file their respective Tax
Returns (as defined herein), including, without limitation, Asset Acquisition
Statements on IRS Form 8594, employing the allocation made pursuant to this
Section 1.5(b) and shall not take a position in any Tax proceeding or audit
or otherwise that is inconsistent with such allocation unless otherwise
clearly required by Law. The Purchaser, on the one hand, and the Sellers, on
the other hand, shall give prompt notice to the other of the commencement of
any Tax audit or the assertion of any proposed deficiency or adjustment by
any taxing authority or agency that challenges such allocation.

     1.6 Assumption of Liabilities. At the Closing, Purchaser shall assume
and agree to pay, discharge or perform, as appropriate, the following and
only the following liabilities and obligations (collectively, the "Assumed
Liabilities"):

        (a) all accounts payable CNS of listed on Schedule 1.6(a) (excluding
accounts payable, if any, to affiliates of CNS) existing as of the Closing
Date that relate to the Business


                                     -4-
<PAGE>

and that were incurred in the ordinary course of business, and that
were not paid as of the Closing Date in the ordinary course of business
consistent with past practice;

        (b) accrued salaries, wages, vacation and sick pay (and Taxes with
respect to such items) with respect to Transferred Employees (as defined
herein) of CNS and Connell Neurosurgical listed in Section 7.1(b) of the
Disclosure Statement existing as of the Closing Date (except to the extent
specifically excluded in Section 1.7 hereof), and any other liabilities and
obligations with respect to such employees to the extent expressly provided
in Section 7.3 hereof;

        (c) all liabilities and obligations of CNS arising under the
Contracts, including unfilled sale orders assigned to Purchaser pursuant to
Section 1.1(j) hereof; provided, however, that Purchaser shall not assume or
be responsible for, but shall be indemnified with respect to, any liabilities
or obligations which arise from breaches of such Contracts or defaults
thereunder by CNS prior to the Closing;

        (d) all liabilities and obligations of Connell Neurosurgical arising
under the CN Contracts, including unfilled sale orders assigned to Purchaser
pursuant to Section 1.2(g) hereof; provided, however, that Purchaser shall
not assume or be responsible for, but shall be indemnified with respect to,
any liabilities or obligations which arise from breaches of such CN Contracts
or defaults thereunder by Connell Neurosurgical prior to the Closing;

        (e) the Exton Lease; and

        (f) liabilities for bodily injury to any person or damage to any
property arising out of or relating to any product manufactured or assembled
by CNS related to the Business prior to the Closing, except for product
liability claims existing on the Closing Date or potential product liability
claims of which either Seller had knowledge on the Closing Date.

     1.7 Excluded Liabilities. Except as expressly provided in Section 1.6
hereof, Purchaser shall not assume or become responsible for any liability or
obligation of either Seller, whether accrued, absolute or contingent, known
or unknown, including, without limitation, liabilities arising under all
contracts not identified on Schedule 1.1(e) hereto or on Schedule 1.2(c)
hereto, any accounts payable not identified on Schedule 1.6(a) hereof, any
liabilities under any Employee Benefit Plan (as defined in Section 3.16
herein), any medical, life, or disability insurance policies, any workman
compensation claims, any federal, state, or local payroll or other tax
liabilities, liabilities relating to claims for damages based upon the breach
by either Seller of any federal, state or local environmental or occupational
health and safety laws or regulations, liabilities relating to any litigation
(other than products liability litigation or tort claims relating to
liabilities assumed pursuant to Section 1.6(f)), any undisclosed liabilities,
liabilities incurred for the costs and expenses of negotiating and
consummating the transactions contemplated by this Agreement, liabilities
incurred in connection with the termination of any of the Contracts to be
transferred hereunder for which consent of the other party thereto is
required but not obtained, liabilities related to the classification of
independent contractors, tort claims asserted against Sellers or claims
against Sellers for breach of contract which are based on acts or omissions
of Sellers occurring on, before or after the Closing, liabilities under any
phantom stock


                                     -5-
<PAGE>

agreements and/or similar agreements with or for the benefit of
any employees of the Business (including, without limitation, the Stock
Appreciation Agreement between Connell Neurosurgical and Peter Ligotti dated
July 7, 1999, the Stock Appreciation Agreement between Connell Neurosurgical
and Brian Larkin dated December 15, 1997, and the Stock Appreciation
Agreement between Connell Neurosurgical and Kristen Fuette dated January 1,
1999), liabilities for any royalties or similar payment due to third parties,
liabilities for any change in control or parachute payments, liabilities for
any Christmas, end-of-year or other bonuses or special payments to any
employees of the Business (even if already accrued for by either Seller), any
liabilities related to products liability claims existing on the Closing Date
or potential products liability claims of which either Seller had knowledge
on the Closing Date, and any liabilities for legal fees and expenses,
auditing fees and expenses and investment bankers' or brokers' fees,
commissions and expenses.

     1.8 Assignability and Consents.

        (a) Required Consents. Section 1.8 of the Disclosure Statement (as
defined herein) sets forth a list of all Assets, except Permits, which are
non-assignable or non-transferable to Purchaser without the consent of some
other individual, partnership, corporation, association, joint stock company,
trust, joint venture, limited liability company or Governmental Authority
(collectively, "Person"). The Sellers have commenced and shall continue to
take, or cause to be taken by others, all necessary actions required to
obtain or satisfy, at the earliest practicable date, all consents, novations,
approvals, authorizations, requirements (including filing and registration
requirements), waivers and agreements ("Consents") from any Persons necessary
to authorize, approve or permit the full and complete sale, conveyance,
assignment or transfer of the Assets listed on Section 1.8 of the Disclosure
Statement, and shall continue such efforts as may be required after the
Closing Date to facilitate the full and expeditious transfer of legal title
of such Assets.

        (b) Nonassignable Items. Anything in this Agreement to the contrary
notwithstanding, this Agreement shall not constitute an agreement to sell,
convey, assign, sublease or transfer any Assets, if an attempted sale,
conveyance, assignment, or transfer thereof, without the Consent of another
party thereto or a Governmental Authority, would constitute a breach of, or
in any way affect the rights of the Sellers or the Purchaser with respect to,
such Asset ("Nonassignable Items"). The Sellers shall use their best efforts
and the Purchaser shall cooperate in all reasonable respects with the Sellers
to obtain and satisfy all Consents and to resolve all impracticalities of
sale, conveyance, assignment, or transfer necessary to convey to Purchaser
all Nonassignable Items listed on Section 1.8 of the Disclosure Statement. If
any such Consents are not obtained and satisfied or if an attempted sale,
conveyance, assignment, or transfer would be ineffective, the Sellers shall
at the Closing enter into such arrangements (including related written
agreements) as the Purchaser may reasonably request in order to fairly
compensate Purchaser for the loss of, or to provide to Purchaser the benefit
of, any such Nonassignable Items (it being acknowledged that such arrangement
may include obligations imposed on the Sellers promptly to pay to the
Purchaser when received all monies and other items of value received by the
Sellers under any such Nonassignable Item).


                                     -6-
<PAGE>

                                  ARTICLE 2

                                   CLOSING

     2.1 Closing. Subject to the conditions contained herein, the closing
(the "Closing") of the sale and purchase of the Assets shall take place at
10:00 A.M., local time, on January 14, 2000, at the offices of Drinker Biddle
& Shanley LLP, 105 College Road East, Suite 300, Princeton, NJ 08542, or on
such other date or time and/or at such other place as may be mutually agreed
upon in writing by the Purchaser and the Sellers. The date of the Closing is
sometimes herein referred to as the "Closing Date."

     2.2 Deliveries at Closing. At the Closing, in addition to the other
actions contemplated elsewhere herein:

        (a) The Sellers shall deliver to the Purchaser the following:

           (i) a bill of sale and assignment, duly executed by each Seller,
conveying to Purchaser all of such Seller's right, title and interest in and
to all of the CNS Assets and the Connell Neurosurgical Assets, respectively
(collectively, the "Assets"), free and clear of any and all liens, equities,
claims, prior assignments, mortgages, deeds of trust, charges, security
interests, pledges, conditional sales contracts, restrictions or encumbrances
whatsoever (collectively, "Liens");

           (ii) certified copies of the resolutions duly adopted by the Board of
Directors and stockholders of each Seller authorizing the execution, delivery
and performance of this Agreement and the consummation of the transactions
contemplated hereby;

           (iii) copies of all required Consents;

           (iv) instruments of assignment to Purchaser of all Intellectual
Property (and all applications for, and extensions and reissuances of, any of
the foregoing and rights therein);

           (v) good standing certificates for CNS from the Delaware Secretary of
State and the Pennsylvania Secretary of State and a good standing certificate
for Connell Neurosurgical from the Pennsylvania Secretary of State, each
dated not more than ten (10) days prior to the Closing Date;

           (vi) releases, including, without limitation, termination statements
under the Uniform Commercial Code of any financing statements filed against
any Assets, evidencing discharge, removal and termination of all Liens to
which the Assets are subject (including, without limitation, the Liens of
National Penn Bank f/k/a National Bank of Boyertown), which releases shall be
effective at or prior to the Closing;

           (vii) all books and Records of CNS maintained with respect to the
Business, except for minute books, corporate records and income Tax returns;



                                     -7-
<PAGE>

           (viii) the written consent or approval of the owner of the Exton
Property with respect to the assignment of the lease agreement for the Exton
Property from Connell Neurosurgical to Purchaser;

           (ix) a Subordination, Nondisturbance and Attornment Agreement, in
form satisfactory to Purchaser, executed by any Persons having a mortgage on
the Exton Property;

           (x) the legal opinion of Duane, Morris & Heckscher LLP, counsel to
Sellers and George J. Connell, substantially in the form of Exhibit B
attached hereto (the "Sellers' Opinion");

           (xi) evidence that Sellers have complied with the notice requirements
of 72 P.S. Section 7240 as described in Section 6.7 hereof;

           (xii) a lease agreement for the Warehouse from George J. Connell to
Purchaser, which lease agreement shall have a term of three (3) months and
shall be otherwise satisfactory in form and substance to Purchaser;

           (xiii) evidence satisfactory to Purchaser that the sub-lease of the
Exton Property by Connell Neurosurgical to CNS has been terminated; and

           (xiv) such other documents or instruments as the Purchaser reasonably
requests to effect the transactions contemplated hereby.

        (b) The Purchaser shall deliver to the Sellers the following:

           (i) a wire transfer in the amount of the Closing Payment in same day
funds pursuant to instructions given by the Sellers to the Purchaser for that
purpose;

           (ii) the Note;

           (iii) a subordinated promissory note in the principal amount of
$2,800,000 issued by Integra to Purchaser, substantially in the form of
Exhibit A-1 attached hereto (the "Parent Note");

           (iv) an assumption agreement, duly executed by Purchaser, in form and
substance reasonably satisfactory to the Sellers, pursuant to which Purchaser
will assume all of the Assumed Liabilities;

           (v) certified copies of the resolutions duly adopted by the Board of
Directors of Integra authorizing (A) Purchaser's execution, delivery and
performance of this Agreement and the consummation of the transactions
contemplated hereby and (B) the execution, delivery and performance by
Integra of the Consulting Agreement referenced in Section 8.9 hereof and the
Parent Note;


                                     -8-
<PAGE>

           (vi) a good standing certificate for Purchaser and Integra from the
Delaware Secretary of State, dated not more than ten days prior to the
Closing Date;

           (vii) a Security Agreement in the form attached hereto as Exhibit C
and executed financing statements on Form UCC-1 (all of which shall be
prepared by and provided by Sellers or their counsel) granting to CNS a
security interest in certain of the Assets as collateral to secure the
repayment of the Note;

           (viii) a Collateral Assignment in the form attached hereto as Exhibit
C-1 collaterally assigning to CNS and George J. Connell the Parent Note as
additional collateral to secure repayment of the Note;

           (ix) a Joinder and Guaranty Agreement in the form attached hereto as
Exhibit D executed by CNS Acquisition in favor of CNS and George J. Connell;

           (x) the legal opinion of Drinker Biddle & Reath LLP, counsel to
Purchaser, substantially in the form of Exhibit E attached hereto; and

           (xi) such other documents or instruments as the Sellers reasonably
request to effect the transactions contemplated hereby.


                                  ARTICLE 3

                      REPRESENTATIONS AND WARRANTIES OF CNS

     CNS hereby represents and warrants to the Purchaser that, except as
set forth on the Disclosure Statement (the "Disclosure Statement") delivered
to the Purchaser by CNS:

     3.1 Corporate Existence. CNS is a corporation duly organized, validly
existing and in good standing under the laws of its jurisdiction of
incorporation and has the requisite corporate power and authority to own,
lease and operate its properties and assets and to carry on the Business as
now being conducted. CNS is duly qualified to do business and is in good
standing as a foreign corporation in each jurisdiction where the conduct of
the Business by it requires it to be so qualified except where the failure to
be so qualified would not have a Material Adverse Effect on CNS. For purposes
of this Agreement, the term "Material Adverse Effect" when used in respect to
any party means a material adverse effect on the assets, business, financial
condition, results of operations or prospects of that party.

     3.2 Corporate Power and Authorization. CNS has the corporate power
and authority to execute, deliver and perform its obligations under this
Agreement. The execution, delivery and performance of this Agreement by CNS
have been duly and validly authorized by all necessary corporate action. This
Agreement has been, and the other agreements, documents, certificates and
instruments required to be delivered by CNS in accordance with the provisions
hereof (collectively, the "CNS Transaction Documents") will be, duly executed
and delivered by CNS, and this Agreement constitutes, and the CNS Transaction
Documents when executed and


                                     -9-
<PAGE>

delivered by CNS will constitute, the legal, valid and binding obligation
of CNS, enforceable against CNS in accordance with their respective terms,
except to the extent that enforceability may be limited by bankruptcy,
insolvency, moratorium or other similar laws presently or hereafter in effect
relating to or affecting the enforcement of creditors' rights generally and
by general principles of equity (regardless of whether enforcement is
considered in a proceeding in equity or at law).

     3.3 No Conflict.

        (a) The execution, delivery and performance of this Agreement and the
CNS Transaction Documents do not and will not (with or without the passage of
time or the giving of notice):

           (i) violate or conflict with any law, regulation, permit, license,
certificate, judgment, order, award or other decision or requirement of any
arbitrator or Governmental Authority, domestic or foreign (collectively,
"Laws");

           (ii) violate or conflict with, result in a breach of, or constitute a
default or otherwise cause any loss of benefit under, any agreement or
contract, or give to others any rights (including rights of termination,
foreclosure, cancellation or acceleration) in or with respect to any of the
Assets; or

           (iii) result in, require or permit the creation or imposition of any
Lien of any nature upon or with respect to the Assets.

There are no judicial, administrative or other governmental actions, proceedings
or investigations pending against CNS or, to the knowledge of CNS, threatened,
that question any of the transactions contemplated by, or the validity of, this
Agreement or any of the other agreements or instruments contemplated hereby or
which, if adversely determined, is likely to have an adverse effect upon the
ability of CNS to enter into or perform its obligations under this Agreement or
any such other agreements or instruments. CNS has not received any request from
any Governmental Authority for information with respect to the transactions
contemplated hereby.

     3.4 Compliance with Laws.

        (a) Except as described in the Disclosure Statement, the operation of
the Business and the Assets is, and at all times during the last three (3)
years has been, in compliance in all material respects with all applicable
Laws including, without limitation, all environmental Laws, rules and
regulations, and CNS has no basis to expect, and have not received, with
respect to the Assets or the operation of the Business during the last three
(3) years, any notice, order or other communication from any Governmental
Authority of any alleged, actual, or potential violation of or failure to
comply with any Law including, without limitation, any environmental Law.

        (b) Except as described in the Disclosure Statement and except as
would not have a Material Adverse Effect, all federal, foreign, state, local
and other governmental consents,


                                    -10-
<PAGE>

licenses, Permits, franchises, grants and authorizations (each, an
"Authorization" and collectively, "Authorizations") required for the
operation of the Business as currently conducted and as conducted during the
last three (3) years are in full force and effect without any default or
violation thereunder by CNS or by any other party thereto and CNS has not
received any notice of any claim or charge that CNS is or within the last
three (3) years has been in violation of or in default under any such
Authorization. The Disclosure Statement includes a list of all such
Authorizations in the possession of CNS.

        (c) As to each product of the Business subject to the jurisdiction of
the Food and Drug Administration under the Federal Food, Drug and Cosmetic
Act, as amended ("FDCA"), or the Prescription Drug Marketing Act ("PDMA") and
the jurisdiction of the Drug Enforcement Agency under the Comprehensive Drug
Abuse Prevention and Control Act of 1970 ("CSA") which is manufactured,
tested, distributed, held, sold, and/or marketed by CNS, such product is
being manufactured, held and distributed in compliance in all material
respects with all applicable requirements under the FDCA, PDMA and the CSA
including, but not limited to, those relating to investigational use,
premarket clearance, good manufacturing practices, labeling, promotion and
advertising, record keeping, filing of reports and security.


     3.5 Financial Statements.

        (a) CNS has delivered to the Purchasers copies of the unaudited
financial statements of CNS at and for the years ended December 31, 1996,
1997 and 1998 and for the eleven months ended November 30, 1999 (the balance
sheet for which is herein referred to as the "CNS Interim Date Balance
Sheet") (collectively, the "CNS Financial Statements"). Such CNS Financial
Statements are true and correct and fairly present the financial position,
assets and liabilities of CNS at and as of the dates indicated and the
results of operations of CNS for the periods indicated, subject, on interim
statements, to changes resulting from year-end adjustments which individually
or in the aggregate will not be material.

        (b) Except as described in the Disclosure Statement, since November
30, 1999, CNS has conducted the Business only in the ordinary course
consistent with past practice and has not: (i) incurred any material
liabilities or entered into any transaction, contract or arrangement except
in the ordinary course of business consistent with past practice; or (ii)
changed any of the accounting principles followed by it or the methods of
applying such principles. Since November 30, 1999, except as described in the
Disclosure Statement, there has been (a) no change in the financial
condition, prospects, assets, liabilities or business of CNS which has had or
could reasonably be expected to have an adverse effect on the Business or the
Assets; (b) no damage, destruction or loss (whether or not covered by
insurance) adversely affecting the Business or the Assets; (c) no labor
dispute adversely affecting the Business or the Assets; (d) no sale or
transfer of any Assets, except sales in the ordinary course of business,
consistent with past practice; (e) no imposition of any Lien or claim upon
any Assets; (f) no default in any liability or obligation of CNS which has
had or could reasonably be expected to have an adverse effect on the Business
or the Assets and; (g) no agreement by CNS to any change in the terms of any
agreement, license or instrument which is a party which has had or could
reasonably be expected to have an adverse effect on the Business or the
Assets.



                                    -11-
<PAGE>

        (c) CNS has no material liabilities with respect to the Business
(whether known or unknown, whether absolute or contingent, whether liquidated
or unliquidated and whether due or to become due), except for (i) liabilities
shown on the CNS Interim Date Balance Sheet; (ii) liabilities which have
arisen since the date of the CNS Interim Date Balance Sheet in the ordinary
course of business consistent with past practice, and (iii) contractual and
other liabilities incurred in the ordinary course of business consistent with
past practice which are not required by generally accepted accounting
principles ("GAAP") to be reflected on a balance sheet; and (iv) liabilities
excluded pursuant to Section 1.7.

     3.6 Books of Account. The books, records and accounts of CNS
maintained with respect to the Business reflect all transactions and all
assets and liabilities of CNS with respect to the Business.

     3.7 Title and Sufficiency. (a) CNS has, and will convey to Purchaser
at Closing, good and valid title to all of the CNS Assets, free and clear of
any Liens; (b) all CNS Assets owned or leased by CNS and used or held for use
in the Business are in the possession or under the control of CNS, are
suitable for the purposes for which they are currently being used, and are of
a condition, nature and quantity sufficient for the conduct of the Business
as it is presently conducted; and (c) the Assets and the Excluded Assets
constitute all of the assets used in the Business and the CN Business.

     3.8 List of Properties, Contracts, etc. The Disclosure Statement
lists or adequately describes the following:

        (a) Each item of machinery, equipment and other tangible asset
included in the CNS Assets;

        (b) Each Authorization employed in the Business;

        (c) Each (i) fictitious business name, tradename, registered and
unregistered trademark, service mark and related application (the "Marks"),
(ii) patent, patent right and patent application (collectively, "Patents"),
(iii) copyright in published and material unpublished works ("Copyrights"),
and software, (iv) proprietary formula, trade secret, formulation and
invention ("Trade Secrets"), and (v) license and permit issued or granted by
any person relating to any of the foregoing; in each case included in the
Assets and owned, leased, used or held by, granted to or licensed by CNS as
either licensor or licensee, together with all other interests therein
granted by CNS to any other person and all agreements with respect to any of
the foregoing to which CNS is a party;

        (d) Each contract, agreement or commitment which restricts or
purports to restrict any business activities or freedom of CNS or its
officers, employees or consultants to engage in the Business or to compete
with any person;

        (e) Each contract, agreement or commitment relating to the Business
to which CNS is a party or is otherwise bound providing for payments
(contingent or otherwise) to or by any person or entity based on sales,
purchases or profits, other than direct payments for goods,


                                    -12-
<PAGE>

and each other contract, agreement or commitment relating to the Business
to which CNS is a party or by which it or any Assets are otherwise bound which
is material to its business, operation, financial condition or prospects;

        (f) Each form of contract, employee non-disclosure and
non-competition agreement or commitment used by CNS as a standard form in the
ordinary course of the Business;

        (g) Each insurance claim made or loss incurred relating to the
Business in the preceding two (2) years pursuant to any workers'
compensation, liability or other insurance policy of CNS; and

        (h) Each outstanding power-of-attorney or similar power relating to
the Business granted by CNS for any purpose whatsoever.

