GUILFORD PHARMACEUTICALS INC
SC 13D, 1997-10-14
PHARMACEUTICAL PREPARATIONS
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                UNITED STATES SECURITIES AND EXCHANGE COMMISSION

                             Washington, D.C. 20549



                                  SCHEDULE 13D


                    Under the Securities Exchange Act of 1934
                               (Amendment No. 1 )

                          Guilford Pharmaceuticals Inc.
                                (Name of Issuer)


                                  Common Stock
                         (Title of Class of Securities)


                                    401829106
                                 (CUSIP Number)


                                 Thomas C. Seoh
                  Vice President, General Counsel and Secretary
                              6611 Tributary Street
- --------------------------------------------------------------------------------
                            Baltimore, Maryland 21224
- --------------------------------------------------------------------------------
            (Name, Address and Telephone Number of Person Authorized
                     to Receive Notices and Communications)


                               September 22, 1997
- --------------------------------------------------------------------------------
             (Date of Event which Requires Filing of this Statement)


If the filing person has previously  filed a statement on Schedule 13G to report
the  acquisition  which is the subject of this  Schedule 13D, and is filing this
schedule because of Rule 13d-1(b)(3) or (4), check the following box: |_|

- --------------------------------------------------------------------------------
     Check the following box if a fee is being paid with this statement: |_|

- --------------------------------------------------------------------------------
                               Page 1 of 11 Pages


<PAGE>

- -------------------------                          -----------------------------
CUSIP No.  401829106              Schedule 13D          Page 2 of 11 Pages     
- --------------------------                         -----------------------------



- --------------------------------------------------------------------------------
  1      NAME OF REPORTING PERSON:            The Abell Foundation, Inc.


         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON    52-6036106
- -------- -----------------------------------------------------------------------
  2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                               (a) |_|
                                                               (b) |_|
- -------- -----------------------------------------------------------------------
  3      SEC USE ONLY

- -------- -----------------------------------------------------------------------
  4      SOURCE OF FUNDS*
         WC
- -------- -----------------------------------------------------------------------
  5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) or 2(e)                                        |_|
- -------- -----------------------------------------------------------------------
  6      CITIZENSHIP OR PLACE OF ORGANIZATION

         Maryland
- -------- -----------------------------------------------------------------------
                       7    SOLE VOTING POWER

                                     750,000
                      ----- ----------------------------------------------------
       NUMBER          8    SHARED VOTING POWER
     OF SHARES
    BENEFICIALLY
      OWNED BY        ----- ----------------------------------------------------
        EACH           9    SOLE DISPOSITIVE POWER
     REPORTING
    PERSON WITH                      750,000
                      ----- ----------------------------------------------------
                       10   SHARED DISPOSITIVE POWER


- -------- -----------------------------------------------------------------------
  11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                                    750,000
- -------- -----------------------------------------------------------------------
  12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

- -------- -----------------------------------------------------------------------
  13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                                    4.02%
- -------- -----------------------------------------------------------------------
  14     TYPE OF REPORTING PERSON*

                                    CO
- -------- -----------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>


- -------------------------                          -----------------------------
CUSIP No.  401829106              Schedule 13D          Page 3 of 11 Pages
- --------------------------                         -----------------------------

- -------- -----------------------------------------------------------------------
  1      NAME OF REPORTING PERSON:                   W. Shepherdson Abell


         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON       ###-##-####
- -------- -----------------------------------------------------------------------
  2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                (a)  |_|
                                                                (b)  |_|
- -------- -----------------------------------------------------------------------
  3      SEC USE ONLY
         
- -------- -----------------------------------------------------------------------
  4      SOURCE OF FUNDS*

         N/A This  individual is a Reporting  Person solely because he is one of
         the three individuals  responsible for securities  investment decisions
         made by The Abell Foundation, Inc.
- -------- -----------------------------------------------------------------------
  5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) or 2(e)                                        |_|

- -------- -----------------------------------------------------------------------
  6      CITIZENSHIP OR PLACE OF ORGANIZATION

         USA
- -------- -----------------------------------------------------------------------
                       7    SOLE VOTING POWER

                                750,000 (1)(2)        2,125 T/E with wife (3)
                      ----- ----------------------------------------------------
       NUMBER          8    SHARED VOTING POWER
     OF SHARES
    BENEFICIALLY
      OWNED BY        ----- ----------------------------------------------------
        EACH           9    SOLE DISPOSITIVE POWER
     REPORTING
    PERSON WITH                 750,000 (1)(2)        2,125 T/E with wife (3)
                      ----- ----------------------------------------------------
                       10   SHARED DISPOSITIVE POWER


- -------- -----------------------------------------------------------------------
  11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                               750,000 (1)(2)         2,125 T/E with wife (3)
- -------- -----------------------------------------------------------------------
  12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

- -------- -----------------------------------------------------------------------
  13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                              4.02% (1)(2)          0.01% (3) 
- -------- -----------------------------------------------------------------------
  14     TYPE OF REPORTING PERSON*

                                    IN
- -------- -----------------------------------------------------------------------

                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>
- -------------------------                          -----------------------------
CUSIP No.  401829106              Schedule 13D          Page 4 of 11 Pages 
- ---------------------                         -----------------------------


- -------- -----------------------------------------------------------------------
  1      NAME OF REPORTING PERSON:              George L. Bunting, Jr.


         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
- -------- -----------------------------------------------------------------------
  2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                            (a) |_|
                                                            (b) |_|
- -------- -----------------------------------------------------------------------
  3      SEC USE ONLY

- -------- -----------------------------------------------------------------------
  4      SOURCE OF FUNDS*

         N/A This  individual is a Reporting  Person solely because he is one of
         the three individuals  responsible for securities  investment decisions
         made by The Abell Foundation, Inc.
- -------- -----------------------------------------------------------------------
  5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) or 2(e)                                        |_|

- -------- -----------------------------------------------------------------------
  6      CITIZENSHIP OR PLACE OF ORGANIZATION

         USA
- -------- -----------------------------------------------------------------------
                       7    SOLE VOTING POWER

                                750,000 (1)(2)            1,650 (3)
                      ----- ----------------------------------------------------
       NUMBER          8    SHARED VOTING POWER
     OF SHARES
    BENEFICIALLY                a 1% interest in an investment
      OWNED BY                  that owns 3,500 Shares
                     ----- ----------------------------------------------------
        EACH           9    SOLE DISPOSITIVE POWER
     REPORTING
    PERSON WITH                 750,000 (1)(2)            1,650 (3)
                      ----- ----------------------------------------------------
                       10   SHARED DISPOSITIVE POWER

                               a 1% interest in an investment
                               that owns 3,500 Shares
- -------- -----------------------------------------------------------------------
  11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                               750,000 (1)(2)             1,650 (3)
- -------- -----------------------------------------------------------------------
  12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

- -------- -----------------------------------------------------------------------
  13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                               4.02% (1)(2)            0.01% (3)
- -------- -----------------------------------------------------------------------
  14     TYPE OF REPORTING PERSON*

                                    IN
- -------- -----------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!

<PAGE>

- -------------------------                          -----------------------------
CUSIP No.  401829106              Schedule 13D          Page 5 of 11 Pages
- --------------------------                         -----------------------------


- -------- -----------------------------------------------------------------------
  1      NAME OF REPORTING PERSON:                       Robert Garrett


         S.S. or I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
- -------- -----------------------------------------------------------------------
  2      CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                              (a) |_|
                                                              (b) |_|
- -------- -----------------------------------------------------------------------
  3      SEC USE ONLY

- -------- -----------------------------------------------------------------------
  4      SOURCE OF FUNDS*

         N/A This  individual is a Reporting  Person solely because he is one of
         the three individuals  responsible for securities  investment decisions
         made by The Abell Foundation, Inc.
- -------- -----------------------------------------------------------------------
  5      CHECK BOX IF DISCLOSURE OF LEGAL PROCEEDINGS IS REQUIRED PURSUANT TO
         ITEMS 2(d) or 2(e)                                        |_|

- -------- -----------------------------------------------------------------------
  6      CITIZENSHIP OR PLACE OF ORGANIZATION

         USA
- --------------------- ----- ----------------------------------------------------
                       7    SOLE VOTING POWER

                              750,000 (1)(2)                None (3)
                      ----- ----------------------------------------------------
       NUMBER          8    SHARED VOTING POWER
     OF SHARES
    BENEFICIALLY
      OWNED BY
                      ----- ----------------------------------------------------
        EACH           9    SOLE DISPOSITIVE POWER
     REPORTING
    PERSON WITH               750,000 (1)(2)                None (3)
                      ----- ----------------------------------------------------
                       10   SHARED DISPOSITIVE POWER


- -------- -----------------------------------------------------------------------
  11     AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

                              750,000 (1)(2)               None (3)
- -------- -----------------------------------------------------------------------
  12     CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (11) EXCLUDES CERTAIN SHARES*

- -------- -----------------------------------------------------------------------
  13     PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 11

                              4.02% (1)(2)
- -------- -----------------------------------------------------------------------
  14     TYPE OF REPORTING PERSON*

                              IN
- -------- -----------------------------------------------------------------------
                      *SEE INSTRUCTIONS BEFORE FILLING OUT!