CNS has furnished or, on request, will furnish or make available to Purchaser
true and complete copies of each agreement, plan and other document required to
be disclosed on the Disclosure Statement.

      3.9 Contracts.

        (a) The Disclosure Statement contains a list of each contract (or
group of related contracts) to which CNS is a party that is not terminable at
will by CNS. The Disclosure Statement contains a list of all distribution
contracts with domestic or foreign persons, whether such contracts are
written or oral.

        (b) Except as described in the Disclosure Statement:

            (i) each contract referred to in Section 3.9(a) was made in the
ordinary course of business consistent with past practice, is in full force
and effect and is valid, binding and enforceable against the parties thereto
in accordance with its terms;

            (ii) CNS has performed all obligations required to be performed by
it under each contract referred to in Section 3.9(a), and no condition exists or
event has occurred which with notice or lapse of time would constitute a default
or a basis for delay or non-performance by CNS or, to the best knowledge of CNS,
by any other party thereto; and

            (iii) each other party to each contract referred to in Section
3.9(a) has consented or been given sufficient notice (where such consent or
notice is necessary) that the same shall remain in full force and effect
following the Closing.

     3.10 Product Design; Warranties.

        (a) A copy of each standard warranty of CNS is included in the
Disclosure Statement. Except as set forth in such standard warranties or as
otherwise described in the Disclosure Statement: (a) CNS has not agreed to be
responsible for consequential damages or made any express warranties to third
parties with respect to any products created, manufactured,


                                    -13-
<PAGE>

sold or distributed by CNS, or any services rendered by CNS; (b) there are no
warranties (express or implied) outstanding with respect to any such
products or services other than any such implied by law pursuant to Sections
2-312 and 2-314 of the Uniform Commercial Code; (c) such products are not
subject to any guaranty, indemnity or right of return; and (d) there are no
design, manufacturing or other defects, latent or otherwise, with respect to
any such products known to CNS.

        (b) A complete list of all complaints received by CNS during the last
three years with respect to products manufactured by CNS is attached to the
Disclosure Statement. All such complaints were resolved consistently with
CNS' quality systems and applicable governmental regulations.


     3.11 No Royalties or Similar Payments to Third Parties. There are no
royalties or other similar payments due to third parties in respect of any
products of the Business.

     3.12 Intellectual Property.

        (a) Except as described in the Disclosure Statement, CNS is the sole
owner of, or have the exclusive perpetual rights to use without
consideration, all Intellectual Property, free and clear of any Lien or other
adverse claim known to CNS; the Intellectual Property is subsisting and, to
the knowledge of CNS, is not invalid or unenforceable, in whole or in part;
CNS has not granted or licensed to any person any rights with respect to any
Intellectual Property and no other person has any rights in or to any of the
Intellectual Property (including, without limitation, any rights to market or
distribute any of the Intellectual Property); the Intellectual Property is
sufficient for the conduct of the Business as it is presently conducted; to
the knowledge of CNS, there has been no infringement, unauthorized use,
breach of confidentiality obligations or disclosure or misappropriation by
any person or entity, of any Intellectual Property; and the use of the
Intellectual Property does not infringe, misappropriate, misuse or violate
the rights of any others in any Intellectual Property and, to CNS' knowledge,
is not alleged to have infringed, misappropriated, misused or violated the
rights of any others in any Intellectual Property.

        (b) Except as described in the Disclosure Statement, all software
used in the Business is capable of operating consistently after December 31,
1999 to accurately process data (including calculating, comparing and
sequencing) from, into and between the twentieth and twenty-first centuries,
including leap year calculations, and is otherwise currently Year 2000
compliant.

     3.13 Customers, Suppliers and Distributors. A complete list of the
purchasers and distributors of CNS Products, along with the aggregate amount
of CNS Products sold to each such customer and the aggregate amounts of CNS
Products distributed during the years ended December 31, 1998 and 1999 and
during the period from January 1, 2000 through the Closing Date is attached
to the Disclosure Statement. Except as described in the Disclosure Statement:
(a) no present customer, supplier or vendor has terminated or reduced, or has
given notice that it intends to terminate or reduce, the amount of business
done with CNS with respect to the


                                    -14-
<PAGE>

Business; (b) CNS is not aware of any such intention on the part of any such
customer, supplier or vendor, whether or not in connection with the
transactions contemplated hereunder; (c) there are no and during the last two
(2) years there have not been any disputes or controversies between CNS and
any customer, supplier or other person regarding the quality, merchantability
or safety of any products of the Business, or involving a claim of breach of
warranty which has not been fully resolved with respect to warranties
provided by CNS as to such products.

     3.14 Taxes. (a) CNS has duly and timely filed, or caused to be duly
and timely filed, all Tax Returns relating to the Business or the Assets
required to be filed by it with the appropriate Governmental Authorities, or
requests for extensions to file such Tax Returns have been timely filed and
granted and have not expired. All such Tax Returns were at the time of filing
and are as of the date hereof true, correct and complete in all material
respects relating to the Business or the Assets. All Taxes (as defined
herein) currently due and payable by CNS relating to the Business or the
Assets (whether or not shown on any Tax Return) have been paid within the
time and in the manner prescribed by law. The Financial Statements reflect
adequate reserves for all Taxes payable by CNS for all Taxable periods and
portions thereof accrued through the respective dates of such Financial
Statements. All deficiencies for any Taxes relating to the Business or the
Assets that have been proposed, asserted or assessed against CNS have been
fully paid. CNS is not a party to any pending audit, action or proceeding,
nor, to the best of CNS' knowledge, is any such audit, action or proceeding
contemplated or threatened, by any Governmental Authority for the assessment
or collection of any Taxes relating to the Business or the Assets. CNS is not
subject to any agreements, waivers or other arrangements extending the period
for assessment, levy or collection of any such Taxes. All Taxes relating to
the Business or the Assets which CNS is required by law to withhold or to
collect have been withheld or collected and paid over to the proper
Governmental Authorities or segregated and set aside for such payment.

        (b) For purposes of this Agreement, the term "Tax" (including, with
correlative meaning, the terms "Taxes" and "Taxable") means all federal,
state, local, and foreign income, profits, franchise, gross receipts,
payroll, sales, employment, use, property, withholding, excise, alternative
minimum, gains, transfer, documentary, stamp and other taxes, duties or
assessments of any nature whatsoever, together with all interest, penalties
and additions imposed with respect to such amounts, and the term "Tax
Returns" means all returns, reports, declarations, statements, elections,
forms or other documents or information required to be filed with a taxing
authority with respect to any Taxes.

     3.15 No Undisclosed Liabilities. Except as reflected on the Financial
Statements, there are no liabilities of CNS of any kind whatsoever, whether
accrued, contingent, absolute, determined, determinable or otherwise.

     3.16 Employee Benefits. The Disclosure Statement contains a complete
list of each Employee Benefit Plan (as herein defined) currently sponsored or
maintained by CNS with respect to its employees. Without limitation, the term
"Employee Benefit Plan" includes all employee welfare benefit plans within
the meaning of Section 3(1) of the Employee Retirement Income Security Act of
1974, as amended ("ERISA"), and all employee pension benefit plans within the
meaning of Section 3(2) of ERISA. Except as set forth in the Disclosure
Statement:


                                    -15-
<PAGE>

(a) each past or present Employee Benefit Plan of CNS and its ERISA Affiliates
(as defined herein) which is or was a "group health plan" has been operated
in material compliance with the continuation coverage requirements of
Section 4980B of the Code and Part 6 of Subtitle B of Title I of ERISA
("COBRA"); (b) CNS and its ERISA Affiliates neither contribute to nor have or
ever previously had any obligation under or with respect to any past or
present employee pension benefit plan which is a multiemployer plan as
defined in Section 3(37) of ERISA; (c) CNS and its ERISA Affiliates have
incurred no liability under Title IV of ERISA with respect to any past or
present employee pension benefit plan which is a multiemployer plan; (d) CNS
is and has in the past been in compliance in all material respects with ERISA
and all other applicable Laws respecting employment, employment practices,
terms and conditions of employment and wages and hours; (e) there are no
inquiries, proceedings, claims, or lawsuits which have been asserted,
instituted, or threatened by the Internal Revenue Service, the Department of
Labor, the Pension Benefit Guaranty Corporation, the Equal Employment
Opportunity Commission, or any participant, beneficiary, or other person or
entity involving any aspect of any Employee Benefit Plan (other than routine
benefit claims), nor are there any facts which could form the basis for any
such claim or lawsuit; (f) the consummation of the transactions contemplated
by this Agreement will not increase the amount of compensation due to any
Transferred Employee (as defined in Section 6.1 hereof) or entitle any
Transferred Employee to an "excess parachute payment" within the meaning of
Section 280G of the Code. There are no former employees of CNS who are
currently receiving health care coverage pursuant to COBRA and there are no
outstanding claims for health care coverage by any such employee. For
purposes of this Section 3.16, "ERISA Affiliate" shall mean any entity
required to be aggregated with CNS under Sections 414(b), 414(c), 414(m), or
414(o) of the Code and the regulations thereunder.


     3.17 Labor Matters. CNS has no collective bargaining agreements with
any union representing any of its employees, and there is not pending by any
union any formal demand for recognition or election as the collective
bargaining agent of any such employees. There has been no attempt during the
last three years by any union to organize any such employees, nor has there
been any strike, slowdown or work stoppage by any such employees during such
period. CNS has not committed in any material respect a violation of any
applicable Laws relating to labor practices. No officer or employee of CNS
has given or received notice terminating his or her employment and no such
officer or employee will be entitled to give such notice as a result of this
Agreement. To CNS' knowledge, there are no current investigations by any
Governmental Authority into any employment practice in the Business.

     3.18 Environmental Compliance.

        (a) CNS has not engaged in or permitted operations or activities
upon, or any use or occupancy of, the Exton Property or any portion thereof,
or any property owned, leased or utilized by CNS with respect to the
Business, which has resulted in the emission, release, discharge, dumping or
disposal of any Hazardous Materials on, under, in or about the Exton Property
or any property owned, leased or utilized by CNS with respect to the Business
requiring remediation under any Environmental Requirements, nor, to the
knowledge of CNS, have any Hazardous Materials migrated from the Exton Property
or any property owned, leased or utilized by CNS with respect to the Business
to, upon, about or beneath other properties requiring


                                    -16-
<PAGE>

remediation under any Environmental Requirement, nor, to the knowledge of CNS,
have any Hazardous Materials migrated from other properties to, upon, about or
beneath the Exton Property or any property owned, leased or utilized by CNS with
respect to the Business requiring remediation under any Environmental
Requirements. CNS possesses all environmental Permits required under applicable
laws to conduct the Business as presently conducted, and it has at all times
been in compliance with the terms and conditions of such Permits.

        (b) All environmental assessments, reports and investigations with
respect to any property currently or previously owned, leased, or utilized by
CNS with respect to the Business, whether commissioned by CNS or third
parties, are identified on the Disclosure Statement and have been made
available to Purchaser prior to the date hereof.

        (c) No employee, independent contractor, invitee, licensee, or, to
the knowledge of CNS, trespasser or member of the public at large, has had
his or her health impaired or threatened as a result of the operation of the
Business or as a result of the release of Hazardous Materials related to the
operation of the Business.

        (d) Except as described in the Disclosure Statement, there are no
Hazardous Materials located on, contained in or otherwise part of the Exton
Property or any other property owned, used or utilized by CNS with respect to
the Business. Except as described in the Disclosure Statement, CNS has not
arranged for the transportation, storage, treatment or disposal or any
Hazardous Materials at the Exton Property or any property owned, leased or
utilized by CNS with respect to the Business that has or could reasonably be
expected to give rise to any liability of CNS or, after the date hereof, the
Purchaser, under any Environmental Requirement.

        (e) CNS has not received notice of any claim, demand, investigation,
enforcement or other action (collectively, "Claims") instituted or threatened
against CNS by Governmental Authorities or other third parties for
Environmental Damages pursuant to any Environmental Requirements related to
the operation of the Business, any real property owned, leased or utilized by
CNS with respect to the Business, or the transportation and disposal of
Hazardous Materials by CNS at any disposal facilities off-site from the Exton
Property or at other locations not owned or leased by CNS, nor is CNS aware
of any facts, circumstances or conditions that would be reasonably likely to
give rise to a Claim for Environmental Damages.

        (f) CNS and its employees have never used the two 2,000-gallon
gasoline underground storage tanks formerly located at and removed from the
Exton Property on or about 1993.

        (g) CNS and its employees have never used any septic system located
at the Exton Property for other than personal sanitary waste purposes.

        (h) The term "Hazardous Material" means any substance which is itself
or contains "hazardous waste," "hazardous substance", pollutant or
contaminant under any federal, applicable state or local statute, regulation,
rule or ordinance or amendments thereto including, without limitation, the
Comprehensive Environmental Response, Compensation and Liability


                                    -17-
<PAGE>

Act (42 U.S.C. ss. 9601 et seq.) and/or the Resource Conservation and
Recovery Act (42 U.S.C. ss. 6901 et seq.).

        (i) The term "Environmental Requirements" means all applicable Laws,
Regulations, Permits and similar items of all Governmental Authorities and
all applicable judicial, administrative, and regulatory judgments, decrees,
orders, write or injunctions relating to the protection of human health or
the environment in each case as in effect on the Closing Date.

        (j) The term "Environmental Damages" means any and all liabilities,
losses, costs, expenses or damages of any kind whatsoever (including, without
limitation, reasonable attorneys' fees) which are incurred at any time as a
result of the presence at or prior to the Closing of any Hazardous Material
generated on the Exton Property on, under or about any other real property,
or the existence at or prior to Closing of Hazardous Material upon, about or
beneath the Exton Property or migrating to or from the Exton Property, or the
existence at or prior to the Closing of a violation of Environmental
Requirements pertaining to the Business, regardless of whether the presence
at or prior to the Closing of such Hazardous Material or violation of
Environmental Requirements arose prior to the present ownership or operation
of the Exton Property or the Business, or the existence at or prior to
Closing of any release of Hazardous Material into the environment caused or
aggravated by any transportation or disposal of Hazardous Materials by CNS at
any disposal facilities off-site from the Exton Property or at other
locations not owned or leased by CNS.

     3.19 Litigation. There are no, and during the last three (3) years
there have not been any, claims, actions, suits, proceedings (arbitration or
otherwise) or investigations involving or affecting CNS, the Business or the
Assets before or by any Governmental Authority or before an arbitrator of any
kind; and to the knowledge of CNS except as described in the Disclosure
Statement, no such claim, action, suit, proceeding or investigation is
presently threatened or contemplated and there are no facts which could
reasonably serve as the basis therefor. There are no unsatisfied judgments,
awards or penalties against CNS, the Business or the Assets.

     3.20 Employees. The Disclosure Statement sets forth the following
information for each employee of CNS engaged in the Business (including each
such person on leave or layoff status) (collectively, the "CNS Employees"):
employee name and job title; current annual rate of compensation (identifying
bonuses separately) and any change in compensation since December 31, 1998;
and vacation accrued and service credited for purposes of vesting and
eligibility to participate in applicable Employee Benefit Plans. Except as
described in the Disclosure Statement, none of the CNS Employees is a party
to, or is otherwise bound by, any agreement or arrangement with any person or
entity other than CNS which limits or adversely affects the performance of
his or her duties, the ability of CNS to conduct the Business, or his or her
freedom to engage in the Business (including, without limitation, any
confidentiality, non-competition, non-solicitation or proprietary rights
agreement). The Disclosure Statement lists each employee of CNS that has been
involuntarily terminated or forced to resign in the last three (3) years and
briefly describes the circumstances associated with such termination or
resignation. The Disclosure Statement lists or describes each employment,
severance, change of control, consulting, commission, agency and
representative agreement or arrangement relating to the


                                    -18-
<PAGE>

Business to which CNS is a party or is otherwise bound, including,
without limitation, all agreements and commitments relating to wages, hours
or other terms or conditions of employment including, but not limited to, any
oral or written agreements or promises relating to the granting of an
ownership or profit-sharing interest in the Business (other than unwritten
employment arrangements terminable at will without payment of any contractual
severance or other amount). Except as described in the Disclosure Statement,
CNS has properly classified as "employees," and has paid all required
withholding taxes with respect to, all persons who qualify as employees under
the Code and the rules and regulations promulgated thereunder.

     3.21 Absence of Changes or Events. Except as described in the
Disclosure Statement and except for actions to be taken after the date hereof
pursuant to a specific covenant hereunder, since December 31, 1998, CNS has
not, with respect to the Business:

        (a) discharged or satisfied any Lien, or paid any liabilities, other
than in the ordinary course of business, consistent with past practice, or
failed to pay or discharge when due any liabilities which the failure to pay
or discharge has caused or will cause any damage or risk of loss to the
Assets or the Business;

        (b) sold, assigned or transferred any of its assets or properties or
rights therein except in the ordinary course of business, consistent with
past practice;

        (c) created, incurred, increased, assumed or guaranteed any
indebtedness for money borrowed, or mortgaged, pledged or subjected to any
Lien, any of the Assets, other than the Liens, if any, for current taxes not
yet due and payable, or declared or paid any dividends or made any other
distributions to their shareholders;

        (d) made or suffered any amendment or termination of any Contract to
which it is a party or by which they are bound or canceled, modified or
waived any debts or claims of the Business held by them, other than in the
ordinary course of business, consistent with past practice, or waived any
right of substantial value of the Business, whether or not in the ordinary
course of business;

        (e) suffered any damage, destruction or loss, whether or not covered
by insurance, with respect to any Assets, or suffered any repeated, recurring
or prolonged shortage, cessation or interruption of supplies or utility
services required to conduct the Business;

        (f) suffered any decrease in its retained earnings or accounts
receivable resulting from the operations of the Business, or any adverse
change in the Business;

        (g) made any capital expenditure or capital addition or betterment in
respect of the Business or the Assets, except such as may be involved in
ordinary repair, maintenance and replacement of the Assets;

        (h) as it relates to the Business, made any advance (excluding
advances for ordinary and necessary business expenses) or loan to, any of its
shareholders, directors, officers, employees or independent contractors, or
made any increase in, or any addition to, other benefits


                                    -19-
<PAGE>

to which any of its shareholders, directors, officers or employees
may be entitled, or altered the terms of intercompany transactions between
CNS and Connell Neurosurgical, including without limitation the prices of
products sold by CNS to Connell Neurosurgical and terms or practices under
which payment for such products is made;

        (i) suffered any decrease in the raw materials, work-in-process or
finished goods inventory of the Business;

        (j) changed any of the accounting principles followed by it with
respect to the Business or the methods of applying such principles; or

        (k) entered into any material transaction or any transaction other
than in the ordinary course of business consistent with past practice.

     3.22 Inventory. Except as set forth in the Disclosure Statement, the
Interim Date Balance Sheet accurately reflects the finished goods inventory,
work-in-process and raw materials owned by CNS as of the date thereof. CNS'
finished goods inventory, work-in-process and raw materials are within
specifications and fit for their intended commercial use and purpose. As of
the date hereof, CNS owns at least the amount of finished goods inventory,
work-in-progress and raw materials specified in Section 8.3. Except as set
forth in the Disclosure Statement, CNS does not have any inventory that has
already been invoiced but which is not scheduled to be shipped to a customer
until following the Closing Date (commonly referred to as "bill and hold
inventory"). Except as set forth in the Disclosure Statement, the finished
goods inventory, net of reserves, is good and saleable in the ordinary course
of business, and no finished goods inventory, work-in-process or raw
materials owned by CNS has been written off or written down in the past two
(2) years, or is obsolete, slow-moving or scheduled to expire at any time
within eighteen (18) months of the date hereof.

     3.23 Accounts Receivable. All Accounts Receivable arose from bona
fide transactions in the ordinary course of the Business and are collectible
in full in the ordinary course of the Business, except to the extent of any
reserve for uncollectible Accounts Receivable included within the balance
sheet of CNS.

     3.24 Finders or Brokers. Neither CNS nor any of its affiliates have
employed any investment banker, broker, finder or intermediary in connection
with the transactions contemplated hereby who may reasonably be expected to
be entitled to a fee or any commission, directly or indirectly, from any such
person.

     3.25 Affiliate Agreements. Except as described in the Disclosure
Statement, there are no agreements, arrangements or understandings between
CNS and any present or former director, shareholder, officer or employee of
CNS or any member of the immediate family of or any person or entity
controlling or controlled by any of such persons relating to or affecting the
Business or the Assets. No such agreements, arrangements or understandings
are included in the Assets.


                                    -20-
<PAGE>

     3.26 Insurance.

        (a) The Disclosure Statement lists all policies and binders of
insurance for product liability, directors and officers, fire, liability,
property, workers' compensation and all other matters held by or on behalf of
CNS with respect to the Assets (collectively, "Insurance Policies").

        (b) CNS has not received with respect to the Business: (i) any
written notice or other notice or cancellation of any Insurance Policy or
refusal of coverage thereunder; (ii) any written notice or other notice that
any issuer of such policy has filed for protection under applicable
bankruptcy or insolvency laws or is otherwise in the process of liquidating
or has been liquidated; or (iii) any other written indication that any such
policy may no longer be in full force or effect or that the issuer of any
such policy may no longer be willing or able to perform its obligations
thereunder.

        (c) The Disclosure Statement identifies any retrospective premium
adjustments and outstanding claims or notices of claims under the insurance
policies disclosed therein.

     3.27 Export. No products of the Business that were manufactured in
the United States have been sold, directly or indirectly, in or to any of the
following countries (or to any party acting on behalf of any of the following
countries): Cuba, Libya, Iran, Iraq, North Korea, Sudan or Syria.

     3.28 Full Disclosure.

        (a) (i) all documents and other papers delivered by or on behalf of
CNS in connection with the transactions contemplated by this Agreement are
accurate, complete and authentic; and (ii) no representation or warranty of
CNS contained in this Agreement contains any untrue statement of a material
fact or omits to state a fact necessary in order to make the statements
herein or therein, in light of the circumstances under which they were made,
not misleading in any material respect.

        (b) Except as described in this Agreement or the Disclosure
Statement, there is no fact known to CNS (other than general economic or
industry conditions) which adversely affects or, so far as CNS can reasonably
foresee, threatens the Assets or the business, prospects, financial condition
or results of operations of the Business or the ability of CNS to perform
this Agreement.

                                    -21-
<PAGE>

                                  ARTICLE 4

           REPRESENTATIONS AND WARRANTIES OF CONNELL NEUROSURGICAL

Connell Neurosurgical hereby represents and warrants to the Purchaser that,
except as set forth on the Disclosure Statement (the "Disclosure Statement")
delivered to the Purchaser by Connell Neurosurgical:

     4.1 Corporate Existence. Connell Neurosurgical is a corporation duly
organized, validly existing and in good standing under the laws of its
jurisdiction of incorporation and has the requisite corporate power and
authority to own, lease and operate its properties and assets and to carry on
the CN Business as now being conducted. Connell Neurosurgical is duly
qualified to do business and is in good standing as a foreign corporation in
each jurisdiction where the conduct of the CN Business by it requires it to
be so qualified except where the failure to be so qualified would not have a
Material Adverse Effect on Connell Neurosurgical.

     4.2 Corporate Power and Authorization. Connell Neurosurgical has the
corporate power and authority to execute, deliver and perform its obligations
under this Agreement. The execution, delivery and performance of this
Agreement by Connell Neurosurgical have been duly and validly authorized by
all necessary corporate action. This Agreement has been, and the other
agreements, documents and instruments required to be delivered by Connell
Neurosurgical in accordance with the provisions hereof (collectively, the
"Connell Neurosurgical Transaction Documents", and together with the CNS
Transaction Documents, the "Seller Transaction Documents") will be, duly
executed and delivered by Connell Neurosurgical, and this Agreement
constitutes, and the Connell Neurosurgical Transaction Documents when
executed and delivered by Connell Neurosurgical will constitute, the legal,
valid and binding obligation of Connell Neurosurgical, enforceable against
Connell Neurosurgical in accordance with their respective terms, except to
the extent that enforceability may be limited by bankruptcy, insolvency,
moratorium or other similar laws presently or hereafter in effect relating to
or affecting the enforcement of creditors' rights generally and by general
principles of equity (regardless of whether enforcement is considered in a
proceeding in equity or at law).

     4.3 No Conflict.

        (a) The execution, delivery and performance of this Agreement and the
Connell Neurosurgical Transaction Documents do not and will not (with or
without the passage of time or the giving of notice):

           (i) violate or conflict with any law, regulation, permit, license,
certificate, judgment, order, award or other decision or requirement of any
arbitrator or Governmental Authority, domestic or foreign (collectively,
"Laws");

           (ii) violate or conflict with, result in a breach of, or constitute a
default or otherwise cause any loss of benefit under, any agreement or contract,
or give to others any


                                    -22-
<PAGE>

rights (including rights of termination, foreclosure, cancellation or
acceleration) in or with respect to any of the Connell Neurosurgical Assets; or

           (iii) result in, require or permit the creation or imposition of any
Lien of any nature upon or with respect to the Connell Neurosurgical Assets.

There are no judicial, administrative or other governmental actions, proceedings
or investigations pending against Connell Neurosurgical or, to the knowledge of
Connell Neurosurgical, threatened, that question any of the transactions
contemplated by, or the validity of, this Agreement or any of the other
agreements or instruments contemplated hereby or which, if adversely determined,
is likely to have an adverse effect upon the ability of Connell Neurosurgical to
enter into or perform its obligations under this Agreement or any such other
agreements or instruments. Connell Neurosurgical has not received any request
from any Governmental Authority for information with respect to the transactions
contemplated hereby.

     4.4 Compliance with Laws.

        (a) Except as described in the Disclosure Statement, the operation of
the CN Business is, and at all times during the last three (3) years has
been, in compliance in all material respects with all applicable Laws
including, without limitation, all Laws, rules and regulations prohibiting
fraud and abusive practices under federal healthcare Laws, and Connell
Neurosurgical has no basis to expect, and have not received, with respect to
the operation of the CN Business during the last three (3) years, any notice,
order or other communication from any Governmental Authority of any alleged,
actual, or potential violation of or failure to comply with any Law.

        (b) Except as described in the Disclosure Statement and except as
would not have a Material Adverse Effect, all federal, foreign, state, local
and other governmental consents, licenses, Permits, franchises, grants and
authorizations (each, an "Authorization" and collectively, "Authorizations")
required for the operation of the CN Business as currently conducted and as
conducted during the last three (3) years are in full force and effect
without any default or violation thereunder by Connell Neurosurgical or by
any other party thereto and Connell Neurosurgical has not received any notice
of any claim or charge that Connell Neurosurgical is or within the last three
(3) years has been in violation of or in default under any such
Authorization.

        (c) As to each CNS Product subject to the jurisdiction of the Food
and Drug Administration under the FDCA or the PDMA and the jurisdiction of
the Drug Enforcement Agency under the CSA which is distributed, sold and/or
marketed by Connell Neurosurgical, such product is being distributed, sold
and/or marketed in compliance in all material respects with all applicable
requirements under the FDCA, PDMA and the CSA including, but not limited to,
those relating to investigational use, premarket clearance, labeling,
promotion and advertising, record keeping, filing of reports and security.

     4.5 Books of Account. The books, records and accounts of Connell
Neurosurgical maintained with respect to the CN Business reflect all
transactions and all assets and liabilities of Connell Neurosurgical with
respect to the CN Business.



                                    -23-
<PAGE>

     4.6 Title and Sufficiency. Except as described in the Disclosure
Statement: (a) Connell Neurosurgical has, and will convey to Purchaser at
Closing, good and valid title to all of the Connell Neurosurgical Assets,
free and clear of any Liens; (b) all Connell Neurosurgical Assets owned or
leased by Connell Neurosurgical and used or held for use in the CN Business
are in the possession or under the control of Connell Neurosurgical, are
suitable for the purposes for which they are currently being used, and are of
a condition, nature and quantity sufficient for the conduct of the CN
Business as it is presently conducted; and (c) the Assets and the Excluded
Assets constitute all of the assets used in the Business and the CN Business.

     4.7 Contracts.

        (a) The Disclosure Statement contains a list of each contract (or
group of related contracts) relating to the Business or the CN Business to
which Connell Neurosurgical is a party that is not terminable at will by
Connell Neurosurgical. Connell Neurosurgical is not a party to any
distribution contracts with domestic or foreign persons, whether such
contracts are written or oral.

        (b) Except as described in the Disclosure Statement:

           (i) each contract referred to in Section 4.7(a) was made in the
ordinary course of business consistent with past practice, is in full force
and effect and is valid, binding and enforceable against the parties thereto
in accordance with its terms;

           (ii) Connell Neurosurgical has performed all obligations required to
be performed by it under each contract referred to in Section 4.7(a), and no
condition exists or event has occurred which with notice or lapse of time
would constitute a default or a basis for delay or non-performance by Connell
Neurosurgical or, to the best knowledge of Connell Neurosurgical, by any
other party thereto; and

           (iii) each other party to each contract referred to in Section 4.7(a)
has consented or been given sufficient notice (where such consent or notice
is necessary) that the same shall remain in full force and effect following
the Closing.

     4.8 Customers. A complete list of the customers that purchase CNS
Products from Connell Neurosurgical, along with the aggregate amount of CNS
Products sold to each such customer in bona fide transactions during the
years ended December 31, 1998 and 1999 and during the period from January 1,
2000 through the Closing Date, is attached to the Disclosure Statement.
Except as described in the Disclosure Statement: (a) no present customer has
terminated or reduced, or has given notice that it intends to terminate or
reduce, the amount of business done with Connell Neurosurgical with respect
to the CN Business; (b) Connell Neurosurgical is not aware of any such
intention on the part of any such customer, whether or not in connection with
the transactions contemplated hereunder; (c) there are no and during the last
two (2) years there have not been any disputes or controversies between
Connell Neurosurgical and any customer regarding the quality, merchantability
or safety of any CNS Products, or involving a claim of breach of warranty
which has not been fully resolved with respect to warranties provided by
Connell Neurosurgical as to such products.

                                    -24-
<PAGE>

     4.9 Employees. The Disclosure Statement sets forth the following
information for each employee of Connell Neurosurgical engaged in the CN
Business to whom the Purchaser or an affiliate thereof) shall offer employment
on the Closing Date pursuant to Section 7.1 hereof (collectively, the "CN
Employees"): employee name and job title; current annual rate of compensation
(identifying bonuses separately) and any change in compensation since December
31, 1998; and vacation accrued and service credited for purposes of vesting and
eligibility to participate in applicable Employee Benefit Plans. Except as
described in the Disclosure Statement, none of the CN Employees is a party to,
or is otherwise bound by, any agreement or arrangement with any person or entity
other than Connell Neurosurgical which limits or adversely affects the
performance of his or her duties, the ability of Connell Neurosurgical to
conduct the CN Business, or his or her freedom to engage in the CN Business
(including, without limitation, any confidentiality, non-competition,
non-solicitation or proprietary rights agreement). Except as described in the
Disclosure Statement, Connell Neurosurgical has properly classified as
"employees," and has paid all required withholding taxes with respect to, all CN
Employees who qualify as employees under the Code and the rules and regulations
promulgated thereunder.

     4.10 Absence of Changes or Events. Except as described in the Disclosure
Statement and except for actions to be taken after the date hereof pursuant to a
specific covenant hereunder, since December 31, 1998, Connell Neurosurgical has
not, with respect to the CN Business:

        (a) sold, assigned or transferred any of its assets or properties or
rights therein except in the ordinary course of business, consistent with
past practice;

        (b) made or suffered any amendment or termination of any CN Contract
to which it is a party or by which it is bound or waived any right of
substantial value of the CN Business;

        (c) suffered any decrease in its accounts receivable resulting from
the operations of the CN Business, or any adverse change in the CN Business;
or

        (d) changed any of the accounting principles followed by it with
respect to the CN Business or the methods of applying such principles

     4.11 Finders or Brokers. Neither Connell Neurosurgical nor any of its
affiliates have employed any investment banker, broker, finder or
intermediary in connection with the transactions contemplated hereby who may
reasonably be expected to be entitled to a fee or any commission, directly or
indirectly, from any such person.

     4.12 Full Disclosure.

        (a) Except as described in the Disclosure Statement, (i) all
documents and other papers delivered by or on behalf of Connell Neurosurgical
in connection with the transactions contemplated by this Agreement are
accurate, complete and authentic; and (ii) no representation or warranty of
Connell Neurosurgical contained in this Agreement or the Disclosure Statement
contains any untrue statement of a material fact or omits to state a fact

                                    -25-
<PAGE>

necessary in order to make the statements herein or therein, in light of the
circumstances under which they were made, not misleading in any material
respect.

        (b) Except as described in this Agreement or the Disclosure
Statement, there is no fact known to Connell Neurosurgical (other than
general economic or industry conditions) which adversely affects or, so far
as Connell Neurosurgical can reasonably foresee, threatens the Connell
Neurosurgical Assets or the CN Business or the ability of Connell
Neurosurgical to perform this Agreement.


                                  ARTICLE 5

                 REPRESENTATIONS AND WARRANTIES OF THE PURCHASER


     The Purchaser hereby represents and warrants to the Sellers that:

     5.1 Valid Existence. Purchaser is a limited liability company duly formed,
validly existing and in good standing under the laws of its jurisdiction of
formation.

     5.2 Power and Authorization. Purchaser has the power and authority to
execute, deliver and perform its obligations under this Agreement. The
execution, delivery and performance of this Agreement by Purchaser have been
duly and validly authorized by all necessary limited liability company
action. This Agreement has been, and the other agreements, documents and
instruments required to be delivered by the Purchaser in accordance with the
provisions hereof (collectively, the "Purchaser Transaction Documents") will
be, duly executed and delivered by Purchaser, and this Agreement constitutes,
and the Purchaser Transaction Documents when executed and delivered by
Purchaser will constitute, the legal, valid and binding obligation of the
Purchaser, enforceable against Purchaser in accordance with their respective
terms, except to the extent that enforceability may be limited by bankruptcy,
insolvency, moratorium or other similar laws presently or hereafter in effect
relating to or affecting the enforcement of creditors' rights generally and
by general principles of equity (regardless of whether enforcement is
considered in a proceeding in equity or at law).

     5.3 No Conflict.

        (a) The execution, delivery and performance of this Agreement and the
Purchaser Transaction Documents do not and will not (with or without the
passage of time or the giving of notice): (i) violate or conflict with any
provision of Purchaser's Certificate of Formation, operating agreement or of
any Law binding upon Purchaser; or (ii) violate or conflict with, result in a
breach of, or constitute a default or otherwise cause any loss of benefit
under any material agreement or other material obligation to which Purchaser
is a party; other than such violations, conflicts, breaches, defaults or
losses which would not be likely to have a Material Adverse Effect on
Purchaser's ability to enter into or perform its obligations under this
Agreement and the Purchaser Transaction Documents.

                                    -26-
<PAGE>

        (b) No consents or approvals of, or registrations, notifications,
filings and/or declarations with, any Governmental Authority, creditor,
lessor or other person are required to be given or made by Purchaser in
connection with the execution, delivery and performance by Purchaser of this
Agreement and the other Purchaser Transaction Documents, other than such as
have been obtained or made or which the failure to obtain would not be likely
to have an adverse affect on Purchaser's ability to enter into or perform its
obligations under this Agreement and the other Purchaser Transaction
Documents.

        (c) There are no judicial, administrative or other governmental
actions, proceedings or investigations pending or, to the knowledge of
Purchaser, threatened, that question any of the transactions contemplated by
this Agreement or the validity of this Agreement or any of the other
Purchaser Transaction Documents or which, if adversely determined, would be
likely to have an adverse effect upon the ability of Purchaser to enter into
or perform its obligations under this Agreement and the other Purchaser
Transaction Documents.

     5.4 Brokers. Neither Purchaser nor any of its affiliates have employed any
investment banker, broker, finder or intermediary in connection with the
transactions contemplated hereby who may reasonably be expected to be entitled
to a fee or any commission, directly or indirectly, from any such person.

     5.5 Litigation. No action, suit, claim, investigation, administrative
proceeding, arbitration or other proceeding of or before any arbitrator or
Governmental Authority is pending or, to the best of the Purchaser's knowledge,
threatened against Purchaser which challenges or seeks to prevent, enjoin, alter
or delay the transactions contemplated hereby.

     5.6 SEC Reports.

        (a) Since January 1, 1999, Integra LifeSciences Holdings Corporation
("Integra Holdings") has timely filed all forms, reports, statements and
other documents required to be filed with (1) the Securities and Exchange
Commission (the "SEC"), including without limitation (A) all Annual Reports
on Form 10-K, (B) all Quarterly Reports on Form 10-Q, (C) all proxy
statements relating to meetings of stockholders (whether annual or special),
(D) all Current Reports on Form 8-K and (E) all other reports, schedules,
registration statements or other documents (collectively referred to as the
"Integra Holdings SEC Reports"), and (b) any applicable state securities
authorities, except where the failure to file any such forms, reports,
statements or other documents could not reasonably be expected to have a
materially adverse effect on the financial condition, results of operations,
business or prospects of Buyer and its subsidiaries, taken as a whole. The
Integra Holdings SEC Reports were prepared in all material respects in
accordance with the requirements of applicable Law (including the Securities
Act of 1933, as amended, and the Securities Exchange Act of 1934, as amended,
as the case may be, and the rules and regulations of the SEC thereunder
applicable to such Integra Holdings SEC Reports) and the Integra Holdings SEC
Reports did not at the time they were filed contain any untrue statement of a
material fact or omit to state a material fact required to be stated therein
or necessary in order to make the statements therein, in the light of the
circumstances under which they were made, not misleading in any material
respect.

                                    -27-
<PAGE>

        (b) Each of the consolidated financial statements (including, in each
case, any related notes thereto) contained in the Integra Holdings SEC
Reports (i) have been prepared in accordance with the published rules and
regulations of the SEC and generally accepted accounting principles applied
on a consistent basis throughout the periods involved (except (A) to the
extent disclosed therein or required by changes in generally accepted
accounting principles, (B) with respect to Integra Holdings SEC Reports filed
prior to the date of this Agreement, as may be indicated in the notes thereto
and (C) in the case of the unaudited financial statements, as permitted by
the rules and regulations of the SEC) and (ii) fairly present the
consolidated financial position of Integra and its subsidiaries as of the
respective dates thereof and the consolidated results of operations and cash
flows for the periods indicated (subject, in the case of unaudited
consolidated financial statements for interim periods, to adjustments,
consisting only of normal, recurring accruals, necessary to present fairly
such results of operations and cash flows), except that any pro forma
financial statements contained in such consolidated financial statements are
not necessarily indicative of the consolidated financial position of Integra
Holdings and its subsidiaries as of the respective dates thereof and the
consolidated results of operations and cash flows for the periods indicated.


                                  ARTICLE 6

                          AGREEMENTS PENDING CLOSING

     6.1 Agreements of Sellers Pending the Closing. Except as expressly
provided herein, between the date hereof and the Closing, unless otherwise
consented to in writing by the Purchaser, each of CNS and Connell
Neurosurgical shall with respect to the Business:

        (a) carry on the Business in the usual, regular and ordinary course
in substantially the same manner as heretofore conducted and use its best
efforts to maintain the present business organization and goodwill, keep
available the services of present employees and preserve relationships with
customers, suppliers and others having dealings with the Business;

        (b) refrain from making or initiating any unusual or new methods of
manufacture, purchase, sale, shipment or delivery, lease, management,
accounting or operation or shipping or delivering any quantity of products in
excess of normal shipment or delivery levels, and make no sales or other
dispositions of Assets other than sales in the ordinary course of business;

        (c) perform each obligation (for which there are no reasonable
grounds for contest) under agreements affecting the Assets or Business;

        (d) maintain the books of account and records concerning the Assets
and the Business in the regular manner consistent with past practices;

        (e) maintain the tangible Assets in good working order and condition,
reasonable wear and tear excepted;

                                    -28-
<PAGE>

        (f) continue in effect all insurance of the Business including,
without limitation, the Insurance Policies, at not less than the current
coverage levels thereof;

        (g) use reasonable efforts not to take any action which would result
in a breach of any of their representations and warranties contained in this
Agreement, and the Sellers shall cooperate with the Purchaser and use
reasonable efforts to cause all of the conditions to the obligations of the
Purchaser and the Sellers under this Agreement to be satisfied on or prior to
the Closing Date;

        (h) pay and distribute to its Employees (i) all wages in accordance
with its usual and customary payroll schedule, and (ii) all Christmas,
end-of-year and other bonuses and special payments relating to work performed
on or before the Closing Date;

        (i) except in the ordinary course of business, consistent with past
practice and the representations and warranties of CNS contained in this
Agreement, not enter into any other agreements, commitments, contracts or
undertakings relating to the Business or the Assets; and

        (j) not enter into any compromise or settlement of any litigation,
action, suit, claim, proceeding or investigation relating to the Business or
the Assets.

     6.2 Negative Covenants. Except as expressly provided herein, between
the date hereof and the Closing, unless otherwise consented to in writing by
the Purchaser, neither CNS nor Connell Neurosurgical shall (1) create, cause,
incur or permit the imposition or attachment of any Lien on any of the
Assets, the Business, CNS or Connell Neurosurgical, except for Liens for
property Taxes not yet due and payable; (2) sell, assign, transfer, abandon
or otherwise dispose of any of the Assets, or any interest therein, other
than with respect to sales of inventory in the ordinary course of business,
consistent with past practice; (3) merge or consolidate with any corporation,
partnership, association or other business organization or division thereof;
(4) modify, amend, alter, waive or terminate any of the Contracts described
in Schedule 1.1(e) or any of the CN Contracts described in Schedule 1.2(c) or
any right or interest it has thereunder, or modify, amend, alter, waive or
terminate any affiliate transaction, including the prices of products sold by
CNS to Connell Neurosurgical or the terms of practice of payment of any
intercompany accounts receivable; (5) take any action to amend its charter or
bylaws or other governing documents; (6) issue any stock, bonds, shares of
its capital or other securities or grant any option or issue any warrant to
purchase or subscribe for any of such securities or issue any securities
convertible into or exchangeable for such securities; (7) incur any
obligation or liability (absolute or contingent), except current liabilities
incurred and obligations under contracts entered into in the ordinary course
of the business consistent with past practice; (8) cancel any debts or
claims, except in the ordinary course of business, consistent with past
practice; (9) make, accrue or become liable for any bonus, profit sharing or
incentive payment, except for accruals under existing Employee Benefit Plans,
if any, or increase the rate of compensation payable or to become payable by
it to any of its officers, directors or employees, other than increases in
the ordinary course of the business consistent with past practice; (10) make
any election to give any consent under the Code or the Tax statutes of any
state or other jurisdiction or make any termination, revocation or
cancellation of any such election or any consent or compromise or settle any
claim for past or present tax due; (11) waive any rights of


                                    -29-
<PAGE>

material value; (12) make or permit any act or omission constituting
a breach or default under any contract, indenture or agreement by which it or
its properties are bound; (13) enter into any leases, contracts, agreements
or understandings other than those entered into in the ordinary course of
business, consistent with past practice; (14) hire or engage any employee or
independent contractor; (15) alter the terms, status or funding condition of
any Employee Benefit Plan, or establish or create any Employee Benefit Plan;
or (16) commit or agree to do any of the foregoing in the future.

     6.3 Transfer of Inventory. On or prior to Closing, Connell
Neurosurgical shall transfer or cause to be transferred its entire inventory
of CNS Products to CNS.