<PAGE>

- -------------------------                          -----------------------------
CUSIP No.  401829106              Schedule 13D          Page 6 of 11 Pages      
- --------------------------                         -----------------------------

Item 1.  Security and Issuer

     (a)  Name of Issuer: Guilford Pharmaceuticals Inc.

     (b)  Address of Issuer's Principal Executive Offices 6611 Tributary Street,
          Baltimore, Maryland

     (c) Title and Class of Security: Common Stock, par value $.01 per share

Item 2.  Identity and Background

     The Abell Foundation, Inc. provides the following information:

     (a)  Name of Person Filing: The Abell Foundation, Inc.

     (b)  Citizenship/State of Incorporation: Maryland

     (c)  Principal   Business:    Making   grants   to   qualified   charitable
          organizations

     (d)  Address of Principal Business Office or, if none, Residence

          111  South Calvert Street, Baltimore, Maryland 21202

     (e)  The Abell Foundation, Inc. (the "Foundation") has not, during the last
          five years,  (i) been  convicted in a criminal  proceeding  (excluding
          traffic violations and similar  misdemeanors) nor (ii) been subject to
          a judgment, decree or final order of a judicial or administrative body
          of  competent   jurisdiction   enjoining  future   violations  of,  or
          prohibiting  or  mandating  activities  subject  to,  federal or state
          securities laws or finding any violation with respect to such laws.

     W.  Shepherdson  Abell is  filing as a trustee  and  member of the  Finance
Committee  of the  Foundation  and  provides the  following  information  solely
because of those relationships:

     (a)  Name of Person Filing: W. Shepherdson Abell

     (b)  Address of Principal Business Office or, if none, Residence

          8401 Connecticut Avenue, Chevy Chase, Maryland 20815

     (c)  Present principal occupation and name and address of employer:

          Attorney, Partner of Furey,  Doolan & Abell, 8401 Connecticut  Avenue,
          Chevy Chase, Maryland 20815.

    (d(e) W.  Shepherdson  Abell has   not, during the last five years, (i) been
          convicted in a criminal  proceeding  (excluding traffic violations and
          similar  misdemeanors) nor (ii) been subject to a judgment,  decree or
          final  order  of  a  judicial  or  administrative  body  of  competent
          jurisdiction   enjoining  future  violations  of,  or  prohibiting  or
          mandating  activities  subject to, federal or state securities laws or
          finding any violation with respect to such laws.

     (f)  Citizenship: United States

<PAGE>

- -------------------------                          -----------------------------
CUSIP No.  401829106              Schedule 13D          Page 7 of 11 Pages      
- --------------------------                         -----------------------------


     George L.  Bunting,  Jr. is filing as a trustee  and member of the  Finance
Committee  of the  Foundation  and  provides the  following  information  solely
because of those relationships:

     (a)  Name of Person Filing: George L. Bunting, Jr.

     (b)  Address of Principal Business Office or, if none, Residence

          9690 Deerco Road, Suite 350, Timonium, Maryland 21093

     (c)  Present principal occupation and name and address of employer:

          Managing family  investments,  Bunting  Management  Group, 9690 Deerco
          Road, Suite 350, Timonium, Maryland 21093.

   (d)(e) George L. Bunting, Jr. has not, during the last five years, (i) been
          convicted in a criminal  proceeding  (excluding traffic violations and
          similar  misdemeanors) nor (ii) been subject to a judgment,  decree or
          final  order  of  a  judicial  or  administrative  body  of  competent
          jurisdiction   enjoining  future  violations  of,  or  prohibiting  or
          mandating  activities  subject to, federal or state securities laws or
          finding any violation with respect to such laws.

     (f)  Citizenship: United States

     Robert  Garrett is filing as a trustee and member of the Finance  Committee
of the Foundation and provides the following information solely because of those
relationships:

     (a)  Name of Person Filing: Robert Garrett

     (b)  Address of Principal Business Office or, if none, Residence

          866  Third Avenue, 26th Floor, New York, New York 10022

     (c)  Present principal occupation and name and address of employer:

          Investment  Banker,  President of Admedia  Partners,  Inc.,  866 Third
          Avenue, 26th Floor, New York, New York 10022.