     6.4 Agreements of the Sellers Pending the Closing. Except as
expressly provided herein, between the date hereof and the Closing, unless
otherwise consented to in writing by the Purchaser, each Seller shall use
reasonable efforts not to take any action which would result in a breach of
any of its representations and warranties contained in this Agreement.

     6.5 Access to Information; Confidentiality. Prior to the Closing, CNS
shall give Purchaser and its authorized representatives complete access to
all of its personnel, books, records, plants, offices and other facilities
and properties relating to the Business and permit Purchaser to make such
inspections thereof as Purchaser may request, and cause their officers,
employees and advisors to furnish Purchaser with such financial, operating
and other information regarding the Business, and all agreements,
commitments, liabilities, personnel and properties relating to the Business
as Purchaser may request. Prior to the Closing, Connell Neurosurgical shall
give Purchaser and its authorized representatives complete access to all of
its personnel that work in the Business and to its books, records and
customer lists relating to the Assets and the Business. Purchaser
acknowledges that certain of the information which may be made available to
it is proprietary and includes confidential information. Purchaser shall use
such information only in connection with the transactions contemplated
hereunder, shall hold all such information in confidence and shall not
disclose it to any person before the Closing (or at any time if this
Agreement fails to close) without the approval of Sellers; provided, however,
that the foregoing restriction shall not apply to any information which is or
becomes publicly known or which is lawfully obtained from a third party or to
any disclosure required by law or in connection with the enforcement of
Purchaser's rights under this Agreement or any Transaction Document. If the
transactions contemplated hereby are not consummated, Purchaser shall return
to CNS all documents containing proprietary information. Sellers shall hold
in confidence and shall return all confidential or proprietary information
pertaining to Purchaser (or any of its affiliates) which may be made
available to Sellers to the same extent as set forth above with respect to
proprietary information regarding Sellers.

     6.6 Best Efforts. Prior to the Closing, each party hereto shall use
best efforts to cause to occur the transactions contemplated hereby and to
cause all conditions to the performance of the parties hereto that are within
its control to be satisfied.

     6.7 Consents, Approvals, etc. Prior to the Closing, CNS shall obtain
(and cooperate with Purchaser in obtaining) all Consents, Permits,
Authorizations, approvals of, and exemptions by, any regulatory or other
Governmental Authority necessary for the consummation of the


                                    -30-
<PAGE>

transactions contemplated herein and shall use its best efforts to
obtain such third party Consents to such transactions (including, without
limitation, the sale, transfer and/or assignment of the Assets and Contracts)
as Purchaser reasonably may request.

     6.8 Notice of Purchase and Sale of Assets. Sellers shall provide the
Pennsylvania Department of Revenue with written notice of the purchase and
sale of the Assets at least ten (10) days prior to the Closing Date in
accordance with 72 P.S. Section 7240.



                                  ARTICLE 7

                       EMPLOYEE BENEFITS AND EMPLOYMENT

     7.1 Employment.

        (a) The Disclosure Statement contains a list of all CNS Employees and
CN Employees (collectively, the "Employees"), and provides each such person's
full name, title and hourly wage or salary as of the date hereof.

        (b) The Disclosure Statement also contains a list of the names of
those Employees to whom Purchaser (or an affiliate thereof) shall offer
employment on the Closing Date. Each of the Sellers hereby agrees not to
induce any Employees who receive offers of employment from Purchaser to
decline such offer. Purchaser shall not be obligated to offer employment to
any persons not specifically identified on the Disclosure Statement as being
an intended recipient of an offer of employment from Purchaser on the Closing
date. Employees who are offered, if any, and accept such employment shall be
referred to as "Transferred Employees" for purposes of this Agreement. CNS
shall be responsible for any severance pay obligations with respect to
individuals employed in the Business who are not Transferred Employees and
whose employment with CNS is terminated. Anything contained in or implied by
the provisions of this Section 7.1 to the contrary notwithstanding, the
provisions of this Section shall not create any third-party beneficiary
rights in any person, including any Transferred Employee.

     7.2 Employee Benefit Plans. Purchaser assumes no responsibility with
respect to any Employee Benefit Plan, except as provided in Section 7.3.

     7.3 Health Care Continuation Coverage. CNS shall be responsible for
all health continuation coverage requirements of the Code and ERISA for all
periods prior to the Closing Date, and shall also be responsible for all
health care continuation coverage requirements on and after the Closing Date
for all Employees and other qualified beneficiaries (within the meaning of
Section 4980B(g)(1) of the Code) other than Transferred Employees (and their
spouses and dependents). Purchaser shall be responsible for all health care
continuation coverage requirements of the Code and ERISA for Transferred
Employees (and their spouses and dependents) for all periods subsequent to
the Closing Date.

                                    -31-
<PAGE>

     7.4 Reporting and Disclosure Requirements. CNS shall be responsible for
filing all annual reports and satisfying all other reporting and disclosure
requirements with respect to any Employee Benefit Plan.

     7.5 Employee Records. CNS and Connell Neurosurgical shall grant
Purchaser full access to all employee records relating to the Transferred
Employees.

     7.6 401(k) Accounts. Sellers shall adopt, or cause to be adopted, such
resolutions as may be necessary to terminate the Surgical Sales Corporation
401(k) Profit Sharing Plan & Trust ("Qualified Plan") as of a date no later
than the day prior to the Closing Date ("Termination Date"). Such resolutions
shall further provide that the Qualified Plan be amended to cease all future
contributions and benefit accruals under the Qualified Plan as of the
Termination Date and vest all participants thereunder as of the Termination
Date. In addition, such resolutions shall provide that the termination of the
Qualified Plan shall be subject to the condition subsequent that the Internal
Revenue Service determines that the termination of the Qualified Plan will
not adversely affect its qualified status under Code ss.401(a) and that CNS
shall make such submission as may be necessary to obtain such determination.
The resolutions shall also direct the liquidation and termination of the
trust established under the Qualified Plan upon receipt of a favorable
determination with respect to the termination of the Qualified Plan. Sellers
shall also cause CNS to adopt amendments to the Qualified Plan to the extent
necessary to implement the resolutions, such amendments to be effective
subject to the condition subsequent of the determination by the Internal
Revenue Service that such amendment(s) will not adversely affect the
qualified status of the Qualified Plan under Code ss.401(a). Sellers shall
cause CNS to prepare and file a submission to the Internal Revenue Service
requesting a determination that the amendments adopted pursuant to this
section do not adversely affect the qualification of the Qualified Plan under
Code ss.401(a).


                                  ARTICLE 8

           CERTAIN CONDITIONS PRECEDENT TO PURCHASER'S OBLIGATIONS

     The obligation of Purchaser to consummate the acquisition of the Assets
is subject to the fulfillment by or at the Closing of each of the following
conditions:

     8.1 Representations and Warranties. The representations and warranties
of Sellers contained in this Agreement shall be deemed to have been made
again at and as at the time of Closing as though originally made at and as at
the time of Closing and shall then be true and correct as though originally
made at and as at the time of Closing.

     8.2 Performance of Covenants. Sellers shall have performed or complied
in all material respects with all of the agreements, covenants and conditions
required by this Agreement to be performed or complied with by them prior to
or at the Closing.

     8.3 Financial Position. On the Closing Date, CNS shall have finished
goods inventory, raw materials, and work-in-progress at least equal to
$520,000 in value, prepaid


                                    -32-
<PAGE>

expenses of at least $14,000, and accounts payable and Assumed Liabilities of
no more than $30,000. Purchaser shall have received a certificate signed
by the President of CNS, dated the Closing Date, certifying in such detail as
Purchaser may reasonably request that the conditions specified in this
Section 8.3 have been fulfilled.

     8.4 Consents, Approvals, etc.. The requisite approval of the holders of
voting securities of CNS and of the Board of Directors of each of Sellers for
the transactions contemplated herein shall have been obtained. Further, the
Consents, approvals, Permits, Authorizations and exemptions provided for in
Section 1.8 hereof shall have been obtained and no such consent or approval:
(a) shall have been conditioned upon the material adverse modification,
cancellation or termination of any commitment, agreement, right or
Authorization included in the Assets; or (b) shall impose on the Purchaser
any condition, provision or requirement not presently imposed upon Sellers or
any condition that would be more restrictive after the Closing on Purchaser
than the conditions presently imposed on Sellers.

     8.5 Legal Matters. The Closing shall not violate any order or decree of
any court or governmental body of competent jurisdiction, and no suit,
action, proceeding or investigation shall be pending or threatened by any
person (other than the Purchaser or an affiliate of Purchaser) which
questions the validity or legality of this Agreement or the transactions
contemplated hereby.

     8.6 No Material Adverse Change. There shall not have been any material
adverse change, or threat of material adverse change, in the Business, the
Assets or the financial condition, results of operations or prospects of CNS.

     8.7 Opinion of Counsel. Purchaser shall have received the Sellers'
Opinion.

     8.8 Closing Certificate. Purchaser shall have received a certificate
signed by the President of each Seller, dated the Closing Date, certifying in
such detail as Purchaser may reasonably request that the conditions specified
in Sections 8.1 and 8.2 hereof have been fulfilled.

     8.9 Consulting Agreement. George J. Connell shall have executed and
delivered a Consulting Agreement, substantially in the form of Exhibit F
attached hereto (the "Consulting Agreement").

     8.10 Closing Deliveries. Sellers shall have made all closing deliveries
specified in Section 2.2(a).


                                  ARTICLE 9

           CERTAIN CONDITIONS PRECEDENT TO OBLIGATIONS OF SELLERS.

     The obligation of Sellers to consummate the sale of the Assets is
subject to the fulfillment by or at the Closing of each of the following
conditions:

                                    -33-
<PAGE>

     9.1 Representations and Warranties. Purchaser's representations and
warranties contained in this Agreement shall be deemed to have been made
again at and as at the time of Closing as though originally made at and as at
the time of Closing and shall then be true and correct as though originally
made at and as at the time of Closing.

     9.2 Performance of Covenants. Purchaser shall have performed or complied
in all material respects with all of the agreements, covenants and conditions
required by this Agreement to be performed or complied with by it prior to or
at the Closing.

     9.3 Approvals. All consents and approvals of any Governmental Authority
necessary for the transactions contemplated herein shall have been obtained.

     9.4 Legal Matters. The Closing shall not violate any order or decree of
any court or governmental body of competent jurisdiction and no suit, action,
investigation, or legal or administrative proceeding shall have been brought
or threatened by any person (other than Sellers) which questions the validity
or legality of this Agreement or the transactions contemplated hereby.

     9.5 Closing Certificate. Sellers shall have received a certificate
signed by an executive officer of Purchaser or an executive officer of the
sole member of Purchaser, dated the Closing Date, certifying in such detail
as Sellers may reasonably request that the conditions specified in Sections
9.1 and 9.2 hereof have been fulfilled.

     9.6 Consulting Agreement. Purchaser shall have executed and delivered
the Consulting Agreement.

     9.7 Closing Deliveries. Purchaser shall have made all closing deliveries
specified in Section 2.2(b).


                                 ARTICLE 10

                   CERTAIN POST-CLOSING MATTERS; COVENANTS

     10.1 Confidential Information. From and after the Closing, unless
expressly consented to in writing by Purchaser, neither Seller nor George J.
Connell shall, directly or indirectly, use or disclose to any third person
any trade secret, financial data, customer list, pricing or marketing
policies or plans or other proprietary or confidential information relating
to the Business.

     10.2 Covenant Not to Compete. Except as permitted in Section 10.9
hereof, each of the Sellers and George J. Connell agrees that, unless acting
with the prior written consent of Purchaser, which consent may be granted or
denied in the sole discretion of Purchaser neither Seller nor George J.
Connell nor any of their respective affiliates will, directly or indirectly,
for a period of three (3) years after the Closing Date (the "Noncompete
Period") anywhere in the United States or in any other country, directly or
indirectly:

                                    -34-
<PAGE>

        (a) (i) own, manage, operate, control, consult with, participate in, or
be connected in any manner with the ownership, management, operation, or
control of any business which engages, directly or indirectly, in the
marketing, sale or distribution of any of the following (collectively, the
"Protected Products"): (A) any medical device for treating central nervous
system (i.e., brain and spine) pathologies that is used in hospital intensive
care units, neuro-intensive care units or emergency rooms; or (B) any
products used for cranial access, management of intracranial hypertension,
drainage of cerebrospinal fluid and any products related thereto, including,
without limitation, catheters, sensors and drainage systems; (ii) be or
become a stockholder, partner, owner, agent of, or a consultant to or give
financial or other assistance to, any person or entity considering engaging
in any such activities or so engaged; (iii) seek in competition with the
business of Purchaser or any affiliate of Purchaser to procure orders for
Protected Products from or do business with any customer of Purchaser or any
affiliate of Purchaser with respect to Protected Products; (iv) solicit, or
contact with a view to the engagement or employment by, any Transferred
Employee or person or entity of any person who is an employee or contractor
of Purchaser or any affiliate of Purchaser; (v) seek to contract with or
engage (in such a way as to adversely affect or interfere with the business
of Purchaser or any affiliate of Purchaser) any person or entity who has been
contracted with or engaged to manufacture, assemble, supply or deliver
Protected Products; or (vi) engage in or participate in any effort or act to
induce any of the customers, associates, consultants, or employees of
Purchaser or any affiliate of Purchaser (including without limitation any
Transferred Employee) to take any action which is disadvantageous to
Purchaser or any affiliate of Purchaser; and

        (b) contact, induce, solicit or influence any client of the Business or
of the Purchaser or any of its affiliates to cause such client to terminate
or reduce in any material way its relationship with the Business and/or
Purchaser.

     In the event that the provisions of this Section 10.2 should ever be
deemed to exceed the time or geographic limitations or any other limitations
permitted by applicable law in any jurisdiction, then such provisions shall
be deemed reformed in such jurisdiction to the maximum permitted by
applicable law. Each of Sellers and George J. Connell specifically
acknowledges and agrees that the foregoing restrictions are reasonable and
necessary to protect the legitimate interests of Purchaser, that Purchaser
would not have entered into this Agreement in the absence of such
restrictions, that any violation of such restrictions will result in
irreparable injury to the Purchaser, that the remedy at law for any breach of
the foregoing restrictions will be inadequate, and that, in the event of any
such breach, the Purchaser, in addition to any other relief available to it,
shall be entitled to temporary injunctive relief before trial from any court
of competent jurisdiction as a matter of course and to permanent injunctive
relief without the necessity of quantifying actual damages.

     10.3 Assets, Authorizations, etc. Sellers shall use their best efforts
to take, or cause to be taken, such action, to execute and deliver, or cause
to be executed and delivered, such additional documents and instruments and
to do, or cause to be done, all things necessary, proper or advisable under
the provisions of this Agreement and under applicable law (a) to transfer any
Intellectual Property and other Contracts and Assets referred to in Section
1.1 hereof to Purchaser and otherwise to evidence and effectuate the
transactions contemplated in this


                                    -35-
<PAGE>

Agreement, and (b) at the expense of Purchaser, to permit the Purchaser to
promptly obtain all governmental consents, licenses, Permits, franchises, grants
or other Authorizations which are used in the operation of Business and are
required for the Business and operations of the Purchaser after the Closing.

     10.4 Use of Name. Immediately following the Closing, CNS shall
officially change its name to a name not containing the names "CNS" or
"Clinical Neuro Systems, Inc." or any similar sounding name or any variant
thereof and neither Seller nor George J. Connell nor any of their respective
affiliates shall thereafter use for any purpose the names "CNS" or "Clinical
Neuro Systems, Inc." or any similar sounding name. Connell Neurosurgical (a)
may retain and continue to use the names "Connell Neurosurgical" and
"Surgical Sales Corporation" notwithstanding this Section 10.4, and (b)
agrees that Purchaser may use or sell any products, inventory, supplies,
parts or marketing materials conveyed to Purchaser as part of the Assets
notwithstanding the fact that certain of such products, inventory, supplies,
parts or marketing materials may have affixed to them labels or other marks
bearing a name or names not included in the Assets.

     10.5 Satisfaction of Obligations. After the Closing, CNS shall satisfy
any and all of its liabilities and obligations which have not been expressly
assumed by Purchaser under this Agreement.

     10.6 Property Received. After the Closing Date, Sellers, on the one
hand, and Purchaser and CNS, on the other hand, shall promptly transfer and
deliver to the other, from time to time as and when received by it, any cash,
checks with appropriate endorsements (using their reasonable efforts not to
convert such checks into cash), or other property that such party may receive
on or after the Closing which properly belongs to the other party and will
account to the other for all such receipts.

     10.7 Preserve Value of Business. After the Closing Date, Sellers shall,
from time to time and without further consideration, use their best efforts
to take such actions and execute such instruments and documents as are
reasonably requested by Purchaser to preserve the value of and goodwill
associated with the Business, the CN Business and the Assets.

     10.8 Payment of Intercompany Receivables. Within thirty (30) days
following the Closing Date, CNS shall pay or cause to be paid to Purchaser an
amount in cash equal to all accounts receivable owing from Connell
Neurosurgical to CNS as of the Closing Date, and CNS hereby covenants to take
all further actions and execute all further instruments and documents to
effect such payment of intercompany receivables to Purchaser.

     10.9 Permitted Development; Integra Right of First Offer.

        (a) Notwithstanding anything in this Agreement to the contrary, George
J. Connell may continue to develop an implantable intracranial pressure
transducer, which measures intracranial pressure by telemetrically
transmitting data on a continuous basis to a hand-held monitor (the
"Telemetric Pressure Transducer").

                                    -36-
<PAGE>

        (b) Neither George J. Connell nor any affiliate thereof including,
without limitation, Connell Neurosurgical or CNS, shall enter into any
agreement, understanding or other arrangement, whether written or oral, with
a third party with respect to the commercial re-sale, distribution or
marketing of the Telemetric Pressure Transducer at any time during the
Noncompete Period unless he or it first offers to Integra the exclusive,
worldwide right to re-sell, market and distribute the Telemetric Pressure
Transducer on commercially reasonable terms. Such offer must be submitted in
writing to Integra and Integra shall have forty-five (45) days from the
receipt of such offer to accept or reject such offer. In the event Integra
expressly rejects such offer, George J. Connell, Connell Neurosurgical or
CNS, as the case may be, may discuss or negotiate with any third party for
the right to re-sell, distribute or market the Telemetric Pressure Transducer
to any third party, provided that neither George J. Connell, Connell
Neurosurgical or CNS, nor any affiliate of any of the foregoing, may enter
into any agreement with any third party with respect to the Telemetric
Pressure Transducer on terms that are more favorable to the third party than
the terms offered to Integra.

     10.10 Payroll Filings. The parties agree to follow the "alternate
procedure" specified in Revenue Procedure 96-60, 1996-2 C.B. 399, Section 5
whereby for the calendar year in which the Closing Date occurs, among other
things, Purchaser will be responsible for the Form W-2 reporting duties with
respect to the payment of wages and other compensation (at any time during
such calendar year) to employees that are hired by Purchaser, and Sellers
will each be responsible for the Form W-2 reporting duties with respect to
its own payment of wages to employees that are not hired by Purchaser.
Sellers will cooperate in furnishing any information required by Purchaser to
prepare such Forms W-2 to the extent that they cover pre-Closing periods.

                                 ARTICLE 11

                               INDEMNIFICATION

     11.1 Indemnification by Sellers. Each of George J. Connell and Sellers,
jointly and severally, shall indemnify and hold Purchaser and Purchaser's
officers, directors, employees and shareholders (collectively, "Purchaser
Indemnified Parties") harmless against and in respect of any and all losses,
costs, expenses, claims, damages, obligations and liabilities (whether known
or unknown, whether asserted or unasserted, whether absolute or contingent,
whether accrued or unaccrued, whether liquidated or unliquidated, and whether
due or to become due), including costs of investigation and interest,
penalties and reasonable attorneys' fees and disbursements ("Damages"), net
of any proceeds from insurance or any other collateral source, which any
Purchaser Indemnified Party may suffer, incur or become subject to arising
out of, based upon or otherwise in respect of: (a) any inaccuracy in or
breach of any representation or warranty of either Seller made in or pursuant
to this Agreement or any Seller Transaction Document; (b) any breach or
nonfulfillment of any covenant or obligation of either Seller or George J.
Connell contained in this Agreement or any Seller Transaction Document; (c)
any finder's or broker's fee due or claimed to be due by reason of any third
party acting on Sellers' behalf in connection with the transactions
contemplated by this Agreement; (d) any liability or other obligation of
either Seller other than the Assumed Liabilities; and (e) any matters
referenced in Sections 3.4, 3.8(e) and 3.19 of the Disclosure Statement.



                                    -37-
<PAGE>

     11.2 Indemnification by Purchaser. Purchaser shall indemnify and hold
each Seller and each officer, director and shareholder of each Seller
(collectively, "Seller Indemnified Parties") harmless against and in respect
of any and all Damages which any Seller Indemnified Party may suffer, incur
or become subject to arising out of, based upon or otherwise in respect of:
(a) any inaccuracy in or breach of any representation or warranty of
Purchaser made in or pursuant to this Agreement or any Purchaser Transaction
Document; (b) any breach or nonfulfillment of any covenant or obligation of
Purchaser contained in this Agreement or any Purchaser Transaction Document;
(c) any finder's or broker's fee due or claimed to be due by reason of any
third party acting on Purchaser's behalf in connection with the transactions
contemplated by this Agreement; and (d) the Assumed Liabilities.

     11.3 Inter-Party Claims. Any party seeking indemnification pursuant to
this Section 11 (the "Indemnified Party") shall notify the other party or
parties from whom such indemnification is sought (the "Indemnifying Party")
of the Indemnified Party's assertion of such claim for indemnification,
specifying the basis of such claim. The Indemnified Party shall thereupon
give the Indemnifying Party reasonable access to the books, records and
assets of the Indemnified Party which evidence or support such claim or the
act, omission or occurrence giving rise to such claim and the right, upon
prior notice during normal business hours, to interview any appropriate
personnel of the Indemnified Party related thereto.