  (d)(e)  Robert  Garrett  has  not,   during  the  last  five  years,(i)  been
          convicted in a criminal  proceeding  (excluding traffic violations and
          similar  misdemeanors) nor (ii) been subject to a judgment,  decree or
          final  order  of  a  judicial  or  administrative  body  of  competent
          jurisdiction   enjoining  future  violations  of,  or  prohibiting  or
          mandating  activities  subject to, federal or state securities laws or
          finding any violation with respect to such laws.

     (f)  Citizenship: United States

<PAGE>


- -------------------------                          -----------------------------
CUSIP No.  401829106              Schedule 13D          Page 8 of 11 Pages   
- --------------------------                         -----------------------------


Item 3.   Source and Amount of Funds or Other Consideration.

     Effective  February 17, 1995, the  Foundation and Guilford  Pharmaceuticals
Inc.  (the  "Issuer")  formed  a  new  corporation,  Gell  Pharmaceuticals  Inc.
("Gell"),  in which the Issuer acquired a 20% equity interest and the Foundation
acquired,  for $2,500,000 in cash, an 80% equity interest.  The cash used by the
Foundation to acquire its interest did not come from borrowing.  On November 12,
1996, the Issuer effected a 3-for-2 split of its Common Stock,  resulting in the
ability  of the  Foundation  to  acquire  an  additional  250,000  shares of the
Issuer's  Common Stock for no additional  consideration.  This  acquisition  was
previously reported on the Foundation's Schedule 13D filed in June 1995.

     On March 22, 1996, the Foundation  purchased 125,000 shares of the Issuer's
Common Stock in an  underwritten  public offering by the Issuer at a price equal
to $20 per share, or an aggregate purchase price of $2,500,000. The cash used by
the  Foundation  to  acquire  its  interest  did not  come  from  borrowing.  In
connection with the Issuer's  November 12, 1996 stock split,  the Foundation was
issued  an  additional  62,500  shares  of  the  Issuer's  Common  Stock  for no
additional consideration.

     On March 5, 1997, the Foundation exercised its right to exchange its equity
interest  in Gell  for  750,000  shares  of the  Issuer's  Common  Stock  for no
additional consideration.


Item 4.  Purpose of Transaction

     The  Foundation  acquired  the  securities  of  Gell as an  investment  and
exchanged its interest in Gell for securities of the Issuer upon a determination
by the  Foundation  that a 500,000  share  interest  in the  Issuer was a better
investment for the Foundation  than an 80% equity  interest in Gell. In order to
protect its initial investment in the Issuer, the Foundation made the additional
acquisition in March 1996.

     Except  as set forth  above,  the  Foundation  does not have as of the date
hereof any plans or proposals which relate to or would result in:

     (a)  the  acquisition by any person of additional  securities of the Issuer
          or the disposition of securities of the Issuer;

     (b)  an   extraordinary   corporate   transaction,   such   as  a   merger,
          reorganization or liquidation of securities of the Issuer;

     (c)  a sale or transfer of a material amount of assets of the Issuer;

     (d)  any change in the present  board of  directors  or  management  of the
          Issuer,  including any plans or proposals to change the number or term
          of  directors  or to fill  any  existing  vacancies  on the  board  of
          directors;  provided,  however,  that  from the  time  the  Foundation
          exchanged  its  interest  in Gell for 750,000  shares of the  Issuer's
          Common Stock and until it sold 145,000  shares in September  1997, the
          Foundation  exercised  the right to appoint one member to the Issuer's
          Board of Directors;

     (e)  any material change in the present  capitalization  or dividend policy
          of the Issuer;

     (f)  any  other  material  change in the  Issuer's  business  or  corporate
          structure;


<PAGE>


- -------------------------                          -----------------------------
CUSIP No.  401829106              Schedule 13D          Page 9 of 11 Pages 
- --------------------------                         -----------------------------

     (g)  any  changes  in  the  Issuer's   charter,   by-laws  or   instruments
          corresponding   thereto  or  other   actions   which  may  impede  the
          acquisition of control of the Issuer by any person;

     (h)  causing a class of  securities  of the  Issuer to be  delisted  from a
          national securities exchange or to cease to be authorized to be quoted
          in  an  inter-dealer   quotation  system  of  a  registered   national
          securities association;

     (i)  causing a class of  securities  of the Issuer to become  eligible  for
          termination  of  registration  pursuant  to  Section  12(g)(4)  of the
          Exchange Act; or

     (j)  any action similar to any of those enumerated above.