     11.4 Third Party Claims.

        (a) Each Indemnified Party shall promptly notify the Indemnifying Party
of the assertion by any third party of any claim with respect to which the
indemnification set forth in this Section relates (which shall also
constitute the notice required by Section 11.3). The failure by an
Indemnified Party to notify an Indemnifying Party of a third party claim will
not relieve the Indemnifying Party of any indemnification responsibility
under this Article 11, except to the extent, if any, that such failure
materially prejudices the ability of the Indemnifying Party to defend such
third party claim The Indemnifying Party shall have the right, upon notice to
the Indemnified Party within fifteen (15) days after the receipt of any such
notice, to undertake the defense of or, with the consent of the Indemnified
Party, to settle or compromise such claim; provided that, without the
Indemnified Party's consent (which shall not be unreasonably withheld), the
Indemnifying Party shall not consent to the entry of any judgment or enter
into any settlement that provides for injunctive or other non-monetary relief
affecting the Indemnified Party. In its defense, compromise or settlement of
any third party claim, the Indemnifying Party will timely provide the
Indemnified Party with such information with respect to such defense,
compromise or settlement as the Indemnified Party may reasonably request. The
failure of the Indemnifying Party to give notice and to undertake the defense
of or to settle or compromise a third party claim shall constitute a waiver
of the Indemnifying Party's rights under this Section 11.4(a) and shall
preclude the Indemnifying Party from disputing the manner in which the
Indemnified Party may conduct the defense of such claim or the reasonableness
of any amount paid by the Indemnified Party in satisfaction or settlement of
such claim.

        (b) The election by the Indemnifying Party, pursuant to Section 11.4(a),
to undertake the defense of a third-party claim shall not preclude the party
against which such claim


                                    -38-
<PAGE>

has been made also from participating or continuing to participate in such
defense, so long as such party bears its own legal fees and expenses for
so doing.

     11.5 Right of Set-Off. Purchaser shall have the right to set-off against
the outstanding principal amount or interest which may be owed by Purchaser
pursuant to the Note any Damages incurred by any Purchaser Indemnified Party
under Section 11.1 of this Agreement, subject to the limitations set forth in
Section 11.6. The exercise of such right of set-off by Purchaser shall not
constitute an event of default under any obligation of Purchaser.


     11.6 Limitations.

        (a) Any claim for indemnification for any inaccuracy or breach of a
representation, warranty or covenant under this Article 11 must be made by
giving written notice of such claim to the party from whom indemnity is
sought not later than the expiration of the Survival Period (as defined in
Section 13.2 herein).

        (b) The primary remedy for any claim by Purchaser for indemnification
under this Article 11 shall be the right of set-off set forth in Section 11.5
hereof and Section 9 of the Note; provided, however, that if the aggregate
amount for which Purchaser seeks to be indemnified exceeds the principal
amount of the Note outstanding at the time of such claim or if the Note has
been satisfied in full prior to the time of such claim, then Purchaser shall
have the right to pursue any other remedies available at law or under this
Agreement in respect of such claim for indemnification, including the right
to seek indemnification from any person or entity that then holds any
proceeds of the Note.

        (c) Neither Seller nor George J. Connell shall have any obligation to
indemnify any Purchaser Indemnified Party against Damages pursuant to Section
11.1 (a) arising out of or based upon any inaccuracy in or breach of any
representation or warranty made in or pursuant to this Agreement or any
Seller Transaction Document unless and until the aggregate of all such
Damages suffered or incurred by the Purchaser Indemnified Parties exceeds
$37,500 and then only to the extent such Damages exceed $37,500; provided,
however, that the above limitation shall not be applicable to any claim for
Damages pursuant to Sections 10.1(b), (c) or (d) hereof or based upon an
inaccuracy in or breach of any representation or warranty made in or pursuant
to Sections 3.1, 3.2, 3.7(a), 3.14, 3.15, 3.16, 3.24, 4.1, 4.2, 4.6(a) or
4.11 hereof.

        (d) The cumulative maximum amount of Damages for which any party may be
liable under this Article 11 for a breach of a representation or warranty
shall be $1,400,000.

        (e) The Purchaser Indemnified Parties shall have no obligation to seek
to minimize, reduce or otherwise mitigate, through the filing of a claim
under any applicable insurance policy or otherwise, any Damages suffered or
incurred by the Purchaser Indemnified Parties.

                                    -39-
<PAGE>

                                 ARTICLE 12

                                 TERMINATION

     12.1 Termination. This Agreement may be terminated and the transactions
contemplated herein may be abandoned at any time prior to the Closing:

        (a) by Purchaser or Sellers if the Closing has not occurred by January
31, 2000;

        (b) by mutual consent of Purchaser and Sellers;

        (c) by Purchaser, if any representation or warranty of Sellers made in
or pursuant to this Agreement is untrue or incorrect in any material respect,
if Sellers materially breach the covenants or other terms of this Agreement,
or if any of the conditions precedent to Closing contained in Section 7 are
not satisfied; or

        (d) by Sellers, if any representation or warranty of Purchaser made in
or pursuant to this Agreement is untrue or incorrect in any material respect,
if Purchaser materially breaches the covenants or other terms of this
Agreement or if any of the conditions precedent to Closing contained in
Section 8 are not satisfied.

     12.2 Procedure for Termination. A party terminating this Agreement
pursuant to Section 11.1 shall give written notice thereof to the other party
hereto, whereupon this Agreement shall terminate and the transactions
contemplated hereby shall be abandoned without further action by any party.

     12.3 Effect of Termination. In the event of the termination of this
Agreement pursuant to the provisions of this Section 11, this Agreement shall
become void and have no effect, without any liability on the part of any of
the parties or their directors or officers or stockholders in respect of this
Agreement, except that the termination shall not relieve a breaching party
from liability incurred for the willful breach of this Agreement.



                                 ARTICLE 13

                                MISCELLANEOUS

     13.1 Knowledge. All references in this Agreement to the knowledge of CNS
or Connell Neurosurgical respecting a particular matter shall conclusively be
deemed and presumed to include, without limitation, all facts, circumstances
and conditions known to George J. Connell, CNS and Connell Neurosurgical, and
their respective directors, officers and employees regarding such matter.

     13.2 Survival of Representations and Warranties. The representations and
warranties made by the parties in this Agreement and in the Disclosure
Statement and the Schedules,


                                    -40-
<PAGE>

certificates, documents and Exhibits delivered pursuant hereto shall
survive the consummation of the transactions herein contemplated for a period
of eighteen (18) months, except that the representations and warranties set
forth in Sections 3.14, 3.16, and 3.18, shall remain in force for a period
corresponding to that of the applicable statute of limitations and the
representations and warranties set forth in Sections 3.1, 3.2, 3.7(a),
3.7(c), 4.1, 4.2 , 4.6(a) and 4.6(c) shall survive the consummation of the
transactions herein contemplated indefinitely. The survival period for
representations prescribed by this Section 13.2 is referred to as the
"Survival Period". Anything in this Agreement to the contrary notwithstanding,
the representations and warranties of Sellers hereunder, and the right of
Purchaser to indemnification for breach thereof, shall not be affected by any
investigation of Sellers, the Business or the Assets made by Purchaser or its
agents or representatives.

     13.3 Notification of Certain Events. Each party shall promptly notify
the other parties of any event or circumstance known to such party that could
prevent or delay the consummation of the transactions contemplated by this
Agreement, or which would indicate a breach of, non-compliance with, or
inaccuracy in any of the terms, conditions, representations, warranties or
agreements of any of the parties to this Agreement, or, in the case of
Sellers, any inaccuracy in or omission from the Disclosure Statement.
However, no such notification shall be deemed to cure any breach of or
inaccuracy in any representation or warranty, unless expressly so agreed by
the party to whom the representation or warranty is made.

     13.4 Costs and Expenses. Except as otherwise expressly provided herein,
each party shall bear its own expenses in connection herewith, including
without limitation any broker, legal, finders, investment banking and audit
fees and expenses, whether or not the Closing occurs. Any and all documentary
and similar taxes and fees and recording and filing fees incurred in
connection with the transactions contemplated herein shall be borne by CNS.

     13.5 Notices. All notices or other communications permitted or required
under this Agreement shall be in writing and shall be sufficiently given if
and when hand delivered to the persons set forth below, or if sent by
documented overnight delivery service or registered or certified mail,
postage prepaid, return receipt requested, or by telegram, telex or telecopy,
receipt acknowledged, addressed as set forth below or to such other person or
persons and/or at such other address or addresses as shall be furnished in
writing by any party hereto to the others. Any such notice or communication
shall be deemed to have been given as of the date received, in the case of
personal delivery, or on the date shown on the receipt or confirmation
therefor in all other cases.

                  To Purchaser:

                  Clinical Neuro Systems Holdings LLC
                  311-C Enterprise Drive
                  Plainsboro, NJ 08536
                  Attention: John B. Henneman, III
                  Telecopier: (609) 275-1082

                                    -41-
<PAGE>

                  With a copy to:


                  John E. Stoddard III, Esq.
                  Drinker Biddle & Shanley LLP
                  Suite 300
                  105 College Road East
                  Princeton, NJ 08542

                  Telecopier: (609) 799-7000


                  To Seller:

                  George J. Connell
                  President
                  Connell Neurosurgical
                  309 Commerce Drive
                  Exton, PA 19341-2616
                  Telecopier: (610) 524-3158 (call first)

                  With a copy to:

                  Kathleen M. Shay, Esq.
                  Duane, Morris & Heckscher LLP
                  One Liberty Place
                  Philadelphia, PA 19103-7396
                  Telecopier: (215) 979-1020

     13.6 Assignment and Benefit.

        (a) Neither Sellers nor George J. Connell shall assign this Agreement or
any rights hereunder, or delegate any obligations hereunder, without the
prior written consent of Purchaser. Subject to the foregoing, this Agreement
and the rights and obligations set forth herein shall inure to the benefit
of, and be binding upon, the parties hereto, and each of their respective
successors, heirs and assigns.

        (b) This Agreement shall not be construed as giving any person, other
than the parties hereto and their permitted successors, heirs and assigns,
any legal or equitable right, remedy or claim under or in respect of this
Agreement or any of the provisions herein contained, this Agreement and all
provisions and conditions hereof being intended to be, and being, for the
sole and exclusive benefit of such parties, and permitted successors, heirs
and assigns and for the benefit of no other person or entity

     13.7 Amendment, Modification and Waiver. The parties may, by mutual
agreement, amend or modify this Agreement in any respect. Any such amendment,
modification, extension or waiver shall be in writing. The waiver by a party
of any breach of any provision of this


                                    -42-
<PAGE>

Agreement shall not constitute or operate as a waiver of any other breach of
such provision or of any other provision hereof, nor shall any failure to
enforce any provision hereof operate as a waiver of such provision or of any
other provision hereof.

     13.8 Governing Law; Consent to Jurisdiction. This Agreement is made
pursuant to, and shall be construed and enforced in accordance with, the laws
of the Commonwealth of Pennsylvania (and United States federal law, to the
extent applicable), irrespective of the principal place of business,
residence or domicile of the parties hereto, and without giving effect to
otherwise applicable principles of conflicts of law. Each party agrees that
any suit arising out of or relating to this Agreement or any of the
transactions contemplated hereunder will be commenced in Pennsylvania state
court located in Philadelphia County or in the United States District Court
for the Eastern District of Pennsylvania, and each party waives any objection
which such party may now or hereafter have to the laying of the venue of any
such action, suit or proceeding, and irrevocably submits to the jurisdiction
of any such court. Any and all service of process and any other notice in any
such action, suit or proceeding shall be effective against any party if given
as provided in Section 12.6 herein. Nothing contained in this Section 12.9,
or elsewhere herein, shall be deemed to affect the right of any party to
serve process in any other manner permitted by law or to commence legal
proceedings or otherwise proceed against any other party in any jurisdiction
other than Pennsylvania. Nothing contained herein or in any Transaction
Document shall prevent or delay Purchaser, Sellers or George J. Connell from
seeking, in any court of competent jurisdiction, specific performance or
other equitable remedies in the event of any breach or intended breach by
Sellers, Purchaser or George J. Connell of any of its obligations hereunder.

     13.9 Public Announcements. No party hereto shall make any public
announcements or otherwise communicate with any news media with respect to
this Agreement or any of the transactions contemplated hereby without prior
consultation with the other parties as to the timing and content of any such
announcement; provided, however, that nothing contained herein shall prohibit
Purchaser from promptly making all filings with the Securities and Exchange
Commission, the National Association of Securities Dealers or any other state
or federal governmental authorities as may, in its judgment, be required in
connection with the execution and delivery of this Agreement or the
consummation of the transactions contemplated hereby.

     13.10 Further Actions and Assurances. Each of the parties hereto shall
use such party's best efforts to take such actions as may be necessary or
reasonably requested by the other parties hereto to carry out and consummate
the transactions contemplated by this Agreement. From time to time, at
Purchaser's request, whether at or after the Closing and without further
consideration, the Sellers shall execute and deliver such further instruments
of assignment, conveyance and transfer and take such other actions as
Purchaser may reasonably request to convey and transfer more effectively to
Purchaser any of the Assets. Purchaser shall, after the Closing, from time to
time, promptly execute, acknowledge and deliver any other assurances or
documents reasonably requested by the Sellers and Sellers shall provide
Purchaser with reasonable access to the Excluded Assets listed on Schedule
1.4(d) for a period of ninety (90) days following the Closing.

                                    -43-
<PAGE>

     13.11 Section Headings and Defined Terms. The section headings contained
herein are for reference purposes only and shall not in any way affect the
meaning and interpretation of this Agreement. The terms defined herein and in
any agreement executed in connection herewith include the plural as well as
the singular and the singular as well as the plural. Except as otherwise
indicated, all agreements defined herein refer to the same as from time to
time amended or supplemented or the terms thereof waived or modified in
accordance herewith and therewith.

     13.12 Severability. The invalidity or unenforceability of any particular
provision, or part of any provision, of this Agreement shall not affect the
other provisions or parts hereof, and this Agreement shall be construed in
all respects as if such invalid or unenforceable provisions or parts were
omitted.

     13.13 Counterparts. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original; and any person may
become a party hereto by executing a counterpart hereof, but all of such
counterparts together shall be deemed to be one and the same instrument. It
shall not be necessary in making proof of this Agreement or any counterpart
hereof to produce or account for any of the other counterparts.

     13.14 Entire Agreement, etc.

        (a) This Agreement, together with the Disclosure Statement and the
agreements, Exhibits, Schedules, appendices and certificates referred to
herein or delivered pursuant hereto, constitute the entire agreement between
the parties hereto with respect to the purchase and sale of the Business and
the Assets and supersede all prior agreements and understandings. The
Disclosure Statement and all Schedules, Exhibits and appendices attached
hereto and referred to herein are hereby incorporated herein and made a part
hereof as if fully set forth herein.

        (b) The disclosures in the Disclosure Statement shall relate only to the
representations and warranties to which they expressly refer and to no other
representation or warranty in this Agreement. In the event of any
inconsistency between the statements made in the body of this Agreement and
those contained in the Disclosure Statement (other than an express exception
to a specifically identified statement), those in this Agreement shall
control.

        (c) The submission of a draft of this Agreement or portions or summaries
thereof does not constitute an offer to purchase or sell the Business or the
Assets, it being understood and agreed that neither Purchaser nor Sellers
shall be legally obligated with respect to such a purchase or sale or to any
other terms or conditions set forth in such draft or portion or summary
unless and until this Agreement has been duly executed and delivered by all
parties.

                            [signature page follows]


                                    -44-
<PAGE>

     IN WITNESS WHEREOF, each of the parties hereto has duly executed this
Agreement, all as of the date first above written.

                         CLINICAL NEURO SYSTEMS HOLDINGS LLC

                         By:  Integra LifeSciences Corporation, its sole member


                         By:
                             ---------------------------------------------------
                                 Stuart M. Essig
                                 Chief Executive Officer


                         CLINICAL NEURO SYSTEMS, INC.

                         By:
                             ---------------------------------------------------
                                 George J. Connell
                                 President


                         SURGICAL SALES CORPORATION t/a CONNELL NEUROSURGICAL

                         By:
                             ---------------------------------------------------
                                 George J. Connell
                                 President



                         -------------------------------------------------------
                         GEORGE J. CONNELL


                                      -45-


<PAGE>


                                                                    Exhibit 10.1
                                  EXHIBIT A

            THIS NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES
               ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE
                SECURITIES LAW, AND MAY NOT BE SOLD, ASSIGNED,
                PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF
                 EXCEPT IN COMPLIANCE WITH APPLICABLE FEDERAL
                   AND STATE SECURITIES LAWS AND THE OTHER
                  RESTRICTIONS ON TRANSFER SET FORTH HEREIN.

        THIS NOTE IS SUBJECT TO MAKER'S RIGHT OF SET-OFF AS SET FORTH IN
                                SECTION 9 HEREOF.

                           SECURED PROMISSORY NOTE

$2,800,000                                                Plainsboro, New Jersey
                                                             January 14, 2000

     FOR VALUE RECEIVED, CLINICAL NEURO SYSTEMS HOLDINGS LLC, a Delaware
limited liability company ("Maker"), having an address at 311 Enterprise
Drive, Plainsboro, New Jersey 08536, promises to pay to the order of Clinical
Neuro Systems, Inc. ("Payee"), at 425 Lionville Road, Downingtown,
Pennsylvania 19335, or at such other address as may hereafter be specified by
Payee, in lawful money of the United States of America, the principal sum of
TWO MILLION EIGHT HUNDRED THOUSAND DOLLARS ($2,800,000) (subject to Maker's
right of set-off as provided in Section 9), together with interest at the
rate or rates and in the installments and at the times hereinafter provided.
The indebtedness evidenced by this Secured Promissory Note (this "Note")
represents a portion of the purchase price payable in accordance with, and
subject to, the terms and conditions of that certain Asset Purchase Agreement
among Maker, Payee and certain other persons listed therein dated as of the
date hereof (the "Purchase Agreement"). This Note is secured by a Security
Agreement dated the date hereof between Maker and Payee (the "Security
Agreement") and a Collateral Assignment between Maker and Payee of that
certain subordinated promissory note dated the date hereof from Integra
LifeSciences Corporation to Maker (the "Collateral Assignment").

     1. Interest Rate. All sums outstanding from time to time hereunder shall
bear interest until the date paid at the rate of five percent (5%) per annum,
such interest to be paid as provided in Section 2 below.

     2. Principal and Interest Payments.

        (a) The principal of and all accrued interest on this Note shall be paid
in two installments due and payable on January 15, 2001 and January 14, 2002.
Each installment will be equal to the sum of (i) One Million Four Hundred
Thousand Dollars ($1,400,000) of principal plus (ii) all accrued and unpaid
interest on the outstanding principal balance of this Note at the rate set
forth in Section 1 above.


<PAGE>

        (b) Both before and after any default, interest shall be calculated on
the basis of a 365-day year and the actual days elapsed.

        (c) In the event of set-off by Maker against this Note pursuant to
Section 9, Maker may set-off up to $1,400,000 against the prospective
principal amounts remaining payable under this Note in such order as Maker
shall determine and appropriate adjustments shall be made to the principal
and interest payments due under this Note.

     3. Prepayments. Maker may at any time prepay the principal of this Note
in whole or in part without penalty or premium; provided, however, that any
such prepayment shall be accompanied by the payment of all accrued and unpaid
interest hereunder and all other sums which may be payable hereunder or
otherwise in connection with this Note to the date of prepayment.

     4. Penalties. If any installment of principal or interest or both
hereunder is not paid within ten (10) days after becoming due, Maker shall
pay to Payee on demand interest at the annual rate of fifteen percent (15%)
of such overdue amount for the number of days such payment is overdue. The
amount of any such penalties not paid promptly following demand shall be
deemed outstanding and payable pursuant to this Note.

     5. Events of Default. Each of the following shall constitute an event of
default (each, an "Event of Default") hereunder:

        (a) If Maker fails to make any payment of any sums due hereunder when
due and such failure continues for ten (10) days after written notice thereof
is given by Payee to Maker; or

        (b) If Maker fails to observe or perform in any material respect its
obligations under the Security Agreement or the Collateral Assignment and
such failure continues for ten (10) days after written notice thereof is
given by Payee to Maker; or

        (c) If any proceeding under the Bankruptcy Code or any law of the United
States of America or of any state relating to insolvency, receivership, or
debt adjustment is instituted by Maker, or if any such proceeding is
instituted against Maker and is consented to by the respondent or an order
for relief shall be entered in such proceeding or such proceeding shall
remain undismissed for sixty (60) days, or if Maker becomes a debtor under
the Bankruptcy Code of the United States of America, or a trustee or receiver
is appointed for any substantial part of its property, or if Maker makes an
assignment for the benefit of creditors.

     6. Remedies. If an Event of Default occurs hereunder, at the option of
Payee, the entire principal balance, late fees, penalties and all accrued but
unpaid interest hereunder shall become immediately due and payable, and Payee
may thereupon exercise any rights or remedies provided for in this Note, the
Security Agreement, the Collateral Assignment or otherwise available at law
or in equity.

     7. Consent by Maker. Maker and the endorsers hereof and sureties therefor,
if any, and all others who may be liable for all or any part of the
indebtedness evidenced by this Note,


                                     -2-
<PAGE>

consent to any number of renewals or extensions of the time of payment
hereof without notice to any of those parties. The granting, without notice,
of any extension of time for the payment of any sum due under this Note or
for the performance at any covenant, condition or agreement hereof, shall in
no way release or discharge the liability of Maker or of any such endorsers
or sureties.