     Notwithstanding  anything to the contrary  contained herein, the Foundation
reserves the right to change its present  intentions with respect to the matters
described in this paragraph.

     In  reaching  any  conclusion  as to  its  future  course  of  action,  the
Foundation will take into  consideration  various factors  regarding the Issuer,
such as its business and prospects and general economic conditions and money and
stock market conditions.

Item 5.  Interest in Securities of Issuer

     (a) According to information set forth in the Issuer's Quarterly Report for
the Quarter ended June 30, 1997,  which the Foundation  does not have any reason
to believe is incorrect,  there are 18,641,991 shares of the Common Stock issued
and outstanding.

     (b) As of September 22, 1997, the Foundation beneficially owned and had the
sole power to vote and  dispose of 750,000  shares.  For  purposes of Rule 13d-3
promulgated  under the Exchange Act, the Reporting  Persons1,2  may be deemed to
beneficially  own 4.02% of the shares,  calculated  by dividing  (i) the 750,000
shares by (ii) the 18,641,991 shares outstanding.

     (c) The Foundation  sold 187,500 shares of the Issuer's Common Stock during
the period of September 9, 1997 through September 22, 1997. Each transaction was
made on the open market  through a  broker-dealer;  and,  in each case,  the per
share  sales  price for the  Common  Stock was  between  the price of $30.00 and
$30.37, yielding aggregate gross proceeds to the Foundation of $5,647,936.61.

     (d) The Reporting  Persons ceased to be the  beneficial  owner of more than
five  percent of the Common  Stock of the Issuer on  September 9, 1997 after the
Foundation's sale of 45,000 shares of the Issuer's Common Stock on that date.


<PAGE>


- -------------------------                          -----------------------------
CUSIP No.  401829106              Schedule 13D          Page 10 of 11 Pages 
- --------------------------                         -----------------------------



Item 6. Contracts, Arrangements, Understandings or Relationships with Respect to
Securities of the Issuer

     Other  than  as  described   below,   there  are  presently  no  contracts,
arrangements,  understandings  or  relationships  (legal or otherwise) among the
persons  filing this  Statement,  or between such persons and any other  person,
with respect to any  securities  of the Issuer,  including,  but not limited to,
transfer or voting of any securities,  finder's fees,  joint  ventures,  loan or
option arrangements,  puts or calls, guarantees or profits,  division of profits
or loss, or the giving or withholding of proxies.  The  relationships  mentioned
above are as follows:

          (i)  Messrs.  Abell,  Bunting and Garrett are trustees and the members
               of  the  Finance  Committee  of  the  Board  of  Trustees  of the
               Foundation.

         (ii)  As disclosed  herein,  certain of the reporting  persons directly
               beneficially own shares of the Issuer.

        (iii)  Mr.  Bunting is a director of the Issuer and sits on its Board of
               Directors.

Item 7. Material to be filed as Exhibits

     None.











Notes to Schedule 13D
- ---------------------

1    Each of Messrs.  Abell,  Bunting and Garrett disclaims beneficial ownership
     of these securities,  and this report shall not be deemed an admission that
     the reporting  person is the  beneficial  owner of such  securities for any
     purpose.

2    These  shares  represent  the same  shares  previously  listed by The Abell
     Foundation, Inc. and are not cumulative.

3    These shares are beneficially owned by the reporting person directly.


<PAGE>


- -------------------------                          -----------------------------
CUSIP No.  401829106              Schedule 13D          Page 11 of 11 Pages
- --------------------------                         -----------------------------



                                    SIGNATURE

     After  reasonable  inquiry and to the best of my  knowledge  and belief,  I
certify that the information  set forth in this Statement is true,  complete and
correct.

     The parties agree that this statement is filed on behalf of each of them.

Dated:  October 10, 1997

                                       THE ABELL FOUNDATION, INC.


                                        By: /s/   Robert C. Embry, Jr.
                                           ---------------------------
                                           Name:  Robert C. Embry, Jr.
                                           Title: President


                                                                
                                        /s/ W. Shepherdson Abell
                                        ------------------------
                                        W. Shepherdson Abell



                                       /s/  George L. Bunting, Jr.
                                       ----------------------------
                                       George L. Bunting, Jr.
 


                                       /s/  Robert Garrett
                                       ----------------------------
                                       Robert Garrett




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