     8. Notices. All notices required to be given to any of the parties
hereunder shall be in writing and shall be deemed to have been sufficiently
given for all purposes when presented personally to such party or sent by
certified or registered mail, return receipt requested, or by courier service
with guaranteed next business day delivery, addressed to such party at its
address as set forth in the Purchase Agreement (and, in the case of Maker,
Payee shall also furnish a copy of any such notice delivered to Maker
hereunder to Drinker Biddle & Shanley LLP, 105 College Road East, Suite 300,
P.O. Box 627, Princeton, NJ 08542, Attention: John E. Stoddard III). Such
notice shall be deemed to be given when received if delivered personally, or
three (3) business days after the date deposited with the U. S. Postal
Service if sent by certified or registered mail, return receipt requested, or
one (1) business day after the same is delivered to a courier service with
guaranteed next business day delivery. Any notice of any change in such
address shall also be given in the manner set forth above.

     9. Maker's Right of Set-Off.

        (a) Notwithstanding anything to the contrary herein contained, Maker
shall be entitled to set off up to $1,400,000 of the principal amount hereof
against payments due under this Note amounts which Maker claims in good faith
represent damages sustained by it as a result of any breach by either Seller
(as defined in the Purchase Agreement) of such Seller's representations,
warranties or covenants contained in the Purchase Agreement and any other
amounts which Maker is entitled to set-off against such installments pursuant
to the Purchase Agreement. The procedure with respect to Maker's exercise of
its right of set off shall be as follows:

        (b) Not less than five (5) business days prior to the due date of any
payment under this Note, Maker shall send a notice to Payee specifying the
aggregate amount (the "Claimed Amount"), if any, that Maker has determined in
good faith that it is entitled to set off against sums due hereunder. Such
notice shall further set forth, with reasonable specificity, the right of set
off claimed and, if resulting from a breach by either Seller, (i) the
particular representations, warranties or covenants contained in the Purchase
Agreement breached by such Seller, (ii) the particular acts, occurrences,
circumstances or states of facts giving rise to each such breach, and (iii)
the amount of Maker's damages associated with each individual breach of the
representations, warranties or covenants contained in the Purchase Agreement
and the method of calculating each such item of damage.

        (c) Within 30 calendar days following the giving of the notice referred
to in the preceding paragraph, Payee shall send Maker a notice with respect
to Payee's acceptance or rejection of all or a portion of Maker's claims for
set off. If Payee disputes any of Maker's claims for set off or the amount of
any such claims, Payee's notice shall set forth with reasonable specificity
(i) the nature of Payee's objections and (ii) the amounts, if any, that Payee
believes Maker is entitled to set off against amounts payable hereunder (the
"Undisputed Set Off


                                     -3-
<PAGE>

Amount"). If Payee fails to give Maker such notice of dispute within
such time period set forth in this subsection, Payee shall be deemed to have
accepted Maker's set off of the Claimed Amount.

        (d) On such date as any payment required under this Note is due, Maker
shall make such payment, less the Claimed Amount, in accordance with the
terms and provisions of Section 2 hereof. Maker shall further deposit into an
interest bearing escrow account with an escrow agent mutually acceptable to
the parties hereto (the "Escrow Agent") the difference, if any, between the
Claimed Amount and the Undisputed Set Off Amount (the "Disputed Amount").
Payments made by Maker in accordance with this subsection shall constitute
compliance with Maker's payment obligations under this Note. Without limiting
the foregoing, interest shall cease to accrue under this Note on any Disputed
Amount upon delivery by Maker to Escrow Agent of the Disputed Amount. The
outstanding principal amount of this Note shall be reduced by any payments by
Maker to Payee or Escrow Agent pursuant to this Section 9(d).

        (e) For a period of thirty (30) days following the date of deposit of
the Disputed Amount with the Escrow Agent, Maker and Payee shall negotiate in
good faith with respect to the resolution of the controversy or dispute
between the parties with respect to such Disputed Amount. If such controversy
or dispute cannot be settled through negotiations between the parties, then
the parties shall attempt in good faith to settle such dispute by mediation
administered by the American Arbitration Association (the "AAA") in
Philadelphia, Pennsylvania under the Commercial Mediation Rules prior to
resorting to any other remedies available at law or in equity or in any other
dispute resolution procedure. If the parties fail to resolve any such dispute
through mediation, then the parties hereto shall settle the dispute by
arbitration administered by the AAA in Philadelphia, Pennsylvania under the
AAA's Commercial Arbitration Rules, and any judgment on the award rendered by
the arbitrator(s) may be entered in any court having jurisdiction thereof.
The remedies and procedures set forth in this section shall be the sole and
exclusive remedies available to each party hereto with respect to any
Disputed Amount.

        (f) The Escrow Agent shall continue to hold the Disputed Amount until
such time as the Escrow Agent receives (i) written notice signed by both
Maker and Payee with respect to the disposition of the Disputed Amount or
(ii) the written order of the applicable arbitration panel regarding the
disposition of the Disputed Amount. Promptly following receipt, Escrow Agent
shall distribute the Disputed Amount (together with any accrued interest
thereon) in accordance with such notice or order.

     10. Captions. The captions or headings of the Sections in this Note are
for convenience only and shall not control or affect the meaning or
construction of any of the terms or provisions of this Note.

     11. Governing Law; Amendment. This Note shall be governed by and
construed in accordance with the laws of the Commonwealth of Pennsylvania.
This Note may only be amended by an instrument in writing signed by both
Maker and Payee.

     12. Assignment. This Note is not assignable without the prior written
consent of the Maker, which consent may be withheld in Maker's sole and
absolute discretion, except for an


                                     -4-
<PAGE>

assignment of this Note to George J. Connell. Any assignment prohibited
by the preceding sentence shall be permitted only upon Maker receiving the
written consent of the assignee to Maker's right of set-off set forth in
Section 9 above. This Note, and Maker's right of set-off set forth in Section
9 above, shall be binding upon the respective legal representatives,
successors and permitted assigns of the parties hereto.


     IN WITNESS WHEREOF, each party hereto, intending to be legally bound
hereby, has caused this Note to be executed by its duly authorized officers,
the date and year first above written.

                                      CLINICAL NEURO SYSTEMS HOLDINGS LLC

                                      By:  Integra LifeSciences Corporation,
                                           its sole member


                                           By:
                                               --------------------------------
                                                  Stuart M. Essig
                                                  Chief Executive Officer


ACCEPTED AND AGREED:

CLINICAL NEURO SYSTEMS, INC.


By:
    -------------------------------
       George J. Connell
       President




- -----------------------------------
George J. Connell, as Assignee


                                     -5-



<PAGE>


                                                                   Exhibit 10.2
                              SECURITY AGREEMENT

     This SECURITY AGREEMENT is made and entered into as of this 14th day of
January 2000, by and among CLINICAL NEURO SYSTEMS HOLDINGS LLC, a Delaware
limited liability company (the "Borrower"), and CLINICAL NEURO SYSTEMS, INC.,
a Delaware corporation ("CNS"), and George Connell ("Connell") (and together
with CNS, the "Secured Party").

                                 Background:

     1. The Borrower and the Secured Party are parties to an Asset Purchase
Agreement dated as of January 14, 2000 (the "Asset Purchase Agreement"),
pursuant to which the Borrower is purchasing substantially all of the assets
of CNS for $4,004,000 in cash plus a promissory note (the "Note") in the
principal amount of $2,800,000.

     2. CNS is willing to accept the Note in payment for a portion of the
purchase price under the Asset Purchase Agreement only on the condition that
the Borrower executes and delivers this Security Agreement to the Secured
Party.

     3. Capitalized terms which are used herein without definition shall have
the meanings ascribed to them in the Asset Purchase Agreement. Other terms
used herein without definition that are defined in the Uniform Commercial
Code, as enacted in Pennsylvania and in effect on the date hereof (the
"Uniform Commercial Code"), shall have the meanings ascribed to them therein,
unless the context requires otherwise.

     NOW, THEREFORE, intending to be legally bound, the Borrower and the
Secured Party hereby agree as follows:

     Section 1. Creation of Security Interest. The Borrower hereby grants to
the Secured Party a lien and security interest in and to the property
hereinafter described, whether now owned or hereafter acquired or arising
(excluding hereafter acquired customer lists as set forth in subsection (g)
below) and wherever located ("Collateral"):

        (a) all inventory, whether raw materials, work-in-process, finished
goods, parts or supplies or otherwise; all goods, merchandise and other
property held for sale or lease or to be furnished under any contract of
service; all documents of title covering any goods that are or are to become
inventory and any such goods which are leased or consigned to others and all
returned, reclaimed or repossessed goods sold, consigned, leased or otherwise
furnished by the Borrower to others ("Inventory");


<PAGE>


        (b) all leases and rental agreements for personal property between the
Borrower as lessor (whether by origination or derivation) and any and all
persons or parties as lessee(s), and all rentals, purchase option amounts,
and other sums due thereunder; and all inventory, equipment, goods and
property subject to such leases and rental agreements and all accessions,
parts and tools attached thereto or used therewith and all of the Borrower's
residual or reversionary rights therein;

        (c) all machinery, equipment, furniture, fixtures, tools and all
accessories, parts and equipment now or hereafter attached thereto or used in
connection therewith, whether or not the same shall be deemed affixed to real
property, and all other tangible personal property ("Equipment");

        (d) all general intangibles, which term shall have the meaning given to
it in the Uniform Commercial Code and shall additionally include but not be
limited to all patents, trademarks, service marks, trade names, copyrights
and other intellectual property and proprietary rights;

        (e) all replacements, attachments, accretions, accessions, components
and substitutions to or for any Inventory or Equipment;

        (f) all books and records evidencing or relating to the foregoing,
including, without limitation, the customer list of the Borrower as
constituted on the date hereof, data storage and processing media, software
and related material, including computer programs, computer tapes, cards,
disks and printouts, and including any of the foregoing that are in the
possession of any affiliate or any computer service bureau; and

        (g) all proceeds, which term shall have the meaning given to it in the
Uniform Commercial Code and shall additionally include, but not be limited
to, whatever is received upon the use, lease, sale, exchange, collection or
other utilization or any disposition of any of the collateral described in
subparagraphs (a) through (e) above, whether cash or noncash, and including
without limitation, rental or lease payments, accounts, chattel paper,
instruments, documents, contract rights, general intangibles, equipment and
insurance proceeds, and all such proceeds of the foregoing, but excluding
proceeds of Inventory ("Proceeds").

     Section 2. Secured Obligations. The security interest created herein is
given as security for the prompt payment, performance, satisfaction and
discharge of the following obligations ("Obligations") of the Borrower:

        (a) to pay all obligations and liabilities of the Borrower to the
Secured Party under the Note and this Security Agreement in accordance with
the terms thereof; and


                                       -2-

<PAGE>


        (b) to reimburse the Secured Party, on demand, for all of the Secured
Party's expenses and costs, including the reasonable fees and expenses of its
counsel, in connection with the enforcement of the Note and this Security
Agreement.


     Section 3. Representations and Warranties. The Borrower represents and
warrants as follows:

        (a) Good Title to Collateral. The Secured Party has transferred to the
Borrower pursuant to the Asset Purchase Agreement good and marketable title
to the Collateral, free and clear of all liens and encumbrances other than
the security interests granted to the Secured Party hereunder.

        (b) Location of Books and Records. The locations of the offices where
the Borrower maintains its books and records concerning the Collateral are as
set forth in Exhibit A or at the location(s) hereafter disclosed to the Secured
Party pursuant to Section 5.03 hereof.

        (c) Chief Executive Office. The chief executive offices of the Borrower
are at the address set forth in Exhibit A or at the location(s) hereafter
disclosed to the Secured Party pursuant to Section 5.03 hereof.

        (d) Location of Inventory and Equipment. All Inventory and Equipment of
the Borrower is located at one or more of the addresses set forth in Exhibit A
or at the location(s) hereafter disclosed to the Secured Party pursuant to
Section 5.03 hereof.

     Section 4. Disposition and Use of Collateral.

        (a) Inventory. The Borrower shall be permitted to process and sell the
Inventory, but only to the extent that such processing and sale are conducted
in the ordinary course of the Borrower's business.

        (b) Equipment. The Borrower shall be permitted to use the Equipment in
the ordinary course of its business.


     Section 5. Covenants and Agreements of the Borrower.

                                     -3-
<PAGE>

        (a) Maintenance and Inspection of Books and Records. The Borrower shall
maintain complete and accurate books and records and shall make all necessary
entries therein to reflect the costs, values and locations of its Inventory
and Equipment and all payments, credits and adjustments thereto. The Borrower
shall keep the Secured Party fully informed as to the location of all such
books and records and shall permit the Secured Party and its authorized
agents, at any reasonable time upon at least two business days' notice to
inspect, audit and make copies of all books and records, data storage and
processing media, software, printouts, journals, orders, receipts, invoices,
correspondence and other documents and written or printed matter related to
any of the Collateral. The Secured Party's rights under this Section 5.01
shall be enforceable at law or in equity, and the Borrower consents to the
entry of judicial orders or injunctions enforcing specific performance of
such obligations under this Section 5.01.

        (b) Insurance of Collateral. The Borrower shall keep its Inventory and
Equipment insured against such perils, in such amounts and with such
insurance companies as Borrower deems appropriate to protect the respective
interests of the Borrower and the Secured Party. All insurance policies shall
name the Secured Party as lender loss payee and shall provide for not less
than 30 days' advance notice in writing to the Secured Party of any
cancellation thereof. The Secured Party shall have the right (but shall be
under no obligation) to pay any of the premiums on such insurance if Borrower
fails to do so. Any premiums paid by the Secured Party shall, if the Secured
Party so elects, be considered an advance at the highest rate of interest
provided in the Note, and all such advances shall be payable on demand. The
Borrower expressly authorizes its insurance carriers to pay proceeds of all
insurance policies covering any or all of the Collateral directly to the
Secured Party.

        (c) New Locations of Collateral and Books and Records. The Borrower
shall immediately notify the Secured Party of any change in the location of
its chief executive office, of any new or additional address where its books
and records concerning the Collateral are located and of any new locations of
Inventory or Equipment not specified in Sections 3.02, 3.03 or 3.04 of this
Security Agreement, and if any such location is on leased or mortgaged
premises, promptly furnish the Secured Party with landlord's or mortgagee's
waivers in form and substance reasonably satisfactory to the Secured Party.

        (d) Perfection of the Secured Party's Interests. The Borrower agrees to
cooperate and join with the Secured Party in taking such steps as are reasonably
necessary, in the Secured Party's judgment, to perfect or continue the perfected
status of the security interests granted hereunder, including, without
limitation, the execution and delivery of any financing statements, amendments
thereto and continuation statements, the obtaining of landlords' and mortgagees'
waivers reasonably required by the Secured Party, the notation of encumbrances
in favor of the Secured Party on certificates of title, and the execution and
filing of any collateral assignments and any other instruments reasonably
requested by the Secured Party to perfect its security interest in the
Collateral. The Secured Party is expressly authorized to file financing
statements without the Borrower's signature.

                                     -4-
<PAGE>

        (e) Maintenance of Inventory and Equipment. The Borrower shall care for
and preserve the Inventory and Equipment in good condition and repair,
ordinary wear and tear excepted, and will pay the cost of all replacement
parts, repairs to and maintenance of the Equipment. The Borrower will keep
complete and accurate maintenance records with respect to the Equipment.

        (f) Reimbursement and Indemnification. The Borrower agrees to reimburse
the Secured Party on demand for out-of-pocket expenses incurred in connection
with the Secured Party's exercise of its rights under this Security
Agreement. The Borrower agrees to indemnify the Secured Party and hold it
harmless against any costs, expenses, losses, damages and liabilities
(including reasonable attorney's fees) incurred in connection with this
Security Agreement, other than as a direct result of the Secured Party's
gross negligence or willful misconduct.

     Section 6. Power of Attorney. The Borrower hereby appoints the Secured
Party as its lawful attorney-in-fact to do, at the Secured Party's option,
and at the Borrower's expense and liability, all acts and things that the
Secured Party may deem necessary or desirable to effectuate its rights under
this Security Agreement, including without limitation, (a) file financing
statements and otherwise perfect any security interest granted hereby, (b)
correspond and negotiate directly with insurance carriers, (c) upon the
occurrence of a default hereunder, communicate with third parties for the
purpose of protecting or preserving the Collateral, and (d) upon the
occurrence of a default hereunder, in the Borrower's or the Secured Party's
name, to demand, collect, receive, and receipt for, compound, compromise,
settle and give acquittance for, and prosecute and discontinue or dismiss,
with or without prejudice, any suit or proceeding with any third party
respecting any of the Collateral.

     Section 7. Default. The occurrence of any one or more of the following
shall be a default hereunder:

        (a) Default Under Agreement. The occurrence of a default or Event of
Default under the Note.

        (b) Failure to Observe Covenants. The failure of the Borrower to keep,
observe or perform any provisions of this Security Agreement, which failure
is not cured and remedied within 15 days after notice thereof is given to the
Borrower.

        (c) Representations and Warranties. If any representation, warranty or
certificate furnished by the Borrower under or in connection with this
Security Agreement shall, at any time, be false or incorrect in any material
respect and shall not have been cured and remedied within 15 days after
notice thereof is given to the Borrower.

                                     -5-
<PAGE>

        (d) Secured Party's Rights upon Default. Upon the occurrence of a
default hereunder and at any time thereafter that a default is continuing,
the Secured Party may immediately and without notice do any or all of the
following, which rights and remedies are cumulative, may be exercised from
time to time that a default is continuing, and are in addition to any rights
and remedies available to the Secured Party under the Asset Purchase
Agreement or the Note:

        (e) Uniform Commercial Code Rights. Exercise any and all of the rights
and remedies of a secured party under the Uniform Commercial Code, including
the right to require the Borrower to assemble the Collateral and make it
available to the Secured Party at a place reasonably convenient to the
parties.

        (f) Operation of Collateral. Operate, utilize, recondition and/or
refurbish (at the Secured Party's sole option and discretion and in any
manner) any of the Collateral that is Equipment, for the purpose of enhancing
or preserving the value thereof or the value of any other Collateral.

        (g) Sale of Collateral. Upon ten calendar days' prior written notice to
the Borrower, which the Borrower hereby acknowledges to be sufficient,
commercially reasonable and proper, sell, lease or otherwise dispose of any
or all of the Collateral at any time and from time to time at public or
private sale, with or without advertisement thereof, and apply the proceeds
of any such sale first to the Secured Party's expenses in preparing the
Collateral for sale (including reasonable attorneys' fees) and second to the
complete satisfaction of the Obligations. The Borrower waives the benefit of
any marshaling doctrine with respect to the Secured Party's exercise of its
rights hereunder. Upon the occurrence of a default hereunder, and at any time
thereafter that a default is continuing, the Borrower grants a royalty-free
license to the Secured Party for all patents, service marks, trademarks,
trade names, copyrights, computer programs and other intellectual property
and proprietary rights sufficient to permit Secured Party to exercise all
rights granted to Secured Party under this Section.

        (h) Notices. Any written notices required or permitted by this Security
Agreement shall be effective if delivered in accordance with paragraph 8 of
the Note.

     Section 8. Miscellaneous.

        (a) No Waiver. No delay or omission by the Secured Party in exercising
any right or remedy hereunder shall operate as a waiver thereof or of any
other right or remedy, and no single or partial exercise thereof shall
preclude any further exercise thereof or the exercise of any other right or
remedy.


                                     -6-
<PAGE>

        (b) Successors. The provisions of this Security Agreement shall inure to
the benefit of and be binding upon the Secured Party and the Borrower and
their respective successors and assigns, provided that the Borrower's
obligations hereunder may not be assigned without the written consent of the
Secured Party. The Borrower acknowledges that CNS intends to liquidate and
dissolve promptly after the date of this Agreement, whereupon CNS intends to
distribute the Note and its rights under the Asset Purchase Agreement and
this Agreement to George J. Connell, its sole stockholder. Upon such
distribution, George J. Connell shall be the Secured Party hereunder.

        (c) Amendments. No modification, rescission, waiver, release or
amendment of any provisions of this Security Agreement shall be effective
unless set forth in a written agreement signed by the Borrower and an
authorized officer of the Secured Party.

        (d) Governing Law. This Security Agreement shall be construed under the
internal laws of the Commonwealth of Pennsylvania without reference to
conflict of laws principles.

        (e) Severability. If any provision of this Security Agreement shall be
held invalid or unenforceable under applicable law in any jurisdiction, such
invalidity or unenforceability shall not affect the validity or
enforceability of such provision in any other jurisdiction or the validity or
enforceability of any other provision of this Security Agreement that can be
given effect without such invalid or unenforceable provision.


                                     -7-
<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this Security
Agreement to be executed and delivered by their authorized officers the day
and year first above written.

                                           CLINICAL NEURO SYSTEMS
                                           HOLDINGS LLC

                                           By: Integra LifeSciences Corporation,
                                               its sole member


                                           By:
                                               ---------------------------------
                                               Stuart M. Essig
                                               Chief Executive Officer


                                           CLINICAL NEURO SYSTEMS, INC.


                                           By:
                                               ---------------------------------
                                               George J. Connell
                                               President



                                           -------------------------------------
                                           GEORGE J. CONNELL




                                     -8-
<PAGE>

                                  EXHIBIT A
                                  ---------

Location of books and records:

309 Commerce Drive
Exton, PA 19341


Location of chief executive office:

309 Commerce Drive
Exton, PA 19341


Location of Inventory and Equipment:

309 Commerce Drive
Exton, PA 19341


                                       -9-



<PAGE>


                                                                    Exhibit 10.3
                            COLLATERAL ASSIGNMENT

     COLLATERAL ASSIGNMENT (this "Assignment") dated January 14, 2000 from
CLINICAL NEURO SYSTEMS HOLDINGS LLC, a Delaware limited liability company
(the "Assignor"), to CLINICAL NEURO SYSTEMS, INC., a Delaware corporation
("CNS"), and GEORGE J. CONNELL ("Connell"; together with CNS, the
"Assignee").

                                  BACKGROUND

     A. The Assignor and the Assignee are parties to an Asset Purchase
Agreement dated as of January 14, 2000 (the "Asset Purchase Agreement"),
pursuant to which the Assignor is purchasing substantially all of the assets
of CNS for $4,004,000 in cash plus a secured promissory note (the "CNS Note")
in the principal amount of $2,800,000.

     B. Assignor is the holder of a subordinated promissory note payable to
Assignor by its sole member, Integra LifeSciences Corporation ("Integra"), in
the principal sum of $2,800,000 (the "Integra Note"), which represents a
contribution of capital by Integra to Assignor, its wholly owned subsidiary.

     C. Assignor intends to secure its obligations under the CNS Note, in
part, by assigning the Integra Note to Assignee as collateral pursuant to
this Agreement.

     D. CNS is willing to accept the CNS Note in payment of a portion of the
purchase price under the Asset Purchase Agreement only on the condition that
the Assignor executes and delivers this collateral assignment of the Integra
Note to Assignee.

     E. CNS intends to liquidate and dissolve promptly after the date of this
Agreement, whereupon CNS intends to distribute the CNS Note and the Integra
Note and its rights under the Asset Purchase Agreement and this Agreement to
George J. Connell as its sole stockholder, and upon such distribution, George
J. Connell shall be the sole Assignee hereunder.

     NOW, THEREFORE, the parties hereto, intending to be legally bound,
hereby agree as follows:

     1. Assignment.

        (a) As security for the repayment of the CNS Note and the performance
and satisfaction of all other obligations of the Assignor under the CNS Note,
Assignor hereby collaterally assigns, transfers and sets over to the Assignee
and grants to the Assignee a security interest in and to all of Assignor's
right, title, and interest in and to the Integra Note and all monies due and
to become due under the Integra Note, and all rights, remedies and benefits
arising thereunder, with full power and right in the Assignee's own name or
in Assignor's name


<PAGE>

to take all such legal or other action as may be necessary to enforce the
provisions of the Integra Note;

        (b) Upon the occurrence and during the continuance of an event of
default under the CNS Note, Assignor irrevocably appoints the Assignee its
attorney, with power of substitution, to sue for, receive, collect,
compromise and adjust, and give releases for the monies due or to become due,
and authorizes and empowers the Assignee to endorse Assignor's name on, and
collect, all checks or other proceeds received by the Assignor under the
Integra Note.

     2. Payments under the Note. Until the occurrence of an event of default
under the CNS Note, all payments under the Integra Note shall be made to
Assignor. Upon the occurrence and during the continuance of an event of
default under the CNS Note, at the Assignee's discretion, all payments under
the Integra Note (whether upon demand or otherwise) shall be made to the
Assignee and shall be applied by the Assignee against the sums due under the
CNS Note, and the Assignee shall be permitted to take all actions to collect
all payments under the Integra Note. In the event Integra shall make any
payments under the Integra Note to Assignor in contravention of this
Agreement, Assignor shall receive and hold such payments in trust for the
benefit of the Assignee and shall immediately pay over such payment to the
Assignee.

     3. Representations and Warranties of Assignor. Assignor represents and
warrants as follows:

        (a) Assignor has not previously assigned, transferred or pledged the
Integra Note and no other person or entity has any right, title or interest
thereto.


        (b) The Integra Note and Integra's remaining obligations thereunder are
in full force and effect and enforceable in accordance with their terms, except
as such enforcement may be limited by bankruptcy, insolvency or other laws of
general application relating to or effecting the enforcement of creditors'
rights and except as enforcement is subject to general equitable principles.

        (c) No default has occurred under the Integra Note. Integra has no
defenses, setoffs or counterclaims to payment under the Integra Note, except
as expressly set forth therein.

        (d) Assignor is the lawful holder of and owner of all rights under the
Integra Note, and has the right and ability to assign the Integra Note and
has the full right and title to the Integra Note free from any lien, security
interest, encumbrance or other right whatsoever.

        (e) Assignor shall perform and fulfill all obligations and conditions to
be performed and fulfilled under the Integra Note, if any, and expressly
acknowledges that no duties thereunder are being imposed upon or delegated to
the Assignee.

<PAGE>

     4. Delivery of Note. Assignor has delivered the Integra Note to the
Assignee concurrently herewith.

     5. Modifications. Assignor shall not consent to any changes or
modifications to the Integra Note, nor waive, excuse, condone or in any
manner release or discharge any covenant or agreement of Integra under the
Integra Note without the Assignee's prior written consent.

     6. Communications. Assignor, promptly upon its receipt thereof, shall
provide the Assignee with copies of all notices and other communications
received by Assignor from or on behalf of Integra and relating in any way to
the Integra Note.

     7. Notices. Any written notices required or permitted by this Agreement
shall be effective if delivered in accordance with paragraph 8 of the CNS
Note.

     8. Miscellaneous.

        (a) This Assignment shall be governed by and construed in accordance
with the laws of the Commonwealth of Pennsylvania.

        (b) This Assignment shall be binding upon Assignor, its successors and
assigns and shall inure to the benefit of the Assignee, its successors and
assigns.

        (c) This Assignment contains the entire agreement of the parties with
respect to the subject matter hereof and no representation, inducement,
promise or agreement between the parties with respect to the subject matter
hereof which is not embodied herein shall be of any force or effect.

        (d) This Assignment may not be modified, amended or otherwise altered,
except by written agreement executed by Assignor and Assignee.

        (e) CNS and Connell acknowledge and agree to the subordination
provisions of the Integra Note.


<PAGE>


     IN WITNESS WHEREOF, Assignor and the Assignee have executed this
Assignment as of the date written above.


                                 Assignor:

                                 CLINICAL NEURO SYSTEMS HOLDINGS LLC

                                 By:  Integra LifeSciences Corporation, its sole
                                      member


                                 By:
                                     -------------------------------------------
                                     Stuart M. Essig, Chief Executive Officer


                                 Assignee:

                                 CLINICAL NEURO SYSTEMS, INC.


                                 By:
                                     -------------------------------------------
                                     George J. Connell, President


                                 -----------------------------------------------
                                 GEORGE J. CONNELL

APPROVED AND AGREED:

INTEGRA LIFESCIENCES
CORPORATION


By:
    ----------------------------
     Stuart M. Essig,
     Chief Executive Officer



<PAGE>


                                                                    Exhibit 10.4

           THIS SUBORDINATED NOTE HAS NOT BEEN REGISTERED UNDER THE
         SECURITIES ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE
                SECURITIES LAW, AND MAY NOT BE SOLD, ASSIGNED,
                PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF
                 EXCEPT IN COMPLIANCE WITH APPLICABLE FEDERAL
                   AND STATE SECURITIES LAWS AND THE OTHER
                  RESTRICTIONS ON TRANSFER SET FORTH HEREIN.


                         SUBORDINATED PROMISSORY NOTE

$2,800,000                                               Plainsboro, New Jersey
                                                            January 14, 2000

     FOR VALUE RECEIVED, INTEGRA LIFESCIENCES CORPORATION, a Delaware
corporation ("Maker") having offices at 311-C Enterprise Drive, Plainsboro,
New Jersey 08536, promises to pay to the order of CLINICAL NEURO SYSTEMS
HOLDINGS LLC, a Delaware limited liability company ("Payee"), in lawful money
of the United States of America, at the offices of Payee at 311-C Enterprise
Drive, Plainsboro, New Jersey 08536, the principal sum of TWO MILLION EIGHT
HUNDRED THOUSAND DOLLARS ($2,800,000), together with interest at the rate or
rates and in the installments and at the times hereinafter provided.

     1. Interest Rate. All sums outstanding from time to time hereunder shall
bear interest until the date paid at the rate of five percent (5%) per annum,
such interest to be paid as provided in Section 2 below.

     2. Principal and Interest Payments.

        (a) The principal of and all accrued interest on this Subordinated Note
shall be paid in two installments due and payable on January 15, 2001 and
January 14, 2002. Each installment will be equal to the sum of (i) One
Million Four Hundred Thousand Dollars ($1,400,000) of principal plus (ii) all
accrued and unpaid interest on the outstanding principal balance of this
Subordinated Note at the rate set forth in Section 1 above. Each such
installment shall first be applied to the payment of interest on the
outstanding principal of this Subordinated Note, and the remainder thereof
shall be applied on account of such principal.

        (b) Both before and after any default, interest shall be calculated on
the basis of a 365-day year and the actual days elapsed.

     3. Prepayments. Maker may not at any time prepay the principal of this
Subordinated Note in whole or in part.

     4. Penalties. If any installment of principal or interest or both
hereunder is not paid within ten (10) days after becoming due, Maker shall
pay to Payee on demand interest at the annual rate of fifteen percent (15%)
of such overdue amount for the number of days such

<PAGE>

payment is overdue. The amount of any such penalties not paid promptly
following demand shall be deemed outstanding and payable pursuant to this
Subordinated Note.

     5. Events of Default. Each of the following shall constitute an event of
default (each, an "Event of Default") hereunder:

        (a) If any proceeding under the Bankruptcy Code or any law of the United
States of America or of any state relating to insolvency, receivership, or debt
adjustment is instituted by Maker, or if any such proceeding is instituted
against Maker and is consented to by the respondent or an order for relief shall
be entered in such proceeding or such proceeding shall remain undismissed for
sixty (60) days, or if Maker becomes a debtor under the Bankruptcy Code of the
United States of America, or a trustee or receiver is appointed for any
substantial part of its property, or if Maker makes an assignment for the
benefit of creditors; or

        (b) There occurs an event of default under that certain Secured
Promissory Note, dated the date hereof, issued by Payee to Clinical Neuro
Systems, Inc.

     6. Remedies. If an Event of Default occurs hereunder, at the option of
Payee, the entire principal balance, late fees, penalties and all accrued but
unpaid interest hereunder shall become immediately due and payable, and Payee
may thereupon exercise any rights or remedies provided for in this
Subordinated Note or otherwise available at law or in equity.

     7. Subordination. Notwithstanding any other provision of this
Subordinated Note to the contrary:

     7.1 The payment and performance of the principal, interest and expense
reimbursement obligations evidenced by this Subordinated Note (collectively,
the "Subordinated Debt") are subordinated to the Senior Obligations (as
hereinafter defined) and, except for Permitted Payments (as hereinafter
defined), the Payee will have no right to ask, demand, sue for, take or
receive from the Maker, by setoff or in any other manner of the whole or any
part of the Subordinated Debt which may now or hereafter be owing by the
Maker, no right to enforce any claim with respect to the Subordinated Debt,
or otherwise to take any action against the Maker or Maker's property, unless
and until all such Senior Obligations, whether now existing or hereafter
arising, and whether such Senior Obligations arise after the Maker or the
Maker's estate becomes the subject of proceedings under the Bankruptcy Code
or whether such Senior Obligations are acquired outright, conditionally or as
collateral security from another by any existing or future holder of Senior
Obligations, shall have been fully paid and satisfied with interest,
including interest on any loans or advances made to the Maker after the Maker
or the Maker's estate becomes the subject of proceedings under Title 11 of
the United States Code, 11 U.S.C. ss. 101 et seq. or any replacement or
supplemental federal statute dealing with the bankruptcy of debtors (the
"Bankruptcy Code") and all commitments under the documents evidencing any of
the Senior Obligations have expired or been terminated.


                                     -2-

<PAGE>

     7.2. As used in this Section 7:

          "Credit Accommodation" means (a) any bond issued or guaranteed by,
     or any loan or advance now or hereafter made to or guaranteed by, the
     Maker, including any financing or extension of credit provided to the
     Maker pursuant to Section 363 or 364 of the Bankruptcy Code, (b) any
     bankers acceptance or letter of credit now or hereafter issued by or for
     the account of the Maker or as to which the Maker has guaranteed
     repayment or reimbursement, (c) any overdraft now or hereafter permitted
     to occur in any deposit account of the Maker, (d) any forward foreign
     exchange contract, interest rate or currency swap or other derivative
     now or hereafter issued to or for the benefit of the Maker or as to
     which the Maker has guaranteed payment, and (e) any securitization
     facility or structured financing with respect to the Maker's receivables
     and/or other financial assets now or hereafter arising.

          "Permitted Payments" shall mean all regularly scheduled payments of
     principal and interest of the Subordinated Debt that are made prior to
     written notice to Payee of a matured event of default (specifying
     whether such default is a payment default or other default) under the
     documents and instruments now or hereafter governing any of the Senior
     Obligations (as such documents may be amended, restated, replaced and/or
     otherwise modified from time to time in the sole discretion of the Maker
     and any existing or future holder of any Senior Obligations, regardless
     of whether the Payee receives notice of any such amendment, restatement,
     replacement and/or other modification or of the incurrence of any Senior
     Obligations) or after the cure of such matured event of default,
     provided that regularly scheduled payments of principal and interest on
     the Subordinated Debt may resume nine months after written notice of any
     event of default which is not a payment default.

          "Senior Obligations" shall mean any and all obligations of the
     Maker (whether for principal, interest accruing before or after the
     commencement of a case under the Bankruptcy Code whether or not such
     interest is permitted to be paid by the Maker, premium, fees,
     indemnities, expense reimbursements, costs of collection and enforcement
     or preservation and protection of collateral or otherwise) which may now
     or at any time hereafter be owing by the Maker in respect of any Credit
     Accommodation as to which the material transaction document(s) signed by
     the Maker specifically state(s) that such Credit Accommodation is
     intended to constitute a Senior Obligation pursuant to the terms of this
     Section 7; provided, however, that in no event will the aggregate
     principal amount of Senior Obligations at any one time outstanding
     exceed $10,000,000, plus interest and fees in respect thereof and
     reasonable costs of collection and enforcement thereof.

     7.3. In the event of any distribution, division, or application, partial
or complete, voluntary or involuntary, by operation of law or otherwise, of
all or any part of the assets of the Maker or the proceeds thereof to the
creditors of the Maker or readjustment of the Senior Obligations and
Subordinated Debt, whether by reason of liquidation, bankruptcy, arrangement,

                                     -3-

<PAGE>

receivership, assignment for the benefit of creditors or any other action or
proceeding involving the readjustment of all or any part of the Senior
Obligations or the Subordinated Debt, or the application of the assets of the
Maker to the payment or liquidation thereof, or upon the dissolution or other
winding up of the Maker's business, or upon the sale of all or substantially
all of the Maker's assets, then, and in any such event, (i) the holder(s) of
the Senior Obligations shall be entitled to receive payment in full of any
and all of the Senior Obligations then owing prior to the payment of all or
any part of the Subordinated Debt, and (ii) any payment or distribution of
any kind or character, whether in cash, securities or other property, which
shall be payable or deliverable upon or with respect to any or all of the
Subordinated Debt shall be paid or delivered directly to the holder(s) of the
Senior Obligations for application on any of the Senior Obligations, due or
not due, until such Senior Obligations shall have first been fully paid and
satisfied.

     7.4. Except for Permitted Payments, should any payment or distribution
or security or instrument or proceeds thereof be received by the Payee upon
or with respect to the Subordinated Debt prior to the satisfaction of all of
the Senior Obligations, the Payee shall be required to receive and hold the
same in trust, as trustee, for the benefit of the holder(s) of the Senior
Obligations, and shall forthwith deliver the same to such holder(s), in
precisely the form received (except for the endorsement or assignment of the
Payee where necessary), for application on any of the Senior Obligations, due
or not due, and, until so delivered, the same shall be held in trust by the
Payee as the property of the holder(s) of the Senior Obligations.

     7.5. The provision of this Section 7 shall be effective and may not be
terminated or otherwise revoked until the Senior Obligations shall have been
fully discharged and all commitments to extend additional Senior Obligations
have been terminated. In the event the Payee shall have any right under
applicable law or otherwise to terminate or revoke the provisions of this
Section 7 which right cannot be waived, such termination or revocation shall
not be effective until written notice of such termination or revocation,
signed by the Payee, is actually received by the holder(s) of the Senior
Obligations. In the absence of the circumstances described in the immediately
preceding sentence, this is a continuing agreement of subordination and
existing and future holder(s) of Senior Obligations may commence and/or
continue, at any time and without notice to the Payee, to extend credit or
other financial accommodations and loan monies to or for the benefit of the
Maker on the faith hereof. Any termination or revocation described
hereinabove shall not affect the provisions of this Section 7 in relation to
(a) any of the Senior Obligations which arose prior to receipt thereof, (b)
any of the Senior Obligations which represent interest on Senior Obligations,
or (c) any of the Senior Obligations created after receipt thereof, if such
Obligations were incurred either through extensions of credit by the
holder(s) of Senior Obligations pursuant to financing arrangements with the
Maker in an aggregate principal amount at any one time outstanding amount not
to exceed $10,000,000, and/or for the purpose of preserving or protecting any
collateral (including, but not limited to, all protective advances, costs,
expenses) and/or for attorneys' and paralegals' fees, whensoever made,
advanced or incurred by any holder of Senior Obligations in connection with
the Senior Obligations.

     7.6. IN ACCEPTING THIS SUBORDINATED NOTE, THE PAYEE EXPRESSLY WAIVES ALL
NOTICE OF THE ACCEPTANCE BY ANY EXISTING OR FUTURE HOLDER OF SENIOR
OBLIGATIONS OF THE SUBORDINATION AND OTHER PROVISIONS OF THIS SECTION 7 AND
ALL OTHER NOTICES NOT

                                     -4-

<PAGE>

SPECIFICALLY REQUIRED PURSUANT TO THE TERMS OF THIS SECTION 7 WHATSOEVER, AND
THE PAYEE EXPRESSLY WAIVES RELIANCE BY ANY SUCH HOLDER OF SENIOR OBLIGATIONS
UPON THE SUBORDINATION AND OTHER AGREEMENTS AS HEREIN PROVIDED.

     7.7. If the Maker or the Maker's estate becomes the subject of
proceedings under the Bankruptcy Code and if any existing or future holder of
Senior Obligations desires to permit the use of cash collateral or to provide
financing to the Maker under either Section 363 or Section 364 of the
Bankruptcy Code, by accepting this Subordinated Note, the Payee agrees that
adequate notice of such financing to the Payee shall have been provided if
the Payee received notice two (2) business days prior to the entry of any
order approving such cash collateral usage or financing. All allocations of
payments between the holder(s) of the Senior Obligations and the Payee shall,
subject to any court order, continue to be made after the filing of a
petition under the Bankruptcy Code on the same basis that the payments were
to be allocated prior to the date of such filing. By accepting this
Subordinated Note, the Payee agrees: (a) in the event that the Payee has or
at any time acquires any security for the Subordinated Debt, not to assert
any right it may have to "adequate protection" of its interest in such
security in any bankruptcy proceeding and not to seek to have the automatic
stay lifted with respect to such security, without the prior written consent
of each holder of Senior Obligations, and (b) the Payee waives any claim or
defense the Payee may now or hereafter have arising out of the election by
any holder of Senior Obligations, in any proceeding instituted under Chapter
11 of the Bankruptcy Code, of the application of Section 1111(b)(2) of the
Bankruptcy Code, and/or any borrowing or grant of a security interest under
Section 364 of the Bankruptcy Code by the Maker, as debtor-in-possession. To
the extent that any holder of Senior Obligations receives payments on, or
proceeds of collateral for, the Senior Obligations which are subsequently
invalidated, declared to be fraudulent or preferential, set aside and/or
required to be repaid to a trustee, receiver or any other party under any
bankruptcy law, state or federal law, common law, or equitable cause, then,
to the extent of such payment or proceeds received, the Senior Obligations,
or part thereof, intended to be satisfied shall be revived and continue in
full force and effect as if such payments or proceeds had not been received
by such holder of Senior Obligations.

     7.8 Nothing in this Section 7 or elsewhere in this Subordinated Note is
intended to or shall impair, as between the Maker, its creditors other than
the holders of the Senior Obligations, and the holders of this Subordinated
Note, the obligation of the Maker, which is absolute and unconditional, to
pay to the holders of this Subordinated Note the principal interest on this
Subordinated Note as and when the same shall become due and payable in
accordance with its terms, or is intended to or shall affect the relative
rights of the holders of this Subordinated Note and the creditors of the
Maker other than the holders of the Senior Obligations.

     8. Consent by Maker. Maker and the endorsers hereof and sureties
therefor, if any, and all others who may be liable for all or any part of the
indebtedness evidenced by this Subordinated Note, consent to any number of
renewals or extensions of the time of payment hereof without notice to any of
those parties. The granting, without notice, of any extension of time for the
payment of any sum due under this Subordinated Note or for the performance at
any covenant, condition or agreement hereof, shall in no way release or
discharge the liability of Maker or of any such endorsers or sureties.

                                     -5-

<PAGE>

     9. Notices. All notices required to be given to any of the parties
hereunder shall be in writing and shall be deemed to have been sufficiently
given for all purposes when presented personally to such party or sent by
certified or registered mail, return receipt requested, or by courier service
with guaranteed next business day delivery, addressed to such party at its
address provided herein. Such notice shall be deemed to be given when
received if delivered personally, or three (3) business days after the date
deposited with the U. S. Postal Service if sent by certified or registered
mail, return receipt requested, or one (1) business day after the same is
delivered to a courier service with guaranteed next business day delivery.
Any notice of any change in such address shall also be given in the manner
set forth above.

     10. Captions. The captions or headings of the Sections in this
Subordinated Note are for convenience only and shall not control or affect
the meaning or construction of any of the terms or provisions of this
Subordinated Note.

     11. Governing Law; Amendment. This Subordinated Note shall be governed
by and construed in accordance with the laws of the Commonwealth of
Pennsylvania. This Subordinated Note may only be amended by an instrument in
writing signed by both Maker and Payee.

     12. Assignment. This Subordinated Note is not assignable without the
prior written consent of the Maker, which consent may be withheld in Maker's
sole and absolute discretion. This Subordinated Note shall be binding upon
the respective legal representatives, successors and permitted assigns of the
parties hereto.

     IN WITNESS WHEREOF, each party hereto, intending to be legally bound
hereby, has caused this Subordinated Note to be executed by its duly
authorized officers, the date and year first above written.

                                      INTEGRA LIFESCIENCES CORPORATION


                                      By:
                                          -------------------------------------
                                            Stuart M. Essig
                                            Chief Executive Officer



ACCEPTED AND AGREED:

CLINICAL NEURO SYSTEMS HOLDINGS LLC

By:  Integra LifeSciences Corporation, its sole member


By:
    -----------------------------------
       Stuart M. Essig
       Chief Executive Officer



                                     -6-


<PAGE>


                                                                    Exhibit 10.5

                             CONSULTING AGREEMENT

     This Agreement (the "Agreement"), entered into as of January 14, 2000
(the "Effective Date"), is between Integra LifeSciences Corporation, a
Delaware corporation having a place of business at 311-C Enterprise Drive,
Plainsboro, New Jersey 08536 ("Integra"), and George J. Connell (hereinafter
referred to as "Consultant").

     WHEREAS, Clinical Neuro Systems Holdings LLC, a wholly-owned subsidiary
of Integra ("Purchaser"), has acquired substantially all of the assets of
Clinical Neuro Systems, Inc. ("CNS"), a manufacturer of neurosurgical
products, and certain assets relating to the distribution of CNS' products
owned by Surgical Sales Corporation (trading as Connell Neurosurgical)
("Connell"), pursuant to an Asset Purchase Agreement dated as of the date
hereof (the "Purchase Agreement");

     WHEREAS, all of the outstanding capital stock of both CNS and Connell is
held by Consultant;

     WHEREAS, Consultant has expertise in the field of marketing, sales and
manufacture of neurosurgical products;

     WHEREAS, Integra desires to hire Consultant as a consultant to Integra
to assist in the transition of the CNS business and otherwise to advise
Integra in the marketing, sales, distribution and manufacture of
neurosurgical devices;

     WHEREAS, in consultant's role as Consultant to Integra, Consultant will
work closely with Integra materials, proprietary information, Confidential
Information and market strategies and it is therefore considered reasonable
and necessary that Consultant comply with the provisions of this Agreement
and the Purchase Agreement related to confidentiality and non-competition.

     NOW THEREFORE, the parties mutually agree as follows:

1.   DEFINITIONS.

     1.1  Affiliate. The term "Affiliate" means with respect to a party to
          this Agreement, any corporation, company, limited liability
          company, partnership, joint venture and/or firm (i) which controls,
          is controlled by or is under common control with such party, or
          (ii) in which such party or any parent or subsidiary owns, or has a
          contractual right to acquire, an equity interest, or (iii) which
          has been licensed by such party or its parent or subsidiary, or
          which has retained such party or its parent or subsidiary, to
          perform research with respect to, or to commercially exploit, such
          party's or its parent's or subsidiary's technological assets.

<PAGE>

     1.2  Confidential Information. The term "Confidential Information" means
          information, documents or other materials which may be unpublished,
          including without limitation, information or documents furnished to
          Consultant for purposes of Consultant's performance hereunder or
          which are otherwise furnished to or come to the attention of
          Consultant, unpatented technical and other information which is not
          in the public domain, information in written form marked
          "Confidential", information disclosed orally by Integra to
          Consultant whether or not identified as "Confidential", information
          that consists of, or relates to, any unpublished patent application
          and material embodiments thereof, technical specifications,
          concepts, discoveries, data, formula, inventions, procedures for
          experiments and tests and results of experimentation and testing,
          results of research, specifications and techniques, economic
          information, business or research strategies, trade secrets,
          existing and potential customers, suppliers, markets, contracts,
          prices, products, personnel, strategies, policies, systems,
          procedures, technologies, know-how, information, processes,
          inventions, formulations, applications, operating manuals, services
          information concerning current, future or proposed products and
          services, product and service descriptions, financial or customer
          or client or prospective client or client lists and printouts,
          records, and any or all other information, data or material
          relating to the business, trade secrets and technology of Integra
          and/or any of its Affiliates. "Confidential Information" shall not
          include any information to the extent that any such information as
          of the date of disclosure to Consultant was (i) known to Consultant
          and such knowledge can be substantiated by reasonable
          documentation; (ii) disclosed in published literature; (iii)
          generally available to the industry; or (iv) obtained by Consultant
          from a third party, provided that such third party had no
          obligation of confidentiality to Integra or any of its Affiliates
          relating to the Confidential Information.

     1.3  Contract Period. The term "Contract Period" means the period
          beginning with the Effective Date of this Agreement and ending on
          the date on which this Agreement terminates in accordance with the
          provisions of Section 6 (Term and Termination; Survival) hereof.

     1.4  Field. The term "Field" means the manufacture or sale of any
          medical device sold or used in hospital intensive care units,
          including without limitation, cranial access kits, cranial access
          pressure devices, drainage bags and catheters.

     1.5  Integra Group. The term "Integra Group" means Integra and its
          Affiliates.


                                       2

<PAGE>


2.   SERVICES TO BE PERFORMED BY CONSULTANT.

     2.1  Consulting Services. Subject to the terms and conditions of this
          Agreement, throughout the Contract Period Consultant agrees to
          render such consulting services relating to the manufacture,
          marketing or sale of products in the Field, as may be requested
          from time to time by or at the direction of the Chief Executive
          Officer of Integra.

     2.2  Amount of Time for Consulting Projects. Consultant agrees to be
          available to the Integra Group to render consulting services for an
          aggregate of not more than 1000 hours during the Contract Period
          and, subject to such limitation, not more than 125 hours in any
          calendar month. Consultant's consulting services will be carried
          out at the facilities of Consultant's principal place of business
          or the Integra Group, or at such other location as may be agreed to
          by Integra and Consultant.

3.   COMPENSATION AND REIMBURSEMENT.

     3.1  Compensation Rate. Integra agrees to pay Consultant a retainer of
          $50,000 per three month period. Integra agrees to pay Consultant
          within ten (10) days of the beginning of each fiscal quarter,
          provided, however, that the first such payment shall be made on the
          Closing Date, as defined in the Purchase Agreement.

     3.2  Expense Reimbursement. Integra will reimburse Consultant for all
          reasonable travel (approved by Integra prior to such travel) and
          out-of-pocket expenses incurred on Integra's behalf, e.g., travel
          expenses to meet with Integra associates or to represent Integra at
          business meetings and other miscellaneous documented expenses such
          as fax, telephone and postage. Consultant agrees to submit receipts
          for all possible reimbursements as a condition to such
          reimbursement.

4.   REPRESENTATIONS AND WARRANTIES.

     4.1  Interest in Work Product. Consultant's employer presently has no
          interest, and during the course of Consultant's performance of his
          obligations hereunder to Integra Group, shall not acquire any
          interest, in the results of the work product or other work
          conducted by Consultant for the Integra Group; and

     4.2  No Conflict. Consultant agrees and represents and warrants that
          neither the Consultant's performance of the consulting services for
          the Integra Group in the Field, nor the assignment of any of
          Consultant's rights to Integra, conflicts with, or constitutes a
          breach of or a default under any applicable agreement, contract or
          other instrument to which Consultant is a party or by which
          Consultant is bound.


                                      3


<PAGE>

5.   ADDITIONAL COVENANTS OF CONSULTANT.

     5.1  Confidentiality Covenants. Consultant acknowledges and agrees that
          in the course of, or incident to, Consultant's consulting
          relationship with the Integra Group, one or more members of the
          Integra Group may provide to Consultant, or Consultant may
          otherwise become exposed to, Confidential Information. Consultant
          acknowledges that obtaining the Confidential Information is
          intended, and is necessary, to enable Consultant to perform
          Consultant's duties or other functions for the Integra Group as
          provided herein. Consultant recognizes and agrees that the
          confidentiality of the Confidential Information is necessary to the
          ability of the Integra Group to compete effectively with its
          competitors. Consultant recognizes and acknowledges that, in many
          instances, Integra and/or its Affiliates are bound by contractual
          or other obligations to hold and use confidential information
          received from third parties in confidence, and that Consultant's
          failure to do so may constitute a breach of such obligations.
          Consultant therefore acknowledges and agrees that Consultant's
          undertakings herein with respect to the use and dissemination of
          such third party Confidential Information are made and intended for
          the benefit not only of the Integra Group but also of all parties
          that provide the Integra Group with Confidential Information. In
          light of the foregoing, Consultant agrees that:

          5.1.1 Confidentiality and Non-Use. During the term of Consultant's
                consulting relationship with the Integra Group and at all
                times thereafter, except as required in the performance of
                Consultant's duties or other functions for the Integra Group,
                Consultant will not disclose such Confidential Information to
                any third party. Consultant will not use such Confidential
                Information to compete with or adversely affect the business
                or operations of Integra or its Affiliates or those doing
                business with them. Consultant will not use the name of any
                member of the Integra Group, or the name of any member of the
                Integra Group's staff, in connection with any publicity,
                without the prior written approval of Integra.


          5.1.2 Required Disclosure. If Consultant is required by law to
                disclose any Confidential Information, it will, sufficiently
                in advance in order to permit Integra to take steps to prevent
                such disclosure, notify Integra and prior to any disclosure
                shall consult with and assist Integra in obtaining a
                protective order or other appropriate remedy. In any event,
                Consultant will disclose only that portion of the Confidential
                Information which is legally required and will use best
                efforts to assure that confidential treatment is accorded any
                Confidential Information so disclosed.

          5.1.3 Return of Confidential Information. Upon request by Integra
                at any time, Consultant will promptly return to Integra the
                original and all copies of all



                                      4

<PAGE>

                non-oral Confidential Information and will, upon request,
                certify in writing to Integra as to its compliance with this
                paragraph.

          5.1.4 No Grant of Rights. Nothing in this Agreement shall be
                construed to grant Consultant any right or license under any
                patent or trade secret owned, used or licensed by Integra or
                its Affiliates.

     5.2  No Participation of Others. Consultant agrees not to allow any
          person to assist or participate in the consulting work performed
          hereunder unless and until such person has executed an agreement
          with Integra, satisfactory in form and substance to Integra,
          concerning confidentiality and intellectual property and patent
          rights.

     5.3  Covenant Not to Compete. Except as permitted in Section 10.9 of the
          Purchase Agreement, Consultant agrees that, unless acting with the
          prior written consent of Integra, which consent may be granted or
          denied in the sole discretion of Integra, neither Consultant nor
          any of his Affiliates will, directly or indirectly, for a period of
          three (3) years after the Closing Date (as defined in the Purchase
          Agreement) anywhere in the United States or in any other country,
          directly or indirectly:

          (a)  (i) own, manage, operate, control, consult with, participate
               in, or be connected in any manner with the ownership,
               management, operation, or control of any business which
               engages, directly or indirectly, in the marketing, sale or
               distribution of any of the following (collectively, the
               "Protected Products"): (A) any medical device for treating
               central nervous system (i.e., brain and spine) pathologies
               that is used in hospital intensive care units, neuro-intensive
               care units or emergency rooms; or (B) any products used for
               cranial access, management of intracranial hypertension,
               drainage of cerebrospinal fluid and any products related
               thereto, including, without limitation, catheters, sensors and
               drainage systems; (ii) be or become a stockholder, partner,
               owner, agent of, or a consultant to or give financial or other
               assistance to, any person or entity considering engaging in
               any such activities or so engaged; (iii) seek in competition
               with the business of Purchaser or any affiliate of Purchaser
               to procure orders for Protected Products from or do business
               with any customer of Purchaser or any affiliate of Purchaser
               with respect to Protected Products; (iv) solicit, or contact
               with a view to the engagement or employment by, any
               Transferred Employee (as defined in the Purchase Agreement) or
               other person or entity who is an employee or contractor of
               Purchaser or any affiliate of Purchaser; (v) seek to contract
               with or engage (in such a way as to adversely affect or
               interfere with the business of Purchaser or any affiliate of
               Purchaser) any person or entity who has been contracted with
               or engaged to manufacture, assemble, supply or deliver
               Protected Products; or (vi) engage in or participate in any
               effort or act to induce any of the customers, associates,
               consultants,


                                      5

<PAGE>

               or employees of Purchaser or any affiliate of Purchaser
               (including without limitation any Transferred Employee) to
               take any action which is disadvantageous to Purchaser or any
               affiliate of Purchaser; and

          (b)  contact, induce, solicit or influence any client of the
               Business (as defined in the Purchase Agreement) or of
               Purchaser or any affiliate of Purchaser to cause such client
               to terminate or reduce in any material way its relationship
               with the Business and/or Purchaser or any affiliate of
               Purchaser.

               In the event that the provisions of this Section 5.3 should
               ever be deemed to exceed the time or geographic limitations or
               any other limitations permitted by applicable law in any
               jurisdiction, then such provisions shall be deemed reformed in
               such jurisdiction to the maximum permitted by applicable law.
               Consultant specifically acknowledges and agrees that the
               foregoing restrictions are reasonable and necessary to protect
               the legitimate interests of Integra, that Integra would not
               have entered into this Agreement in the absence of such
               restrictions, that any violation of such restrictions will
               result in irreparable injury to Integra, that the remedy at
               law for any breach of the foregoing restrictions will be
               inadequate, and that, in the event of any such breach,
               Integra, in addition to any other relief available to it,
               shall be entitled to temporary injunctive relief before trial
               from any court of competent jurisdiction as a matter of course
               and to permanent injunctive relief without the necessity of
               quantifying actual damages.

6.   TERM AND TERMINATION; SURVIVAL.

     6.1  Initial Term. Unless sooner terminated as provided in this Section,
          this Agreement shall terminate one year after the Effective Date.

     6.2  Early Termination. Integra may terminate this Agreement at any time
          prior to the end of the initial term set forth in Section 6.1 if
          Consultant breaches any of the material terms of this Agreement and
          has not cured such breach to the reasonable satisfaction of Integra
          within two (2) weeks after receiving written notice thereof from
          Integra. Integra will remain obligated for all payments accrued
          prior to the effective termination or expiration of this Agreement.

     6.3  Survival. Anything in this Agreement to the contrary
          notwithstanding, Consultant's obligations under Sections 4, 5 and 7
          shall survive termination of this Agreement for any reason.


                                      6

<PAGE>

7.   MISCELLANEOUS PROVISIONS.

     7.1  Notices. All notices, demands or other communications required or
          permitted to be given pursuant to this Agreement shall be effective
          only if given in writing the delivery of which is verified:

                To Integra:           Integra LifeSciences Corporation
                                      311-C Enterprise Drive
                                      Plainsboro, New Jersey 08536
                                      Attention: Law Department
                                      Phone: (609) 275-0500
                                      Fax: (609) 275-1082

                To Consultant:        George J. Connell
                                      425 Lionville Road
                                      Downingtown, Pennsylvania 19335

          or to such other person, address or fax number as either party may
          hereafter designate to the other by notice given in accordance with
          this Section 7.1.

     7.2  Remedies and Equitable Relief. No remedy herein conferred is
          intended to be exclusive of any other remedy, and each and every
          such remedy shall be cumulative and shall be in addition to every
          other remedy given hereunder or now or hereafter existing at law or
          in equity or by statute or otherwise. Consultant acknowledges that
          damages alone will not be an adequate remedy for any breach or
          violation of its obligations hereunder and that, in addition to any
          other remedies to which Integra may be entitled hereunder or
          otherwise, Integra shall be entitled to injunctive relief,
          including specific performance, with respect to such obligations in
          any court of competent jurisdiction.

     7.3  Waiver. No waiver by any party hereto or any failure by any other
          party hereto to keep or perform any covenant or condition of this
          Agreement shall be deemed to be a waiver of any preceding or
          succeeding breach of the same or other covenant or condition. No
          failure to enforce any provision hereof shall operate as a waiver
          thereof or be deemed to be a release of any rights granted
          hereunder.

     7.4  Severability. If any provision of this Agreement would be held or
          made invalid or unenforceable by a court decision, statute, rule or
          otherwise, such provision shall be construed in such a way as to
          make it valid and enforceable to the maximum extent possible. The
          invalidity or unenforceability of any provision of this Agreement
          shall not affect the remaining provisions of this Agreement, which
          shall be enforceable to the maximum extent permitted by law.

     7.5  Independent Contractors. For purposes of this Agreement and in
          connection with any activity hereunder, Consultant and any person
          associated with Consultant



                                      7
<PAGE>

          shall at all times be independent contractors and not agents or
          employees of Integra.

     7.6  Third Party Beneficiaries. Consultant acknowledges and agrees that
          the Affiliates of Integra are intended third party beneficiaries of
          this Agreement and all rights and benefits granted to Integra
          hereunder are intended to and shall run in favor of all such
          Affiliates, including any person hereinafter acquired by or which
          acquires Integra, or any of its Affiliates, by merger, sale or
          exchange of stock, consolidation, purchase of assets or otherwise.

     7.7  Assignment and Binding Effect. This Agreement is personal and
          Consultant may not assign, transfer (including transfers by
          operation of law) or otherwise dispose of all or any portion of its
          rights under this Agreement without the prior written consent of
          Integra, and any such purported assignment will be void. Integra
          may assign this Agreement to any entity or person without
          Consultant's consent. This Agreement shall be binding on the
          respective successors and permitted assigns of the parties hereto.

     7.8  Governing Law and Jurisdiction. This Agreement shall be construed,
          interpreted and enforced in accordance with, and governed by, the
          laws of the Commonwealth of Pennsylvania, regardless of the effect
          of choice of law principles of such laws.

     7.9  Headings. The headings in this Agreement are for convenience of
          reference only and in no way define or limit any of the provisions
          hereof or otherwise affect their construction or effect.

     7.10 Counterparts. This Agreement may be executed in multiple
          counterparts, each of which shall be deemed an original, but all of
          which shall constitute one and the same instrument.

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the
day and year first written above.

CLINICAL NEURO SYSTEMS HOLDINGS LLC         GEORGE J. CONNELL

By:  Integra LifeSciences Corporation,      ---------------------------------
         its sole member

By:
    ----------------------------------
      Stuart M. Essig
      Chief Executive Officer


                                8



<PAGE>


Exhibit 99


Integra LifeSciences Acquires Clinical Neuro Systems; A Leader in Neurosurgical
Drainage and Monitoring Systems

PLAINSBORO, N.J., Jan. 18 /PRNewswire/ -- Integra LifeSciences Holdings
Corporation (Nasdaq: IART) today announced that it has acquired the business,
including certain assets and liabilities, of Clinical Neuro Systems, a leading
manufacturer and marketer of neurosurgical products, for $6.8 million. Clinical
Neuro Systems designs, manufactures and sells neurosurgical external ventricular
drainage systems including catheters and drainage bags, as well as cranial
access kits.

Patients who have suffered a traumatic injury often need drainage of cerebral
spinal fluid and monitoring of intracranial pressure. Treatment is delivered
within neuro intensive care units, general surgical intensive care units, and
emergency rooms.

The Clinical Neuro Systems acquisition expands the neurotrauma position of
Integra's neurosurgical division, Integra NeuroCare. Integra NeuroCare is
already a recognized leader through its Camino(R) and Ventrix(R) products for
fiber optic-based monitoring of intracranial pressure. The combination of Camino
and Clinical Neuro Systems will enable Integra NeuroCare to offer a wider range
of products to the neurotrauma medical team. This broader product offering will
complement Integra NeuroCare's continuing emphasis on clinical educational
programs in the neurotrauma unit.

Revenues of the acquired Clinical Neuro Systems business were approximately $3.2
million for the four quarters ended December 31, 1999.

In addition to the portfolio of new products, the acquisition permits Integra
NeuroCare to expand its direct sales force in the United States. Together with
Integra NeuroCare's seven-person medical education unit, Integra NeuroCare's
direct selling effort will expand to 40 U.S. field personnel focused on
neurotrauma and neurosurgery. Integra NeuroCare's network of approximately 60
international distributors enables the Company to sell its products in over 70
countries worldwide.

The $6.8 million acquisition price was comprised of $4 million of cash and a
secured promissory note to the seller in the amount of $2.8 million, payable in
two equal installments in January 2001 and January 2002.

"This acquisition clearly establishes Integra NeuroCare as an industry leader in
the treatment of neurotrauma," said Stuart M. Essig, President and Chief
Executive Officer of Integra LifeSciences. "It broadens and strengthens Integra
with established products and a well-trained and experienced sales group. We are
now positioned to accelerate the pace of our acquisition and partnership program
in 2000. Each new acquisition strengthens our strategic plan for becoming a
global leader in neurosurgery."

Clinical Neuro System's operations include a facility in Exton, Pennsylvania
that manufactures, packages and distributes the Clinical Neuro Systems catheter
and drainage products. This manufacturing facility also allows for efficient
customized assemblies of cranial access kits.


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Integra LifeSciences Holdings Corporation has its corporate headquarters in
Plainsboro, New Jersey and facilities located in San Diego, California, Anasco,
Puerto Rico and Exton, Pennsylvania. The Company has approximately 425
employees. Please feel free to visit the Company's Website at
(http://www.integra-LS.com).

Certain statements made in this press release related to the Company's products
and development efforts, as well as their therapeutic applications and outcomes,
are forward-looking, are subject to technological, regulatory, competitive and
economic uncertainty (as well as the other risks detailed in the Company's
filings with the Securities and Exchange Commission), and are made pursuant to
the safe harbor provisions of the Securities Litigation Reform Act of 1995.

SOURCE Integra LifeSciences Holdings Corporation

CONTACT: John B. Henneman, III of Integra LifeSciences Holdings Corporation,
                     609-936-2481, [email protected]/




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